gibbon ape leukemia virus

Summary

Summary: A species of GAMMARETROVIRUS causing leukemia in the gibbon ape. Natural transmission is by contact.

Top Publications

  1. Olah Z, Lehel C, Anderson W, Eiden M, Wilson C. The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter. J Biol Chem. 1994;269:25426-31 pubmed
    The primate type C retrovirus gibbon ape leukemia virus (GaLV) has been shown to use a widely expressed, multiple membrane-spanning protein of unknown function as its cell surface receptor on human cells (GLVR1) (Johann, S. V...
  2. Kiem H, Heyward S, Winkler A, Potter J, Allen J, Miller A, et al. Gene transfer into marrow repopulating cells: comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons. Blood. 1997;90:4638-45 pubmed
    ..from amphotropic murine retrovirus with similar vectors having an envelope protein derived from gibbon ape leukemia virus (GALV)...
  3. Chen J, Reeves L, Cornetta K. Safety testing for replication-competent retrovirus associated with gibbon ape leukemia virus-pseudotyped retroviral vectors. Hum Gene Ther. 2001;12:61-70 pubmed
    ..Pseudotyped vectors using the gibbon ape leukemia virus (GALV) envelope have entered into clinical trials but specific recommendations regarding methods for ..
  4. Stitz J, Wolfrum N, Buchholz C, Cichutek K. Envelope proteins of spleen necrosis virus form infectious human immunodeficiency virus type 1 pseudotype vector particles, but fail to incorporate upon substitution of the cytoplasmic domain with that of Gibbon ape leukemia virus. J Gen Virol. 2006;87:1577-81 pubmed
    ..chimeric SNV-derived Env proteins encompassing wt and engineered cytoplasmic domains (C-tail) of the Gibbon ape leukemia virus (GaLV) TM protein, it was further shown that the wt C-tail not only excludes the GaLV TM protein from ..
  5. Merten C, Stitz J, Braun G, Poeschla E, Cichutek K, Buchholz C. Directed evolution of retrovirus envelope protein cytoplasmic tails guided by functional incorporation into lentivirus particles. J Virol. 2005;79:834-40 pubmed
    In contrast to most gammaretrovirus envelope proteins (Env), the Gibbon ape leukemia virus (GaLV) Env protein does not mediate the infectivity of human immunodeficiency virus type 1 (HIV-1) particles...
  6. Lamers C, Willemsen R, van Elzakker P, Gratama J, Debets R. Gibbon ape leukemia virus poorly replicates in primary human T lymphocytes: implications for safety testing of primary human T lymphocytes transduced with GALV-pseudotyped vectors. J Immunother. 2009;32:272-9 pubmed publisher
    ..We assessed the sensitivity of the "extended PG4(S+L-) assay" to detect gibbon ape leukemia virus (GALV) RCR, and applied this assay to measure GALV RCR spread in retrovirally transduced T cells...
  7. Farrell K, Tusnady G, Eiden M. New structural arrangement of the extracellular regions of the phosphate transporter SLC20A1, the receptor for gibbon ape leukemia virus. J Biol Chem. 2009;284:29979-87 pubmed publisher
    ..For numerous gammaretroviruses, such as the gibbon ape leukemia virus, woolly monkey virus, feline leukemia virus subgroup B, feline leukemia virus subgroup T, and 10A1 ..
  8. Lucas T, Lyddon T, Cannon P, Johnson M. Pseudotyping incompatibility between HIV-1 and gibbon ape leukemia virus Env is modulated by Vpu. J Virol. 2010;84:2666-74 pubmed publisher
    The Env protein from gibbon ape leukemia virus (GaLV) has been shown to be incompatible with human immunodeficiency virus type 1 (HIV-1) in the production of infectious pseudotyped particles...
  9. Ting Y, Wilson C, Farrell K, Chaudry G, Eiden M. Simian sarcoma-associated virus fails to infect Chinese hamster cells despite the presence of functional gibbon ape leukemia virus receptors. J Virol. 1998;72:9453-8 pubmed
    We have sequenced the envelope genes from each of the five members of the gibbon ape leukemia virus (GALV) family of type C retroviruses...

