abelson murine leukemia virus

Summary

Summary: A replication-defective strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with FRIEND MURINE LEUKEMIA VIRUS; MOLONEY MURINE LEUKEMIA VIRUS; or RAUSCHER VIRUS.

Top Publications

  1. Rovera G, Valtieri M, Mavilio F, Reddy E. Effect of Abelson murine leukemia virus on granulocytic differentiation and interleukin-3 dependence of a murine progenitor cell line. Oncogene. 1987;1:29-35 pubmed
    ..Infection with Abelson murine leukemia virus (A-MuLV) of 32D Cl3 cells growing in the presence of IL-3 induces, within 2 weeks, the appearance of ..
  2. Kajigaya S, Suda T, Suda J, Eguchi M, Moroi M, Sudo T, et al. Establishment of megakaryoblastic cell lines by coinfection of Abelson murine leukemia virus and recombinant SV40-retrovirus. Jpn J Cancer Res. 1988;79:726-33 pubmed
    Murine embryonic cells including yolk sac prepared from 8-day embryos were co-infected with Abelson murine leukemia virus (A-MuLV) and/or a recombinant retrovirus containing large T and small t antigens, and early region of simian virus ..
  3. Poirier Y, Kozak C, Jolicoeur P. Identification of a common helper provirus integration site in Abelson murine leukemia virus-induced lymphoma DNA. J Virol. 1988;62:3985-92 pubmed
    b>Abelson murine leukemia virus induces oligoclonal pre-B lymphoma in mice...
  4. Goff S, Gilboa E, Witte O, Baltimore D. Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell. 1980;22:777-85 pubmed
    Circular double-stranded DNA produced after infection of mouse cells with Abelson murine leukemia virus (A-MuLV) was isolated and cloned in the phage vector Charon 21A...
  5. Chen Y, Wang L, Huang M, Rosenberg N. An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev. 1994;8:688-97 pubmed
    Lymphoid cells transformed by Abelson murine leukemia virus have provided one of the classic models for study of early B-cell development and immunoglobulin rearrangement...
  6. Feddersen R, Van Ness B. Corrective recombination of mouse immunoglobulin kappa alleles in Abelson murine leukemia virus-transformed pre-B cells. Mol Cell Biol. 1990;10:569-76 pubmed
    ..to the formation of productive V-J genes through corrective recombinations, we have examined several Abelson murine leukemia virus-transformed pre-B-cell clones which rearrange the kappa locus during cell culture...
  7. Alt F, Rosenberg N, Enea V, Siden E, Baltimore D. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol. 1982;2:386-400 pubmed
    Lymphoid cells transformed by Abelson murine leukemia virus (A-MuLV) contain three classes of RNA transcripts from immunoglobulin mu genes. P mu-mRNAs (productive) correspond to the normal 2.7-kilobase (kb) membrane (mu m) and 2...
  8. Gourzi P, Leonova T, Papavasiliou F. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Immunity. 2006;24:779-86 pubmed
    ..we present evidence that AID is induced outside the germinal center in response to infection by the Abelson murine leukemia virus. The genotoxic activity of virally induced AID resulted in checkpoint kinase-1 (chk1) phosphorylation ..
  9. Poirier Y, Jolicoeur P. Distinct helper virus requirements for Abelson murine leukemia virus-induced pre-B- and T-cell lymphomas. J Virol. 1989;63:2088-98 pubmed
    b>Abelson murine leukemia virus (A-MuLV) can induce pre-B- or T-cell lymphomas (thymomas) in mice depending on the route and time of injection...

More Information

Publications99

  1. Weissinger E, Mischak H, Goodnight J, Davidson W, Mushinski J. Addition of constitutive c-myc expression to Abelson murine leukemia virus changes the phenotype of the cells transformed by the virus from pre-B-cell lymphomas to plasmacytomas. Mol Cell Biol. 1993;13:2578-85 pubmed
    b>Abelson murine leukemia virus (A-MuLV), a retrovirus that expresses the v-abl oncogene, characteristically induces pre-B-cell lymphomas following in vivo infection of BALB/c mice or in vitro infection of suspensions of fetal liver or ..
