arenavirus

Summary

Summary: The only genus in the family ARENAVIRIDAE. It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution.

Top Publications

  1. Gonzalez J, Emonet S, De Lamballerie X, Charrel R. Arenaviruses. Curr Top Microbiol Immunol. 2007;315:253-88 pubmed
    ..Recombination and co-evolutionary adaptation appear as the main mechanisms of arenavirus evolution, generating a high degree of diversity...
  2. Klaus J, Eisenhauer P, Russo J, Mason A, Do D, King B, et al. The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles. Cell Host Microbe. 2013;14:522-34 pubmed publisher
    ..We identified human proteins that interact with the glycoproteins (GPs) of a prototypic arenavirus and hantavirus and show that the lectin endoplasmic reticulum (ER)-Golgi intermediate compartment 53 kDa protein ..
  3. Tortorici M, Albarino C, Posik D, Ghiringhelli P, Lozano M, Rivera Pomar R, et al. Arenavirus nucleocapsid protein displays a transcriptional antitermination activity in vivo. Virus Res. 2001;73:41-55 pubmed
    RNA polymerase pausing and transcriptional antitermination regulates gene activity in several systems. In arenavirus infected cells the switch from transcription to replication is subjected to a hairpin-dependent termination and requires ..
  4. Archer A, Rico Hesse R. High genetic divergence and recombination in Arenaviruses from the Americas. Virology. 2002;304:274-81 pubmed
    ..The results imply that arenaviruses have been evolving independently for a very long time, leading to very diverse groupings that do not correlate with geography, rodent host, or human epidemic potential...
  5. Charrel R, De Lamballerie X. Zoonotic aspects of arenavirus infections. Vet Microbiol. 2010;140:213-20 pubmed publisher
    ..International Committee for Taxonomy of Viruses recognizes that the family Arenaviridae contains a unique genus Arenavirus that includes 22 viral species...
  6. Pasquato A, Burri D, Traba E, Hanna El Daher L, Seidah N, Kunz S. Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease. Virology. 2011;417:18-26 pubmed publisher
    A crucial step in the arenavirus life cycle is the proteolytic processing of the viral envelope glycoprotein precursor (GPC) by the cellular proprotein convertase (PC) subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P)...
  7. Hall W, Geisbert T, Huggins J, Jahrling P. Experimental infection of guinea pigs with Venezuelan hemorrhagic fever virus (Guanarito): a model of human disease. Am J Trop Med Hyg. 1996;55:81-8 pubmed
    Venezuelan hemorrhagic fever (VHF), a newly described disease caused by an arenavirus (Guanarito), has resulted in multiple human deaths in Venezuela...
  8. Vela E, Colpitts T, Zhang L, Davey R, Aronson J. Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes. Arch Virol. 2008;153:1391-6 pubmed publisher
    Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway...
  9. Capul A, Perez M, Burke E, Kunz S, Buchmeier M, de la Torre J. Arenavirus Z-glycoprotein association requires Z myristoylation but not functional RING or late domains. J Virol. 2007;81:9451-60 pubmed
    Generation of infectious arenavirus-like particles requires the virus RING finger Z protein and surface glycoprotein precursor (GPC) and the correct processing of GPC into GP1, GP2, and a stable signal peptide (SSP)...

More Information

Publications86

  1. Oldstone M, Lewicki H, Homann D, Nguyen C, Julien S, Gairin J. Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses. J Virol. 2001;75:6273-8 pubmed
    ..NP 118-126 of the Old World arenaviruses LFV, Mopeia virus, and LCMV and the New World arenavirus Sabia virus bound at high affinity to L(d)...
  2. Charrel R, Coutard B, Baronti C, Canard B, Nougairede A, Frangeul A, et al. Arenaviruses and hantaviruses: from epidemiology and genomics to antivirals. Antiviral Res. 2011;90:102-14 pubmed publisher
  3. Lee A, Pasquato A, Kunz S. Novel approaches in anti-arenaviral drug development. Virology. 2011;411:163-9 pubmed publisher
    ..Over the past years significant efforts have been undertaken to identify novel potent inhibitors of arenavirus infection...
