la crosse virus


Summary: A serotype of the species California encephalitis virus (ENCEPHALITIS VIRUS, CALIFORNIA), in the genus ORTHOBUNYAVIRUS, causing human MENINGOENCEPHALITIS. This is the agent most responsible for California encephalitis (ENCEPHALITIS, CALIFORNIA), the most prevalent mosquito-borne disease recognized in the United States.

Top Publications

  1. Barker C, Paulson S, Cantrell S, Davis B. Habitat preferences and phenology of Ochlerotatus triseriatus and Aedes albopictus (Diptera: Culicidae) in southwestern Virginia. J Med Entomol. 2003;40:403-10 pubmed
    Recently, the number of reported human cases of La Crosse encephalitis, an illness caused by mosquito-borne La Crosse virus (LAC), has increased in southwestern Virginia, resulting in a need for better understanding of the virus cycle ..
  2. Anderson J, Schneider J, Grimstad P, Severson D. Quantitative genetics of vector competence for La Crosse virus and body size in Ochlerotatus hendersoni and Ochlerotatus triseriatus interspecific hybrids. Genetics. 2005;169:1529-39 pubmed
    b>La Crosse virus is a leading cause of pediatric encephalitis in the United States. The mosquito Ochlerotatus triseriatus is an efficient vector for La Crosse virus, whereas the closely related O...
  3. Bennett R, Ton D, Hanson C, Murphy B, Whitehead S. Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes. Virol J. 2007;4:41 pubmed
    b>La Crosse virus (LACV), family Bunyaviridae, is a mosquito-borne virus recognized as a major cause of pediatric encephalitis in North America with 70-130 symptomatic cases each year...
  4. Bennett R, Cress C, Ward J, Firestone C, Murphy B, Whitehead S. La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys. Virol J. 2008;5:25 pubmed publisher
    b>La Crosse virus (LACV), family Bunyaviridae, was first identified as a human pathogen in 1960 after its isolation from a 4 year-old girl with fatal encephalitis in La Crosse, Wisconsin...
  5. Huang C, Thompson W, Campbell W. Comparison of the M RNA genome segments of two human isolates of La Crosse virus. Virus Res. 1995;36:177-85 pubmed
    ..The two viruses were identical in terms of predicted amino acid sequence in the region believed to represent a nonstructural protein. These data have been further compared to those available for two other California serogroup isolates...
  6. Szumlas D, Apperson C, Hartig P, Francy D, Karabatsos N. Seroepidemiology of La Crosse virus infection in humans in western North Carolina. Am J Trop Med Hyg. 1996;54:332-7 pubmed
    ..An additive increase in risk of 1.5 times over each age group was found, so that the oldest age group ( > or = 75 years) was 7.5 times more likely to have been exposed to LAC virus than was the youngest age group ( < 1-14 years)...
  7. McJunkin J, de los Reyes E, Irazuzta J, Caceres M, Khan R, Minnich L, et al. La Crosse encephalitis in children. N Engl J Med. 2001;344:801-7 pubmed
    ..La Crosse encephalitis is a mosquito-borne disease that can be mistaken for herpes simplex encephalitis. It has been reported in 28 states but may be underrecognized...
  8. Borucki M, Kempf B, Blitvich B, Blair C, Beaty B. La Crosse virus: replication in vertebrate and invertebrate hosts. Microbes Infect. 2002;4:341-50 pubmed
    b>La Crosse virus is maintained in a cycle involving mosquitoes and small mammals. Vertebrate cell infection is generally cytolytic; vector cell infection results in persistent infection...
  9. Blakqori G, Delhaye S, Habjan M, Blair C, S nchez Vargas I, Olson K, et al. La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. J Virol. 2007;81:4991-9 pubmed publisher
    b>La Crosse virus (LACV) is a mosquito-transmitted member of the Bunyaviridae family that causes severe encephalitis in children...

More Information

Publications101 found, 100 shown here

  1. Pekosz A, Griot C, Stillmock K, Nathanson N, Gonzalez Scarano F. Protection from La Crosse virus encephalitis with recombinant glycoproteins: role of neutralizing anti-G1 antibodies. J Virol. 1995;69:3475-81 pubmed
    b>La Crosse virus, a member of the California serogroup of bunyaviruses, is an important cause of pediatric encephalitis in the midwestern United States...
