radiation leukemia virus

Summary

Summary: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from radiation-induced lymphomas in C57BL mice. It is leukemogenic, thymotrophic, can be transmitted vertically, and replicates only in vivo.

Top Publications

  1. Lambert J, Bergeron D, Kozak C, Rassart E. Identification of a common site of provirus integration in radiation leukemia virus-induced T-cell lymphomas in mice. Virology. 1999;264:181-6 pubmed
    The BL/VL(3) Kaplan radiation leukemia virus (RadLV-VL(3)) is a nondefective retrovirus that induces T cell lymphomas in several strains of mice...
  2. Poliquin L, Bergeron D, Fortier J, Paquette Y, Bergeron R, Rassart E. Determinants of thymotropism in Kaplan radiation leukemia virus and nucleotide sequence of its envelope region. J Virol. 1992;66:5141-6 pubmed
    ..Thus, the LTR and envelope gene may be involved in complementary action to lead to thymotropism...
  3. Yefenof E, Abboud G, Epszteyn S, Vitetta E. Treatment of premalignancy: prevention of lymphoma in radiation leukemia virus-inoculated mice by cyclosporin A and immunotoxin. Proc Natl Acad Sci U S A. 1992;89:728-32 pubmed
    b>Radiation leukemia virus (RadLV)-induced preleukemic (PL) latency is characterized by the appearance of virus-infected PL cells in the thymus. The survival of these PL cells is dependent upon autostimulation with interleukin 4 (IL-4)...
  4. Landais S, Quantin R, Rassart E. Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene. J Virol. 2005;79:11443-56 pubmed
    ..With the recent release of the mouse genome sequence, high-throughput retroviral tagging emerges as a powerful tool in the quest for oncogenes. It also allows the analysis of large DNA regions surrounding the integration locus...
  5. O Neill H. Unique lymphoid cell subset target to infection and proliferation induced in vitro by a murine leukemia virus. Leukemia. 1992;6:272-81 pubmed
    ..Viruses such as the murine radiation leukemia virus (RadLV) induce oncogenic transformation of T-cells in the thymus only in vivo and after a long latency...
  6. Sen Majumdar A, Weissman I, Hansteen G, Marian J, Waller E, Lieberman M. Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T-cell receptor V beta gene products. J Virol. 1994;68:1165-72 pubmed
    ..place during the process of neoplastic transformation in the thymocytes of C57BL/Ka mice infected by the radiation leukemia virus (RadLV)...
  7. Yefenof E, Ela C, Kotler M, Vitetta E. Induction of IL-4 secretion by the radiation leukemia virus (RadLV): role in autocrine growth stimulation of RadLV infected pre-leukemic cells. Int J Cancer. 1992;50:481-5 pubmed
    ..The results suggest that RadLV induces IL-4-dependent autocrine growth which maintains a population of PL T cells in the thymus. Transition from a PL state to overt thymic lymphoma involves emancipation of a PL cell from IL-4 dependency...
  8. Ishiguro N, Brown G, Ishizu A, Meruelo D. The regulation of murine H-2Dd expression by activation transcription factor 1 and cAMP response element binding protein. J Immunol. 1998;160:5907-14 pubmed
    Resistance to radiation leukemia virus (RadLV)-induced leukemia is correlated with an increase in H-2Dd expression on the thymocyte surface...
  9. O Neill H. Radiation leukemia virus-induced T-cell lymphomas with common T-cell receptor variable region structure and similar binding specificity for retrovirus. Leukemia. 1991;5:921-7 pubmed
    The 5C2 cell line was derived following culture of mouse spleen cells exposed in vivo and in vitro to radiation leukemia virus (RadLV) containing supernatants from the C6VL/1 T cell lymphoma...

