rabbit hemorrhagic disease virus

Summary

Summary: A species in the genus LAGOVIRUS which causes hemorrhagic disease, including hemorrhagic septicemia, in rabbits.

Top Publications

  1. Gromadzka B, Szewczyk B, Konopa G, Fitzner A, Kesy A. Recombinant VP60 in the form of virion-like particles as a potential vaccine against rabbit hemorrhagic disease virus. Acta Biochim Pol. 2006;53:371-6 pubmed
    b>Rabbit hemorrhagic disease virus (RHDV) which causes a highly contagious disease of wild and domestic rabbits belongs to the family Caliciviridae. It is a small, positive single-stranded RNA virus with a genome of 7...
  2. McIntosh M, Behan S, Mohamed F, Lu Z, Moran K, Burrage T, et al. A pandemic strain of calicivirus threatens rabbit industries in the Americas. Virol J. 2007;4:96 pubmed
    ..b>Rabbit Hemorrhagic Disease virus (RHDV) - a Lagovirus belonging to the family Caliciviridae is the etiological agent of RHD...
  3. Matiz K, Ursu K, Kecskemeti S, Bajmócy E, Kiss I. Phylogenetic analysis of rabbit haemorrhagic disease virus (RHDV) strains isolated between 1988 and 2003 in eastern Hungary. Arch Virol. 2006;151:1659-66 pubmed
    ..These findings were supported by the alignments of the deduced amino acid sequences of the VP60 gene and strongly suggest the presence of the RHDVa subtype in Hungary. ..
  4. Calvete C. Modeling the effect of population dynamics on the impact of rabbit hemorrhagic disease. Conserv Biol. 2006;20:1232-41 pubmed
  5. Gall A, Schirrmeier H. Persistence of rabbit haemorrhagic disease virus genome in vaccinated rabbits after experimental infection. J Vet Med B Infect Dis Vet Public Health. 2006;53:358-62 pubmed
    ..The results presented in this study are an urgent evidence for the existence of carrier animals as an important factor in the epidemiology of RHD. ..
  6. Peacey M, Wilson S, Perret R, Ronchese F, Ward V, Young V, et al. Virus-like particles from rabbit hemorrhagic disease virus can induce an anti-tumor response. Vaccine. 2008;26:5334-7 pubmed publisher
    ..We have chemically conjugated ovalbumin (OVA) or OVA-derived CD4 (OTII) and CD8 (OTI) epitopes, to rabbit hemorrhagic disease virus (RHDV) VLP...
  7. Ros Bascuñana C, Nowotny N, Belak S. Detection and differentiation of rabbit hemorrhagic disease and European brown hare syndrome viruses by amplification of VP60 genomic sequences from fresh and fixed tissue specimens. J Clin Microbiol. 1997;35:2492-5 pubmed
    ..transcription-PCR (RT-PCR) assays have been developed for the detection and differentiation of rabbit hemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV), two closely related caliciviruses...
  8. Greenslade E, Weinstein P, Woodward A, Capucci L, Salmond C, Beasley R. A serological survey of antibodies to rabbit haemorrhagic disease virus (rabbit calicivirus disease) in two rural Central Otago communities. N Z Med J. 2001;114:55-7 pubmed
    ..CONCLUSIONS. No serological evidence of infection with RHDV was found in a cohort including many heavily exposed individuals. ..
  9. Le Gall Reculé G, Zwingelstein F, Laurent S, de Boisseson C, Portejoie Y, Rasschaert D. Phylogenetic analysis of rabbit haemorrhagic disease virus in France between 1993 and 2000, and the characterisation of RHDV antigenic variants. Arch Virol. 2003;148:65-81 pubmed
    ..Multiple sequence alignments of the VP60 gene and antigenic analysis with monoclonal antibodies demonstrated that these French isolates are two new isolates of the RHDV variant. ..

More Information

Publications112 found, 100 shown here

  1. Gall A, Hoffmann B, Teifke J, Lange B, Schirrmeier H. Persistence of viral RNA in rabbits which overcome an experimental RHDV infection detected by a highly sensitive multiplex real-time RT-PCR. Vet Microbiol. 2007;120:17-32 pubmed
    ..Therefore, further experiments are necessary to prove that the persistence of RNA is linked with the persistence of infectious virus particles. ..
  2. van de Bildt M, van Bolhuis G, van Zijderveld F, van Riel D, Drees J, Osterhaus A, et al. Confirmation and phylogenetic analysis of rabbit hemorrhagic disease virus in free-living rabbits from the Netherlands. J Wildl Dis. 2006;42:808-12 pubmed
    ..Although rabbit hemorrhagic disease virus (RHDV) infection has been implicated as a possible cause of this decline, the definitive diagnosis ..
  3. Esteves P, Abrantes J, Carneiro M, M ller A, Thompson G, van der Loo W. Detection of positive selection in the major capsid protein VP60 of the rabbit haemorrhagic disease virus (RHDV). Virus Res. 2008;137:253-6 pubmed publisher
    ..The detection of PSCs should allow a better understanding of the interaction between RHDV and the rabbit immune system...