  4. Lopez N, Franze Fernandez M. A single stem-loop structure in Tacaribe arenavirus intergenic region is essential for transcription termination but is not required for a correct initiation of transcription and replication. Virus Res. 2007;124:237-44 pubmed
  5. Gowen B, Holbrook M. Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses. Antiviral Res. 2008;78:79-90 pubmed
    ..Such models are sufficient for testing of drugs that directly block viral replication, but may be inadequate for evaluating therapies that depend for their success on the activation or inhibition of host responses...
  6. Fulhorst C, Bennett S, Milazzo M, Murray H, Webb J, Cajimat M, et al. Bear Canyon virus: an arenavirus naturally associated with the California mouse (Peromyscus californicus). Emerg Infect Dis. 2002;8:717-21 pubmed
    ..An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents...
  7. Gonzalez J, Sanchez A, Rico Hesse R. Molecular phylogeny of Guanarito virus, an emerging arenavirus affecting humans. Am J Trop Med Hyg. 1995;53:1-6 pubmed
    ..of the N gene open reading frame showed that Guanarito virus is genetically distinct from other members of the Arenavirus family, with 32% nucleotide sequence divergence from Junin, 30% from Machupo, 32% from Tacaribe, 41% from ..
  8. Sevilla N, de La Torre J. Arenavirus diversity and evolution: quasispecies in vivo. Curr Top Microbiol Immunol. 2006;299:315-35 pubmed
    ..in biological properties observed among lymphocytic choriomeningitis virus (LCMV) strains, the prototypic arenavirus, indicates to what extent a quasis-pecies dynamics may play a role in arenavirus adaptability and pathogenesis...
  9. Andrei G, De Clercq E. Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993;22:45-75 pubmed
    ..togavirus (Chikungunya), flavivirus (dengue, yellow fever, Kyasanur Forest disease, Omsk hemorrhagic fever), arenavirus (Argentinian hemorrhagic fever, Bolivian hemorrhagic fever, Lassa fever), filovirus (Ebola, Marburg), ..
  10. Pasqual G, Burri D, Pasquato A, de la Torre J, Kunz S. Role of the host cell's unfolded protein response in arenavirus infection. J Virol. 2011;85:1662-70 pubmed publisher
    ..Here, we investigated the role of the host cell's unfolded protein response (UPR) in infection of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)...
  11. Damonte E, Coto C. Treatment of arenavirus infections: from basic studies to the challenge of antiviral therapy. Adv Virus Res. 2002;58:125-55 pubmed
  12. Eichler R, Strecker T, Kolesnikova L, Ter Meulen J, Weissenhorn W, Becker S, et al. Characterization of the Lassa virus matrix protein Z: electron microscopic study of virus-like particles and interaction with the nucleoprotein (NP). Virus Res. 2004;100:249-55 pubmed
    ..We assume that Z recruits NP to cellular membranes where virus assembly takes place. We conclude from our data that Lassa virus Z protein plays an essential role in Lassa virus maturation...
  13. Muller R, Poch O, Delarue M, Bishop D, Bouloy M. Rift Valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases. J Gen Virol. 1994;75 ( Pt 6):1345-52 pubmed
  14. Candurra N, Maskin L, Damonte E. Inhibition of arenavirus multiplication in vitro by phenotiazines. Antiviral Res. 1996;31:149-58 pubmed
    ..These data indicate that TFP and CPZ inhibit JV replication in vitro. Our findings suggest that the integrity of the actin microfilaments may be required for optimal arenavirus multiplication.
  15. Cao W, Henry M, Borrow P, Yamada H, Elder J, Ravkov E, et al. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science. 1998;282:2079-81 pubmed
    ..Thus, alpha-DG is a cellular receptor for both LCMV and LFV. ..
  16. Fritz C, Fulhorst C, Enge B, Winthrop K, Glaser C, Vugia D. Exposure to rodents and rodent-borne viruses among persons with elevated occupational risk. J Occup Environ Med. 2002;44:962-7 pubmed
    ..Nombre virus (SNV), the agent of hantavirus pulmonary syndrome, and Whitewater Arroyo virus (WWA), a New World arenavirus. Eighty-one persons with possible occupational exposure to rodents completed questionnaires and provided ..
  17. Rojek J, Pasqual G, Sanchez A, Nguyen N, de la Torre J, Kunz S. Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses. J Virol. 2010;84:573-84 pubmed publisher
    A crucial step in the arenavirus life cycle is the biosynthesis of the viral envelope glycoprotein (GP) responsible for virus attachment and entry...
