rift valley fever virus


Summary: A mosquito-borne species of the PHLEBOVIRUS genus found in eastern, central, and southern Africa, producing massive hepatitis, abortion, and death in sheep, goats, cattle, and other animals. It also has caused disease in humans.

Top Publications

  1. Rostal M, Evans A, Sang R, Gikundi S, Wakhule L, Munyua P, et al. Identification of potential vectors of and detection of antibodies against Rift Valley fever virus in livestock during interepizootic periods. Am J Vet Res. 2010;71:522-6 pubmed publisher
    To evaluate the prevalence of Rift Valley fever virus (RVFV) antibodies in livestock and presence of competent mosquito vectors of RVFV during an interepizootic period (IEP) in Kenya.
  2. Ikegami T, Peters C, Makino S. Rift valley fever virus nonstructural protein NSs promotes viral RNA replication and transcription in a minigenome system. J Virol. 2005;79:5606-15 pubmed
    b>Rift Valley fever virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, has a tripartite negative-strand genome (S, M, and L segments) and is an important mosquito-borne pathogen for domestic animals and humans...
  3. Zaki A, Coudrier D, Yousef A, Fakeeh M, Bouloy M, Billecocq A. Production of monoclonal antibodies against Rift Valley fever virus Application for rapid diagnosis tests (virus detection and ELISA) in human sera. J Virol Methods. 2006;131:34-40 pubmed
  4. Tourre Y, Lacaux J, Vignolles C, Ndione J, Lafaye M. Mapping of zones potentially occupied by Aedes vexans and Culex poicilipes mosquitoes, the main vectors of Rift Valley fever in Senegal. Geospat Health. 2008;3:69-79 pubmed
    ..The results show the importance of pin-pointing small ponds (sizes down to 0.1 ha) and their geographical distribution in order to assess animal exposure to the RVF vectors. ..
  5. Kalveram B, Lihoradova O, Ikegami T. NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62. J Virol. 2011;85:6234-43 pubmed publisher
    b>Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus) is an important emerging pathogen of humans and ruminants...
  6. Cêtre Sossah C, Pédarrieu A, Guis H, Defernez C, Bouloy M, Favre J, et al. Prevalence of Rift Valley Fever among ruminants, Mayotte. Emerg Infect Dis. 2012;18:972-5 pubmed publisher
    ..a human case was confirmed in Comoros in 2007, 4 serosurveys among ruminants in Mayotte suggested that Rift Valley fever virus had been circulating at low levels since 2004, although no clinical cases occurred in animals...
  7. Xu W, Watts D, Costanzo M, Tang X, Venegas L, Jiao F, et al. The nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses. PLoS ONE. 2013;8:e59210 pubmed publisher
    There is no licensed human vaccine currently available for Rift Valley Fever Virus (RVFV), a Category A high priority pathogen and a serious zoonotic threat...
  8. Jeanmaire E, Rabenarivahiny R, Biarmann M, Rabibisoa L, Ravaomanana F, Randriamparany T, et al. Prevalence of Rift Valley fever infection in ruminants in Madagascar after the 2008 outbreak. Vector Borne Zoonotic Dis. 2011;11:395-402 pubmed publisher
    ..The data also suggest that the southern and northwestern areas may be endemic for RVFV, and that the virus may spread when ecological conditions are favorable for its amplification...
  9. Soumare B, Tempia S, Cagnolati V, Mohamoud A, Van Huylenbroeck G, Berkvens D. Screening for Rift Valley fever infection in northern Somalia: a GIS based survey method to overcome the lack of sampling frame. Vet Microbiol. 2007;121:249-56 pubmed
    ..In addition conditions favourable to the breeding and survival of the vector population and the high density of livestock make the Nugal Valley an area of high risk for a RVF outbreak where sentinel herds will be placed. ..

More Information

Publications180 found, 100 shown here

  1. Ba Y, Sall A, Diallo D, Mondo M, Girault L, Dia I, et al. Re-emergence of Rift Valley fever virus in Barkedji (Senegal, West Africa) in 2002-2003: identification of new vectors and epidemiological implications. J Am Mosq Control Assoc. 2012;28:170-8 pubmed
    The Rift Valley fever virus (RVFV) is a threat that must not be neglected, as the consequences of RVFV are dramatic, both for human and animal health...
  2. Abu Elyazeed R, el Sharkawy S, Olson J, Botros B, Soliman A, Salib A, et al. Prevalence of anti-Rift-Valley-fever IgM antibody in abattoir workers in the Nile delta during the 1993 outbreak in Egypt. Bull World Health Organ. 1996;74:155-8 pubmed
    ..24)) and handling animal parts (RR = 2.37). The findings suggest that abattoir workers represent a useful sentinel population for surveillance of RVF...