  4. Mach n A, Mart n Alonso J, Dalton K, Parra F. Functional differences between precursor and mature forms of the RNA-dependent RNA polymerase from rabbit hemorrhagic disease virus. J Gen Virol. 2009;90:2114-8 pubmed publisher
    The genome region encoding the RNA-dependent RNA polymerase 3CD-like precursor from rabbit hemorrhagic disease virus (RHDV) (isolate AST/89) was cloned and expressed in Escherichia coli using polyhistidine fusion-based vectors...
  5. Asgari S, Hardy J, Sinclair R, Cooke B. Field evidence for mechanical transmission of rabbit haemorrhagic disease virus (RHDV) by flies (Diptera:Calliphoridae) among wild rabbits in Australia. Virus Res. 1998;54:123-32 pubmed
    ..We conclude that flyspots are a major potential source of the virus for oral or conjunctival transmission of the virus to rabbits. ..
  6. Capucci L, Fallacara F, Grazioli S, Lavazza A, Pacciarini M, Brocchi E. A further step in the evolution of rabbit hemorrhagic disease virus: the appearance of the first consistent antigenic variant. Virus Res. 1998;58:115-26 pubmed
    b>Rabbit hemorrhagic disease virus (RHDV) is a noncultivable calicivirus that infects rabbits (Oryctolagus cuniculus) and causes epidemics of an acute fatal hepatitis...
  7. López Vázquez A, Martín Alonso J, Parra F. Characterisation of the RNA-dependent RNA polymerase from Rabbit hemorrhagic disease virus produced in Escherichia coli. Arch Virol. 2001;146:59-69 pubmed
    ..has been experimentally demonstrated in only a handful of these viral proteins, including that from Rabbit hemorrhagic disease virus. Studies from our laboratory have reported that RHDV RNA polymerase produced in Escherichia coli was ..
  8. McColl K, Merchant J, Hardy J, Cooke B, Robinson A, Westbury H. Evidence for insect transmission of rabbit haemorrhagic disease virus. Epidemiol Infect. 2002;129:655-63 pubmed
    ..These data, combined with previously published information on fly biology, suggested that flies, particularly bushflies, may be involved in the transmission of RHD virus. Other possible routes of spread were not assessed in this study. ..
  9. Ferreira P, Costa e Silva A, Monteiro E, Oliveira M, Aguas A. Transient decrease in blood heterophils and sustained liver damage caused by calicivirus infection of young rabbits that are naturally resistant to rabbit haemorrhagic disease. Res Vet Sci. 2004;76:83-94 pubmed
    ..We propose that, although resistant to RHD, young rabbits infected by calicivirus may be long-term carriers of the infectious agent and, thus, become a major source of transmission of the virus. ..
  10. Forrester N, Abubakr M, Abu Elzein E, al Afaleq A, Housawi F, Moss S, et al. Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia?. Virology. 2006;344:277-82 pubmed
  11. Farnos O, Rodriguez M, Chiong M, Parra F, Boue O, Lorenzo N, et al. The recombinant rabbit hemorrhagic disease virus VP60 protein obtained from Pichia pastoris induces a strong humoral and cell-mediated immune response following intranasal immunization in mice. Vet Microbiol. 2006;114:187-95 pubmed
    ..n.) vaccination with the recombinant VP60 capsid protein from rabbit hemorrhagic disease virus (RHDV) expressed at high levels in Pichia pastoris...
  12. Liu G, Zhang Y, Ni Z, Yun T, Sheng Z, Liang H, et al. Recovery of infectious rabbit hemorrhagic disease virus from rabbits after direct inoculation with in vitro-transcribed RNA. J Virol. 2006;80:6597-602 pubmed
    We report the first full-length infectious clone of strain JX/CHA/97 of rabbit hemorrhagic disease virus (RHDV). The transcripts from the full-length cDNA clones were infectious when they were directly injected into rabbits...
  13. Liu G, Ni Z, Yun T, Yu B, Chen L, Zhao W, et al. A DNA-launched reverse genetics system for rabbit hemorrhagic disease virus reveals that the VP2 protein is not essential for virus infectivity. J Gen Virol. 2008;89:3080-5 pubmed publisher
    b>Rabbit hemorrhagic disease virus (RHDV), a member of the family Caliciviridae comprising positive-stranded RNA viruses, is a highly virulent pathogen of rabbits...
  14. Fernández Fernández M, Mourino M, Rivera J, Rodriguez F, Plana Duran J, Garcia J. Protection of rabbits against rabbit hemorrhagic disease virus by immunization with the VP60 protein expressed in plants with a potyvirus-based vector. Virology. 2001;280:283-91 pubmed
    ..The VP60 structural protein of rabbit hemorrhagic disease virus (RHDV) was also successfully expressed by making use of the PPV-NK vector...
  15. Morales M, Bárcena J, Ramirez M, Boga J, Parra F, Torres J. Synthesis in vitro of rabbit hemorrhagic disease virus subgenomic RNA by internal initiation on (-)sense genomic RNA: mapping of a subgenomic promoter. J Biol Chem. 2004;279:17013-8 pubmed
    b>Rabbit hemorrhagic disease virus (RHDV), a positive-strand RNA virus, is the type species of the Lagovirus within the Caliciviridae. In addition to the genomic RNA of 7.4 kb, a subgenomic mRNA (sgRNA) of 2...
