hantavirus

Summary

Summary: A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. Infection is found primarily in rodents and humans. Transmission does not appear to involve arthropods. HANTAAN VIRUS is the type species.

Top Publications

  1. Zhang Y, Yuan J, Yang X, Zhou J, Yang W, Peng C, et al. A novel hantavirus detected in Yunnan red-backed vole (Eothenomys miletus) in China. J Gen Virol. 2011;92:1454-7 pubmed publisher
    ..hantaviruses, which cause two main human zoonoses, haemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus pulmonary syndrome (HPS) in the Americas...
  2. Radosa L, Schlegel M, Gebauer P, Ansorge H, Heroldová M, Janova E, et al. Detection of shrew-borne hantavirus in Eurasian pygmy shrew (Sorex minutus) in Central Europe. Infect Genet Evol. 2013;19:403-10 pubmed publisher
    ..Three new hantavirus partial L-segment sequences were obtained from pygmy shrews (Sorex minutus) trapped in Czech Republic and ..
  3. Armien B, Pascale J, Munoz C, Mariñas J, Núñez H, Herrera M, et al. Hantavirus fever without pulmonary syndrome in Panama. Am J Trop Med Hyg. 2013;89:489-94 pubmed publisher
    In Panama, hantavirus pulmonary syndrome (HPS) is caused by Choclo virus, a species phylogenetically related to Andes and Maporal viruses...
  4. Kang H, Arai S, Hope A, Song J, Cook J, Yanagihara R. Genetic diversity and phylogeography of Seewis virus in the Eurasian common shrew in Finland and Hungary. Virol J. 2009;6:208 pubmed publisher
    Recent identification of a newfound hantavirus, designated Seewis virus (SWSV), in the Eurasian common shrew (Sorex araneus), captured in Switzerland, corroborates decades-old reports of hantaviral antigens in this shrew species from ..
  5. Safronetz D, Falzarano D, Scott D, Furuta Y, Feldmann H, Gowen B. Antiviral efficacy of favipiravir against two prominent etiological agents of hantavirus pulmonary syndrome. Antimicrob Agents Chemother. 2013;57:4673-80 pubmed publisher
    b>Hantavirus pulmonary syndrome (HPS) is caused by infection with several Sigmodontinae- and Neotominae-borne hantaviruses and has a case fatality rate of 30 to 50%...
  6. Popugaeva E, Witkowski P, Schlegel M, Ulrich R, Auste B, Rang A, et al. Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLoS ONE. 2012;7:e35587 pubmed publisher
    Dobrava-Belgrade virus (DOBV) is a European hantavirus causing hemorrhagic fever with renal syndrome (HFRS) in humans with fatality rates of up to 12%...
  7. Nemeth V, Oldal M, Madai M, Horváth G, Kemenesi G, Dallos B, et al. Molecular characterization of Dobrava and Kurkino genotypes of Dobrava-Belgrade hantavirus detected in Hungary and Northern Croatia. Virus Genes. 2013;47:546-9 pubmed publisher
    Among the Hantavirus genus, Saaremaa virus (SAAV) has been the subject of taxonomical debates...
  8. Alff P, Sen N, Gorbunova E, Gavrilovskaya I, Mackow E. The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation. J Virol. 2008;82:9115-22 pubmed publisher
    ..replicate within human endothelial cells and cause two diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome...
  9. Chang B, Crowley M, Campen M, Koster F. Hantavirus cardiopulmonary syndrome. Semin Respir Crit Care Med. 2007;28:193-200 pubmed
    b>Hantavirus cardiopulmonary syndrome (HCPS) is caused by infection with multiple types of hantaviruses throughout the Americas...

More Information

Publications170 found, 100 shown here

  1. CHUNG D, Kumarapperuma S, Sun Y, Li Q, Chu Y, Arterburn J, et al. Synthesis of 1-beta-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus. Antiviral Res. 2008;79:19-27 pubmed publisher
    ..ETAR is an exciting and promising lead compound that will be elaborated in further synthetic investigations as a framework for the rational design of new antivirals for treatment of HFRS. ..
  2. Bi Z, Formenty P, Roth C. Hantavirus infection: a review and global update. J Infect Dev Ctries. 2008;2:3-23 pubmed
    ..potential to cause two different types of diseases in human: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS)...
  3. Kang H, Kosoy M, Shrestha S, Shrestha M, Pavlin J, Gibbons R, et al. Short report: Genetic diversity of Thottapalayam virus, a Hantavirus harbored by the Asian house shrew (Suncus murinus) in Nepal. Am J Trop Med Hyg. 2011;85:540-5 pubmed publisher
    ..regions, data are unavailable about the genetic diversity and phylogeography of Thottapalayam virus (TPMV), a hantavirus originally isolated from an Asian house shrew (Suncus murinus) captured in southern India more than four decades ..
