Summary: A genus of plant viruses of the family BROMOVIRIDAE, which infect cucurbits and solanaceous plants. Transmission occurs via aphids in a non-persistent manner, and also via seeds. The type species Cucumber mosaic virus, a CUCUMOVIRUS, should not be confused with Cucumber green mottle mosaic virus, a TOBAMOVIRUS.

Top Publications

  1. Thompson J, Doun S, Perry K. Compensatory capsid protein mutations in cucumber mosaic virus confer systemic infectivity in squash (Cucurbita pepo). J Virol. 2006;80:7740-3 pubmed
    ..The possible effect of these compensatory mutations on other, nonsystemically infecting loop mutants was tested with the F117A mutant and found to be neutral, thus indicating a specificity to the observed changes...
  2. Ziebell H, Payne T, Berry J, Walsh J, Carr J. A cucumber mosaic virus mutant lacking the 2b counter-defence protein gene provides protection against wild-type strains. J Gen Virol. 2007;88:2862-71 pubmed
    ..It is more likely that protection occurs through either induction of very highly localized RNA silencing, or by competition between strains for host cells or resources. ..
  3. Fukuzawa N, Ishihara T, Itchoda N, Tabayashi N, Kataoka C, Masuta C, et al. Risk-managed production of bioactive recombinant proteins using a novel plant virus vector with a helper plant to complement viral systemic movement. Plant Biotechnol J. 2011;9:38-49 pubmed publisher
  4. Takahashi H, Miller J, Nozaki Y, Takeda M, Shah J, Hase S, et al. RCY1, an Arabidopsis thaliana RPP8/HRT family resistance gene, conferring resistance to cucumber mosaic virus requires salicylic acid, ethylene and a novel signal transduction mechanism. Plant J. 2002;32:655-67 pubmed
    ..Moreover, our results suggest that the signaling pathways downstream of the RPP8, HRT, and RCY1 have evolved independently. ..
  5. Shi B, Miller J, Symons R, Palukaitis P. The 2b protein of cucumoviruses has a role in promoting the cell-to-cell movement of pseudorecombinant viruses. Mol Plant Microbe Interact. 2003;16:261-7 pubmed
    ..These data also suggest the existence of specific interaction between the TAV 2b protein and either RNA 3 or its encoded proteins, which may be critical for promoting or maintaining infection or both. ..
  6. Hwang M, Kim S, Lee J, Bae J, Paek K, Park Y. Evidence for interaction between the 2a polymerase protein and the 3a movement protein of Cucumber mosaic virus. J Gen Virol. 2005;86:3171-7 pubmed
    ..These results suggest that the replicase complex may be involved in movement through its interaction with the MP. ..
  7. Mayers C, Lee K, Moore C, Wong S, Carr J. Salicylic acid-induced resistance to Cucumber mosaic virus in squash and Arabidopsis thaliana: contrasting mechanisms of induction and antiviral action. Mol Plant Microbe Interact. 2005;18:428-34 pubmed
    ..These findings also imply that caution is required when attempting to apply findings on plant-virus interactions from model systems to a wider range of host species. ..
  8. Soards A, Murphy A, Palukaitis P, Carr J. Virulence and differential local and systemic spread of cucumber mosaic virus in tobacco are affected by the CMV 2b protein. Mol Plant Microbe Interact. 2002;15:647-53 pubmed
    ..We propose that this altered movement profile of Fny-CMVdelta2b results in the absence of disease symptoms in tobacco. ..
  9. Hajimorad M, Ghabrial S, Roossinck M. De novo emergence of a novel satellite RNA of cucumber mosaic virus following serial passages of the virus derived from RNA transcripts. Arch Virol. 2009;154:137-40 pubmed publisher
    ..Comparison of the sequences of the newly emerged satRNA with those of known CMV satRNAs showed that it is unique. This observation raises interesting questions regarding the enigmatic nature of the origin of CMV satRNAs. ..

More Information

Publications105 found, 100 shown here

  1. Ji L, Ding S. The suppressor of transgene RNA silencing encoded by Cucumber mosaic virus interferes with salicylic acid-mediated virus resistance. Mol Plant Microbe Interact. 2001;14:715-24 pubmed
    ..We propose that SA induces virus resistance by potentiating a RNA-silencing antiviral defense that is targeted by Cmv2b. ..
  2. Yoshii M, Nishikiori M, Tomita K, Yoshioka N, Kozuka R, Naito S, et al. The Arabidopsis cucumovirus multiplication 1 and 2 loci encode translation initiation factors 4E and 4G. J Virol. 2004;78:6102-11 pubmed
  3. Seo J, Kwon S, Choi H, Kim K. Evidence for alternate states of Cucumber mosaic virus replicase assembly in positive- and negative-strand RNA synthesis. Virology. 2009;383:248-60 pubmed publisher
    ..These results support the concept that two or more alternate states of replicase assembly are involved in CMV replication...