  18. Lee A, Rojek J, Spiropoulou C, Gundersen A, Jin W, Shaginian A, et al. Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. J Biol Chem. 2008;283:18734-42 pubmed publisher
    ..we used high throughput screening of synthetic combinatorial small molecule libraries to identify inhibitors of arenavirus infection using pseudotyped virion particles bearing the glycoproteins (GPs) of highly pathogenic arenaviruses...
  19. Blasdell K, Becker S, Hurst J, Begon M, Bennett M. Host range and genetic diversity of arenaviruses in rodents, United Kingdom. Emerg Infect Dis. 2008;14:1455-8 pubmed publisher
    ..All sequences most closely resembled those of previously identified lymphocytic choriomeningitis virus...
  20. Loureiro M, Wilda M, Levingston Macleod J, D Antuono A, Foscaldi S, Marino Buslje C, et al. Molecular determinants of arenavirus Z protein homo-oligomerization and L polymerase binding. J Virol. 2011;85:12304-14 pubmed publisher
    The arenavirus Z is a zinc-binding RING protein that has been implicated in multiple functions during the viral life cycle. These roles of Z involve interactions with viral and cellular proteins that remain incompletely understood...
  21. Cajimat M, Milazzo M, Hess B, Rood M, Fulhorst C. Principal host relationships and evolutionary history of the North American arenaviruses. Virology. 2007;367:235-43 pubmed publisher
  22. Fulhorst C, Milazzo M, Armstrong L, Childs J, Rollin P, Khabbaz R, et al. Hantavirus and arenavirus antibodies in persons with occupational rodent exposure. Emerg Infect Dis. 2007;13:532-8 pubmed
    ..These results suggest that risk for infection with hantaviruses or arenaviruses usually is low in persons whose occupations entail close physical contact with neotomine or sigmodontine rodents in North America...
  23. Kallio Kokko H, Laakkonen J, Rizzoli A, Tagliapietra V, Cattadori I, Perkins S, et al. Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy. Epidemiol Infect. 2006;134:830-6 pubmed
    The spatial and temporal distribution of hantavirus and arenavirus antibody-positive wild rodents in Trentino, Italy, was studied using immunofluorescence assays (IFA) in two long-term sites trapped in 2000-2003, and six other sites ..
  24. Meulen J, Badusche M, Satoguina J, Strecker T, Lenz O, Loeliger C, et al. Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T-cell clones. Virology. 2004;321:134-43 pubmed
    ..Peptides with conservative aa exchanges, as they naturally occur in the epitope 289-301 of the Old World arenavirus Mopeia and some New World arenaviruses, continued to effectively stimulate the Lassa-GP2-specific T-cell clones ..
  25. Oldstone M. Arenaviruses. II. The molecular pathogenesis of arenavirus infections. Introduction. Curr Top Microbiol Immunol. 2002;263:V-XII pubmed
  26. Fulhorst C, Milazzo M, Bradley R, Peppers L. Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae). Am J Trop Med Hyg. 2001;65:147-51 pubmed
    The Whitewater Arroyo virus (WWA) is a newly described North American arenavirus. The purpose of this study was to elucidate the biology of this virus in its natural rodent host, Neotoma albigula (white-throated woodrat)...
  27. Wang J, Danzy S, Kumar N, Ly H, Liang Y. Biological roles and functional mechanisms of arenavirus Z protein in viral replication. J Virol. 2012;86:9794-801 pubmed publisher
    ..By taking advantage of the available reverse genetics system for a model arenavirus, Pichinde virus (PICV), we provide the direct evidence for the essential biological roles of the Z protein's ..
  28. Moreno H, Gallego I, Sevilla N, de la Torre J, Domingo E, Martin V. Ribavirin can be mutagenic for arenaviruses. J Virol. 2011;85:7246-55 pubmed publisher
    ..1-?-d-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide) is the only antiviral treatment currently available for arenavirus infections. However, the ribavirin antiviral mechanism action against arenaviruses remains unknown...
  29. de la Torre J. Arenavirus extinction through lethal mutagenesis. Virus Res. 2005;107:207-14 pubmed
    ..the importance of developing novel effective antiviral drugs to combat HF arenaviruses, for which the prototypic Arenavirus lymphocytic choriomeningitis virus (LCMV) provides us with an excellent model system...
