lymphocytic choriomeningitis virus

Summary

Summary: The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.

Top Publications

  1. Milazzo M, Campbell G, Fulhorst C. Novel arenavirus infection in humans, United States. Emerg Infect Dis. 2011;17:1417-20 pubmed publisher
    Immunoglobulin G against Whitewater Arroyo virus or lymphocytic choriomeningitis virus was found in 41 (3.5%) of 1,185 persons in the United States who had acute central nervous system disease or undifferentiated febrile illnesses...
  2. Mackerness K, Cox M, Lilly L, Weaver C, Harrington L, Zajac A. Pronounced virus-dependent activation drives exhaustion but sustains IFN-? transcript levels. J Immunol. 2010;185:3643-51 pubmed publisher
    ..We show that virus-specific CD8 T cells clearly respond during the early stages of chronic lymphocytic choriomeningitis virus infection, and that this early T cell response is more pronounced than that initially observed in ..
  3. Zapata J, Pauza C, Djavani M, Rodas J, Moshkoff D, Bryant J, et al. Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. Antiviral Res. 2011;92:125-38 pubmed publisher
    Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human ..
  4. Martin V, Grande Pérez A, Domingo E. No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus. Virology. 2008;378:185-92 pubmed publisher
    ..We have used the Arenavirus lymphocytic choriomeningitis virus (LCMV) to explore whether treatment with the mutagenic base analogue 5-fluorouracil (FU) selected ..
  5. Coppieters K, Amirian N, von Herrath M. Intravital imaging of CTLs killing islet cells in diabetic mice. J Clin Invest. 2012;122:119-31 pubmed publisher
    ..Collectively, these data portray the kinetics of CTL homing to and between antigenic target sites as a stochastic process at the sub-organ level and argue against a dominant influence of chemotactic gradients. ..
  6. Ng C, Oldstone M. Infected CD8?- dendritic cells are the predominant source of IL-10 during establishment of persistent viral infection. Proc Natl Acad Sci U S A. 2012;109:14116-21 pubmed publisher
    ..Our findings further illuminate the contribution of DCs to the production of IL-10 and to viral persistence...
  7. Mueller S, Langley W, Li G, Garcia Sastre A, Webby R, Ahmed R. Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections. J Immunol. 2010;185:2182-90 pubmed publisher
    ..and functional qualities of these cells with memory T cells generated after systemic infection with lymphocytic choriomeningitis virus (LCMV)...
  8. Ganusov V, de Boer R. Estimating in vivo death rates of targets due to CD8 T-cell-mediated killing. J Virol. 2008;82:11749-57 pubmed publisher
    ..by cytotoxic T lymphocytes and memory CD8 T cells specific to NP396 and GP276 epitopes of lymphocytic choriomeningitis virus (LCMV) in the mouse spleen...
  9. Schmitz I, Schneider C, Fröhlich A, Frebel H, Christ D, Leonard W, et al. IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog. 2013;9:e1003362 pubmed publisher

More Information

Publications138 found, 100 shown here

  1. Araki K, Turner A, Shaffer V, Gangappa S, Keller S, Bachmann M, et al. mTOR regulates memory CD8 T-cell differentiation. Nature. 2009;460:108-12 pubmed publisher
    ..Treatment of mice with rapamycin following acute lymphocytic choriomeningitis virus infection enhanced not only the quantity but also the quality of virus-specific CD8 T cells...
  2. de la Torre J. Molecular and cell biology of the prototypic arenavirus LCMV: implications for understanding and combating hemorrhagic fever arenaviruses. Ann N Y Acad Sci. 2009;1171 Suppl 1:E57-64 pubmed publisher
    ..In addition, evidence indicates that the worldwide-distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen. Moreover, arenaviruses pose a biodefense threat...
  3. Bonthius D. Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. Semin Pediatr Neurol. 2012;19:89-95 pubmed publisher
    b>Lymphocytic choriomeningitis virus (LCMV) is an important cause of neurologic disease in humans. Carried and secreted principally by wild mice, LCMV covers a large geographic range and infects great numbers of people...
  4. Choo D, Murali Krishna K, Anita R, Ahmed R. Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help. J Immunol. 2010;185:3436-44 pubmed publisher
    ..To examine the dynamics of this cell turnover, we transferred lymphocytic choriomeningitis virus specific memory CD8 T cells into naive mice and analyzed their in vivo division kinetics ..