  4. Sarıgüzel N, Hofmann J, Canpolat A, Turk A, Ettinger J, Atmaca D, et al. Dobrava hantavirus infection complicated by panhypopituitarism, Istanbul, Turkey, 2010. Emerg Infect Dis. 2012;18:1180-3 pubmed publisher
    We identified Dobrava-Belgrade virus infection in Turkey (from a strain related to hantavirus strains from nearby countries) in a patient who had severe symptoms leading to panhypopituitarism, but no known risk for hantavirus...
  5. Kucinskaite Kodze I, Petraityte Burneikiene R, Zvirbliene A, Hjelle B, Medina R, Gedvilaite A, et al. Characterization of monoclonal antibodies against hantavirus nucleocapsid protein and their use for immunohistochemistry on rodent and human samples. Arch Virol. 2011;156:443-56 pubmed publisher
    Monoclonal antibodies are important tools for various applications in hantavirus diagnostics...
  6. Sun L, Shao Q, Wang Z, Kang D, Li S, Li X, et al. Spatial structure of rodent populations and infection patterns of hantavirus in seven villages of Shandong Province from February 2006 to January 2007. Chin Med J (Engl). 2011;124:1639-46 pubmed
    ..spatial analysis with the objective of estimating the spatial distribution of rodent populations and their hantavirus infection patterns, to describe the spatial relationships of hantavirus strains in small ecological areas and to ..
  7. Cheng E, Mir M. Signatures of host mRNA 5' terminus for efficient hantavirus cap snatching. J Virol. 2012;86:10173-85 pubmed publisher
    ..b>Hantavirus nucleocapsid protein (N) binds to host mRNA caps and requires four nucleotides adjacent to the 5' cap for high-..
  8. Zou Y, Hu J, Wang Z, Wang D, Yu C, Zhou J, et al. Genetic characterization of hantaviruses isolated from Guizhou, China: evidence for spillover and reassortment in nature. J Med Virol. 2008;80:1033-41 pubmed publisher
    ..Our results also suggest that HTNV from A. agrarius spilled over to R. norvegicus and natural reassortment between HTNV and SEOV occurred during or after the spillover. ..
  9. Arai S, Ohdachi S, Asakawa M, Kang H, Mocz G, Arikawa J, et al. Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides). Proc Natl Acad Sci U S A. 2008;105:16296-301 pubmed publisher
    ..hantaviruses in shrews, captured in widely separated geographical regions, corroborates decades-old reports of hantavirus antigens in shrew tissues...
  10. Chandy S, Yoshimatsu K, Boorugu H, Chrispal A, Thomas K, Peedicayil A, et al. Acute febrile illness caused by hantavirus: serological and molecular evidence from India. Trans R Soc Trop Med Hyg. 2009;103:407-12 pubmed publisher
    Study of hantavirus infections in India is in its early stages. As early symptoms of hantavirus disease can be non-specific and the diagnosis confirmed only by laboratory testing, use of appropriate diagnostic tools is important...
  11. Zou Y, Xiao Q, Dong X, Lv W, Zhang S, Li M, et al. Genetic analysis of hantaviruses carried by reed voles Microtus fortis in China. Virus Res. 2008;137:122-8 pubmed publisher
    ..The newly characterized sequences from Yuanjiang might represent a novel distinct hantavirus species. Our results also demonstrated the great genetic diversity and complexity of the M...
  12. Suzán G, Marcé E, Giermakowski J, Mills J, Ceballos G, Ostfeld R, et al. Experimental evidence for reduced rodent diversity causing increased hantavirus prevalence. PLoS ONE. 2009;4:e5461 pubmed publisher
    ..Our results have wide applications in both conservation biology and infectious disease management. ..
  13. Klempa B, Avsic Zupanc T, Clement J, Dzagurova T, Henttonen H, Heyman P, et al. Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics. Arch Virol. 2013;158:521-9 pubmed publisher
  14. Wang H, Strandin T, Hepojoki J, Lankinen H, Vaheri A. Degradation and aggresome formation of the Gn tail of the apathogenic Tula hantavirus. J Gen Virol. 2009;90:2995-3001 pubmed publisher
    ..We conclude that degradation upon aggregation of Gn tails, which may represent a general cellular response to misfolded protein used by hantaviruses to control maturation of virions, is unrelated to pathogenicity. ..
  15. Nelson R, Cañate R, Pascale J, Dragoo J, Armien B, Armien A, et al. Confirmation of Choclo virus as the cause of hantavirus cardiopulmonary syndrome and high serum antibody prevalence in Panama. J Med Virol. 2010;82:1586-93 pubmed publisher
    ..virus (CHOV) was described in sigmodontine rodents, Oligoryzomys fulvescens, and humans during an outbreak of hantavirus cardiopulmonary syndrome (HCPS) in 1999-2000 in western Panama...
  16. Kramski M, Meisel H, Klempa B, Kruger D, Pauli G, Nitsche A. Detection and typing of human pathogenic hantaviruses by real-time reverse transcription-PCR and pyrosequencing. Clin Chem. 2007;53:1899-905 pubmed
    ..To date, the diagnosis of hantavirus infection is based mainly on serologic assays, and the detection of hantaviral RNA by the commonly used reverse ..
