lagovirus

Summary

Summary: A genus of the family CALICIVIRIDAE, associated with infections in rabbits and hares, responsible for epidemics with high mortality. RABBIT HEMORRHAGIC DISEASE VIRUS is the type species.

Top Publications

  1. Strive T, Wright J, Robinson A. Identification and partial characterisation of a new Lagovirus in Australian wild rabbits. Virology. 2009;384:97-105 pubmed publisher
    ..For the detection of this putative virus, a universal lagovirus PCR test was developed to screen a variety of different tissues of wild caught rabbits...
  2. Drews B, Szentiks C, Roellig K, Fickel J, Schroeder K, Duff J, et al. Epidemiology, control and management of an EBHS outbreak in captive hares. Vet Microbiol. 2011;154:37-48 pubmed publisher
    ..To estimate the effect of EBHS on reproduction, we compared the breeding seasons 2008 and 2009. Several possible sources of infection of the colony are discussed, but the definite cause could not be determined...
  3. Bárcena J, Guerra B, Angulo I, González J, Valcárcel F, Mata C, et al. Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles. Vet Res. 2015;46:106 pubmed publisher
    In 2010 a new Lagovirus related to rabbit haemorrhagic disease virus (RHDV) emerged in France and has since rapidly spread throughout domestic and wild rabbit populations of several European countries...
  4. Conley M, Emmott E, Orton R, Taylor D, Carneiro D, Murata K, et al. Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures. J Gen Virol. 2017;98:68-76 pubmed publisher
    ..Phylogenetic analysis confirms vesivirus 2117 as a vesivirus closely related to canine vesiviruses. We postulate that morphological differences in virion structure seen between vesivirus clades may reflect differences in receptor usage. ..
  5. Hu B, Wang F, Fan Z, Song Y, Abrantes J, Zuo Y, et al. Recombination between G2 and G6 strains of rabbit hemorrhagic disease virus (RHDV) in China. Arch Virol. 2017;162:269-272 pubmed publisher
    Rabbit hemorrhagic disease (RHD) is an acute fatal disease caused by the lagovirus rabbit hemorrhagic disease virus (RHDV), which was first reported in 1984 in China...
  6. Urakova N, Strive T, Frese M. RNA-Dependent RNA Polymerases of Both Virulent and Benign Rabbit Caliciviruses Induce Striking Rearrangement of Golgi Membranes. PLoS ONE. 2017;12:e0169913 pubmed publisher
    ..disease virus (RHDV) and the completely benign Rabbit calicivirus (RCV) are closely related members of the genus Lagovirus (family Caliciviridae)...
  7. Hall R, Mahar J, Read A, Mourant R, Piper M, Huang N, et al. A strain-specific multiplex RT-PCR for Australian rabbit haemorrhagic disease viruses uncovers a new recombinant virus variant in rabbits and hares. Transbound Emerg Dis. 2017;: pubmed publisher
    Rabbit haemorrhagic disease virus (RHDV, or GI.1) is a calicivirus in the genus Lagovirus that has been widely utilized in Australia as a biological control agent for the management of overabundant wild European rabbit (Oryctolagus ..
  8. Netzler N, Enosi Tuipulotu D, Eltahla A, Lun J, Ferla S, Brancale A, et al. Broad-spectrum non-nucleoside inhibitors for caliciviruses. Antiviral Res. 2017;146:65-75 pubmed publisher
    ..Thumb I (TI) site also inhibited transcriptional activities of six RdRps spanning the Norovirus, Sapovirus and Lagovirus genera of the Caliciviridae. These NNIs included JTK-109 (RdRp inhibition range: IC50 4.3-16...
  9. García Bocanegra I, Astorga R, Napp S, Huerta B, Carbonero A, Perea A, et al. Factors affecting the seroprevalence of lagovirus infection in wild rabbits (Oryctolagus cuniculus) in Southern Spain. Vet J. 2011;189:89-94 pubmed publisher
    ..carried out on wild rabbit (Oryctolagus cuniculus) populations in Southern Spain to assess the prevalence of lagovirus infection and to identify potentially associated risk factors...