  4. Takeshita M, Suzuki M, Takanami Y. Combination of amino acids in the 3a protein and the coat protein of cucumber mosaic virus determines symptom expression and viral spread in bottle gourd. Arch Virol. 2001;146:697-711 pubmed
    ..Furthermore, Ser129 in the CPs was shown to be responsible for induction of HR and blocking of efficient cell-to-cell and long-distance movement. ..
  5. Takeshita M, Kikuhara K, Kuwata S, Furuya N, Takanami Y. Competition between wild-type virus and a reassortant from subgroups I and II of CMV and activation of antiviral responses in cowpea. Arch Virol. 2004;149:1851-7 pubmed
  6. Canto T, Choi S, Palukaitis P. A subpopulation of RNA 1 of Cucumber mosaic virus contains 3' termini originating from RNAs 2 or 3. J Gen Virol. 2001;82:941-5 pubmed
    ..Thus, these chimeras occur naturally due to recombination between wild-type viral RNAs, and they are found encapsidated in low, but detectable amounts. ..
  7. de Wispelaere M, Gaubert S, Trouilloud S, Belin C, Tepfer M. A map of the diversity of RNA3 recombinants appearing in plants infected with Cucumber mosaic virus and Tomato aspermy virus. Virology. 2005;331:117-27 pubmed
    ..They also provide essential baseline information for understanding the potential epidemiological impact of recombination in transgenic plants expressing viral sequences. ..
  8. Canto T, Palukaitis P. Subcellular distribution of mutant movement proteins of Cucumber mosaic virus fused to green fluorescent proteins. J Gen Virol. 2005;86:1223-8 pubmed
    ..Rather, they showed distribution to different extents throughout the infected cells, including the cytoplasm, nucleus or the plasma membrane. The CMV 3a MP also did not associate with microtubules. ..
  9. Chen H, Yang J, Lin C, Yuan Y. Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2b. EMBO Rep. 2008;9:754-60 pubmed publisher
    The 2b proteins encoded by cucumovirus act as post-transcriptional gene silencing suppressors to counter host defence during infection...
  10. Canto T, Palukaitis P. A cucumber mosaic virus (CMV) RNA 1 transgene mediates suppression of the homologous viral RNA 1 constitutively and prevents CMV entry into the phloem. J Virol. 2001;75:9114-20 pubmed
    ..The data indicate that this transgene-mediated systemic resistance probably is not based on a posttranscriptional gene-silencing mechanism. ..
  11. Aranda M, Fraile A, Dopazo J, Malpica J, Garcia Arenal F. Contribution of mutation and RNA recombination to the evolution of a plant pathogenic RNA. J Mol Evol. 1997;44:81-8 pubmed
    ..To our knowledge this is the first report of data allowing the frequency of recombinant isolates in natural populations of an RNA replicon to be estimated. ..
  12. Lin H, Rubio L, Smythe A, Jiminez M, Falk B. Genetic diversity and biological variation among California isolates of Cucumber mosaic virus. J Gen Virol. 2003;84:249-58 pubmed
    ..CMV isolates capable of infecting cucurbits with conventional and transgenic CMV resistance were present in California, even before CMV transgenic material was available. ..
  13. Handford M, Carr J. A defect in carbohydrate metabolism ameliorates symptom severity in virus-infected Arabidopsis thaliana. J Gen Virol. 2007;88:337-41 pubmed
    ..The results show that, although changes in starch accumulation during infection are not required for successful viral infection, carbohydrate metabolism does influence symptom development. ..
  14. Pagán I, Alonso Blanco C, García Arenal F. Host responses in life-history traits and tolerance to virus infection in Arabidopsis thaliana. PLoS Pathog. 2008;4:e1000124 pubmed publisher
  15. Nuzzaci M, Piazzolla G, Vitti A, Lapelosa M, Tortorella C, Stella I, et al. Cucumber mosaic virus as a presentation system for a double hepatitis C virus-derived epitope. Arch Virol. 2007;152:915-28 pubmed
    ..The high immunogen levels achievable in plants or fruits infected with 2R9-CMV suggest that this chimeric form of CMV may be useful in the development of oral vaccines against HCV. ..
  16. Hamera S, Song X, Su L, Chen X, Fang R. Cucumber mosaic virus suppressor 2b binds to AGO4-related small RNAs and impairs AGO4 activities. Plant J. 2012;69:104-15 pubmed publisher
    ..We propose that by adopting novel counter-host defense strategies against AGO1 and AGO4 proteins, CMV creates a favorable cellular niche for its proliferation. ..