  2. Gourzi P, Leonova T, Papavasiliou F. Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med. 2007;204:259-65 pubmed
    ..Thus, induction of AID by viruses could be the result of several signaling pathways that culminate in NF-kappaB activation, underscoring the versatility of this host defense program...
  3. Zimmerman R, Rosenberg N. Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus. J Virol. 2008;82:8383-91 pubmed publisher
    Transformation by Abelson murine leukemia virus (Ab-MLV) is a multistep process in which growth-stimulatory signals from the v-Abl oncoprotein and growth-suppressive signals from the p19(Arf)-p53 tumor suppressor pathway oppose each ..
  4. Muljo S, Schlissel M. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat Immunol. 2003;4:31-7 pubmed
    b>Abelson murine leukemia virus-transformed cell lines have provided a critical model system for studying the regulation of B cell development...
  5. Nakamura Y, Grumont R, Gerondakis S. NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression. Mol Cell Biol. 2002;22:5563-74 pubmed
    ..Here we show that the proliferation and tumorigenicity of Abelson murine leukemia virus (A-MuLV)-transformed pre-B cells are enhanced in the absence of NF-kappaB1 and that this coincides ..
  6. Sugiyama H, Weber G, Silva S, Babonits M, Wiener F, Klein G. The accelerating role of Abelson murine leukemia virus in murine plasmacytoma development: in vitro infection of spleen cells generates donor-type tumors after transfer to pristane-treated BALB/c mice. Int J Cancer. 1989;44:348-52 pubmed
    The role of Abelson murine leukemia virus (A-MuLV) in the accelerated development of murine plasmacytomas (PCs) (Potter et al., 1973: Science, 132, 592-594) was studied in a new experimental system...
  7. Van de Ven W, Reynolds F, Stephenson J. The nonstructural components of polyproteins encoded by replication-defective mammalian transforming retroviruses are phosphorylated and have associated protein kinase activity. Virology. 1980;101:185-97 pubmed
  8. Juang J, Hoffmann F. Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity. Oncogene. 1999;18:5138-47 pubmed
    ..Modulation of Abi protein levels may be an important mechanism for regulating the level of Abl kinase activity in the cell. ..
  9. Malynn B, Blackwell T, Fulop G, Rathbun G, Furley A, Ferrier P, et al. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 1988;54:453-60 pubmed
    b>Abelson murine leukemia virus-transformed precursor B lymphocytes from scid (severe combined immunodeficient) mice, like A-MuLV transformants from normal mice, actively rearrange segments of their Ig heavy chain variable region gene ..
  10. Arai N, Nomura D, Yokota K, Wolf D, Brill E, Shohat O, et al. Immunologically distinct p53 molecules generated by alternative splicing. Mol Cell Biol. 1986;6:3232-9 pubmed
    ..Differential hybridization of the mRNA population of transformed fibroblastic or lymphoid cells with either the 96-bp synthetic oligonucleotide or the p53-M11 cDNA indicated that the various mRNA species are expressed in vivo. ..
  11. Joyce S, Sun R, Nathenson S. Mapping the orientation of an antigenic peptide bound in the antigen binding groove of H-2Kb using a monoclonal antibody. Biochem Biophys Res Commun. 1992;186:1449-54 pubmed
    ..This finding strongly supports the positioning of the N-terminus of N52-59 proximal to pocket A, thus, assuming an orientation parallel to the alpha 1 helix...
  12. Lemoine F, Dedhar S, Lima G, Eaves C. Transformation-associated alterations in interactions between pre-B cells and fibronectin. Blood. 1990;76:2311-20 pubmed
  13. Klein G. Dysregulation of lymphocyte proliferation by chromosomal translocations and sequential genetic changes. Bioessays. 2000;22:414-22 pubmed
    ..Using PCR to detect cells carrying such translocations is useful for tumor diagnosis, prognosis, and choice of therapy. ..
  14. Engelman A, Rosenberg N. bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation. Mol Cell Biol. 1990;10:4365-9 pubmed
  15. Han X, Wong P, Chung S. Chronic myeloproliferative disease induced by site-specific integration of Abelson murine leukemia virus-infected hemopoietic stem cells. Proc Natl Acad Sci U S A. 1991;88:10129-33 pubmed
    ..All recipients with the acute disease had stem-cell clones with random Abelson murine leukemia virus integration sites...