  30. G nther S, Hoofd G, Charrel R, R ser C, Becker Ziaja B, Lloyd G, et al. Mopeia virus-related arenavirus in natal multimammate mice, Morogoro, Tanzania. Emerg Infect Dis. 2009;15:2008-12 pubmed publisher
    A serosurvey involving 2,520 small mammals from Tanzania identified a hot spot of arenavirus circulation in Morogoro...
  31. Fulhorst C, Bowen M, Salas R, Duno G, Utrera A, Ksiazek T, et al. Natural rodent host associations of Guanarito and pirital viruses (Family Arenaviridae) in central Venezuela. Am J Trop Med Hyg. 1999;61:325-30 pubmed
    ..Ninety-two arenavirus isolates from 607 animals, representing 10 different rodent species, were characterized to the level of serotype...
  32. Larson R, Dai D, Hosack V, Tan Y, Bolken T, Hruby D, et al. Identification of a broad-spectrum arenavirus entry inhibitor. J Virol. 2008;82:10768-75 pubmed publisher
    ..6 nM against LASV pseudotypes. ST-193 inhibited pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC(50)s for Junín, ..
  33. Palacios G, Druce J, Du L, Tran T, Birch C, Briese T, et al. A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med. 2008;358:991-8 pubmed publisher
    ..Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative...
  34. Neuman B, Bederka L, Stein D, Ting J, Moulton H, Buchmeier M. Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors. Antimicrob Agents Chemother. 2011;55:4631-8 pubmed publisher
    ..phosphorodiamidate morpholino oligomers (PPMO) complementary to viral genomic RNA were effective in reducing arenavirus replication in cell cultures and in vivo...
  35. Borremans B, Leirs H, Gryseels S, Gunther S, Makundi R, de Bellocq J. Presence of Mopeia virus, an African arenavirus, related to biotope and individual rodent host characteristics: implications for virus transmission. Vector Borne Zoonotic Dis. 2011;11:1125-31 pubmed publisher
    The East African Mopeia virus (MOPV) is an arenavirus closely related to the highly pathogenic West African Lassa virus, even sharing the same reservoir rodent host Mastomys natalensis...
  36. Botten J, Sidney J, Mothe B, Peters B, Sette A, Kotturi M. Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system. Microbiol Mol Biol Rev. 2010;74:157-70 pubmed publisher
    ..There are currently no FDA-approved vaccines for the prevention of arenavirus disease, and therapeutic treatment is limited to the use of ribavirin and/or immune plasma for a subset of the ..
  37. de Bellocq J, Borremans B, Katakweba A, Makundi R, Baird S, Becker Ziaja B, et al. Sympatric occurrence of 3 arenaviruses, Tanzania. Emerg Infect Dis. 2010;16:692-5 pubmed publisher
    ..We found that 2 rodent species other than Mastomys natalensis mice carry arenaviruses. Analysis of 340 nt of the viral RNA polymerase gene showed sympatric occurrence of 3 distinct arenaviruses...
  38. Parisi G, Echave J, Ghiringhelli D, Romanowski V. Computational characterisation of potential RNA-binding sites in arenavirus nucleocapsid proteins. Virus Genes. 1996;13:247-54 pubmed
    ..The middle-region has a slight homology to the nucleolar protein Fibrillarin containing an atypical RNP-1 conserved octamer. Finally, the carboxyl-terminal region has a putative zinc-finger...
  39. Moncayo A, Hice C, Watts D, Travassos de Rosa A, Guzman H, Russell K, et al. Allpahuayo virus: a newly recognized arenavirus (arenaviridae) from arboreal rice rats (oecomys bicolor and oecomys paricola) in northeastern peru. Virology. 2001;284:277-86 pubmed publisher
    ..Serological and genetic studies identified the virus as a new member of the Tacaribe complex of the genus Arenavirus. The small (S) segment of the Allpahuayo virus prototype strain CLHP-2098 (Accession No...
  40. Garbutt M, Liebscher R, Wahl Jensen V, Jones S, Möller P, Wagner R, et al. Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses. J Virol. 2004;78:5458-65 pubmed
    ..Our data suggest that the recombinant VSV can be used to study the role of the viral glycoproteins in virus replication, immune response, and pathogenesis...