  17. Virtanen J, Jääskeläinen K, Djupsjöbacka J, Vaheri A, Plyusnin A. Tula hantavirus NSs protein accumulates in the perinuclear area in infected and transfected cells. Arch Virol. 2010;155:117-21 pubmed publisher
    ..The hantavirus NSs protein, like those of orthobunya- and phleboviruses, counteracts host innate immunity...
  18. Pereira G, Teixeira A, Souza M, Braga A, Santos Junior G, Figueiredo G, et al. Prevalence of serum antibodies to hantavirus in a rural population from the Southern State of Santa Catarina, Brazil. Rev Soc Bras Med Trop. 2012;45:117-9 pubmed
    Rodent-borne hantaviruses cause severe human diseases. We completed a serological survey of hantavirus infection in rural inhabitants of Turvo County, in the southern State of Santa Catarina, Brazil, in which seropositivity for hantavirus ..
  19. Li J, Li K, Gao J, Cui J, Liu Y, Yang S. Heat shock protein 70 fused to or complexed with hantavirus nucleocapsid protein significantly enhances specific humoral and cellular immune responses in C57BL/6 mice. Vaccine. 2008;26:3175-87 pubmed publisher
    ..These results indicated that HSP70, when fused to or complexed with HTNV NP, greatly enhance NP vaccine potency by preferential induction of a predominant Th1 immune response in a NP-specific, HSP70-dependent manner. ..
  20. Buys K, Jung K, Smee D, Furuta Y, Gowen B. Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir. Antivir Chem Chemother. 2011;21:193-200 pubmed publisher
    ..haemorrhagic fever with renal syndrome (HFRS), whereas New World hantaviruses are the aetiological agents of hantavirus cardiopulmonary syndrome (HCPS)...
  21. Kariwa H, Yoshida H, Sánchez Hernández C, Romero Almaraz M, Almazán Catalán J, Ramos C, et al. Genetic diversity of hantaviruses in Mexico: identification of three novel hantaviruses from Neotominae rodents. Virus Res. 2012;163:486-94 pubmed publisher
    A variety of hantaviruses are harbored by rodents in North and South America, some of which can cause hantavirus pulmonary syndrome...
  22. Jakab F, Sebok J, Ferenczi E, Horváth G, Szucs G. First detection of Dobrava hantavirus from a patient with severe haemorrhagic fever with renal syndrome by SYBR Green-based real time RT-PCR. Scand J Infect Dis. 2007;39:902-6 pubmed
    Dobrava hantavirus (DOBV) infection was diagnosed in a previously healthy 46-y-old hunter suffering from severe haemorrhagic fever with renal syndrome (HFRS)...
  23. Tischler N, Rosemblatt M, Valenzuela P. Characterization of cross-reactive and serotype-specific epitopes on the nucleocapsid proteins of hantaviruses. Virus Res. 2008;135:1-9 pubmed publisher
    The hantavirus nucleocapsid (N) protein fulfills several key roles in virus replication and assembly and is the major antigen in humoral immune responses in humans and mice...
  24. Oliveira R, Guterres A, Schrago C, Fernandes J, Teixeira B, Zeccer S, et al. Detection of the first incidence of Akodon paranaensis naturally infected with the Jabora virus strain (Hantavirus) in Brazil. Mem Inst Oswaldo Cruz. 2012;107:424-8 pubmed
    ..different Akodon rodent species collected in midwestern Santa Catarina (SC), southern Brazil, where the Jabora hantavirus (JABV) strain was first identified in Akodon montensis...
  25. Krautkrämer E, Zeier M, Plyusnin A. Hantavirus infection: an emerging infectious disease causing acute renal failure. Kidney Int. 2013;83:23-7 pubmed publisher
    ..The classification refers to geographical distribution: New World hantaviruses causing hantavirus cardiopulmonary syndrome (HCPS) and Old World hantaviruses causing hemorrhagic fever with renal syndrome (HFRS)...
  26. Lindkvist M, Näslund J, Ahlm C, Bucht G. Cross-reactive and serospecific epitopes of nucleocapsid proteins of three hantaviruses: prospects for new diagnostic tools. Virus Res. 2008;137:97-105 pubmed publisher
    ..blot analysis on a panel of N protein derivatives and alanine-substitution mutants in the three different hantavirus backgrounds...
  27. Maes P, Clement J, Van Ranst M. Recent approaches in hantavirus vaccine development. Expert Rev Vaccines. 2009;8:67-76 pubmed publisher
    ..are associated with two main clinical disorders in humans: hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome...
  28. Truong T, Yoshimatsu K, Araki K, Lee B, Nakamura I, Endo R, et al. Molecular epidemiological and serological studies of hantavirus infection in northern Vietnam. J Vet Med Sci. 2009;71:1357-63 pubmed
    The distribution of anti-hantavirus antibodies in humans and rodents in northern Vietnam was examined...
  29. Pepini T, Gorbunova E, Gavrilovskaya I, Mackow J, Mackow E. Andes virus regulation of cellular microRNAs contributes to hantavirus-induced endothelial cell permeability. J Virol. 2010;84:11929-36 pubmed publisher
    ..and cause two diseases marked by vascular permeability defects, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS)...