  16. Heisterkamp N, Groffen J, Stephenson J. The human v-abl cellular homologue. J Mol Appl Genet. 1983;2:57-68 pubmed
  17. Klinken S, Nicola N, Johnson G. In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin. Proc Natl Acad Sci U S A. 1988;85:8506-10 pubmed
  18. Marchlik E, Kalman R, Rosenberg N. Decreased virus population diversity in p53-null mice infected with weakly oncogenic Abelson virus. J Virol. 2005;79:11618-26 pubmed
    The Abelson murine leukemia virus (Ab-MLV), like other retroviruses that contain v-onc genes, arose following a recombination event between a replicating retrovirus and a cellular oncogene...
  19. Cooper J, Hunter T. Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. Mol Cell Biol. 1981;1:394-407 pubmed
    ..major site, in mouse 3T3 cells transformed by Rous sarcoma virus or by the further unrelated virus Abelson murine leukemia virus. A second phosphotyrosine-containing protein has been detected in both Rous sarcoma virus and Abelson ..
  20. Pan P, Lieber M, Teale J. The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus. Int Immunol. 1997;9:515-22 pubmed
    ..Therefore, if all three segments were accessible, RSS/coding end effects would not contribute to the ordered rearrangement of the IgH locus. ..
  21. Schiff Maker L, Burns M, Konopka J, Clark S, Witte O, Rosenberg N. Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules. J Virol. 1986;57:1182-6 pubmed
    Monoclonal antibodies specific for regions of the transforming protein of Abelson murine leukemia virus were prepared...
  22. Heuze F, Pardoll D, Diez E, Ezine S, Jotereau F. Molecular analysis of a pro-T cell clone transformed by Abelson-murine leukemia virus, displaying progressive gamma delta T cell receptor gene rearrangement and surface expression. Eur J Immunol. 1992;22:2077-84 pubmed
    We present a molecular analysis of T cell differentiation in a set of clones derived from in vitro Abelson murine leukemia virus (A-MuLV) infection of fetal liver cells...
  23. Chen L, Wu J, Shiau C, Chen J. Organization and promoter analysis of the zebrafish (Danio rerio) chemokine gene (CXC-64) promoter. Fish Physiol Biochem. 2010;36:511-521 pubmed publisher
    ..7 (mouse macrophage; Abelson murine leukemia virus transformed) and zfl (zebrafish liver) cells and then treated with 0, 10, 50, 100, and 200 ng/ml LPS, ..
  24. Gong L, Unnikrishnan I, Raghavan A, Parmar K, Rosenberg N. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. J Virol. 2004;78:1636-44 pubmed
    Suppression of apoptosis is an important feature of the Abelson murine leukemia virus (Ab-MLV) transformation process...
  25. Woodall C, Watt N, Clements G. Simple technique for detecting RNA viruses by PCR in single sections of wax embedded tissue. J Clin Pathol. 1993;46:276-7 pubmed
    ..Various tissues were used which had not been deliberately prepared for this purpose. In a simple procedure hot xylene dewaxing is followed by acid phenol extraction of RNA and RNA PCR. ..
  26. Rothman P, Li S, Gorham B, Glimcher L, Alt F, Boothby M. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts. Mol Cell Biol. 1991;11:5551-61 pubmed
    ..germ line epsilon transcripts (termed I epsilon transcripts) occurs at the transcriptional level in an Abelson murine leukemia virus-transformed pre-B-cell line. A 1...
  27. Oka T, Yutsudo M, Inoue H, Higuchi F, Hakura A. Characterization of flat revertants isolated from cells transformed by Abelson murine leukemia virus (Ab-MuLV). J Cell Physiol. 1990;145:428-33 pubmed
    Transformed Fisher rat fibroblast cell lines by Abelson murine leukemia virus frequently revert to the normal phenotype in usual culture conditions...
  28. Fessler S, Rosenberg N, Baughn L. SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus. J Virol. 2011;85:9239-42 pubmed publisher
    v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway...
  29. Donella Deana A, Monti E, Pinna L. Inhibition of tyrosine protein kinases by the antineoplastic agent adriamycin. Biochem Biophys Res Commun. 1989;160:1309-15 pubmed
    ..of polyGlu/Tyr (4:1) by tyrosine protein kinases either from spleen or expressed by the oncogene of Abelson murine leukemia virus. The dose dependent inhibition by adriamycin is accounted for by competition for the ATP binding site, ..