  17. Adenot X, Elmayan T, Lauressergues D, Boutet S, Bouche N, Gasciolli V, et al. DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7. Curr Biol. 2006;16:927-32 pubmed
  18. Pagán I, Alonso Blanco C, García Arenal F. The relationship of within-host multiplication and virulence in a plant-virus system. PLoS ONE. 2007;2:e786 pubmed
    ..Thus, our results challenge the general validity of the trade-off hypothesis for virulence evolution, and stress the need of considering the effect of both the host and parasite genotypes in analyses of host-parasite interactions. ..
  19. Carr D, Murphy J, Eubanks M. Genetic variation and covariation for resistance and tolerance to Cucumber mosaic virus in Mimulus guttatus (Phrymaceae): a test for costs and constraints. Heredity (Edinb). 2006;96:29-38 pubmed
    ..Significant, positive genetic correlations found between performance of uninfected and infected plants suggested that selection would likely favor the same M. guttatus genotypes whether CMV is present or not...
  20. Wang X, Jovel J, Udomporn P, Wang Y, Wu Q, Li W, et al. The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana. Plant Cell. 2011;23:1625-38 pubmed publisher
    ..Possible mechanisms for the observed qualitative difference in RNA silencing between 21- and 22-nucleotide secondary siRNAs are discussed. ..
  21. Masuta C, Ueda S, Suzuki M, Uyeda I. Evolution of a quadripartite hybrid virus by interspecific exchange and recombination between replicase components of two related tripartite RNA viruses. Proc Natl Acad Sci U S A. 1998;95:10487-92 pubmed
    Cucumber mosaic virus (CMV) and tomato aspermy virus (TAV) belong to the Cucumovirus genus. They have a tripartite genome consisting of single-stranded RNAs, designated 1, 2, and 3...
  22. Roossinck M, Zhang L, Hellwald K. Rearrangements in the 5' nontranslated region and phylogenetic analyses of cucumber mosaic virus RNA 3 indicate radial evolution of three subgroups. J Virol. 1999;73:6752-8 pubmed
    ..In addition, strains within each subgroup radiate from a single point of origin, indicating that they have evolved from a single common ancestor for each subgroup. ..
  23. Mourrain P, Beclin C, Elmayan T, Feuerbach F, Godon C, Morel J, et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell. 2000;101:533-42 pubmed
    ..Both sgs2 and sgs3 mutants show enhanced susceptibility to virus, definitively proving that PTGS is an antiviral defense mechanism that can also target transgene RNA for degradation. ..
  24. Nurkiyanova K, Ryabov E, Kalinina N, Fan Y, Andreev I, Fitzgerald A, et al. Umbravirus-encoded movement protein induces tubule formation on the surface of protoplasts and binds RNA incompletely and non-cooperatively. J Gen Virol. 2001;82:2579-88 pubmed
    ..The significance of the two properties of limited RNA binding and tubule formation of the umbraviral MP is discussed. ..
  25. Wang M, Bian X, Wu L, Liu L, Smith N, Isenegger D, et al. On the role of RNA silencing in the pathogenicity and evolution of viroids and viral satellites. Proc Natl Acad Sci U S A. 2004;101:3275-80 pubmed
  26. Bonnet J, Fraile A, Sacristan S, Malpica J, García Arenal F. Role of recombination in the evolution of natural populations of Cucumber mosaic virus, a tripartite RNA plant virus. Virology. 2005;332:359-68 pubmed
    ..Data also suggest that recombinants that encode hybrid proteins are at a higher disadvantage than recombinants that exchange whole ORFs. ..
  27. Takeda A, Iwasaki S, Watanabe T, Utsumi M, Watanabe Y. The mechanism selecting the guide strand from small RNA duplexes is different among argonaute proteins. Plant Cell Physiol. 2008;49:493-500 pubmed publisher
    ..These results clearly indicate that the mechanism selecting the guide strand is different among AGO proteins and that multiple AGO genes are involved in anti-virus defense in plants. ..
  28. Harvey J, Lewsey M, Patel K, Westwood J, Heimstädt S, Carr J, et al. An antiviral defense role of AGO2 in plants. PLoS ONE. 2011;6:e14639 pubmed publisher
    ..Plants encode multiple AGO proteins but, in Arabidopsis, only AGO1 is known to have an antiviral role...
  29. Havelda Z, Maule A. Complex spatial responses to cucumber mosaic virus infection in susceptible Cucurbita pepo cotyledons. Plant Cell. 2000;12:1975-86 pubmed
    ..The experiments showed that virus infection induced immediate and subsequent changes in gene expression by the host and that the infection has the potential to give advance signaling of the imminent infection. ..
  30. Divéki Z, Salánki K, Balázs E. The necrotic pathotype of the cucumber mosaic virus (CMV) ns strain is solely determined by amino acid 461 of the 1a protein. Mol Plant Microbe Interact. 2004;17:837-45 pubmed
    ..Symptoms induced by the Trk7/R461C mutant were identical to those caused by wild-type Trk7-CMV, even when the mutant Trk7 RNA1 was co-inoculated with RNA2 and 3 of the necrotic Ns strain. ..
