bovine lentiviruses

Summary

Summary: A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in cattle.

Top Publications

  1. Burkala E, Narayani I, Hartaningsih N, Kertayadnya G, Berryman D, Wilcox G. Recombinant Jembrana disease virus proteins as antigens for the detection of antibody to bovine lentiviruses. J Virol Methods. 1998;74:39-46 pubmed
  2. Yamada E, Yoshikawa R, Nakano Y, Misawa N, Kobayashi T, Ren F, et al. A naturally occurring bovine APOBEC3 confers resistance to bovine lentiviruses: implication for the co-evolution of bovids and their lentiviruses. Sci Rep. 2016;6:33988 pubmed publisher
    ..Here, we address the co-evolutionary dynamics of bovine APOBEC3 and the following two bovine lentiviruses: bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV)...
  3. Soeharsono S, Wilcox G, Putra A, Hartaningsih N, Sulistyana K, Tenaya M. The transmission of Jembrana disease, a lentivirus disease of Bos javanicus cattle. Epidemiol Infect. 1995;115:367-74 pubmed
  4. Mintern J, Guillonneau C. Frontiers in immunology research network--2008 International Conference. IDrugs. 2008;11:710-2 pubmed
  5. Barboni P, Thompson I, Brownlie J, Hartaningsih N, Collins M. Evidence for the presence of two bovine lentiviruses in the cattle population of Bali. Vet Microbiol. 2001;80:313-27 pubmed
    Antibodies directed against two bovine lentiviruses, Jembrana disease virus (JDV) and bovine immunodeficiency virus (BIV), were detected in Balinese cattle sera using two new enzyme-linked immunosorbent assays (ELISAs) based on the ..
  6. Ebrahimi B, Roy D, Bird P, Sargan D. Cloning, sequencing and expression of the ovine interleukin 6 gene. Cytokine. 1995;7:232-6 pubmed
    ..This is in contrast to recombinant human IL-6, which is capable of stimulating B9 cell proliferation, but not immunoglobulin production by ovine PBMC...
  7. Stewart M, Desport M, Hartaningsih N, Wilcox G. TaqMan real-time reverse transcription-PCR and JDVp26 antigen capture enzyme-linked immunosorbent assay to quantify Jembrana disease virus load during the acute phase of in vivo infection. J Clin Microbiol. 2005;43:5574-80 pubmed
    ..The relatively insensitive capture ELISA provides an economical and feasible method for monitoring of virus in the absence of more sensitive techniques...
  8. Suarez D, Whetstone C. Identification of hypervariable and conserved regions in the surface envelope gene in the bovine lentivirus. Virology. 1995;212:728-33 pubmed
    ..The four field isolates sequenced for this study had SU genes larger than R29-127. R29-derived isolates may not be representative of BIV currently present in United States cattle...
  9. Desport M, Lewis J. Jembrana disease virus: host responses, viral dynamics and disease control. Curr HIV Res. 2010;8:53-65 pubmed