  30. Kameyama K, Mochizuki M, Tanaka K, Sugimoto K. Convenient plasmid for extrachromosomal DNA recombination in mouse cells. Biochem Biophys Res Commun. 1993;192:1327-33 pubmed
    ..We consider the vector, pMR1, to be convenient for the analysis of homologous and non-homologous recombinations. ..
  31. Takemori T, Mizuguchi J, Miyazoe I, Nakanishi M, Shigemoto K, Kimoto H, et al. Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells. EMBO J. 1990;9:2493-500 pubmed
    ..These results suggest that, during the differentiation from pre-B to mature B cells, the cells express two types of mu chain complexes which exhibit different structures as a whole and possess different signal transducing capacities. ..
  32. Goff S, D EUSTACHIO P, Ruddle F, Baltimore D. Chromosomal assignment of the endogenous proto-oncogene C-abl. Science. 1982;218:1317-9 pubmed
    b>Abelson murine leukemia virus (A-MuLV) is a replication-defective retrovirus that transforms lymphocytes of the B-cell lineage...
  33. Parmar K, Huebner R, Rosenberg N. Carboxyl-terminal determinants of Abelson protein important for lymphoma induction. J Virol. 1991;65:6478-85 pubmed
    ..Finally, the sequence of the variants encoding smaller Abelson proteins reveals that as few as 452 v-abl-encoded amino acids are required for rapid induction of Abelson disease. ..
  34. Kipreos E, Wang J. Reversible dependence on growth factor interleukin-3 in myeloid cells expressing temperature sensitive v-abl oncogene. Oncogene Res. 1988;2:277-84 pubmed
    b>Abelson murine leukemia virus (A-MuLV) has been shown to abrogate the requirement for growth factor interleukin-3 (IL-3) in a variety of hematopoietic cell lineages by a non-autocrine mechanism...
  35. Jenab Wolcott J, Rodriguez Correa D, Reitmair A, Mak T, Rosenberg N. The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation. Mol Cell Biol. 2000;20:8373-81 pubmed
    ..the effects of defective mismatch repair on the multistep process of pre-B-cell transformation by Abelson murine leukemia virus. In this model, primary transformants undergo a prolonged apoptotic crisis followed by the emergence ..
  36. Peacock R, Lawhorn I, Ferreira J, Wang C. Flow cytometry of v-Abl transformed pre-B cells heterogeneous in ectopic expression levels reveals Ras dose-response. J Immunol Methods. 2012;384:177-83 pubmed publisher
    ..To make this analytical method widely available to others, we have provided a software application that performs LOWESS on any two-parameter population data collected by flow cytometry. ..
  37. Zeff R. Molecular mediators and events associated with attenuated MHC class I gene expression. Semin Cancer Biol. 1991;2:287-93 pubmed
    ..The regulated expression of H-2 antigens from these somatic cell variants is discussed in relationship to the mechanisms of attenuated MHC class I gene expression described for other leukemias. ..
  38. Fulop G, Bosma G, Bosma M, Phillips R. Early B-cell precursors in scid mice: normal numbers of cells transformable with Abelson murine leukemia virus (A-MuLV). Cell Immunol. 1988;113:192-201 pubmed
    ..scid mice have any B-cell precursors, we looked for pre-B cells by their ability to be transformed by Abelson murine leukemia virus (A-MuLV)...
  39. Palumbo G, Ozanne B, Kettman J. Multiple steps in the immortalization of cells of the B lineage. Leuk Res. 1991;15:847-58 pubmed
    ..Models are presented to account for the factor-dependent in vitro transformation of pre-B cells. ..
  40. Noronha E, Sterling K, Calame K. Increased expression of Bcl-xL and c-Myc is associated with transformation by Abelson murine leukemia virus. J Biol Chem. 2003;278:50915-22 pubmed
    Transformation mediated by the v-Abl oncoprotein, a tyrosine kinase encoded by the Abelson murine leukemia virus, is a multi-step process requiring genetic alterations in addition to expression of v-Abl...