  3. Gauliard N, Billecocq A, Flick R, Bouloy M. Rift Valley fever virus noncoding regions of L, M and S segments regulate RNA synthesis. Virology. 2006;351:170-9 pubmed
    b>Rift Valley fever virus (RVFV) (Phlebovirus, Bunyaviridae) possesses a genome composed of three negative-stranded RNA molecules...
  4. Youssef B, Donia H. The potential role of rattus rattus in enzootic cycle of Rift Valley Fever in Egypt 2-application of reverse transcriptase polymerase chain reaction (RT-PCR) in blood samples of Rattus rattus. J Egypt Public Health Assoc. 2002;77:133-41 pubmed
    A reverse transcriptase -polymerase chain reaction (RT-PCR) was applied to detect Rift Valley Fever Virus (RVF-V) in blood samples of Rattus rattus (R...
  5. Ellenbecker M, Sears L, Li P, Lanchy J, Lodmell J. Characterization of RNA aptamers directed against the nucleocapsid protein of Rift Valley fever virus. Antiviral Res. 2012;93:330-9 pubmed publisher
    ..Finally, the aptamer RNAs were used to construct a sensitive fluorescence based sensor of N binding with potential applications for drug screening and imaging methodologies...
  6. Garcia S, Crance J, Billecocq A, Peinnequin A, Jouan A, Bouloy M, et al. Quantitative real-time PCR detection of Rift Valley fever virus and its application to evaluation of antiviral compounds. J Clin Microbiol. 2001;39:4456-61 pubmed
    The Rift Valley fever virus (RVFV), a member of the genus Phlebovirus (family Bunyaviridae) is an enveloped negative-strand RNA virus with a tripartite genome...
  7. Yamar B, Diallo D, Kebe C, Dia I, Diallo M. Aspects of bioecology of two Rift Valley Fever Virus vectors in Senegal (West Africa): Aedes vexans and Culex poicilipes (Diptera: Culicidae). J Med Entomol. 2005;42:739-50 pubmed
    The dispersal, population dynamics, and age structure of two Rift Valley Fever Virus (Phlebovirus: Bunyaviridae) (RVFV) vectors, Aedes vexans Meigen and Culex poicilipes Theobald, were investigated in northern Senegal...
  8. Gorchakov R, Volkova E, Yun N, Petrakova O, Linde N, Paessler S, et al. Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins. Virology. 2007;366:212-25 pubmed
    ..of Sindbis (SINV) and Venezuelan equine encephalitis (VEEV) viruses for their ability to express the Rift Valley fever virus (RVFV) envelope glycoprotein Gn and induce a protective immune response against RVFV infection...
  9. Adam I, Karsany M. Case report: Rift Valley Fever with vertical transmission in a pregnant Sudanese woman. J Med Virol. 2008;80:929 pubmed publisher
    ..She delivered baby of 3.2 kg with skin rash, palpable liver and spleen. The two samples from the mother and neonate were found to be positive for RVF-IgM. This report demonstrate that, RVF can be vertically transmitted. ..
  10. Lara E, Billecocq A, Léger P, Bouloy M. Characterization of wild-type and alternate transcription termination signals in the Rift Valley fever virus genome. J Virol. 2011;85:12134-45 pubmed publisher
    ..Our data also showed that the signal tolerated some sequence variations, since mutation into 5'-GCAGC-3' was functional, and 5'-GUAGC-3' is likely the signal for the termination of the 3' end of the L mRNA. ..
  11. Sang R, Kioko E, Lutomiah J, Warigia M, Ochieng C, O Guinn M, et al. Rift Valley fever virus epidemic in Kenya, 2006/2007: the entomologic investigations. Am J Trop Med Hyg. 2010;83:28-37 pubmed publisher
  12. Mpeshe S, Haario H, Tchuenche J. A mathematical model of Rift Valley Fever with human host. Acta Biotheor. 2011;59:231-50 pubmed publisher
    ..Numerical simulations support the analytical results in further exploring theoretically the long-term dynamics of the disease at the population level. ..
  13. Nicolas G, Durand B, Duboz R, Rakotondravao R, Chevalier V. Description and analysis of the cattle trade network in the Madagascar highlands: potential role in the diffusion of Rift Valley fever virus. Acta Trop. 2013;126:19-27 pubmed publisher
    ..The negative association of the distance to the nearest water point suggests that after RVFV introduction, a substantial part of transmission may be due to vectors...
  14. Harmsen M, Antonis A, Moormann R, Kortekaas J. Parenteral vaccination of mammalian livestock with Newcastle disease virus-based vector vaccines offers optimal efficacy and safety. Bioeng Bugs. 2011;2:58-62 pubmed publisher
    ..We recently showed that intramuscular vaccination with NDV-based Rift Valley fever virus (RVFV) vaccines provides complete protection in mice and induces neutralizing antibodies in sheep and ..
  15. Baer A, Austin D, Narayanan A, Popova T, Kainulainen M, Bailey C, et al. Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication. J Biol Chem. 2012;287:7399-410 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a highly pathogenic arthropod-borne virus infecting a wide range of vertebrate hosts. Of particular interest is the nonstructural NSs protein, which forms large filamentous fibril bundles in the nucleus...
