friend murine leukemia virus

Summary

Summary: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.

Top Publications

  1. Best S, Le Tissier P, Towers G, Stoye J. Positional cloning of the mouse retrovirus restriction gene Fv1. Nature. 1996;382:826-9 pubmed
  2. Tanaka K, Watanabe K, Yamaguchi S, Hasegawa M, Kitagawa M, Aizawa S. Cytological basis for enhancement of radiation-induced mortality by Friend leukaemia virus infection. Int J Radiat Biol. 2004;80:673-81 pubmed
    ..To analyse the cytological basis for enhancement of radiation-induced mortality by Friend leukaemia virus infection...
  3. Takase Yoden S, Watanabe R. A 0.3-kb fragment containing the R-U5-5' leader sequence is essential for the induction of spongiform neurodegeneration by A8 murine leukemia virus. Virology. 2005;336:1-10 pubmed
    b>Friend murine leukemia virus (Fr-MLV) clone A8 causes spongiform neurodegeneration in the rat brain. The A8-env gene is a primary determinant of neuropathogenicity, and the 1...
  4. Hasegawa M, Yamaguchi S, Aizawa S, Ikeda H, Tatsumi K, Noda Y, et al. Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site. Leuk Res. 2005;29:933-42 pubmed
    ..These findings indicated that DNA-PK would be essential for controlling the in vivo integration of FLV at specific sites as well as the susceptibility to FLV-induced leukemogenesis...
  5. Robertson S, Messer R, Carmody A, Hasenkrug K. In vitro suppression of CD8+ T cell function by Friend virus-induced regulatory T cells. J Immunol. 2006;176:3342-9 pubmed
    ..Such activity may also have adverse consequences by allowing viruses to establish and maintain chronic infections if suppression of antiviral immune responses occurs before virus eradication...
  6. Yamaguchi S, Hasegawa M, Suzuki T, Ikeda H, Aizawa S, Hirokawa K, et al. In vivo distribution of receptor for ecotropic murine leukemia virus and binding of envelope protein of Friend Murine leukemia virus. Arch Virol. 2003;148:1175-84 pubmed
  7. Bayer W, Schimmer S, Hoffmann D, Dittmer U, Wildner O. Evaluation of the Friend Virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies. Vaccine. 2008;26:716-26 pubmed
    ..Our results suggest that the FV model can provide insight into the development of improved adenovirus vectors for HIV-1 vaccination. ..
  8. He J, Cheng H, Wang Y, Zhu Y, Li G. Development of a real-time quantitative reverse transcriptase PCR assay for detection of the Friend leukemia virus load in murine plasma. J Virol Methods. 2008;147:345-50 pubmed
    ..The qRT-PCR assay described here allows specific, sensitive and direct detection of FLV and may also provide more precise measurement of FLV load. ..
  9. Ploquin M, Eksmond U, Kassiotis G. B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol. 2011;187:3321-30 pubmed publisher
    ..Our results suggest that B cell presentation of vaccine Ags could be manipulated to direct the appropriate CD4(+) T cell response...

More Information

Publications70

  1. Linder M, Wenzel V, Linder D, Stirm S. Structural elements in glycoprotein 70 from polytropic Friend mink cell focus-inducing virus and glycoprotein 71 from ecotropic Friend murine leukemia virus, as defined by disulfide-bonding pattern and limited proteolysis. J Virol. 1994;68:5133-41 pubmed
    ..and compared with that of glycoprotein 71 (gp71), the corresponding glycoprotein of the ecotropic Friend murine leukemia virus, which had previously been determined (M. Linder, D. Linder, J. Hahnen, H.-H. Schott, and Stirm, Eur. J...
  2. Iwanami N, Niwa A, Yasutomi Y, Tabata N, Miyazawa M. Role of natural killer cells in resistance against friend retrovirus-induced leukemia. J Virol. 2001;75:3152-63 pubmed
  3. Buller R, Sitbon M, Portis J. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. J Exp Med. 1988;167:1535-46 pubmed
    ..studies designed to examine the possible association of this endogenous gp70 with resistance of mice to Friend murine leukemia virus (F-MuLV)-induced erythroleukemia...
  4. Dittmer U, He H, Messer R, Schimmer S, Olbrich A, Ohlen C, et al. Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity. 2004;20:293-303 pubmed
    ..The results indicate that CD4(+) regulatory T cells contribute to viral persistence and demonstrate an immunotherapy for treating chronic retroviral infections. ..
