moloney murine leukemia virus

Summary

Summary: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.

Top Publications

  1. Yang F, Seamon J, Roth M. Mutational analysis of the N-terminus of Moloney murine leukemia virus integrase. Virology. 2001;291:32-45 pubmed
    ..The Moloney murine leukemia virus (M-MuLV) IN encodes a unique 45-amino-acid domain N-terminal to the HHCC motif...
  2. Coté M, Pflomm M, Georgiadis M. Staying straight with A-tracts: a DNA analog of the HIV-1 polypurine tract. J Mol Biol. 2003;330:57-74 pubmed
    ..On the basis of our analysis, we suggest that the specific topology of long pure A-tracts is remarkably comparable across a wide array of biological environments. ..
  3. Nanmoku K, Kawano M, Iwasaki Y, Ikenaka K. Highly efficient gene transduction into the brain using high-titer retroviral vectors. Dev Neurosci. 2003;25:152-61 pubmed
    ..Moreover, we demonstrated that predominant gene delivery into the neurons of one cortical layer can be achieved by choosing an appropriate date of retroviral infection...
  4. Villanueva R, Jonsson C, Jones J, Georgiadis M, Roth M. Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions. Virology. 2003;316:146-60 pubmed
    ..For Moloney murine leukemia virus (M-MuLV) IN, the limited solubility of the recombinant protein has restricted the development of ..
  5. Das D, Georgiadis M. The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus. Structure. 2004;12:819-29 pubmed
    ..We now report the first crystal structure of the full-length Moloney murine leukemia virus (MMLV) RT at 3.0 A resolution...
  6. Flynn J, An W, King S, Telesnitsky A. Nonrandom dimerization of murine leukemia virus genomic RNAs. J Virol. 2004;78:12129-39 pubmed
    ..Here, virion RNA homo- and heterodimerization were examined for Moloney murine leukemia virus (MLV) using nondenaturing Northern blotting and a novel RNA dimer capture assay...
  7. Bullock A, Debreczeni J, Fedorov O, Nelson A, Marsden B, Knapp S. Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. J Med Chem. 2005;48:7604-14 pubmed
  8. Kubo Y, Ishimoto A, Amanuma H. Genistein, a protein tyrosine kinase inhibitor, suppresses the fusogenicity of Moloney murine leukemia virus envelope protein in XC cells. Arch Virol. 2003;148:1899-914 pubmed
    ..This result indicates that protein tyrosine kinase activity is associated with the high sensitivity of XC cells to ecotropic Env-induced syncytium formation. ..
  9. Ambrosi A, Cattoglio C, Di Serio C. Retroviral integration process in the human genome: is it really non-random? A new statistical approach. PLoS Comput Biol. 2008;4:e1000144 pubmed publisher
    ..The statistical goodness of fit test shows the suitability of this distribution to the observed data. Our statistical analysis confirms the preference of MLV-based vectors to integrate in promoter-proximal regions. ..

More Information

Publications86

  1. Wolf D, Goff S. TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell. 2007;131:46-57 pubmed
    b>Moloney murine leukemia virus (M-MLV) replication is restricted in embryonic carcinoma (EC) and embryonic stem (ES) cells, likely to protect the germ line from insertional mutagenesis...
  2. Toni N, Laplagne D, Zhao C, Lombardi G, Ribak C, Gage F, et al. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci. 2008;11:901-7 pubmed publisher
    ..Our structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter. ..
  3. Bai Y, Soda Y, Izawa K, Tanabe T, Kang X, Tojo A, et al. Effective transduction and stable transgene expression in human blood cells by a third-generation lentiviral vector. Gene Ther. 2003;10:1446-57 pubmed
    ..The transduction efficiency of the HIV-1-based vector was compared directly with the Moloney murine leukemia virus (MLV) SIN vector in human leukemia cell lines...