  41. Lugo T, Witte O. The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc. Mol Cell Biol. 1989;9:1263-70 pubmed
    ..Thus, Rat-1 cells can be used to detect cooperation between BCR-ABL and other oncogenes and may prove useful for the identification of secondary oncogenic events in chronic myelogenous leukemia. ..
  42. Klinken S, Holmes K, Fredrickson T, Erner S, Morse H. Phenylhydrazine stimulates lymphopoiesis and accelerates Abelson murine leukemia virus-induced pre-B cell lymphomas. J Immunol. 1987;139:3091-8 pubmed
    Infection of bone marrow or fetal liver cells with Abelson murine leukemia virus (A-MuLV) results in the transformation of pre-B cells and the development of erythroid colonies, indicating that the abl oncogene can affect the growth ..
  43. Saez E, Oppenheim H, Smoluk J, Andersen J, Van Etten R, Spiegelman B. c-fos is not essential for v-abl-induced lymphomagenesis. Cancer Res. 1995;55:6196-9 pubmed
    ..c-fos proto-oncogene for v-abl-induced cancer development, we inoculated c-fos-deficient mice with the Abelson murine leukemia virus. Neonatal c-fos-deficient mice infected with the Abelson complex are able to develop the pre-B-cell ..
  44. Renshaw M, Kipreos E, Albrecht M, Wang J. Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context. EMBO J. 1992;11:3941-51 pubmed
    The v-abl oncogene of Abelson murine leukemia virus (A-MuLV) induces two opposite phenotypes in NIH3T3 cells...
  45. Hsieh C, McCloskey R, Lieber M. V(D)J recombination on minichromosomes is not affected by transcription. J Biol Chem. 1992;267:15613-9 pubmed
  46. Mostecki J, Halgren A, Radfar A, Sachs Z, Ravitz J, Thome K, et al. Loss of heterozygosity at the Ink4a/Arf locus facilitates Abelson virus transformation of pre-B cells. J Virol. 2000;74:9479-87 pubmed
    ..tumor suppressor genes, p53 and the Ink4a/Arf locus, play central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV) transformation...
  47. Keller J, Ruscetti S, Ruscetti F. Introduction of v-abl oncogene induces monocytic differentiation of an IL-3-dependent myeloid progenitor cell line. Oncogene. 1990;5:549-55 pubmed
    ..In this report, we demonstrate that the introduction and expression of Abelson murine leukemia virus into a myeloblast progenitor cell line can promote further differentiation along the monocytic lineage...
  48. Dale B, Ozanne B. Characterization of mouse cellular deoxyribonucleic acid homologous to Abelson murine leukemia virus-specific sequences. Mol Cell Biol. 1981;1:731-42 pubmed
    The genome of Abelson murine leukemia virus (A-MuLV) consists of sequences derived from both BALB/c mouse deoxyribonucleic acid and the genome of Moloney murine leukemia virus...
  49. Bailey S, Rosenberg N. Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light-chain gene rearrangement. Mol Cell Biol. 1997;17:887-94 pubmed
    ..gene rearrangements were induced in pre-B cells transformed by temperature-sensitive mutants of Abelson murine leukemia virus and PCR was used to identify interlocus recombinants...
  50. Schuler W, Weiler I, Schuler A, Phillips R, Rosenberg N, Mak T, et al. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell. 1986;46:963-72 pubmed
    ..However, rearrangements were detected in Abelson murine leukemia virus-transformed bone marrow cells and in spontaneous thymic lymphomas from C.B-17scid mice...
  51. Shilo B, Weinberg R. DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1981;78:6789-92 pubmed
    ..It seems likely that sequences homologous to vertebrate oncogenes play a crucial role in metazoan metabolism...
  52. Kruse C, Holden K, Offen P, Pritchard M, Feild J, Rieman D, et al. Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 2. J Med Chem. 1988;31:1768-72 pubmed
    ..Testing against p60v-abl, the tyrosine kinase from the Abelson murine leukemia virus, showed that the series of inhibitors was moderately potent (IC50 values as low as 13 microM)...
  53. Shore S, Bogart S, Reddy E. Activation of murine c-abl protooncogene: effect of a point mutation on oncogenic activation. Proc Natl Acad Sci U S A. 1990;87:6502-6 pubmed
    Activation of the c-abl protooncogene occurs in Abelson murine leukemia virus, in Hardy-Zuckerman 2 feline sarcoma virus, and during the chromosomal translocations that generate BCR-ABL gene fusion products...