  5. Bayer W, Tenbusch M, Lietz R, Johrden L, Schimmer S, Uberla K, et al. Vaccination with an adenoviral vector that encodes and displays a retroviral antigen induces improved neutralizing antibody and CD4+ T-cell responses and confers enhanced protection. J Virol. 2010;84:1967-76 pubmed publisher
    ..For presentation of the envelope protein gp70 of Friend murine leukemia virus on the adenoviral capsid, gp70 was fused to the adenovirus capsid protein IX...
  6. Pike R, Filby A, Ploquin M, Eksmond U, Marques R, Antunes I, et al. Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection. J Virol. 2009;83:11211-22 pubmed publisher
    ..Thus, these results suggest that FV-specific CD4(+) T cells provide significant direct protection against acute FV infection, the extent of which critically depends on the ratio of FV-infected cells to FV-specific CD4(+) T cells...
  7. Gerlach N, Gibbert K, Alter C, Nair S, Zelinskyy G, James C, et al. Anti-retroviral effects of type I IFN subtypes in vivo. Eur J Immunol. 2009;39:136-46 pubmed publisher
    ..The results demonstrate the distinct anti-retroviral effects of different IFN-alpha subtypes, which may be relevant for new therapeutic approaches...
  8. Ben David Y, Giddens E, Letwin K, Bernstein A. Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Genes Dev. 1991;5:908-18 pubmed
    The retroviral integration site Fli-1 is rearranged in 75% of the erythroleukemia cell clones induced by Friend murine leukemia virus (F-MuLV), whereas Spi-1/PU...
  9. Dittmer U, Brooks D, Hasenkrug K. Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms. J Virol. 1998;72:6554-8 pubmed
    ..The results indicated that immune mechanisms rather than viral interference mediated protection...
  10. Santiago M, Montano M, Benitez R, Messer R, Yonemoto W, Chesebro B, et al. Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science. 2008;321:1343-6 pubmed publisher
    ..The link between Apobec3 and neutralizing antibody responses highlights an Apobec3-dependent mechanism of host protection that might extend to HIV and other human retroviral infections...
  11. Nishigaki K, Hanson C, Thompson D, Yugawa T, Hisasue M, Tsujimoto H, et al. Analysis of the disease potential of a recombinant retrovirus containing Friend murine leukemia virus sequences and a unique long terminal repeat from feline leukemia virus. J Virol. 2002;76:1527-32 pubmed
    ..of this unique FeLV LTR, we replaced the U3 region of the LTR of the erythroleukemia-inducing Friend murine leukemia virus (F-MuLV) with that of FeLV clone 33...
  12. Santiago M, Smith D, Barrett B, Montano M, Benitez R, Pelanda R, et al. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011;85:189-99 pubmed publisher
    ..Overall, these findings argue against the generality of BAFF-R polymorphisms as a dominant mechanism to explain the Rfv3 recovery phenotype and further strengthen the evidence that Apobec3 encodes Rfv3...
  13. Sola B, Fichelson S, Bordereaux D, Tambourin P, Gisselbrecht S. fim-1 and fim-2: two new integration regions of Friend murine leukemia virus in myeloblastic leukemias. J Virol. 1986;60:718-25 pubmed
    ..Rearrangements of these two regions were found in F-MuLV-induced myeloblastic leukemias but not in 20 lymphoid or erythroid leukemias induced by the same virus...
  14. Hasegawa M, Kurata M, Yamamoto K, Yoshida K, Aizawa S, Kitagawa M. A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70. Leuk Res. 2009;33:1100-7 pubmed publisher
    ..Here, we show that the transduction of the env-gene (gp70) of Friend murine leukemia virus (F-MuLV) sensitized C3H-derived myeloid leukemia cells to DNA-damage (ionizing radiation as well as ..
  15. Takeda E, Tsuji Kawahara S, Sakamoto M, Langlois M, Neuberger M, Rada C, et al. Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo. J Virol. 2008;82:10998-1008 pubmed publisher
    ..These results indicate, for the first time, that mouse APOBEC3 is a physiologically functioning restriction factor to mouse gammaretroviruses...
  16. Yamamoto N, Takase Yoden S. Friend murine leukemia virus A8 regulates Env protein expression through an intron sequence. Virology. 2009;385:115-25 pubmed publisher
    b>Friend murine leukemia virus (Fr-MLV) produces unspliced mRNAs, as well as singly-spliced mRNAs by which the Env protein is generated...
  17. Iwashiro M, Messer R, Peterson K, Stromnes I, Sugie T, Hasenkrug K. Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc Natl Acad Sci U S A. 2001;98:9226-30 pubmed
    ..These results suggest a possible explanation for HIV- and human T cell leukemia virus-I-induced immunosuppression in the absence of T cell depletion...