  5. Recher M, Lang K, Navarini A, Hunziker L, Lang P, Fink K, et al. Extralymphatic virus sanctuaries as a consequence of potent T-cell activation. Nat Med. 2007;13:1316-23 pubmed
    ..can support the functions of CD8(+) T cells against persistently infecting viruses such as murine lymphocytic choriomeningitis virus (LCMV), cytomegalovirus, hepatitis C virus and HIV...
  6. Lee A, Rojek J, Gundersen A, Stroher U, Juteau J, Vaillant A, et al. Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers. Virology. 2008;372:107-17 pubmed
    The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) represents a powerful experimental model for the study of the basic virology and pathogenesis of arenaviruses...
  7. Munitic I, Decaluwe H, Evaristo C, Lemos S, Wlodarczyk M, Worth A, et al. Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection. J Virol. 2009;83:11795-807 pubmed publisher
    ..we compared the functional properties of dominant and subdominant populations in the response to lymphocytic choriomeningitis virus (LCMV)...
  8. Wiesel M, Kratky W, Oxenius A. Type I IFN substitutes for T cell help during viral infections. J Immunol. 2011;186:754-63 pubmed publisher
    ..In this study, we compared CD8(+) T cell responses elicited by lymphocytic choriomeningitis virus infection, as prototype of a T cell help independent infection, with T cell help dependent CD8(+) T ..
  9. Igonet S, Vaney M, Vonrhein C, Vonhrein C, Bricogne G, Stura E, et al. X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation. Proc Natl Acad Sci U S A. 2011;108:19967-72 pubmed publisher
    ..We report here the crystal structure of the recombinant GP2 ectodomain of the lymphocytic choriomeningitis virus, the arenavirus type species, at 1.8-Å resolution...
  10. Jin H, Anderson A, Tan W, West E, Ha S, Araki K, et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A. 2010;107:14733-8 pubmed publisher
    ..In this study, we document coregulation of CD8 T cell exhaustion by Tim-3 and PD-1 during chronic lymphocytic choriomeningitis virus infection...
  11. Penaloza MacMaster P, Ur Rasheed A, Iyer S, Yagita H, Blazar B, Ahmed R. Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice. J Virol. 2011;85:6168-74 pubmed publisher
    ..We investigated the effect of a transient CD70 blockade during an acute or a chronic lymphocytic choriomeningitis virus (LCMV) infection in mice...
  12. Christensen J, Fenger C, Issazadeh Navikas S, Krug A, Liljestrøm P, Goriely S, et al. Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery. J Virol. 2012;86:7384-92 pubmed publisher
    ..activity of key genes encoding antiviral host factors in the CNS of mice infected with lymphocytic choriomeningitis virus (LCMV)...
  13. Rodrigo W, Ortiz Riaño E, Pythoud C, Kunz S, de la Torre J, Martinez Sobrido L. Arenavirus nucleoproteins prevent activation of nuclear factor kappa B. J Virol. 2012;86:8185-97 pubmed publisher
    ..We demonstrate in the accompanying paper that the prototype member in the family, lymphocytic choriomeningitis virus (LCMV), disables the host innate defense by interfering with type I interferon (IFN-I) production ..
  14. Lee L, Burke S, Montoya M, Borrow P. Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice. J Immunol. 2009;182:7178-89 pubmed publisher
    ..IFN production during virus persistence, we analyzed type 1 IFN production during acute and chronic lymphocytic choriomeningitis virus (LCMV) infection...
  15. Pythoud C, Rodrigo W, Pasqual G, Rothenberger S, Martinez Sobrido L, de la Torre J, et al. Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK?. J Virol. 2012;86:7728-38 pubmed publisher
    ..Consistent with previous studies, infection with the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) prevented phosphorylation of IRF3 in response to infection with Sendai virus, a strong ..
  16. Macal M, Lewis G, Kunz S, Flavell R, Harker J, Zuniga E. Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection. Cell Host Microbe. 2012;11:617-30 pubmed publisher
    ..We find that the Old World arenaviruses lymphocytic choriomeningitis virus clone 13 (LCMV Cl13) and Lassa virus bind pDCs to a greater extent than cDCs...
