japanese encephalitis virus

Summary

Summary: A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent.

Top Publications

  1. Huang J, Lin H, Wang Y, Weng M, Ji D, Kuo M, et al. Sensitive and specific detection of strains of Japanese encephalitis virus using a one-step TaqMan RT-PCR technique. J Med Virol. 2004;74:589-96 pubmed
    A rapid, sensitive, and accurate laboratory diagnostic test is needed for distinguishing Japanese encephalitis virus (JEV) from other diseases featuring similar clinical symptoms and also for preventing potential outbreaks...
  2. Xie R, Xu F, Zhu H, Cheng Y, Fu G, Yao P, et al. [Development and evaluation of TaqMan-based one-step reverse transcription-polymerase chain reaction assay for the detection of Japanese encephalitis virus]. Zhonghua Liu Xing Bing Xue Za Zhi. 2009;30:277-80 pubmed
    ..based real-time reverse transcription-polymerase chain reaction (RT-PCR) assay for the detection of Japanese encephalitis virus. The gene sequences of Japanese encephalitis virus downloaded from the GenBank was aligned, using the ..
  3. De Groot A, Martin W, Moise L, Guirakhoo F, Monath T. Analysis of ChimeriVax Japanese Encephalitis Virus envelope for T-cell epitopes and comparison to circulating strain sequences. Vaccine. 2007;25:8077-84 pubmed
    ..with viral immune escape and may influence the outcome of vaccination against the highly variable Japanese Encephalitis Virus (JEV)...
  4. Qi W, Hua R, Yan L, Tong G, Zhang G, Ren T, et al. Effective inhibition of Japanese encephalitis virus replication by small interfering RNAs targeting the NS5 gene. Virus Res. 2008;132:145-51 pubmed publisher
    b>Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, causes an acute infection of the central nervous system resulting in encephalitis of humans and many kinds of animals...
  5. Schuh A, Li L, Tesh R, Innis B, Barrett A. Genetic characterization of early isolates of Japanese encephalitis virus: genotype II has been circulating since at least 1951. J Gen Virol. 2010;91:95-102 pubmed publisher
    b>Japanese encephalitis virus (JEV) consists of five genotypes (GI-V)...
  6. Santhosh S, Parida M, Dash P, Pateriya A, Pattnaik B, Pradhan H, et al. Development and evaluation of SYBR Green I-based one-step real-time RT-PCR assay for detection and quantitation of Japanese encephalitis virus. J Virol Methods. 2007;143:73-80 pubmed
    One-step SYBR Green I-based real-time RT-PCR assay for rapid detection as well as quantitation of Japanese encephalitis virus (JEV) in acute-phase patient CSF samples by targeting the NS3 gene was developed...
  7. Roy A, Tandon R, Agarwal S, Banerjee G. Seroprevalence of Japanese encephalitis virus infection in Lucknow, Uttar Pradesh. Indian J Med Res. 2006;124:211-2 pubmed
  8. Satchidanandam V, Uchil P, Kumar P. Organization of flaviviral replicase proteins in virus-induced membranes: a role for NS1' in Japanese encephalitis virus RNA synthesis. Novartis Found Symp. 2006;277:136-45; discussion 145-8, 251-3 pubmed
    ..Exogenous addition of recombinant NS1' to TX100 treated JEV-induced membranes restored the defect in the release step of RNA synthesis. Our results suggest for the first time a direct role for JEV NS1' in viral RNA synthesis in vitro. ..
  9. Kitai Y, Shoda M, Kondo T, Konishi E. Epitope-blocking enzyme-linked immunosorbent assay to differentiate west nile virus from Japanese encephalitis virus infections in equine sera. Clin Vaccine Immunol. 2007;14:1024-31 pubmed
    West Nile virus (WNV) is now widely distributed worldwide, except in most areas of Asia where Japanese encephalitis virus (JEV) is distributed...

More Information

Publications177 found, 100 shown here

  1. Appaiahgari M, Abdin M, Bansal K, Vrati S. Expression of Japanese encephalitis virus envelope protein in transgenic tobacco plants. J Virol Methods. 2009;162:22-9 pubmed publisher
    The virus envelope (E) protein of Japanese encephalitis virus induces virus-neutralizing antibodies and is therefore a potential vaccine antigen...
  2. Konishi E, Kitai Y, Tabei Y, Nishimura K, Harada S. Natural Japanese encephalitis virus infection among humans in west and east Japan shows the need to continue a vaccination program. Vaccine. 2010;28:2664-70 pubmed publisher
    ..6% in both survey areas. Thus, JE virus remains present and active in nature in Japan. Therefore, continuing a vaccination program is indispensable to prevent JE infection in humans...