More Information

Publications34

  1. Rahmouni S, Aandahl E, Nayjib B, Zeddou M, Giannini S, Verlaet M, et al. Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice. Biochem J. 2004;384:469-76 pubmed
    ..Treatment with cyclo-oxygenase type 2 inhibitors reduces the level of PGE2 and thereby reverses the T-cell anergy, restores the T-cell immune function and ameliorates the lymphoproliferative disease...
  2. Ho E, O Neill T, O Neill H. Induction of leukemia in mice using a radiation leukemia virus-induced cell line: a model system for studying oncogenic progression. Leuk Res. 1995;19:83-93 pubmed
    ..developed using a cell line isolated following in vitro infection with the slowly transforming murine radiation leukemia virus (RadLV)...
  3. Avni O, Yefenof E, Kotler M. Clonal dominance of RadLV-induced lymphomas. Leuk Res. 1995;19:971-6 pubmed
    ..The speed at which a dominant lymphoma outgrew the co-culture suggested that dominance is acquired through the ability of the prevailing cells to actively suppress the growth of recessive cells...
  4. Onishi Y, Kizaki H. Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors. Biochem Biophys Res Commun. 1996;228:7-13 pubmed
    ..These results suggest that the early down-regulation of these genes contributes to the cytotoxicity of the topoisomerase inhibitors that induce DNA cleavage...
  5. O Neill H. A murine retrovirus induces proliferation of unique lymphoid cell lines expressing T-cell-receptor structures utilizing common variable region alpha and beta chain genes. Proc Natl Acad Sci U S A. 1993;90:2603-7 pubmed
    A murine radiation leukemia virus (RadLV) has been shown to induce in vitro proliferation of an unusual subset of lymphoid cells from spleen...
  6. Haran Ghera N, Peled A, Wu L, Shortman K, Brightman B, Fan H. The effects of passive antiviral immunotherapy in AKR mice: I. The susceptibility of AKR mice to spontaneous and induced T cell lymphomagenesis. Leukemia. 1995;9:1199-206 pubmed
    ..Intrathymic injection of the radiation leukemia virus variant A-RadLV or administration of methylnitrosourea resulted in a high lymphoma incidence within a ..
  7. Colombi S, Deprez M, de Leval L, Humblet C, Greimers R, Defresne M, et al. Thymus involvement in murine acquired immunodeficiency (MAIDS). Thymus. 1994;23:27-37 pubmed
    ..Finally, an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in the periphery also appeared in the thymus and its frequency was strongly correlated with the expansion of B-cells in this organ...
  8. Brown G, Nobunaga T, Morris D, Meruelo D. In vivo stimulation of H-2Dd expression following RadLV infection of thymocytes: increased transcription and DNA-binding activity to sequences 5' of the Dd gene. Res Immunol. 1991;142:431-40 pubmed
    ..abstract truncated at 400 words)..
  9. Landais S, Landry S, Legault P, Rassart E. Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia. Cancer Res. 2007;67:5699-707 pubmed
    ..the identification of the Kis2 common retrovirus integration site, located on mouse chromosome X, in radiation leukemia virus-induced T-cell leukemias...
  10. Yefenof E, Einat E, Klein E. Potentiation of T cell immunity against radiation-leukemia-virus-induced lymphoma by polysaccharide K. Cancer Immunol Immunother. 1991;34:133-7 pubmed
    C57BL mice inoculated with radiation leukemia virus (RadLV) develop preleukemic cells long before the onset of leukemia...
  11. Ho E, O Neill H. T-cell differentiative capacity of haematopoietic stem cells immortalized in vitro with radiation leukemia virus. Leukemia. 1993;7:1281-90 pubmed
    ..The cell lines described here represent valuable models for studying T-cell differentiation from lymphoid stem cells, and for dissecting the early events in leukemogenesis...
  12. Gorska Flipot I, Huang M, Cantin M, Rassart E, Masse G, Jolicoeur P. U3 long terminal repeat-mediated induction of intracellular immunity by a murine retrovirus: a novel model of latency for retroviruses. J Virol. 1992;66:7201-10 pubmed
    BL/VL3 radiation leukemia virus (RadLV) is a thymotropic, highly leukemogenic murine leukemia virus (MuLV) which is unable to replicate in vitro in mouse fibroblasts...
  13. Ishiguro N, Brown G, Meruelo D. Activation transcription factor 1 involvement in the regulation of murine H-2Dd expression. J Biol Chem. 1997;272:15993-6001 pubmed
