feline immunodeficiency virus

Summary

Summary: A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There are 3 strains: Petaluma (FIP-P), Oma (FIP-O) and Puma lentivirus (PLV). There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells.

Top Publications

  1. Franklin S, Kays R, Moreno R, Terwee J, Troyer J, Vandewoude S. Ocelots on Barro Colorado Island are infected with feline immunodeficiency virus but not other common feline and canine viruses. J Wildl Dis. 2008;44:760-5 pubmed
    ..feline calicivirus, feline corona virus, feline panleukopenia virus, canine distemper virus, and feline immunodeficiency virus (FIV), typically a species-specific infection...
  2. Hayward J, Rodrigo A. Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus). Vet Immunol Immunopathol. 2010;134:68-74 pubmed publisher
    Studying the evolutionary mechanisms of feline immunodeficiency virus in the domestic cat (Felis catus), FIV(Fca), provides a good comparison to other lentiviruses, such as HIV and FIV(Pco) in the cougar (Puma concolor)...
  3. Yamamoto J, Pu R, Sato E, Hohdatsu T. Feline immunodeficiency virus pathogenesis and development of a dual-subtype feline-immunodeficiency-virus vaccine. AIDS. 2007;21:547-63 pubmed
  4. Auwerx J, Esnouf R, De Clercq E, Balzarini J. Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors. Mol Pharmacol. 2004;65:244-51 pubmed
    To map the determinants of the lack of susceptibility of feline immunodeficiency virus (FIV) reverse transcriptase (RT) to anti human immunodeficiency virus type 1 (HIV-1) non-nucleoside RT inhibitors (NNRTIs), a variety of chimeric HIV-..
  5. Loewen N, Barraza R, Whitwam T, Saenz D, Kemler I, Poeschla E. FIV Vectors. Methods Mol Biol. 2003;229:251-71 pubmed
  6. Celma C, Paladino M, Gonz lez S, Affranchino J. Importance of the short cytoplasmic domain of the feline immunodeficiency virus transmembrane glycoprotein for fusion activity and envelope glycoprotein incorporation into virions. Virology. 2007;366:405-14 pubmed publisher
    ..b>Feline immunodeficiency virus (FIV) possesses a TM glycoprotein with a cytoplasmic tail of approximately 53 amino acids which is ..
  7. Endo Y, Uema M, Miura R, Tsukiyama Kohara K, Tsujimoto H, Yoneda K, et al. Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions (Panthera leo) in Japan. J Vet Med Sci. 2004;66:1587-9 pubmed
    Sero-prevalences of canine distemper virus (CDV), feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) were evaluated in 20 captive lions in two Japanese zoos. Anti-CDV antibody was detected in 13 of 20 lions...
  8. Hayward J, Taylor J, Rodrigo A. Phylogenetic analysis of feline immunodeficiency virus in feral and companion domestic cats of New Zealand. J Virol. 2007;81:2999-3004 pubmed
    Nested PCR was used to amplify envelope V3-V6 gene fragments of feline immunodeficiency virus (FIV) from New Zealand cats...
  9. Willett B, Hosie M. Chemokine receptors and co-stimulatory molecules: unravelling feline immunodeficiency virus infection. Vet Immunol Immunopathol. 2008;123:56-64 pubmed publisher
    b>Feline immunodeficiency virus (FIV) infection of the domestic cat induces an immunodeficiency characterised by a gradual depletion of CD4+ T-helper lymphocytes...

More Information

Publications99

  1. Sandy J, Robinson W, Bredhauer B, Kyaw Tanner M, Howlett C. Productive infection of the bone marrow cells in feline immunodeficiency virus infected cats. Arch Virol. 2002;147:1053-9 pubmed
    Bone marrow stromal cells (BMSC) from cats experimentally infected with feline immunodeficiency virus (FIV) were shown to contain FIV provirus using polymerase chain reaction and viral products were detected in culture supernatant using ..
  2. McEwan W, McMonagle E, Logan N, Serra R, Kat P, Vandewoude S, et al. Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors. J Virol. 2008;82:10953-8 pubmed publisher
    The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a ..
  3. Willett B, McMonagle E, Ridha S, Hosie M. Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus. J Virol. 2006;80:3386-94 pubmed
    The feline homologue of CD134 (fCD134) is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells...
  4. Kanzaki L, Looney D. Feline immunodeficiency virus: a concise review. Front Biosci. 2004;9:370-7 pubmed
    Among non-primate vertebrates, feline immunodeficiency virus (FIV) infection in the cat may be the closest model of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS)...