  18. Zelinskyy G, Kraft A, Schimmer S, Arndt T, Dittmer U. Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection. Eur J Immunol. 2006;36:2658-70 pubmed
    ..Transfer as well as depletion experiments indicated that regulatory CD4+ cells developed during the second week of FV infection and subsequently suppressed CD8+ T cell functions, which was associated with impaired virus clearance...
  19. Takase Yoden S, Wada M, Watanabe R. A viral non-coding region determining neuropathogenicity of murine leukemia virus A8 is responsible for envelope protein expression in the rat brain. Microbiol Immunol. 2006;50:197-201 pubmed
    b>Friend murine leukemia virus clone A8 causes spongiform neurodegeneration in the rat brain. A 0.3-kb fragment containing the R-U5-5' leader sequence of A8 is required in addition to the A8-env gene to induce spongiosis...
  20. Messer R, Dittmer U, Peterson K, Hasenkrug K. Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection. Proc Natl Acad Sci U S A. 2004;101:12260-5 pubmed
    ..These results emphasize the importance of inducing both T cell responses and virus-neutralizing antibody responses for effective retroviral vaccine protection...
  21. Gerlach N, Schimmer S, Weiss S, Kalinke U, Dittmer U. Effects of type I interferons on Friend retrovirus infection. J Virol. 2006;80:3438-44 pubmed
    ..These findings indicate that type I IFN plays an important role in the immediate antiviral defense against Friend retrovirus infection...
  22. Stromnes I, Dittmer U, Schumacher T, Schepers K, Messer R, Evans L, et al. Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice. J Virol. 2002;76:2225-32 pubmed
    ..Eventually, all of the IFN-gamma-deficient mice failed to keep persistent virus in check and developed fatal FV-induced erythroleukemia...
  23. Bila C, Oberhauser V, Ammann C, Ejaz A, Huber G, Schimmer S, et al. Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell response. J Virol. 2011;85:1151-5 pubmed publisher
    ..Furthermore, we demonstrate that complement opsonization of Friend murine leukemia virus (F-MuLV) enhances infection of B cells, which correlates with increased potency of B cells to activate ..
  24. Gibbert K, Joedicke J, Meryk A, Trilling M, Francois S, Duppach J, et al. Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection. PLoS Pathog. 2012;8:e1002868 pubmed publisher
    ..The type I IFN subtypes 2 and 5, which bind the same receptor as IFN-?11, did not elicit similar antiviral effects. These results demonstrate a unique and subtype-specific activation of NK cells by IFN-?11...
  25. Balkow S, Krux F, Loser K, Becker J, Grabbe S, Dittmer U. Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells. Blood. 2007;110:3949-58 pubmed
    ..Thus, retroviral infection of DCs leads to an expansion of regulatory T cells, which might serve as an immune escape mechanism of the virus...
  26. Antunes I, Tolaini M, Kissenpfennig A, Iwashiro M, Kuribayashi K, Malissen B, et al. Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. Immunity. 2008;29:782-94 pubmed publisher
    ..Thus, sufficient numbers of polyclonal Treg cells may provide substantial protection against bone marrow pathology in chronic viral infections...
  27. Ogawa T, Tsuji Kawahara S, Yuasa T, Kinoshita S, Chikaishi T, Takamura S, et al. Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo. J Virol. 2011;85:5423-35 pubmed publisher
    ..Enhanced retroviral replication due to host gene-targeting resulted in markedly increased RAE-1 expression in the absence of massive erythroid cell proliferation, indicating a direct role of retroviral replication in RAE-1 upregulation...
  28. Zelinskyy G, Robertson S, Schimmer S, Messer R, Hasenkrug K, Dittmer U. CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection. J Virol. 2005;79:10619-26 pubmed
    ..These results demonstrate a broad impairment of cytotoxic CD8+ T-cell effector function during chronic retroviral infection and explain the inability of virus-specific CD8+ T cells to eliminate persistent virus...
  29. Robertson S, Messer R, Carmody A, Mittler R, Burlak C, Hasenkrug K. CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells. J Immunol. 2008;180:5267-74 pubmed
    ..However, the results demonstrate a potent strategy to potentiate the function of CD8(+) T cells in the context of immunosuppressive Treg cells. ..
  30. Robertson S, Ammann C, Messer R, Carmody A, Myers L, Dittmer U, et al. Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus. J Virol. 2008;82:408-18 pubmed
    ..Coinfection of mice with LDV and FV provides a well-defined, natural host model for such studies...
