bovine immunodeficiency virus

Summary

Summary: The type species of LENTIVIRUS, subgenus bovine lentiviruses (LENTIVIRUSES, BOVINE), found in cattle and causing lymphadenopathy, LYMPHOCYTOSIS, central nervous system lesions, progressive weakness, and emaciation. It has immunological cross-reactivity with other lentiviruses including HIV.

Top Publications

  1. Meas S, Usui T, Ohashi K, Sugimoto C, Onuma M. Vertical transmission of bovine leukemia virus and bovine immunodeficiency virus in dairy cattle herds. Vet Microbiol. 2002;84:275-82 pubmed
    Vertical transmission of bovine leukemia virus (BLV) and bovine immunodeficiency virus (BIV) was investigated in five dairy cattle herds in Hokkaido, where 36.1 and 17.0% of cattle were BLV and BIV seropositive, respectively, and 9...
  2. St Louis M, Cojocariu M, Archambault D. The molecular biology of bovine immunodeficiency virus: a comparison with other lentiviruses. Anim Health Res Rev. 2004;5:125-43 pubmed
    b>Bovine immunodeficiency virus (BIV) was first isolated in 1969 from a cow, R-29, with a wasting syndrome. The virus isolated induced the formation of syncytia in cell cultures and was structurally similar to maedi-visna virus...
  3. Berkowitz R, Ilves H, Lin W, Eckert K, Coward A, Tamaki S, et al. Construction and molecular analysis of gene transfer systems derived from bovine immunodeficiency virus. J Virol. 2001;75:3371-82 pubmed
    ..To avoid this concern, we have constructed gene transfer systems based on a nonprimate lentivirus, bovine immunodeficiency virus. A panel of vectors and packaging constructs was generated and analyzed in a transient expression ..
  4. McNab T, Desport M, Dobson R, Tenaya I, Hartaningsih N, Wilcox G. Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus. Virology. 2010;404:261-8 pubmed publisher
    ..bovine lentiviruses, the acutely pathogenic Jembrana disease virus (JDV) and the non-pathogenic Bovine immunodeficiency virus (BIV) has not been reported although both JDV and a BIV-like virus have been reported in the Bali ..
  5. Ferens W, Hovde C. The non-toxic A subunit of Shiga toxin type 1 prevents replication of bovine immunodeficiency virus in infected cells. Virus Res. 2007;125:29-41 pubmed
    ..purpose of the present study was to characterize StxA1 activity against a second bovine retrovirus, bovine immunodeficiency virus (BIV)...
  6. Usui T, Meas S, Konnai S, Ohashi K, Onuma M. Seroprevalence of bovine immunodeficiency virus and bovine leukemia virus in dairy and beef cattle in hokkaido. J Vet Med Sci. 2003;65:287-9 pubmed
    Serological survey of bovine immunodeficiency virus (BIV) and bovine leukemia virus (BLV) infection was conducted in dairy cattle from 10 different regions of Hokkaido, Japan. Among 390 cattle, 11.0% of cattle were BIV-seropositive and 3...
  7. Yesilbag K, Yilmaz Z, Gungor B. Prevalence of antibodies to bovine respiratory viruses in cattle infected with bovine immunodeficiency virus. Vet Rec. 2008;162:660-1 pubmed
  8. Gomez Corredor A, Archambault D. The bovine immunodeficiency virus rev protein: identification of a novel lentiviral bipartite nuclear localization signal harboring an atypical spacer sequence. J Virol. 2009;83:12842-53 pubmed publisher
    The bovine immunodeficiency virus (BIV) Rev protein (186 amino acids [aa] in length) is involved in the nuclear exportation of partially spliced and unspliced viral RNAs...
  9. Carpenter S, Vaughn E, Yang J, Baccam P, Roth J, Wannemuehler Y. Antigenic and genetic stability of bovine immunodeficiency virus during long-term persistence in cattle experimentally infected with the BIV(R29) isolate. J Gen Virol. 2000;81:1463-72 pubmed
    Experimental infection of cattle with bovine immunodeficiency virus (BIV) is characterized by persistent, low levels of virus replication in the absence of clinical disease...

More Information

Publications87

  1. Yao X, Su Y, Liu C, Tan J, Liu L, Geng Y, et al. Establishment of an indicator cell line for monitoring bovine immunodeficiency virus infection and inhibitor susceptibility. J Virol Methods. 2010;163:25-30 pubmed publisher
    ..In order to monitor infection with bovine immunodeficiency virus (BIV) in vitro, an indicator cell line derived from baby hamster kidney cells which contains ..