  30. Papa A. Dobrava-Belgrade virus: phylogeny, epidemiology, disease. Antiviral Res. 2012;95:104-17 pubmed publisher
    Dobrava-Belgrade virus (DOBV) is an Old World hantavirus that causes hemorrhagic fever with renal syndrome in humans. With a case fatality rate up to 12%, DOBV infection is the most life-threatening hantavirus disease in Europe...
  31. Schlegel M, Tegshduuren E, Yoshimatsu K, Petraityte R, Sasnauskas K, Hammerschmidt B, et al. Novel serological tools for detection of Thottapalayam virus, a Soricomorpha-borne hantavirus. Arch Virol. 2012;157:2179-87 pubmed publisher
    We developed serological tools for the detection of hantavirus-specific antibodies and hantavirus antigens in shrews...
  32. Klempa B, Fichet Calvet E, Lecompte E, Auste B, Aniskin V, Meisel H, et al. Novel hantavirus sequences in Shrew, Guinea. Emerg Infect Dis. 2007;13:520-2 pubmed
  33. Safronetz D, Zivcec M, LaCasse R, Feldmann F, Rosenke R, Long D, et al. Pathogenesis and host response in Syrian hamsters following intranasal infection with Andes virus. PLoS Pathog. 2011;7:e1002426 pubmed publisher
    b>Hantavirus pulmonary syndrome (HPS), also referred to as hantavirus cardiopulmonary syndrome (HCPS), is a rare but frequently fatal disease caused by New World hantaviruses...
  34. Li P, Yu L, Wu X, Bai W, Li K, Wang H, et al. Modification of the adenoviral transfer vector enhances expression of the Hantavirus fusion protein GnS0.7 and induces a strong immune response in C57BL/6 mice. J Virol Methods. 2012;179:90-6 pubmed publisher
    b>Hantavirus glycoproteins (Gn and Gc) are significant components of vaccines for haemorrhagic fever with renal syndrome (HFRS); however, they are not effective due to weak immunogenicity and low levels of production in expression systems...
  35. Castillo Oré R, Forshey B, Huaman A, Villaran M, Long K, Kochel T, et al. Serologic evidence for human hantavirus infection in Peru. Vector Borne Zoonotic Dis. 2012;12:683-9 pubmed publisher
    While human illness associated with hantavirus infection has been documented in many countries of South America, evidence for hantavirus transmission in Peru has been limited to the isolation of Rio Mamore virus from a pigmy mouse rat (..
  36. Zhang Y, Zou Y, Fu Z, Plyusnin A. Hantavirus infections in humans and animals, China. Emerg Infect Dis. 2010;16:1195-203 pubmed publisher
    ..Mortality rates also declined from the highest level of 14.2% in 1969 to ?1% during 1995-2007. However, the numbers of HFRS cases and deaths in China remain the highest in the world. ..
  37. de Oliveira R, Padula P, Gomes R, Martinez V, Bellomo C, Bonvicino C, et al. Genetic characterization of hantaviruses associated with sigmodontine rodents in an endemic area for hantavirus pulmonary syndrome in southern Brazil. Vector Borne Zoonotic Dis. 2011;11:301-14 pubmed publisher
    ..was conducted in a rural area (Jaborá) in the mid-west of the state of Santa Catarina in southern Brazil, where hantavirus pulmonary syndrome is endemic, to evaluate the prevalence of hantavirus infection in wild rodents...
  38. Figueiredo G, Borges A, Campos G, Machado A, Saggioro F, Sabino Júnior G, et al. Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil. Rev Soc Bras Med Trop. 2010;43:348-54 pubmed
    b>Hantavirus pulmonary and cardiovascular syndrome (HPCS) is an emerging serious disease in the Americas...
  39. Adesiyun A, Dookeran S, Stewart Johnson A, Rahaman S, Bissessar S, Thompson N. Serological evidence of hantavirus infection in farm and abattoir workers in Trinidad--a preliminary study. J Agromedicine. 2011;16:194-9 pubmed publisher
    ..a selected apparently healthy human population associated with abattoirs and livestock farms in Trinidad using a hantavirus immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA). Of a total of 236 individuals tested, 27 (11...
  40. Figueiredo L, Moreli M, Borges A, de Figueiredo G, Badra S, Bisordi I, et al. Evaluation of an enzyme-linked immunosorbent assay based on Araraquara virus recombinant nucleocapsid protein. Am J Trop Med Hyg. 2009;81:273-6 pubmed
    Laboratory diagnosis of hantavirus cardiopulmonary syndrome (HCPS) in Brazil has been performed mostly by detection of IgM antibodies to recombinant antigen purified from Sin Nombre virus and Andes virus (ANDV)...
  41. Londoño A, Diaz F, Agudelo Florez P, Levis S, Rodas J. Genetic evidence of hantavirus infections in wild rodents from northwestern Colombia. Vector Borne Zoonotic Dis. 2011;11:701-8 pubmed publisher
    This report builds on recent serological evidence for the presence of hantavirus in northern Colombia by providing sequence-specific and phylogenetic data of hantavirus infections in wild rodents...