  16. Bárcena J, Verdaguer N, Roca R, Morales M, Angulo I, Risco C, et al. The coat protein of Rabbit hemorrhagic disease virus contains a molecular switch at the N-terminal region facing the inner surface of the capsid. Virology. 2004;322:118-34 pubmed
    ..Here we describe this structural polymorphism in a viral protein, the coat protein of Rabbit hemorrhagic disease virus (RHDV), which is required during virus capsid assembly...
  17. Sanchez Campos S, Alvarez M, Culebras J, Gonzalez Gallego J, Tunon M. Pathogenic molecular mechanisms in an animal model of fulminant hepatic failure: rabbit hemorrhagic viral disease. J Lab Clin Med. 2004;144:215-22 pubmed
    ..in the pathogenesis of fulminant hepatic failure are present in rabbits experimentally infected with rabbit hemorrhagic disease virus (RHDV)...
  18. San Miguel B, Alvarez M, Culebras J, Gonzalez Gallego J, Tuñón M. N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure. Apoptosis. 2006;11:1945-57 pubmed
    ..This work was undertaken to investigate whether treatment with N-acetyl-cysteine (NAC) prevents oxidative stress and inhibits the apoptotic pathways in an animal model of fulminant hepatic failure...
  19. Farnos O, Boue O, Parra F, Martín Alonso J, Valdés O, Joglar M, et al. High-level expression and immunogenic properties of the recombinant rabbit hemorrhagic disease virus VP60 capsid protein obtained in Pichia pastoris. J Biotechnol. 2005;117:215-24 pubmed
    The VP60 capsid protein from rabbit hemorrhagic disease virus (RHDV) (Spanish isolate AST/89) was cloned and expressed in Pichia pastoris. The transformed yeast was grown at high cell density and an expression level of about 1...
  20. Forrester N, Trout R, Gould E. Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, Eire. Virology. 2007;358:18-22 pubmed
  21. Tian L, Liao J, Li J, Zhou W, Zhang X, Wang H. Isolation and identification of a non-haemagglutinating strain of rabbit hemorrhagic disease virus from China and sequence analysis for the VP60 Gene. Virus Genes. 2007;35:745-52 pubmed
    A variant strain of rabbit hemorrhagic disease virus, designated "whn-1", was isolated and identified in China...
  22. Forrester N, Moss S, Turner S, Schirrmeier H, Gould E. Recombination in rabbit haemorrhagic disease virus: possible impact on evolution and epidemiology. Virology. 2008;376:390-6 pubmed publisher
    ..These observations imply that recombination may play a significant role in the evolution, epidemiology and diversity of RHDV. ..
  23. Yang L, Wang F, Hu B, Xue J, Hu Y, Zhou B, et al. Development of an RT-PCR for rabbit hemorrhagic disease virus (RHDV) and the epidemiology of RHDV in three eastern provinces of China. J Virol Methods. 2008;151:24-9 pubmed publisher
    Reverse transcriptase polymerase chain reaction (RT-PCR) for the diagnosis of rabbit hemorrhagic disease virus (RHDV) was developed by examining sensitivity and specificity...
  24. Chen L, Liu G, Ni Z, Yu B, Yun T, Song Y, et al. Minor structural protein VP2 in rabbit hemorrhagic disease virus downregulates the expression of the viral capsid protein VP60. J Gen Virol. 2009;90:2952-5 pubmed publisher
    b>Rabbit hemorrhagic disease virus (RHDV) has two structural proteins: the major capsid protein VP60 and the minor capsid protein VP2. VP2 is speculated to play an important role in the virus life cycle...
  25. Oem J, Lee K, Roh I, Lee K, Kim S, Kim H, et al. Identification and characterization of rabbit hemorrhagic disease virus genetic variants isolated in Korea. J Vet Med Sci. 2009;71:1519-23 pubmed
    Nine isolates of rabbit hemorrhagic disease virus (RHDV) were used for the genetic characterization of RHDV strains collected from rabbits in Korea between 2006 and 2008...
  26. Bertagnoli S, Gelfi J, Le Gall G, Boilletot E, Vautherot J, Rasschaert D, et al. Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein. J Virol. 1996;70:5061-6 pubmed
    Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease...
  27. Le Gall G, Arnauld C, Boilletot E, Morisse J, Rasschaert D. Molecular epidemiology of rabbit haemorrhagic disease virus outbreaks in France during 1988 to 1995. J Gen Virol. 1998;79 ( Pt 1):11-6 pubmed
    ..The possible evolution of RHDV is discussed. ..
  28. Angulo E, Cooke B. First synthesize new viruses then regulate their release? The case of the wild rabbit. Mol Ecol. 2002;11:2703-9 pubmed
    ..If international regulations are inadequate, molecular biologists and ecologists must consider the consequences of their research and advice beyond their own country to avoid unwanted impacts. ..