  17. Cervantes Barragan L, Lewis K, Firner S, Thiel V, Hugues S, Reith W, et al. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A. 2012;109:3012-7 pubmed publisher
    ..Furthermore, pDC-deficient animals failed to clear lymphocytic choriomeningitis virus (LCMV) from hematopoietic organs during persistent LCMV infection...
  18. Bonthius D, Perlman S. Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. PLoS Pathog. 2007;3:e149 pubmed
    ..The animal model for congenital lymphocytic choriomeningitis virus (LCMV) infection, however, does not suffer from this limitation. LCMV is a well-known human pathogen...
  19. Bonhomme C, Capul A, Lauron E, Bederka L, Knopp K, Buchmeier M. Glycosylation modulates arenavirus glycoprotein expression and function. Virology. 2011;409:223-33 pubmed publisher
    The glycoprotein of lymphocytic choriomeningitis virus (LCMV) contains nine potential N-linked glycosylation sites. We investigated the function of these N-glycosylations by using alanine-scanning mutagenesis...
  20. Diana J, Griseri T, Lagaye S, Beaudoin L, Autrusseau E, Gautron A, et al. NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner. Immunity. 2009;30:289-99 pubmed publisher
    ..Here, we showed that iNKT cells induced tissue-specific antiviral effects in mice infected by lymphocytic choriomeningitis virus (LCMV)...
  21. Yi J, Du M, Zajac A. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009;324:1572-6 pubmed publisher
    ..IL-21 regulates the development of CD8+ T cell exhaustion and the ability to contain chronic lymphocytic choriomeningitis virus infection...
  22. Quirin K, Eschli B, Scheu I, Poort L, Kartenbeck J, Helenius A. Lymphocytic choriomeningitis virus uses a novel endocytic pathway for infectious entry via late endosomes. Virology. 2008;378:21-33 pubmed publisher
    The endocytic entry of lymphocytic choriomeningitis virus (LCMV) into host cells was compared to the entry of viruses known to exploit clathrin or caveolae/raft-dependent pathways...
  23. Rutishauser R, Martins G, Kalachikov S, Chandele A, Parish I, Meffre E, et al. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity. 2009;31:296-308 pubmed publisher
    ..repressor Blimp-1 enhanced the formation of terminally differentiated CD8(+) T cells during lymphocytic choriomeningitis virus (LCMV) infection, and Blimp-1 deficiency promoted the acquisition of memory cell properties by ..
  24. Urata S, Yun N, Pasquato A, Paessler S, Kunz S, de la Torre J. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011;85:795-803 pubmed publisher
    ..PF-429242 efficiently prevented the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV, which correlated with the compound's potent antiviral activity against LCMV and ..
  25. Shedlock D, Talbott K, Cress C, Ferraro B, Tuyishme S, Mallilankaraman K, et al. A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge. Vaccine. 2011;29:6755-62 pubmed publisher
    ..We developed a highly optimized plasmid DNA vaccine that expresses the lymphocytic choriomeningitis virus (LCMV) nucleocapsid protein (NP) and evaluated it using the LCMV challenge model, a gold standard ..
  26. Wang Y, Swiecki M, Cella M, Alber G, Schreiber R, Gilfillan S, et al. Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection. Cell Host Microbe. 2012;11:631-42 pubmed publisher
    ..Using acute and chronic lymphocytic choriomeningitis virus (LCMV) infection models, we determined that pDCs transiently produce IFN-I that minimally impacts ..
  27. Iannacone M, Sitia G, Isogawa M, Whitmire J, Marchese P, Chisari F, et al. Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A. 2008;105:629-34 pubmed publisher
    We found that mice infected with different isolates of lymphocytic choriomeningitis virus (LCMV) develop a mild hemorrhagic anemia, which becomes severe and eventually lethal in animals depleted of platelets or lacking integrin beta3...
  28. Weant A, Michalek R, Khan I, Holbrook B, Willingham M, Grayson J. Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity. 2008;28:218-30 pubmed publisher
    ..When lymphocytic choriomeningitis virus (LCMV)-specific immune responses were quantitated, double-mutant mice had 100-fold more antigen-..