  3. Lian W, Liau M, Mao C. Diagnosis and genetic analysis of Japanese encephalitis virus infected in horses. J Vet Med B Infect Dis Vet Public Health. 2002;49:361-5 pubmed
    ..2-5.7% and at the amino acid level of 0-4.3% were conserved with other JE strains. The results demonstrated that the pathogens causing equine encephalitis were JE viruses. The strains were closely related to Taiwanese isolates. ..
  4. Erlanger T, Weiss S, Keiser J, Utzinger J, Wiedenmayer K. Past, present, and future of Japanese encephalitis. Emerg Infect Dis. 2009;15:1-7 pubmed publisher
    ..On a global scale, however, the incidence of JE may decline as a result of large-scale vaccination programs implemented in China and India. ..
  5. Das S, Ghosh D, Basu A. Japanese encephalitis virus induce immuno-competency in neural stem/progenitor cells. PLoS ONE. 2009;4:e8134 pubmed publisher
    ..We utilized both in vivo mouse model and in vitro neurosphere model of Japanese encephalitis virus (JEV) infection for the study...
  6. Liao S, Raung S, Chen C. Japanese encephalitis virus stimulates superoxide dismutase activity in rat glial cultures. Neurosci Lett. 2002;324:133-6 pubmed
    b>Japanese encephalitis virus (JEV) infection is commonly associated with inflammatory reaction and neurological disease that occurs in the infected animals...
  7. Chen C, Chen J, Chen S, Liao S, Raung S. Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection. J Virol. 2004;78:12107-19 pubmed
    Infection with Japanese encephalitis virus (JEV) causes cerebral inflammation and stimulates inflammatory cytokine expression...
  8. Lobigs M, Pavy M, Hall R. Cross-protective and infection-enhancing immunity in mice vaccinated against flaviviruses belonging to the Japanese encephalitis virus serocomplex. Vaccine. 2003;21:1572-9 pubmed
    The Japanese encephalitis virus serocomplex is a group of mosquito-borne flaviviruses that cause severe encephalitic disease in humans...
  9. Raung S, Chen S, Liao S, Chen J, Chen C. Japanese encephalitis virus infection stimulates Src tyrosine kinase in neuron/glia. Neurosci Lett. 2007;419:263-8 pubmed
    b>Japanese encephalitis virus (JEV) is a neurotropic virus. The clinically manifestation of JEV-induced encephalitis is characterized by the brain inflammation and neuronal dysfunction and/or destruction...
  10. Tsai K, Huang C, Wu W, Chuang C, Lin C, Chen W. Parallel infection of Japanese encephalitis virus and Wolbachia within cells of mosquito salivary glands. J Med Entomol. 2006;43:752-6 pubmed
    ..mosquito Armigeres subalbatus Coquillett, colocalization of Wolbachia and inoculated Japanese encephalitis virus (family Flaviviridae, genus Flavivirus, JEV) in salivary gland (SG) cells was shown by electron ..
  11. Gupta A, Lad V, Koshy A. Early death of Japanese encephalitis virus-infected mice administered a neutralizing cross-reactive monoclonal antibody against glycoprotein E. Acta Virol. 2009;53:191-5 pubmed
    ..auto-reactive (NHA-1 and NHA-2) monoclonal antibodies (MAbs) against glycoprotein E (gpE) of Japanese encephalitis virus (JEV) administered 1 day before or 2 days after intracerebral (i.c...
  12. Mori Y, Yamashita T, Tanaka Y, Tsuda Y, Abe T, Moriishi K, et al. Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells. J Virol. 2007;81:8477-87 pubmed
    ..In this study, we found a small capsid protein in cells infected with Japanese encephalitis virus (JEV) but not in the viral particles...
  13. Bharati K, Appaiahgari M, Vrati S. Effect of cytokine-encoding plasmid delivery on immune response to Japanese encephalitis virus DNA vaccine in mice. Microbiol Immunol. 2005;49:349-53 pubmed
    We have previously shown that immunization of mice with plasmid pMEa synthesizing Japanese encephalitis virus (JEV) envelope protein induced anti-JEV humoral and cellular immune responses...
  14. Yu F, Hasebe F, Inoue S, Mathenge E, Morita K. Identification and characterization of RNA-dependent RNA polymerase activity in recombinant Japanese encephalitis virus NS5 protein. Arch Virol. 2007;152:1859-69 pubmed
    The complete nonstructural NS5 gene of Japanese encephalitis virus (JEV) was amplified and cloned into an expression vector. The NS5 protein was expressed in Escherichia coli and purified by His-tag based affinity chromatography...
  15. Ge F, Qiu Y, Yang Y, Chen P. An hsp70 fusion protein vaccine potentiates the immune response against Japanese encephalitis virus. Arch Virol. 2007;152:125-35 pubmed
    To evaluate the possibility of developing an effective subunit vaccine against Japanese encephalitis virus (JEV), mice were intraperitoneally immunized with either a neutralizing epitope (a 27-amino-acid region of the JEV E protein), or ..