  29. White P, Trout R, Moss S, Desai A, Armesto M, Forrester N, et al. Epidemiology of rabbit haemorrhagic disease virus in the United Kingdom: evidence for seasonal transmission by both virulent and avirulent modes of infection. Epidemiol Infect. 2004;132:555-67 pubmed
    ..These findings suggest that many--perhaps most--strains of RHDV may be propagated through both 'pathogenic' and 'non-pathogenic' modes of behaviour. Transmission occurred predominantly during and just after the breeding season. ..
  30. Meyers G. Characterization of the sequence element directing translation reinitiation in RNA of the calicivirus rabbit hemorrhagic disease virus. J Virol. 2007;81:9623-32 pubmed
    ..The sequence mapping resulted in a refined model of the reinitiation mechanism leading to VP2 expression. ..
  31. Kerr P, Kitchen A, Holmes E. Origin and phylodynamics of rabbit hemorrhagic disease virus. J Virol. 2009;83:12129-38 pubmed publisher
    To determine the origin, phylogenetic relationships, and evolutionary dynamics of rabbit hemorrhagic disease virus (RHDV), we examined 210 partial and complete capsid gene nucleotide sequences...
  32. Kinnear M, Linde C. Capsid gene divergence in rabbit hemorrhagic disease virus. J Gen Virol. 2010;91:174-81 pubmed publisher
    The emergence and rapid global spread of rabbit hemorrhagic disease virus (RHDV) remains enigmatic despite two decades of study, largely due to the difficulties associated with modelling substitution processes of the RNA genome for ..
  33. Moss S, Turner S, Trout R, White P, Hudson P, Desai A, et al. Molecular epidemiology of Rabbit haemorrhagic disease virus. J Gen Virol. 2002;83:2461-7 pubmed
    ..The high stability of RHDV RNA is also demonstrated by showing that it can be amplified and sequenced from rabbit bone marrow samples collected at least 7 weeks after the animal has died. ..
  34. Thumfart J, Meyers G. Rabbit hemorrhagic disease virus: identification of a cleavage site in the viral polyprotein that is not processed by the known calicivirus protease. Virology. 2002;304:352-63 pubmed
    The positive-strand RNA genome of the calicivirus rabbit hemorrhagic disease virus (RHDV) contains one long open reading frame (ORF) covering almost 95% of the genomic RNA...
  35. Forrester N, Boag B, Moss S, Turner S, Trout R, White P, et al. Long-term survival of New Zealand rabbit haemorrhagic disease virus RNA in wild rabbits, revealed by RT-PCR and phylogenetic analysis. J Gen Virol. 2003;84:3079-86 pubmed
    ..Moreover, the co-circulation of other strains of RHDV in the same rabbit population, such as the Spanish strain, might also impact on their susceptibility to the bio-control agent. ..
  36. Henning J, Schnitzler F, Pfeiffer D, Davies P. Influence of weather conditions on fly abundance and its implications for transmission of rabbit haemorrhagic disease virus in the North Island of New Zealand. Med Vet Entomol. 2005;19:251-62 pubmed
    ..The influence of other climatic factors varied between fly species. Climate dependent variations in fly abundance may contribute to the risk of transmission of RHD, which occurred intermittently on the site during the study period. ..
  37. Ferreira P, Costa e Silva A, Aguas A. Liver disease in young rabbits infected by calicivirus through nasal and oral routes. Res Vet Sci. 2006;81:362-5 pubmed
    ..We conclude that the previously reported reduction of viral receptors in the epithelium of respiratory and digestive systems of young rabbits does not inhibit calicivirus from inducing liver disease in these hosts. ..
  38. Ferreira P, Dinis M, Costa e Silva A, Aguas A. Adult rabbits acquire resistance to lethal calicivirus infection by adoptive transfer of sera from infected young rabbits. Vet Immunol Immunopathol. 2008;121:364-9 pubmed
    ..We conclude that calicivirus infection of young rabbits induces specific anti-calicivirus antibodies that will protect them from RHD when they reach adulthood. ..
  39. Abrantes J, Esteves P, van der Loo W. Evidence for recombination in the major capsid gene VP60 of the rabbit haemorrhagic disease virus (RHDV). Arch Virol. 2008;153:329-35 pubmed publisher
    ..Phylogenetic analyses revealed two well separated groups. Clear evidence for recombination was found for the Hartmannsdorf strain which shows different phylogenetic profiles depending on the region of the capsid examined. ..
  40. Guillon P, Ruvoen Clouet N, Le Moullac Vaidye B, Marchandeau S, Le Pendu J. Association between expression of the H histo-blood group antigen, alpha1,2fucosyltransferases polymorphism of wild rabbits, and sensitivity to rabbit hemorrhagic disease virus. Glycobiology. 2009;19:21-8 pubmed publisher
    RHDV (rabbit hemorrhagic disease virus) is a highly virulent calicivirus that has become a major cause of mortality in wild rabbit populations (Oryctolagus cuniculus)...
  41. Muller A, Freitas J, Silva E, Le Gall Reculé G, Zwingelstein F, Abrantes J, et al. Evolution of rabbit haemorrhagic disease virus (RHDV) in the European rabbit (Oryctolagus cuniculus) from the Iberian Peninsula. Vet Microbiol. 2009;135:368-73 pubmed publisher
    ..No differences were observed in RHDV sequences obtained from geographic regions where the rabbit subspecies O. c. algirus prevails compared with those obtained from O. c. cuniculus. ..