  5. Willett B, Cannon C, Hosie M. Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus. J Virol. 2002;76:9242-52 pubmed
    ..from a retrovirus vector, indicating that experiments investigating the effect of CCR5 expression on feline immunodeficiency virus (FIV) infection must be interpreted with caution...
  6. Price M, Case S, Carbonaro D, Yu X, Petersen D, Sabo K, et al. Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells. Mol Ther. 2002;6:645-52 pubmed
    Vectors based on the feline immunodeficiency virus (FIV) have been developed as an alternative to those based on another lentivirus, human immunodeficiency virus-1 (HIV-1), because of theoretical safety advantages...
  7. Meeker R. Feline immunodeficiency virus neuropathogenesis: from cats to calcium. J Neuroimmune Pharmacol. 2007;2:154-70 pubmed
    ..made from in vitro and in vivo studies on the infectious and pathological interactions of feline immunodeficiency virus (FIV) with the nervous system...
  8. Pistello M, Moscardini M, Mazzetti P, Bonci F, Zaccaro L, Isola P, et al. Development of feline immunodeficiency virus ORF-A (tat) mutants: in vitro and in vivo characterization. Virology. 2002;298:84-95 pubmed
    A functional ORF-A is essential for efficient feline immunodeficiency virus replication in lymphocytes...
  9. Dunham S. Lessons from the cat: development of vaccines against lentiviruses. Vet Immunol Immunopathol. 2006;112:67-77 pubmed
    b>Feline immunodeficiency virus (FIV) is a natural infection of domestic cats, which produces a disease with many similarities to human immunodeficiency virus (HIV) infection in man...
  10. Troyer J, Vandewoude S, Pecon Slattery J, McIntosh C, Franklin S, Antunes A, et al. FIV cross-species transmission: an evolutionary prospective. Vet Immunol Immunopathol. 2008;123:159-66 pubmed publisher
    ..These studies illustrate the utility of FIV as a model to discover the variables necessary for establishment and control of lentiviral infections in new species. ..
  11. Huisman W, Schrauwen E, Rimmelzwaan G, Osterhaus A. Intrahost evolution of envelope glycoprotein and OrfA sequences after experimental infection of cats with a molecular clone and a biological isolate of feline immunodeficiency virus. Virus Res. 2008;137:24-32 pubmed publisher
    b>Feline immunodeficiency virus (FIV) is a member of the genus Lentivirus and causes AIDS-like disease in its natural host, the cat...
  12. Levy J, Scott H, Lachtara J, Crawford P. Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity. J Am Vet Med Assoc. 2006;228:371-6 pubmed
    ..To determine seroprevalence of FeLV and FIV infection among cats in North America and risk factors for seropositivity...
  13. Boudreaux C, Lockett N, Chemerys D, Clay B, Scott V, Willeford B, et al. Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation. Vet Immunol Immunopathol. 2009;131:290-7 pubmed publisher
    ..However, maternal virological and hematological characteristics did not correlate either positively or negatively with reproductive outcome...
  14. Garg H, Fuller F, Tompkins W. Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion. Virology. 2004;321:274-86 pubmed
    b>Feline immunodeficiency virus (FIV) shares remarkable homology to primate lentiviruses, human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV)...
  15. Bruen T, Poss M. Recombination in feline immunodeficiency virus genomes from naturally infected cougars. Virology. 2007;364:362-70 pubmed
    ..use a recently developed statistical test to perform exploratory analysis of recombination in fourteen feline immunodeficiency virus (FIVpco) genomes derived from a wild population of cougars...
  16. Quimby J, Elston T, Hawley J, Brewer M, Miller A, Lappin M. Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. J Feline Med Surg. 2008;10:66-72 pubmed
    ..Serum was tested for feline leukemia virus (FeLV) antigen and antibodies against feline immunodeficiency virus, feline calicivirus (FCV), feline herpesvirus 1 (FHV-1), and Bartonella species (enzyme-linked ..
  17. Shimojima M, Miyazawa T, Ikeda Y, McMonagle E, Haining H, Akashi H, et al. Use of CD134 as a primary receptor by the feline immunodeficiency virus. Science. 2004;303:1192-5 pubmed publisher
    b>Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor...