  2. Erwin P, Jones T, Gerhardt R, Halford S, Smith A, Patterson L, et al. La Crosse encephalitis in Eastern Tennessee: clinical, environmental, and entomological characteristics from a blinded cohort study. Am J Epidemiol. 2002;155:1060-5 pubmed
    A blinded cohort study was conducted in 2000 to better understand the emergence of La Crosse virus infection in eastern Tennessee, with special emphasis on the potential mosquito vector(s)...
  3. Utz J, Apperson C, MacCormack J, Salyers M, Dietz E, McPherson J. Economic and social impacts of La Crosse encephalitis in western North Carolina. Am J Trop Med Hyg. 2003;69:509-18 pubmed
    ..The socioeconomic burden resulting from LACE is substantial, which highlights the importance of the illness in western North Carolina, as well as the need for active surveillance, reporting, and prevention programs for the infection...
  4. Haddow A, Odoi A. The incidence risk, clustering, and clinical presentation of La Crosse virus infections in the eastern United States, 2003-2007. PLoS ONE. 2009;4:e6145 pubmed publisher
    Although La Crosse virus (LACV) is one of the most common causes of pediatric arboviral infections in the United States, little has been done to assess its geographic distribution, identify areas of higher risk of disease, and to provide ..
  5. Hefti H, Frese M, Landis H, Di Paolo C, Aguzzi A, Haller O, et al. Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol. 1999;73:6984-91 pubmed
    ..Here, we show that MxA confers resistance to Thogoto virus, La Crosse virus, and Semliki Forest virus...
  6. Wurtz R, Paleologos N. La Crosse encephalitis presenting like herpes simplex encephalitis in an immunocompromised adult. Clin Infect Dis. 2000;31:1113-4 pubmed
    ..We report an immunocompromised adult with encephalitis clinically consistent with HSE who had serology consistent with recent La Crosse encephalitis (LAC)...
  7. Jones T, Erwin P, Craig A, Baker P, Touhey K, Patterson L, et al. Serological survey and active surveillance for La Crosse virus infections among children in Tennessee. Clin Infect Dis. 2000;31:1284-7 pubmed
    ..Only 5 (0.5%) of 1000 serum samples being tested at the state laboratory for other diseases had evidence of antibodies to La Crosse virus. These findings suggest that La Crosse virus is newly endemic to eastern Tennessee.
  8. Kochs G, Janzen C, Hohenberg H, Haller O. Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc Natl Acad Sci U S A. 2002;99:3153-8 pubmed
    ..Here we demonstrate that MxA binds to the nucleocapsid protein of La Crosse virus (LACV) and colocalizes with the viral protein in cytoplasmic complexes...
  9. Kitron U, Michael J, Swanson J, Haramis L. Spatial analysis of the distribution of LaCrosse encephalitis in Illinois, using a geographic information system and local and global spatial statistics. Am J Trop Med Hyg. 1997;57:469-75 pubmed
    ..The GIS and spatial analysis may be useful in identifying and targeting for intervention potential sites of enzootic transmission. ..
  10. Jones T, Craig A, Nasci R, Patterson L, Erwin P, Gerhardt R, et al. Newly recognized focus of La Crosse encephalitis in Tennessee. Clin Infect Dis. 1999;28:93-7 pubmed
    b>La Crosse virus is a mosquito-borne arbovirus that causes encephalitis in children. Only nine cases were reported in Tennessee during the 33-year period from 1964-1996...
  11. Sokol D, Kleiman M, Garg B. LaCrosse viral encephalitis mimics herpes simplex viral encephalitis. Pediatr Neurol. 2001;25:413-5 pubmed
    ..The recently developed LaCrosse RNA polymerase chain reaction for cerebrospinal fluid may enable rapid diagnosis, prevent the need for treatment with acyclovir, and give parents an encouraging prognosis...