  16. Lin C, Wu C, Hsiao N, Chang C, Li S, Wan L, et al. Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71. Int J Antimicrob Agents. 2008;32:355-9 pubmed publisher
    ..The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in ..
  17. Zhang F, Ma W, Zhang L, Aasa Chapman M, Zhang H. Expression of particulate-form of Japanese encephalitis virus envelope protein in a stably transfected Drosophila cell line. Virol J. 2007;4:17 pubmed
    b>Japanese encephalitis virus (JEV), a member of the family Flaviviridae, is an important mosquito-borne human pathogen. Its envelope glycoprotein (E) is the major determinant of the pathogenicity and host immune responses...
  18. Yang D, Kim B, Kweon C, Kwon J, Lim S, Han H. Molecular characterization of full-length genome of Japanese encephalitis virus (KV1899) isolated from pigs in Korea. J Vet Sci. 2004;5:197-205 pubmed
    We have determined the complete nucleotide and deduced amino acid sequences of the Japanese encephalitis virus (JEV) strain KV1899, isolated from a fattening pig in Korea...
  19. Konishi E, Shoda M, Kondo T. Analysis of yearly changes in levels of antibodies to Japanese encephalitis virus nonstructural 1 protein in racehorses in central Japan shows high levels of natural virus activity still exist. Vaccine. 2006;24:516-24 pubmed
    ..2-26.7% in Ibaraki and 0-41.7% in Shiga, indicating that high levels of JE virus activity still existed in central Japan. ..
  20. Yang D, Kim B, Lim S, Kwon J, Lee K, Choi C, et al. Development and evaluation of indirect ELISA for the detection of antibodies against Japanese encephalitis virus in swine. J Vet Sci. 2006;7:271-5 pubmed
    The Japanese encephalitis virus (JEV) is one of causative agents of reproductive failure in pregnant sows...
  21. Chiou C, Hu C, Chen P, Liao C, Lin Y, Wang J. Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein. J Gen Virol. 2003;84:2795-805 pubmed
    Previously reported findings by our group showed that non-structural protein 3 (NS3) of Japanese encephalitis virus (JEV) was localized mainly in the JEV-induced convoluted membrane (CM), which has been proposed to originate from rough ..
  22. Chuang C, Chiou S, Liang L, Chen W. Short report: detection of Japanese encephalitis virus in mouse peripheral blood mononuclear cells using an in situ reverse transcriptase-polymerase chain reaction. Am J Trop Med Hyg. 2003;69:648-51 pubmed
    ..This method is unique in that the reactions can be conducted in tubes; this makes it convenient, accurate, and efficient compared with the conventional in situ RT-PCR on slides...
  23. Wei J, Huang Y, Zhong D, Kang L, Ishag H, Mao X, et al. Design and evaluation of a multi-epitope peptide against Japanese encephalitis virus infection in BALB/c mice. Biochem Biophys Res Commun. 2010;396:787-92 pubmed publisher
    ..vaccination is a promising means to achieve protective immunity and to avoid immunopathology in Japanese encephalitis virus (JEV) infection...
  24. Hua R, Chen N, Qin C, Deng Y, Ge J, Wang X, et al. Identification and characterization of a virus-specific continuous B-cell epitope on the PrM/M protein of Japanese Encephalitis Virus: potential application in the detection of antibodies to distinguish Japanese Encephalitis Virus infection from West. Virol J. 2010;7:249 pubmed publisher
    Differential diagnose of Japanese encephalitis virus (JEV) infection from other flavivirus especially West Nile virus (WNV) and Dengue virus (DV) infection was greatly hindered for the serological cross-reactive...
  25. Robinson J, Featherstone D, Vasanthapuram R, Biggerstaff B, Desai A, Ramamurty N, et al. Evaluation of three commercially available Japanese encephalitis virus IgM enzyme-linked immunosorbent assays. Am J Trop Med Hyg. 2010;83:1146-55 pubmed publisher
    We evaluated performance of three commercial Japanese encephalitis virus (JEV) IgM antibody capture enzyme-linked immunosorbent assay (MAC ELISA) kits with a panel of serological specimens collected during a surveillance project of acute ..
  26. Su H, Liao C, Lin Y. Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response. J Virol. 2002;76:4162-71 pubmed
    ..During Japanese encephalitis virus (JEV) infection, the lumen of the ER rapidly accumulates substantial amounts of viral proteins for ..
  27. Yang S, Liu M, Tien C, Chou S, Chang R. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interaction with 3' ends of Japanese encephalitis virus RNA and colocalization with the viral NS5 protein. J Biomed Sci. 2009;16:40 pubmed publisher
    Replication of the Japanese encephalitis virus (JEV) genome depends on host factors for successfully completing their life cycles; to do this, host factors have been recruited and/or relocated to the site of viral replication...