  4. Kines K, Mann V, Morales M, Shelby B, Kalinna B, Gobert G, et al. Transduction of Schistosoma mansoni by vesicular stomatitis virus glycoprotein-pseudotyped Moloney murine leukemia retrovirus. Exp Parasitol. 2006;112:209-20 pubmed
    ..Together these results indicated productive transduction by VSVG pseudotyped MMLV of cultured schistosomes, and suggest a tractable route forward towards heritable schistosome transgenesis. ..
  5. Bosticardo M, Ghosh A, Du Y, Jenkins N, Copeland N, Candotti F. Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells. Mol Ther. 2009;17:1910-8 pubmed publisher
  6. Hacein Bey Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, de Villartay J, et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med. 2002;346:1185-93 pubmed
    ..Ex vivo gene therapy with gamma(c) can safely correct the immune deficiency of patients with X-linked severe combined immunodeficiency. ..
  7. Gerard G, Potter R, Smith M, Rosenthal K, Dhariwal G, Lee J, et al. The role of template-primer in protection of reverse transcriptase from thermal inactivation. Nucleic Acids Res. 2002;30:3118-29 pubmed
    We compared the thermal stabilities of wild-type recombinant avian myeloblastosis virus (AMV) and Moloney murine leukemia virus (M-MLV) reverse transcriptase (RT) with those of mutants of the recombinant enzymes lacking RNase H activity...
  8. Yoshii H, Kamiyama H, Amanuma H, Oishi K, Yamamoto N, Kubo Y. Mechanisms underlying glycosylation-mediated loss of ecotropic receptor function in murine MDTF cells and implications for receptor evolution. J Gen Virol. 2008;89:297-305 pubmed
    A Mus dunni tail fibroblast (MDTF) cell line is highly resistant to infection by ecotropic Moloney murine leukemia virus (Mo-MLV)...
  9. Low A, Okeoma C, Lovsin N, de las Heras M, Taylor T, Peterlin B, et al. Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene. Virology. 2009;385:455-63 pubmed publisher
    ..These studies indicate that mA3 restricts replication and pathogenesis of M-MuLV in vivo. ..
  10. Orlova M, Yueh A, Leung J, Goff S. Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination. Cell. 2003;115:319-31 pubmed
    ..These results suggest that RT enhances suppression of termination and that the interaction of RT with eRF1 is required for an appropriate level of translational readthrough. ..
  11. Shi Q, Singh K, Srivastava A, Kaushik N, Modak M. Lysine 152 of MuLV reverse transcriptase is required for the integrity of the active site. Biochemistry. 2002;41:14831-42 pubmed
    ..These results further indicate that the catalytic mechanism of MuLV RT is significantly different from that of HIV-1 RT, despite the presence of a number of conserved motifs and amino acid residues. ..
  12. Jung Y, Wu T, Kozak C. Novel host range and cytopathic variant of ecotropic Friend murine leukemia virus. J Virol. 2004;78:12189-97 pubmed
    ..dunni and hamster cells have variant CAT-1 receptors, these results suggest that syncytium formation as well as altered host range may be a consequence of altered interaction between virus and receptor...
  13. Tahvanainen J, Kylaniemi M, Kanduri K, Gupta B, Lähteenmäki H, Kallonen T, et al. Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation. J Biol Chem. 2013;288:3048-58 pubmed publisher
    ..The serine/threonine-specific proviral integration site for Moloney murine leukemia virus (PIM) kinases PIM1 and PIM2 have been implicated in the cytokine-dependent proliferation and survival ..
  14. Kubo Y, Amanuma H. Mutational analysis of the R peptide cleavage site of Moloney murine leukaemia virus envelope protein. J Gen Virol. 2003;84:2253-7 pubmed
    ..This result strongly supports that R peptide cleavage is required for virus entry. ..