More Information

Publications80

  1. Tailor C, Takeuchi Y, O HARA B, Johann S, Weiss R, Collins M. Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections. J Virol. 1993;67:6737-41 pubmed
    The three type C retroviruses, gibbon ape leukemia virus (GALV), simian sarcoma-associated virus (SSAV), and feline leukemia virus subgroup B (FeLV-B), infect human cells by interacting with the same cell surface receptor, GLVR1...
  2. Miller D, Edwards R, Miller A. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Proc Natl Acad Sci U S A. 1994;91:78-82 pubmed
    ..The 656-amino acid receptor is homologous to the gibbon ape leukemia virus receptor at both hydrophobic termini but is highly divergent in the central hydrophilic region...
  3. Hanger J, Bromham L, McKee J, O Brien T, Robinson W. The nucleotide sequence of koala (Phascolarctos cinereus) retrovirus: a novel type C endogenous virus related to Gibbon ape leukemia virus. J Virol. 2000;74:4264-72 pubmed
    ..not detected in other marsupials, and phylogenetic analysis showed that KoRV paradoxically clusters with gibbon ape leukemia virus (GALV)...
  4. Stitz J, Buchholz C, Engelstädter M, Uckert W, Bloemer U, Schmitt I, et al. Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1. Virology. 2000;273:16-20 pubmed
    ..the Env of the molecular clone 10A1 of MLV and with chimeric envelope glycoprotein variants derived from gibbon ape leukemia virus (GaLV) and MLV...
  5. Pedersen L, Johann S, van Zeijl M, Pedersen F, O HARA B. Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirus. J Virol. 1995;69:2401-5 pubmed
    Glvr1 encodes the human receptor for gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B), while the related gene Glvr2 encodes the human receptor for amphotropic murine leukemia viruses (A-MLVs)...
  6. Demaison C, Brouns G, Blundell M, Goldman J, Levinsky R, Grez M, et al. A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus-pseudotyped retroviral vector. Hum Gene Ther. 2000;11:91-100 pubmed
    ..This adds to the emerging evidence of heterogeneity within the SRC compartment, and has important implications for the interpretation of this assay in stem cell transplantation and gene transfer studies...
  7. Wolgamot G, Bonham L, Miller A. Sequence analysis of Mus dunni endogenous virus reveals a hybrid VL30/gibbon ape leukemia virus-like structure and a distinct envelope. J Virol. 1998;72:7459-66 pubmed
    ..those of VL30 elements, while the majority of the coding sequences are most closely related to those of gibbon ape leukemia virus. MDEV represents the first example of a naturally occurring, replication-competent virus with sequences ..
  8. Christodoulopoulos I, Cannon P. Sequences in the cytoplasmic tail of the gibbon ape leukemia virus envelope protein that prevent its incorporation into lentivirus vectors. J Virol. 2001;75:4129-38 pubmed
    ..Env proteins from several different subtypes of murine leukemia virus (MuLV), the related protein from gibbon ape leukemia virus (GaLV) does not form functional pseudotypes...
  9. Farrell K, Ting Y, Eiden M. Fusion-defective gibbon ape leukemia virus vectors can be rescued by homologous but not heterologous soluble envelope proteins. J Virol. 2002;76:4267-74 pubmed
    ..We have now constructed functional immunologically reactive gibbon ape leukemia virus (GALV) envelope proteins, tagged with a feline leukemia virus (FeLV)-derived epitope tag, which are ..
  10. Pedersen L, van Zeijl M, Johann S, O HARA B. Fungal phosphate transporter serves as a receptor backbone for gibbon ape leukemia virus. J Virol. 1997;71:7619-22 pubmed
    Pit1, the receptor for gibbon ape leukemia virus (GALV), is proposed to be an integral membrane protein with five extracellular loops...
  11. Wilson C, Eiden M, Anderson W, Lehel C, Olah Z. The dual-function hamster receptor for amphotropic murine leukemia virus (MuLV), 10A1 MuLV, and gibbon ape leukemia virus is a phosphate symporter. J Virol. 1995;69:534-7 pubmed
    ..a receptor not only for amphotropic murine leukemia viruses and 10A1 murine leukemia virus but also for gibbon ape leukemia virus (C.A. Wilson, K. B. Farrell, and M. V. Eiden, J. Virol. 68:7697-7703, 1994)...