  12. Lambert A, Blair C, D Anton M, Ewing W, Harborth M, Seiferth R, et al. La Crosse virus in Aedes albopictus mosquitoes, Texas, USA, 2009. Emerg Infect Dis. 2010;16:856-8 pubmed publisher
    We report the arthropod-borne pediatric encephalitic agent La Crosse virus in Aedes albopictus mosquitoes collected in Dallas County, Texas, USA, in August 2009...
  13. Chandler L, Borucki M, Dobie D, Wasieloski L, Thompson W, Gundersen C, et al. Characterization of La Crosse virus RNA in autopsied central nervous system tissues. J Clin Microbiol. 1998;36:3332-6 pubmed
    ..The RT-PCR analyses of analyte directly from CNS tissues allows study of the virus without passage in cell culture...
  14. Gerhardt R, Gottfried K, Apperson C, Davis B, Erwin P, Smith A, et al. First isolation of La Crosse virus from naturally infected Aedes albopictus. Emerg Infect Dis. 2001;7:807-11 pubmed
  15. Hardin S, Erwin P, Patterson L, New D, Graber C, Halford S. Clinical comparisons of La Crosse encephalitis and enteroviral central nervous system infections in a pediatric population: 2001 surveillance in East Tennessee. Am J Infect Control. 2003;31:508-10 pubmed
    ..Studies comparing LAC cases with non-LAC (no etiologic diagnosis) central nervous system infections have yielded no statistical significance in signs and symptoms or laboratory values...
  16. Huang C, Thompson W, Karabatsos N, Grady L, Campbell W. Evidence that fatal human infections with La Crosse virus may be associated with a narrow range of genotypes. Virus Res. 1997;48:143-8 pubmed
    ..It is also shown that a virus with this genotype could be found circulating in mosquitoes in an area more or less intermediate between the locations of the first and second fatal cases...
  17. McJunkin J, Khan R, Tsai T. California-La Crosse encephalitis. Infect Dis Clin North Am. 1998;12:83-93 pubmed
    ..La Crosse encephalitis should be considered in the child presenting with meningoencephalitis in summer and early fall, particularly for children living in (or recent travel to) endemic areas in mid-Atlantic and midwestern states...
  18. Schuh T, Schultz J, Moelling K, Pavlovic J. DNA-based vaccine against La Crosse virus: protective immune response mediated by neutralizing antibodies and CD4+ T cells. Hum Gene Ther. 1999;10:1649-58 pubmed
    b>La Crosse virus (LACV)-mediated encephalitis is the most frequently reported arboviral disease in the United States, but to date no vaccine against this virus is available...
  19. Soldan S, Plassmeyer M, Matukonis M, Gonz lez Scarano F. La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA. J Virol. 2005;79:234-44 pubmed publisher
    ..b>La Crosse virus (LACV), a member of the California serogroup of orthobunyaviruses, has a trisegmented negative-stranded ..
  20. Kempf B, Blair C, Beaty B. Quantitative analysis of La Crosse virus transcription and replication in cell cultures and mosquitoes. Am J Trop Med Hyg. 2006;74:224-32 pubmed
    ..Coregulation of viral replication and mosquito ovary metabolic activity may condition efficient transovarial transmission...
  21. Pekosz A, Phillips J, Pleasure D, Merry D, Gonzalez Scarano F. Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention. J Virol. 1996;70:5329-35 pubmed
    b>La Crosse virus causes a highly cytopathic infection in cultured cells and in the murine central nervous system (CNS), with widespread neuronal destruction...
  22. Balkhy H, Schreiber J. Severe La Crosse encephalitis with significant neurologic sequelae. Pediatr Infect Dis J. 2000;19:77-80 pubmed
    ..Some of these eggs infected with La Crosse virus hatch the next spring and give rise to infected adult A. triseriatus, and the host-vector cycle is renewed...
  23. Kosoy O, Rabe I, Geissler A, Adjemian J, Panella A, Laven J, et al. Serological Survey for Antibodies to Mosquito-Borne Bunyaviruses Among US National Park Service and US Forest Service Employees. Vector Borne Zoonotic Dis. 2016;16:191-8 pubmed publisher
    ..The sera were analyzed for neutralizing antibodies against six orthobunyaviruses: La Crosse virus (LACV), Jamestown Canyon virus (JCV), snowshoe hare virus (SSHV), California encephalitis virus, and ..