  31. Li Q, Ryu K, Palukaitis P. Cucumber mosaic virus-plant interactions: identification of 3a protein sequences affecting infectivity, cell-to-cell movement, and long-distance movement. Mol Plant Microbe Interact. 2001;14:378-85 pubmed
    ..From these mutants, different aspects of the CMV movement process could be defined and specific roles for particular sequence domains assigned. The broader implications of these functions are discussed. ..
  32. Chen Y, Chen J, Zhang H, Tang X, Du Z. Molecular evidence and sequence analysis of a natural reassortant between cucumber mosaic virus subgroup IA and II strains. Virus Genes. 2007;35:405-13 pubmed
    ..The results of the restriction enzyme analysis proved that CMV-Tsh is the unique strain in the tomato plant. Taken together, CMV-Tsh is a natural reassortant having CMV subgroup IA RNA2 and subgroup II RNAs 1 and 3. ..
  33. Llamas S, Moreno I, García Arenal F. Analysis of the viability of coat-protein hybrids between Cucumber mosaic virus and Tomato aspermy virus. J Gen Virol. 2006;87:2085-8 pubmed
    ..Need for MP-CP compatibility could explain these results, but shows that MP-CP compatibility conditions the use of CP chimeras to map CP-associated differences between CMV and TAV. ..
  34. González I, Martínez L, Rakitina D, Lewsey M, Atencio F, Llave C, et al. Cucumber mosaic virus 2b protein subcellular targets and interactions: their significance to RNA silencing suppressor activity. Mol Plant Microbe Interact. 2010;23:294-303 pubmed publisher
    ..In contrast, the ability of the 2b protein to bind small RNAs appears to be indispensable for silencing suppressor function. ..
  35. Lewsey M, Murphy A, Maclean D, Dalchau N, Westwood J, Macaulay K, et al. Disruption of two defensive signaling pathways by a viral RNA silencing suppressor. Mol Plant Microbe Interact. 2010;23:835-45 pubmed publisher
    ..Like many plant viruses, CMV is aphid transmitted. JA is important in plant defense against insects. This raises the possibility that disruption of JA-mediated gene expression by the 2b protein may influence CMV transmission by aphids...
  36. Murphy A, Carr J. Salicylic acid has cell-specific effects on tobacco mosaic virus replication and cell-to-cell movement. Plant Physiol. 2002;128:552-63 pubmed
    ..Thus, SA can have fundamentally different effects on the same pathogen in different cell types...
  37. Cillo F, Roberts I, Palukaitis P. In situ localization and tissue distribution of the replication-associated proteins of Cucumber mosaic virus in tobacco and cucumber. J Virol. 2002;76:10654-64 pubmed
    ..These observations may represent differences in the relative rates of tissue infection in different hosts or differences in the extent of virus replication in vascular tissues of different hosts...
  38. Yamaguchi N, Seshimo Y, Yoshimoto E, Ahn H, Ryu K, Choi J, et al. Genetic mapping of the compatibility between a lily isolate of Cucumber mosaic virus and a satellite RNA. J Gen Virol. 2005;86:2359-69 pubmed
    ..It is believed that, through evolution, the adaptation of CMV to lily resulted in the introduction of amino acid changes in the 1a protein, changes that coincidentally affected the ability of lily CMV to support satRNAs...
  39. Matsuo K, Hong J, Tabayashi N, Ito A, Masuta C, Matsumura T. Development of Cucumber mosaic virus as a vector modifiable for different host species to produce therapeutic proteins. Planta. 2007;225:277-86 pubmed
    ..Using this system, which provides a versatile and viable strategy for the production of therapeutic proteins in plants, we also demonstrated a high level of aFGF in Glycine max (soybean) and Arabidopsis thaliana...
  40. Requena A, Simon Buela L, Salcedo G, Garcia Arenal F. Potential involvement of a cucumber homolog of phloem protein 1 in the long-distance movement of Cucumber mosaic virus particles. Mol Plant Microbe Interact. 2006;19:734-46 pubmed
    ..These results indicate that the interaction with p48 modifies CMV particle structure and suggest that CMV particles interact with the cucumber homolog of PP1 during translocation in the sieve tubes...
  41. Du Q, Duan C, Zhang Z, Fang Y, Fang R, Xie Q, et al. DCL4 targets Cucumber mosaic virus satellite RNA at novel secondary structures. J Virol. 2007;81:9142-51 pubmed
    ..This result reveals that viral RNA of diverse structures may stimulate antiviral DCL activities in plant cells...
