feline leukemia virus

Summary

Summary: A species of GAMMARETROVIRUS causing leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats. Several cellular oncogenes confer on FeLV the ability to induce sarcomas (see also SARCOMA VIRUSES, FELINE).

Top Publications

  1. Danner R, Goltz D, Hess S, Banko P. Evidence of feline immunodeficiency virus, feline leukemia virus, and Toxoplasma gondii in feral cats on Mauna Kea, Hawaii. J Wildl Dis. 2007;43:315-8 pubmed
    We determined prevalence to feline immunodeficiency virus (FIV) antibodies, feline leukemia virus (FeLV) antigen, and Toxoplasma gondii antibodies in feral cats (Felis catus) on Mauna Kea Hawaii from April 2002 to May 2004. Six of 68 (8...
  2. Stützer B, Muller F, Majzoub M, Lutz H, Greene C, Hermanns W, et al. Role of latent feline leukemia virus infection in nonregenerative cytopenias of cats. J Vet Intern Med. 2010;24:192-7 pubmed publisher
    Nonregenerative cytopenias such as nonregenerative anemia, neutropenia, and thrombocytopenia in cats with feline leukemia virus (FeLV) antigen are assumed to be caused by the underlying FeLV infection...
  3. Wardini A, Guimarães Costa A, Nascimento M, Nadaes N, Danelli M, Mazur C, et al. Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus. J Gen Virol. 2010;91:259-64 pubmed publisher
    b>Feline leukemia virus (FeLV), a common, naturally occurring gammaretrovirus in domestic cats, is associated with degenerative diseases of the haematopoietic system, immunodeficiency and neoplasia...
  4. Gleich S, Hartmann K. Hematology and serum biochemistry of feline immunodeficiency virus-infected and feline leukemia virus-infected cats. J Vet Intern Med. 2009;23:552-8 pubmed publisher
    Hematological and biochemical values in cats naturally infected by feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV) are not completely documented.
  5. Dubey J, Lappin M, Kwok O, Mofya S, Chikweto A, Baffa A, et al. Seroprevalence of Toxoplasma gondii and concurrent Bartonella spp., feline immunodeficiency virus, and feline leukemia virus infections in cats from Grenada, West Indies. J Parasitol. 2009;95:1129-33 pubmed publisher
    ..are zoonotic pathogens of cats. Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLv) are related to human immunodeficiency virus, and human leukemia virus, respectively; all of these ..
  6. Torres A, O Halloran K, Larson L, Schultz R, Hoover E. Feline leukemia virus immunity induced by whole inactivated virus vaccination. Vet Immunol Immunopathol. 2010;134:122-31 pubmed publisher
    A fraction of cats exposed to feline leukemia virus (FeLV) effectively contain virus and resist persistent antigenemia/viremia...
  7. Fujino Y, Liao C, Zhao Y, Pan J, Mathes L, Hayes K, et al. Identification of a novel common proviral integration site, flit-1, in feline leukemia virus induced thymic lymphoma. Virology. 2009;386:16-22 pubmed publisher
    A new proviral integration site for feline leukemia virus (FeLV), termed flit-1, was identified from feline thymic lymphoma...
  8. Hofmann Lehmann R, Cattori V, Tandon R, Boretti F, Meli M, Riond B, et al. How molecular methods change our views of FeLV infection and vaccination. Vet Immunol Immunopathol. 2008;123:119-23 pubmed publisher
    ..The use of sensitive molecular methods will contribute to a more in-depth understanding of the FeLV pathogenesis...
  9. Torres A, O Halloran K, Larson L, Schultz R, Hoover E. Development and application of a quantitative real-time PCR assay to detect feline leukemia virus RNA. Vet Immunol Immunopathol. 2008;123:81-9 pubmed publisher
    We previously defined four categories of feline leukemia virus (FeLV) infection, designated as abortive, regressive, latent, and progressive...