More Information

Publications31

  1. Lewis J, McNab T, Tenaya M, Hartaningsih N, Wilcox G, Desport M. Comparison of immunoassay and real-time PCR methods for the detection of Jembrana disease virus infection in Bali cattle. J Virol Methods. 2009;159:81-6 pubmed publisher
    ..A combination of real-time PCR and JDV p26-his ELISA is recommended for the detection of infection with JDV in Indonesia...
  2. Ditcham W, Lewis J, Dobson R, Hartaningsih N, Wilcox G, Desport M. Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle. Virology. 2009;386:317-24 pubmed publisher
  3. Xuan C, Qiao W, Gao J, Liu M, Zhang X, Cao Y, et al. Regulation of microtubule assembly and stability by the transactivator of transcription protein of Jembrana disease virus. J Biol Chem. 2007;282:28800-6 pubmed
    ..These results not only identify Jtat as an important viral regulator of microtubule dynamics but also indicate that Jtat-induced apoptosis might contribute to Jembrana disease pathogenesis...
  4. Chadwick B, Coelen R, Wilcox G, Sammels L, Kertayadnya G. Nucleotide sequence analysis of Jembrana disease virus: a bovine lentivirus associated with an acute disease syndrome. J Gen Virol. 1995;76 ( Pt 7):1637-50 pubmed
    ..The significance of these changes is discussed in relation to the differences in pathogenicity between JDV and BIV...
  5. Wareing S, Hartaningsih N, Wilcox G, Penhale W. Evidence for immunosuppression associated with Jembrana disease virus infection of cattle. Vet Microbiol. 1999;68:179-85 pubmed
    ..abortus Strain 19 was delayed. The results indicate that the humoral immune response is suppressed and delayed in JDV infected cattle...
  6. Stewart M, Desport M, Setiyaningsih S, Hartaningsih N, Wilcox G. Analysis of Jembrana disease virus mRNA transcripts produced during acute infection demonstrates a complex transcription pattern. Virus Res. 2008;135:336-9 pubmed publisher
    ..A 67 nucleotide putative non-coding exon was identified that shared the same splice acceptor (SA) as vif and was incorporated into alternative transcripts of tat, rev and env...
  7. Chadwick B, Desport M, Brownlie J, Wilcox G, Dharma D. Detection of Jembrana disease virus in spleen, lymph nodes, bone marrow and other tissues by in situ hybridization of paraffin-embedded sections. J Gen Virol. 1998;79 ( Pt 1):101-6 pubmed
    ..The relatively high level of infection found in bone marrow suggested that its involvement may be important in the disease pathogenesis, as it is with other lentiviruses...
  8. McNab T, Desport M, Dobson R, Tenaya I, Hartaningsih N, Wilcox G. Prior bovine immunodeficiency virus infection does not inhibit subsequent superinfection by the acutely pathogenic Jembrana disease virus. Virology. 2010;404:261-8 pubmed publisher
    In cattle the interaction between the two genetically and antigenically related bovine lentiviruses, the acutely pathogenic Jembrana disease virus (JDV) and the non-pathogenic Bovine immunodeficiency virus (BIV) has not been reported ..
  9. Chadwick B, Coelen R, Sammels L, Kertayadnya G, Wilcox G. Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus. J Gen Virol. 1995;76 ( Pt 1):189-92 pubmed
    ..This confirmed that JDV is a lentivirus and that it is distinguishable from BIV. The pathogenesis of Jembrana disease is most unusual for a lentivirus infection and differs markedly from that reported for BIV infection...
  10. Desport M, Tenaya I, McLachlan A, McNab T, Rachmat J, Hartaningsih N, et al. In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection. Virology. 2009;393:221-7 pubmed publisher
    ..The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus...
  11. Desport M, Ditcham W, Lewis J, McNab T, Stewart M, Hartaningsih N, et al. Analysis of Jembrana disease virus replication dynamics in vivo reveals strain variation and atypical responses to infection. Virology. 2009;386:310-6 pubmed publisher
    ..Most of these cattle developed normal Tm-specific antibody responses between 4-12 weeks post-infection...
  12. Hartaningsih N, Dharma D, Soeharsono S, Wilcox G. The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens. Vet Immunol Immunopathol. 2001;78:163-76 pubmed
    ..The vaccination procedure suppressed the duration and severity of the disease but did not completely prevent the development of disease in animals challenged with 100 infectious doses of virus...
  13. Desport M, Stewart M, Mikosza A, Sheridan C, Peterson S, Chavand O, et al. Sequence analysis of Jembrana disease virus strains reveals a genetically stable lentivirus. Virus Res. 2007;126:233-44 pubmed
    ..JDV appears to be remarkably stable genetically and has undergone minor genetic changes over a period of nearly 20 years in Bali despite becoming endemic in the cattle population of the island...
  14. Deng G, Qiao W, Su Y, Sha R, Geng Y, Chen Q. Internalization of Jembrana disease virus Tat: possible pathway and implication. Virus Res. 2006;121:122-33 pubmed
    ..Based on our findings, we propose that secretion and internalization of JTat may be a way for JDV to influence neighbouring cells and make the cellular environment more amenable to viral infection...
  15. Metharom P, Takyar S, Xia H, Ellem K, Wilcox G, Wei M. Development of disabled, replication-defective gene transfer vectors from the Jembrana disease virus, a new infectious agent of cattle. Vet Microbiol. 2001;80:9-22 pubmed
    ..To our knowledge, this is the first such vector system developed from a cattle virus...
  16. Kempster S, Collins M, Brownlie J. Tat protein expression in MDBK cells does not confer susceptibility to bovine immunodeficiency virus. Arch Virol. 2002;147:643-9 pubmed
    ..Whether viral entry into MDBK cells is also a block to BIV R29 infection of MDBK cells has yet to be established...
  17. Curran M, Nolan G. Nonprimate lentiviral vectors. Curr Top Microbiol Immunol. 2002;261:75-105 pubmed
  18. Soeharsono S, Wilcox G, Dharma D, Hartaningsih N, Kertayadnya G, Budiantono A. Species differences in the reaction of cattle to Jembrana disease virus infection. J Comp Pathol. 1995;112:391-402 pubmed
    ..The inoculated crossbred cattle were viraemic for 3 months and developed an antibody response to the virus that persisted for at least 46 weeks after infection...
  19. Chen H, He J, Fong S, Wilcox G, Wood C. Jembrana disease virus Tat can regulate human immunodeficiency virus (HIV) long terminal repeat-directed gene expression and can substitute for HIV Tat in viral replication. J Virol. 2000;74:2703-13 pubmed
    ..Further characterization of this chimeric virus will help to elucidate how JDV Tat functions and to explain the differences between HIV and JDV Tat transactivation...
  20. Desport M, Stewart M, Sheridan C, Ditcham W, Setiyaningsih S, Tenaya W, et al. Recombinant Jembrana disease virus gag proteins identify several different antigenic domains but do not facilitate serological differentiation of JDV and nonpathogenic bovine lentiviruses. J Virol Methods. 2005;124:135-42 pubmed
    In Indonesia, it is suspected that there are two bovine lentiviruses circulating in the cattle population: a pathogenic Jembrana disease virus (JDV), and a nonpathogenic bovine immunodeficiency-like virus (BIV)...
  21. Snider T, Hoyt P, Coats K, Graves K, Cooper C, Storts R, et al. Natural bovine lentiviral type 1 infection in Holstein dairy cattle. I. Clinical, serological, and pathological observations. Comp Immunol Microbiol Infect Dis. 2003;26:89-101 pubmed
    ..The chronic disease syndrome in dairy cows associated with BIV may be useful as a model system for investigation of the pathogenesis of the nervous system lesions and lymphoid organ changes that occur in humans with lentiviral infection...
  22. Lu M, Zheng L, Mitchell K, Kapil S, Wood C, Minocha H. Unique epitope of bovine immunodeficiency virus gag protein spans the cleavage site between p16(MA) and p2L. Clin Diagn Lab Immunol. 2002;9:1277-81 pubmed
    Bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) are closely related bovine lentiviruses that are difficult to distinguish by presently available diagnostic methods...