gammaretrovirus

Summary

Summary: A genus of RETROVIRIDAE comprising endogenous sequences in mammals, related RETICULOENDOTHELIOSIS VIRUSES, AVIAN, and a reptilian virus. Many species contain oncogenes and cause leukemias and sarcomas.

Top Publications

  1. Cattoglio C, Facchini G, Sartori D, Antonelli A, Miccio A, Cassani B, et al. Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood. 2007;110:1770-8 pubmed
    ..The lower propensity of LV vectors for integrating in potentially dangerous regions of the human genome may be a factor determining a better safety profile for gene therapy applications...
  2. Beard B, Keyser K, Trobridge G, Peterson L, Miller D, Jacobs M, et al. Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus. Hum Gene Ther. 2007;18:423-34 pubmed
    ..location of 555 integration sites of the three most commonly used integrating retroviral vectors, that is, gammaretrovirus, lentivirus, and foamy virus, in long-term repopulating cells from dogs...
  3. Deichmann A, Hacein Bey Abina S, Schmidt M, Garrigue A, Brugman M, Hu J, et al. Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest. 2007;117:2225-32 pubmed
    ..Beyond the observed cases of insertional mutagenesis in 3 patients, these data help to elucidate the relationship between vector insertion and long-term in vivo selection of transduced cells in human patients with SCID-X1...
  4. Ribet D, Harper F, Esnault C, Pierron G, Heidmann T. The GLN family of murine endogenous retroviruses contains an element competent for infectious viral particle formation. J Virol. 2008;82:4413-9 pubmed publisher
    ..This family is in addition to the two MLV and mouse mammary tumor virus families of active mouse ERVs with an extracellular life cycle...
  5. Thornhill S, Schambach A, Howe S, Ulaganathan M, Grassman E, Williams D, et al. Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Mol Ther. 2008;16:590-8 pubmed publisher
  6. Stieler K, Schulz C, Lavanya M, Aepfelbacher M, Stocking C, Fischer N. Host range and cellular tropism of the human exogenous gammaretrovirus XMRV. Virology. 2010;399:23-30 pubmed publisher
    Recently, the first human infection with an exogenous gammaretrovirus (XMRV) was reported...
  7. Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer W, et al. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group. Science. 1999;285:1236-41 pubmed
    ..Persistent microchimerism (presence of donor cells in the recipient) was observed in 23 patients for up to 8.5 years...
  8. Yan Y, Liu Q, Kozak C. Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor. Retrovirology. 2009;6:87 pubmed publisher
    ..The mouse xenotropic/polytropic (X/PMV) gammaretroviruses rely on the XPR1 cell surface receptor for entry into host cells, and polymorphic variants of this receptor have been identified in different rodent species...
  9. Cui J, Tachedjian M, Wang L, Tachedjian G, Wang L, Zhang S. Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses. J Virol. 2012;86:4288-93 pubmed publisher
    ..In particular, phylogenetic analysis places Rhinolophus ferrumequinum retrovirus (RfRV), a new gammaretrovirus identified by de novo analysis of the Rhinolophus ferrumequinum transcriptome, and six other ..