  15. Wang M, Kim W, Gao G, Torrey T, Morse H, De Camilli P, et al. Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production. J Biol. 2003;3:4 pubmed
    ..A search for novel partners interacting with the Gag protein of the Moloney murine leukemia virus (Mo-MuLV) via the yeast two-hybrid protein-protein interaction assay resulted in the identification of ..
  16. Chao S, Walker J, Chanda S, Gray N, Caldwell J. Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus. Mol Cell Biol. 2003;23:831-41 pubmed
    ..Here we find that three CDKIs, flavopiridol, purvalanol A, and methoxy-roscovitine, block Moloney murine leukemia virus (MLV) transcription events...
  17. Liu N, Kuang X, Kim H, Stoica G, Qiang W, Scofield V, et al. Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in MoMuLV-ts1-induced apoptosis in astrocytes. J Neurovirol. 2004;10:189-98 pubmed
    The Moloney murine leukemia virus (MoMuLV)-ts1 retrovirus, a naturally occurring mutant of MoMuLV-TB, causes a neuroimmunodegenerative syndrome in mice...
  18. Jadwin J, Rudd V, Sette P, Challa S, Bouamr F. Late domain-independent rescue of a release-deficient Moloney murine leukemia virus by the ubiquitin ligase itch. J Virol. 2010;84:704-15 pubmed publisher
    b>Moloney murine leukemia virus (MoMLV) Gag utilizes its late (L) domain motif PPPY to bind members of the Nedd4-like ubiquitin ligase family...
  19. Leung J, Yueh A, Appah F, Yuan B, De los Santos K, Goff S. Interaction of Moloney murine leukemia virus matrix protein with IQGAP. EMBO J. 2006;25:2155-66 pubmed
    The matrix protein (MA) of the Moloney murine leukemia virus (M-MuLV) was found to interact with IQGAP1, a prominent regulator of the cytoskeleton...
  20. D Souza V, Dey A, Habib D, Summers M. NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus. J Mol Biol. 2004;337:427-42 pubmed
    The full length, positive-strand genome of the Moloney Murine Leukemia Virus contains a "core encapsidation signal" that is essential for efficient genome packaging during virus assembly...
  21. Ly H, Parslow T. Bipartite signal for genomic RNA dimerization in Moloney murine leukemia virus. J Virol. 2002;76:3135-44 pubmed
    ..Previous studies with Moloney murine leukemia virus (Mo-MuLV) identified two alternative DIS loci that can each independently support RNA dimerization in ..
  22. Auerbach M, Brown K, Singh I. Mutational analysis of the N-terminal domain of Moloney murine leukemia virus capsid protein. J Virol. 2007;81:12337-47 pubmed
    ..To examine the role of this domain in Moloney murine leukemia virus (MoMLV) replication, we analyzed 18 insertional mutations in this region...
  23. Sjöberg M, Lindqvist B, Garoff H. Stabilization of TM trimer interactions during activation of moloney murine leukemia virus Env. J Virol. 2008;82:2358-66 pubmed
    ..have studied the oligomer composition and stability of an intermediate and the fully activated form of Moloney murine leukemia virus (Mo-MLV) Env. Activation of Mo-MLV Env is controlled by isomerization of its intersubunit disulfide...
  24. Qiang W, Cahill J, Liu J, Kuang X, Liu N, Scofield V, et al. Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes. J Virol. 2004;78:11926-38 pubmed
    The neuroimmunodegenerative syndrome that develops in mice infected with ts1, a mutant of Moloney murine leukemia virus, resembles human AIDS...
  25. Perron M, Stremlau M, Song B, Ulm W, Mulligan R, Sodroski J. TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells. Proc Natl Acad Sci U S A. 2004;101:11827-32 pubmed
    ..Our results demonstrate that species-specific variation in TRIM5alpha governs its ability to block infection by diverse retroviruses...