More Information

Publications79

  1. Chen H, Bechtel M, Shi Y, Phipps A, Mathes L, Hayes K, et al. Pathogenicity induced by feline leukemia virus, Rickard strain, subgroup A plasmid DNA (pFRA). J Virol. 1998;72:7048-56 pubmed
    A new provirus clone of feline leukemia virus (FeLV), which we named FeLV-A (Rickard) or FRA, was characterized with respect to viral interference group, host range, complete genome sequence, and in vivo pathogenicity in specific-..
  2. Tandon R, Cattori V, Willi B, Lutz H, Hofmann Lehmann R. Quantification of endogenous and exogenous feline leukemia virus sequences by real-time PCR assays. Vet Immunol Immunopathol. 2008;123:129-33 pubmed publisher
    ..In the genome of all domestic cats, sequences closely related to exogenous FeLV known as endogenous feline leukemia virus (enFeLV), are present. enFeLV are incapable of giving rise to infectious virus particles...
  3. Vobis M, D Haese J, Mehlhorn H, Mencke N. Evidence of horizontal transmission of feline leukemia virus by the cat flea ( Ctenocephalides felis). Parasitol Res. 2003;91:467-70 pubmed
    The feline leukemia virus (FeLV) is a naturally occurring and widespread retrovirus among domestic cats. The virus is mainly transmitted horizontally through saliva, blood and other body fluids by close contact between cats...
  4. Lutz H, Lehmann R, Winkler G, Kottwitz B, Dittmer A, Wolfensberger C, et al. [Feline immunodeficiency virus in Switzerland: clinical aspects and epidemiology in comparison with feline leukemia virus and coronaviruses]. Schweiz Arch Tierheilkd. 1990;132:217-25 pubmed
    ..It was concluded that based on the clinical symptoms alone FIV-infection could not be diagnosed nor differentiated from the other 2 infections. ..
  5. Nishigaki K, Hanson C, Thompson D, Yugawa T, Hisasue M, Tsujimoto H, et al. Analysis of the disease potential of a recombinant retrovirus containing Friend murine leukemia virus sequences and a unique long terminal repeat from feline leukemia virus. J Virol. 2002;76:1527-32 pubmed
    We have molecularly cloned a feline leukemia virus (FeLV) (clone 33) from a domestic cat with acute myeloid leukemia (AML)...
  6. Endo Y, Uema M, Miura R, Tsukiyama Kohara K, Tsujimoto H, Yoneda K, et al. Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions (Panthera leo) in Japan. J Vet Med Sci. 2004;66:1587-9 pubmed
    Sero-prevalences of canine distemper virus (CDV), feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) were evaluated in 20 captive lions in two Japanese zoos. Anti-CDV antibody was detected in 13 of 20 lions...
  7. Abujamra A, Faller D, Ghosh S. Mutations that abrogate transactivational activity of the feline leukemia virus long terminal repeat do not affect virus replication. Virology. 2003;309:294-305 pubmed
  8. Levy L. Advances in understanding molecular determinants in FeLV pathology. Vet Immunol Immunopathol. 2008;123:14-22 pubmed publisher
    b>Feline leukemia virus (FeLV) occurs in nature not as a single genomic species but as a family of closely related viruses...
  9. Torres A, Mathiason C, Hoover E. Re-examination of feline leukemia virus: host relationships using real-time PCR. Virology. 2005;332:272-83 pubmed
    ..ineffective viral containment are central to immunoprevention and therapies of retroviral infections. Feline leukemia virus (FeLV) infection is unique as a naturally occurring, diametric example of effective vs...
  10. Coelho F, Bomfim M, de Andrade Caxito F, Ribeiro N, Luppi M, Costa E, et al. Naturally occurring feline leukemia virus subgroup A and B infections in urban domestic cats. J Gen Virol. 2008;89:2799-805 pubmed publisher
    A nested-PCR (n-PCR) was used to detect feline leukemia virus (FeLV) proviral DNA in blood samples from 464 sick and 608 healthy domestic cats (Felis catus) selected by convenience, and a significantly high prevalence of FeLV infection ..