  42. Du Z, Chen F, Liao Q, Zhang H, Chen Y, Chen J. 2b ORFs encoded by subgroup IB strains of cucumber mosaic virus induce differential virulence on Nicotiana species. J Gen Virol. 2007;88:2596-604 pubmed
    ..Through analysis of encapsidation of viral RNAs, there was an apparent correlation between the virulence and the high level of encapsidated RNA 2 in virions of Fny-CMV, FCb7(2b)-CMV and FNa(2b)-CMV...
  43. Kang W, Hoang N, Yang H, Kwon J, Jo S, Seo J, et al. Molecular mapping and characterization of a single dominant gene controlling CMV resistance in peppers (Capsicum annuum L.). Theor Appl Genet. 2010;120:1587-96 pubmed publisher
    ..We expect that the SNP markers developed in this study will be useful for developing CMV-resistant cultivars and for fine mapping the Cmr1 gene...
  44. González I, Rakitina D, Semashko M, Taliansky M, Praveen S, Palukaitis P, et al. RNA binding is more critical to the suppression of silencing function of Cucumber mosaic virus 2b protein than nuclear localization. RNA. 2012;18:771-82 pubmed publisher
    ..They also show that cytoplasmically localized 2b protein retained suppressor activity, and that a sustained nuclear localization was not required for this function...
  45. Gellért A, Nemes K, Kádár K, Salánki K, Balázs E. The C-terminal domain of the 2b protein of Cucumber mosaic virus is stabilized by divalent metal ion coordination. J Mol Graph Model. 2012;38:446-54 pubmed publisher
    ..These results demonstrate that the quadruple mutation weakens the stability of the 2b protein tetramer-siRNA ribonucleoprotein complex...
  46. Xin H, Ji L, Scott S, Symons R, Ding S. Ilarviruses encode a Cucumovirus-like 2b gene that is absent in other genera within the Bromoviridae. J Virol. 1998;72:6956-9 pubmed
    ..which is not encoded by alfamoviruses and bromoviruses, shares several features with the previously reported cucumovirus 2b gene; however, their encoded proteins share no detectable sequence similarities...
  47. Roossinck M. Evolutionary history of Cucumber mosaic virus deduced by phylogenetic analyses. J Virol. 2002;76:3382-7 pubmed
    ..This indicates that functions other than replication are encoded in the 3' NTR. Reassortment may have led to the genetic diversity found among CMV strains and contributed to its enormous evolutionary success...
  48. Boutet S, Vazquez F, Liu J, Beclin C, Fagard M, Gratias A, et al. Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance. Curr Biol. 2003;13:843-8 pubmed
  49. Marathe R, Guan Z, Anandalakshmi R, Zhao H, Dinesh Kumar S. Study of Arabidopsis thaliana resistome in response to cucumber mosaic virus infection using whole genome microarray. Plant Mol Biol. 2004;55:501-20 pubmed
    ..Exploring the precise function of the new genes identified in this analysis will offer new insights into plant defense...
  50. Goto K, Kobori T, Kosaka Y, Natsuaki T, Masuta C. Characterization of silencing suppressor 2b of cucumber mosaic virus based on examination of its small RNA-binding abilities. Plant Cell Physiol. 2007;48:1050-60 pubmed
    ..Here we consider that 2b interferes with the PTGS pathway by directly binding siRNAs (or long dsRNA)...
  51. Du Z, Chen F, Zhao Z, Liao Q, Palukaitis P, Chen J. The 2b protein and the C-terminus of the 2a protein of cucumber mosaic virus subgroup I strains both play a role in viral RNA accumulation and induction of symptoms. Virology. 2008;380:363-70 pubmed publisher
    ..Thus, the 2a protein C-terminus of subgroup I strains, as well as the 2b protein, play a role in symptom induction and accumulation of viral RNAs...
  52. Wang X, Wu Q, Ito T, Cillo F, Li W, Chen X, et al. RNAi-mediated viral immunity requires amplification of virus-derived siRNAs in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2010;107:484-9 pubmed publisher
    ..Our work thus identifies a distinct mechanism for the amplification of immunity effectors, which together with the requirement for the biogenesis of endogenous siRNAs, may play a role in the emergence and expansion of eukaryotic RDRs...
  53. Roossinck M, Kaplan I, Palukaitis P. Support of a cucumber mosaic virus satellite RNA maps to a single amino acid proximal to the helicase domain of the helper virus. J Virol. 1997;71:608-12 pubmed
    ..Support of satellite RNA in whole plants and in protoplasts of zucchini squash is analyzed...
  54. Nagano H, Mise K, Furusawa I, Okuno T. Conversion in the requirement of coat protein in cell-to-cell movement mediated by the cucumber mosaic virus movement protein. J Virol. 2001;75:8045-53 pubmed
    ..This is the first report that a region of MP determines the requirement of CP in cell-to-cell movement of a plant virus...