  12. van Zeijl M, Johann S, Closs E, Cunningham J, Eddy R, Shows T, et al. A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family. Proc Natl Acad Sci U S A. 1994;91:1168-72 pubmed
    ..we have identified a human cDNA clone encoding a protein closely related to the receptor for gibbon ape leukemia virus and have found that it functions as the receptor for the amphotropic group of murine retroviruses...
  13. Eiden M, Farrell K, Wilson C. Substitution of a single amino acid residue is sufficient to allow the human amphotropic murine leukemia virus receptor to also function as a gibbon ape leukemia virus receptor. J Virol. 1996;70:1080-5 pubmed
    ..the human form of the A-MuLV receptor (PiT2), functions as a receptor not only for A-MuLVs but also for gibbon ape leukemia virus (GALV)...
  14. Lam J, Reeves M, Cowherd R, Rosenberg S, Hwu P. Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope. Hum Gene Ther. 1996;7:1415-22 pubmed
    ..One such alternative retroviral envelope, the gibbon ape leukemia virus (GALV) envelope, targets a distinct surface receptor (GLVR-1) that is 60% homologous but not cross-..
  15. Chaudry G, Farrell K, Ting Y, Schmitz C, Lie S, Petropoulos C, et al. Gibbon ape leukemia virus receptor functions of type III phosphate transporters from CHOK1 cells are disrupted by two distinct mechanisms. J Virol. 1999;73:2916-20 pubmed
    ..E36 and CHOK1 dramatically differ in susceptibility to amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GALV); E36 cells are highly susceptible to both viruses, CHOK1 cells are not...
  16. Johann S, van Zeijl M, Cekleniak J, O HARA B. Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species. J Virol. 1993;67:6733-6 pubmed
    Expression of human GLVR1 in mouse cells confers susceptibility to infection by gibbon ape leukemia virus (GALV), while the normally expressed mouse Glvr-1 does not...
  17. Eglitis M, Schneiderman R, Rice P, Eiden M. Evaluation of retroviral vectors based on the gibbon ape leukemia virus. Gene Ther. 1995;2:486-92 pubmed
    ..These results suggest that judicious combinations of retroviral genomes and structural components can significantly improve gene transfer into human cells...
  18. van der Loo J, Liu B, Goldman A, Buckley S, Chrudimsky K. Optimization of gene transfer into primitive human hematopoietic cells of granulocyte-colony stimulating factor-mobilized peripheral blood using low-dose cytokines and comparison of a gibbon ape leukemia virus versus an RD114-pseudotyped retroviral v. Hum Gene Ther. 2002;13:1317-30 pubmed
    ..Finally, using our best condition based on transduction with the gibbon ape leukemia virus (GaLV)-pseudotyped vector, we demonstrate a 33-fold higher level of gene transfer (p < 0...
  19. Kavanaugh M, Miller D, Zhang W, Law W, Kozak S, Kabat D, et al. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A. 1994;91:7071-5 pubmed
    Cell surface receptors for gibbon ape leukemia virus (Glvr-1) and murine amphotropic retrovirus (Ram-1) are distinct but related proteins having multiple membrane-spanning regions...
  20. Kirkham L, Bateman A, Melcher A, Vile R, Fielding A. Lack of specificity of cell-surface protease targeting of a cytotoxic hyperfusogenic gibbon ape leukaemia virus envelope glycoprotein. J Gene Med. 2002;4:592-600 pubmed
  21. Farrell K, Eiden M. Dissection of gammaretroviral receptor function by using type III phosphate transporters as models. J Virol. 2005;79:9332-6 pubmed
    ..A notable exception is gibbon ape leukemia virus (GALV). Fusion-impaired GALV envelope mutants can be trans-activated for infectivity only by GALV RBDs...