  2. Corredor A, St Louis M, Archambault D. Molecular and biological aspects of the bovine immunodeficiency virus. Curr HIV Res. 2010;8:2-13 pubmed
    The bovine immunodeficiency virus (BIV) was isolated in 1969 from a cow, R-29, with a wasting syndrome suggesting bovine leucosis. The virus, first designated bovine visna-like virus, remained unstudied until HIV was discovered in 1983...
  3. Su Y, Qiao W, Guo T, Tan J, Li Z, Chen Y, et al. Microtubule-dependent retrograde transport of bovine immunodeficiency virus. Cell Microbiol. 2010;12:1098-107 pubmed publisher
    ..In this study, we found that pharmacological disruption of microtubules remarkably blocked bovine immunodeficiency virus (BIV) movement from the cell periphery to the perinuclear region, a process known as retrograde ..
  4. Meas S, Ruas J, Farias N, Usui T, Teraoka Y, Mulenga A, et al. Seroprevalence and molecular evidence for the presence of bovine immunodeficiency virus in Brazilian cattle. Jpn J Vet Res. 2002;50:9-16 pubmed
    Data on the worldwide distribution of bovine immunodeficiency virus (BIV) and bovine leukemia virus (BLV) is limited. A prevalence study of antibodies to BIV and BLV was conducted in six different cattle herds in Brazil...
  5. Calabro V, Daugherty M, Frankel A. A single intermolecular contact mediates intramolecular stabilization of both RNA and protein. Proc Natl Acad Sci U S A. 2005;102:6849-54 pubmed
    ..from the Jembrana disease virus (JDV) Tat protein is a structural "chameleon" that binds bovine immunodeficiency virus (BIV) or HIV TAR RNAs in two different binding modes, with an affinity for BIV TAR even higher than ..
  6. Gonzalez E, Licursi M, Vila Roza V, Bonzo E, Mortola E, Frossard J, et al. Evidence of bovine immunodeficiency virus (BIV) infection: serological survey in Argentina. Res Vet Sci. 2008;85:353-8 pubmed
    This is the first report of serological evidence for bovine immunodeficiency virus (BIV) infection in Argentina...
  7. Athanassiou Z, Patora K, Dias R, Moehle K, Robinson J, Varani G. Structure-guided peptidomimetic design leads to nanomolar beta-hairpin inhibitors of the Tat-TAR interaction of bovine immunodeficiency virus. Biochemistry. 2007;46:741-51 pubmed
    ..viral protein-RNA interactions, we recently identified inhibitors of the viral Tat protein from the bovine immunodeficiency virus (BIV) using conformationally constrained beta-hairpin peptidomimetics...
  8. Avidan O, Bochner R, Hizi A. The catalytic properties of the recombinant reverse transcriptase of bovine immunodeficiency virus. Virology. 2006;351:42-57 pubmed publisher
    b>Bovine immunodeficiency virus (BIV) is a lentivirus with no proven pathogenesis in infected cattle. Yet, in experimentally infected rabbits, it causes an AIDS-like disease...
  9. Lew A, Bock R, Miles J, Cuttell L, Steer P, Nadin Davis S. Sensitive and specific detection of bovine immunodeficiency virus and bovine syncytial virus by 5' Taq nuclease assays with fluorescent 3' minor groove binder-DNA probes. J Virol Methods. 2004;116:1-9 pubmed
    ..compared to conventional PCR assays for the sensitive detection of bovine syncytial virus (BSV) and bovine immunodeficiency virus (BIV). Seven beef and dairy herds were screened to evaluate these tests...
  10. Tok J, Bi L, Huang S. A comparative binding study of modified bovine immunodeficiency virus TAR RNA against its TAT peptide. Bioorg Med Chem Lett. 2004;14:6101-5 pubmed
    ..Herein, the synthesis and binding studies of a series of both wt and mutant bovine immunodeficiency virus (BIV) TAR RNA constructs against its Tat peptide are reported...
  11. Reyes C, Nifosì R, Frankel A, Kollman P. Molecular dynamics and binding specificity analysis of the bovine immunodeficiency virus BIV Tat-TAR complex. Biophys J. 2001;80:2833-42 pubmed
    ..binding specificity analyses using combined molecular mechanics and continuum solvent (MM-PBSA) on the bovine immunodeficiency virus (BIV) Tat peptide-TAR RNA complex...