  11. Fujino Y, Ohno K, Tsujimoto H. Molecular pathogenesis of feline leukemia virus-induced malignancies: insertional mutagenesis. Vet Immunol Immunopathol. 2008;123:138-43 pubmed publisher
    b>Feline leukemia virus (FeLV), which is subclassified into three subgroups of A, B and C, is a pathogenic retrovirus in cats...
  12. Cunningham M, Brown M, Shindle D, Terrell S, Hayes K, Ferree B, et al. Epizootiology and management of feline leukemia virus in the Florida puma. J Wildl Dis. 2008;44:537-52 pubmed
    b>Feline leukemia virus (FeLV) was not detected in Florida pumas (Puma concolor coryi) in almost 20 yr of surveillance; however, the finding of two FeLV antigen-positive pumas during the 2002-2003 capture season led to an investigation of ..
  13. Hofmann Lehmann R, Fehr D, Grob M, Elgizoli M, Packer C, Martenson J, et al. Prevalence of antibodies to feline parvovirus, calicivirus, herpesvirus, coronavirus, and immunodeficiency virus and of feline leukemia virus antigen and the interrelationship of these viral infections in free-ranging lions in east Africa. Clin Diagn Lab Immunol. 1996;3:554-62 pubmed
    ..FCV), herpesvirus (FHV), coronavirus (FCoV), parvovirus (FPV), and immunodeficiency virus (FIV) and of feline leukemia virus (FeLV) antigen in 311 serum samples collected between 1984 and 1991 from lions inhabiting Tanzania's ..
  14. Flynn J, Dunham S, Watson V, Jarrett O. Longitudinal analysis of feline leukemia virus-specific cytotoxic T lymphocytes: correlation with recovery from infection. J Virol. 2002;76:2306-15 pubmed
    b>Feline leukemia virus (FeLV) is a common naturally occurring gammaretrovirus of domestic cats that is associated with degenerative diseases of the hematopoietic system, immunodeficiency, and neoplasia...
  15. Shalev Z, Duffy S, Adema K, Prasad R, Hussain N, Willett B, et al. Identification of a feline leukemia virus variant that can use THTR1, FLVCR1, and FLVCR2 for infection. J Virol. 2009;83:6706-16 pubmed publisher
    The pathogenic subgroup C feline leukemia virus (FeLV-C) arises in infected cats as a result of mutations in the envelope (Env) of the subgroup A FeLV (FeLV-A)...
  16. Hisasue M, Nagashima N, Nishigaki K, Fukuzawa I, Ura S, Katae H, et al. Myelodysplastic syndromes and acute myeloid leukemia in cats infected with feline leukemia virus clone33 containing a unique long terminal repeat. Int J Cancer. 2009;124:1133-41 pubmed publisher
    b>Feline leukemia virus (FeLV) clone33 was obtained from a domestic cat with acute myeloid leukemia (AML)...
  17. de Mari K, Maynard L, Sanquer A, Lebreux B, Eun H. Therapeutic effects of recombinant feline interferon-omega on feline leukemia virus (FeLV)-infected and FeLV/feline immunodeficiency virus (FIV)-coinfected symptomatic cats. J Vet Intern Med. 2004;18:477-82 pubmed
    ..rFeIFN-omega, was evaluated for the treatment of cats presented with clinical signs associated with feline leukemia virus (FeLV) infection and FeLV/feline immunodeficiency virus (FIV) coinfection in the field...
  18. Brown J, Fung C, Tailor C. Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1. J Virol. 2006;80:1742-51 pubmed
    Infection of cells by the highly anemogenic feline leukemia virus subgroup C (FeLV-C) is mediated by the heme exporter FLVCR1, a cell surface protein containing 12 potential transmembrane segments with six presumptive extracellular loops ..
  19. Gomes Keller M, Gönczi E, Tandon R, Riondato F, Hofmann Lehmann R, Meli M, et al. Detection of feline leukemia virus RNA in saliva from naturally infected cats and correlation of PCR results with those of current diagnostic methods. J Clin Microbiol. 2006;44:916-22 pubmed
    A novel diagnostic test for feline leukemia virus (FeLV) RNA in saliva from naturally infected cats is described in this study...