  42. Nakamura I, Yoshimatsu K, Lee B, Okumura M, Taruishi M, Araki K, et al. Development of a serotyping ELISA system for Thailand virus infection. Arch Virol. 2008;153:1537-42 pubmed publisher
    ..In evaluations using patient and rodent sera, Thailand virus infection was readily distinguished from Hantaan and Seoul virus infections. Therefore, this ELISA system is an effective alternative to neutralization tests...
  43. Raboni S, Hoffmann F, Oliveira R, Teixeira B, Bonvicino C, Stella V, et al. Phylogenetic characterization of hantaviruses from wild rodents and hantavirus pulmonary syndrome cases in the state of Parana (southern Brazil). J Gen Virol. 2009;90:2166-71 pubmed publisher
    Over 1,100 cases of hantavirus pulmonary syndrome (HPS) have occurred in Brazil since 1993, but little is known about Brazilian hantaviruses, and many of their rodent hosts remain unknown...
  44. Hanson J, Utrera A, Fulhorst C. The delicate pygmy rice rat (Oligoryzomys delicatus) is the principal host of Maporal virus (family Bunyaviridae, genus Hantavirus). Vector Borne Zoonotic Dis. 2011;11:691-6 pubmed publisher
    ..As such, MAPV is ecologically distinct from CHOV and should be considered a species separate from CHOV. ..
  45. Machado A, de Souza W, de Pádua M, da Silva Rodrigues Machado A, Figueiredo L. Development of a one-step SYBR Green I real-time RT-PCR assay for the detection and quantitation of Araraquara and Rio Mamore hantavirus. Viruses. 2013;5:2272-81 pubmed publisher
    ..SYBR Green real-time RT-PCR was developed for the detection and quantitation of Araraquara (ARAV) and Rio Mamore hantavirus (RIOMV). The detection limit of assay was 10 copies/?L of RNA in vitro transcribed of segment S...
  46. Jääskeläinen K, Kaukinen P, Minskaya E, Plyusnina A, Vapalahti O, Elliott R, et al. Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter. J Med Virol. 2007;79:1527-36 pubmed
    ..The findings may explain why the NSs ORF has been preserved in the genome of most hantaviruses during their long evolution and why hantavirus-infected cells secrete relatively low levels of IFNs.
  47. Moutschen P, Bourhaba M, Frippiat F, Giot J, Meuris C, Leonard P, et al. A pauci-symptomatic case of documented Hantavirus (Puumala) infection in a patient under anti-TNF treatment. J Clin Virol. 2011;50:247-8 pubmed publisher
    ..The case illustrates that anti-TNF treatment does not worsen the course of Puumala infection and could even be associated with a milder clinical picture. ..
  48. Guterres A, de Oliveira R, Fernandes J, D Andrea P, Bonvicino C, Bragagnolo C, et al. Phylogenetic analysis of the S segment from Juquitiba hantavirus: identification of two distinct lineages in Oligoryzomys nigripes. Infect Genet Evol. 2013;18:262-8 pubmed publisher
    ..Wild rodents infected with the Juquitiba virus (JUQV) were sampled from a non-Hantavirus Cardiopulmonary Syndrome endemic area in Brazil. Three strains from O...
  49. Saksida A, Duh D, Korva M, Avsic Zupanc T. Dobrava virus RNA load in patients who have hemorrhagic fever with renal syndrome. J Infect Dis. 2008;197:681-5 pubmed publisher
    ..15 vs. 4.67 log(10) copies/mL; P = .053). These results suggest that the Dobrava virus load might be associated with the severity of disease...
  50. Hepojoki J, Strandin T, Wang H, Vapalahti O, Vaheri A, Lankinen H. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J Gen Virol. 2010;91:2341-50 pubmed publisher
    ..interaction between the glycoproteins (Gn and Gc) and the ribonucleoprotein (RNP) of Puumala virus (PUUV; genus Hantavirus, family Bunyaviridae)...
  51. Vaheri A, Vapalahti O, Plyusnin A. How to diagnose hantavirus infections and detect them in rodents and insectivores. Rev Med Virol. 2008;18:277-88 pubmed publisher
    ..can infect humans and many of them cause either haemorrhagic fever with renal syndrome (HFRS) in Eurasia or hantavirus cardiopulmonary syndrome (HCPS) in the Americas...
  52. Wahl Jensen V, Chapman J, Asher L, Fisher R, Zimmerman M, Larsen T, et al. Temporal analysis of Andes virus and Sin Nombre virus infections of Syrian hamsters. J Virol. 2007;81:7449-62 pubmed
    ..Nombre virus (SNV) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome (HPS)...
  53. Song J, Gu S, Bennett S, Arai S, Puorger M, Hilbe M, et al. Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus). Virol J. 2007;4:114 pubmed
    ..Using RT-PCR, sequences of a genetically distinct hantavirus, designated Seewis virus (SWSV), were amplified from lung tissue of a Eurasian common shrew, captured in October ..