  12. Tobin G, Ennis W, Clanton D, Gonda M. Inhibition of bovine immunodeficiency virus by anti-HIV-1 compounds in a cell culture-based assay. Antiviral Res. 1996;33:21-31 pubmed
    The bovine immunodeficiency virus (BIV) and human immunodeficiency virus types 1 and 2 (HIV-1 and -2) are members of the lentivirus genus of retroviruses...
  13. Matukonis M, Li M, Molina R, Paszkiet B, Kaleko M, Luo T. Development of second- and third-generation bovine immunodeficiency virus-based gene transfer systems. Hum Gene Ther. 2002;13:1293-303 pubmed
    ..An early-generation gene transfer system developed from bovine immunodeficiency virus (BIV) has been described (Berkowitz et al., J. Virol. 2001;75:3371-3382)...
  14. Cojocariu M, St Louis M, Archambault D. Bovine immunodeficiency virus: identification of a long terminal repeat sequence with enhanced promoter activity. Arch Virol. 2009;154:1163-7 pubmed publisher
    We previously identified a new bovine immunodeficiency virus (BIV) trans-activator factor of transcription (Tat236) that was derived from a variant of BIV...
  15. Setiyaningsih S, Desport M, Stewart M, Hartaningsih N, Wilcox G. Sequence analysis of mRNA transcripts encoding Jembrana disease virus Tat-1 in vivo. Virus Res. 2008;132:220-5 pubmed
    ..Sequence conservation in the regions of tat-1 that are critical for RNA binding and transcription activation in three different virus strains was high and the tat-2 sequences were completely conserved...
  16. Avidan O, Hizi A. Expression and characterization of the integrase of bovine immunodeficiency virus. Virology. 2008;371:309-21 pubmed publisher
    In the pol gene of bovine immunodeficiency virus (BIV) there is a sequence, located between the reverse-transcriptase and integrase (IN)-encoding sequences, that is not found in HIV-1 pol gene and encodes a 74-residue polypeptide with ..
  17. Jing H, Lin X, Xu L, Gao L, Zhang M, Wang N, et al. Establishment and characterization of a heart-derived cell line from goldfish (Carassius auratus). Fish Physiol Biochem. 2017;43:977-986 pubmed publisher
    ..These results suggest that the GH cell line is a valuable tool for studying viral pathogenesis. ..
  18. Spotin A, Karamat M, Mahami Oskouei M, Shahbazi A, Ahmadpour E, Galeh T, et al. Genetic variability and transcontinental sharing of Giardia duodenalis infrapopulations determined by glutamate dehydrogenase gene. Acta Trop. 2018;177:146-156 pubmed publisher
    ..The current findings strengthen our knowledge to assess the evolutionary patterns of G. duodenalis in endemic foci of the world and it will become the basis of public health policy to control human giardiasis. ..
  19. Hernández Madrid A, Facchin D, Klepfer R, Ghosh S, Matía R, Moreno J, et al. Device pacing diagnostics overestimate effective cardiac resynchronization therapy pacing results of the hOLter for Efficacy analysis of CRT (OLÉ CRT) study. Heart Rhythm. 2017;14:541-547 pubmed publisher
    ..The new algorithm quantifies ineffective CRT pacing, which enables clinicians to identify patients with this issue and to address the reasons behind suboptimal CRT delivery. ..
  20. Fong S, Greenwood J, Williamson J, Derse D, Pallansch L, Copeland T, et al. Bovine immunodeficiency virus tat gene: cloning of two distinct cDNAs and identification, characterization, and immunolocalization of the tat gene products. Virology. 1997;233:339-57 pubmed
    cDNAs encoding the bovine immunodeficiency virus (BIV) transactivator gene (tat) were cloned from virally infected cells and characterized...
  21. Zupančič O, Grießinger J, Lam H, Bernkop Schnürch A. Storage Stability of Bivalirudin: Hydrophilic Versus Lipophilic Solutions. J Pharm Sci. 2017;106:1322-1330 pubmed publisher
    ..According to these findings, SEDDS could be considered as a potential bivalirudin stabilization medium against chemical degradation. ..