  42. Meyers G, Wirblich C, Thiel H, Thumfart J. Rabbit hemorrhagic disease virus: genome organization and polyprotein processing of a calicivirus studied after transient expression of cDNA constructs. Virology. 2000;276:349-63 pubmed publisher
    b>Rabbit hemorrhagic disease virus (RHDV) belongs to the family Caliciviridae. Studies on this virus are hampered by the lack of a convenient cell culture system...
  43. Teifke J, Reimann I, Schirrmeier H. Subacute liver necrosis after experimental infection with rabbit haemorrhagic disease virus (RHDV). J Comp Pathol. 2002;126:231-4 pubmed
    ..These signs, observed in young rabbits given small doses of RHD virus, are interpreted as an unusual outcome of experimental inoculation. ..
  44. Tunon M, Sanchez Campos S, Garcia Ferreras J, Alvarez M, Jorquera F, Gonzalez Gallego J. Rabbit hemorrhagic viral disease: characterization of a new animal model of fulminant liver failure. J Lab Clin Med. 2003;141:272-8 pubmed
    ..a novel model of fulminant liver failure (FLF) by means of experimental infection of rabbits with the rabbit hemorrhagic disease virus (RHDV)...
  45. Farnos O, Rodriguez D, Valdes O, Chiong M, Parra F, Toledo J, et al. Molecular and antigenic characterization of rabbit hemorrhagic disease virus isolated in Cuba indicates a distinct antigenic subtype. Arch Virol. 2007;152:1215-21 pubmed
    Phylogenetic analyses conducted on isolates of rabbit hemorrhagic disease virus (RHDV) from throughout the world have shown well-defined genogroups comprising representative strains of the virus and antigenic variants...
  46. Gil F, Titarenko E, Terrada E, Arcalis E, Escribano J. Successful oral prime-immunization with VP60 from rabbit haemorrhagic disease virus produced in transgenic plants using different fusion strategies. Plant Biotechnol J. 2006;4:135-43 pubmed
    ..Mice fed with leaves of transgenic plants expressing VP60 were primed to a subimmunogenic baculovirus-derived vaccine single dose. This indicates that plants expressing VP60 antigen may be a new means for oral RHDV immunization. ..
  47. Forrester N, Boag B, Buckley A, Moureau G, Gould E. Co-circulation of widely disparate strains of rabbit haemorrhagic disease virus could explain localised epidemicity in the United Kingdom. Virology. 2009;393:42-8 pubmed publisher
  48. Sun J, Hu Y, Wang D, Zhang B, Liu J. Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. Vaccine. 2006;24:2343-8 pubmed
    ..All of cCIs and cCMs could markedly promote lymphocyte proliferation and enhance antibody titer in chickens, which was similar to oil adjuvant, the immunologic enhancement of cCIs were slightly superior to that of the cCMs. ..
  49. Velarde R, Cavadini P, Neimanis A, Cabezón O, Chiari M, Gaffuri A, et al. Spillover Events of Infection of Brown Hares (Lepus europaeus) with Rabbit Haemorrhagic Disease Type 2 Virus (RHDV2) Caused Sporadic Cases of an European Brown Hare Syndrome-Like Disease in Italy and Spain. Transbound Emerg Dis. 2017;64:1750-1761 pubmed publisher
    ..Our findings increase the knowledge on distribution, host range and epidemiology of RHDV2...
  50. Le Pendu J, Abrantes J, Bertagnoli S, Guitton J, Le Gall Reculé G, Lopes A, et al. Proposal for a unified classification system and nomenclature of lagoviruses. J Gen Virol. 2017;98:1658-1666 pubmed publisher
    ..We propose that an international working group could coordinate the nomenclature of lagoviruses and any proposals for revision. ..
  51. Hayes R, Richardson B. Biological control of the rabbit in Australia: lessons not learned?. Trends Microbiol. 2001;9:459-60 pubmed
    ..What can be learned from the way this system developed, and what has been learned, or not learned, from the mistakes made? Here, we look at these events and examine what insights can be gained from this history. ..
  52. Campagnolo E, Ernst M, Berninger M, Gregg D, Shumaker T, Boghossian A. Outbreak of rabbit hemorrhagic disease in domestic lagomorphs. J Am Vet Med Assoc. 2003;223:1151-5, 1128 pubmed
    ..The economic impact of the disease can be considerable; if the disease is suspected, it is imperative that the appropriate state or federal veterinarian's office be contacted immediately. ..
  53. Li J, Wang H, Tian L, Huang Y, Zhang X. [Isolation, identification and genome sequenceing of a rabbit hemorrhagic disease virus strain WHNRH]. Wei Sheng Wu Xue Bao. 2006;46:720-5 pubmed
    The rabbit hemorrhagic disease virus (RHDV) is a single-stranded positive-sense RNA virus of the family Caliciviridae with a high morbidity and mortality rates of about 90% in adult rabbits...