More Information

Publications64

  1. Tarlinton R, Meers J, Young P. Biology and evolution of the endogenous koala retrovirus. Cell Mol Life Sci. 2008;65:3413-21 pubmed publisher
    ..Part of a multi-author review)...
  2. Switzer W, Jia H, Hohn O, Zheng H, Tang S, Shankar A, et al. Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States. Retrovirology. 2010;7:57 pubmed publisher
    ..Blinded PCR and serologic testing were performed at the US Centers for Disease Control and Prevention (CDC) and at two additional laboratories...
  3. Kim S, Kim N, Dong B, Boren D, Lee S, Das Gupta J, et al. Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer. J Virol. 2008;82:9964-77 pubmed publisher
    Xenotropic murine leukemia virus-related virus (XMRV) is a new human gammaretrovirus identified in prostate cancer tissue from patients homozygous for a reduced-activity variant of the antiviral enzyme RNase L...
  4. Oliveira N, Farrell K, Eiden M. In vitro characterization of a koala retrovirus. J Virol. 2006;80:3104-7 pubmed
    Recently, a new endogenous koala gammaretrovirus, designated KoRV, was isolated from koalas. The KoRV genome shares 78% nucleotide identity with another gammaretrovirus, gibbon ape leukemia virus (GALV)...
  5. Takeuchi Y, McClure M, Pizzato M. Identification of gammaretroviruses constitutively released from cell lines used for human immunodeficiency virus research. J Virol. 2008;82:12585-8 pubmed publisher
    ..and receptor usage studies, these contaminants were shown to be replication competent and to belong to the Gammaretrovirus genus...
  6. Fischer N, Hellwinkel O, Schulz C, Chun F, Huland H, Aepfelbacher M, et al. Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. J Clin Virol. 2008;43:277-83 pubmed publisher
    We previously identified a novel exogenous gammaretrovirus (xenotropic murine leukemia virus-related gammaretrovirus (XMRV)) using a pan-viral microarray. XMRV is the first MLV-related virus found in human infection...
  7. Yan Y, Liu Q, Wollenberg K, Martin C, Buckler White A, Kozak C. Evolution of functional and sequence variants of the mammalian XPR1 receptor for mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV. J Virol. 2010;84:11970-80 pubmed publisher
    ..for the mouse xenotropic or polytropic mouse leukemia viruses (X-MLVs or P-MLVs, respectively) of the gammaretrovirus family and for susceptibility to mouse-derived X/P-MLVs and to XMRV (xenotropic murine leukemia virus-related ..
  8. Kozak C. The mouse "xenotropic" gammaretroviruses and their XPR1 receptor. Retrovirology. 2010;7:101 pubmed publisher
  9. Denner J, Specke V, Thiesen U, Karlas A, Kurth R. Genetic alterations of the long terminal repeat of an ecotropic porcine endogenous retrovirus during passage in human cells. Virology. 2003;314:125-33 pubmed
    ..These data indicate that recombinant PERVs generated during infection of human cells can adapt and subsequently replicate with greater efficiency...
  10. Stieler K, Fischer N. Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV. PLoS ONE. 2010;5:e11738 pubmed publisher
    The human exogenous gammaretrovirus XMRV is thought to be implicated in prostate cancer and chronic fatigue syndrome...
  11. Shojima T, Hoshino S, Abe M, Yasuda J, Shogen H, Kobayashi T, et al. Construction and characterization of an infectious molecular clone of Koala retrovirus. J Virol. 2013;87:5081-8 pubmed publisher
    Koala retrovirus (KoRV) is a gammaretrovirus that is currently endogenizing into koalas. Studies on KoRV infection have been hampered by the lack of a replication-competent molecular clone...
  12. Paprotka T, Venkatachari N, Chaipan C, Burdick R, Delviks Frankenberry K, HU W, et al. Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs. J Virol. 2010;84:5719-29 pubmed publisher
    Xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus, has been isolated from human prostate cancer tissue and from activated CD4(+) T cells and B cells of patients with chronic fatigue syndrome, suggesting an ..
  13. Singh I, Gorzynski J, Drobysheva D, Bassit L, Schinazi R. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS ONE. 2010;5:e9948 pubmed publisher
    ..Both diseases affect a large fraction of the world population, with prostate cancer affecting one in six men, and CFS affecting an estimated 0.4 to 1% of the population...
  14. Silverman R, Nguyen C, Weight C, Klein E. The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome. Nat Rev Urol. 2010;7:392-402 pubmed publisher
    ..Emerging science surrounding XMRV is contributing to our knowledge of retroviral infections while focusing intense interest on two major human diseases...
  15. Cui J, Tachedjian G, Tachedjian M, Holmes E, Zhang S, Wang L. Identification of diverse groups of endogenous gammaretroviruses in mega- and microbats. J Gen Virol. 2012;93:2037-45 pubmed publisher
    ..Taken together, this study indicates that bats harbour distinct gammaretroviruses and may have played an important role as reservoir hosts during the diversification of mammalian gammaretroviruses...