  26. Gherghe C, Leonard C, Gorelick R, Weeks K. Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain. J Virol. 2010;84:898-906 pubmed publisher
    ..These experiments support well-defined structural models for an authentic dimerization domain and also emphasize that many features of mature genomic RNA dimers can be reproduced in vitro using properly designed, simplified RNAs...
  27. Miyazaki Y, Garcia E, King S, Iyalla K, Loeliger K, Starck P, et al. An RNA structural switch regulates diploid genome packaging by Moloney murine leukemia virus. J Mol Biol. 2010;396:141-52 pubmed publisher
    ..Recent studies with small fragments of the Moloney murine leukemia virus (MoMuLV) genome suggested that selection may be mediated by an RNA switch mechanism, in which ..
  28. Acevedo M, Arbildúa J, Monasterio O, Toledo H, Leon O. Role of the 207-218 peptide region of Moloney murine leukemia virus integrase in enzyme catalysis. Arch Biochem Biophys. 2010;495:28-34 pubmed publisher
    ..We propose that the peptide region 207-216 is a flexible loop and that H208, Y211, R212 and Q214 of this loop are involved in the correct assembly of the DNA-integrase complex during integration...
  29. Ketteler R, Glaser S, Sandra O, Martens U, Klingmuller U. Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors. Gene Ther. 2002;9:477-87 pubmed
    ..To overcome these problems we modified the widely used Moloney murine leukemia virus-derived retroviral vector pMX by replacing the 3'LTR with the spleen focus-forming virus LTR and ..
  30. Prasad Alur R, Foley B, Parente M, Tobin D, Heuer G, Avadhani A, et al. Modification of multiple transcriptional regulatory elements in a Moloney murine leukemia virus gene transfer vector circumvents silencing in fibroblast grafts and increases levels of expression of the transferred enzyme. Gene Ther. 2002;9:1146-54 pubmed
    ..This resulted in more than a 50-fold increase in total activity compared with the previous highest expressing vector...
  31. Lund A, Turner G, Trubetskoy A, Verhoeven E, Wientjens E, Hulsman D, et al. Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nat Genet. 2002;32:160-5 pubmed
    ..We infected Cdkn2a(-/-) mice with Moloney murine leukemia virus (MoMuLV) to screen for loci that can participate in tumorigenesis in collaboration with loss of the ..
  32. Yueh A, Goff S. Phosphorylated serine residues and an arginine-rich domain of the moloney murine leukemia virus p12 protein are required for early events of viral infection. J Virol. 2003;77:1820-9 pubmed
    Mutational analyses of the p12 Gag phosphoprotein of Moloney murine leukemia virus have demonstrated its participation in both virus assembly and the early stages of infection...
  33. Katane M, Fujita R, Takao E, Kubo Y, Aoki Y, Amanuma H. An essential role for the His-8 residue of the SDF-1alpha-chimeric, tropism-redirected Env protein of the Moloney murine leukemia virus in regulating postbinding fusion events. J Gene Med. 2004;6:260-7 pubmed
    ..Previously, we reported that a Moloney murine leukemia virus (MLV) retroviral vector containing a human stromal-derived factor-1alpha (SDF-1alpha)-chimeric ..
  34. da Silveira G, Oliveira Costa J, Soave D, Zanetti J, Soares F, Ribeiro Silva A. Relationship between B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) and homologous recombination regulatory genes in invasive ductal breast carcinomas. Histol Histopathol. 2012;27:1353-9 pubmed publisher
    B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is a Polycomb group protein that is able to induce telomerase activity, enabling the immortalization of epithelial cells...
  35. Cattoglio C, Pellin D, Rizzi E, Maruggi G, Corti G, Miselli F, et al. High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors. Blood. 2010;116:5507-17 pubmed publisher
    ..sequencing technology to build genomewide, high-definition maps of > 60 000 integration sites of Moloney murine leukemia virus (MLV)- and HIV-based retroviral vectors in the genome of human CD34(+) multipotent hematopoietic ..