  28. Appaiahgari M, Vrati S. DNAzyme-mediated inhibition of Japanese encephalitis virus replication in mouse brain. Mol Ther. 2007;15:1593-9 pubmed
    b>Japanese encephalitis virus (JEV) is an arthropod-borne flavivirus with a single-stranded RNA genome containing non-coding regions (NCRs) at its 5' and 3'-ends...
  29. Biswas S, Ayachit V, Sapkal G, Mahamuni S, Gore M. Japanese encephalitis virus produces a CD4+ Th2 response and associated immunoprotection in an adoptive-transfer murine model. J Gen Virol. 2009;90:818-26 pubmed publisher
    Japanese encephalitis is an acute infection of the central nervous system caused by Japanese encephalitis virus (JEV)...
  30. Gupta N, Santhosh S, Babu J, Parida M, Rao P. Chemokine profiling of Japanese encephalitis virus-infected mouse neuroblastoma cells by microarray and real-time RT-PCR: implication in neuropathogenesis. Virus Res. 2010;147:107-12 pubmed publisher
    ..Pro- and anti-inflammatory agents targeted against chemokines such as CXCL10 may provide possible therapeutic modalities that can mitigate the morbidity associated with JEV infection of the CNS. ..
  31. Arya S, Agarwal N. Intriguing data on preservation of Japanese encephalitis virus RNA in dead mosquito tissues. Am J Trop Med Hyg. 2003;68:631; author reply 631 pubmed
  32. Xinglin J, Huanchun C, Xiang W, Changming Q. Quantitative and qualitative study of enzyme-linked immunosorbent assay to detect IgG against Japanese encephalitis virus in swine sera. Vet Res Commun. 2005;29:159-69 pubmed
    ..to investigate the application of indirect enzyme-linked immunoassay (ELISA) in detecting IgG against Japanese encephalitis virus in swine sera and the qualitative nature of this test...
  33. Schuller E, Jilma B, Voicu V, Golor G, Kollaritsch H, Kaltenböck A, et al. Long-term immunogenicity of the new Vero cell-derived, inactivated Japanese encephalitis virus vaccine IC51 Six and 12 month results of a multicenter follow-up phase 3 study. Vaccine. 2008;26:4382-6 pubmed publisher
    ..At 12 months, the SCR was 83% and the GMT (41) remained above the protective titer of 1:10. Most people immunized with IC51 will have protective neutralizing antibody levels for at least a year. ..
  34. Bharati K, Rani R, Vrati S. Evaluation of Japanese encephalitis virus DNA vaccine candidates in rhesus monkeys [Macaca mulatta]. Vaccine. 2009;27:10-6 pubmed publisher
    We have previously described DNA vaccine candidates against Japanese encephalitis virus (JEV) that were immunogenic in mice...
  35. Yang T, Shiu S, Chuang P, Lin Y, Wan L, Lan Y, et al. Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells. Virus Res. 2009;143:77-85 pubmed publisher
    b>Japanese encephalitis virus (JEV) causes severe neurological diseases with a high fatality rate...
  36. Yamanaka T, Tsujimura K, Kondo T, Yasuda W, Okada A, Noda K, et al. Isolation and genetic analysis of Japanese encephalitis virus from a diseased horse in Japan. J Vet Med Sci. 2006;68:293-5 pubmed
    ..The isolated JEV was classified into genotype I by nucleotide sequence analysis of the viral envelope gene. We believe that this is the first report of the genotype I strain being isolated from a horse. ..
  37. Chambers T, Jiang X, Droll D, Liang Y, Wold W, Nickells J. Chimeric Japanese encephalitis virus/dengue 2 virus infectious clone: biological properties, immunogenicity and protection against dengue encephalitis in mice. J Gen Virol. 2006;87:3131-40 pubmed
    A molecular clone of Japanese encephalitis virus (JE virus) was derived from the JE virus Nakayama strain and used to produce infectious JE virus in cell culture...
  38. Nidaira M, Taira K, Onodera I, Morikawa T, Itokazu K, Kudaka J, et al. Detection of Japanese encephalitis virus antibody in a pig on Yonaguni Island, where all pigs were slaughtered in 1997. Jpn J Infect Dis. 2007;60:70-1 pubmed
  39. Yang D, Kweon C, Kim B, Hwang I, Kang M, So B, et al. The seroprevalence of Japanese encephalitis virus in goats raised in Korea. J Vet Sci. 2007;8:197-9 pubmed
    b>Japanese encephalitis virus (JEV) causes a mosquitoborne viral zoonosis that is becoming increasingly important to public health in east and south Asia...