  55. Palukaitis P, García Arenal F. Cucumoviruses. Adv Virus Res. 2003;62:241-323 pubmed
    ..b>Cucumovirus genome structures have been analyzed, giving new insights into their genetic variability, evolution, and ..
  56. Pacios L, García Arenal F. Comparison of properties of particles of Cucumber mosaic virus and Tomato aspermy virus based on the analysis of molecular surfaces of capsids. J Gen Virol. 2006;87:2073-83 pubmed
    The plant RNA viruses Cucumber mosaic virus (CMV) and Tomato aspermy virus (TAV) (genus Cucumovirus) have similar icosahedral particles, the crystal structures of which have been reported recently...
  57. Feng J, Chen S, Tang X, Ding X, Du Z, Chen J. Quantitative determination of cucumber mosaic virus genome RNAs in virions by real-time reverse transcription-polymerase chain reaction. Acta Biochim Biophys Sin (Shanghai). 2006;38:669-76 pubmed
    ..17:3.58:5.81. These results were confirmed by Lab-on-a-chip and northern blot hybridization assays. Our work is the first report concerning the relative amounts of different RNA fragments in CMV virions as a virus with tripartite genome...
  58. Sudarshana M, Plesha M, Uratsu S, Falk B, Dandekar A, Huang T, et al. A chemically inducible cucumber mosaic virus amplicon system for expression of heterologous proteins in plant tissues. Plant Biotechnol J. 2006;4:551-9 pubmed
    ..Significantly, 70% of the rAAT produced using the CMViva expression system was found to be biologically active, a 170-fold increase in functional protein compared with the CaMV 35S expression system...
  59. Fu X, Ye L, Kang L, Ge F. Elevated CO2 shifts the focus of tobacco plant defences from cucumber mosaic virus to the green peach aphid. Plant Cell Environ. 2010;33:2056-64 pubmed publisher
    ..Plant defence appears to shift from plant virus to aphid under increasing CO(2) levels, which highlights the potential influences of multiple biotic stressors on plants under elevated CO(2)...
  60. Takeshita M, Shigemune N, Kikuhara K, Furuya N, Takanami Y. Spatial analysis for exclusive interactions between subgroups I and II of Cucumber mosaic virus in cowpea. Virology. 2004;328:45-51 pubmed
    ..Taken together, it is suggested that the dynamics of competitive interactions between the two subgroups could be characterized by exclusive infection and multiplication of the individual viruses in cowpea plants...
  61. Kim M, Ham B, Kim H, Lee I, Kim Y, Ryu K, et al. In vitro and in planta interaction evidence between Nicotiana tabacum thaumatin-like protein 1 (TLP1) and cucumber mosaic virus proteins. Plant Mol Biol. 2005;59:981-94 pubmed publisher
    ..Real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that the expression of NtTLP1 increased as the result of CMV inoculation...
  62. Kim M, Huh S, Ham B, Paek K. A novel methyltransferase methylates Cucumber mosaic virus 1a protein and promotes systemic spread. J Virol. 2008;82:4823-33 pubmed publisher
    ..The overexpression of Tcoi1 enhanced the CMV infection, while the reduced expression of Tcoi1 decreased virus infectivity. These results suggest that Tcoi1 controls the propagation of CMV through an interaction with the CMV 1a protein...
  63. Mauck K, De Moraes C, Mescher M. Deceptive chemical signals induced by a plant virus attract insect vectors to inferior hosts. Proc Natl Acad Sci U S A. 2010;107:3600-5 pubmed publisher
  64. Inaba J, Kim B, Shimura H, Masuta C. Virus-induced necrosis is a consequence of direct protein-protein interaction between a viral RNA-silencing suppressor and a host catalase. Plant Physiol. 2011;156:2026-36 pubmed publisher
  65. Takeshita M, Koizumi E, Noguchi M, Sueda K, Shimura H, Ishikawa N, et al. Infection dynamics in viral spread and interference under the synergism between Cucumber mosaic virus and Turnip mosaic virus. Mol Plant Microbe Interact. 2012;25:18-27 pubmed publisher
    ..This observation suggested that local interference between two viruses was established even in the synergism between CMV and TuMV and, again, RNA silencing did not seem to contribute greatly to this phenomenon...
  66. Ziebell H, Murphy A, Groen S, Tungadi T, Westwood J, Lewsey M, et al. Cucumber mosaic virus and its 2b RNA silencing suppressor modify plant-aphid interactions in tobacco. Sci Rep. 2011;1:187 pubmed publisher
    ..Our findings suggest that the 2b protein could indirectly affect aphid-mediated virus transmission...
  67. Tamura A, Kato T, Taki A, Sone M, Satoh N, Yamagishi N, et al. Preventive and curative effects of Apple latent spherical virus vectors harboring part of the target virus genome against potyvirus and cucumovirus infections. Virology. 2013;446:314-24 pubmed publisher
    ..This may be due to the invasion of ALSV, but not ZYMV, in the shoot apical meristem of cucumber. ..