  36. Li T, Zhang J. Intramolecular recombinations of Moloney murine leukemia virus occur during minus-strand DNA synthesis. J Virol. 2002;76:9614-23 pubmed
    ..of replication, 50 to 60% of retroviral recombinations occur between two identical sequences within a Moloney murine leukemia virus-based vector...
  37. Löving R, Li K, Wallin M, Sjöberg M, Garoff H. R-Peptide cleavage potentiates fusion-controlling isomerization of the intersubunit disulfide in Moloney murine leukemia virus Env. J Virol. 2008;82:2594-7 pubmed
    Fusion of the membrane of the Moloney murine leukemia virus (Mo-MLV) Env protein is facilitated by cleavage of the R peptide from the cytoplasmic tail of its TM subunit, but the mechanism for this effect has remained obscure...
  38. Suzuki Y, Craigie R. Regulatory mechanisms by which barrier-to-autointegration factor blocks autointegration and stimulates intermolecular integration of Moloney murine leukemia virus preintegration complexes. J Virol. 2002;76:12376-80 pubmed
    ..We have demonstrated that barrier-to-autointegration factor (BAF) blocks the autointegration of Moloney murine leukemia virus (MoMLV) PICs in vitro. In this study, we show that BAF is an authentic component of MoMLV...
  39. Kubo Y, Tominaga C, Yoshii H, Kamiyama H, Mitani C, Amanuma H, et al. Characterization of R peptide of murine leukemia virus envelope glycoproteins in syncytium formation and entry. Arch Virol. 2007;152:2169-82 pubmed
    ..These results provide valuable information for construction of efficient MLV vectors and for understanding the retroviral entry mechanism...
  40. Arezi B, Hogrefe H. Escherichia coli DNA polymerase III epsilon subunit increases Moloney murine leukemia virus reverse transcriptase fidelity and accuracy of RT-PCR procedures. Anal Biochem. 2007;360:84-91 pubmed
    In an effort to improve reverse transcriptase (RT) fidelity, we measured the error rate of Moloney murine leukemia virus (MMLV) RT in the presence of several autonomous and DNA polymerase-associated 3'-5' exonucleases using a lacZ ..
  41. Wolff L, Koller R, Hu X, Anver M. A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms. J Virol. 2003;77:4965-71 pubmed
    ..This agent is a Moloney murine leukemia virus (Mo-MuLV)-based virus that has most of the U3 region of the long terminal repeat (LTR) replaced with ..
  42. Onafuwa Nuga A, King S, Telesnitsky A. Nonrandom packaging of host RNAs in moloney murine leukemia virus. J Virol. 2005;79:13528-37 pubmed
    b>Moloney murine leukemia virus (MLV) particles contain both viral genomic RNA and an assortment of host cell RNAs...
  43. McGee Estrada K, Palmarini M, Hallwirth C, Fan H. A Moloney murine leukemia virus driven by the Jaagsiekte sheep retrovirus enhancers shows enhanced specificity for infectivity in lung epithelial cells. Virus Genes. 2005;31:257-63 pubmed
    ..the tissue specificity, we inserted the JSRV enhancer sequences from the U3 region of the LTR into a Moloney murine leukemia virus (M-MuLV) LTR lacking its own enhancer sequences, to give the chimeric LTR DeltaMo + JS...
  44. Johnson C, Lobelle Rich P, Puetter A, Levy L. Substitution of feline leukemia virus long terminal repeat sequences into murine leukemia virus alters the pattern of insertional activation and identifies new common insertion sites. J Virol. 2005;79:57-66 pubmed
    The recombinant retrovirus, MoFe2-MuLV (MoFe2), was constructed by replacing the U3 region of Moloney murine leukemia virus (M-MuLV) with homologous sequences from the FeLV-945 LTR...