  20. Quimby J, Elston T, Hawley J, Brewer M, Miller A, Lappin M. Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. J Feline Med Surg. 2008;10:66-72 pubmed
    ..Serum was tested for feline leukemia virus (FeLV) antigen and antibodies against feline immunodeficiency virus, feline calicivirus (FCV), feline ..
  21. Chandhasin C, Lobelle Rich P, Levy L. Feline leukaemia virus LTR variation and disease association in a geographical and temporal cluster. J Gen Virol. 2004;85:2937-42 pubmed
    ..While the length and termini of enhancer duplications were variable, the 21 bp repeat unit was invariant. Triplication of the 21 bp repeat conferred the optimal replicative advantage in feline cells...
  22. Meli M, Cattori V, Martínez F, López G, Vargas A, Simón M, et al. Feline leukemia virus and other pathogens as important threats to the survival of the critically endangered Iberian lynx (Lynx pardinus). PLoS ONE. 2009;4:e4744 pubmed publisher
    ..Fourteen lynxes were feline leukemia virus (FeLV) provirus-positive; eleven of these were antigenemic (FeLV p27 positive)...
  23. Lee I, Levy J, Gorman S, Crawford P, Slater M. Prevalence of feline leukemia virus infection and serum antibodies against feline immunodeficiency virus in unowned free-roaming cats. J Am Vet Med Assoc. 2002;220:620-2 pubmed
    ..To determine prevalence of FeLV infection and serum antibodies against feline immunodeficiency virus (FIV) in unowned free-roaming cats...
  24. Buchmann A, Kershaw O, Kempf V, Gruber A. Does a feline leukemia virus infection pave the way for Bartonella henselae infection in cats?. J Clin Microbiol. 2010;48:3295-300 pubmed publisher
    ..was to investigate the influence of the most important viruses known to cause immunosuppression in cats-Feline leukemia virus (FeLV), Feline immunodeficiency virus (FIV), and Feline panleukopenia virus (FPV)-on natural B...
  25. Hofmann Lehmann R, Holznagel E, Ossent P, Lutz H. Parameters of disease progression in long-term experimental feline retrovirus (feline immunodeficiency virus and feline leukemia virus) infections: hematology, clinical chemistry, and lymphocyte subsets. Clin Diagn Lab Immunol. 1997;4:33-42 pubmed
    After several years of latency, feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) cause fatal disease in the cat...
  26. Tailor C, Kabat D. Variable regions A and B in the envelope glycoproteins of feline leukemia virus subgroup B and amphotropic murine leukemia virus interact with discrete receptor domains. J Virol. 1997;71:9383-91 pubmed
    The surface (SU) envelope glycoproteins of feline leukemia virus subgroup B (FeLV-B) and amphotropic murine leukemia virus (A-MLV) are highly related, even in the variable regions VRA and VRB that have been shown to be required for ..
  27. Takeuchi Y, Vile R, Simpson G, O HARA B, Collins M, Weiss R. Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. J Virol. 1992;66:1219-22 pubmed
    Pseudotypes of gibbon ape leukemia virus/simian sarcoma-associated virus (GALV/SSAV) and feline leukemia virus subgroup B (FeLV-B) have been constructed by rescuing a Moloney murine leukemia virus vector genome with wild-type GALV/SSAV ..
  28. Métais J, Topp S, Doty R, Borate B, Nguyen A, Wolfsberg T, et al. Feline leukemia virus integrase and capsid packaging functions do not change the insertion profile of standard Moloney retroviral vectors. Gene Ther. 2010;17:799-804 pubmed publisher
    ..Recently, we developed a producer cell line called CatPac that packages standard MoMLV vectors with feline leukemia virus (FeLV) gag, pol and env gene products...