  40. Arunachalam N, Murty U, Narahari D, Balasubramanian A, Samuel P, Thenmozhi V, et al. Longitudinal studies of Japanese encephalitis virus infection in vector mosquitoes in Kurnool district, Andhra Pradesh, South India. J Med Entomol. 2009;46:633-9 pubmed
    ..carried out in Kurnool district, Andhra Pradesh state, south India, to identify the mosquito vectors of Japanese encephalitis virus (family Flaviviridae, genus Flavivirus, JEV)...
  41. Liu H, Chiou S, Chen W. Differential binding efficiency between the envelope protein of Japanese encephalitis virus variants and heparan sulfate on the cell surface. J Med Virol. 2004;72:618-24 pubmed
  42. Yang D, Kweon C, Kim B, Lim S, Kim S, Kwon J, et al. TaqMan reverse transcription polymerase chain reaction for the detection of Japanese encephalitis virus. J Vet Sci. 2004;5:345-51 pubmed
    ..transcription polymerase chain reaction (RT-PCR) using TaqMan probe was developed for detection of Japanese encephalitis virus (JEV)...
  43. Tsai K, Tsang S, Huang C, Chang R. Defective interfering RNAs of Japanese encephalitis virus found in mosquito cells and correlation with persistent infection. Virus Res. 2007;124:139-50 pubmed
    ..In this study we have identified for the first time the generation of DI RNAs of Japanese encephalitis virus in C6/36 mosquito cells...
  44. Li M, Fu S, Feng Y, Gao X, Zhai Y, Yu D, et al. [Molecular characterization of Japanese encephalitis virus isolated from Gansu province in 2008]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009;23:251-3 pubmed
    To sequence PrM and E gene of the Japanese encephalitis virus isolated from Gansu province in 2008 and analysis the genotype of new JEV isolates and the molecular characterization of E gene...
  45. Abraham S, Manjunath R. Induction of classical and nonclassical MHC-I on mouse brain astrocytes by Japanese encephalitis virus. Virus Res. 2006;119:216-20 pubmed
    ..using West Nile virus and other Flaviviruses, there are few reports that have examined the effects of Japanese encephalitis virus (JEV) infection directly on nonclassical and classical MHC expression in astrocytes...
  46. Kumar S, Kalita J, Saxena V, Khan M, Khanna V, Sharma S, et al. Some observations on the tropism of Japanese encephalitis virus in rat brain. Brain Res. 2009;1268:135-141 pubmed publisher
    ..Therefore, the present study was aimed to investigate the neuropathological changes following Japanese encephalitis virus (JEV) infection in rat at different time points...
  47. Liang J, Liao C, Liao J, Lee Y, Lin Y. A Japanese encephalitis virus vaccine candidate strain is attenuated by decreasing its interferon antagonistic ability. Vaccine. 2009;27:2746-54 pubmed publisher
    b>Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute encephalitis with high mortality in humans...
  48. Li Y, Xu M, Chen L, Zhu J, Ye J, Liu X, et al. Evaluation of murine bone marrow-derived dendritic cells loaded with inactivated virus as a vaccine against Japanese encephalitis virus. Vaccine. 2009;27:6004-10 pubmed publisher
    ..Design and development of safer and more efficacious vaccines against Japanese encephalitis virus (JEV) is a high-priority target in the world...
  49. Endy T, Nisalak A. Japanese encephalitis virus: ecology and epidemiology. Curr Top Microbiol Immunol. 2002;267:11-48 pubmed
  50. Chiou S, Chen W. Phenotypic changes in the Japanese encephalitis virus after one passage in Neuro-2a cells: generation of attenuated strains of the virus. Vaccine. 2007;26:15-23 pubmed
    ..As a result, most, if not all, low-virulent variants were generated in a relatively short time, all which have the potential to be live-attenuated vaccine candidates of the JE virus. ..
  51. Nett R, Campbell G, Reisen W. Potential for the emergence of Japanese encephalitis virus in California. Vector Borne Zoonotic Dis. 2009;9:511-7 pubmed publisher
    The potential risk for the introduction and establishment of Japanese encephalitis virus (JEV) within California is described based on the literature...
  52. van den Hurk A, Ritchie S, Johansen C, Mackenzie J, Smith G. Domestic pigs and Japanese encephalitis virus infection, Australia. Emerg Infect Dis. 2008;14:1736-8 pubmed publisher
    To determine whether relocating domestic pigs, the amplifying host of Japanese encephalitis virus (JEV), decreased the risk for JEV transmission to humans in northern Australia, we collected mosquitoes for virus detection...
  53. Nawa M, Takasaki T, Yamada K, Kurane I, Akatsuka T. Interference in Japanese encephalitis virus infection of Vero cells by a cationic amphiphilic drug, chlorpromazine. J Gen Virol. 2003;84:1737-41 pubmed
    Entry of Japanese encephalitis virus (JEV) into cells was analysed by using the vertebrate cell line Vero...