  18. Pistello M, Bonci F, Flynn J, Mazzetti P, Isola P, Zabogli E, et al. AIDS vaccination studies with an ex vivo feline immunodeficiency virus model: analysis of the accessory ORF-A protein and DNA as protective immunogens. J Virol. 2006;80:8856-68 pubmed
    ..We investigated the protective potential of the accessory protein ORF-A of feline immunodeficiency virus (FIV) in cats...
  19. Willett B, McMonagle E, Logan N, Samman A, Hosie M. A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction. Retrovirology. 2008;5:77 pubmed publisher
    b>Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry...
  20. de Parseval A, Ngo S, Sun P, Elder J. Factors that increase the effective concentration of CXCR4 dictate feline immunodeficiency virus tropism and kinetics of replication. J Virol. 2004;78:9132-43 pubmed publisher
    The surface glycoprotein (gp95) of the feline immunodeficiency virus (FIV) binds in a strain-specific manner to several cell surface molecules, including CXCR4, heparan sulfate proteoglycans (HSPGs), DC-SIGN, and a 43-kDa cell surface ..
  21. Weaver E, Collisson E, Slater M, Zhu G. Phylogenetic analyses of Texas isolates indicate an evolving subtype of the clade B feline immunodeficiency viruses. J Virol. 2004;78:2158-63 pubmed
    Rigorous phylogenetic analyses were used to compare the nucleotide sequences of feline immunodeficiency virus strains isolated from Texas and throughout the world...
  22. Reggeti F, Bienzle D. Alloimmunity does not protect from challenge with the feline immunodeficiency virus. Vet Immunol Immunopathol. 2008;124:152-62 pubmed publisher
    ..of cats with allogeneic DC would induce immune responses that protect against challenge with the feline immunodeficiency virus. Two groups of 3 cats each received 3 subcutaneous injections of allogeneic or autologous DC, and were ..
  23. Gleich S, Hartmann K. Hematology and serum biochemistry of feline immunodeficiency virus-infected and feline leukemia virus-infected cats. J Vet Intern Med. 2009;23:552-8 pubmed publisher
    Hematological and biochemical values in cats naturally infected by feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV) are not completely documented.
  24. Burkala E, Poss M. Evolution of feline immunodeficiency virus Gag proteins. Virus Genes. 2007;35:251-64 pubmed
    ..NC is the only protein with evidence of positive selection, two of which occur in the N-terminal region responsible for RNA binding and interaction with host proteins...
  25. Vandewoude S, Apetrei C. Going wild: lessons from naturally occurring T-lymphotropic lentiviruses. Clin Microbiol Rev. 2006;19:728-62 pubmed
    ..more than 20 species of nondomestic felids and African hyenids demonstrate seroreactivity against feline immunodeficiency virus (FIV) antigens...
  26. Burkhard M, Valenski L, Leavell S, Dean G, Tompkins W. Evaluation of FIV protein-expressing VEE-replicon vaccine vectors in cats. Vaccine. 2002;21:258-68 pubmed
    Venezuelan equine encephalitis (VEE) virus-replicon particles (VRP) were used to generate feline immunodeficiency virus (FIV) Gag- and ENV-expressing vaccine vectors...
  27. Uckun F, Chen C, Samuel P, Pendergrass S, Venkatachalam T, Waurzyniak B, et al. In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats. Antimicrob Agents Chemother. 2003;47:1233-40 pubmed
    ..reverse transcriptase inhibitor (NRTI) compound stampidine in cats chronically infected with feline immunodeficiency virus (FIV)...
  28. Esposito C, D Errico G, Armenante M, Giannecchini S, Bendinelli M, Rovero P, et al. Physicochemical characterization of a peptide deriving from the glycoprotein gp36 of the feline immunodeficiency virus and its lipoylated analogue in micellar systems. Biochim Biophys Acta. 2006;1758:1653-61 pubmed
    ..Furthermore, the data point out a peculiarity of interaction of the peptides with SDS as compared with DPC. ..
  29. Hosie M, Willett B, Klein D, Dunsford T, Cannon C, Shimojima M, et al. Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence. J Virol. 2002;76:6062-72 pubmed
    ..with the domestic cat have demonstrated that vaccinal immunity to infection can be induced against feline immunodeficiency virus (FIV); however, protection is largely restricted to laboratory strains of FIV and does not extend to ..