  54. Eyzaguirre E, Milazzo M, Koster F, Fulhorst C. Choclo virus infection in the Syrian golden hamster. Am J Trop Med Hyg. 2008;78:669-74 pubmed
    Andes virus and Choclo virus are agents of hantavirus pulmonary syndrome. Andes virus in hamsters almost always causes a disease that is pathologically indistinguishable from fatal hantavirus pulmonary syndrome...
  55. Easterbrook J, Klein S. Immunological mechanisms mediating hantavirus persistence in rodent reservoirs. PLoS Pathog. 2008;4:e1000172 pubmed publisher
    ..Recent studies indicate that during hantavirus infection, proinflammatory and antiviral responses are reduced and regulatory responses are elevated at sites of ..
  56. Figueiredo L, Moreli M, de Sousa R, Borges A, de Figueiredo G, Machado A, et al. Hantavirus pulmonary syndrome, central plateau, southeastern, and southern Brazil. Emerg Infect Dis. 2009;15:561-7 pubmed publisher
    b>Hantavirus pulmonary syndrome (HPS) is an increasing health problem in Brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily Sigmodontinae rodents, which serve as hantavirus ..
  57. Taylor S, Krempel R, Schmaljohn C. Inhibition of TNF-alpha-induced activation of NF-kappaB by hantavirus nucleocapsid proteins. Ann N Y Acad Sci. 2009;1171 Suppl 1:E86-93 pubmed publisher
    ..cause two human diseases thought to be immune-mediated: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS)...
  58. Mills J, Amman B, Glass G. Ecology of hantaviruses and their hosts in North America. Vector Borne Zoonotic Dis. 2010;10:563-74 pubmed publisher
    Since the 1993 discovery of a highly pathogenic hantavirus associated with the North American deer mouse (Peromyscus maniculatus), intensive ecological studies have led to many advances in our understanding of the natural history of New ..
  59. Koma T, Yoshimatsu K, Pini N, Safronetz D, Taruishi M, Levis S, et al. Truncated hantavirus nucleocapsid proteins for serotyping Sin Nombre, Andes, and Laguna Negra hantavirus infections in humans and rodents. J Clin Microbiol. 2010;48:1635-42 pubmed publisher
    ..SNV), Andes virus (ANDV), and Laguna Negra virus (LANV) have been known as the dominant causative agents of hantavirus pulmonary syndrome (HPS)...
  60. Yadav P, Vincent M, Nichol S. Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus). Virol J. 2007;4:80 pubmed
    Thottapalayam (TPM) virus belongs to the genus Hantavirus, family Bunyaviridae...
  61. Krautkrämer E, Zeier M. Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55). J Virol. 2008;82:4257-64 pubmed publisher
    ..The polarized epithelial and endothelial cells were found to be susceptible to hantavirus infection exclusively from the apical surface...
  62. Chu Y, Goodin D, Owen R, Koch D, Jonsson C. Sympatry of 2 hantavirus strains, paraguay, 2003-2007. Emerg Infect Dis. 2009;15:1977-80 pubmed publisher
    ..We detected Jabora virus and Itapua37/Juquitiba-related virus in locations approximately 20 m apart in different years, which suggested sympatry of 2 distinct hantaviruses. ..
  63. Dearing M, Dizney L. Ecology of hantavirus in a changing world. Ann N Y Acad Sci. 2010;1195:99-112 pubmed publisher
    b>Hantavirus is a genus of virus represented by 45 different species and is hosted by small mammals, predominantly rats and mice. Roughly, half of all hantaviruses cause diseases in humans that vary in morbidity from mild to severe...
  64. Kirsanovs S, Klempa B, Franke R, Lee M, Schönrich G, Rang A, et al. Genetic reassortment between high-virulent and low-virulent Dobrava-Belgrade virus strains. Virus Genes. 2010;41:319-28 pubmed publisher
    ..The contrasting phenotypes of the parental viruses were maintained by the reassortants carrying the respective S and L segments of the parental virus and were not influenced by the origin of the M segment. ..
  65. Kruger D, Schönrich G, Klempa B. Human pathogenic hantaviruses and prevention of infection. Hum Vaccin. 2011;7:685-93 pubmed
    ..When transmitted to humans, they can cause two clinical syndromes, hemorrhagic fever with renal syndrome or hantavirus cardiopulmonary syndrome...
  66. Brown K, Safronetz D, Marzi A, Ebihara H, Feldmann H. Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus. J Virol. 2011;85:12781-91 pubmed publisher
    Andes virus (ANDV) is a highly pathogenic South American hantavirus that causes hantavirus pulmonary syndrome (HPS)...
  67. Schlegel M, Kindler E, Essbauer S, Wolf R, Thiel J, Groschup M, et al. Tula virus infections in the Eurasian water vole in Central Europe. Vector Borne Zoonotic Dis. 2012;12:503-13 pubmed publisher
    ..Tula virus (TULV), a European hantavirus, is believed to be slightly or non-pathogenic in humans and was initially detected in the common vole Microtus ..