  16. Al Afaleq A, Hussein M, Al Naeem A, Housawi F, Kabati A. Seroepidemiological study of Rift Valley fever (RVF) in animals in Saudi Arabia. Trop Anim Health Prod. 2012;44:1535-9 pubmed publisher
    ..The need for regular monitoring of animals both within the outbreak zone of 2000 and other parts of the kingdom is strongly emphasized. ..
  17. Grobbelaar A, Weyer J, Leman P, Kemp A, Paweska J, Swanepoel R. Molecular epidemiology of Rift Valley fever virus. Emerg Infect Dis. 2011;17:2270-6 pubmed publisher
    Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010)...
  18. Jansen van Vuren P, Potgieter A, Paweska J, van Dijk A. Preparation and evaluation of a recombinant Rift Valley fever virus N protein for the detection of IgG and IgM antibodies in humans and animals by indirect ELISA. J Virol Methods. 2007;140:106-14 pubmed
    This paper describes the cloning, sequencing and bacterial expression of the N protein of the Rift Valley fever virus (RVFV) ZIM688/78 isolate and its evaluation in indirect ELISAs (I-ELISA) for the detection of IgM and IgG antibodies in ..
  19. Bird B, Khristova M, Rollin P, Ksiazek T, Nichol S. Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry. J Virol. 2007;81:2805-16 pubmed
    ..In addition to insights into the evolution and ecology of RVF virus, these genomic data also provide a foundation for the design of molecular detection assays and prototype vaccines useful in combating this important disease. ..
  20. Won S, Ikegami T, Peters C, Makino S. NSm protein of Rift Valley fever virus suppresses virus-induced apoptosis. J Virol. 2007;81:13335-45 pubmed
    b>Rift Valley fever virus (RVFV) is a member of the genus Phlebovirus within the family Bunyaviridae. It can cause severe epidemics among ruminants and fever, myalgia, a hemorrhagic syndrome, and/or encephalitis in humans...
  21. Narayanan A, Kehn Hall K, Senina S, Lundberg L, Van Duyne R, Guendel I, et al. Curcumin inhibits Rift Valley fever virus replication in human cells. J Biol Chem. 2012;287:33198-214 pubmed
    b>Rift Valley fever virus (RVFV) is an arbovirus that is classified as a select agent, an emerging infectious virus, and an agricultural pathogen. Understanding RVFV-host interactions is imperative to the design of novel therapeutics...
  22. Hartman A, Powell D, Bethel L, Caroline A, Schmid R, Oury T, et al. Aerosolized rift valley fever virus causes fatal encephalitis in african green monkeys and common marmosets. J Virol. 2014;88:2235-45 pubmed publisher
    ..Both AGM and marmosets would serve as useful models of aerosol infection with RVFV. ..
  23. Euler M, Wang Y, Nentwich O, Piepenburg O, Hufert F, Weidmann M. Recombinase polymerase amplification assay for rapid detection of Rift Valley fever virus. J Clin Virol. 2012;54:308-12 pubmed publisher
    Detection of nucleic acids of Rift Valley fever virus (RVFV) has been shown to be useful in field diagnostics. To develop an isothermal 'recombinase polymerase amplification (RPA)' assay on an ESEquant tubescanner device...
  24. Mudhasani R, Tran J, Retterer C, Radoshitzky S, Kota K, Altamura L, et al. IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus. J Virol. 2013;87:8451-64 pubmed publisher
    ..a broad spectrum of antiviral activity against several members of the Bunyaviridae family, including Rift Valley fever virus (RVFV), La Crosse virus, Andes virus, and Hantaan virus, all of which can cause severe disease in humans ..
  25. Ikegami T, Won S, Peters C, Makino S. Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene. J Virol. 2006;80:2933-40 pubmed
    b>Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negative-strand genome, causes a mosquito-borne disease that is endemic in sub-Saharan African countries and that also causes large epidemics among ..
  26. Habjan M, Penski N, Wagner V, Spiegel M, Overby A, Kochs G, et al. Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses. Virology. 2009;385:400-8 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a highly pathogenic member of the family Bunyaviridae that needs to be handled under biosafety level (BSL) 3 conditions...
  27. Mandell R, Flick R. Rift Valley fever virus: an unrecognized emerging threat?. Hum Vaccin. 2010;6:597-601 pubmed
    b>Rift Valley fever virus (RVFV) is an arthropod-borne pathogen that often results in severe morbidity and mortality in both humans and livestock...
  28. Crabtree M, Kent Crockett R, Bird B, Nichol S, Erickson B, Biggerstaff B, et al. Infection and transmission of Rift Valley fever viruses lacking the NSs and/or NSm genes in mosquitoes: potential role for NSm in mosquito infection. PLoS Negl Trop Dis. 2012;6:e1639 pubmed publisher
    b>Rift Valley fever virus is an arthropod-borne human and animal pathogen responsible for large outbreaks of acute and febrile illness throughout Africa and the Arabian Peninsula...