  68. Rodriguez Alvarado G, Roossinck M. Structural analysis of a necrogenic strain of cucumber mosaic cucumovirus satellite RNA in planta. Virology. 1997;236:155-66 pubmed
    ..In this study we analyzed the structure of cucumber mosaic cucumovirus satellite RNA (sat RNA) strain D4 in vivo and compared it to the structures found in vitro and in purified ..
  69. Shi B, Palukaitis P, Symons R. Differential virulence by strains of Cucumber mosaic virus is mediated by the 2b gene. Mol Plant Microbe Interact. 2002;15:947-55 pubmed
  70. Suzuki M, Hibi T, Masuta C. RNA recombination between cucumoviruses: possible role of predicted stem-loop structures and an internal subgenomic promoter-like motif. Virology. 2003;306:77-86 pubmed
    ..The possible role of secondary structures and an internal subgenomic promoter-like motif in RNA recombination is discussed...
  71. Piazzolla G, Nuzzaci M, Tortorella C, Panella E, Natilla A, Boscia D, et al. Immunogenic properties of a chimeric plant virus expressing a hepatitis C virus (HCV)-derived epitope: new prospects for an HCV vaccine. J Clin Immunol. 2005;25:142-52 pubmed
    ..Our results open up new prospects for the development of effective vaccines against HCV infection. Moreover, the wide edible host range of CMV makes the production of an edible vaccine conceivable...
  72. Shi B, Symons R, Palukaitis P. The cucumovirus 2b gene drives selection of inter-viral recombinants affecting the crossover site, the acceptor RNA and the rate of selection. Nucleic Acids Res. 2008;36:1057-71 pubmed publisher
    ..The recombination occurred in a non-random manner, involved no intermediates and probably was generated via a copy-choice mechanism during (+) strand RNA synthesis...
  73. Lewsey M, Carr J. Effects of DICER-like proteins 2, 3 and 4 on cucumber mosaic virus and tobacco mosaic virus infections in salicylic acid-treated plants. J Gen Virol. 2009;90:3010-4 pubmed publisher
    ..However, the findings do not exclude RNA silencing from making a contribution to SA-mediated resistance in wild-type plants...
  74. Hou W, Duan C, Fang R, Zhou X, Guo H. Satellite RNA reduces expression of the 2b suppressor protein resulting in the attenuation of symptoms caused by Cucumber mosaic virus infection. Mol Plant Pathol. 2011;12:595-605 pubmed publisher
    ..Our data provide evidence that a plant silencing mechanism is involved in the pathogenicity of satRNA...
  75. Scholthof K, Adkins S, Czosnek H, Palukaitis P, Jacquot E, Hohn T, et al. Top 10 plant viruses in molecular plant pathology. Mol Plant Pathol. 2011;12:938-54 pubmed publisher
  76. Xu A, Zhao Z, Chen W, Zhang H, Liao Q, Chen J, et al. Self-interaction of the cucumber mosaic virus 2b protein plays a vital role in the suppression of RNA silencing and the induction of viral symptoms. Mol Plant Pathol. 2013;14:803-12 pubmed publisher
    ..Thus, self-interaction is crucial to the ability of the 2b protein to suppress silencing and induce a symptom-like phenotype, and is dependent on the properties of the residue at position 55...
  77. Kim C, Palukaitis P. The plant defense response to cucumber mosaic virus in cowpea is elicited by the viral polymerase gene and affects virus accumulation in single cells. EMBO J. 1997;16:4060-8 pubmed
  78. Xu P, Roossinck M. Cucumber mosaic virus D satellite RNA-induced programmed cell death in tomato. Plant Cell. 2000;12:1079-92 pubmed
    ..Analysis of the accumulation of minus- and plus-strand satRNAs in the infected plants indicates a correlation between high amounts of minus-strand satRNA and tomato cell death...
  79. Chen Y, Goldbach R, Prins M. Inter- and intramolecular recombinations in the cucumber mosaic virus genome related to adaptation to alstroemeria. J Virol. 2002;76:4119-24 pubmed
    ..Competition experiments revealed that these recombined RNA 2 and 3 segments increased the biological fitness of CMV in alstroemeria...
  80. Escriu F, Fraile A, García Arenal F. The evolution of virulence in a plant virus. Evolution. 2003;57:755-65 pubmed
    ..An important conclusion from both models was that the density of the aphid vector's population is a major factor in the evolution of CMV virulence. This may be relevant for the design of control strategies for CMV-induced diseases...