  29. Tailor C, Willett B, Kabat D. A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. J Virol. 1999;73:6500-5 pubmed
    Domestic cats infected with the horizontally transmitted feline leukemia virus subgroup A (FeLV-A) often produce mutants (termed FeLV-C) that bind to a distinct cell surface receptor and cause severe aplastic anemia in vivo and ..
  30. Cheng H, Anderson M, Overbaugh J. Feline leukemia virus T entry is dependent on both expression levels and specific interactions between cofactor and receptor. Virology. 2007;359:170-8 pubmed
    b>Feline leukemia virus (FeLV) subgroup T uses both a multiple membrane-spanning receptor, FePit1, and a soluble cofactor, FeLIX, to enter feline cells...
  31. Hofmann Lehmann R, Tandon R, Boretti F, Meli M, Willi B, Cattori V, et al. Reassessment of feline leukaemia virus (FeLV) vaccines with novel sensitive molecular assays. Vaccine. 2006;24:1087-94 pubmed
    ..The loads were significantly associated with the infection outcome. Thus, commonly used FeLV vaccines understood to be successful model antiretroviral vaccines protecting against FeLV-related diseases do not confer sterilizing immunity...
  32. Little S, Sears W, Lachtara J, Bienzle D. Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in Canada. Can Vet J. 2009;50:644-8 pubmed
    The purposes of this study were to determine the seroprevalence of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) infection among cats in Canada and to identify risk factors for seropositivity...
  33. Miyazawa T. Infections of feline leukemia virus and feline immunodeficiency virus. Front Biosci. 2002;7:d504-18 pubmed
    ..Two retroviruses, feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV), have been recognized as causative agents of a variety of ..
  34. Mazari P, Linder Basso D, Sarangi A, Chang Y, Roth M. Single-round selection yields a unique retroviral envelope utilizing GPR172A as its host receptor. Proc Natl Acad Sci U S A. 2009;106:5848-53 pubmed publisher
    ..The 11-aa targeting domain of the modified feline leukemia virus envelope consists of a constrained peptide...
  35. Rey M, Prasad R, Tailor C. The C domain in the surface envelope glycoprotein of subgroup C feline leukemia virus is a second receptor-binding domain. Virology. 2008;370:273-84 pubmed
    ..In this study, we show that the Cdom region in the SU from subgroup C feline leukemia virus (FeLV-C) forms a second receptor-binding domain that is distinct from its RBD, and which can independently ..
  36. Sarangi A, Bupp K, Roth M. Identification of a retroviral receptor used by an envelope protein derived by peptide library screening. Proc Natl Acad Sci U S A. 2007;104:11032-7 pubmed publisher
    ..We screened a random peptide library within the receptor-binding domain of a feline leukemia virus retroviral Envelope (FeLV Env) protein for productive infection of feline AH927 cells...
  37. Cattori V, Tandon R, Pepin A, Lutz H, Hofmann Lehmann R. Rapid detection of feline leukemia virus provirus integration into feline genomic DNA. Mol Cell Probes. 2006;20:172-81 pubmed
    b>Feline leukemia virus (FeLV) is a gamma retrovirus that induces fatal diseases in domestic cats...
  38. Gomes Keller M, Tandon R, Gönczi E, Meli M, Hofmann Lehmann R, Lutz H. Shedding of feline leukemia virus RNA in saliva is a consistent feature in viremic cats. Vet Microbiol. 2006;112:11-21 pubmed
    The purpose of this investigation was to characterize the shedding pattern of feline leukemia virus (FeLV) RNA in saliva, and to correlate it with the proviral load in whole blood, viral load in plasma, levels of p27 in saliva and plasma,..
  39. Levy J, Crawford C, Hartmann K, Hofmann Lehmann R, Little S, Sundahl E, et al. 2008 American Association of Feline Practitioners' feline retrovirus management guidelines. J Feline Med Surg. 2008;10:300-16 pubmed publisher
    b>Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are among the most common infectious diseases of cats...