  29. de Boer S, Kortekaas J, de Haan C, Rottier P, Moormann R, Bosch B. Heparan sulfate facilitates Rift Valley fever virus entry into the cell. J Virol. 2012;86:13767-71 pubmed publisher
    b>Rift Valley fever virus (RVFV), an emerging arthropod-borne pathogen, has a broad host and cell tropism...
  30. Métras R, Baguelin M, Edmunds W, Thompson P, Kemp A, Pfeiffer D, et al. Transmission potential of Rift Valley fever virus over the course of the 2010 epidemic in South Africa. Emerg Infect Dis. 2013;19:916-24 pubmed publisher
    ..Increased availability of vaccine use data would enable evaluation of the effect of RVF vaccination campaigns. ..
  31. Drosten C, Göttig S, Schilling S, Asper M, Panning M, Schmitz H, et al. Rapid detection and quantification of RNA of Ebola and Marburg viruses, Lassa virus, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-PCR. J Clin Microbiol. 2002;40:2323-30 pubmed
    ..Ebola and Marburg viruses (MBGV/EBOV), Lassa virus (LASV), Crimean-Congo hemorrhagic fever virus (CCHFV), Rift Valley fever virus (RVFV), dengue virus (DENV), and yellow fever virus (YFV)...
  32. Njenga M, Paweska J, Wanjala R, Rao C, Weiner M, Omballa V, et al. Using a field quantitative real-time PCR test to rapidly identify highly viremic rift valley fever cases. J Clin Microbiol. 2009;47:1166-71 pubmed publisher
    ..This study shows a correlation between high viremia and fatality and indicates that qRT-PCR testing can identify nearly all fatal RVF cases...
  33. Paweska J, Burt F, Swanepoel R. Validation of IgG-sandwich and IgM-capture ELISA for the detection of antibody to Rift Valley fever virus in humans. J Virol Methods. 2005;124:173-81 pubmed
  34. Wallace D, Ellis C, Espach A, Smith S, Greyling R, Viljoen G. Protective immune responses induced by different recombinant vaccine regimes to Rift Valley fever. Vaccine. 2006;24:7181-9 pubmed
    The glycoprotein (GP) and nucleocapsid (NC) genes of Rift Valley fever virus (RVFV) were expressed in different expression systems and were evaluated for their ability to protect mice from virulent challenge using a prime-boost regime...
  35. Nderitu L, Lee J, Omolo J, Omulo S, O Guinn M, Hightower A, et al. Sequential Rift Valley fever outbreaks in eastern Africa caused by multiple lineages of the virus. J Infect Dis. 2011;203:655-65 pubmed publisher
    ..The findings indicate that the sequential RVF epidemics in the region were caused by multiple lineages of the RVF virus, sometimes independently activated or introduced in distinct outbreak foci. ..
  36. Filone C, Heise M, Doms R, Bertolotti Ciarlet A. Development and characterization of a Rift Valley fever virus cell-cell fusion assay using alphavirus replicon vectors. Virology. 2006;356:155-64 pubmed
    b>Rift Valley fever virus (RVFV), a member of the Phlebovirus genus in the Bunyaviridae family, is transmitted by mosquitoes and infects both humans and domestic animals, particularly cattle and sheep...
  37. Martín Folgar R, Lorenzo G, Boshra H, Iglesias J, Mateos F, Borrego B, et al. Development and characterization of monoclonal antibodies against Rift Valley fever virus nucleocapsid protein generated by DNA immunization. MAbs. 2010;2:275-84 pubmed
    ..describes the generation of monoclonal antibodies directed to immunogenic nucleoprotein N epitopes of Rift Valley fever virus (RVFV), and their application in diagnostics, both for antibody detection in competitive ELISA and for ..
  38. Turell M, Wilson W, Bennett K. Potential for North American mosquitoes (Diptera: Culicidae) to transmit rift valley fever virus. J Med Entomol. 2010;47:884-9 pubmed
    To determine which arthropods should be targeted for control should Rift Valley fever virus (RVFV) be detected in North America, we evaluated Culex erraticus (Dyar and Knab), Culex erythrothorax Dyar, Culex nigripalpus Theobald, Culex ..
  39. Krida G, Diancourt L, Bouattour A, Rhim A, Chermiti B, Failloux A. [Assessment of the risk of introduction to Tunisia of the Rift Valley fever virus by the mosquito Culex pipiens]. Bull Soc Pathol Exot. 2011;104:250-9 pubmed publisher
    ..However, as RVF is an emerging disease transmitted by several other potential mosquito species (e.g. Ochlerotatus caspius), attention should be maintained to survey livestock and mosquitoes in Tunisia. ..