  22. Johnson K, Peng K, Allen C, Russell S, Galanis E. Targeting the cytotoxicity of fusogenic membrane glycoproteins in gliomas through protease-substrate interaction. Gene Ther. 2003;10:725-32 pubmed
    ..Expression constructs were made expressing the hyperfusogenic version of the Gibbon Ape Leukemia Virus envelope glycoprotein (GALV) linked to a blocking ligand (the C-terminal extracellular domain of CD40 ..
  23. Koren B, Weisz A, Fischer L, Gluzman Z, Preis M, Avramovitch N, et al. Efficient transduction and seeding of human endothelial cells onto metallic stents using bicistronic pseudo-typed retroviral vectors encoding vascular endothelial growth factor. Cardiovasc Revasc Med. 2006;7:173-8 pubmed
    ..Efficiency of gene transfer to human ECs using an amphotropic retroviral vector and a gibbon ape leukemia virus (GALV) pseudo-typed retroviral vector was examined and compared...
  24. Tarlinton R, Meers J, Young P. Biology and evolution of the endogenous koala retrovirus. Cell Mol Life Sci. 2008;65:3413-21 pubmed publisher
    ..Part of a multi-author review)...
  25. Gallo R. A journey with T cells, primate/human retroviruses and other persisting human T-cell tropic viruses. Rev Clin Exp Hematol. 2003;7:329-35 pubmed
    ..the Hall's Island strain of gibbon ape leukemia virus, 2. HTLV-1, 3. HTLV-2, 4. human immunodeficiency virus and 5. human herpes virus-6 (HHV-6)...
  26. Horn P, Topp M, Morris J, Riddell S, Kiem H. Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells. Blood. 2002;100:3960-7 pubmed
    ..Thus, we generated a human packaging cell line with a gibbon ape leukemia virus pseudotype (Phoenix-GALV), and we evaluated vectors produced by Phoenix-GALV for their ability to ..
  27. Chono H, Yoshioka H, Ueno M, Kato I. Removal of inhibitory substances with recombinant fibronectin-CH-296 plates enhances the retroviral transduction efficiency of CD34(+)CD38(-) bone marrow cells. J Biochem. 2001;130:331-4 pubmed
    ..5 and 71.1%, respectively. ..
  28. Holic N, Fenard D. Production of Retrovirus-Based Vectors in Mildly Acidic pH Conditions. Methods Mol Biol. 2016;1448:41-8 pubmed publisher
    ..to threefold the production of RVs and LVs pseudotyped with the vesicular stomatitis virus G (VSV-G) or gibbon ape leukemia virus (GALV) glycoproteins...
  29. Guedan S, Gros A, Cascallo M, Vile R, Mercade E, Alemany R. Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication. Gene Ther. 2008;15:1240-5 pubmed publisher
    ..We have inserted the hyperfusogenic form of the gibbon ape leukemia virus (GALV) envelope glycoprotein as a new splice unit of the major late promoter (MLP) to generate a ..
  30. Grabarczyk P, Wysocki P, Gryska K, Mackiewicz A. Expression of PiT1 and PiT2 retroviral receptors and transduction efficiency of tumor cells. Acta Biochim Pol. 2002;49:333-9 pubmed
    ..constructed bicistronic retroviral vector pseudotypes of amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GaLV), encoding enhanced green fluorescent protein (EGFP) as a rapid and easily detectable reporter ..
  31. Moon N, Yang S, Park B, Chung Y, Lee J, Oh I. Efficient bone marrow transduction by gene transfer with allogeneic umbilical cord blood serum and plasma: an implication for clinical trials. Hum Gene Ther. 2008;19:744-52 pubmed publisher
    ..stabilization of retroviral particles than SFM during in vitro culture of retrovirus pseudotyped with gibbon ape leukemia virus or vesicular stomatitis virus glycoprotein...
  32. Chute J, Saini A, Wells M, Clark W, Wu A, St Louis D, et al. Preincubation with endothelial cell monolayers increases gene transfer efficiency into human bone marrow CD34(+)CD38(-) progenitor cells. Hum Gene Ther. 2000;11:2515-28 pubmed
  33. Hombach A, Schneider C, Sent D, Koch D, Willemsen R, Diehl V, et al. An entirely humanized CD3 zeta-chain signaling receptor that directs peripheral blood t cells to specific lysis of carcinoembryonic antigen-positive tumor cells. Int J Cancer. 2000;88:115-20 pubmed
    ..Upon co-culture with CEA(+) tumor cells, receptor-grafted T cells are specifically and efficiently activated to cytolysis and IFN-gamma secretion, demonstrating their feasibility for the adoptive immunotherapy of CEA(+) carcinomas. ..