  54. Pillemer E, Whitlock C, Weissman I. Transformation-associated proteins in murine B-cell lymphomas that are distinct from Abelson virus gene products. Proc Natl Acad Sci U S A. 1984;81:4434-8 pubmed
    In an effort to identify cellular proteins that may be involved in the Abelson murine leukemia virus (A-MuLV) transformation process, we have isolated a hybridoma antibody (6C3) that detects a tumor-associated antigen in all A-MuLV-..
  55. Shen Ong G, Wolff L. Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice: requirement of c-myb activation but lack of v-abl involvement. J Virol. 1987;61:3721-5 pubmed
    ..Our results also indicate that tumor-specific alteration at the 5' end of the myb gene plays an important role in the development of these tumors...
  56. Nussenzweig M, Schmidt E, Shaw A, Sinn E, Campos Torres J, Mathey Prevot B, et al. A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature. 1988;336:446-50 pubmed
    ..This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene...
  57. Majone F, Montaldi A, Saggioro D, Bianchi L, Levis A. Sister chromatid exchanges and chromosomal aberrations in mouse cells infected with the Abelson and Moloney leukemia viruses. Carcinogenesis. 1988;9:1229-31 pubmed
    ..chromatid breaks were scored in ANN-1 fibroblasts, a non-producer mouse cell line transformed by the Abelson murine leukemia virus (A-MuLV), a replication defective retrovirus whose genome contains the v-abl oncogene...
  58. Schlissel M, Kuo T. AID for innate immunity to retroviral transformation. Immunity. 2006;24:671-2 pubmed
    ..In this issue of Immunity, Gourzi et al. (2006) show that AID also plays a critical role in innate immunity to virally induced acute pro-B cell leukemia...
  59. Chung S, Wong P, Durkin H, Wu Y, Petersen J. Leukemia initiated by hemopoietic stem cells expressing the v-abl oncogene. Proc Natl Acad Sci U S A. 1991;88:1585-9 pubmed
    ..Fetal liver hemopoietic cells were infected with a high titer of helper-free Abelson murine leukemia virus (A-MuLV) and were used to reconstitute lethally irradiated mice...
  60. Brown E, Iqbal M, Stuart S, Hatton K, Valinsky J, Schildkraut C. Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon. Mol Cell Biol. 1987;7:450-7 pubmed
    ..6). In contrast, we observed that IgCh segments in a B-cell plasmacytoma (MPC11) and two Abelson murine leukemia virus-transformed pre-B cell lines (22D6 and 300-19O) replicated as early as (300-19P) or earlier than (..
  61. Vitiello A, Potter T, Sherman L. The role of beta 2-microglobulin in peptide binding by class I molecules. Science. 1990;250:1423-6 pubmed
    ..Thus, class I molecules on normal cells do not spontaneously bind or exchange peptides...
  62. Lemoine F, Krystal G, Humphries R, Eaves C. Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines. Cancer Res. 1988;48:6438-43 pubmed
    ..tested the ability of a spontaneous pre-B-cell transformant (H9 cells) and two independently derived Abelson murine leukemia virus transformed pre-B-cell lines to produce pre-B-cell stimulating factors...
  63. Shaulsky G, Goldfinger N, Peled A, Rotter V. Involvement of wild-type p53 in pre-B-cell differentiation in vitro. Proc Natl Acad Sci U S A. 1991;88:8982-6 pubmed
    ..Reconstitution of wild-type p53 in the p53-nonproducer, Abelson murine leukemia virus-transformed pre-B-cell line L12 gave rise to stably growing clones...
  64. Dyall Smith D, Cory S. Transformation of bone marrow cells from E mu-myc transgenic mice by Abelson murine leukemia virus and Harvey murine sarcoma virus. Oncogene Res. 1988;2:403-9 pubmed
    ..from E mu-myc mice and their normal littermates for transformation by Harvey murine sarcoma virus and Abelson murine leukemia virus. E mu-myc bone marrow yielded more lymphoid colonies than normal marrow after infection with Harvey ..