  31. Doig D, Chesebro B. Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production. J Exp Med. 1979;150:10-9 pubmed
    ..Rfv-3 did not influence an intrinsic ability of FV antigens to be modulated from Rfv-3s/s leukemia cells because FV antigen loss from Rfv-3s/s spleen cells occurred after transfer of cells to an immune environment...
  32. Dittmer U, Peterson K, Messer R, Stromnes I, Race B, Hasenkrug K. Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection. J Virol. 2001;75:654-60 pubmed
    ..The results indicate that IFN-gamma plays an important role during primary immune responses against Friend virus but is dispensable during vaccine-primed secondary responses...
  33. Hasenkrug K, Dittmer U. Immune control and prevention of chronic Friend retrovirus infection. Front Biosci. 2007;12:1544-51 pubmed
    ..Also summarized are findings from vaccine studies demonstrating the immunological requirements for the prevention of chronic retroviral infection. The implications of these findings for chronic infections in humans are discussed...
  34. Chesebro B, Wehrly K. Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979;76:425-9 pubmed
    ..Furthermore, backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response...
  35. Zelinskyy G, Balkow S, Schimmer S, Werner T, Simon M, Dittmer U. The level of friend retrovirus replication determines the cytolytic pathway of CD8+ T-cell-mediated pathogen control. J Virol. 2007;81:11881-90 pubmed
    ..levels in the induction and activation of CTL, including their effector potential, during acute Friend murine leukemia virus (F-MuLV) infection...
  36. Mitchell T, Risser R. Interference established in mice by infection with Friend murine leukemia virus. J Virol. 1992;66:5696-702 pubmed
    ..We established retroviral interference in mice by infecting them with Friend murine leukemia virus and them measured susceptibility to superinfection by challenging the mice with the ..
  37. Chesebro B, Wehrly K, Stimpfling J. Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex. J Exp Med. 1974;140:1457-67 pubmed
    ..The mechanisms of action of these genes remain unknown...
  38. Zelinskyy G, Dietze K, Hüsecken Y, Schimmer S, Nair S, Werner T, et al. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood. 2009;114:3199-207 pubmed publisher
  39. Browne E, Littman D. Myd88 is required for an antibody response to retroviral infection. PLoS Pathog. 2009;5:e1000298 pubmed publisher
    ..pathways in the generation of an anti-retroviral immune response against a mouse retroviral pathogen, Friend murine leukemia virus (F-MLV)...
  40. Manzke N, Akhmetzyanova I, Hasenkrug K, Trilling M, Zelinskyy G, Dittmer U. CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells. J Virol. 2013;87:6306-13 pubmed publisher
    ..Thus, both Tregs and CD8(+) T cells influence the cytotoxic activity of conventional CD4(+) T cells during an acute retroviral infection...
  41. Duley A, Ploquin M, Eksmond U, Ammann C, Messer R, Myers L, et al. Negative impact of IFN-γ on early host immune responses to retroviral infection. J Immunol. 2012;189:2521-9 pubmed publisher
    ..Results from this model reveal that IFN-γ production can have detrimental effects on early adaptive immune responses and virus control. ..
  42. Perryman S, Nishio J, Chesebro B. Complete nucleotide sequence of Friend murine leukemia virus, strain FB29. Nucleic Acids Res. 1991;19:6950 pubmed
  43. Iwashiro M, Kondo T, Shimizu T, Yamagishi H, Takahashi K, Matsubayashi Y, et al. Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. J Virol. 1993;67:4533-42 pubmed
    ..helper T-cell determinants on viral proteins was analyzed with recombinant vaccinia viruses expressing Friend murine leukemia virus (F-MuLV) gag or env genes or shorter fragments of the env gene...
  44. Hasenkrug K, Chesebro B. Immunity to retroviral infection: the Friend virus model. Proc Natl Acad Sci U S A. 1997;94:7811-6 pubmed
    ..In vivo depletion experiments demonstrate different requirements for CD8(+) T cells depending on the vaccine used. The implications of these studies for human retroviral diseases are discussed...
  45. Zelinskyy G, Balkow S, Schimmer S, Schepers K, Simon M, Dittmer U. Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection. Virology. 2004;330:365-74 pubmed
    ..These findings suggest novel pathways of CTL-mediated viral defense and contribute towards a better understanding of the molecular mechanisms of CTL activity in retroviral infections...
  46. Sugahara D, Tsuji Kawahara S, Miyazawa M. Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicity. J Virol. 2004;78:6322-34 pubmed
    ..We have previously demonstrated that immunization with Friend murine leukemia virus (F-MuLV) Gag proteins protects mice against the fatal Friend retrovirus (FV) infection...