  41. Jay M, Glaser C, Fulhorst C. The arenaviruses. J Am Vet Med Assoc. 2005;227:904-15 pubmed
  42. Bennett S, Milazzo M, Webb J, Fulhorst C. Arenavirus antibody in rodents indigenous to coastal southern California. Am J Trop Med Hyg. 2000;62:626-30 pubmed
  43. Urata S, Ngo N, de la Torre J. The PI3K/Akt pathway contributes to arenavirus budding. J Virol. 2012;86:4578-85 pubmed publisher
    ..On the other hand, evidence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen...
  44. Fulhorst C, Charrel R, Weaver S, Ksiazek T, Bradley R, Milazzo M, et al. Geographic distribution and genetic diversity of Whitewater Arroyo virus in the southwestern United States. Emerg Infect Dis. 2001;7:403-7 pubmed
    The purpose of this study was to extend our knowledge of the geographic distribution and genetic diversity of the arenavirus(es) associated with Neotoma species (woodrats) in the southwestern United States...
  45. Kentsis A, Dwyer E, Perez J, Sharma M, Chen A, Pan Z, et al. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. J Mol Biol. 2001;312:609-23 pubmed
    ..Here, we observe that PML and arenavirus protein Z use regions around the first zinc-binding site of their respective RING domains to directly interact, ..
  46. Kosoy M, Elliott L, Ksiazek T, Fulhorst C, Rollin P, Childs J, et al. Prevalence of antibodies to arenaviruses in rodents from the southern and western United States: evidence for an arenavirus associated with the genus Neotoma. Am J Trop Med Hyg. 1996;54:570-6 pubmed
    ..Antibody to at least one arenavirus was found in 220 (3.1%) of 7,106 rodents tested...
  47. Gallaher W, DiSimone C, Buchmeier M. The viral transmembrane superfamily: possible divergence of Arenavirus and Filovirus glycoproteins from a common RNA virus ancestor. BMC Microbiol. 2001;1:1 pubmed
  48. Lozano M, Posik D, Albarino C, Schujman G, Ghiringhelli P, Calderon G, et al. Characterization of arenaviruses using a family-specific primer set for RT-PCR amplification and RFLP analysis. Its potential use for detection of uncharacterized arenaviruses. Virus Res. 1997;49:79-89 pubmed
    ..A sequence alignment analysis of all reported arenavirus S RNAs yielded 17 conserved regions in addition to a reported conserved region at the end of both RNAs...
  49. Zapata J, Salvato M. Arenavirus variations due to host-specific adaptation. Viruses. 2013;5:241-78 pubmed publisher
    b>Arenavirus particles are enveloped and contain two single-strand RNA genomic segments with ambisense coding...
  50. Burri D, Pasqual G, Rochat C, Seidah N, Pasquato A, Kunz S. Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. J Virol. 2012;86:4935-46 pubmed publisher
    ..The maturation of the arenavirus GP precursor (GPC) critically depends on proteolytic processing by the cellular proprotein convertase (PC) ..
  51. Moraz M, Kunz S. Pathogenesis of arenavirus hemorrhagic fevers. Expert Rev Anti Infect Ther. 2011;9:49-59 pubmed publisher
    ..b>Arenavirus VHFs in humans are acute diseases characterized by fever and, in severe cases, different degrees of hemorrhages ..
  52. Fulhorst C, Bowen M, Salas R, De Manzione N, Duno G, Utrera A, et al. Isolation and characterization of pirital virus, a newly discovered South American arenavirus. Am J Trop Med Hyg. 1997;56:548-53 pubmed
    ..A previous study on the epidemiology of Venezuelan hemorrhagic fever revealed extensive arenavirus infection (presumed to be caused by Guanarito virus) in two rodent species...
  53. Agnihothram S, Dancho B, Grant K, Grimes M, Lyles D, Nunberg J. Assembly of arenavirus envelope glycoprotein GPC in detergent-soluble membrane microdomains. J Virol. 2009;83:9890-900 pubmed publisher
    ..Genetic diversity among arenavirus species in their respective rodent hosts supports the continued emergence of new pathogens...
  54. Marq J, Kolakofsky D, Garcin D. Unpaired 5' ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I. J Biol Chem. 2010;285:18208-16 pubmed publisher
    b>Arenavirus and bunyavirus RNA genomes are unusual in that they are found in circular nucleocapsids, presumably due to the annealing of their complementary terminal sequences...