More Information

Publications24

  1. Fitzner A, Niedbalski W. Phylogenetic analysis of rabbit haemorrhagic disease virus (RHDV) strains isolated in Poland. Arch Virol. 2017;162:3197-3203 pubmed publisher
    ..the main phylogenetic groups of classical RHDV, RHDVa and RHDV2 as well as the non-pathogenic rabbit lagovirus RCV, the BLAST software with blastn and MEGA6 with neighbour-joining method was applied...
  2. Le Gall Reculé G, Zwingelstein F, Fages M, Bertagnoli S, Gelfi J, Aubineau J, et al. Characterisation of a non-pathogenic and non-protective infectious rabbit lagovirus related to RHDV. Virology. 2011;410:395-402 pubmed publisher
    ..sequences related to RHDV have been detected in apparently healthy domestic and wild rabbits, and recently a new lagovirus was identified in Australia...
  3. Velarde R, Cavadini P, Neimanis A, Cabezón O, Chiari M, Gaffuri A, et al. Spillover Events of Infection of Brown Hares (Lepus europaeus) with Rabbit Haemorrhagic Disease Type 2 Virus (RHDV2) Caused Sporadic Cases of an European Brown Hare Syndrome-Like Disease in Italy and Spain. Transbound Emerg Dis. 2017;64:1750-1761 pubmed publisher
    Rabbit haemorrhagic disease virus (RHDV) is a lagovirus that can cause fatal hepatitis (rabbit haemorrhagic disease, RHD) with mortality of 80-90% in farmed and wild rabbits...
  4. Mahar J, Hall R, Peacock D, Kovaliski J, Piper M, Mourant R, et al. Rabbit haemorrhagic disease virus 2 (GI.2) is replacing endemic strains of RHDV in the Australian landscape within 18 months of its arrival. J Virol. 2017;: pubmed publisher
    i>Rabbit haemorrhagic disease virus 2 (RHDV2; Lagovirus GI.2) is a pathogenic calicivirus that affects European rabbits (Oryctolagus cuniculus) and various hare (Lepus) species. GI...
  5. Rouco C, Abrantes J, Serronha A, Lopes A, Maio E, Magalhaes M, et al. Epidemiology of RHDV2 (Lagovirus europaeus/GI.2) in free-living wild European rabbits in Portugal. Transbound Emerg Dis. 2017;: pubmed publisher
    ..the first outbreak of a novel aetiological agent of rabbit haemorrhagic disease commonly called RHDV2 or RHDVb (Lagovirus europaeus/GI.2, henceforth GI...
  6. Lopes A, Gavier Widen D, Le Gall Reculé G, Esteves P, Abrantes J. Complete coding sequences of European brown hare syndrome virus (EBHSV) strains isolated in 1982 in Sweden. Arch Virol. 2013;158:2193-6 pubmed publisher
    ..hare syndrome virus (EBHSV) and the closely related rabbit haemorrhagic disease virus (RHDV) comprise the genus Lagovirus, family Caliciviridae...
  7. Le Gall Reculé G, Zwingelstein F, Laurent S, Portejoie Y, Rasschaert D. Molecular epidemiology of European brown hare syndrome virus in France between 1989 and 2003. Arch Virol. 2006;151:1713-21 pubmed
    ..Our results demonstrate strong differences in genetic evolution between EBHSV and rabbit haemorrhagic disease virus, with persistence of the earlier EBHS viruses and interaction between the geographical and temporal distributions. ..
  8. Le Gall Reculé G, Lemaitre E, Bertagnoli S, Hubert C, Top S, Decors A, et al. Large-scale lagovirus disease outbreaks in European brown hares (Lepus europaeus) in France caused by RHDV2 strains spatially shared with rabbits (Oryctolagus cuniculus). Vet Res. 2017;48:70 pubmed publisher
    Rabbit haemorrhagic disease virus (RHDV) is a lagovirus that causes rabbit haemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus). In 2010, a new genotype called RHDV2 emerged in France...
  9. Frölich K, Kujawski O, Rudolph M, Ronsholt L, Speck S. European brown hare syndrome virus in free-ranging European brown hares from Argentina. J Wildl Dis. 2003;39:121-4 pubmed
    ..However, EBHS has not been reported to cause abnormal mortality in these hares. This is the first report of antibodies to EBHSV, EBHSV-antigen, and electron microscopy findings in free-ranging European brown hares from South America...
  10. Liu J, Kerr P, Wright J, Strive T. Serological assays to discriminate rabbit haemorrhagic disease virus from Australian non-pathogenic rabbit calicivirus. Vet Microbiol. 2012;157:345-54 pubmed publisher
    ..When used in parallel with RHDV serology, they could be used to monitor the dynamics of these two closely related but pathogenically distinct viruses in wild and domestic rabbit populations...
  11. Hoehn M, Kerr P, Strive T. In situ hybridisation assay for localisation of rabbit calicivirus Australia-1 (RCV-A1) in European rabbit (Oryctolagus cuniculus) tissues. J Virol Methods. 2013;188:148-52 pubmed publisher
    Recently, a new lagovirus enzootic in Australian wild rabbits was identified and described as rabbit calicivirus Australia-1 (RCV-A1)...
  12. Iacovakis C, Mamuris Z, Moutou K, Touloudi A, Hammer A, Valiakos G, et al. Polarisation of major histocompatibility complex II host genotype with pathogenesis of European Brown Hare syndrome virus. PLoS ONE. 2013;8:e74360 pubmed publisher
    ..000006 and P = 0.027). These data reveal a polarisation between EBHSV pathogenesis and MHC class II genotype within the European brown hare in Denmark. ..
  13. Jahnke M, Holmes E, Kerr P, Wright J, Strive T. Evolution and phylogeography of the nonpathogenic calicivirus RCV-A1 in wild rabbits in Australia. J Virol. 2010;84:12397-404 pubmed publisher
    ..RCV-A1 strains therefore exhibit strong phylogeographic separation and may constitute a useful tool to study recent host population dynamics and migration patterns, which in turn could be used to monitor rabbit control in Australia. ..
  14. Le Pendu J, Abrantes J, Bertagnoli S, Guitton J, Le Gall Reculé G, Lopes A, et al. Proposal for a unified classification system and nomenclature of lagoviruses. J Gen Virol. 2017;98:1658-1666 pubmed publisher
    ..amongst circulating viruses, there is a clear need to establish precise guidelines for classifying and naming lagovirus strains. Therefore, here we propose a new nomenclature based on phylogenetic relationships...
  15. Syrjälä P, Nylund M, Heinikainen S. European brown hare syndrome in free-living mountain hares (Lepus timidus) and European brown hares (Lepus europaeus) in Finland 1990-2002. J Wildl Dis. 2005;41:42-7 pubmed
    ..This is the first report of an outbreak of EBHS occurring mainly among free-living mountain hares from Finland. ..