  40. Boshra H, Lorenzo G, Rodriguez F, Brun A. A DNA vaccine encoding ubiquitinated Rift Valley fever virus nucleoprotein provides consistent immunity and protects IFNAR(-/-) mice upon lethal virus challenge. Vaccine. 2011;29:4469-75 pubmed publisher
    Current vaccine candidates against Rift Valley fever virus (RVFV) incorporate the viral structural glycoproteins as antigens, since triggering antibody responses against them usually correlates with protection...
  41. Kortekaas J, Oreshkova N, Cobos Jiménez V, Vloet R, Potgieter C, Moormann R. Creation of a nonspreading Rift Valley fever virus. J Virol. 2011;85:12622-30 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic bunyavirus of the genus Phlebovirus and a serious human and veterinary pathogen...
  42. Soti V, Chevalier V, Maura J, Begue A, Lelong C, Lancelot R, et al. Identifying landscape features associated with Rift Valley fever virus transmission, Ferlo region, Senegal, using very high spatial resolution satellite imagery. Int J Health Geogr. 2013;12:10 pubmed publisher
    ..Our results highlight the potential of very high spatial resolution remote sensing data for identifying environmental risk factors and mapping RVF risk areas at a local scale. ..
  43. Pourrut X, Nkoghe D, Souris M, Paupy C, Paweska J, Padilla C, et al. Rift Valley fever virus seroprevalence in human rural populations of Gabon. PLoS Negl Trop Dis. 2010;4:e763 pubmed publisher
    ..RVFV-specific IgG was found in a total of 145 individuals (3.3%) suggesting the wide circulation of Rift Valley fever virus in Gabon...
  44. Amraoui F, Krida G, Bouattour A, Rhim A, Daaboub J, Harrat Z, et al. Culex pipiens, an experimental efficient vector of West Nile and Rift Valley fever viruses in the Maghreb region. PLoS ONE. 2012;7:e36757 pubmed publisher
    ..b>Rift Valley fever virus (RVFV) re-emerges periodically in Africa causing massive outbreaks...
  45. Paweska J, Jansen van Vuren P, Swanepoel R. Validation of an indirect ELISA based on a recombinant nucleocapsid protein of Rift Valley fever virus for the detection of IgG antibody in humans. J Virol Methods. 2007;146:119-24 pubmed
    An indirect enzyme-linked immunoassay (I-ELISA) based on the recombinant nucleocapsid protein (rNp) of Rift Valley fever virus was validated for the detection of specific IgG antibody in human sera...
  46. Crabtree M, Sang R, Lutomiah J, Richardson J, Miller B. Arbovirus surveillance of mosquitoes collected at sites of active Rift Valley fever virus transmission: Kenya, 2006-2007. J Med Entomol. 2009;46:961-4 pubmed
    ..Twenty-seven virus isolations were made comprising seven viruses from three arbovirus families...
  47. Ikegami T, Makino S. Rift valley fever vaccines. Vaccine. 2009;27 Suppl 4:D69-72 pubmed publisher
    b>Rift Valley fever virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, is a negative-stranded RNA virus carrying a tripartite RNA genome...
  48. Soi R, Rurangirwa F, McGuire T, Rwambo P, Demartini J, Crawford T. Protection of sheep against Rift Valley fever virus and sheep poxvirus with a recombinant capripoxvirus vaccine. Clin Vaccine Immunol. 2010;17:1842-9 pubmed publisher
    ..A capripoxvirus (CPV) recombinant virus (rKS1/RVFV) was developed, which expressed the Rift Valley fever virus (RVFV) Gn and Gc glycoproteins...
  49. Murakami S, Terasaki K, Narayanan K, Makino S. Roles of the coding and noncoding regions of rift valley Fever virus RNA genome segments in viral RNA packaging. J Virol. 2012;86:4034-9 pubmed publisher
    We characterized the RNA elements involved in the packaging of Rift Valley fever virus RNA genome segments, L, M, and S...
  50. Thonnon J, Picquet M, Thiongane Y, Lo M, Sylla R, Vercruysse J. Rift valley fever surveillance in the lower Senegal river basin: update 10 years after the epidemic. Trop Med Int Health. 1999;4:580-5 pubmed
    ..A general analysis of the risk of re-emergence and the efficiency of this RVF surveillance system are presented. ..
  51. Chevalier V, Lancelot R, Thiongane Y, Sall B, Diaité A, Mondet B. Rift Valley fever in small ruminants, Senegal, 2003. Emerg Infect Dis. 2005;11:1693-700 pubmed
    ..Rift Valley fever surveillance should be improved to allow early detection of virus activity. Ruminant vaccination programs should be prepared to confront the foreseeable higher risks for future epidemics of this disease. ..
  52. Kading R, Crabtree M, Miller B. Inactivation of infectious virus and serological detection of virus antigen in Rift Valley fever virus-exposed mosquitoes fixed with paraformaldehyde. J Virol Methods. 2013;189:184-8 pubmed publisher
    ..regulatory importance for research involving viruses that are classified as select agents such as Rift Valley fever virus (RVFV)...
