ovine caprine lentiviruses

Summary

Summary: A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in sheep and goats.

Top Publications

  1. Reina R, Grego E, Profiti M, Glaria I, Robino P, Quasso A, et al. Development of specific diagnostic test for small ruminant lentivirus genotype E. Vet Microbiol. 2009;138:251-7 pubmed publisher
  2. Rwambo P, Brodie S, DeMartini J. Ovine lentivirus is aetiologically associated with chronic respiratory disease of sheep on the Laikipia Plateau in Kenya. Trop Anim Health Prod. 2001;33:471-87 pubmed
    ..These results document the first identification of OvLV as a cause of chronic respiratory disease in sheep in Kenya and show a high rate of infection in sheep flocks, with a high prevalence of chronic respiratory disease...
  3. Glaria I, Reina R, Crespo H, de Andrés X, Ramirez H, Biescas E, et al. Phylogenetic analysis of SRLV sequences from an arthritic sheep outbreak demonstrates the introduction of CAEV-like viruses among Spanish sheep. Vet Microbiol. 2009;138:156-62 pubmed publisher
    ..This outbreak study represents the first report on CAEV-like genetic findings and complete genome analysis among Spanish small ruminants...
  4. Herrmann L, Hötzel I, Cheevers W, On Top K, Lewis G, Knowles D. Seven new ovine progressive pneumonia virus (OPPV) field isolates from Dubois Idaho sheep comprise part of OPPV clade II based on surface envelope glycoprotein (SU) sequences. Virus Res. 2004;102:215-20 pubmed
    ..These data indicate that the seven new Dubois OPPV field isolates along with WLC1 OPPV are part of the OPPV clade II and are distinct from CAEVs and MVVs...
  5. Keen J, Hungerford L, Wittum T, Kwang J, Littledike E. Risk factors for seroprevalence of ovine lentivirus in breeding ewe flocks in Nebraska, USA. Prev Vet Med. 1997;30:81-94 pubmed
    ..These findings support the hypothesis that management control efforts should concentrate on events early in the life of sheep, as this period is associated with factors which can modulate the risk for OLV infection...
  6. Angelopoulou K, Karanikolaou K, Papanastasopoulou M, Koumpati Artopiou M, Vlemmas I, Papadopoulos O, et al. First partial characterisation of small ruminant lentiviruses from Greece. Vet Microbiol. 2005;109:1-9 pubmed
    ..Phylogenetic analysis suggested that Greek strains segregate into a unique group, separate from, but related to, other ovine prototype sequences...
  7. Juste R, Ott T, Kwang J, Bazer F, de la Concha Bermejillo A. Effects of recombinant ovine interferon-tau on ovine lentivirus replication and progression of disease. J Gen Virol. 2000;81:525-32 pubmed
    ..These results indicate that roIFN-tau curtails OvLV replication in vivo and reduces the likelihood of development of lentivirus-induced LIP when infected lambs are treated during the initial phases of OvLV infection...
  8. Kwang J, Torres J. Oligopeptide-based enzyme immunoassay for ovine lentivirus antibody detection. J Clin Microbiol. 1994;32:1813-5 pubmed
    ..Immunodominant epitopes have been identified in the envelope gp40 glycoprotein. Synthetic peptides representing these regions are able to detect the presence of OPPV antibodies in 96% of infected sheep...
  9. Ellis J, Russell H, Du C. Effect of selected cytokines on the replication of Corynebacterium pseudotuberculosis and ovine lentiviruses in pulmonary macrophages. Vet Immunol Immunopathol. 1994;40:31-47 pubmed
    ..pseudotuberculosis infection may have little direct effect on the extra- or intracellular survival of the bacteria in the lung, but may modulate lentiviral replication and, by extension, disease expression, in sheep with dual infection...

More Information

Publications55

  1. Brodie S, de la Concha Bermejillo A, Koenig G, Snowder G, DeMartini J. Maternal factors associated with prenatal transmission of ovine lentivirus. J Infect Dis. 1994;169:653-7 pubmed
    ..These results suggest that maternal factors (age and parity) and host-virus interactions (antiviral antibody and antigenemia) are important risk factors in prenatal transmission of OvLV...