  24. Carroll J, Striebel J, Rangel A, Woods T, Phillips K, Peterson K, et al. Prion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion Strains. PLoS Pathog. 2016;12:e1005551 pubmed publisher
  25. Osorio J, Godsey M, DeFoliart G, Yuill T. La Crosse viremias in white-tailed deer and chipmunks exposed by injection or mosquito bite. Am J Trop Med Hyg. 1996;54:338-42 pubmed
    To further understand the role of wild mammals in the maintenance of La Crosse virus (LACV) in nature, we investigated the effects of inoculation method and virus source on the duration and amplitude of LACV viremia in vertebrate hosts...
  26. Edwards J, Karabatsos N, Collisson E, de la Concha Bermejillo A. Ovine fetal malformations induced by in utero inoculation with Main Drain, San Angelo, and LaCrosse viruses. Am J Trop Med Hyg. 1997;56:171-6 pubmed
  27. Haddow A, Bixler D, Schuh A. The demographic and socioeconomic factors predictive for populations at high-risk for La Crosse virus infection in West Virginia. PLoS ONE. 2011;6:e25739 pubmed publisher
    Although a large body of literature exists for the environmental risk factors for La Crosse virus (LACV) transmission, the demographic and socioeconomic risk factors for developing LACV infection have not been investigated...
  28. Proença Módena J, Hyde J, Sesti Costa R, Lucas T, Pinto A, Richner J, et al. Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System. J Virol. 2016;90:189-205 pubmed publisher
    ..To define the role of IRF-5 during bunyavirus infection, we evaluated Oropouche virus (OROV) and La Crosse virus (LACV) pathogenesis and immune responses in primary cells and in mice with gene deletions in Irf3, Irf5, and ..
  29. Kallfass C, Ackerman A, Lienenklaus S, Weiss S, Heimrich B, Staeheli P. Visualizing production of beta interferon by astrocytes and microglia in brain of La Crosse virus-infected mice. J Virol. 2012;86:11223-30 pubmed
    ..Numerous luciferase-positive cells were detected in regions of La Crosse virus (LACV)-infected mouse brains that contained many infected cells...
  30. Mudhasani R, Tran J, Retterer C, Radoshitzky S, Kota K, Altamura L, et al. IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus. J Virol. 2013;87:8451-64 pubmed publisher
    ..activity against several members of the Bunyaviridae family, including Rift Valley fever virus (RVFV), La Crosse virus, Andes virus, and Hantaan virus, all of which can cause severe disease in humans and animals...
  31. Teleron A, Rose B, Williams D, Kemper S, McJunkin J. La Crosse Encephalitis: An Adult Case Series. Am J Med. 2016;129:881-4 pubmed publisher
    ..b>La Crosse Virus produces a clinically significant encephalitis in adults, and a high level of suspicion should be maintained, ..
  32. Winkler C, Woods T, Robertson S, McNally K, Carmody A, Best S, et al. Cutting Edge: CCR2 Is Not Required for Ly6Chi Monocyte Egress from the Bone Marrow but Is Necessary for Migration within the Brain in La Crosse Virus Encephalitis. J Immunol. 2018;200:471-476 pubmed publisher
    ..In this article, we show that during La Crosse Virus-induced encephalitis, egress of iMOs was surprisingly independent of CCR2, with similar percentages of iMOs ..
  33. Varela M, Piras I, Mullan C, Shi X, Tilston Lunel N, Pinto R, et al. Sensitivity to BST-2 restriction correlates with Orthobunyavirus host range. Virology. 2017;509:121-130 pubmed publisher
    ..We show that viruses with human tropism (Oropouche virus and La Crosse virus) are restricted by sheep BST-2 but not by the human orthologue, while viruses with ruminant tropism (..