  53. Lorenzo G, Martín Folgar R, Hevia E, Boshra H, Brun A. Protection against lethal Rift Valley fever virus (RVFV) infection in transgenic IFNAR(-/-) mice induced by different DNA vaccination regimens. Vaccine. 2010;28:2937-44 pubmed publisher
    ..Interestingly, the combination of both vaccine constructs induced specific lymphoblast proliferation upon stimulation with a recombinant nucleoprotein...
  54. Scott T, Paweska J, Arbuthnot P, Weinberg M. Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs. Antivir Ther. 2012;17:643-56 pubmed publisher
    b>Rift Valley fever virus (RVFV), a member of the Bunyaviridae family, may cause severe hepatitis, encephalitis and haemorrhagic fever in humans...
  55. Nfon C, Marszal P, Zhang S, Weingartl H. Innate immune response to Rift Valley fever virus in goats. PLoS Negl Trop Dis. 2012;6:e1623 pubmed publisher
    ..These differences need to be considered when testing RVF vaccines in laboratory settings. ..
  56. Xu F, Liu D, Nunes M, Da Rosa A, Tesh R, Xiao S. Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus Phlebovirus (Bunyaviridae). Am J Trop Med Hyg. 2007;76:1194-200 pubmed
    ..two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans...
  57. de Boer S, Kortekaas J, Antonis A, Kant J, van Oploo J, Rottier P, et al. Rift Valley fever virus subunit vaccines confer complete protection against a lethal virus challenge. Vaccine. 2010;28:2330-9 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an emerging mosquito-borne virus causing significant morbidity and mortality in livestock and humans. Rift Valley fever is endemic in Africa, but also outside this continent outbreaks have been reported...
  58. El Mamy A, Baba M, Barry Y, Isselmou K, Dia M, El Kory M, et al. Unexpected Rift Valley fever outbreak, northern Mauritania. Emerg Infect Dis. 2011;17:1894-6 pubmed publisher
    ..Camels probably played a central role in the local amplification of the virus. We describe the main clinical signs (hemorrhagic fever, icterus, and nervous symptoms) observed during the outbreak. ..
  59. Olive M, Goodman S, Reynes J. The role of wild mammals in the maintenance of Rift Valley fever virus. J Wildl Dis. 2012;48:241-66 pubmed
    b>Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting primarily domestic ruminants and humans. Numerous vector species are known or implicated in the transmission of RVFV...
  60. Paweska J, Burt F, Anthony F, Smith S, Grobbelaar A, Croft J, et al. IgG-sandwich and IgM-capture enzyme-linked immunosorbent assay for the detection of antibody to Rift Valley fever virus in domestic ruminants. J Virol Methods. 2003;113:103-12 pubmed
    ..sandwich and capture ELISAs (both based on inactivated antigen) for detection of IgG and IgM antibody to Rift Valley fever virus in bovine, caprine and ovine sera...
  61. Morrill J, Ikegami T, Yoshikawa Iwata N, Lokugamage N, Won S, Terasaki K, et al. Rapid accumulation of virulent rift valley Fever virus in mice from an attenuated virus carrying a single nucleotide substitution in the m RNA. PLoS ONE. 2010;5:e9986 pubmed publisher
    b>Rift Valley fever virus (RVFV), a member of the genus Phlebovirus within the family Bunyaviridae, is a negative-stranded RNA virus with a tripartite genome...
  62. Moutailler S, Roche B, Thiberge J, Caro V, Rougeon F, Failloux A. Host alternation is necessary to maintain the genome stability of rift valley fever virus. PLoS Negl Trop Dis. 2011;5:e1156 pubmed publisher
    ..To test this hypothesis, we used Rift Valley fever virus (RVFV), an arbovirus that can be transmitted either directly (between vertebrates during the manipulation ..
  63. Austin D, Baer A, Lundberg L, Shafagati N, Schoonmaker A, Narayanan A, et al. p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production. PLoS ONE. 2012;7:e36327 pubmed publisher
    b>Rift Valley fever virus (RVFV) is an emerging viral zoonosis that is responsible for devastating outbreaks among livestock and is capable of causing potentially fatal disease in humans...
  64. Engdahl C, Näslund J, Lindgren L, Ahlm C, Bucht G. The Rift Valley Fever virus protein NSm and putative cellular protein interactions. Virol J. 2012;9:139 pubmed publisher
    ..We have identified nine murine proteins that interact with NSm protein of Rift Valley Fever virus, and the putative protein-protein interactions were confirmed by growth selection procedures and ?-gal ..
  65. Abdo Salem S, Gerbier G, Bonnet P, Al Qadasi M, Tran A, Thiry E, et al. Descriptive and spatial epidemiology of Rift valley fever outbreak in Yemen 2000-2001. Ann N Y Acad Sci. 2006;1081:240-2 pubmed
    ..The spatial distribution of outbreaks was then studied at two scales: at the national level and at a local scale in the particular area of Wadi Mawr in the Tihama plain, Western coast of Yemen. ..