  54. Parida M, Santhosh S, Dash P, Tripathi N, Saxena P, Ambuj S, et al. Development and evaluation of reverse transcription-loop-mediated isothermal amplification assay for rapid and real-time detection of Japanese encephalitis virus. J Clin Microbiol. 2006;44:4172-8 pubmed
    ..isothermal amplification (RT-LAMP) assay is reported for rapid and real-time detection of Japanese encephalitis virus (JEV)...
  55. Hamano M, Lim C, Takagi H, Sawabe K, Kuwayama M, Kishi N, et al. Detection of antibodies to Japanese encephalitis virus in the wild boars in Hiroshima prefecture, Japan. Epidemiol Infect. 2007;135:974-7 pubmed
    ..The sera were tested for antibodies to Japanese encephalitis virus (JEV) by IgM capture and IgG enzyme-linked immunosorbent assays (ELISA), and plaque reduction ..
  56. Saxena V, Mathur A, Krishnani N, Dhole T. An insufficient anti-inflammatory cytokine response in mouse brain is associated with increased tissue pathology and viral load during Japanese encephalitis virus infection. Arch Virol. 2008;153:283-92 pubmed
    Infection of the central nervous system with Japanese encephalitis virus (JEV) results in fatal encephalitis in humans...
  57. Chuang C, Chen W. Experimental evidence that RNA recombination occurs in the Japanese encephalitis virus. Virology. 2009;394:286-97 pubmed publisher
    ..It was concluded that because RNA recombination generates genetic diversity in the JE virus, this must be considered particularly in studies of viral evolution, epidemiology, and possible vaccine safety. ..
  58. Yoshida Y, Tabei Y, Hasegawa M, Nagashima M, Morozumi S. Genotypic analysis of Japanese encephalitis virus strains isolated from swine in Tokyo, Japan. Jpn J Infect Dis. 2005;58:259-61 pubmed
  59. Verma S, Kumar S, Gupta N, Vedi S, Bhattacharya S, Lakshmana Rao P. Bacterially expressed recombinant envelope protein domain III of Japanese encephalitis virus (rJEV-DIII) elicits Th1 type of immune response in BALB/c mice. Vaccine. 2009;27:6905-9 pubmed publisher
    ..Envelope protein domain III of Japanese encephalitis virus is involved in binding to host receptors and it contains specific epitopes that elicit virus-..
  60. Lee E, Lobigs M. Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus. J Virol. 2002;76:4901-11 pubmed
    ..The in vivo mechanism for virulence attenuation of laboratory-derived variants of two flaviviruses in the Japanese encephalitis virus (JEV) serocomplex is described...
  61. Yun S, Kim S, Choi W, Nam J, Ju Y, Park K, et al. Molecular characterization of the full-length genome of the Japanese encephalitis viral strain K87P39. Virus Res. 2003;96:129-40 pubmed
    We have determined the complete nucleotide and deduced amino acid sequences of the Japanese encephalitis virus (JEV) strain K87P39, isolated from a pool of circulating Culex tritaeniorhynchus mosquitoes in Korea...
  62. Mackenzie J. Emerging zoonotic encephalitis viruses: lessons from Southeast Asia and Oceania. J Neurovirol. 2005;11:434-40 pubmed
    ..Most of these viruses are zoonotic, either being arthropod-borne viruses or bat-borne viruses. Thus Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, has spread through the Indonesian archipelago to Papua New Guinea (..
  63. Nga P, del Carmen Parquet M, Cuong V, Ma S, Hasebe F, Inoue S, et al. Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia. J Gen Virol. 2004;85:1625-31 pubmed
    This study analyses the evolutionary relatedness of 16 Japanese encephalitis virus (JEV) isolates (nine from Vietnam and seven from Japan) to previously published JEV strains using E gene sequence data...
  64. Bharati K, Vrati S. Japanese encephalitis: development of new candidate vaccines. Expert Rev Anti Infect Ther. 2006;4:313-24 pubmed
    ..The disease is caused by a Flavivirus named Japanese encephalitis virus that is spread to humans by mosquitoes...
  65. Lin C, Cheng C, Yang T, Li S, Cheng M, Wan L, et al. Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. Virus Res. 2008;137:49-55 pubmed publisher
    The interferon (IFN) antagonists of Japanese encephalitis virus (JEV) proteins contribute to the JE pathogenesis. Most flavivirus non-structural (NS) proteins correlate with virus-induced inflammation and immune escape...
  66. Shrivastva A, Tripathi N, Parida M, Dash P, Jana A, Lakshmana Rao P. Comparison of a dipstick enzyme-linked immunosorbent assay with commercial assays for detection of Japanese encephalitis virus-specific IgM antibodies. J Postgrad Med. 2008;54:181-5 pubmed
    ..Japanese encephalitis (JE) is a major public health concern in Asia including India...