  55. Bird B, Dodd K, Erickson B, Albarino C, Chakrabarti A, McMullan L, et al. Severe hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virus. PLoS Negl Trop Dis. 2012;6:e1801 pubmed publisher
    ..Establishing an animal LUJV model is an important first step towards understanding the high pathogenicity of LUJV and developing vaccines and antiviral therapeutic drugs for this highly transmissible and lethal emerging pathogen...
  56. Stenglein M, Sanders C, Kistler A, Ruby J, Franco J, Reavill D, et al. Identification, characterization, and in vitro culture of highly divergent arenaviruses from boa constrictors and annulated tree boas: candidate etiological agents for snake inclusion body disease. MBio. 2012;3:e00180-12 pubmed publisher
    ..and de novo assembled the complete genomic sequences of two viruses related to arenaviruses, and a third arenavirus-like sequence was discovered by screening an additional set of samples...
  57. Fulhorst C, Milazzo M, Carroll D, Charrel R, Bradley R. Natural host relationships and genetic diversity of Whitewater Arroyo virus in southern Texas. Am J Trop Med Hyg. 2002;67:114-8 pubmed
    ..captured in July 1999 on the Chaparral Wildlife Management Area in southern Texas and tested for evidence of arenavirus infection. Antibody to an arenavirus was found in seven (21...
  58. Messina E, York J, Nunberg J. Dissection of the role of the stable signal peptide of the arenavirus envelope glycoprotein in membrane fusion. J Virol. 2012;86:6138-45 pubmed publisher
    The arenavirus envelope glycoprotein (GPC) retains a stable signal peptide (SSP) as an essential subunit in the mature complex...
  59. Emonet S, de la Torre J, Domingo E, Sevilla N. Arenavirus genetic diversity and its biological implications. Infect Genet Evol. 2009;9:417-29 pubmed publisher
    ..with the cellular receptor and subsequent entry into the host cell differs between Old World and New World arenavirus that use alpha-dystoglycan or human transferring receptor 1, respectively, as main receptors...
  60. Paweska J, Sewlall N, Ksiazek T, Blumberg L, Hale M, Lipkin W, et al. Nosocomial outbreak of novel arenavirus infection, southern Africa. Emerg Infect Dis. 2009;15:1598-602 pubmed publisher
    ..Three cases involved secondary spread of infection from the first patient, and 1 was a tertiary infection. A novel arenavirus was identified. The source of the first patient's infection remains undetermined.
  61. Fulhorst C, Bowen M, Ksiazek T, Rollin P, Nichol S, Kosoy M, et al. Isolation and characterization of Whitewater Arroyo virus, a novel North American arenavirus. Virology. 1996;224:114-20 pubmed
    ..Prior to the present study, Tamiami (TAM) virus was the sole arenavirus known to be indigenous to North America; it has been isolated only from southern Florida where its primary host ..
  62. Grande Pérez A, Sierra S, Castro M, Domingo E, Lowenstein P. Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Proc Natl Acad Sci U S A. 2002;99:12938-43 pubmed
    ..Here we report that lymphocytic choriomeningitis virus, the prototype arenavirus, is extremely susceptible to extinction mutagenesis by the base analog 5-fluorouracil...
  63. Coulibaly N Golo D, Allali B, Kouassi S, Fichet Calvet E, Becker Ziaja B, Rieger T, et al. Novel arenavirus sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: implications for evolution of arenaviruses in Africa. PLoS ONE. 2011;6:e20893 pubmed publisher
    ..Specimens were screened by pan-Old World arenavirus RT-PCRs targeting S and L RNA segments as well as immunofluorescence assay...
  64. Rojek J, Kunz S. Cell entry by human pathogenic arenaviruses. Cell Microbiol. 2008;10:828-35 pubmed publisher
    ..While the New World arenavirus JUNV enters cells via clathrin-dependent endocytosis, evidence occurred for clathrin-independent entry of the ..
  65. Neuman B, Adair B, Burns J, Milligan R, Buchmeier M, Yeager M. Complementarity in the supramolecular design of arenaviruses and retroviruses revealed by electron cryomicroscopy and image analysis. J Virol. 2005;79:3822-30 pubmed
    ..The structural proteins of retroviruses and arenaviruses assemble with similar radial density distributions, using common cellular components...