  2. Leroux C, Chastang J, Greenland T, Mornex J. Genomic heterogeneity of small ruminant lentiviruses: existence of heterogeneous populations in sheep and of the same lentiviral genotypes in sheep and goats. Arch Virol. 1997;142:1125-37 pubmed
    ..A phylogenetic tree of pol gene sequences confirmed the presence of a novel genotype of SRLV in France...
  3. de la Concha Bermejillo A, Juste R, Kretschmer R, Aguilar Setien A. Ovine lentivirus infection: an animal model for pediatric HIV infection?. Arch Med Res. 1995;26:345-54 pubmed
    ..Similarities between HIV and OvLV argue for the use of ovine lentivirus infection as a model to advance in the understanding of some of the aspects of HIV infection.(ABSTRACT TRUNCATED AT 250 WORDS)..
  4. Hudachek S, Kraft S, Thamm D, Bielefeldt Ohmann H, DeMartini J, Miller A, et al. Lung tumor development and spontaneous regression in lambs coinfected with Jaagsiekte sheep retrovirus and ovine lentivirus. Vet Pathol. 2010;47:148-62 pubmed publisher
    ..Overall, the genetic profile combined with the disease development data provides further important characterization of OPA and describes, for the first time, spontaneous regression of OPA tumors in experimentally infected sheep...
  5. Gil A, Rola M, Kuzmak J. Application of PCR technique in diagnosis of small ruminant lentivirus infection in sheep and goats. Pol J Vet Sci. 2006;9:213-7 pubmed
    ..In conclusion, the data demonstrated that combinations of both ELISA and PCR might afford optimal detection of SRLVs infection...
  6. Juste R, Kwang J, de la Concha Bermejillo A. Dynamics of cell-associated viremia and antibody response during the early phase of lentivirus infection in sheep. Am J Vet Res. 1998;59:563-8 pubmed
    ..To determine patterns of cell-associated viremia and antibody responses during the early phase of ovine lentivirus (OvLV) infection in sheep...
  7. Kwang J, Rosati S, Yang S, Juste R, de la Concha Bermejillo A. Recognition of ovine lentivirus gag gene products by serum from infected sheep. Vet Immunol Immunopathol. 1996;55:107-14 pubmed
    ..Given the broad immunoreactivity of the amino-terminal of p25, this region could serve as an ideal diagnostic antigen for the serological identification of OLV-infected sheep...
  8. Cortez Romero C, Fieni F, Roux C, Russo P, Guibert J, Guiguen F, et al. Detection of ovine lentivirus in the cumulus cells, but not in the oocytes or follicular fluid, of naturally infected sheep. Theriogenology. 2006;66:1131-9 pubmed
    ..In addition, the enzymatic and mechanical procedures we used to remove infected-cumulus cells surrounding the oocytes, are effective to generate MVV free-oocytes from MVV-infected ewes...
  9. Reina R, Grego E, Bertolotti L, De Meneghi D, Rosati S. Genome analysis of small-ruminant lentivirus genotype E: a caprine lentivirus with natural deletions of the dUTPase subunit, vpr-like accessory gene, and 70-base-pair repeat of the U3 region. J Virol. 2009;83:1152-5 pubmed publisher
    ..Since a reduced viral load and/or disease progression was observed for viruses with artificially deleted dUTPase and vpr-like genes, it is proposed that this viral cluster be designated a low-pathogenicity caprine lentivirus...
  10. Bogdan J, Newlands Monteith C, Ellis J. Nitric oxide production following in vitro stimulation of ovine pulmonary alveolar macrophages. Vet Immunol Immunopathol. 1997;56:299-310 pubmed
    ..Species differences in inducible NO production may affect the efficacy of clearance of bacterial infections and be responsible for inter-host differences in disease expression following infection by intracellular pathogens...
  11. Da Silva Teixeira M, Lambert V, Mselli Lakahl L, Chettab A, Chebloune Y, Mornex J. Immortalization of caprine fibroblasts permissive for replication of small ruminant lentiviruses. Am J Vet Res. 1997;58:579-84 pubmed
    ..To establish immortalized caprine fibroblastic cell lines permissive for replication of small ruminant lentiviruses...