  29. Imperiali M, Spörri R, Hewitt J, Oxenius A. Post-translational modification of {alpha}-dystroglycan is not critical for lymphocytic choriomeningitis virus receptor function in vivo. J Gen Virol. 2008;89:2713-22 pubmed publisher
    ..alpha-DG) is a ubiquitously expressed molecule that has been identified as a cellular receptor for lymphocytic choriomeningitis virus (LCMV) and other arenaviruses...
  30. Sarkar S, Kalia V, Haining W, Konieczny B, Subramaniam S, Ahmed R. Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med. 2008;205:625-40 pubmed publisher
    ..These studies support the decreasing potential model of memory differentiation and show that the duration of antigenic stimulation is a critical regulator of memory formation. ..
  31. Intlekofer A, Banerjee A, Takemoto N, Gordon S, Dejong C, Shin H, et al. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science. 2008;321:408-11 pubmed publisher
    ..and eomesodermin (Eomes) fail to differentiate into functional killers required for defense against lymphocytic choriomeningitis virus. Instead, virus-specific CD8+ T cells lacking both T-bet and Eomes differentiate into an interleukin-..
  32. Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga E. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009;31:145-57 pubmed publisher
    ..Our findings reveal persisting TGF-beta-Smad signaling as a hallmark and key regulator of CD8(+) T cell responses during chronic viral infections in vivo. ..
  33. Martin V, Abia D, Domingo E, Grande Pérez A. An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis. J Gen Virol. 2010;91:990-1003 pubmed publisher
    ..studies have documented that, in the presence of the mutagenic base analogue 5-fluorouracil (FU), lymphocytic choriomeningitis virus (LCMV) that persisted in BHK-21 cells decreased its infectivity to a larger extent than ..
  34. Williams M, Ravkov E, Bevan M. Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity. 2008;28:533-45 pubmed publisher
    ..These results support a model in which CD4+ T cell memory differentiation and longevity depend on the strength of the TCR signal during the primary response. ..
  35. Hegazy A, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, et al. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity. 2010;32:116-28 pubmed publisher
    ..Here we show that infection with Th1 cell-promoting lymphocytic choriomeningitis virus (LCMV) reprogrammed otherwise stably committed GATA-3(+) Th2 cells to adopt a GATA-3(+)T-bet(+) and ..
  36. Kao C, Oestreich K, Paley M, Crawford A, Angelosanto J, Ali M, et al. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol. 2011;12:663-71 pubmed publisher
    ..Persistent antigenic stimulation caused downregulation of T-bet, which resulted in more severe exhaustion of CD8(+) T cells. Our observations suggest therapeutic opportunities involving higher T-bet expression during chronic infection...
  37. Wilson E, Yamada D, Elsaesser H, Herskovitz J, DENG J, Cheng G, et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science. 2013;340:202-7 pubmed publisher
    ..Thus, we demonstrated that interfering with chronic IFN-I signaling during persistent infection redirects the immune environment to enable control of infection...
  38. Shin H, Kapoor V, Guan T, Kaech S, Welsh R, Berg L. Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection. Immunity. 2013;39:661-75 pubmed publisher
    ..These data elucidate a central mechanism by which Blimp-1 acts as an epigenetic regulator and enhances the numbers of short-lived effector cells while suppressing the development of memory-precursor CD8? T cells. ..
  39. Wherry E, Ha S, Kaech S, Haining W, Sarkar S, Kalia V, et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007;27:670-84 pubmed
    ..the molecular signature of exhaustion, we compared the gene-expression profiles of dysfunctional lymphocytic choriomeningitis virus (LCMV)-specific CD8(+) T cells from chronic infection to functional LCMV-specific effector and ..
  40. Aneja R, Kalia V, Ahmed R, Joshi H. Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infection. Mol Cancer Ther. 2007;6:2891-9 pubmed
    ..mg/kg) does not suppress cell-mediated immune responses in mice experimentally challenged with acute lymphocytic choriomeningitis virus infection, in that mice mount robust virus-specific CD8(+) and CD4(+) T-cell immune responses while ..
  41. Yates A, Graw F, Barber D, Ahmed R, Regoes R, Antia R. Revisiting estimates of CTL killing rates in vivo. PLoS ONE. 2007;2:e1301 pubmed
    ..We reanalyse data previously used to estimate killing rates of CTL specific for two epitopes of lymphocytic choriomeningitis virus (LCMV) in mice and show that, contrary to previous estimates the "killing rate" of ..