  66. Calisher C, Nabity S, Root J, Fulhorst C, Beaty B. Transmission of an arenavirus in white-throated woodrats (Neotoma albigula), southeastern Colorado, 1995-1999. Emerg Infect Dis. 2001;7:397-402 pubmed
    ..Our findings will lead to better assessment of the public health threat posed by infected woodrats and may be useful in predicting periods of increased risk for human infection...
  67. Perez M, Craven R, de la Torre J. The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies. Proc Natl Acad Sci U S A. 2003;100:12978-83 pubmed
    By using a reverse genetics system that is based on the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), we have identified the arenavirus small RING finger Z protein as the main driving force of virus budding...
  68. Levingston Macleod J, D Antuono A, Loureiro M, Casabona J, Gomez G, Lopez N. Identification of two functional domains within the arenavirus nucleoprotein. J Virol. 2011;85:2012-23 pubmed publisher
    ..In this regard, using reciprocal coimmunoprecipitation analysis, we identified a 28-residue region predicted to form a coiled-coil domain (residues 92 to 119) as a newly recognized molecular determinant of N homotypic interactions...
  69. Marq J, Hausmann S, Veillard N, Kolakofsky D, Garcin D. Short double-stranded RNAs with an overhanging 5' ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys. J Biol Chem. 2011;286:6108-16 pubmed publisher
    b>Arenavirus RNA genomes are initiated by a "prime and realign" mechanism, such that the initiating GTP is found as a single unpaired (overhanging) nucleotide when the complementary genome ends anneal to form double-stranded (ds) ..
  70. Albarino C, Posik D, Ghiringhelli P, Lozano M, Romanowski V. Arenavirus phylogeny: a new insight. Virus Genes. 1998;16:39-46 pubmed
    ..phylogenetic analysis, strongly suggest a possible kinship of Pichindé and Oliveros viruses, with the Old World arenavirus group...
  71. Fennewald S, Scott E, Zhang L, Yang X, Aronson J, Gorenstein D, et al. Thioaptamer decoy targeting of AP-1 proteins influences cytokine expression and the outcome of arenavirus infections. J Gen Virol. 2007;88:981-90 pubmed
    ..These data demonstrate a proof of concept that thioaptamers can be used to modulate the outcome of in vivo viral infections by arenaviruses by the manipulation of transcription factors involved in the regulation of the immune response...
  72. Flatz L, Rieger T, Merkler D, Bergthaler A, Regen T, Schedensack M, et al. T cell-dependence of Lassa fever pathogenesis. PLoS Pathog. 2010;6:e1000836 pubmed publisher
    ..The possibility of T cell-driven enhancement and immunopathogenesis should be given consideration in future LF vaccine development...
  73. Ishii A, Thomas Y, Moonga L, Nakamura I, Ohnuma A, Hang ombe B, et al. Novel arenavirus, Zambia. Emerg Infect Dis. 2011;17:1921-4 pubmed publisher
    To investigate arenavirus in Zambia, we characterized virus from the kidneys of 5 arenavirus RNA-positive rodents (Mastomys natalensis) among 263 captured...
  74. Mendenhall M, Russell A, Smee D, Hall J, Skirpstunas R, Furuta Y, et al. Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. PLoS Negl Trop Dis. 2011;5:e1342 pubmed publisher
    ..At present, ribavirin is the only antiviral drug indicated for use in treatment of these diseases, but because of its limited efficacy in advanced cases of disease and its toxicity, safer and more effective antivirals are needed...
  75. Kunz S. The role of the vascular endothelium in arenavirus haemorrhagic fevers. Thromb Haemost. 2009;102:1024-9 pubmed publisher
    ..On the South American continent, the New World arenavirus Junin virus (JUNV), Machupo (MACV), Guanarito (GTOV), and Sabia virus (SABV) have emerged as causative agents of ..
  76. Capul A, de la Torre J. A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding. Virology. 2008;382:107-14 pubmed publisher
    ..In addition, compelling evidence indicates that the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen of clinical significance...
  77. York J, Dai D, Amberg S, Nunberg J. pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitors. J Virol. 2008;82:10932-9 pubmed publisher
    The arenavirus envelope glycoprotein (GPC) mediates viral entry through pH-induced membrane fusion in the endosome...