  30. Freer G, Matteucci D, Mazzetti P, Tarabella F, Catalucci V, Ricci E, et al. Evaluation of feline monocyte-derived dendritic cells loaded with internally inactivated virus as a vaccine against feline immunodeficiency virus. Clin Vaccine Immunol. 2008;15:452-9 pubmed publisher
  31. Burkhard M, Dean G. Transmission and immunopathogenesis of FIV in cats as a model for HIV. Curr HIV Res. 2003;1:15-29 pubmed
    The feline immunodeficiency virus (FIV) model provides a system to study lentivirus transmission, virus kinetics, pathogenesis, host responses, and immune dysfunction in a natural, out-bred host, under controlled conditions with specific-..
  32. Little S, Sears W, Lachtara J, Bienzle D. Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in Canada. Can Vet J. 2009;50:644-8 pubmed
    The purposes of this study were to determine the seroprevalence of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) infection among cats in Canada and to identify risk factors for seropositivity...
  33. Pedersen N, North T, Rigg R, Reading C, Higgins J, Leutenegger C, et al. 16alpha-Bromo-epiandrosterone therapy modulates experimental feline immunodeficiency virus viremia: initial enhancement leading to long-term suppression. Vet Immunol Immunopathol. 2003;94:133-48 pubmed
    ..derivative of the natural hormone dehyroepiandrosterone (DHEA), was evaluated for its effects on feline immunodeficiency virus (FIV) infection in experimental cats...
  34. Ignacio G, Nordone S, Howard K, Dean G. Toll-like receptor expression in feline lymphoid tissues. Vet Immunol Immunopathol. 2005;106:229-37 pubmed publisher
    ..Our objective is to determine whether feline immunodeficiency virus (FIV) infection affects TLR expression or function thereby resulting in innate immune dysfunction...
  35. Howard K, Reckling S, Egan E, Dean G. Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats. Retrovirology. 2010;7:2 pubmed publisher
    ..The objective of this study was to determine the acute effect of viral dose on mucosal leukocytes and associated innate and adaptive immune responses...
  36. Pecon Slattery J, Troyer J, Johnson W, O Brien S. Evolution of feline immunodeficiency virus in Felidae: implications for human health and wildlife ecology. Vet Immunol Immunopathol. 2008;123:32-44 pubmed publisher
  37. Muirden A. Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus and feline coronavirus in stray cats sent to an RSPCA hospital. Vet Rec. 2002;150:621-5 pubmed
    ..RSPCA veterinary hospital were tested for feline leukaemia virus (FeLV), feline coronavirus (FCoV) and feline immunodeficiency virus (FIV). The prevalence of FeLV was 3.5 per cent in all the cats, 1.4 per cent in healthy cats and 6...
  38. de Parseval A, Su S, Elder J, Lee B. Specific interaction of feline immunodeficiency virus surface glycoprotein with human DC-SIGN. J Virol. 2004;78:2597-600 pubmed
    ..Here, we report that human DC-SIGN also captures feline immunodeficiency virus via high-affinity (1 nM), Ca(2+)-dependent, D-mannose-inhibited binding to the major envelope ..
  39. Rogers A, Hoover E. Fetal feline immunodeficiency virus is prevalent and occult. J Infect Dis. 2002;186:895-904 pubmed
    The feline model of human acquired immune deficiency syndrome, feline immunodeficiency virus (FIV), was used to model maternal-to-fetal human immunodeficiency virus type 1 (HIV-1) transmission...
  40. Natoli E, Say L, Cafazzo S, Bonanni R, Schmid M, Pontier D. Bold attitude makes male urban feral domestic cats more vulnerable to Feline Immunodeficiency Virus. Neurosci Biobehav Rev. 2005;29:151-7 pubmed
    ..a high annual reproductive success but, on the other hand, to a high probability to be infected by the Feline Immunodeficiency Virus (FIV), a lethal disease caused by a retrovirus...
  41. Phadke A, de la Concha Bermejillo A, Wolf A, Andersen P, Baladandayuthapani V, Collisson E. Pathogenesis of a Texas feline immunodeficiency virus isolate: an emerging subtype of clade B. Vet Microbiol. 2006;115:64-76 pubmed
    We have recently provided evidence that Texas feline immunodeficiency virus (FIV-TX) isolates are an emerging subtype sharing a common ancestry with clade B isolates...
  42. Arjona A, Barquero N, Domenech A, Tejerizo G, Collado V, Toural C, et al. Evaluation of a novel nested PCR for the routine diagnosis of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV). J Feline Med Surg. 2007;9:14-22 pubmed
    Laboratory diagnosis of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) usually involves both viruses, as the clinical signs are similar and coinfection may occur...