  66. . Rift Valley fever outbreak--Kenya, November 2006-January 2007. MMWR Morb Mortal Wkly Rep. 2007;56:73-6 pubmed
  67. LaBeaud A, Ochiai Y, Peters C, Muchiri E, King C. Spectrum of Rift Valley fever virus transmission in Kenya: insights from three distinct regions. Am J Trop Med Hyg. 2007;76:795-800 pubmed
    b>Rift Valley fever virus (RVFV) is an emerging pathogen that maintains high biodefense priority based on its threat to livestock, its ability to cause human hemorrhagic fever, and its potential for aerosol spread...
  68. Kasari T, Carr D, Lynn T, Weaver J. Evaluation of pathways for release of Rift Valley fever virus into domestic ruminant livestock, ruminant wildlife, and human populations in the continental United States. J Am Vet Med Assoc. 2008;232:514-29 pubmed publisher
    To evaluate the feasibility for Rift Valley fever virus (RVFV) to enter the continental United States by various routes as well as to identify states in which domestic and wild ruminant and human populations would be most vulnerable to ..
  69. Ikegami T, Narayanan K, Won S, Kamitani W, Peters C, Makino S. Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation. PLoS Pathog. 2009;5:e1000287 pubmed publisher
    b>Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) is a negative-stranded RNA virus with a tripartite genome...
  70. Elfadil A, Hasab Allah K, Dafa Allah O. Factors associated with rift valley fever in south-west Saudi Arabia. Rev Sci Tech. 2006;25:1137-45 pubmed
  71. Näslund J, Lagerqvist N, Lundkvist A, Evander M, Ahlm C, Bucht G. Kinetics of Rift Valley Fever Virus in experimentally infected mice using quantitative real-time RT-PCR. J Virol Methods. 2008;151:277-82 pubmed publisher
    ..The RVFV quantitative RT-PCR proved to be a valuable diagnostic tool during the first days of infection, before detectable antibody levels and visual symptoms of RVF were observed. ..
  72. Bouloy M, Janzen C, Vialat P, Khun H, Pavlovic J, Huerre M, et al. Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSs. J Virol. 2001;75:1371-7 pubmed
    b>Rift Valley fever virus (RVFV), a phlebovirus of the family Bunyaviridae, is a major public health threat in Egypt and sub-Saharan Africa...
  73. Hunter P, Erasmus B, Vorster J. Teratogenicity of a mutagenised Rift Valley fever virus (MVP 12) in sheep. Onderstepoort J Vet Res. 2002;69:95-8 pubmed
    A 5-fluorouracil mutagenised Rift Valley fever virus strain, which was shown to be attenuated and immunogenic in cattle and sheep, was evaluated for its ability to cause teratogenic effects in pregnant sheep...
  74. Freiberg A, Sherman M, Morais M, Holbrook M, Watowich S. Three-dimensional organization of Rift Valley fever virus revealed by cryoelectron tomography. J Virol. 2008;82:10341-8 pubmed publisher
    b>Rift Valley fever virus (RVFV) is a member of the Bunyaviridae virus family (genus Phlebovirus) and is considered to be one of the most important pathogens in Africa, causing viral zoonoses in livestock and humans...
  75. Seufi A, Galal F. Role of Culex and Anopheles mosquito species as potential vectors of rift valley fever virus in Sudan outbreak, 2007. BMC Infect Dis. 2010;10:65 pubmed publisher
    ..Case management related interventions; health education and vector control efforts are extremely effective in preparedness for viral hemorrhagic fever and other seasonal outbreaks. ..
  76. Chevalier V, Rakotondrafara T, Jourdan M, Heraud J, Andriamanivo H, Durand B, et al. An unexpected recurrent transmission of Rift Valley fever virus in cattle in a temperate and mountainous area of Madagascar. PLoS Negl Trop Dis. 2011;5:e1423 pubmed publisher
    ..The goal of the present study was to evaluate the point prevalence of antibodies against Rift Valley Fever Virus (RVFV) in cattle in the Anjozorobe district, located in the wet and temperate highland region of ..
  77. Bird B, Nichol S. Breaking the chain: Rift Valley fever virus control via livestock vaccination. Curr Opin Virol. 2012;2:315-23 pubmed publisher
    b>Rift Valley fever virus is a mosquito-borne pathogen of livestock and humans that causes widespread and devastating outbreaks of severe and often fatal disease throughout Africa and portions of the Arabian Peninsula...
  78. Moutailler S, Krida G, Schaffner F, Vazeille M, Failloux A. Potential vectors of Rift Valley fever virus in the Mediterranean region. Vector Borne Zoonotic Dis. 2008;8:749-53 pubmed publisher
    ..Aedes vexans, Anopheles gambiae, Culex pipiens, Culex quinquefasciatus) to disseminate two strains of Rift Valley fever virus (RVFV), the virulent ZH548 and the avirulent Clone 13. After feeding on an infectious blood meal at 10(8...