  65. Sarthou P, Jouvain Marche E, Cazenave P, Le Guern C. Phorbol ester induces class II gene expression in pre-B cell lines. Eur J Immunol. 1987;17:1375-8 pubmed
    ..on the induction of major histocompatibility complex class II gene expression was studied in four Abelson murine leukemia virus-transformed pre-B cell lines. In three cell lines, low concentrations of PMA (0...
  66. Unnikrishnan I, Rosenberg N. Absence of p53 complements defects in Abelson murine leukemia virus signaling. J Virol. 2003;77:6208-15 pubmed
    The v-Abl protein encoded by Abelson murine leukemia virus (Ab-MLV) induces transformation of pre-B cells via a two-stage process...
  67. Jhanwar S, Neel B, Hayward W, Chaganti R. Localization of the cellular oncogenes ABL, SIS, and FES on human germ-line chromosomes. Cytogenet Cell Genet. 1984;38:73-5 pubmed
    ..positions of the oncogenes ABL, SIS, and FES, the cellular counterparts of the v-onc genes of Abelson murine leukemia virus, simian sarcoma virus, and feline sarcoma virus, respectively, have been determined by in situ ..
  68. Rosson D, Reddy E. Activation of the abl oncogene and its involvement in chromosomal translocations in human leukemia. Mutat Res. 1988;195:231-43 pubmed
    ..The abl oncogene as first identified on the Abelson murine leukemia virus (A-MuLV)...
  69. Daley G, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci U S A. 1988;85:9312-6 pubmed
    ..Unlike the related P160gag/v-abl oncogene product of Abelson murine leukemia virus, P210bcr/abl does not transform NIH 3T3 fibroblasts...
  70. Warren D, Heilpern A, Berg K, Rosenberg N. The carboxyl terminus of v-Abl protein can augment SH2 domain function. J Virol. 2000;74:4495-504 pubmed
    b>Abelson murine leukemia virus (Ab-MLV) transforms NIH 3T3 and pre-B cells via expression of the v-Abl tyrosine kinase...
  71. Mysliwiec T, Perego R, Kruh G. Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain. Oncogene. 1996;12:631-40 pubmed
    ..These observations indicate that the C-terminal domain regulates Arg biological activity in a manner distinct from c-Abl and suggest that this effect may be mediated in part by SH3 domain-binding sites...
  72. Parmar K, Rosenberg N. Ras complements the carboxyl terminus of v-Abl protein in lymphoid transformation. J Virol. 1996;70:1009-15 pubmed
    b>Abelson murine leukemia virus (Ab-MLV) mutants expressing v-Abl proteins lacking the carboxyl terminus are compromised in the ability to transform lymphoid but not NIH 3T3 cells...
  73. Saggioro D, D Andrea E, Chieco Bianchi L. In vitro immune-receptor gene rearrangements in clonal thymic lymphomas induced by Abelson murine leukemia virus. Tumori. 1989;75:341-4 pubmed
    ..Since the recombination mechanism is operative only in very immature lymphoid cells, these data provide indirect evidence for the lack of differentiation of A-MuLV cell targets in the thymus...
  74. Rosenberg N, Witte O. The viral and cellular forms of the Abelson (abl) oncogene. Adv Virus Res. 1988;35:39-81 pubmed
    ..Future progress will certainly depend on the intensive efforts by many workers in the broader field of cellular growth control mechanisms...
  75. Holland G, Ito K, Kaehler D, Tonegawa S, Risser R. Thymic targets for Abelson murine leukemia virus are early gamma/delta T lymphocytes. Proc Natl Acad Sci U S A. 1991;88:3700-4 pubmed
    Molecular analysis has shown that the majority of Abelson murine leukemia virus (Ab-MuLV)-induced primary thymomas represent transformed gamma/delta thymocytes...
  76. Zeff R, Zhao Y, Tatake R, Lachman H, Borriello F, Nathenson S. Cis- and trans-repression of class I major histocompatibility gene expression in Abelson virus-transformed murine leukemia. Blood. 1991;78:524-32 pubmed
    ..Such findings indicate that downregulation of MHC class I gene expression is constitutive for the R8 leukemic cell line, a phenomenon that may be related to the immature pre-B-cell phenotype of this A-MuLV transformant...
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