  43. Steinrigl A, Klein D. Phylogenetic analysis of feline immunodeficiency virus in Central Europe: a prerequisite for vaccination and molecular diagnostics. J Gen Virol. 2003;84:1301-7 pubmed
    b>Feline immunodeficiency virus (FIV) is a worldwide-occurring lentivirus that severely impairs the immune function of infected domestic cats...
  44. Fogle J, Mexas A, Tompkins W, Tompkins M. CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism. AIDS Res Hum Retroviruses. 2010;26:201-16 pubmed publisher
    ..Using the feline immunodeficiency virus (FIV) model for human AIDS, we reported previously that CD4(+)CD25(+) Treg cells in both the acute and ..
  45. Hayes K, Koksoy S, Phipps A, Buck W, Kociba G, Mathes L. Lentivirus-specific cytotoxic T-lymphocyte responses are rapidly lost in thymectomized cats infected with feline immunodeficiency virus. J Virol. 2005;79:8237-42 pubmed
    ..ThX and mock-ThX cats were inoculated with feline immunodeficiency virus (FIV) and monitored for their FIV-specific CTL responses...
  46. Kann R, Kyaw Tanner M, Seddon J, Lehrbach P, Zwijnenberg R, Meers J. Molecular subtyping of feline immunodeficiency virus from domestic cats in Australia. Aust Vet J. 2006;84:112-6 pubmed
    To determine the prevalent subtypes of feline immunodeficiency virus (FIV) present in the domestic cat population of Australia.
  47. Saenz D, Poeschla E. FIV: from lentivirus to lentivector. J Gene Med. 2004;6 Suppl 1:S95-104 pubmed
    Molecular virological understanding of the feline immunodeficiency virus (FIV) life cycle is increasing, facilitating rational derivation of improved vectors from this non-primate lentivirus...
  48. George J, Rideout B, Griffey S, Pedersen N. Effect of preexisting FeLV infection or FeLV and feline immunodeficiency virus coinfection on pathogenicity of the small variant of Haemobartonella felis in cats. Am J Vet Res. 2002;63:1172-8 pubmed
    ..To investigate the effects of preexisting FeLV infection or FeLV and feline immunodeficiency (FIV) coinfection on the pathogenicity of the small variant of Haemobartonella felis (Hfsm, California variant) in cats...
  49. Pecon Slattery J, McCracken C, Troyer J, Vandewoude S, Roelke M, Sondgeroth K, et al. Genomic organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wild. BMC Genomics. 2008;9:66 pubmed publisher
    b>Feline immunodeficiency virus (FIV) naturally infects multiple species of cat and is related to human immunodeficiency virus in humans...
  50. Lin Y, Torbett B, Elder J. Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease. J Virol. 2010;84:6799-809 pubmed publisher
    b>Feline immunodeficiency virus (FIV) and human immunodeficiency virus type 1 (HIV-1) proteases (PRs) share only 23% amino acid identity and exhibit distinct specificities yet have very similar 3-dimensional structures...
  51. Fu S, Chen D, Mao X, Zhang N, Ding Y, Bromberg J. Feline immunodeficiency virus-mediated viral interleukin-10 gene transfer prolongs non-vascularized cardiac allograft survival. Am J Transplant. 2003;3:552-61 pubmed
    ..b>Feline immunodeficiency virus (FIV) can integrate into genomic DNA of nondividing cells, resulting in indefinite transgene ..
  52. Poss M, Idoine A, Ross H, Terwee J, Vandewoude S, Rodrigo A. Recombination in feline lentiviral genomes during experimental cross-species infection. Virology. 2007;359:146-51 pubmed
    Domestic cats develop an asymptomatic, productive infection with a feline immunodeficiency virus (PLV) derived from a naturally infected cougar (P. concolor)...
  53. Liu P, Hudson L, Tompkins M, Vahlenkamp T, Colby B, Rundle C, et al. Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery. J Neurovirol. 2006;12:294-306 pubmed
    Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection...
  54. SPRAGUE W, Robbiani M, Avery P, O Halloran K, Hoover E. Feline immunodeficiency virus dendritic cell infection and transfer. J Gen Virol. 2008;89:709-15 pubmed publisher
    b>Feline immunodeficiency virus (FIV) interacts with dendritic cells (DC) during initiation of infection, but whether DC support or transfer FIV infection remains unclear...