  40. Kipar A, Kremendahl J, Grant C, von Bothmer I, Reinacher M. Expression of viral proteins in feline leukemia virus-associated enteritis. Vet Pathol. 2000;37:129-36 pubmed
    Fourteen cases of feline leukemia virus (FeLV)-associated enteritis were immunohistologically examined for the expression of FeLV proteins gp70, p27, and p15E in the jejunum, mesenteric lymph nodes, spleen, and bone marrow...
  41. Tandon R, Cattori V, Pepin A, Riond B, Meli M, McDonald M, et al. Association between endogenous feline leukemia virus loads and exogenous feline leukemia virus infection in domestic cats. Virus Res. 2008;135:136-43 pubmed publisher
    Recently, we demonstrated that endogenous feline leukemia virus (enFeLV) loads may vary among cats of different populations and that FeLV-infected cats have higher enFeLV loads than uninfected cats...
  42. Pan J, Al Dubaib M, Liao C, Fujino Y, Hinton D, Hayes K, et al. In vivo expression of GFP transgene delivered via a replicating feline leukemia virus. Vet Microbiol. 2005;110:181-95 pubmed
    We previously described replication-competent feline leukemia virus (FeLV) vectors with high-level and stable expression of a green fluorescent protein (GFP) or a suicide transgene in cell cultures in vitro...
  43. Quigley J, Burns C, Anderson M, Lynch E, Sabo K, Overbaugh J, et al. Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. Blood. 2000;95:1093-9 pubmed
    b>Feline leukemia virus-C (FeLV-C) causes red cell aplasia in cats, likely through its interaction with its cell surface receptor...
  44. Bupp K, Sarangi A, Roth M. Probing sequence variation in the receptor-targeting domain of feline leukemia virus envelope proteins with peptide display libraries. J Virol. 2005;79:1463-9 pubmed
    ..and receptor targeting lie within a short peptide in the Vr1 region of the envelope (Env) proteins of feline leukemia virus (FeLV) subgroups A and C...
  45. Luaces I, Domenech A, Garcia Montijano M, Collado V, Sanchez C, Tejerizo J, et al. Detection of Feline leukemia virus in the endangered Iberian lynx (Lynx pardinus). J Vet Diagn Invest. 2008;20:381-5 pubmed
    ..Six samples were positive for Feline leukemia virus (FeLV), but no samples tested positive for Feline immunodeficiency virus...
  46. Chandhasin C, Coan P, Levy L. Subtle mutational changes in the SU protein of a natural feline leukemia virus subgroup A isolate alter disease spectrum. J Virol. 2005;79:1351-60 pubmed
    FeLV-945 is a representative isolate of the natural feline leukemia virus (FeLV) variant predominant in non-T-cell malignant, proliferative, and degenerative diseases in a geographic cohort...
  47. Cattori V, Hofmann Lehmann R. Absolute quantitation of feline leukemia virus proviral DNA and viral RNA loads by TaqMan real-time PCR and RT-PCR. Methods Mol Biol. 2008;429:73-87 pubmed publisher
    ..chain reaction (PCR)-based methods have been developed recently for the detection and quantitation of feline leukemia virus (FeLV) proviral DNA in infected cats...
  48. Goldkamp C, Levy J, Edinboro C, Lachtara J. Seroprevalences of feline leukemia virus and feline immunodeficiency virus in cats with abscesses or bite wounds and rate of veterinarian compliance with current guidelines for retrovirus testing. J Am Vet Med Assoc. 2008;232:1152-8 pubmed publisher
  49. Polani S, Roca A, Rosensteel B, Kolokotronis S, Bar Gal G. Evolutionary dynamics of endogenous feline leukemia virus proliferation among species of the domestic cat lineage. Virology. 2010;405:397-407 pubmed publisher
    ..Comparison of wildcat and domestic cat enFeLVs indicated that a distinctive germ line invasion of enFeLVs has not occurred since the cat was domesticated...
  50. Shojima T, Nakata R, Miyazawa T. Host cell range of T-lymphotropic feline leukemia virus in vitro. Biochem Biophys Res Commun. 2006;345:1466-70 pubmed
    We compared the host cell range of T-lymphotropic feline leukemia virus (FeLV-T) with that of FeLV subgroup B (FeLV-B) by pseudotype assay in the presence of FeLIX, a truncated envelope glycoprotein of endogenous FeLV...