  22. Åžipal A, Bozyel S, AktaÅŸ M, DerviÅŸ E, Akbulut T, Argan O, et al. Surface electrogram-guided left ventricular lead placement improves response to cardiac resynchronization therapy. Anatol J Cardiol. 2018;19:184-191 pubmed publisher
    ..70%, p=0.181). Surface ECG can be used to guide LV lead placement in patients with multiple target veins for improving response to CRT. Thus, it is a safe, feasible, and economic approach for CRT-D implantation. ..
  23. Runyon S, Puglisi J. Design of a cyclic peptide that targets a viral RNA. J Am Chem Soc. 2003;125:15704-5 pubmed
    ..A cyclic peptide analog of the RNA binding domain of the bovine immunodeficiency virus (BIV) Tat protein is shown to bind specifically to its target RNA stem loop...
  24. Scobie L, Venables C, Hughes K, Dawson M, Jarrett O. The antibody response of cattle infected with bovine immunodeficiency virus to peptides of the viral transmembrane protein. J Gen Virol. 1999;80 ( Pt 1):237-43 pubmed
    The development of the antibody response to peptides of the transmembrane glycoprotein of bovine immunodeficiency virus (BIV) was followed over a period of 50 weeks in six cattle experimentally infected with the BIV(FL112) isolate...
  25. Bernardi L, Frangipane F, Smirne N, Colao R, Puccio G, Curcio S, et al. Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in southern Italy. Neurobiol Aging. 2012;33:2948.e1-2948.e10 pubmed publisher
    ..We report an unusually high FTD prevalence in the investigated population, but a low prevalence of Alzheimer's disease. We confirm the heterogeneity of FTD phenotype associated with different GRN mutations. ..
  26. de Lucio A, Bailo B, Aguilera M, Cardona G, Fernández Crespo J, Carmena D. No molecular epidemiological evidence supporting household transmission of zoonotic Giardia duodenalis and Cryptosporidium spp. from pet dogs and cats in the province of Álava, Northern Spain. Acta Trop. 2017;170:48-56 pubmed publisher
    ..We conclude, therefore, that zoonotic transmission of giardiosis or cryptosporidiosis among pet dogs and cats and their owners in this geographical region is very likely a rare event. ..
  27. Skaf S, Thibault B, Khairy P, O Meara E, Fortier A, Vakulenko H, et al. Impact of Left Ventricular vs Biventricular Pacing on Reverse Remodelling: Insights From the Evaluation of Resynchronization Therapy for Heart Failure (EARTH) Trial. Can J Cardiol. 2017;33:1274-1282 pubmed publisher
    ..Analyses of secondary end points revealed advantages of BiV pacing over LV pacing on several other features of cardiac remodelling, providing mechanistic insights to support the main finding of the GREATER-EARTH trial. ..
  28. Hasan B, Lunze F, Alvi N, Shafer K, Rhodes J. Feasibility of exercise stress echocardiography and myocardial response in patients with repaired congenital heart disease. Am Heart J. 2017;188:1-10 pubmed publisher
    ..Although patients with BiV and UniV circulation had both preserved myocardial response to exercise, the magnitude of this response was the lowest in patients with UniV circulation. ..
  29. Yamada E, Yoshikawa R, Nakano Y, Misawa N, Kobayashi T, Ren F, et al. A naturally occurring bovine APOBEC3 confers resistance to bovine lentiviruses: implication for the co-evolution of bovids and their lentiviruses. Sci Rep. 2016;6:33988 pubmed publisher
    ..we address the co-evolutionary dynamics of bovine APOBEC3 and the following two bovine lentiviruses: bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV)...
  30. Daoud E. Cardiac resynchronization therapy is appropriate for all patients requiring chronic right ventricular pacing: the con perspective. Card Electrophysiol Clin. 2015;7:445-53 pubmed publisher
    ..This article summarizes the relevant studies demonstrating that BiV pacing is not appropriate therapy for all patients who require chronic RV pacing. ..
  31. Irisarri Gutiérrez M, Mingo M, de Lucio A, Gil H, Morales L, Seguí R, et al. Association between enteric protozoan parasites and gastrointestinal illness among HIV- and tuberculosis-infected individuals in the Chowke district, southern Mozambique. Acta Trop. 2017;170:197-203 pubmed publisher
    ..Based on their common presence in the studied clinical population, we recommend the effective diagnosis and treatment of these enteropathogens for improving the management of HIV and TB patients. ..