  34. Allen C, McDonald C, Giannini C, Peng K, Rosales G, Russell S, et al. Adenoviral vectors expressing fusogenic membrane glycoproteins activated via matrix metalloproteinase cleavable linkers have significant antitumor potential in the gene therapy of gliomas. J Gene Med. 2004;6:1216-27 pubmed
    Fusogenic membrane glycoproteins (FMG) such as the gibbon ape leukemia virus envelope (GALV) glycoprotein are potent therapeutic transgenes with potential utility in the gene therapy of gliomas...
  35. Farrell K, Russ J, Murthy R, Eiden M. Reassessing the role of region A in Pit1-mediated viral entry. J Virol. 2002;76:7683-93 pubmed
    The mammalian gammaretroviruses gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B) can use the same receptor, Pit1, to infect human cells...
  36. Denner J. Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV) and the Koala Retrovirus (KoRV). Viruses. 2016;8: pubmed publisher
    ..g., that of porcine endogenous retroviruses (PERVs) during xenotransplantation using pig cells, tissues or organs. ..
  37. Alfano N, Michaux J, Morand S, Aplin K, Tsangaras K, Löber U, et al. Endogenous Gibbon Ape Leukemia Virus Identified in a Rodent (Melomys burtoni subsp.) from Wallacea (Indonesia). J Virol. 2016;90:8169-80 pubmed publisher
    b>Gibbon ape leukemia virus (GALV) and koala retrovirus (KoRV) most likely originated from a cross-species transmission of an ancestral retrovirus into koalas and gibbons via one or more intermediate as-yet-unknown hosts...
  38. Kiem H, McSweeney P, Bruno B, Goerner M, Buron G, Morris J, et al. Improved gene transfer into canine hematopoietic repopulating cells using CD34-enriched marrow cells in combination with a gibbon ape leukemia virus-pseudotype retroviral vector. Gene Ther. 1999;6:966-72 pubmed
    ..Furthermore, these results demonstrate that the monoclonal antibody to canine CD34 used in this study is able to enrich for hematopoietic repopulating cells. ..
  39. Schneiderman R, Farrell K, Wilson C, Eiden M. The Japanese feral mouse Pit1 and Pit2 homologs lack an acidic residue at position 550 but still function as gibbon ape leukemia virus receptors: implications for virus binding motif. J Virol. 1996;70:6982-6 pubmed
    Murine cells are typically resistant to gibbon ape leukemia virus (GALV). MMMol, a Japanese feral mouse cell line, is an exception in that these cells are susceptible to infection by GALV...
  40. Tan L, Xu B, Liu R, Liu H, Tan H, Huang W. Gene therapy for acute myeloid leukemia using Sindbis vectors expressing a fusogenic membrane glycoprotein. Cancer Biol Ther. 2010;9:350-7 pubmed
    ..It was previously shown that the expression of gene coding for the hyperfusogenic gibbon ape leukemia virus envelope glycoprotein (GALV.fus) can efficiently kill leukemic cells...
  41. Gallardo H, Tan C, Ory D, Sadelain M. Recombinant retroviruses pseudotyped with the vesicular stomatitis virus G glycoprotein mediate both stable gene transfer and pseudotransduction in human peripheral blood lymphocytes. Blood. 1997;90:952-7 pubmed
    ..This goal is achieved by using recombinant retroviruses pseudotyped with either the gibbon ape leukemia virus (GaLV) envelope or the vesicular stomatitis virus G (VSV-G) glycoprotein...
  42. Wong S, Swanson R, Bergquam E. Expression of the gibbon ape leukemia virus receptor-1 in rhesus macaque tissues. J Med Primatol. 1997;26:59-62 pubmed
    A cDNA fragment specific for the rhesus macaque gibbon ape leukemia virus (GaLV) receptor (Glvr-1) was isolated by polymerase chain reaction (PCR) amplification and oligonucleotide primers specific for human Glvr-1 and a cDNA library ..