  42. Waggoner S, Taniguchi R, Mathew P, Kumar V, Welsh R. Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis. J Clin Invest. 2010;120:1925-38 pubmed publisher
    ..We show here that persistent lymphocytic choriomeningitis virus (LCMV) infection of mice lacking 2B4 resulted in diminished LCMV-specific CD8+ T cell responses, ..
  43. Siddiqui S, Basta S. CD8+ T cell immunodominance in lymphocytic choriomeningitis virus infection is modified in the presence of toll-like receptor agonists. J Virol. 2011;85:13224-33 pubmed publisher
    ..that dual TLR2 plus TLR3 (designated TLR2+3) stimulation alters the immunodominance hierarchies of lymphocytic choriomeningitis virus (LCMV) epitopes by reducing NP396-specific CD8+ T cell responses and shifting it to a subdominant ..
  44. Wiesel M, Crouse J, Bedenikovic G, Sutherland A, Joller N, Oxenius A. Type-I IFN drives the differentiation of short-lived effector CD8+ T cells in vivo. Eur J Immunol. 2012;42:320-9 pubmed publisher
    ..We found that under priming conditions dominated by type-I IFN, as observed in lymphocytic choriomeningitis virus (LCMV) infection, type-I IFN signaling directly impacted the regulation of T-bet and thus the early ..
  45. Amanna I, Raué H, Slifka M. Development of a new hydrogen peroxide–based vaccine platform. Nat Med. 2012;18:974-9 pubmed publisher
    ..Mice immunized with H(2)O(2)-inactivated lymphocytic choriomeningitis virus (LCMV) generated cytolytic, multifunctional virus-specific CD8(+) T cells that conferred protection ..
  46. Capul A, de la Torre J. A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding. Virology. 2008;382:107-14 pubmed publisher
    ..In addition, compelling evidence indicates that the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance...
  47. Crawford A, Angelosanto J, Nadwodny K, Blackburn S, Wherry E. A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. PLoS Pathog. 2011;7:e1002098 pubmed publisher
    ..Our results demonstrate an important role for RANTES in sustaining CD8 T cell responses during a systemic chronic viral infection. ..
  48. Neuman B, Bederka L, Stein D, Ting J, Moulton H, Buchmeier M. Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors. Antimicrob Agents Chemother. 2011;55:4631-8 pubmed publisher
    ..of both genomic segments were effective against Junín virus, Tacaribe virus, Pichinde virus, and lymphocytic choriomeningitis virus (LCMV)-infected cell cultures and suppressed viral titers in the livers of LCMV-infected mice...
  49. West E, Youngblood B, Tan W, Jin H, Araki K, Alexe G, et al. Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity. 2011;35:285-98 pubmed publisher
    ..Herein, by comparing the responses of memory and naive CD8(+) T cells to acute and chronic lymphocytic choriomeningitis virus infection, we show that memory cells dominated over naive cells and were protective when present in ..
  50. Johnston R, Poholek A, DiToro D, Yusuf I, Eto D, Barnett B, et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 2009;325:1006-10 pubmed publisher
    ..These findings demonstrate that T(FH) cells are required for proper B cell responses in vivo and that Bcl6 and Blimp-1 play central but opposing roles in T(FH) differentiation. ..
  51. Christen U, Hintermann E, Holdener M, Von Herrath M. Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty?. J Autoimmun. 2010;34:38-44 pubmed publisher
    ..We focus on the RIP-LCMV model for type 1 diabetes and the novel cytochrome P450 2D6 (CYP2D6) model for autoimmune hepatitis, which use either identical or similar triggering and target antigens. ..
  52. Brooks D, Walsh K, Elsaesser H, Oldstone M. IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection. Proc Natl Acad Sci U S A. 2010;107:3018-23 pubmed publisher
    ..In response to lymphocytic choriomeningitis virus (LCMV) infection, the immunosuppressive cytokine IL-10 is rapidly up-regulated; however, how IL-10 ..
  53. Zhou S, Cerny A, Zacharia A, Fitzgerald K, Kurt Jones E, Finberg R. Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus. J Virol. 2010;84:9452-62 pubmed publisher
    Type I interferons (IFNs) play a critical role in the host defense against viruses. Lymphocytic choriomeningitis virus (LCMV) infection induces robust type I IFN production in its natural host, the mouse...