  12. Karr B, Chebloune Y, Leung K, Narayan O. Genetic characterization of two phenotypically distinct North American ovine lentiviruses and their possible origin from caprine arthritis-encephalitis virus. Virology. 1996;225:1-10 pubmed
  13. Grego E, Lacerenza D, Arias R, Profiti M, Rosati S. Serological characterization of the new genotype E of small ruminant lentivirus in Roccaverano goat flocks. Vet Res Commun. 2009;33 Suppl 1:137-40 pubmed publisher
    ..The results clearly indicate that a strain specific antigen is required to correctly identify animals infected with different genotypes...
  14. Reina R, Bertolotti L, Dei Giudici S, Puggioni G, Ponti N, Profiti M, et al. Small ruminant lentivirus genotype E is widespread in Sarda goat. Vet Microbiol. 2010;144:24-31 pubmed publisher
    ..Data presented suggest diffusion of genotype E is wider than previously thought...
  15. Herrmann Hoesing L, Noh S, Snekvik K, White S, Schneider D, Truscott T, et al. Ovine progressive pneumonia virus capsid antigen as found in CD163- and CD172a-positive alveolar macrophages of persistently infected sheep. Vet Pathol. 2010;47:518-28 pubmed publisher
  16. Campbell B, Avery R. Sequence analysis and transcriptional activity of the LTR of OLV-CU1, a North American ovine lentivirus. J Gen Virol. 1996;77 ( Pt 12):2999-3004 pubmed
    ..In contrast to visna virus, the downstream region beyond the transcriptional start site was required for virus-specific transactivation...
  17. Clements J, Zink M. Molecular biology and pathogenesis of animal lentivirus infections. Clin Microbiol Rev. 1996;9:100-17 pubmed
    ..These animal lentiviruses have been used to examine, in particular, the pathogenesis of lentivirus-induced central nervous system disease as models for humans with AIDS as well as other chronic diseases...
  18. Eltahir Y, Dovas C, Papanastassopoulou M, Koumbati M, Giadinis N, Verghese Nikolakaki S, et al. Development of a semi-nested PCR using degenerate primers for the generic detection of small ruminant lentivirus proviral DNA. J Virol Methods. 2006;135:240-6 pubmed
    ..Whole blood samples can be used directly, thus alleviating the need for PBMC separation, and thereby enables a simple, fast and cost-effective analysis of a large number of samples...
  19. Ramirez H, Román B, Glaria I, Reina R, Hernandez M, de Andrés X, et al. Antibody-based diagnosis of small ruminant lentivirus infection in seminal fluid. Theriogenology. 2009;72:1085-96 pubmed publisher
    ..91 +/- 0.81). Thus, SF ELISA can be reliably applied in antibody-based SRLV diagnosis. This information may be useful to control infection in AICs and animal and semen trade programs requiring health-certified quality of semen donors...
  20. Woodward T, Carlson J, McClelland C, DeMartini J. Analysis of lentiviral genomic variation by denaturing gradient gel electrophoresis. Biotechniques. 1994;17:366-71 pubmed
    ..With this technique we have been able to detect sequence variations between and within virus isolates and to show evolution of the predominant viral species upon in vivo passage...
  21. Blacklaws B, Berriatua E, Torsteinsdottir S, Watt N, de Andres D, Klein D, et al. Transmission of small ruminant lentiviruses. Vet Microbiol. 2004;101:199-208 pubmed
    ..However, such transmission has not been demonstrated to date. The application of control measures based on this information allows more efficient strategies to be developed which will reduce the rate of transmission...
  22. Brodie S, Pearson L, Zink M, Bickle H, Anderson B, Marcom K, et al. Ovine lentivirus expression and disease. Virus replication, but not entry, is restricted to macrophages of specific tissues. Am J Pathol. 1995;146:250-63 pubmed
  23. Leroux C, Vuillermoz S, Mornex J, Greenland T. Genomic heterogeneity in the pol region of ovine lentiviruses obtained from bronchoalveolar cells of infected sheep from France. J Gen Virol. 1995;76 ( Pt 6):1533-7 pubmed
    ..2-6.9%. Phylogenetic analysis showed that the French isolates form a group related to CAEV Co and distant from previously reported ovine lentivirus sequences from different origins...