  51. Tailor C, Takeuchi Y, O HARA B, Johann S, Weiss R, Collins M. Mutation of amino acids within the gibbon ape leukemia virus (GALV) receptor differentially affects feline leukemia virus subgroup B, simian sarcoma-associated virus, and GALV infections. J Virol. 1993;67:6737-41 pubmed
    ..The three type C retroviruses, gibbon ape leukemia virus (GALV), simian sarcoma-associated virus (SSAV), and feline leukemia virus subgroup B (FeLV-B), infect human cells by interacting with the same cell surface receptor, GLVR1...
  52. Levy J, Scott H, Lachtara J, Crawford P. Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity. J Am Vet Med Assoc. 2006;228:371-6 pubmed
    ..To determine seroprevalence of FeLV and FIV infection among cats in North America and risk factors for seropositivity...
  53. Tandon R, Cattori V, Gomes Keller M, Meli M, Golder M, Lutz H, et al. Quantitation of feline leukaemia virus viral and proviral loads by TaqMan real-time polymerase chain reaction. J Virol Methods. 2005;130:124-32 pubmed
    ..Thus, for most effective detection of FeLV exposure and characterization of the infection in a cat, PCR assays are recommended as diagnostic tools...
  54. Faix P, Feldman S, Overbaugh J, Eiden M. Host range and receptor binding properties of vectors bearing feline leukemia virus subgroup B envelopes can be modulated by envelope sequences outside of the receptor binding domain. J Virol. 2002;76:12369-75 pubmed
    To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes...
  55. Harbour D, Gunn Moore D, Gruffydd Jones T, Caney S, Bradshaw J, Jarrett O, et al. Protection against oronasal challenge with virulent feline leukaemia virus lasts for at least 12 months following a primary course of immunisation with Leukocell 2 vaccine. Vaccine. 2002;20:2866-72 pubmed
    The duration of immunity provided by a feline leukemia virus (FeLV) vaccine, Leukocell 2, was determined. Kittens were vaccinated when 9 and 12 weeks of age and were challenged 12 months later with FeLV-A/Glasgow-1...
  56. Lauring A, Cheng H, Eiden M, Overbaugh J. Genetic and biochemical analyses of receptor and cofactor determinants for T-cell-tropic feline leukemia virus infection. J Virol. 2002;76:8069-78 pubmed
    ..These data indicate that cofactor binding is not sufficient for FeLV-T infection and suggest that there may be a direct interaction between FeLV-T and the Pit1 receptor...
  57. Rodgers S, Baldwin C. A serologic survey of Oklahoma cats for antibodies to feline immunodeficiency virus, coronavirus, and Toxoplasma gondii and for antigen to feline leukemia virus. J Vet Diagn Invest. 1990;2:180-3 pubmed
    ..antibody test, and to Toxoplasma gondii by a commercial latex agglutination test and for the presence of feline leukemia virus antigen with one of 3 different commercial assay kits...
  58. Hartmann K, Block A, Ferk G, Beer B, Vollmar A, Lutz H. Treatment of feline leukemia virus (FeLV) infection. Vet Microbiol. 1999;69:111-3 pubmed
    ..Four placebo-controlled double-blind trials were performed to determine the therapeutic efficacy of Baypamun and other compounds in naturally FeLV-infected cats under controlled conditions...
  59. Overbaugh J, Bangham C. Selection forces and constraints on retroviral sequence variation. Science. 2001;292:1106-9 pubmed
    ..to specific lentiviruses [human and simian immunodeficiency viruses (HIV and SIV)] and oncoviruses [feline leukemia virus (FeLV) and human T cell leukemia virus (HTLV)] that differ in their extent of variation and in disease ..