  79. Kamal S. Pathological studies on postvaccinal reactions of Rift Valley fever in goats. Virol J. 2009;6:94 pubmed publisher
    ..It could be concluded that the use of live attenuated vaccine of RVF (Smithburn strain) for immunization of live stock is not safe in Egypt as it considered an endemic area...
  80. Jansen van Vuren P, Tiemessen C, Paweska J. Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice. PLoS ONE. 2011;6:e25027 pubmed publisher
    The known virulence factor of Rift Valley fever virus (RVFV), the NSs protein, counteracts the antiviral effects of the type I interferon response...
  81. Fernandez J, Billecocq A, Durand J, Cêtre Sossah C, Cardinale E, Marianneau P, et al. The nonstructural protein NSs induces a variable antibody response in domestic ruminants naturally infected with Rift Valley fever virus. Clin Vaccine Immunol. 2012;19:5-10 pubmed publisher
    ..These results are discussed in light of differentiation between infected and vaccinated animals (DIVA) tests distinguishing naturally infected animals and those vaccinated with NSs-defective vaccines...
  82. Botros B, Omar A, Elian K, Mohamed G, Soliman A, Salib A, et al. Adverse response of non-indigenous cattle of European breeds to live attenuated Smithburn Rift Valley fever vaccine. J Med Virol. 2006;78:787-91 pubmed
    ..Virus isolation from the fetus suggests in utero transmission of used vaccine virus, which resulted in high abortions in European cows. ..
  83. Le Roux C, Kubo T, Grobbelaar A, van Vuren P, Weyer J, Nel L, et al. Development and evaluation of a real-time reverse transcription-loop-mediated isothermal amplification assay for rapid detection of Rift Valley fever virus in clinical specimens. J Clin Microbiol. 2009;47:645-51 pubmed publisher
    ..isothermal amplification assay (RT-LAMP) targeting the genomic large RNA segment of Rift Valley fever virus (RVFV)...
  84. Anyangu A, Gould L, Sharif S, Nguku P, Omolo J, Mutonga D, et al. Risk factors for severe Rift Valley fever infection in Kenya, 2007. Am J Trop Med Hyg. 2010;83:14-21 pubmed publisher
    ..67, 95% CI = 1.07-12.64, PAR% = 47%). Exposures related to animal contact were associated with acute RVF infection, whereas exposures to mosquitoes were not independent risk factors. ..
  85. Papin J, Verardi P, Jones L, Monge Navarro F, Brault A, Holbrook M, et al. Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice. Proc Natl Acad Sci U S A. 2011;108:14926-31 pubmed publisher
    ..RVF) is a zoonotic disease endemic in Africa and the Arabian Peninsula caused by the highly infectious Rift Valley fever virus (RVFV) that can be lethal to humans and animals and results in major losses in the livestock industry...
  86. Mwaengo D, Lorenzo G, Iglesias J, Warigia M, Sang R, Bishop R, et al. Detection and identification of Rift Valley fever virus in mosquito vectors by quantitative real-time PCR. Virus Res. 2012;169:137-43 pubmed publisher
    ..In this study, molecular detection of Rift Valley fever virus (RVFV) in mosquito samples from the 2006 to 2007 East African outbreaks was performed using quantitative ..
  87. Pepin M, Bouloy M, Bird B, Kemp A, Paweska J. Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Vet Res. 2010;41:61 pubmed
  88. Lokugamage N, Freiberg A, Morrill J, Ikegami T. Genetic subpopulations of Rift Valley fever virus strains ZH548 and MP-12 and recombinant MP-12 strains. J Virol. 2012;86:13566-75 pubmed publisher
    b>Rift Valley fever virus strain MP-12 was generated by serial plaque passages of parental strain ZH548 12 times in MRC-5 cells in the presence of a chemical mutagen, 5-fluorouracil...
  89. Won S, Ikegami T, Peters C, Makino S. NSm and 78-kilodalton proteins of Rift Valley fever virus are nonessential for viral replication in cell culture. J Virol. 2006;80:8274-8 pubmed
    ..A competition-propagation assay revealed that the parental virus was slightly more fit than the mutant virus lacking expression of both proteins. ..
  90. Kortekaas J, Dekker A, de Boer S, Weerdmeester K, Vloet R, de Wit A, et al. Intramuscular inoculation of calves with an experimental Newcastle disease virus-based vector vaccine elicits neutralizing antibodies against Rift Valley fever virus. Vaccine. 2010;28:2271-6 pubmed publisher
    ..In this study, we have constructed a recombinant NDV vaccine virus, named NDFL-Gn, that produces the Rift Valley fever virus (RVFV) Gn glycoprotein. Calves were immunized via either the intranasal route or the intramuscular route...