  24. Brinkhof J, Moll L, van Maanen C, Houwers D. Use of serology and polymerase chain reaction for the rapid eradication of small ruminant lentivirus infections from a sheep flock: a case report. Res Vet Sci. 2010;88:41-3 pubmed publisher
    ..PCR also saved two lambs from being culled; they were sero-positive probably due to maternal antibodies, but not infected...
  25. Herrmann L, McGuire T, Hötzel I, Lewis G, Knowles D. Surface envelope glycoprotein is B-lymphocyte immunodominant in sheep naturally infected with ovine progressive pneumonia virus. Clin Diagn Lab Immunol. 2005;12:797-800 pubmed
    ..Since these data indicate that SU is the immunodominant protein in most mature sheep persistently infected with OPPV, SU-specific diagnostic serological assays can be utilized for OPPV diagnosis...
  26. de la Concha Bermejillo A, Magnus Corral S, Brodie S, DeMartini J. Venereal shedding of ovine lentivirus in infected rams. Am J Vet Res. 1996;57:684-8 pubmed
    ..To assess shedding of ovine lentivirus (OvLV) in semen of infected rams with or without epididymitis...
  27. Shah C, Böni J, Huder J, Vogt H, Mühlherr J, Zanoni R, et al. Phylogenetic analysis and reclassification of caprine and ovine lentiviruses based on 104 new isolates: evidence for regular sheep-to-goat transmission and worldwide propagation through livestock trade. Virology. 2004;319:12-26 pubmed
    ..Furthermore, infection of goats by subtypes A3 or A4 was significantly associated with documented contact with sheep, which also harbor these subtypes, thus indicating regularly occurring sheep-to-goat transmission...
  28. Singh B, Ott T, Bazer F, de la Concha Bermejillo A. Structural responses of pulmonary intravascular macrophages in lentivirus-infected and/or recombinant ovine interferon-tau-treated lambs. Anat Rec. 1998;251:472-85 pubmed
    ..The loss of PIMs, probably infected with OvLV, either through direct killing by roIFN-tau or indirectly by roIFN-tau-activated cytotoxic T lymphocytes may represent different aspects of therapeutic actions of this cytokine...
  29. Singh B, de la Concha Bermejillo A. Gadolinium chloride removes pulmonary intravascular macrophages and curtails the degree of ovine lentivirus-induced lymphoid interstitial pneumonia. Int J Exp Pathol. 1998;79:151-62 pubmed
    ..The results also strengthen the usefulness of GC as a tool to study in vivo function of cells such as PIMs that are difficult to isolate for in vitro studies...
  30. Lacerenza D, Genovese F, Profiti M, Nucera D, Rosati S. Characterization of an immunodominant epitope of small ruminant lentivirus (SRLV) nucleoprotein. Vet Immunol Immunopathol. 2008;125:361-7 pubmed publisher
    ..However, in contrast to matrix and capsid antigen epitopes, which drive a genotype-specific immunoresponse, a moderate degree of variation was identified in NP independently of the genotype to which it belongs...
  31. Rosati S, Kwang J, Tolari F, Keen J. A comparison of whole virus and recombinant transmembrane ELISA and immunodiffusion for detection of ovine lentivirus antibodies in Italian sheep flocks. Vet Res Commun. 1994;18:73-80 pubmed
    ..It is concluded that the r-TM ELISA was more sensitive than the AGID test but less sensitive that the WV ELISA, particularly for detecting antibodies in the early stages of infection...
  32. Keen J, Kwang J, Rosati S. Comparison of ovine lentivirus detection by conventional and recombinant serological methods. Vet Immunol Immunopathol. 1995;47:295-309 pubmed
  33. Craig L, Nealen M, Strandberg J, Zink M. Differential replication of ovine lentivirus in endothelial cells cultured from different tissues. Virology. 1997;238:316-26 pubmed
    ..Replication of OvLV in brain capillary endothelial cells could play a role in the pathogenesis of lentiviral encephalitis by altering blood-brain barrier integrity...
  34. Singh D, Chebloune Y, Mselli Lakhal L, Karr B, Narayan O. Ovine lentivirus-infected macrophages mediate productive infection in cell types that are not susceptible to infection with cell-free virus. J Gen Virol. 1999;80 ( Pt 6):1437-44 pubmed
    ..This strategy could be one of the mechanisms involved in the escape from immune surveillance and establishment of persistent infection in infected animals...