  54. Fahey L, Wilson E, Elsaesser H, Fistonich C, McGavern D, Brooks D. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med. 2011;208:987-99 pubmed publisher
    ..Importantly, this sustained CD4 T cell functionality is critical to maintain immunity and ultimately aid in the control of persistent viral infection. ..
  55. Charbonnel N, Deter J, Chaval Y, Laakkonen J, Henttonen H, Voutilainen L, et al. Serological evidence of viruses naturally associated with the montane water vole (Arvicola scherman) in eastern France. Vector Borne Zoonotic Dis. 2008;8:763-7 pubmed publisher
    ..terrestris, in eastern France for antibodies (immunoglobulin G) to Puumala virus (PUUV), lymphocytic choriomeningitis virus (LCMV), and cowpox virus (CPXV). Antibodies to PUUV were found in 9 (5...
  56. Zhou S, Cerny A, Fitzgerald K, Kurt Jones E, Finberg R. Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection. J Virol. 2012;86:11254-65 pubmed
    ..type I IFN signaling pathway, is essential for the type I IFN response to many viruses, including lymphocytic choriomeningitis virus (LCMV)...
  57. Macleod M, McKee A, Crawford F, White J, Kappler J, Marrack P. CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proc Natl Acad Sci U S A. 2008;105:14521-6 pubmed publisher
    ..Both these factors affected the low proliferation of the memory cells, because either exogenous IL-2 or inhibition of IFNgamma increased the proliferation of the memory cells...
  58. Kim J, Kang S, Dustin M, McGavern D. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 2009;457:191-5 pubmed publisher
    b>Lymphocytic choriomeningitis virus infection of the mouse central nervous system (CNS) elicits fatal immunopathology through blood-brain barrier breakdown and convulsive seizures...
  59. Mitchell D, Ravkov E, Williams M. Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells. J Immunol. 2010;184:6719-30 pubmed publisher
    ..These findings indicate a unique role for IL-2, but not IL-15, in promoting the differentiation not only of primary effector CD8+ T cells, but also of CD8+ memory T cells capable of secondary effector differentiation...
  60. Lang P, Lang K, Xu H, Grusdat M, Parish I, Recher M, et al. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A. 2012;109:1210-5 pubmed publisher
    ..killer (NK) cells have a negative impact on the development of T-cell immunity by using the murine lymphocytic choriomeningitis virus. NK cell-deficient (Nfil3(-/-), E4BP4(-/-)) mice exhibited a higher virus-specific T-cell response...
  61. Casey K, Fraser K, Schenkel J, Moran A, Abt M, Beura L, et al. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol. 2012;188:4866-75 pubmed publisher
  62. Kraft A, Wlodarczyk M, Kenney L, Selin L. PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. J Virol. 2013;87:12636-47 pubmed publisher
    Prior immunity to influenza A virus (IAV) in mice changes the outcome to a subsequent lymphocytic choriomeningitis virus (LCMV) infection and can result in severe lung pathology, similar to that observed in patients that died of the 1918 ..
  63. Emonet S, Garidou L, McGavern D, de la Torre J. Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest. Proc Natl Acad Sci U S A. 2009;106:3473-8 pubmed publisher
    ..However, the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) has proven to be a Rosetta stone for the investigation of virus-host interactions...
  64. Hofmann M, Pircher H. E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands. Proc Natl Acad Sci U S A. 2011;108:16741-6 pubmed publisher
    ..In mice immune to lymphocytic choriomeningitis virus (LCMV) or vesicular stomatitis virus(VSV), virus-specific memory CD8 T cells with this unusual ..
  65. Joeckel L, Wallich R, Metkar S, Froelich C, Simon M, Borner C. Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice. J Virol. 2012;86:8713-9 pubmed publisher
    The T cell granule exocytosis pathway is essential to control hepatotropic lymphocytic choriomeningitis virus strain WE (LCMV-WE) but also contributes to the observed pathology in mice...
  66. Hardy L, Wick D, Webb J. Conversion of tyrosine to the inflammation-associated analog 3'-nitrotyrosine at either TCR- or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8. J Immunol. 2008;180:5956-62 pubmed
    ..In this study, we used the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein (gp33) to demonstrate that conversion of tyrosine to nitrotyrosine can also profoundly ..