  67. Chen C, Ou Y, Lin S, Raung S, Liao S, Lai C, et al. Glial activation involvement in neuronal death by Japanese encephalitis virus infection. J Gen Virol. 2010;91:1028-37 pubmed publisher
    ..Although substantial activation of glia is observed in Japanese encephalitis virus (JEV)-induced Japanese encephalitis, the inflammatory responses and consequences of astrocytes and ..
  68. Solomon T, Vaughn D. Pathogenesis and clinical features of Japanese encephalitis and West Nile virus infections. Curr Top Microbiol Immunol. 2002;267:171-94 pubmed
  69. Yamamoto A, Nakayama M, Kurosawa Y, Sugo K, Karasawa H, Ogawa T, et al. Development of a particle agglutination assay system for detecting Japanese encephalitis virus-specific human IgM, using hydroxyapatite-coated nylon beads. J Virol Methods. 2002;104:195-201 pubmed
    b>Japanese encephalitis virus-specific IgM is a reliable indicator for serodiagnosis of Japanese encephalitis. A particle agglutination (PA) assay system was developed to detect anti-Japanese encephalitis virus IgM in human serum samples...
  70. Gupta N, Lomash V, Rao P. Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity. J Clin Virol. 2010;49:4-10 pubmed publisher
    Host immune response particularly through the induction of proinflammatory cytokines and chemokines in Japanese encephalitis virus infection has not been clearly understood in relation with pathogenicity and disease severity...
  71. Mackenzie J, Johansen C, Ritchie S, Van Den Hurk A, Hall R. Japanese encephalitis as an emerging virus: the emergence and spread of Japanese encephalitis virus in Australasia. Curr Top Microbiol Immunol. 2002;267:49-73 pubmed
  72. Kurane I. Immune responses to Japanese encephalitis virus. Curr Top Microbiol Immunol. 2002;267:91-103 pubmed
  73. Solomon T, Ni H, Beasley D, Ekkelenkamp M, Cardosa M, Barrett A. Origin and evolution of Japanese encephalitis virus in southeast Asia. J Virol. 2003;77:3091-8 pubmed
    ..Four genotypes of Japanese encephalitis virus (JEV) are presently recognized (representatives of genotypes I to III have been fully sequenced), but ..
  74. Wu S, Lin C, Lee S, Lian W. Phenotypic and genotypic characterization of the neurovirulence and neuroinvasiveness of a large-plaque attenuated Japanese encephalitis virus isolate. Microbes Infect. 2003;5:475-80 pubmed
    The virulent phenotypes of Japanese encephalitis virus (JEV) can be divided into neuroinvasiveness (NI) and neurovirulence (NV)...
  75. Kuwayama M, Ito M, Takao S, Shimazu Y, Fukuda S, Miyazaki K, et al. Japanese encephalitis virus in meningitis patients, Japan. Emerg Infect Dis. 2005;11:471-3 pubmed
    Cerebrospinal fluid specimens from 57 patients diagnosed with meningitis were tested for Japanese encephalitis virus. Total RNA was extracted from the specimens and amplified...
  76. Yamanaka A, Mulyatno K, Susilowati H, Hendrianto E, Utsumi T, Amin M, et al. Prevalence of antibodies to Japanese encephalitis virus among pigs in Bali and East Java, Indonesia, 2008. Jpn J Infect Dis. 2010;63:58-60 pubmed
    b>Japanese encephalitis virus (JEV) is a fatal disease in Asia. Pigs are considered to be the effective amplifying host for JEV in the peridomestic environment...
  77. Yasui K. Neuropathogenesis of Japanese encephalitis virus. J Neurovirol. 2002;8 Suppl 2:112-4 pubmed
    In the central nervous system, the Japanese encephalitis virus can replicate only in neurons. The mechanism of the type of neurotropism was analyzed...
  78. Saini M, Vrati S. A Japanese encephalitis virus peptide present on Johnson grass mosaic virus-like particles induces virus-neutralizing antibodies and protects mice against lethal challenge. J Virol. 2003;77:3487-94 pubmed
    Protection against Japanese encephalitis virus (JEV) is antibody dependent, and neutralizing antibodies alone are sufficient to impart protection...
  79. Vashist S, Anantpadma M, Sharma H, Vrati S. La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus replication. J Gen Virol. 2009;90:1343-52 pubmed publisher
    b>Japanese encephalitis virus (JEV) genome is a single-stranded, positive-sense RNA with non-coding regions (NCRs) of 95 and 585 bases at its 5' and 3' ends, respectively...
  80. Gao N, Chen W, Zheng Q, Fan D, Zhang J, Chen H, et al. Co-expression of Japanese encephalitis virus prM-E-NS1 antigen with granulocyte-macrophage colony-stimulating factor enhances humoral and anti-virus immunity after DNA vaccination. Immunol Lett. 2010;129:23-31 pubmed publisher
    b>Japanese encephalitis virus (JEV) is an agent of Japanese encephalitis, and granulocyte-macrophage colony-stimulating factor (GM-CSF) is an attractive DNA vaccine adjuvant for its antigen presentation...