  45. Suzuki Y, Yang H, Craigie R. LAP2alpha and BAF collaborate to organize the Moloney murine leukemia virus preintegration complex. EMBO J. 2004;23:4670-8 pubmed
    ..Depletion of LAP2alpha significantly inhibited viral replication. Our results demonstrate a critical contribution of LAP2alpha to the nucleoprotein organization of the PIC and to viral replication...
  46. Jung Y, Kozak C. Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus. J Virol. 2003;77:5065-72 pubmed
    ..dunni...
  47. Hibbert C, Rein A. Preliminary physical mapping of RNA-RNA linkages in the genomic RNA of Moloney murine leukemia virus. J Virol. 2005;79:8142-8 pubmed
    ..In an effort to localize these linkages, we digested deproteinized RNA from Moloney murine leukemia virus (MLV) particles with RNase H in the presence of oligodeoxynucleotides complementary to specific sites ..
  48. Ramirez J, Houzet L, Koller R, Bies J, Wolff L, Mougel M. Activation of c-myb by 5' retrovirus promoter insertion in myeloid neoplasms is dependent upon an intact alternative splice donor site (SD') in gag. Virology. 2004;330:398-407 pubmed
    ..Importantly, there was a complete lack of myeloid tumors associated with 5' insertional mutagenic activation of c-myb, suggesting the specific requirement of the SD' site in this mechanism...
  49. Schultz S, Zhang M, Champoux J. Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus. J Virol. 2003;77:5275-85 pubmed
    ..For Moloney murine leukemia virus, primer removal at the RNA/DNA junction leaves the 3' terminus of the plus-strand primer abutting the ..
  50. Curry J, McHale C, Smith M. Low efficiency of the Moloney murine leukemia virus reverse transcriptase during reverse transcription of rare t(8;21) fusion gene transcripts. Biotechniques. 2002;32:768, 770, 772, 754-5 pubmed
    ..The efficiency is shown to be directly proportional to RNA template levels. The Moloney murine leukemia virus (MMLV) reverse transcriptase enzyme's conversion efficiency was calculated to be approximately 20%...
  51. Duggan J, Okonta H, Chakraborty J. Transmission of Moloney murine leukemia virus (ts-1) by breast milk. J Gen Virol. 2006;87:2679-84 pubmed
    A murine model has been developed to study maternal transmission of the temperature-sensitive Moloney murine leukemia virus (ts-1)...
  52. Arezi B, McCarthy M, Hogrefe H. Mutant of Moloney murine leukemia virus reverse transcriptase exhibits higher resistance to common RT-qPCR inhibitors. Anal Biochem. 2010;400:301-3 pubmed publisher
    Inhibitor resistance of several commercial Moloney murine leukemia virus reverse transcriptase (MMLV RT) enzymes was investigated...
  53. Suzuki Y, Ogawa K, Koyanagi Y, Suzuki Y. Functional disruption of the moloney murine leukemia virus preintegration complex by vaccinia-related kinases. J Biol Chem. 2010;285:24032-43 pubmed publisher
    ..Barrier-to-autointegration factor (BAF), a cellular component of Moloney murine leukemia virus (MMLV) PICs, has been demonstrated to protect viral DNA from autointegration and stimulate the ..
  54. Kuang X, Hu W, Yan M, Wong P. Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice. Neurochem Int. 2010;57:738-48 pubmed publisher
    ..previously reported that accumulation of the precursor envelope protein gPr80(env) of ts1, a mutant of Moloney murine leukemia virus (MoMuLV), in the endoplasmic reticulum (ER) of infected astrocytes, results in ER stress, oxidative ..
  55. Nitta T, Lee S, Ha D, Arias M, Kozak C, Fan H. Moloney murine leukemia virus glyco-gag facilitates xenotropic murine leukemia virus-related virus replication through human APOBEC3-independent mechanisms. Retrovirology. 2012;9:58 pubmed publisher
    ..We examined XMRV to determine if its leader sequence contains glyco-gag activity, whether the presence of conventional gPr80Gag affects replication of XMRV, and we describe the evolution of glyco-gag-deficient MuLVs in Mus...