  54. Hall R, Mahar J, Read A, Mourant R, Piper M, Huang N, et al. A strain-specific multiplex RT-PCR for Australian rabbit haemorrhagic disease viruses uncovers a new recombinant virus variant in rabbits and hares. Transbound Emerg Dis. 2017;: pubmed publisher
    ..The impact of this novel recombinant on Australian wild lagomorph populations and its competitiveness in relation to circulating field strains, particularly GI.2, requires further studies...
  55. Frank A, Kessler H. Biophysics: the sweetest candy for the virus. Nature. 2008;452:822-3 pubmed publisher
  56. Laurent S, Kut E, Remy Delaunay S, Rasschaert D. Folding of the rabbit hemorrhagic disease virus capsid protein and delineation of N-terminal domains dispensable for assembly. Arch Virol. 2002;147:1559-71 pubmed
    b>Rabbit hemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV) are caliciviruses that produce severe symptoms and are lethal to rabbits and hares...
  57. Lopes A, Silvério D, Magalhães M, Areal H, Alves P, Esteves P, et al. Characterization of old RHDV strains by complete genome sequencing identifies a novel genetic group. Sci Rep. 2017;7:13599 pubmed publisher
    ..In Portugal, rabbit hemorrhagic disease virus (RHDV) was reported in 1989 and still causes enzootic outbreaks...
  58. Eden J, Read A, Duckworth J, Strive T, Holmes E. Resolving the Origin of Rabbit Hemorrhagic Disease Virus: Insights from an Investigation of the Viral Stocks Released in Australia. J Virol. 2015;89:12217-20 pubmed publisher
    To resolve the evolutionary history of rabbit hemorrhagic disease virus (RHDV), we performed a genomic analysis of the viral stocks imported and released as a biocontrol measure in Australia, as well as a global phylogenetic analysis...
  59. Ng K, Cherney M, Vazquez A, Machin A, Alonso J, Parra F, et al. Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J Biol Chem. 2002;277:1381-7 pubmed
    The structure of the RNA-dependent RNA polymerase (RdRP) from the rabbit hemorrhagic disease virus has been determined by x-ray crystallography to a 2.5-A resolution...
  60. Nicholson L, Mahar J, Strive T, Zheng T, Holmes E, Ward V, et al. Benign Rabbit Calicivirus in New Zealand. Appl Environ Microbiol. 2017;83: pubmed publisher
    The Czech v351 strain of rabbit hemorrhagic disease virus (RHDV1) is used in Australia and New Zealand as a biological control agent for rabbits, which are important and damaging introduced vertebrate pests in these countries...
  61. Cooke B. Rabbit haemorrhagic disease: field epidemiology and the management of wild rabbit populations. Rev Sci Tech. 2002;21:347-58 pubmed
    ..Altering the epidemiology of RHD in this manner would assist the management of wild rabbit populations either for conservation or pest control purposes. ..
  62. Martín Alonso J, Castañón S, Alonso P, Parra F, Ordás R. Oral immunization using tuber extracts from transgenic potato plants expressing rabbit hemorrhagic disease virus capsid protein. Transgenic Res. 2003;12:127-30 pubmed
    ..In this study, we report the production of the major structural protein VP60 of rabbit hemorrhagic disease virus in transgenic tubers of potato plants and its use as an oral immunogen in rabbits.
  63. Tokarz Deptuła B, Deptuła W. Dynamic alterations in peripheral blood lymphocytes in rabbits experimentally infected with VHD (viral hemorrhagic disease) virus--Polish strain Kr-1. Pol J Vet Sci. 2003;6:67-9 pubmed
    ..Results of the studies demonstrated that the Polish strain Kr-1 can be regarded as less immunogenic than the French strain, Fr-2. This may indicate the existence of immunotypes within VHD viruses. ..
  64. Ferreira P, Costa e Silva A, Oliveira M, Monteiro E, Cunha E, Aguas A. Severe leukopenia and liver biochemistry changes in adult rabbits after calicivirus infection. Res Vet Sci. 2006;80:218-25 pubmed
  65. García Lastra R, San Miguel B, Crespo I, Jorquera F, Alvarez M, Gonzalez Gallego J, et al. Signaling pathways involved in liver injury and regeneration in rabbit hemorrhagic disease, an animal model of virally-induced fulminant hepatic failure. Vet Res. 2010;41:2 pubmed publisher
    ..Data show the presence of molecular mechanisms contributing to liver damage and the lack of regeneration and they support the usefulness of this model to investigate novel therapeutical modalities in FHF. ..
  66. Zhu J, Miao Q, Tan Y, Guo H, Li C, Chen Z, et al. Extensive characterization of a lentiviral-derived stable cell line expressing rabbit hemorrhagic disease virus VPg protein. J Virol Methods. 2016;237:86-91 pubmed publisher
    b>Rabbit hemorrhagic disease virus (RHDV) is an important member of the caliciviridae family. Currently, no suitable tissue culture system is available for proliferating RHDV, which limits the study of its pathogenesis...
  67. Donaldson B, Al Barwani F, Pelham S, Young K, Ward V, Young S. Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer. J Immunother Cancer. 2017;5:69 pubmed publisher
    ..Chimaeric VLP containing multiple epitopes were found to confer an advantage for therapeutic vaccination in a model of colorectal cancer based on the prolongation of remission prior to tumour escape. ..