  43. Mascarenhas L, Stripecke R, Case S, Xu D, Weinberg K, Kohn D. Gene delivery to human B-precursor acute lymphoblastic leukemia cells. Blood. 1998;92:3537-45 pubmed
    ..Both vectors transduced the primary B-precursor ALL cells with high efficiencies. These studies may be applied for investigating gene delivery into primary human B-precursor ALL cells to be used for immunotherapy...
  44. Wilson C, Farrell K, Eiden M. Comparison of cDNAs encoding the gibbon ape leukaemia virus receptor from susceptible and non-susceptible murine cells. J Gen Virol. 1994;75 ( Pt 8):1901-8 pubmed
    ..m. musculus and M. dunni proteins, but similar to that of the functional human GaLV receptor. These results confirm the importance of the amino acids of this region in GaLV receptor function...
  45. Lin E, Salon C, Brambilla E, Lavillette D, Szecsi J, Cosset F, et al. Fusogenic membrane glycoproteins induce syncytia formation and death in vitro and in vivo: a potential therapy agent for lung cancer. Cancer Gene Ther. 2010;17:256-65 pubmed publisher
    ..In this report, plasmids encoding for FMGs from Human Endogenous Retrovirus-W (HERV-W) was compared with Gibbon Ape Leukemia Virus (GALV) and feline endogenous virus RD-114 (RD)...
  46. Chaudry G, Eiden M. Mutational analysis of the proposed gibbon ape leukemia virus binding site in Pit1 suggests that other regions are important for infection. J Virol. 1997;71:8078-81 pubmed
    ..residues 550 to 558 in domain IV) and related receptors has remained the only sequence implicated in gibbon ape leukemia virus (GALV) infection, and an acidic residue at the first position appeared indispensable...
  47. Jensen T, Sullivan D, Morgan R, Taichman L, Nussenblatt R, Blaese R, et al. Retrovirus-mediated gene transfer of ornithine-delta-aminotransferase into keratinocytes from gyrate atrophy patients. Hum Gene Ther. 1997;8:2125-32 pubmed
    ..Ornithine catabolism was maintained at high levels when the transduced patient keratinocytes were differentiated in vitro as a multilayered cutaneous organoid...
  48. Logg C, Baranick B, Lemp N, Kasahara N. Adaptive evolution of a tagged chimeric gammaretrovirus: identification of novel cis-acting elements that modulate splicing. J Mol Biol. 2007;369:1214-29 pubmed
    ..such tagged MLV expressing green fluorescent protein, we replaced the native env sequence with that of gibbon ape leukemia virus (GALV)...
  49. Relander T, Johansson M, Olsson K, Ikeda Y, Takeuchi Y, Collins M, et al. Gene transfer to repopulating human CD34+ cells using amphotropic-, GALV-, or RD114-pseudotyped HIV-1-based vectors from stable producer cells. Mol Ther. 2005;11:452-9 pubmed
    ..three different gammaretrovirus envelopes were used: the amphotropic MLV envelope (MLV-A), a modified gibbon ape leukemia virus envelope (GALV+), and a modified feline endogenous virus RD114 envelope (RDpro)...
  50. Clémenceau B, Gallot G, Lemoine F, Klatzmann D, Vié H. Preparation of genetically homogeneous antigen-specific thymidine kinase positive T-lymphocyte clones for the control of alloreactivity post-bone marrow transplantation. Hum Gene Ther. 2004;15:542-52 pubmed
    ..Transductions were carried out using gibbon ape leukemia virus (GALV)-pseudotyped retroviral particles harboring a bicistronic Thy-1/TK vector produced by TEFLY GA16-..
  51. Goerner M, Horn P, Peterson L, Kurre P, Storb R, Rasko J, et al. Sustained multilineage gene persistence and expression in dogs transplanted with CD34(+) marrow cells transduced by RD114-pseudotype oncoretrovirus vectors. Blood. 2001;98:2065-70 pubmed
    ..with vectors produced by the RD114-pseudotype packaging cells FLYRD (LgGLSN and LNX) or by the gibbon ape leukemia virus (GALV)-pseudotype packaging cells PG13 (LNY). A total of 5 dogs were studied...