  56. Flynn J, Telesnitsky A. Two distinct Moloney murine leukemia virus RNAs produced from a single locus dimerize at random. Virology. 2006;344:391-400 pubmed
    ..For Moloney murine leukemia virus (MLV), co-packaged RNAs are not randomly selected from among all packaging-competent RNAs, but instead ..
  57. Ayuk F, Zander A, Fehse B. T lymphocytes as targets of gene transfer with Moloney-type retroviral vectors. Curr Gene Ther. 2001;1:325-37 pubmed
    ..More attention is thus being focused on the ability of gene-modified cells to carry out innate as well as conferred functions in vivo and the influence of culture conditions, retroviral vector and host response thereon...
  58. Studamire B, Goff S. Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors. Retrovirology. 2008;5:48 pubmed publisher
    ..Significant questions remain regarding the influence of host proteins on the selection of target sites, on the repair of integration intermediates, and on the efficiency of integration...
  59. Goodwin K, Long E, Georgiadis M. A host-guest approach for determining drug-DNA interactions: an example using netropsin. Nucleic Acids Res. 2005;33:4106-16 pubmed
    ..novel host-guest approach to study drug-DNA interactions in which the host, the N-terminal fragment of Moloney murine leukemia virus reverse transcriptase (MMLV RT) is co-crystallized with a DNA oligonucleotide guest in the presence ..
  60. Wallin M, Löving R, Ekström M, Li K, Garoff H. Kinetic analyses of the surface-transmembrane disulfide bond isomerization-controlled fusion activation pathway in Moloney murine leukemia virus. J Virol. 2005;79:13856-64 pubmed
    The surface (SU) and transmembrane (TM) subunits of Moloney murine leukemia virus (Mo-MLV) Env are disulfide linked. The linking cysteine in SU is part of a conserved CXXC motif in which the other cysteine carries a free thiol...
  61. Yueh A, Leung J, Bhattacharyya S, Perrone L, De los Santos K, Pu S, et al. Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection. J Virol. 2006;80:342-52 pubmed
    ..modifier (SUMO)-conjugating enzymes, as proteins interacting with the capsid (CA) protein of the Moloney murine leukemia virus. The binding site in CA for Ubc9 was mapped by deletion and alanine-scanning mutagenesis to a ..
  62. Vera J, Parissi V, Garcia A, Zuniga R, Andreola M, Caumont Sarcos A, et al. Yeast system as a model to study Moloney murine leukemia virus integrase: expression, mutagenesis and search for eukaryotic partners. J Gen Virol. 2005;86:2481-8 pubmed
    b>Moloney murine leukemia virus (M-MuLV) integrase (IN) catalyses the insertion of the viral genome into the host chromosomal DNA...
  63. Yasukawa K, Nemoto D, Inouye K. Comparison of the thermal stabilities of reverse transcriptases from avian myeloblastosis virus and Moloney murine leukaemia virus. J Biochem. 2008;143:261-8 pubmed
    ..Thermodynamic analysis indicates that thermal inactivation of AMV RT and MMLV RT is due to the large entropy change of activation for thermal inactivation...
  64. Yuan B, Fassati A, Yueh A, Goff S. Characterization of Moloney murine leukemia virus p12 mutants blocked during early events of infection. J Virol. 2002;76:10801-10 pubmed
    Mutations affecting either the N- or C-terminal regions of the Gag protein p12 block replication of Moloney murine leukemia virus (M-MuLV)...