  68. Torres J, Ramirez M, Morales M, Barcena J, Vazquez B, Espuna E, et al. Safety evaluation of a recombinant myxoma-RHDV virus inducing horizontal transmissible protection against myxomatosis and rabbit haemorrhagic disease. Vaccine. 2000;19:174-82 pubmed
    ..No undesirable effects were detected upon administration to immunosuppressed or pregnant rabbits. The recombinant virus maintained its attenuated phenotype after 10 passages in vivo...
  69. Le Gall Reculé G, Zwingelstein F, Portejoie Y, Le Gall G. Immunocapture-RT-PCR assay for detection and molecular epidemiology studies of Rabbit Haemorrhagic Disease and European Brown Hare Syndrome viruses. J Virol Methods. 2001;97:49-57 pubmed
    ..A good correlation was found between ELISA and IC-RT-PCR results for Rabbit Haemorrhagic Disease diagnosis, whereas for European Brown Hare Syndrome diagnosis, the results confirmed the higher sensitivity of the molecular method. ..
  70. Greenslade E, Beasley R, Jennings L, Woodward A, Weinstein P. Has Coxiella burnetii (Q fever) been introduced into New Zealand?. Emerg Infect Dis. 2003;9:138-40 pubmed
  71. Ismail M, Mohamed M, El Sabagh I, Al Hammadi M. Emergence of new virulent rabbit hemorrhagic disease virus strains in Saudi Arabia. Trop Anim Health Prod. 2017;49:295-301 pubmed publisher
    ..The aim of this study was to investigate the emergence and pathogenicity of new rabbit hemorrhagic disease virus (RHDV) strains in Saudi Arabia. The pathogenicity was confirmed by inoculation in susceptible rabbits...
  72. Hall R, Capucci L, Matthaei M, Esposito S, Kerr P, Frese M, et al. An in vivo system for directed experimental evolution of rabbit haemorrhagic disease virus. PLoS ONE. 2017;12:e0173727 pubmed publisher
    ..These findings demonstrate proof-of-concept that RHDV evolution can be experimentally manipulated to select for virus variants with altered phenotypes, in this case partial immune escape. ..
  73. White P, Norman R, Hudson P. Epidemiological consequences of a pathogen having both virulent and avirulent modes of transmission: the case of rabbit haemorrhagic disease virus. Epidemiol Infect. 2002;129:665-77 pubmed
    ..Other pathogens may exhibit similar behaviour and the implications for emerging diseases in general are discussed. ..
  74. Yap Y, Zhang X, Danchin A. Relationship of SARS-CoV to other pathogenic RNA viruses explored by tetranucleotide usage profiling. BMC Bioinformatics. 2003;4:43 pubmed
    ..The congruence of the relationship outcomes with the known classification indicates that there exist phylogenetic signals in the tetra-nucleotide usage patterns, that is most prominent in the replicase open reading frames. ..
  75. Boots M, Hudson P, Sasaki A. Large shifts in pathogen virulence relate to host population structure. Science. 2004;303:842-4 pubmed
    ..This model provides an explanation for the rapid emergence of the highly virulent strains of rabbit hemorrhagic disease virus.
  76. Zheng X, Wang S, Zhang W, Liu X, Yi Y, Yang S, et al. Development of a VLP-based vaccine in silkworm pupae against rabbit hemorrhagic disease virus. Int Immunopharmacol. 2016;40:164-169 pubmed publisher
    b>Rabbit hemorrhagic disease virus (RHDV) is the etiological agent behind rabbit hemorrhagic disease (RHD), which is lethal and contagious in rabbits...
  77. Zheng T, Lu G, Napier A, Lockyer S. No virus replication in domestic cats fed with RHDV-infected rabbit livers. Vet Microbiol. 2003;95:61-73 pubmed
    ..Even though a large amount of RHDV has been used, cats did not show any signs of disease. Although abortive RHDV replication could not be ruled out, active RHDV replication was not demonstrated. ..
  78. Barcena J, Morales M, Vazquez B, Boga J, Parra F, Lucientes J, et al. Horizontal transmissible protection against myxomatosis and rabbit hemorrhagic disease by using a recombinant myxoma virus. J Virol. 2000;74:1114-23 pubmed
    ..The recombinant viruses showed a limited horizontal transmission capacity, either by direct contact or in a flea-mediated process, promoting immunization of contact uninoculated animals...
  79. Machin A, Martín Alonso J, Parra F. Identification of the amino acid residue involved in rabbit hemorrhagic disease virus VPg uridylylation. J Biol Chem. 2001;276:27787-92 pubmed
    The virus genome-linked protein (VPg) coding region from rabbit hemorrhagic disease virus (RHDV) (isolate AST/89) was expressed in Escherichia coli by using a glutathione S-transferase-based vector...
  80. Tokarz Deptuła B, Hukowska B, Deptuła W. Dynamic alterations in selected indices of non-specific cell-mediated immunity in rabbits experimentally infected with VHD (viral hemorrhagic disease) virus. Pol J Vet Sci. 2003;6:70-3 pubmed
    ..The results indicate that the applied strains exhibit different immune reactivities, which points to the presence of immunotypes within the virus. ..