  52. Movassagh M, Boyer O, Burland M, Leclercq V, Klatzmann D, Lemoine F. Retrovirus-mediated gene transfer into T cells: 95% transduction efficiency without further in vitro selection. Hum Gene Ther. 2000;11:1189-200 pubmed
  53. Turatti F, Figini M, Alberti P, Willemsen R, Canevari S, Mezzanzanica D. Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor. J Gene Med. 2005;7:158-70 pubmed
    ..However, clinical application of the strategy has been hampered by the potential side effects associated with immunogenicity and by low transduction efficiency...
  54. Bunnell B, Kluge K, Lee Lin S, Byrne E, Orlic D, Metzger M, et al. Transplantation of transduced nonhuman primate CD34+ cells using a gibbon ape leukemia virus vector: restricted expression of the gibbon ape leukemia virus receptor to a subset of CD34+ cells. Gene Ther. 1999;6:48-56 pubmed
    ..Moloney murine leukemia virus (MLV) retroviral vector and a retroviral vector derived from the gibbon ape leukemia virus (GaLV) packaging cell line, PG13...
  55. Beard B, Mezquita P, Morris J, Kiem H. Efficient transduction and engraftment of G-CSF-mobilized peripheral blood CD34+ cells in nonhuman primates using GALV-pseudotyped gammaretroviral vectors. Mol Ther. 2006;14:212-7 pubmed
    ..These findings demonstrate that high stem cell gene transfer levels can be achieved using G-CSF-mobilized PBSC with Phoenix-GALV-pseudotyped vectors...
  56. Sabatino D, Do B, Pyle L, Seidel N, Girard L, Spratt S, et al. Amphotropic or gibbon ape leukemia virus retrovirus binding and transduction correlates with the level of receptor mRNA in human hematopoietic cell lines. Blood Cells Mol Dis. 1997;23:422-33 pubmed
    ..In this study we compared the level of PiT-2 and PiT-1, the Gibbon Ape Leukemia Virus receptor (GaLV), in 5 human tissue culture cell lines...
  57. Carrondo M, Merten O, Haury M, Alves P, Coroadinha A. Impact of retroviral vector components stoichiometry on packaging cell lines: effects on productivity and vector quality. Hum Gene Ther. 2008;19:199-210 pubmed
    ..Thus, stoichiometric optimization of viral components not only improves cell productivity but also increases vector quality...
  58. Brade A, Szmitko P, Ngo D, Liu F, Klamut H. Heat-directed tumor cell fusion. Hum Gene Ther. 2003;14:447-61 pubmed
    ..Here we describe heat-directed targeting of an activated form of the Gibbon ape leukemia virus env protein (GALV FMG) to tumor cells...
  59. Price D, Lin S, Han Z, Simpson G, Coffin R, Wong J, et al. Oncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2010;136:151-8 pubmed publisher
    ..To determine if prodrug conversion of fluorocytosine to fluorouracil by an engineered herpes virus, OncoVEX(GALV/CD), enhances oncolytic therapy of head and neck squamous cell carcinoma...
  60. Relander T, Brun A, Olsson K, Pedersen L, Richter J. Overexpression of gibbon ape leukemia virus (GALV) receptor (GLVR1) on human CD34(+) cells increases gene transfer mediated by GALV pseudotyped vectors. Mol Ther. 2002;6:400-6 pubmed
    Retroviral transduction of CD34(+) cells on Retronectin using gibbon ape leukemia virus (GALV) pseudotyped vectors is inhibited by high concentrations of vector containing medium (VCM)...
  61. Kurre P, Morris J, Miller A, Kiem H. Envelope fusion protein binding studies in an inducible model of retrovirus receptor expression and in CD34(+) cells emphasize limited transduction at low receptor levels. Gene Ther. 2001;8:593-9 pubmed
    ..present study we investigated the impact of receptor expression level on transduction by a vector with a gibbon ape leukemia virus (GALV) envelope protein in a tetracycline-inducible tissue culture model that allowed for the cell cycle-..