  34. Graham D, Holmes J, Higgs S, Beaty B, Black W. Selection of refractory and permissive strains of Aedes triseriatus (Diptera: Culicidae) for transovarial transmission of La Crosse virus. J Med Entomol. 1999;36:671-8 pubmed
    The genetic basis of transovarial transmission of La Crosse virus in Aedes triseriatus (Say) was investigated through selection experiments on 2 mosquito strains...
  35. Sandrock M, Frese M, Haller O, Kochs G. Interferon-induced rat Mx proteins confer resistance to Rift Valley fever virus and other arthropod-borne viruses. J Interferon Cytokine Res. 2001;21:663-8 pubmed
    ..The results indicate that rats have evolved two Mx proteins to efficiently control viruses with different replication strategies. ..
  36. Scheidler L, Dunphy Daly M, White B, Andrew D, Mans N, Garvin M. Survey of Aedes triseriatus (Diptera: Culicidae) for Lacrosse encephalitis virus and West Nile virus in Lorain County, Ohio. J Med Entomol. 2006;43:589-93 pubmed
    ..22/1,000. None of 170 pools comprised of 2,158 females tested for WNV were positive. LACV-positive pools were detected between late July and early September. ..
  37. Black W, Vanlandingham D, Sweeney W, Wasieloski L, Calisher C, Beaty B. Typing of LaCrosse, snowshoe hare, and Tahyna viruses by analyses of single-strand conformation polymorphisms of the small RNA segments. J Clin Microbiol. 1995;33:3179-82 pubmed
    ..The resulting single-strand conformation polymorphism patterns were specific for the respective viruses. This molecular technique offers great potential for virus typing and taxonomic studies. ..
  38. Burgeson J, Moore A, Boutilier J, Cerruti N, Gharaibeh D, Lovejoy C, et al. SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity. Bioorg Med Chem Lett. 2012;22:4263-72 pubmed publisher
    ..25 ?M) and La Crosse virus (EC(50)=0.27 ?M) in cytopathic effect (CPE) assays...
  39. Harmon B, Bird S, Schudel B, Hatch A, Rasley A, Negrete O. A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection. J Virol. 2016;90:7084-7097 pubmed publisher
    ..Similar results were found using distantly related bunyaviruses La Crosse virus and California encephalitis virus, suggesting a conserved role for Wnt signaling in bunyaviral infection...
  40. Barker C, Brewster C, Paulson S. Spatiotemporal oviposition and habitat preferences of Ochlerotatus triseriatus and Aedes albopictus in an emerging focus of La Crosse virus. J Am Mosq Control Assoc. 2003;19:382-91 pubmed
    The number of cases of encephalitis caused by La Crosse virus recently has increased in southwestern Virginia counties...
  41. Mancao M, Law I, Roberson Trammell K. California encephalitis in Alabama. South Med J. 1996;89:992-3 pubmed
    ..This report stresses the importance of including California encephalitis in the differential diagnosis when children have fever and altered sensorium after exposure to mosquitoes during summer months...
  42. Lienenklaus S, Cornitescu M, Zietara N, Łyszkiewicz M, Gekara N, Jabłónska J, et al. Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. J Immunol. 2009;183:3229-36 pubmed publisher
    ..reporter mouse, we reveal strong tissue-specific induction of IFN-beta following infection with influenza or La Crosse virus. Importantly, this reporter mouse also allowed us to visualize that IFN-beta is expressed constitutively in ..
  43. Johnson A, Martin D, Karabatsos N, Roehrig J. Detection of anti-arboviral immunoglobulin G by using a monoclonal antibody-based capture enzyme-linked immunosorbent assay. J Clin Microbiol. 2000;38:1827-31 pubmed
    ..The tests were standardized for laboratory diagnosis of arboviral infections, with the intent that they be used in tandem with the corresponding IgM antibody-capture ELISAs...
  44. Brackney D, Scott J, Sagawa F, Woodward J, Miller N, Schilkey F, et al. C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl Trop Dis. 2010;4:e856 pubmed publisher
    ..Drosophila melanogaster S2 cells were infected with WNV (Flaviviridae), Sindbis virus (SINV, Togaviridae) and La Crosse virus (LACV, Bunyaviridae) and total RNA recovered from cell lysates...