  47. Hasenkrug K, Brooks D, Dittmer U. Critical role for CD4(+) T cells in controlling retrovirus replication and spread in persistently infected mice. J Virol. 1998;72:6559-64 pubmed
  48. Kitagawa M, Yamaguchi S, Hasegawa M, Tanaka K, Sado T, Hirokawa K, et al. Friend leukemia virus infection enhances DNA damage-induced apoptosis of hematopoietic cells, causing lethal anemia in C3H hosts. J Virol. 2002;76:7790-8 pubmed
  49. Santiago M, Benitez R, Montano M, Hasenkrug K, Greene W. Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. J Immunol. 2010;185:1114-23 pubmed publisher
    ..These findings raise the possibility that enabling Apobec3 activity during acute infection with human pathogenic retroviruses, such as HIV-1, may similarly facilitate stronger virus-specific neutralizing Ab responses...
  50. Miyazawa M, Tsuji Kawahara S, Kanari Y. Host genetic factors that control immune responses to retrovirus infections. Vaccine. 2008;26:2981-96 pubmed publisher
    ..Recent genetic analyses have indicated that a large proportion of such exposed but uninfected individuals may share a common genetic background...
  51. Nair S, Zelinskyy G, Schimmer S, Gerlach N, Kassiotis G, Dittmer U. Mechanisms of control of acute Friend virus infection by CD4+ T helper cells and their functional impairment by regulatory T cells. J Gen Virol. 2010;91:440-51 pubmed publisher
    ..The current study reveals that Th cells were critical for recovery from acute FV infection but were functionally impaired during the late phase of acute infection due to induced Tregs...
  52. Marques R, Antunes I, Eksmond U, Stoye J, Hasenkrug K, Kassiotis G. B lymphocyte activation by coinfection prevents immune control of friend virus infection. J Immunol. 2008;181:3432-40 pubmed
    ..Thus, immune activation by coinfecting pathogens or their products can contribute to the pathogenicity of retroviral infection...
  53. Hasenkrug K, Dittmer U. The role of CD4 and CD8 T cells in recovery and protection from retroviral infection: lessons from the Friend virus model. Virology. 2000;272:244-9 pubmed
  54. Hasenkrug K. Lymphocyte deficiencies increase susceptibility to friend virus-induced erythroleukemia in Fv-2 genetically resistant mice. J Virol. 1999;73:6468-73 pubmed
    ..Thus, Fv-2 resistance does not independently prevent FV-induced erythroleukemia but works in concert with the immune system by limiting early infection long enough to allow virus-specific immunity time to develop and facilitate recovery...
  55. Myers L, Hasenkrug K. Retroviral immunology: lessons from a mouse model. Immunol Res. 2009;43:160-6 pubmed publisher
    ..The FV model has provided insights into immunological mechanisms found to be relevant to human infections with retroviruses such as HIV-1 and HTLV-1...
  56. Tsuji Kawahara S, Chikaishi T, Takeda E, Kato M, Kinoshita S, Kajiwara E, et al. Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice. J Virol. 2010;84:6082-95 pubmed publisher
  57. Bordereaux D, Fichelson S, Sola B, Tambourin P, Gisselbrecht S. Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias. J Virol. 1987;61:4043-5 pubmed
    fim-3 is a new proviral integration region involved in 23% (16 of 68) of Friend murine leukemia virus-induced myeloblastic leukemias. This region is distinct from 20 oncogenes and from putative oncogenes tested so far...
  58. Ben David Y, Giddens E, Bernstein A. Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proc Natl Acad Sci U S A. 1990;87:1332-6 pubmed
    b>Friend murine leukemia virus (F-MuLV) induces erythroleukemia when inoculated into newborn BALB/c or NIH/Swiss mice...
  59. Chen W, Qin H, Chesebro B, Cheever M. Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors. J Virol. 1996;70:7773-82 pubmed
    FBL-3 is a highly immunogenic murine leukemia of C57BL/6 origin induced by Friend murine leukemia virus (MuLV)...
  60. Jung Y, Wu T, Kozak C. Novel host range and cytopathic variant of ecotropic Friend murine leukemia virus. J Virol. 2004;78:12189-97 pubmed
    A variant ecotropic Friend murine leukemia virus, F-S MLV, is capable of inducing the formation of large multinucleated syncytia in Mus dunni cells...
  61. Super H, Brooks D, Hasenkrug K, Chesebro B. Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice. J Virol. 1998;72:9400-3 pubmed
    ..These studies revealed the first evidence for a functional T-cell response following FV infection in these low-recovery mice and showed that CD4(+) T-helper cells are required for the Rfv-3-controlled FV antibody response...