  62. Josephson N, Sabo K, Abkowitz J. Transduction of feline hematopoietic cells by oncoretroviral vectors pseudotyped with the subgroup A feline leukemia virus (FeLV-A). Mol Ther. 2000;2:56-62 pubmed
    ..by oncoretroviral vectors pseudotyped with the subgroup A feline leukemia virus (FeLV-A), the gibbon ape leukemia virus (GALV), and the murine amphotropic virus...
  63. Orchard P, Blazar B, Burger S, Levine B, Basso L, Nelson D, et al. Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor. Hum Gene Ther. 2002;13:979-88 pubmed
    ..3% vs. 23.5%). We conclude that a strategy based on activation of human T cells with anti-CD3/CD28 beads can result in sufficient transduction, expansion, and purification based on NGFR expression for clinical trials...
  64. Kondo E, Topp M, Kiem H, Obata Y, Morishima Y, Kuzushima K, et al. Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells. J Immunol. 2002;169:2164-71 pubmed
    ..ELISPOT assays revealed that the CTL lines used multiple HLA alleles as restricting elements. Thus, CD40-B cells transduced retrovirally with Ag-encoding cDNA can be potent APC and facilitate to generate Ag-specific CTL in vitro...
  65. Masuda M, Hanson C, Hoffman P, Ruscetti S. Analysis of the unique hamster cell tropism of ecotropic murine leukemia virus PVC-211. J Virol. 1996;70:8534-9 pubmed
    ..Further studies on the interaction between PVC-211 MuLV and the receptor on hamster cells may provide novel insights into the molecular mechanisms for receptor recognition and binding by viral envelope glycoproteins...
  66. Eglitis M, Schneiderman R. Transduction of human hematopoietic progenitor cells with retroviral vectors based on the gibbon ape leukemia virus. Biochem Biophys Res Commun. 1997;231:477-80 pubmed
    ..We have examined the capacity of newly described retroviral vectors based on the gibbon ape leukemia virus (GaLV) to introduce genes into human hematopoietic progenitor cells...
  67. Ghani K, Wang X, de Campos Lima P, Olszewska M, Kamen A, Riviere I, et al. Efficient human hematopoietic cell transduction using RD114- and GALV-pseudotyped retroviral vectors produced in suspension and serum-free media. Hum Gene Ther. 2009;20:966-74 pubmed publisher
    ..These cell lines grow in suspension and SFM, and produce high-titer RD114- and gibbon ape leukemia virus (GALV)-pseudotyped vectors for a 3-month culture period...
  68. Higuchi H, Bronk S, Bateman A, Harrington K, Vile R, Gores G. Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapy. Cancer Res. 2000;60:6396-402 pubmed
    ..Transfection of Hep3B cells with the Gibbon Ape leukemia virus hyperfusogenic envelope protein (GALV-FMG) resulted in the formation of multinucleated syncytia that ..
  69. Tan L, Jia H, Liu R, Wu J, Han H, Zuo Y, et al. Inhibition of NF-kappaB in fusogenic membrane glycoprotein causing HL-60 cell death: implications for acute myeloid leukemia. Cancer Lett. 2009;273:114-21 pubmed publisher
    ..Here, we showed overexpression of HSP70 in HL-60 cells mediated by Gibbon Ape leukemia virus hyperfusogenic envelope protein (GALV-FMG) inhibited the nuclear translocation of p65, the transcriptive ..
  70. Barquinero J, Segovia J, Ramirez M, Limon A, Guenechea G, Puig T, et al. Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice. Blood. 2000;95:3085-93 pubmed
    ..Samples were prestimulated on Retronectin-coated dishes and infected with gibbon ape leukemia virus (GALV)-pseudotyped FMEV vectors encoding the enhanced green fluorescent protein (EGFP)...
  71. Fielding A, Chapel Fernandes S, Chadwick M, Bullough F, Cosset F, Russell S. A hyperfusogenic gibbon ape leukemia envelope glycoprotein: targeting of a cytotoxic gene by ligand display. Hum Gene Ther. 2000;11:817-26 pubmed