  32. Tretyakova I, Hidajat R, Hamilton G, Horn N, Nickols B, Prather R, et al. Preparation of quadri-subtype influenza virus-like particles using bovine immunodeficiency virus gag protein. Virology. 2016;487:163-71 pubmed publisher
    ..Here we demonstrated that influenza VLPs can be made in Sf9 cells by using the bovine immunodeficiency virus gag (Bgag) protein in place of M1...
  33. Molina R, Ye H, Brady J, Zhang J, Zimmerman H, Kaleko M, et al. A synthetic Rev-independent bovine immunodeficiency virus-based packaging construct. Hum Gene Ther. 2004;15:865-77 pubmed
    ..We previously developed second- and third-generation bovine immunodeficiency virus (BIV)-based gene transfer systems...
  34. Suarez D, Whetstone C. Size variation within the second hypervariable region of the surface envelope gene of the bovine lentivirus BIV in experimentally and naturally infected cattle. J Virol. 1997;71:2482-6 pubmed
    ..Similar to other lentiviruses, BIV appears to mutate rapidly, which may be important in viral persistence and pathogenesis. ..
  35. Li Y, Carpenter S. Cis-acting sequences may contribute to size variation in the surface glycoprotein of bovine immunodeficiency virus. J Gen Virol. 2001;82:2989-98 pubmed
    ..and insertion, has been observed during in vivo infection with several lentiviruses, including bovine immunodeficiency virus (BIV), equine infectious anaemia virus (EIAV) and human immunodeficiency virus type 1...
  36. Meas S, Kabeya H, Yoshihara S, Ohashi K, Matsuki S, Mikami Y, et al. Seroprevalence and field isolation of bovine immunodeficiency virus. J Vet Med Sci. 1998;60:1195-202 pubmed
    A seroprevalence study of bovine lentivirus, known as bovine immunodeficiency virus (BIV), was conducted in 12 different dairy herds in Hokkaido, where some herds were a high prevalence of bovine leukemia virus (BLV) infection...
  37. Xie B, Wainberg M, Frankel A. Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions. J Virol. 2003;77:1984-91 pubmed
    Human immunodeficiency viruses (HIVs) and the related bovine lentiviruses bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) utilize the viral Tat protein to activate viral transcription...
  38. Yang Y, Chen G, Dong W, Chen Q, Geng Y, Zeng Y. [Construction and analysis of activity of an HIV-1/bovine immunodeficiency virus chimeric clone cDNA]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003;17:143-5 pubmed
    Chimeric human/bovine immunodeficiency virus (HBIV) cDNA was constructed by replacing HIV tat and LTR with bovine immunodeficiency virus (BIV) tat and LTR to study the activity of BIV tat and LTR in the chimerae...
  39. de Oliveira C, Barbosa J, Damasceno K, Cassali G, Oliveira C, Leite R, et al. Multicentric lymphoma in buffaloes in the Amazon region, Brazil. BMC Vet Res. 2016;12:238 pubmed
    ..Bovine herpesvirus 6 was not detected in the tumors. However, Bovine immunodeficiency virus (BIV) was detected in samples of lymphoma and in the lymph nodes and kidneys of one of the animals...
  40. Ferens W, Halver M, Gustin K, Ott T, Hovde C. Differential sensitivity of viruses to the antiviral activity of Shiga toxin 1 A subunit. Virus Res. 2007;125:104-8 pubmed
    ..1 (StxA1) reduces expression and replication of the bovine retroviruses, bovine leukemia virus and bovine immunodeficiency virus (BIV)...
  41. Skhal D, Aboualchamat G, Al Mariri A, Al Nahhas S. Prevalence of Giardia duodenalis assemblages and sub-assemblages in symptomatic patients from Damascus city and its suburbs. Infect Genet Evol. 2017;47:155-160 pubmed publisher
    ..Further studies are needed to screen a wide geographic areas in Syria and to estimate the prevalence of G. duodenalis infection in our population. ..
  42. Bielanski A, Nadin Davis S, Simard C, Maxwell P, Algire J. Experimental collection and transfer of embryos from bovine immunodeficiency virus (BIV) infected cattle. Theriogenology. 2001;55:641-8 pubmed
    Three experiments were conducted to determine whether the lentivirus, bovine immunodeficiency virus (BIV) is likely to be transmitted via embryo transfer...
  43. Scholl D, Truax R, Baptista J, Ingawa K, Orr K, O Reilly K, et al. Natural transplacental infection of dairy calves with bovine immunodeficiency virus and estimation of effect on neonatal health. Prev Vet Med. 2000;43:239-52 pubmed
    Many experimental infection studies with bovine immunodeficiency virus (BIV) have been conducted, but neither virus transmission under natural conditions nor longitudinal clinical effects of naturally occurring infections in non-..