  16. Paprotka T, Delviks Frankenberry K, Cingöz O, Martinez A, Kung H, Tepper C, et al. Recombinant origin of the retrovirus XMRV. Science. 2011;333:97-101 pubmed publisher
  17. Jeziorski E, Foulongne V, Ludwig C, Louhaem D, Chiocchia G, Segondy M, et al. No evidence for XMRV association in pediatric idiopathic diseases in France. Retrovirology. 2010;7:63 pubmed publisher
    ..None of the samples tested was positive for XMRV or MLV-like env sequences, indicating that XMRV is not involved in these pathologies...
  18. Baliji S, Liu Q, Kozak C. Common inbred strains of the laboratory mouse that are susceptible to infection by mouse xenotropic gammaretroviruses and the human-derived retrovirus XMRV. J Virol. 2010;84:12841-9 pubmed publisher
    ..This resistance to exogenous infection is due to a nonpermissive variant of the XPR1 gammaretrovirus receptor, a resistance that also limits in vivo expression of germ line X-MLV proviruses capable of producing ..
  19. Logg C, Baranick B, Lemp N, Kasahara N. Adaptive evolution of a tagged chimeric gammaretrovirus: identification of novel cis-acting elements that modulate splicing. J Mol Biol. 2007;369:1214-29 pubmed
    ..replication-competent MLV by replacing the native env gene in a full-length viral genome with that of another gammaretrovirus. Earlier, we developed replication-competent versions of MLV that stably transmit and express transgenes ..
  20. Ellis J. Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther. 2005;16:1241-6 pubmed
    ..In the case of gammaretrovirus vectors based on murine leukemia virus, many integration events are completely silenced in undifferentiated ..
  21. Howard T, Sheng Z, Wang M, Wu Y, Rasheed S. Molecular and phylogenetic analyses of a new amphotropic murine leukemia virus (MuLV-1313). Virol J. 2006;3:101 pubmed
  22. Bromham L, Clark F, McKee J. Discovery of a novel murine type C retrovirus by data mining. J Virol. 2001;75:3053-7 pubmed
    ..This virus is present in multiple copies in the mouse genome and expressed in a range of mouse tissues...
  23. Hong P, Li J, Li Y. Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome. Virol J. 2010;7:224 pubmed publisher
    ..The assay was standardized by constructing plasmid DNAs and armored RNAs as XMRV standards and competitive internal controls (CICs), respectively...
  24. Li C, Xiong D, Stamatoyannopoulos G, Emery D. Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol Ther. 2009;17:716-24 pubmed publisher
  25. Yan Y, Buckler White A, Wollenberg K, Kozak C. Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus. Proc Natl Acad Sci U S A. 2009;106:3259-63 pubmed publisher
    ..This analysis suggests that Fv1 has had an antiviral role throughout Mus evolution predating exposure of mice to the MLVs restricted by laboratory mouse Fv1, and suggests a mechanism for Fv1 restriction...
  26. Stocking C, Kozak C. Murine endogenous retroviruses. Cell Mol Life Sci. 2008;65:3383-98 pubmed publisher
    ..We review mechanisms by which an adaptive coexistence has evolved. (Part of a multi-author review)...
  27. Qiu X, Swanson P, Luk K, Tu B, Villinger F, Das Gupta J, et al. Characterization of antibodies elicited by XMRV infection and development of immunoassays useful for epidemiologic studies. Retrovirology. 2010;7:68 pubmed publisher
    Xenotropic Murine Leukemia Virus-related Virus (XMRV) is a human gammaretrovirus recently identified in prostate cancer tissue and in lymphocytes of patients with chronic fatigue syndrome...
  28. Strang B, Ikeda Y, Cosset F, Collins M, Takeuchi Y. Characterization of HIV-1 vectors with gammaretrovirus envelope glycoproteins produced from stable packaging cells. Gene Ther. 2004;11:591-8 pubmed
    ..High-titre HIV-1 vectors bearing gammaretrovirus envelopes (Env) are continuously produced from STAR cells...
  29. Bushman F. Retroviral integration and human gene therapy. J Clin Invest. 2007;117:2083-6 pubmed
  30. Fiebig U, Hartmann M, Bannert N, Kurth R, Denner J. Transspecies transmission of the endogenous koala retrovirus. J Virol. 2006;80:5651-4 pubmed
    The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis...
  31. Schwarzwaelder K, Howe S, Schmidt M, Brugman M, Deichmann A, Glimm H, et al. Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest. 2007;117:2241-9 pubmed
    We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene transfer...
  32. Elleder D, Kim O, Padhi A, Bankert J, Simeonov I, Schuster S, et al. Polymorphic integrations of an endogenous gammaretrovirus in the mule deer genome. J Virol. 2012;86:2787-96 pubmed publisher
    ..Here we report on a novel endogenous gammaretrovirus (CrERV?; for cervid endogenous gammaretrovirus) in the mule deer (Odocoileus hemionus) that is insertionally ..
  33. Baum C, Eckert H, Stockschlader M, Just U, Hegewisch Becker S, Hildinger M, et al. Improved retroviral vectors for hematopoietic stem cell protection and in vivo selection. J Hematother. 1996;5:323-9 pubmed
  34. Cornelissen M, Zorgdrager F, Blom P, Jurriaans S, Repping S, van Leeuwen E, et al. Lack of detection of XMRV in seminal plasma from HIV-1 infected men in The Netherlands. PLoS ONE. 2010;5:e12040 pubmed publisher