  67. Korns Johnson D, Homann D. Accelerated and improved quantification of lymphocytic choriomeningitis virus (LCMV) titers by flow cytometry. PLoS ONE. 2012;7:e37337 pubmed publisher
    b>Lymphocytic choriomeningitis virus (LCMV), a natural murine pathogen, is a member of the Arenavirus family, may cause atypical meningitis in humans, and has been utilized extensively as a model pathogen for the study of virus-induced ..
  68. Ha S, Mueller S, Wherry E, Barber D, Aubert R, Sharpe A, et al. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med. 2008;205:543-55 pubmed publisher
    ..functional CD8(+) T cell responses and improves viral control in mice chronically infected with lymphocytic choriomeningitis virus. This combinatorial therapeutic vaccination was effective even in the absence of CD4(+) T cell help...
  69. Al Zein N, Boyce T, Correa A, Rodriguez V. Meningitis caused by lymphocytic choriomeningitis virus in a patient with leukemia. J Pediatr Hematol Oncol. 2008;30:781-4 pubmed publisher
    ..Meningitis caused by lymphocytic choriomeningitis virus was identified serologically...
  70. Blackburn S, Shin H, Haining W, Zou T, Workman C, Polley A, et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol. 2009;10:29-37 pubmed publisher
    ..Thus, CD8+ T cell responses during chronic viral infections are regulated by complex patterns of coexpressed inhibitory receptors...
  71. Sullivan B, Emonet S, Welch M, Lee A, Campbell K, de la Torre J, et al. Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence. Proc Natl Acad Sci U S A. 2011;108:2969-74 pubmed publisher
    ..The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is widely used as a model system for studying persistent and acute infections, as well as for ..
  72. Popkin D, Teijaro J, Sullivan B, Urata S, Rutschmann S, de la Torre J, et al. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner. Cell Host Microbe. 2011;9:212-222 pubmed publisher
    The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV...
  73. Ortiz Riaño E, Cheng B, de la Torre J, Martinez Sobrido L. The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response. J Virol. 2011;85:13038-48 pubmed publisher
    ..In the present study, we have characterized the NP-Z interaction for the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)...
  74. Amoah S, Yammani R, Grayson J, Alexander Miller M. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol. 2012;189:638-45 pubmed publisher
    ..These results highlight the potential contribution of avidity in the differentiation and evolution of the T cell effector response after viral infection...
  75. Wieland S, Takahashi K, Boyd B, Whitten Bauer C, Ngo N, de La Torre J, et al. Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. J Virol. 2014;88:752-7 pubmed publisher
    ..that human pDCs are also activated by a TLR7-dependent, virus-independent, exosomal RNA transfer mechanism by human and mouse hepatoma and nonhepatoma cells that replicate the negative-strand lymphocytic choriomeningitis virus (LCMV).
  76. Hinson E, Joshi N, Chen J, Rahner C, Jung Y, Wang X, et al. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 2010;184:5723-31 pubmed publisher
    ..In this study, we analyzed viperin expression in vivo during acute lymphocytic choriomeningitis virus Armstrong infection, which induces high levels of type I IFNs, and in persistently infected ..
  77. Albarino C, Palacios G, Khristova M, Erickson B, Carroll S, Comer J, et al. High diversity and ancient common ancestry of lymphocytic choriomeningitis virus. Emerg Infect Dis. 2010;16:1093-100 pubmed publisher
    b>Lymphocytic choriomeningitis virus (LCMV) is the prototype of the family Arenaviridae...
  78. Singh A, Jatzek A, Plisch E, Srinivasan R, Svaren J, Suresh M. Regulation of memory CD8 T-cell differentiation by cyclin-dependent kinase inhibitor p27Kip1. Mol Cell Biol. 2010;30:5145-59 pubmed publisher
    ..These findings provide critical insights into the cell cycle regulation of CD8 T-cell homeostasis and suggest that modulation of p27(Kip1) could bolster vaccine-induced T-cell memory and protective immunity...
  79. Araki K, Gangappa S, Dillehay D, Rouse B, Larsen C, Ahmed R. Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation. J Exp Med. 2010;207:2355-67 pubmed publisher
    Recently, several cases of fatal lymphocytic choriomeningitis virus (LCMV) infection occurred in transplant recipients being treated with the immunosuppressive calcineurin inhibitor FK506...