    Resistance to radiation leukemia virus-induced leukemia is correlated with an increase in H-2D expression on the thymocyte surface...
  14. Epzsteyn S, Vitetta E, Yefenof E. Prophylactic intervention in RadLV-induced lymphomagenesis with an anti-IL-4 monoclonal antibody. J Immunother. 1997;20:287-91 pubmed
    Intrathymic inoculation of the radiation leukemia virus (RadLV) into C57BL/6 mice induces thymic lymphomas after 4-6 months...
  15. Martin Simonet M, Marini V, Ricciardi Castagnoli P, Astier Gin T, Greimers R, Boniver J, et al. A RadLV-induced gamma delta T cell lymphoma displaying an antitumoral cytotoxicity. Scand J Immunol. 1994;40:144-50 pubmed
  16. Conti A, Haran Ghera N, Maestroni G. Role of pineal melatonin and melatonin-induced-immuno-opioids in murine leukemogenesis. Med Oncol Tumor Pharmacother. 1992;9:87-92 pubmed
    ..005 and p < 0.01). Moreover, the action of melatonin was blocked by naltrexone (p < 0.005), indicating the involvement of melatonin-induced-immuno-opioids in the development of the lymphomas...
  17. Bashi O, Ehrlich R. Characterization of mature and immature RadLV-induced thymic T-cell lines for tumorigenesis and MHC-class-I gene expression. Int J Cancer. 1995;61:67-75 pubmed
  18. Ho E, Jolly C, O Neill H. Analysis of oncogenic progression in a radiation leukemia virus model. Leukemia. 1994;8:1202-13 pubmed
    ..Cell lines have been isolated following in vitro infection of lymphoid cells with radiation leukemia virus (RadLV) and they have been used to develop a two-step model for leukemia development...
  19. Yefenof E, Gafanovitch I, Oron E, Bar M, Klein E. Prophylactic intervention in radiation-leukemia-virus-induced murine lymphoma by the biological response modifier polysaccharide K. Cancer Immunol Immunother. 1995;41:389-96 pubmed
    ..Mice inoculated with the radiation leukemia virus (RadLV) develop thymic lymphomas after a latency of 3-6 months...
  20. O Neill H. Growth regulation of a T-cell lymphoma via the T-cell receptor. Leuk Res. 1994;18:23-8 pubmed
    ..All data suggest that these cells can receive growth stimulation via the T-cell receptor (TCR) and IL-2 receptor, implicating autocrine stimulation of growth involving IL-2 and retroviral gene products...
  21. Degar S, Lavie G, Meruelo D. Photodynamic inactivation of radiation leukemia virus produced from hypericin-treated cells. Virology. 1993;197:796-800 pubmed
    ..insight into the mechanism(s) by which hypericin exerts its antiretroviral effects, we have studied Radiation Leukemia virus (RadLV) produced from cells pulse-treated with hypericin...
  22. Nobunaga T, Brown G, Morris D, Meruelo D. A novel DNA binding activity is elevated in thymocytes expressing high levels of H-2Dd after radiation leukemia virus infection. J Immunol. 1992;149:871-9 pubmed
    Resistance to radiation leukemia virus-induced leukemia is mediated by gene(s) in the H-2D region of the MHC; a clear correlation exists between disease resistance and increased H-2Dd expression on the thymocyte surface...
  23. Khimani A, Lim M, Graf T, Smith T, Ruprecht R. Phylogenetic relationship of the complete Rauscher murine leukemia virus genome with other murine leukemia virus genomes. Virology. 1997;238:64-7 pubmed
    ..virus (Mo-MuLV) was the next closest relative to R-MuLV and F-MuLV on all trees, followed by Akv and radiation leukemia virus (RadLV). The most distantly related helper virus was Hortulanus murine leukemia virus (Ho-MuLV)...
  24. Tremblay P, Kozak C, Jolicoeur P. Identification of a novel gene, Vin-1, in murine leukemia virus-induced T-cell leukemias by provirus insertional mutagenesis. J Virol. 1992;66:1344-53 pubmed
    The BL/VL3 radiation leukemia virus is a nondefective retrovirus which induces clonal or oligoclonal T-cell leukemia in mice...
  25. Lonai P, Katz E, Haran Ghera N. I-region linked complementing loci in resistance to viral leukemogenesis in the mouse. Immunogenetics. 1980;10:535-43 pubmed
    A-RadLV, a variant of the radiation leukemia virus, inoculated intrathymically into adult mice, causes a high frequency of leukemia in haplotypes b, f, k, d, p and j on the B10 background, whereas H-2s mice are resistant...