  68. Mills J, Schmidt K, Ellis B, Calderón G, Enria D, Ksiazek T. A longitudinal study of hantavirus infection in three sympatric reservoir species in agroecosystems on the Argentine Pampa. Vector Borne Zoonotic Dis. 2007;7:229-40 pubmed
    Prevalence of antibody reactive with Sin Nombre hantavirus (SNV) was evaluated from rodents captured over 31 months (March 1988 to September 1990) from six mark-recapture grids on the central Argentine Pampa...
  69. Safronetz D, Hegde N, Ebihara H, Denton M, Kobinger G, St Jeor S, et al. Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus. J Virol. 2009;83:7285-95 pubmed publisher
    ..humans following aerosolization from rodent feces and urine, producing hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Due to the high rates of mortality and lack of therapies, vaccines are urgently needed...
  70. Yashina L, Abramov S, Gutorov V, Dupal T, Krivopalov A, Panov V, et al. Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia. Vector Borne Zoonotic Dis. 2010;10:585-91 pubmed publisher
    ..captured in 11 localities in Western and Eastern Siberia during June 2007 to September 2008, were analyzed for hantavirus RNA by reverse transcription-polymerase chain reaction. Hantavirus L and S segment sequences, detected in 11 S...
  71. Zelena H, Zvolankova V, Zuchnicka J, Liszkova K, Papa A. Hantavirus infection during a stay in a mountain hut in Northern Slovakia. J Med Virol. 2011;83:496-500 pubmed publisher
    ..The two patients, combined with a third case observed in the same year in a nearby village in the Czech Republic, suggest that this region in Central Europe has to be considered as endemic for HFRS. ..
  72. Araujo J, Pereira A, Nardi M, Henriques D, Lautenschalager D, Dutra L, et al. Detection of hantaviruses in Brazilian rodents by SYBR-Green-based real-time RT-PCR. Arch Virol. 2011;156:1269-74 pubmed publisher
    Current knowledge of the pathogenic hantavirus indicates that wild rodents are its primary natural reservoir. Specific primers to detect the presence of viral genomes were developed using an SYBR-Green-based real-time RT-PCR protocol...
  73. Vaheri A, Henttonen H, Voutilainen L, Mustonen J, Sironen T, Vapalahti O. Hantavirus infections in Europe and their impact on public health. Rev Med Virol. 2013;23:35-49 pubmed publisher
    Hantaviruses (genus Hantavirus, family Bunyaviridae) are enveloped tri-segmented negative-stranded RNA viruses each carried by a specific rodent or insectivore host species...
  74. Fulhorst C, Milazzo M, Armstrong L, Childs J, Rollin P, Khabbaz R, et al. Hantavirus and arenavirus antibodies in persons with occupational rodent exposure. Emerg Infect Dis. 2007;13:532-8 pubmed
    Rodents are the principal hosts of Sin Nombre virus, 4 other hantaviruses known to cause hantavirus pulmonary syndrome in North America, and the 3 North American arenaviruses...
  75. Plyusnina A, Ibrahim I, Plyusnin A. A newly recognized hantavirus in the Asian house rat (Rattus tanezumi) in Indonesia. J Gen Virol. 2009;90:205-9 pubmed publisher
    ..Phylogenetic analysis of partial L, M and S segment sequences showed that they belonged to a novel hantavirus provisionally named Serang virus (SERV)...
  76. Henttonen H, Buchy P, Suputtamongkol Y, Jittapalapong S, Herbreteau V, Laakkonen J, et al. Recent discoveries of new hantaviruses widen their range and question their origins. Ann N Y Acad Sci. 2008;1149:84-9 pubmed publisher
    ..In addition, recent investigations in Cambodia revealed new Hantavirus types...
  77. Mertens M, Hofmann J, Petraityte Burneikiene R, Ziller M, Sasnauskas K, Friedrich R, et al. Seroprevalence study in forestry workers of a non-endemic region in eastern Germany reveals infections by Tula and Dobrava-Belgrade hantaviruses. Med Microbiol Immunol. 2011;200:263-8 pubmed publisher
    Highly endemic and outbreak regions for human hantavirus infections are located in the southern, southeastern, and western parts of Germany. The dominant hantavirus is the bank vole transmitted Puumala virus (PUUV)...
  78. Hepojoki J, Strandin T, Lankinen H, Vaheri A. Hantavirus structure--molecular interactions behind the scene. J Gen Virol. 2012;93:1631-44 pubmed publisher
    Viruses of the genus Hantavirus, carried and transmitted by rodents and insectivores, are the exception in the vector-borne virus family Bunyaviridae, since viruses of the other genera are transmitted via arthropods...
  79. Hartline J, Mierek C, Knutson T, Kang C. Hantavirus infection in North America: a clinical review. Am J Emerg Med. 2013;31:978-82 pubmed publisher
    The recent outbreak of hantavirus in Yosemite National Park has attracted national attention, with 10 confirmed cases of hantavirus cardiopulmonary syndrome and thousands of more people exposed...