  65. Onafuwa A, An W, Robson N, Telesnitsky A. Human immunodeficiency virus type 1 genetic recombination is more frequent than that of Moloney murine leukemia virus despite similar template switching rates. J Virol. 2003;77:4577-87 pubmed
  66. Inayoshi Y, Okino Y, Miyake K, Mizutani A, Yamamoto Kishikawa J, Kinoshita Y, et al. Transcription factor YY1 interacts with retroviral integrases and facilitates integration of moloney murine leukemia virus cDNA into the host chromosomes. J Virol. 2010;84:8250-61 pubmed publisher
    ..This study demonstrates that transcription factor Yin Yang 1 binds to Moloney murine leukemia virus, human immunodeficiency virus type 1, and avian sarcoma virus integrases...
  67. Auerbach M, Shu C, Kaplan A, Singh I. Functional characterization of a portion of the Moloney murine leukemia virus gag gene by genetic footprinting. Proc Natl Acad Sci U S A. 2003;100:11678-83 pubmed
    ..perform a near-saturation mutagenesis and functional analysis of 639 nucleotides in the gag region of Moloney murine leukemia virus. We report here the resulting functional map defined by eight footprints representing regions of ..
  68. Mikkers H, Berns A. Retroviral insertional mutagenesis: tagging cancer pathways. Adv Cancer Res. 2003;88:53-99 pubmed
    Slow transforming retroviruses, such as the Moloney murine leukemia virus (M-MuLV), induce tumors upon infection of a host after a relatively long latency period...
  69. Coté M, Roth M. Murine leukemia virus reverse transcriptase: structural comparison with HIV-1 reverse transcriptase. Virus Res. 2008;134:186-202 pubmed publisher
    Recent X-ray crystal structure determinations of Moloney murine leukemia virus reverse transcriptase (MoMLV RT) have allowed for more accurate structure/function comparisons to HIV-1 RT than were formerly possible...
  70. Aguilar H, Anderson W, Cannon P. Cytoplasmic tail of Moloney murine leukemia virus envelope protein influences the conformation of the extracellular domain: implications for mechanism of action of the R Peptide. J Virol. 2003;77:1281-91 pubmed
    The envelope (Env) protein of Moloney murine leukemia virus (MoMuLV) is a homotrimeric complex whose monomers consist of linked surface (SU) and transmembrane (TM) proteins cleaved from a precursor protein by a cellular protease...
  71. Seamon J, Jones K, Miller C, Roth M. Inserting a nuclear targeting signal into a replication-competent Moloney murine leukemia virus affects viral export and is not sufficient for cell cycle-independent infection. J Virol. 2002;76:8475-84 pubmed
    The effects of inserting reported nuclear localization signals (NLSs) into the Moloney murine leukemia virus (Mo-MuLV) integrase (IN) protein, within a replication-competent viral construct, were studied...
  72. Li K, Zhang S, Kronqvist M, Ekström M, Wallin M, Garoff H. The conserved His8 of the Moloney murine leukemia virus Env SU subunit directs the activity of the SU-TM disulphide bond isomerase. Virology. 2007;361:149-60 pubmed
    ..We found that wtEnv isomerized optimally at slightly basic pH whereas the partially active mutant required higher and the inactive mutants still higher pH. This suggests that His8 directs the ionization of the CXXC thiol...
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    We previously reported that Moloney murine leukemia virus-ts1-mediated neuronal degeneration in mice is likely a result of both loss of glial support and release of cytokines and neurotoxins from ts1-infected glial cells...
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    ..The retrovirus ts1, a mutant of Moloney murine leukemia virus, causes oxidative stress and progressive neuro- and immunopathology in mice infected soon after birth...
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    ..Thus, we have identified and characterized transcriptional repression of p27 by Id3 as a new mechanism decreasing p27 protein in tumors...
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    ..We investigated the effects of mouse APOBEC3 (mA3) and human APOBEC3G (hA3G) upon Moloney murine leukemia virus (MLV). We find that mA3 inactivates MLV but is significantly less effective against MLV than is hA3G...
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    ..We recently discovered that the NC protein of the Moloney murine leukemia virus (MLV) can bind with high affinity to conserved UCUG elements within the MLV packaging signal [D'Souza, ..