  45. Gaensbauer J, Lindsey N, Messacar K, Staples J, Fischer M. Neuroinvasive arboviral disease in the United States: 2003 to 2012. Pediatrics. 2014;134:e642-50 pubmed publisher
    ..b>La Crosse virus (665 cases; 55%) and West Nile virus (505 cases; 41%) were the most common etiologies identified...
  46. Osorio J, Schoepp R, Yuill T. Effects of La Crosse virus infection on pregnant domestic rabbits and mongolian gerbils. Am J Trop Med Hyg. 1996;55:384-90 pubmed
    The transplacental transmission of La Crosse virus (LACV) was evaluated in domestic rabbits (Oryctolagus cuniculus) and Mongolian gerbils (Meriones unguiculatis) as a potential mechanism for the maintenance of the virus...
  47. Joy J, Hildreth Whitehair A. Larval habitat characterization for Aedes triseriatus (Say), the mosquito vector of LaCrosse encephalitis in West Virginia. Wilderness Environ Med. 2000;11:79-83 pubmed
  48. Sotir M, Glaser L, Fox P, Doering M, Geske D, Warshauer D, et al. Endemic human mosquito-borne disease in Wisconsin residents, 2002-2006. WMJ. 2007;106:185-90 pubmed
    West Nile virus (WNV) and La Crosse virus (LAC) are the primary mosquito-borne arboviruses associated with human disease in Wisconsin. We examined WNV and LAC human illness surveillance data collected during 2002 through 2006.
  49. Jackson B, Brewster C, Paulson S. La Crosse virus infection alters blood feeding behavior in Aedes triseriatus and Aedes albopictus (Diptera: Culicidae). J Med Entomol. 2012;49:1424-9 pubmed
    The effects of La Crosse virus (LACV) infection on blood feeding behavior in Aedes triseriatus (Say) and Aedes albopictus (Skuse) were investigated in the laboratory by measuring the size of the bloodmeal imbibed and the extent of ..
  50. Osorio J, Yuill T. La Crosse viremias in Mongolian gerbils (Meriones unguiculatis). Am J Trop Med Hyg. 1996;55:567-9 pubmed
    We examined the usefulness of mongolian gerbils (Meriones unguiculatus) as a new animal model for La Crosse virus (LACV) studies...
  51. Kitron U, Swanson J, Crandell M, Sullivan P, Anderson J, Garro R, et al. Introduction of Aedes albopictus into a La Crosse virus--enzootic site in Illinois. Emerg Infect Dis. 1998;4:627-30 pubmed
    ..summer and fall 1997, Aedes albopictus mosquitoes were found in Peoria, Illinois, a long recognized focus of La Crosse virus transmission...
  52. Ravkov E, Compans R. Hantavirus nucleocapsid protein is expressed as a membrane-associated protein in the perinuclear region. J Virol. 2001;75:1808-15 pubmed
    ..Immunofluorescence analysis of BHK21 cells expressing the NBCCV and La Crosse virus nucleocapsid protein (NLACV) showed different intracellular localization patterns of these proteins within ..
  53. Lobo N, Li X, Hua Van A, Fraser M. Mobility of the piggyBac transposon in embryos of the vectors of Dengue fever (Aedes albopictus) and La Crosse encephalitis (Ae. triseriatus). Mol Genet Genomics. 2001;265:66-71 pubmed
    ..The mobility of the piggyBac element seen in both Ae. albopictus and Ae. triseriatus is further evidence that it can be employed as a germ-line vector in important insect disease vectors. ..
  54. Verbruggen P, Ruf M, Blakqori G, Overby A, Heidemann M, Eick D, et al. Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II. J Biol Chem. 2011;286:3681-92 pubmed publisher
  55. Leisnham P, Juliano S. Impacts of climate, land use, and biological invasion on the ecology of immature Aedes mosquitoes: implications for La Crosse emergence. Ecohealth. 2012;9:217-28 pubmed publisher
    ..b>La Crosse virus (LACV) is historically transmitted by the native mosquito Aedes triseriatus (Say) in the upper Midwestern US, ..