  55. Goldkamp C, Levy J, Edinboro C, Lachtara J. Seroprevalences of feline leukemia virus and feline immunodeficiency virus in cats with abscesses or bite wounds and rate of veterinarian compliance with current guidelines for retrovirus testing. J Am Vet Med Assoc. 2008;232:1152-8 pubmed publisher
  56. Savarino A, Pistello M, D Ostilio D, Zabogli E, Taglia F, Mancini F, et al. Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS. Retrovirology. 2007;4:79 pubmed
    Treatment of feline immunodeficiency virus (FIV) infection has been hampered by the absence of a specific combination antiretroviral treatment (ART)...
  57. Lin Y, Brik A, de Parseval A, Tam K, Torbett B, Wong C, et al. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. J Virol. 2006;80:7832-43 pubmed
    We have used feline immunodeficiency virus (FIV) protease (PR) as a mutational system to study the molecular basis of substrate-inhibitor specificity for lentivirus PRs, with a focus on human immunodeficiency virus type 1 (HIV-1) PR...
  58. Howard K, Burkhard M. Mucosal challenge with cell-associated or cell-free feline immunodeficiency virus induces rapid and distinctly different patterns of phenotypic change in the mucosal and systemic immune systems. Immunology. 2007;122:571-83 pubmed
    ..24 hr after vaginal exposure to in vitro equilibrated infectious doses of cell-associated or cell-free feline immunodeficiency virus, uninfected heterologous cells, or medium alone...
  59. Mikkelsen S, Reckling S, Egan E, Dean G. In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus. Virology. 2010;403:163-72 pubmed publisher
    ..Lentivirus-induced CD4(+)CD25(hi) Treg cells were first described in feline immunodeficiency virus (FIV)-infected cats...
  60. Dean G, Lavoy A, Burkhard M. Peptide mapping of feline immunodeficiency virus by IFN-gamma ELISPOT. Vet Immunol Immunopathol. 2004;100:49-59 pubmed
    ..To date, this assay has not been widely utilized in feline immunodeficiency virus (FIV) research...
  61. Mizuno T, Goto Y, Baba K, Momoi Y, Endo Y, Nishimura Y, et al. Quantitative analysis of Fas and Fas ligand mRNAs in a feline T-lymphoid cell line after infection with feline immunodeficiency virus and primary peripheral blood mononuclear cells obtained from cats infected with the virus. Vet Immunol Immunopathol. 2003;93:117-23 pubmed
    Apoptosis is frequently observed in feline lymphocytes in association with feline immunodeficiency virus (FIV) infection...
  62. Pu R, Coleman J, Coisman J, Sato E, Tanabe T, Arai M, et al. Dual-subtype FIV vaccine (Fel-O-Vax FIV) protection against a heterologous subtype B FIV isolate. J Feline Med Surg. 2005;7:65-70 pubmed
    ..were undertaken to determine whether the Fel-O-Vax FIV, a commercial dual-subtype (subtypes A and D) feline immunodeficiency virus (FIV) vaccine, is effective against a subtype B FIV isolate...
  63. Norelli S, El Daker S, D Ostilio D, Mele F, Mancini F, Taglia F, et al. Response of feline immunodeficiency virus (FIV) to tipranavir may provide new clues for development of broad-based inhibitors of retroviral proteases acting on drug-resistant HIV-1. Curr HIV Res. 2008;6:306-17 pubmed
    ..Widespread drug-resistance to PIs now invokes the possibility of rescuing feline immunodeficiency virus (FIV) as a model for PI treatment...
  64. Lehman T, O Halloran K, Fallon S, Habermann L, Campbell J, Nordone S, et al. Altered bone marrow dendritic cell cytokine production to toll-like receptor and CD40 ligation during chronic feline immunodeficiency virus infection. Immunology. 2009;126:405-12 pubmed publisher
    ..In this study, we examined the effect of chronic feline immunodeficiency virus (FIV) infection on DC cytokine production in response to microbial and T-cell stimulation...
  65. Kann R, Seddon J, Kyaw Tanner M, Meers J. Co-infection with different subtypes of feline immunodeficiency virus can complicate subtype assignment by phylogenetic analysis. Arch Virol. 2007;152:1187-93 pubmed
    Phylogenetic analyses of the V3-V5 region of the env gene are used to determine Feline immunodeficiency virus (FIV) subtypes but can be complicated by co-infection with different subtypes or the presence of recombinant subtypes...
  66. D Cruz O, Waurzyniak B, Uckun F. Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats. Antimicrob Agents Chemother. 2004;48:1082-8 pubmed
    ..WHI-07 was active against the feline immunodeficiency virus (FIV)...