  80. Jakab F, Horváth G, Ferenczi E, Sebok J, Varecza Z, Szucs G. Detection of Dobrava hantaviruses in Apodemus agrarius mice in the Transdanubian region of Hungary. Virus Res. 2007;128:149-52 pubmed
    Dobrava hantavirus (DOBV) belongs to the genus Hantavirus of the family Bunyaviridae, and is carried by yellow necked and striped field mice (Apodemus flavicollis and Apodemus agrarius), respectively...
  81. Schountz T, Prescott J, Cogswell A, Oko L, Mirowsky Garcia K, Galvez A, et al. Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus. Proc Natl Acad Sci U S A. 2007;104:15496-501 pubmed
    b>Hantavirus cardiopulmonary syndrome is a zoonotic illness associated with a systemic inflammatory immune response, capillary leak, noncardiogenic pulmonary edema, and shock in humans...
  82. Markotic A, Hensley L, Daddario K, Spik K, Anderson K, Schmaljohn C. Pathogenic hantaviruses elicit different immunoreactions in THP-1 cells and primary monocytes and induce differentiation of human monocytes to dendritic-like cells. Coll Antropol. 2007;31:1159-67 pubmed
    Hantaviruses cause two important human illnesses, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Both syndromes are believed to be immune-mediated diseases...
  83. Gledovic Z, Jeknic A, Grgurevic A, Rakocevic B, Bozovic B, Mugosa B. Hemorrhagic fever with renal syndrome in Montenegro. Jpn J Infect Dis. 2008;61:386-7 pubmed
    ..e., the yellow-neck mouse and the striped-field mouse. It is likely that HFRS in Montenegro will become more common in the near future, unless public health control measures are taken...
  84. Manigold T, Martinez J, Lazcano X, Ye C, Schwartz S, Cuiza A, et al. Case report: T-cell responses during clearance of Andes virus from blood cells 2 months after severe hantavirus cardiopulmonary syndrome. J Med Virol. 2008;80:1947-51 pubmed publisher
    b>Hantavirus Cardiopulmonary Syndrome (HCPS) due to Andes virus (ANDV) is endemic in Chile and Argentina and currently demonstrates a case-fatality rate of 37% in humans...
  85. Zhang Y, Lin X, Shi N, Wang W, Liao X, Guo W, et al. Hantaviruses in small mammals and humans in the coastal region of Zhejiang Province, China. J Med Virol. 2010;82:987-95 pubmed publisher
    ..A total of 461 rodents and 199 shrews were captured in these two areas. Hantavirus antibodies were detected in 16 of 241 (6.64%) Rattus norvegicus and 13 of 122 (10.66%) R. flavipectus...
  86. Guo W, Lin X, Wang W, Zhang X, Chen Y, Cao J, et al. A new subtype of Thottapalayam virus carried by the Asian house shrew (Suncus murinus) in China. Infect Genet Evol. 2011;11:1862-7 pubmed publisher
    Recently, many novel hantavirus species carried by insectivore had been found...
  87. Safronetz D, Haddock E, Feldmann F, Ebihara H, Feldmann H. In vitro and in vivo activity of ribavirin against Andes virus infection. PLoS ONE. 2011;6:e23560 pubmed publisher
    ..viruses which are responsible for two distinct diseases in humans, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome (HPS, otherwise known as hantavirus cardiopulmonary syndrome, HCPS)...
  88. Ferres M, Vial P, Marco C, Yanez L, Godoy P, Castillo C, et al. Prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in chile. J Infect Dis. 2007;195:1563-71 pubmed
    ..Andes virus (ANDV) infection, which has a case fatality rate of 37% in Chile, often occurs in household clusters and may be transmitted from person to person...
  89. Easterbrook J, Zink M, Klein S. Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host. Proc Natl Acad Sci U S A. 2007;104:15502-7 pubmed
    ..These data provide evidence of regulatory T cell involvement in the persistence of a zoonotic pathogen in its natural reservoir host. ..
  90. Kuenzi A, Morrison M, Madhav N, Mills J. Brush mouse (Peromyscus boylii) population dynamics and hantavirus infection during a warm, drought period in southern Arizona. J Wildl Dis. 2007;43:675-83 pubmed
    We monitored Limestone Canyon hantavirus (LSCV) antibody prevalence, host (brush mouse, Peromyscus boylii) abundance, and environmental variables (temperature and rainfall) in brush mice captured on three trapping webs in southern Arizona ..
  91. Kang H, Bennett S, Dizney L, Sumibcay L, Arai S, Ruedas L, et al. Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii). Virology. 2009;388:8-14 pubmed publisher
    A genetically distinct hantavirus, designated Oxbow virus (OXBV), was detected in tissues of an American shrew mole (Neurotrichus gibbsii), captured in Gresham, Oregon, in September 2003...
  92. Acuña R, Cifuentes Muñoz N, Márquez C, Bulling M, Klingstrom J, Mancini R, et al. Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles. J Virol. 2014;88:2344-8 pubmed publisher
    ..Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc envelope glycoproteins lead to their self-assembly into virus-like particles (VLPs) which were ..