  81. Lopes A, Blanco Aguiar J, Martin Alonso A, Leitão M, Foronda P, Mendes M, et al. Full genome sequences are key to disclose RHDV2 emergence in the Macaronesian islands. Virus Genes. 2018;54:1-4 pubmed publisher
    ..in "Virus Genes" (June 2017) reported the presence of the new variant of rabbit hemorrhagic disease virus (RHDV2) in the two larger islands of the archipelago of Madeira...
  82. Cooke B, Duncan R, McDonald I, Liu J, Capucci L, Mutze G, et al. Prior exposure to non-pathogenic calicivirus RCV-A1 reduces both infection rate and mortality from rabbit haemorrhagic disease in a population of wild rabbits in Australia. Transbound Emerg Dis. 2018;65:e470-e477 pubmed publisher
    ..The methods we describe for analysing field data gave far greater insights into epidemiological processes and virus interactions than gained from reporting basic seroprevalence rates alone. ..
  83. Thiel H, Konig M. Caliciviruses: an overview. Vet Microbiol. 1999;69:55-62 pubmed
    ..Amongst them are vesicular exanthema virus of swine (VESV), feline calicivirus, rabbit hemorrhagic disease virus (RHDV), and Norwalk and Sapporo-like viruses; the latter viruses cause gastroenteritis in man...
  84. Marchandeau S, Bertagnoli S, Peralta B, Boucraut Baralon C, Letty J, Reitz F. Possible interaction between myxomatosis and calicivirosis related to rabbit haemorrhagic disease affecting the European rabbit. Vet Rec. 2004;155:589-92 pubmed
    ..1 and 8.4 times higher than the odds of a rabbit being seronegative to myxoma virus and seropositive to RHD. The year and bodyweight had significant effects for myxomatosis in one area and for RHD in both areas...
  85. Pérez Filgueira D, Resino Talaván P, Cubillos C, Angulo I, Barderas M, Barcena J, et al. Development of a low-cost, insect larvae-derived recombinant subunit vaccine against RHDV. Virology. 2007;364:422-30 pubmed
    Vaccine antigens against rabbit hemorrhagic disease virus (RHDV) are currently derived from inactivated RHDV obtained from livers of experimentally infected rabbits. Several RHDV-derived recombinant immunogens have been reported...
  86. Henning J, Alley M. Crypt abscesses in the caeca of feral rabbits in a rabbit haemorrhagic disease endemic region of New Zealand. N Z Vet J. 2007;55:239-43 pubmed
    ..Alternatively, association with season of birth may represent rabbits that were of similar age in a later stage of their lives, when they became exposed to the cause of the lesions, which remains unidentified. ..
  87. Fouchet D, Le Pendu J, Guitton J, Guiserix M, Marchandeau S, Pontier D. Evolution of microparasites in spatially and genetically structured host populations: the example of RHDV infecting rabbits. J Theor Biol. 2009;257:212-27 pubmed publisher
    ..Finally, we study how different demographic and epidemiologic parameters affect the coevolution between the rabbit and RHDV. ..
  88. Kimura T, Mitsui I, Okada Y, Furuya T, Ochiai K, Umemura T, et al. Distribution of rabbit haemorrhagic disease virus RNA in experimentally infected rabbits. J Comp Pathol. 2001;124:134-41 pubmed
    ..These results suggest that viral replication occurs not only in hepatocytes but also in macrophages. The infected macrophages may contribute to viral dissemination in RHD. ..
  89. Henning J, Davies P. A serial cross-sectional study of the prevalence of rabbit haemorrhagic disease on three farms in the lower North Island of New Zealand. N Z Vet J. 2005;53:149-53 pubmed
    ..Microclimate and vegetation influencing abundance of insect vectors for RHDV and intrinsic population-related factors like rabbit breeding behaviour are also likely to be involved in local patterns of spread. ..
  90. Liu G, Ni Z, Yun T, Yu B, Zhu J, Hua J, et al. [Construction of rabbit hemorrhagic disease virus replicons and its replication in RK-13 cells]. Bing Du Xue Bao. 2007;23:481-4 pubmed
    ..Besides, the results also suggested that the capsid protein which is the structural protein of RHDV is necessary for maintaining the viral infectivity. ..
  91. Bergin I, Wise A, Bolin S, Mullaney T, Kiupel M, Maes R. Novel calicivirus identified in rabbits, Michigan, USA. Emerg Infect Dis. 2009;15:1955-62 pubmed publisher
    ..in a Michigan rabbitry of a rabbit calicivirus distinct from the foreign animal disease agent, rabbit hemorrhagic disease virus (RHDV). The novel virus has been designated Michigan rabbit calicivirus (MRCV)...
  92. Rocha G, Alda F, Pagés A, Merchán T. Experimental transmission of rabbit haemorrhagic disease virus (RHDV) from rabbit to wild mice (Mus spretus and Apodemus sylvaticus) under laboratory conditions. Infect Genet Evol. 2017;47:94-98 pubmed publisher