  35. Castro R, Greenland T, Leite R, Gouveia A, Mornex J, Cordier G. Conserved sequence motifs involving the tat reading frame of Brazilian caprine lentiviruses indicate affiliations to both caprine arthritis-encephalitis virus and visna-maedi virus. J Gen Virol. 1999;80 ( Pt 7):1583-9 pubmed
    ..This may be useful for epizoological tracing of the origin of outbreaks...
  36. Curran M, Nolan G. Nonprimate lentiviral vectors. Curr Top Microbiol Immunol. 2002;261:75-105 pubmed
  37. Rosati S, Profiti M, Lorenzetti R, Bandecchi P, Mannelli A, Ortoffi M, et al. Development of recombinant capsid antigen/transmembrane epitope fusion proteins for serological diagnosis of animal lentivirus infections. J Virol Methods. 2004;121:73-8 pubmed
    ..The corresponding CA/TM antigen from EIAV showed excellent agreement with Coggins test...
  38. Herrmann Hoesing L, Palmer G, Knowles D. Evidence of proviral clearance following postpartum transmission of an ovine lentivirus. Virology. 2007;362:226-34 pubmed
    ..These data suggest the clearance of cell-associated lentiviruses from lamb circulation after passive transfer of antibody via colostrum...
  39. Mordasini F, Vogt H, Zahno M, Maeschli A, Nenci C, Zanoni R, et al. Analysis of the antibody response to an immunodominant epitope of the envelope glycoprotein of a lentivirus and its diagnostic potential. J Clin Microbiol. 2006;44:981-91 pubmed
    ..Under Swiss field conditions, the SU5 ELISA was shown to detect the majority of infected animals and, when applied in a molecular epidemiological context, to permit rapid phylogenetic classification of the infecting virus...
  40. Gjerset B, Rimstad E, Teige J, Soetaert K, Jonassen C. Impact of natural sheep-goat transmission on detection and control of small ruminant lentivirus group C infections. Vet Microbiol. 2009;135:231-8 pubmed publisher
    ..As sheep and goats may serve as reservoirs for all SRLV genogroup types, successful control programmes require inclusion of both species...
  41. Goedert J. Vertical transmission of human immunodeficiency virus type 1: insights from studies of multiple pregnancies. Acta Paediatr Suppl. 1997;421:56-9 pubmed
  42. Keen J, Hungerford L, Littledike E, Wittum T, Kwang J. Effect of ewe ovine lentivirus infection on ewe and lamb productivity. Prev Vet Med. 1997;30:155-69 pubmed
  43. Knowles D, Evermann J, Shropshire C, VanderSchalie J, Bradway D, Gezon H, et al. Evaluation of agar gel immunodiffusion serology using caprine and ovine lentiviral antigens for detection of antibody to caprine arthritis-encephalitis virus. J Clin Microbiol. 1994;32:243-5 pubmed
    ..56. The AGID test with either antigen was 100% specific. The lower sensitivity of the OPPV AGID test in detecting caprine antibody to CAEV indicates that OPPV antigen is of limited value for use in CAEV diagnosis and control programs...
  44. Rolland M, Mooney J, Valas S, Perrin G, Mamoun R. Characterisation of an Irish caprine lentivirus strain--SRLV phylogeny revisited. Virus Res. 2002;85:29-39 pubmed
    ..Our new sequences confirm the complex situation in SRLV phylogeny but more sequences are needed to elucidate more precisely the relationship between SRLV...
  45. Mwaengo D, Grant R, DeMartini J, Carlson J. Envelope glycoprotein nucleotide sequence and genetic characterization of North American ovine lentiviruses. Virology. 1997;238:135-44 pubmed
  46. Rosati S, Kwang J, Keen J. Genome analysis of North American small ruminant lentiviruses by polymerase chain reaction and restriction enzyme analysis. J Vet Diagn Invest. 1995;7:437-43 pubmed
    ..All strains were detected by LTR primers. Restriction endonuclease analysis of 5 amplified p25 and 2 N'-gp40 gene fragments revealed extensive heterogeneity among these North American small ruminant lentiviruses...