  44. Orr K, O Reilly K, Scholl D. Estimation of sensitivity and specificity of two diagnostics tests for bovine immunodeficiency virus using Bayesian techniques. Prev Vet Med. 2003;61:79-89 pubmed
    The validation of assays for bovine immunodeficiency virus (BIV) in cattle is hampered by the absence of a gold standard...
  45. Campisi D, Calabro V, Frankel A. Structure-based design of a dimeric RNA-peptide complex. EMBO J. 2001;20:178-86 pubmed
    The arginine-rich RNA-binding domain of bovine immunodeficiency virus (BIV) Tat adopts a beta-hairpin conformation upon binding to the major groove of BIV TAR...
  46. Desport M, Stewart M, Sheridan C, Ditcham W, Setiyaningsih S, Tenaya W, et al. Recombinant Jembrana disease virus gag proteins identify several different antigenic domains but do not facilitate serological differentiation of JDV and nonpathogenic bovine lentiviruses. J Virol Methods. 2005;124:135-42 pubmed
    ..Clin. Diagn. Lab. Immunol. 8, 283-287] was tested but was not recognised by either JDV positive sera from Jembrana disease-endemic or Jembrana disease-free areas...
  47. Kempster S, Collins M, Brownlie J. Tat protein expression in MDBK cells does not confer susceptibility to bovine immunodeficiency virus. Arch Virol. 2002;147:643-9 pubmed
    ..Whether viral entry into MDBK cells is also a block to BIV R29 infection of MDBK cells has yet to be established...
  48. Zheng L, Zhang S, Wood C, Kapil S, Wilcox G, Loughin T, et al. Differentiation of two bovine lentiviruses by a monoclonal antibody on the basis of epitope specificity. Clin Diagn Lab Immunol. 2001;8:283-7 pubmed
    b>Bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) are bovine lentiviruses that are closely related genetically...
  49. Snider T, Coats K, Storts R, Graves K, Cooper C, Hoyt P, et al. Natural bovine lentivirus type 1 infection in Holstein dairy cattle. II. Lymphoid tissue lesions. Comp Immunol Microbiol Infect Dis. 2003;26:1-15 pubmed
    b>Bovine immunodeficiency virus (BIV) in Holstein cows was associated with morphologic evidence of lymphoid organ deficiency...
  50. Tok J, Des Jean R, Fenker J. Binding of a cyclic BIV beta-Tat peptide with its TAR RNA construct. Bioorg Med Chem Lett. 2001;11:43-6 pubmed
  51. Xuan C, Qiao W, Li J, Peng G, Liu M, Chen Q, et al. BTat, a trans-acting regulatory protein, contributes to bovine immunodeficiency virus-induced apoptosis. Cell Microbiol. 2008;10:31-40 pubmed
    b>Bovine immunodeficiency virus (BIV) is a member of the lentivirus subfamily of retroviruses highly related to human immunodeficiency virus in morphologic, antigenic and genomic features...
  52. Kalvatchev Z, Walder R, Garzaro D, Barrios M. Detection of genetic diversity among bovine immunodeficiency virus population by single-strand conformation polymorphism analysis. Viral Immunol. 2000;13:373-81 pubmed
    ..These variations may relate to cell-type targets and/or disease progression, and could be significant to our understanding of lentiviral pathogenesis...
  53. Ramakrishnan S, Sukhaswami M, Patil K, Eswaran C. Sequence data analysis reveals a relationship between LSR2, the recombinant fusion protein mimicing M. Leprae and VIF of bovine immunodeficiency virus (BIV). J Biomol Struct Dyn. 1997;15:605-9 pubmed
    ..this 12 residue long peptide (T7) of LSR2 is homologous with Viral Infectivity Factor (VIF) of the Bovine Immunodeficiency Virus (BIV). Homology with translated nucleic acid sequence also indicate the same fact...
  54. Landt S, Tipton A, Frankel A. Localized influence of 2'-hydroxyl groups and helix geometry on protein recognition in the RNA major groove. Biochemistry. 2005;44:6547-58 pubmed
    ..It seems plausible that arginine-rich peptides are able to adapt to a mosaic helical architecture in which segments as small as single base steps may be considered as modular recognition units...