  60. Hofmann Lehmann R, Huder J, Gruber S, Boretti F, Sigrist B, Lutz H. Feline leukaemia provirus load during the course of experimental infection and in naturally infected cats. J Gen Virol. 2001;82:1589-96 pubmed
    ..Detection of provirus carriers should contribute to further the control of FeLV. In addition, quantification of provirus loads will lead to a better understanding of FeLV pathogenesis and anti-retrovirus protective mechanisms...
  61. Finstad S, Prabhu S, Rulli K, Levy L. Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR. Virol J. 2004;1:3 pubmed
    b>Feline leukemia virus (FeLV) induces degenerative, proliferative and malignant hematologic disorders in its natural host, the domestic cat. FeLV-945 is a viral variant identified as predominant in a cohort of naturally infected animals...
  62. Grosenbaugh D, Leard T, Pardo M, Motes Kreimeyer L, Royston M. Comparison of the safety and efficacy of a recombinant feline leukemia virus (FeLV) vaccine delivered transdermally and an inactivated FeLV vaccine delivered subcutaneously. Vet Ther. 2004;5:258-62 pubmed
    ..No acute or persistent injection site reactions were observed. The rFeLV, delivered transdermally, provides protection against persistent FeLV antigenemia following a robust challenge that is equivalent to that of FeLV-k...
  63. Cattori V, Pepin A, Tandon R, Riond B, Meli M, Willi B, et al. Real-time PCR investigation of feline leukemia virus proviral and viral RNA loads in leukocyte subsets. Vet Immunol Immunopathol. 2008;123:124-8 pubmed publisher
    Cats exposed to feline leukemia virus (FeLV), a naturally occurring gammaretrovirus develop either progressive or regressive infection...
  64. Hanlon L, Argyle D, Bain D, Nicolson L, Dunham S, Golder M, et al. Feline leukemia virus DNA vaccine efficacy is enhanced by coadministration with interleukin-12 (IL-12) and IL-18 expression vectors. J Virol. 2001;75:8424-33 pubmed
    The expectation that cell-mediated immunity is important in the control of feline leukemia virus (FeLV) infection led us to test a DNA vaccine administered alone or with cytokines that favored the development of a Th1 immune response...
  65. Sugai J, Eiden M, Anderson M, Van Hoeven N, Meiering C, Overbaugh J. Identification of envelope determinants of feline leukemia virus subgroup B that permit infection and gene transfer to cells expressing human Pit1 or Pit2. J Virol. 2001;75:6841-9 pubmed
    ..The specific FeLV-Bs described here, which can enter cells using either human Pit receptor, may be useful as envelope pseudotypes for viruses used in gene therapy...
  66. Nakata R, Miyazawa T, Shin Y, Watanabe R, Mikami T, Matsuura Y. Reevaluation of host ranges of feline leukemia virus subgroups. Microbes Infect. 2003;5:947-50 pubmed
    We reevaluated the host ranges of feline leukemia virus (FeLV) subgroups A, B and C using pseudotype assays based on recombinant NB-tropic murine leukemia virus, which is not usually blocked after viral entry in mammalian cells...
  67. Johnson C, Lobelle Rich P, Puetter A, Levy L. Substitution of feline leukemia virus long terminal repeat sequences into murine leukemia virus alters the pattern of insertional activation and identifies new common insertion sites. J Virol. 2005;79:57-66 pubmed
    ..Finally, the findings demonstrate the utility of novel recombinant retroviruses such as MoFe2 to contribute new genes potentially relevant to the induction of lymphoid malignancy...
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    A compartmental model was built in order to study the circulation and impact of Feline Leukemia Virus (FeLV) in populations of domestic cats. The model was tested with data from a long-term study of several feline populations...
  69. Grosenbaugh D, Leard T, Pardo M. Protection from challenge following administration of a canarypox virus-vectored recombinant feline leukemia virus vaccine in cats previously vaccinated with a killed virus vaccine. J Am Vet Med Assoc. 2006;228:726-7 pubmed
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    Laboratory diagnosis of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) usually involves both viruses, as the clinical signs are similar and coinfection may occur...