  67. Huisman W, Schrauwen E, Pas S, Karlas J, Rimmelzwaan G, Osterhaus A. Antibodies specific for hypervariable regions 3 to 5 of the feline immunodeficiency virus envelope glycoprotein are not solely responsible for vaccine-induced acceleration of challenge infection in cats. J Gen Virol. 2004;85:1833-41 pubmed
    In a previous vaccination study in cats, the authors reported on accelerated feline immunodeficiency virus (FIV) replication upon challenge in animals vaccinated with a candidate envelope subunit vaccine...
  68. Dowling R, Bienzle D. Gene-expression changes induced by Feline immunodeficiency virus infection differ in epithelial cells and lymphocytes. J Gen Virol. 2005;86:2239-48 pubmed publisher
    Infection of cats with Feline immunodeficiency virus (FIV) is an important model for understanding comparative lentivirus biology...
  69. Hu Q, Fink E, Hong Y, Wang C, Grant C, Elder J. Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein. PLoS ONE. 2010;5:e10689 pubmed publisher
    The chemokine receptor CXCR4 is shared by primary and laboratory-adapted strains of feline immunodeficiency virus (FIV) for viral entry...
  70. Huisman W, Schrauwen E, Pas S, van Amerongen G, Rimmelzwaan G, Osterhaus A. Evaluation of ISCOM-adjuvanted subunit vaccines containing recombinant feline immunodeficiency virus Rev, OrfA and envelope protein in cats. Vaccine. 2008;26:2553-61 pubmed publisher
    For the development of feline immunodeficiency virus (FIV) vaccines mostly structural proteins have been evaluated for their capacity to induce protective immunity...
  71. Terwee J, Carlson J, SPRAGUE W, Sondgeroth K, Shropshire S, Troyer J, et al. Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus. Virology. 2008;377:63-70 pubmed publisher
    ..These data provide support for the importance of non-adaptive enhancement of the immune response in the prevention of CD4+ T-cell loss...
  72. Auwerx J, North T, Preston B, Klarmann G, De Clercq E, Balzarini J. Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2002;61:400-6 pubmed
    ..acids lining the NNRTI-specific pocket of HIV-1 RT display higher similarity to the corresponding feline immunodeficiency virus (FIV) RT amino acids than to HIV-2 RT, the susceptibility of FIV RT and chimeric HIV-1/FIV RTs to ..
  73. Ravi M, Wobeser G, Taylor S, Jackson M. Naturally acquired feline immunodeficiency virus (FIV) infection in cats from western Canada: Prevalence, disease associations, and survival analysis. Can Vet J. 2010;51:271-6 pubmed
    This retrospective study evaluated epidemiologic features and disease associations of feline immunodeficiency virus (FIV) infection in client owned cats from western Canada. Among 1205 cats that were tested 66 (5...
  74. Brooks A, Stein C, Hughes S, Heth J, McCray P, Sauter S, et al. Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proc Natl Acad Sci U S A. 2002;99:6216-21 pubmed
    ..When recombinant feline immunodeficiency virus (FIV)-based vectors expressing beta-glucuronidase were unilaterally injected into the striatum of ..
  75. Hosie M, Beatty J. Vaccine protection against feline immunodeficiency virus. Aust Vet J. 2007;85:302-3 pubmed
  76. Levy J, Edinboro C, Glotfelty C, Dingman P, West A, Kirkland Cady K. Seroprevalence of Dirofilaria immitis, feline leukemia virus, and feline immunodeficiency virus infection among dogs and cats exported from the 2005 Gulf Coast hurricane disaster area. J Am Vet Med Assoc. 2007;231:218-25 pubmed
    ..To determine seroprevalence of dirofilariasis in dogs and seroprevalences of dirofilariasis, FeLV infection, and FIV infection in cats exported from the Gulf Coast region following the 2005 hurricanes...
  77. Norris J, Bell E, Hales L, Toribio J, White J, Wigney D, et al. Prevalence of feline immunodeficiency virus infection in domesticated and feral cats in eastern Australia. J Feline Med Surg. 2007;9:300-8 pubmed
    ..in eastern Australia, were collected over a 2-year period and tested for antibodies directed against feline immunodeficiency virus (FIV) using immunomigration (Agen FIV Rapid Immunomigration test) and enzyme-linked immunosorbent ..