  55. Patel D. Adaptive recognition in RNA complexes with peptides and protein modules. Curr Opin Struct Biol. 1999;9:74-87 pubmed
    ..These alternative strategies of RNA recognition at the peptide and protein module level provide novel insights into the principles, patterns and diversity of the adaptive transitions associated with the recognition process...
  56. Gonzalez G, Johnston J, Nickel D, Jacobs R, Olson M, Power C. Very low prevalence of bovine immunodeficiency virus infection in western Canadian cattle. Can J Vet Res. 2001;65:73-6 pubmed
    b>Bovine immunodeficiency virus (BIV) is a lentivirus that causes disease in cattle. Despite the large cattle industry in western Canada, the presence of BIV has not been examined to date...
  57. Tok J, Bi L. A comparative binding study of BIV Tat peptide against its TAR RNA duplex, RNA-DNA heteroduplex and DNA duplex. Bioorg Med Chem Lett. 2005;15:129-33 pubmed
    ..It was observed that binding affinities of Tat peptide is comparable against DNA-RNA heteroduplex and RNA duplex, whereas DNA duplex binding is decidedly poor...
  58. Zhu Y, Liu C, Liu X, Qiao W, Chen Q, Zeng Y, et al. Construction and characterization of chimeric BHIV (BIV/HIV-1) viruses carrying the bovine immunodeficiency virus gag gene. World J Gastroenterol. 2005;11:2609-15 pubmed
    To explore the possibility of the replacement of the gag gene between human immunodeficiency virus and bovine immunodeficiency virus, to achieve chimeric virions, and thereby gain a new kind of AIDS vaccine based on BHIV chimeric viruses.
  59. Bielanski A, Simar C, Maxwell P, Nadin Davis S. Bovine immunodeficiency virus in relation to embryos fertilized in vitro. Vet Res Commun. 2001;25:663-73 pubmed
    The association of bovine immunodeficiency virus (BIV) with embryos derived by in vitro fertilization from oocytes of experimentally infected heifers or oocytes/embryos exposed to the virus in vitro was investigated...
  60. Chen G, Wang S, Xiong K, Wang J, Ye T, Dong W, et al. Construction and characterization of a chimeric virus (BIV/HIV-1) carrying the bovine immunodeficiency virus gag-pol gene. AIDS. 2002;16:123-5 pubmed
    ..The results firstly demonstrated that it is possible to generate a new type of the BIV/HIV-1 chimeric virus containing BIV gag-pol gene...
  61. Burkala E, Ellis T, Voigt V, Wilcox G. Serological evidence of an Australian bovine lentivirus. Vet Microbiol. 1999;68:171-7 pubmed
    Recombinant 26 kDa capsid (CA) proteins of bovine lentiviruses, bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV), were expressed in Escherichia coli and utilised as antigens for an enzyme-linked immunosorbent assay (..
  62. St Louis M, Abed Y, Archambault D. The bovine immunodeficiency virus: cloning of a tat/rev cDNA encoding a novel Tat protein with enhanced transactivation activity. Arch Virol. 2005;150:1529-47 pubmed
    ..This is the first report of a hybrid Tat protein from BIV or any lentiviruses that shows higher transactivation than the original transactivator Tat proteins...
  63. Liu C, Li X, Yao X, Kong X, Qiao W, Geng Y. Bovine ISG15: an antiviral and inducible protein in BIV infected fetal bovine lung cells. Virol J. 2010;7:134 pubmed publisher
    ..the properties of bISG15 capable of being inducible in fetal bovine lung (FBL) cells upon infection of bovine immunodeficiency virus (BIV) is of significant importance...
  64. Cherepanov P. LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro. Nucleic Acids Res. 2007;35:113-24 pubmed publisher
    ..In contrast, all lentiviral INs examined, including those from bovine immunodeficiency virus (BIV), maedi-visna virus (MVV) and equine infectious anemia virus (EIAV) readily interacted with LEDGF...
  65. Zhao X, Li M, Xu Y, Lou Z, Meng Z, Li S, et al. Cloning, expression, purification, crystallization and preliminary crystallographic study of the protein module (BIV2-Helix) in the fusion core of bovine immunodeficiency-like virus (BIV) gp40. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:249-51 pubmed
    The fusion core of bovine immunodeficiency virus (BIV) gp40 is proposed to be involved in membrane fusion. However, no crystal structures are yet available...