  81. Aleyas A, Han Y, George J, Kim B, Kim K, Lee C, et al. Multifront assault on antigen presentation by Japanese encephalitis virus subverts CD8+ T cell responses. J Immunol. 2010;185:1429-41 pubmed publisher
    b>Japanese encephalitis virus (JEV) is a frequent cause of acute and epidemic viral encephalitis...
  82. Ren J, Ding T, Zhang W, Song J, Ma W. Does Japanese encephalitis virus share the same cellular receptor with other mosquito-borne flaviviruses on the C6/36 mosquito cells?. Virol J. 2007;4:83 pubmed publisher
    b>Japanese encephalitis virus (JEV) is a member of mosquito-borne Flaviviridae. To date, the mechanisms of the early events of JEV infection remain poorly understood, and the cellular receptors are unidentified...
  83. Yun S, Kim S, Rice C, Lee Y. Development and application of a reverse genetics system for Japanese encephalitis virus. J Virol. 2003;77:6450-65 pubmed
    b>Japanese encephalitis virus (JEV) is a common agent of viral encephalitis that causes high mortality and morbidity among children...
  84. Kaur R, Vrati S. Development of a recombinant vaccine against Japanese encephalitis. J Neurovirol. 2003;9:421-31 pubmed
    ..The disease is caused by a mosquito-borne virus known as Japanese encephalitis virus (JEV)...
  85. Mishra M, Kumawat K, Basu A. Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines. Cell Biol Int. 2008;32:1506-13 pubmed publisher
    ..We have shown that Japanese encephalitis virus (JEV) infection causes morphological and functional changes in astrocytic cell-lines...
  86. Li P, Cao R, Zheng Q, Liu J, Li Y, Wang E, et al. Enhancement of humoral and cellular immunity in mice against Japanese encephalitis virus using a DNA prime-protein boost vaccine strategy. Vet J. 2010;183:210-6 pubmed publisher
    A synthetic multi-epitope gene containing critical epitopes of the Japanese encephalitis virus (JEV) envelope gene was cloned into both prokaryotic and eukaryotic expression vectors...
  87. Nitatpattana N, Apiwathnasorn C, Barbazan P, Leemingsawat S, Yoksan S, Gonzalez J. First isolation of Japanese encephalitis from Culex quinquefasciatus in Thailand. Southeast Asian J Trop Med Public Health. 2005;36:875-8 pubmed
    ..Two pools of Cx. quinquefasciatus yielded a JE virus isolation. This represents the first report of JE virus isolation from Cx. quinquefasciatus in Thailand. ..
  88. van den Hurk A, Ritchie S, Mackenzie J. Ecology and geographical expansion of Japanese encephalitis virus. Annu Rev Entomol. 2009;54:17-35 pubmed publisher
    b>Japanese encephalitis virus (JEV) (Flavivirus: Flaviviridae) is a leading cause of encephalitis in eastern and southern Asia. The virus is maintained in a zoonotic cycle between ardeid wading birds and/or pigs and Culex mosquitoes...
  89. Fan J, Luo J, Chen L, Teng M, Bu D, Wang F, et al. Genetic analysis of strains of Japanese Encephalitis Virus isolated from swine in central China. Virus Genes. 2010;40:357-61 pubmed publisher
    In this study, four strains of Japanese Encephalitis Virus (JEV) were isolated from the cerebrospinal fluid of aborted fetuses or stillborn piglets collected randomly from a number of piggeries in central China...
  90. Chang G, Hunt A, Holmes D, Springfield T, Chiueh T, Roehrig J, et al. Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and Japanese encephalitis virus. Virology. 2003;306:170-80 pubmed
    ..Eleven of twelve 2-day-old neonatal mice, derived from a pCB8D2-2J-2-9-1 immunized female mouse, survived intraperitoneal challenge of DEN-2 New Guinea C virus...
  91. Uchil P, Satchidanandam V. Characterization of RNA synthesis, replication mechanism, and in vitro RNA-dependent RNA polymerase activity of Japanese encephalitis virus. Virology. 2003;307:358-71 pubmed
  92. Feng G, Liu N, Zhou Y, Zhai Y, Li X, Dou X. Immunologic analysis induced by DNA vaccine encoding E protein of Beijing-1 strain derived from Japanese encephalitis virus. Intervirology. 2007;50:93-8 pubmed
    ..DNA immunization efficacy encoding prME and E proteins of a different strain (JaGAr-01) derived from Japanese encephalitis virus. This study aimed to construct a recombinant encoding E protein of the Beijing-1 strain derived from ..