  80. Emonet S, Urata S, de la Torre J. Arenavirus reverse genetics: new approaches for the investigation of arenavirus biology and development of antiviral strategies. Virology. 2011;411:416-25 pubmed publisher
  81. Christen S, Holdener M, Beerli C, Thoma G, Bayer M, Pfeilschifter J, et al. Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model. Clin Exp Immunol. 2011;165:318-28 pubmed publisher
  82. Norris B, Uebelhoer L, Nakaya H, Price A, Grakoui A, Pulendran B. Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity. 2013;38:309-21 pubmed publisher
    ..Here we report that infection with acute Armstrong (ARM) or chronic Clone 13 (C13) strains of lymphocytic choriomeningitis virus (LCMV) led to two distinct phases of innate immune response...
  83. Scandella E, Bolinger B, Lattmann E, Miller S, Favre S, Littman D, et al. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat Immunol. 2008;9:667-75 pubmed publisher
    ..We show here that during acute infection with lymphocytic choriomeningitis virus, antiviral cytotoxic T cells destroyed infected T cell zone stromal cells, which led to profound ..
  84. Bergthaler A, Flatz L, Verschoor A, Hegazy A, Holdener M, Fink K, et al. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol. 2009;7:e1000080 pubmed publisher
    ..Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection...
  85. Cordey S, Sahli R, Moraz M, Estrade C, Morandi L, Cherpillod P, et al. Analytical validation of a lymphocytic choriomeningitis virus real-time RT-PCR assay. J Virol Methods. 2011;177:118-22 pubmed publisher
    b>Lymphocytic choriomeningitis virus (LCMV) is a rare cause of central nervous system disease in humans. Screening by real-time RT-PCR assay is of interest in the case of aseptic meningitis of unknown etiology...
  86. Waggoner S, Cornberg M, Selin L, Welsh R. Natural killer cells act as rheostats modulating antiviral T cells. Nature. 2011;481:394-8 pubmed publisher
    ..In contrast to MCMV, lymphocytic choriomeningitis virus (LCMV) infection in mice seems to be resistant to any direct antiviral effects of NK cells...
  87. Shimojima M, Kawaoka Y. Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein. J Vet Med Sci. 2012;74:1363-6 pubmed
    The glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, is a promising envelope protein of lentiviral pseudotype vectors for gene therapy...
  88. Brooks D, Lee A, Elsaesser H, McGavern D, Oldstone M. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J Exp Med. 2008;205:533-41 pubmed publisher
    ..interleukin (IL)-10 stimulated T cell responses and improved control of established persistent lymphocytic choriomeningitis virus (LCMV) infection...
  89. Rahman A, Cui W, LaRosa D, Taylor D, Zhang J, Goldstein D, et al. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. J Immunol. 2008;181:3804-10 pubmed
    During acute lymphocytic choriomeningitis virus (LCMV) infection, CD8 T cells rapidly expand and differentiate into effectors that are required for viral clearance...
  90. Blattman J, Wherry E, Ha S, van der Most R, Ahmed R. Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J Virol. 2009;83:4386-94 pubmed publisher
    ..Here, we tracked the fate of virus-specific CD8 T cells in lymphocytic choriomeningitis virus (LCMV)-infected mice during viral clearance, the persistence of wild-type virus, or the selection ..
  91. Tagliapietra V, Rosa R, Hauffe H, Laakkonen J, Voutilainen L, Vapalahti O, et al. Spatial and temporal dynamics of lymphocytic choriomeningitis virus in wild rodents, northern Italy. Emerg Infect Dis. 2009;15:1019-25 pubmed publisher
    We determined the prevalence of infection with lymphocytic choriomeningitis virus (LCMV) among small mammals in northern Italy and analyzed long-term dynamics of LCMV in a rodent population in the province of Trento...
  92. Bergthaler A, Flatz L, Hegazy A, Johnson S, Horvath E, Löhning M, et al. Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proc Natl Acad Sci U S A. 2010;107:21641-6 pubmed publisher
    The Clone 13 (Cl13) strain of lymphocytic choriomeningitis virus is widely studied as a model of chronic systemic viral infection...