  56. Reguera J, Malet H, Weber F, Cusack S. Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein. Proc Natl Acad Sci U S A. 2013;110:7246-51 pubmed publisher
    ..This work gives insight into the RNA encapsidation and protection function of bunyavirus NP, but also highlights the need for dynamic rearrangements of the RNP to give the polymerase access to the template RNA. ..
  57. Aquino V, Moreli M, Moraes Figueiredo L. Analysis of oropouche virus L protein amino acid sequence showed the presence of an additional conserved region that could harbour an important role for the polymerase activity. Arch Virol. 2003;148:19-28 pubmed
    ..These comparisons also showed the existence of an additional fourth conserved region in the L protein of bunyaviruses that contains at least two active sites. ..
  58. Connor J, McKenzie M, Parks G, Lyles D. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007;362:109-19 pubmed
    ..Based on these results, we propose that Hsp90 is a host factor that is important for the replication of many negative strand viruses. ..
  59. Perry J, Ahmed M, Chang K, Donato N, Showalter H, Wobus C. Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. PLoS Pathog. 2012;8:e1002783 pubmed publisher
    ..the UPR also reduced infection of other RNA viruses including encephalomyocarditis virus, Sindbis virus, and La Crosse virus but not vesicular stomatitis virus...
  60. Operschall E, Schuh T, Heinzerling L, Pavlovic J, Moelling K. Enhanced protection against viral infection by co-administration of plasmid DNA coding for viral antigen and cytokines in mice. J Clin Virol. 1999;13:17-27 pubmed
    ..We have recently demonstrated that DNA vaccine induced protective immunity against influenza A virus and La Crosse virus (LACV) is primarily mediated by humoral immune response...
  61. Pavlovic J, Schultz J, Hefti H, Schuh T, Molling K. DNA vaccination against La Crosse virus. Intervirology. 2000;43:312-21 pubmed
    ..IL-12 enhanced the survival of mice following viral challenge, but the effect was independent of N indicating the involvement of components of the innate immune system such as NK cells...
  62. Conley A, Watling J, Orrock J. Invasive plant alters ability to predict disease vector distribution. Ecol Appl. 2011;21:329-34 pubmed
    ..Lonicera maackii, affects oviposition by treehole mosquitoes, Aedes triseriatus, a primary vector of La Crosse virus in the United States. Oviposition significantly decreased with increasing density of L. maackii...
  63. D ANGELO W, Acharya D, Wang R, Wang J, Gurung C, Chen B, et al. Development of Antiviral Innate Immunity During In Vitro Differentiation of Mouse Embryonic Stem Cells. Stem Cells Dev. 2016;25:648-59 pubmed publisher
    ..Together with our previously published study, the current data provide important insights into molecular basis for the deficiency of IFN expression in mESCs and the development of antiviral innate immunity during mESC differentiation. ..
  64. Knapp J, Love J, Singer J. An adolescent with flaccid monoplegia. Pediatr Emerg Care. 2002;18:209-11 pubmed
  65. Westby K, Muturi E, Juliano S. How do Nutritional Stress and La Crosse Virus Infection Interact? Tests for Effects on Willingness to Blood Feed and Fecundity in Aedes albopictus (Diptera: Culicidae). J Med Entomol. 2016;53:166-71 pubmed publisher
    ..virulence by examining the interactive effects of short-term sugar deprivation and exposure to La Crosse virus (LACV) in female Aedes albopictus (Skuse)...
  66. Lambert A, Nasci R, Cropp B, Martin D, Rose B, Russell B, et al. Nucleic acid amplification assays for detection of La Crosse virus RNA. J Clin Microbiol. 2005;43:1885-9 pubmed
    ..The NASBA and quantitative real-time RT-PCR assays detect LAC viral RNA in a sensitive, specific, and rapid manner; these findings support the use of these assays in surveillance and diagnostic laboratory systems. ..
  67. Haddow A, Haddow A. The use of oral ribavirin in the management of La Crosse viral infections. Med Hypotheses. 2009;72:190-2 pubmed publisher
    ..We propose that oral ribavirin may provide a useful treatment to limit the severity and improve the prognosis of those suffering from LAC viral infections. ..