  78. Sauter S, Gasmi M. FIV vector systems. Somat Cell Mol Genet. 2001;26:99-129 pubmed
    Why is feline immunodeficiency virus (FIV) such an appealing candidate for gene therapy vector development? Phylogenetic analysis suggests FIV is only distantly related to the primate lentiviruses, and despite repeated exposure, neither ..
  79. Willett B, McMonagle E, Bonci F, Pistello M, Hosie M. Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus. J Virol. 2006;80:7744-7 pubmed
    The feline homologue of CD134 is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells...
  80. de Monte M, Nonnenmacher H, Brignon N, Ullmann M, Martin J. A multivariate statistical analysis to follow the course of disease after infection of cats with different strains of the feline immunodeficiency virus (FIV). J Virol Methods. 2002;103:157-70 pubmed
    ..from each of a dozen of variables measured in five groups of three cats infected by five isolates of feline immunodeficiency virus (FIV)...
  81. Lee I, Levy J, Gorman S, Crawford P, Slater M. Prevalence of feline leukemia virus infection and serum antibodies against feline immunodeficiency virus in unowned free-roaming cats. J Am Vet Med Assoc. 2002;220:620-2 pubmed
    To determine prevalence of FeLV infection and serum antibodies against feline immunodeficiency virus (FIV) in unowned free-roaming cats.
  82. Pistello M, Bonci F, Zabogli E, Conti F, Freer G, Maggi F, et al. Env-expressing autologous T lymphocytes induce neutralizing antibody and afford marked protection against feline immunodeficiency virus. J Virol. 2010;84:3845-56 pubmed publisher
    ..a novel prime-boost approach, specific-pathogen-free cats were primed with a plasmid expressing Env of feline immunodeficiency virus (FIV) and feline granulocyte-macrophage colony-stimulating factor and then boosted with their own T ..
  83. Gemeniano M, Sawai E, Leutenegger C, Sparger E. Feline immunodeficiency virus ORF-Ais required for virus particle formation and virus infectivity. J Virol. 2003;77:8819-30 pubmed
    The orf-A (orf-2) gene of feline immunodeficiency virus (FIV) is a small open reading frame predicted to encode a 77-amino-acid protein that contains putative domains similar to those of the ungulate lentiviral Tat protein...
  84. Freer G, Matteucci D, Mazzetti P, Tarabella F, Ricci E, Bozzacco L, et al. Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course. Retrovirology. 2008;5:33 pubmed publisher
    Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed...
  85. Howard K, Burkhard M. FIV infection induces unique changes in phenotype and cellularity in the medial iliac lymph node and intestinal IEL. AIDS Res Hum Retroviruses. 2007;23:720-8 pubmed
    ..Our preliminary data in the feline immunodeficiency virus (FIV) animal model suggested additional changes in IEL, and marked differences in the responses of ..
  86. Shen X, Leutenegger C, Stefano Cole K, Pedersen N, Sparger E. A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens. J Gen Virol. 2007;88:2793-9 pubmed
    ..attenuation associated with a vif mutation by inoculation of newborn kittens with a vif-deleted feline immunodeficiency virus provirus plasmid (FIV-pPPRDeltavif)...
  87. Saenz D, Teo W, Olsen J, Poeschla E. Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. J Virol. 2005;79:15175-88 pubmed
    ..We compared feline immunodeficiency virus (FIV) to other restricted (human immunodeficiency virus type 1 [HIV-1], equine infectious anemia virus ..
  88. Nakamura K, Suzuki Y, Ikeo K, Ikeda Y, Sato E, Nguyen N, et al. Phylogenetic analysis of Vietnamese isolates of feline immunodeficiency virus: genetic diversity of subtype C. Arch Virol. 2003;148:783-91 pubmed
    Phylogenetic relationships of novel Vietnamese strains of feline immunodeficiency virus (FIV) were analysed...
  89. Mizukoshi F, Baba K, Horiuchi H, Goto Koshino Y, Setoguchi Mukai A, Fujino Y, et al. Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus. J Vet Med Sci. 2009;71:865-71 pubmed
    ..To develop a DC-based immunotherapy for feline immunodeficiency virus (FIV) infection, we carried out a study to characterize DCs from FIV-infected cats and compared the ..
  90. Assogba B, Leavell S, Porter K, Burkhard M. Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency. J Infect Dis. 2007;195:1184-8 pubmed
    ..To develop an animal model of host latency, cats were mucosally challenged with 10(2)-10(6) feline immunodeficiency virus (FIV)-infected T cells...