  81. Natilla A, Piazzolla G, Nuzzaci M, Saldarelli P, Tortorella C, Antonaci S, et al. Cucumber mosaic virus as carrier of a hepatitis C virus-derived epitope. Arch Virol. 2004;149:137-54 pubmed
    ..These results suggest that further investigation should be made into a possible vaccine function for the CMV-HCV mimotope system...
  82. Wang Y, Tzfira T, Gaba V, Citovsky V, Palukaitis P, Gal On A. Functional analysis of the Cucumber mosaic virus 2b protein: pathogenicity and nuclear localization. J Gen Virol. 2004;85:3135-47 pubmed
    ..Thus, the sequences corresponding to the two NLSs must have another role leading to pathogenicity enhancement...
  83. Zhang X, Yuan Y, Pei Y, Lin S, Tuschl T, Patel D, et al. Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes Dev. 2006;20:3255-68 pubmed
    ..These findings provide insight on the molecular arms race between host antiviral RNA silencing and virus counterdefense...
  84. Takeshita M, Matsuo Y, Suzuki M, Furuya N, Tsuchiya K, Takanami Y. Impact of a defective RNA 3 from cucumber mosaic virus on helper virus infection dynamics. Virology. 2009;389:59-65 pubmed publisher
    ..mosaic virus (CMV-Y), was further characterized in combination with different helper viruses in the genus Cucumovirus. Interestingly, Nicotiana benthamiana plants inoculated with CMV-D8 and D3Yalpha developed systemic symptoms ..
  85. Lewsey M, Surette M, Robertson F, Ziebell H, Choi S, Ryu K, et al. The role of the Cucumber mosaic virus 2b protein in viral movement and symptom induction. Mol Plant Microbe Interact. 2009;22:642-54 pubmed publisher
    ..Taken together, the results indicate that the 2b protein itself is an important symptom determinant in certain hosts. However, they also suggest that the protein may somehow synergize symptom induction by other CMV-encoded factors...
  86. Westwood J, McCann L, Naish M, Dixon H, Murphy A, Stancombe M, et al. A viral RNA silencing suppressor interferes with abscisic acid-mediated signalling and induces drought tolerance in Arabidopsis thaliana. Mol Plant Pathol. 2013;14:158-70 pubmed publisher
    ..Under natural conditions, virus-induced drought tolerance may serve viruses by aiding susceptible hosts to survive periods of environmental stress...
  87. Szilassy D, Salánki K, Balazs E. Stunting induced by cucumber mosaic cucumovirus-infected Nicotiana glutinosa is determined by a single amino acid residue in the coat protein. Mol Plant Microbe Interact. 1999;12:1105-13 pubmed
    R-CMV, a subgroup II strain of cucumber mosaic cucumovirus (CMV) induces a very strong stunting response in Nicotiana glutinosa plants, while Trk7-CMV causes green mosaic in this host...
  88. Kim M, Kao C. Factors regulating template switch in vitro by viral RNA-dependent RNA polymerases: implications for RNA-RNA recombination. Proc Natl Acad Sci U S A. 2001;98:4972-7 pubmed
    ..Our results provide biochemical support for copy-choice recombination and establish assays for mechanistic analyses of intermolecular RNA recombination in vitro...
  89. Kalantidis K, Psaradakis S, Tabler M, Tsagris M. The occurrence of CMV-specific short Rnas in transgenic tobacco expressing virus-derived double-stranded RNA is indicative of resistance to the virus. Mol Plant Microbe Interact. 2002;15:826-33 pubmed
    ..Those lines were CMV resistant. The correlation between the detection of short RNAs and virus resistance provides a molecular marker that makes it possible to predict success in attempts to engineer virus resistance by dsRNA...
  90. Senda M, Masuta C, Ohnishi S, Goto K, Kasai A, Sano T, et al. Patterning of virus-infected Glycine max seed coat is associated with suppression of endogenous silencing of chalcone synthase genes. Plant Cell. 2004;16:807-18 pubmed
    ..These results demonstrate that naturally occurring PTGS plays a key role in expression of a distinctive phenotype in plants and present a simple clear example of the elucidation of the molecular mechanism for viral symptom induction...
  91. Gellért A, Salánki K, Náray Szabó G, Balázs E. Homology modelling and protein structure based functional analysis of five cucumovirus coat proteins. J Mol Graph Model. 2006;24:319-27 pubmed
    Coat proteins (CP) of five cucumovirus isolates, Cucumber mosaic virus (CMV) strains R, M and Trk7, Tomato aspermy virus (TAV) strain P and Peanut stunt virus (PSV) strain Er, were constructed by homology modelling...
  92. Salánki K, Gellért A, Náray Szabó G, Balázs E. Modeling-based characterization of the elicitor function of amino acid 461 of Cucumber mosaic virus 1a protein in the hypersensitive response. Virology. 2007;358:109-18 pubmed
    ..Inoculation of purified Ns-CMV virions at extremely high concentration provoked systemic symptoms...