  66. Athanassiou Z, Dias R, Moehle K, Dobson N, Varani G, Robinson J. Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements. J Am Chem Soc. 2004;126:6906-13 pubmed
    An approach is described to the design of beta-hairpin peptidomimetic ligands for bovine immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response element (TAR) RNA...
  67. Bhatia S, Gangil R, Gupta D, Sood R, Pradhan H, Dubey S. Single-chain fragment variable antibody against the capsid protein of bovine immunodeficiency virus and its use in ELISA. J Virol Methods. 2010;167:68-73 pubmed publisher
    Recombinant antibody specific for the capsid (CA) protein of bovine immunodeficiency virus (BIV) was generated in the form of single-chain fragment variable (ScFv) using the phage display technique for affinity selection...
  68. Wright S, Mleczko A, Coats K. Bovine immunodeficiency virus expression in vitro is reduced in the presence of beta-chemokines, MIP-1alpha, MIP-1beta and RANTES. Vet Res Commun. 2002;26:239-50 pubmed
    ..b>Bovine immunodeficiency virus (BIV), a lentivirus, infects a wide variety of leukocyte populations, but the cellular receptor(s) ..
  69. Lu M, Zheng L, Mitchell K, Kapil S, Wood C, Minocha H. Unique epitope of bovine immunodeficiency virus gag protein spans the cleavage site between p16(MA) and p2L. Clin Diagn Lab Immunol. 2002;9:1277-81 pubmed
    b>Bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) are closely related bovine lentiviruses that are difficult to distinguish by presently available diagnostic methods...
  70. Molina R, Matukonis M, Paszkiet B, Zhang J, Kaleko M, Luo T. Mapping of the bovine immunodeficiency virus packaging signal and RRE and incorporation into a minimal gene transfer vector. Virology. 2002;304:10-23 pubmed
    ..An early generation of gene transfer system based on bovine immunodeficiency virus (BIV) has been developed (R. D. Berkowitz, H. Ilves, W. Y. Lin, K. Eckert, A. Coward, S. Tamaki, G...
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    A seroepidemiological study of bovine immunodeficiency virus (BIV) and bovine leukemia virus (BLV) infections was conducted in four different cattle herds in Turkey. A total of 300 blood samples were analyzed and 12...
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    b>Bovine Immunodeficiency Virus (BIV) is a nonacute, pathogenic, and horizontally transmitted lentivirus. It shares the parallel properties in morphology and genetics with human immunodeficiency virus type 1 and other lentiviruses...
  73. Wu D, Murakami K, Morooka A, Jin H, Inoshima Y, Sentsui H. In vivo transcription of bovine leukemia virus and bovine immunodeficiency-like virus. Virus Res. 2003;97:81-7 pubmed
    ..These results indicated that BLV can infect T cells and monocytes as well as B cells, but can be expressed by transcription only in B cells. In contrast, BIV can express its transcripts in all infected cells...
  74. Guo X, Hu J, Whitney J, Russell R, Liang C. Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag protein. J Virol. 2004;78:551-60 pubmed
    ..We have now extended this finding to the CA-NC spacer motif within the Gag protein of bovine immunodeficiency virus (BIV)...
  75. Lustig B, Bahar I, Jernigan R. RNA bulge entropies in the unbound state correlate with peptide binding strengths for HIV-1 and BIV TAR RNA because of improved conformational access. Nucleic Acids Res. 1998;26:5212-7 pubmed
    ..Nonetheless, this unusual effect is interesting...
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    A set of primers was developed to detect by polymerase chain reaction (PCR) the proviral DNA of bovine immunodeficiency virus (BIV)...
  77. Su Y, Deng G, Gai Y, Li Y, Gao Y, Du J, et al. Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters: evidence for flexibility at its N-terminus. Virol J. 2009;6:179 pubmed publisher
    ..Here, we compared the sequence requirements of jTat for transactivation of JDV, bovine immunodeficiency virus (BIV) and human immunodeficiency virus (HIV) LTRs.
  78. Bhatia S, Sood R, Bhatia A, Pattnaik B, Pradhan H. Development of a capsid based competitive inhibition enzyme-linked immunosorbent assay for detection of bovine immunodeficiency virus antibodies in cattle and buffalo serum. J Virol Methods. 2008;148:218-25 pubmed publisher
    ..inhibition ELISA (CI-ELISA) than the currently used indirect ELISA for detection of antibodies to bovine immunodeficiency virus (BIV) in cattle and buffaloes...