    Xenotropic murine leukaemia virus-related virus (XMRV) is a recently discovered human gammaretrovirus with yet unknown prevalence and transmission route(s)...
  35. Rodriguez J, Goff S. Xenotropic murine leukemia virus-related virus establishes an efficient spreading infection and exhibits enhanced transcriptional activity in prostate carcinoma cells. J Virol. 2010;84:2556-62 pubmed publisher
    Xenotropic murine leukemia virus-related virus (XMRV) is a novel human gammaretrovirus discovered in association with human prostate tumors...
  36. Gaspar H, Parsley K, Howe S, King D, Gilmour K, Sinclair J, et al. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet. 2004;364:2181-7 pubmed
    ..We investigated the application of somatic gene therapy by use of a gibbon-ape-leukaemia-virus pseudotyped gammaretroviral vector...
  37. Hong S, Klein E, Das Gupta J, Hanke K, Weight C, Nguyen C, et al. Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer. J Virol. 2009;83:6995-7003 pubmed publisher
  38. Hacein Bey Abina S, Garrigue A, Wang G, Soulier J, Lim A, Morillon E, et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. 2008;118:3132-42 pubmed publisher
    ..Successful chemotherapy was associated with restoration of polyclonal transduced T cell populations. As a result, the treated patients continued to benefit from therapeutic gene transfer...
  39. Dewannieux M, Collins M. Spontaneous heteromerization of gammaretrovirus envelope proteins: a possible novel mechanism of retrovirus restriction. J Virol. 2008;82:9789-94 pubmed publisher
    ..Here we show that pairs of gammaretrovirus envelope proteins (from Friend virus and GALV or xenotropic viruses) assemble into heteromers when ..
  40. Aker M, Tubb J, Miller D, Stamatoyannopoulos G, Emery D. Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection. Mol Ther. 2006;14:226-35 pubmed
    ..We report here on the integration pattern of a gammaretrovirus reporter vector following transduction and ex vivo culture of primary mouse bone marrow progenitor cells in ..
  41. Nishino T, Tubb J, Emery D. Partial correction of murine beta-thalassemia with a gammaretrovirus vector for human gamma-globin. Blood Cells Mol Dis. 2006;37:1-7 pubmed
    ..Similarly promising results have not yet been obtained with recombinant gammaretrovirus vectors...
  42. Lamere S, St Leger J, Schrenzel M, Anthony S, Rideout B, Salomon D. Molecular characterization of a novel gammaretrovirus in killer whales (Orcinus orca). J Virol. 2009;83:12956-67 pubmed publisher
    ..We examined tissues from adult killer whales and detected a novel gammaretrovirus by degenerate PCR. Reverse transcription-PCR also demonstrated tissue and serum expression of retroviral mRNA...
  43. Elfaitouri A, Shao X, Mattsson Ulfstedt J, Muradrasoli S, Bölin Wiener A, Golbob S, et al. Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. PLoS ONE. 2011;6:e24602 pubmed publisher
  44. Tailor C, Lavillette D, Marin M, Kabat D. Cell surface receptors for gammaretroviruses. Curr Top Microbiol Immunol. 2003;281:29-106 pubmed
    ..See Prassolov, Y., Zhang, D., Ivanov, D., Lohler, J., Ross, S.R., and Stocking, C. Sodium-dependent myo-inositol transporter 1 is a receptor for Mus cervicolor M813 murine leukemia virus...
  45. Yan Y, Knoper R, Kozak C. Wild mouse variants of envelope genes of xenotropic/polytropic mouse gammaretroviruses and their XPR1 receptors elucidate receptor determinants of virus entry. J Virol. 2007;81:10550-7 pubmed publisher
    ..susceptibility to XMVs is the ancestral type in this genus and that the phenotypic variants of mouse XPR1 likely arose in conjunction with exposure to gammaretrovirus infections and coevolutionary adaptations in the viral envelope.
  46. Ponferrada V, Mauck B, Wooley D. The envelope glycoprotein of human endogenous retrovirus HERV-W induces cellular resistance to spleen necrosis virus. Arch Virol. 2003;148:659-75 pubmed
    ..Spleen necrosis virus (SNV), a gammaretrovirus was chosen for testing resistance because it uses RDR to enter cells...
  47. Hilbert D, Kopf M, Mock B, Kohler G, Rudikoff S. Interleukin 6 is essential for in vivo development of B lineage neoplasms. J Exp Med. 1995;182:243-8 pubmed
    ..These studies define the essential role of IL-6 in the development of B lineage tumors in vivo and provide experimental support for continued efforts to modulate this cytokine in the treatment of appropriate human B cell malignancies. ..
  48. Friis K, Iturrioz X, Thomsen J, Alvear Perez R, Bahrami S, Llorens Cortes C, et al. Directed Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities. J Virol. 2016;90:1647-56 pubmed publisher
    We have previously reported the construction of a murine leukemia virus-based replication-competent gammaretrovirus (SL3-AP) capable of utilizing the human G protein-coupled receptor APJ (hAPJ) as its entry receptor and its natural ..
  49. Xu W, Eiden M. Koala Retroviruses: Evolution and Disease Dynamics. Annu Rev Virol. 2015;2:119-34 pubmed publisher
    ..Here, our current understanding of the evolution of endogenous and exogenous KoRVs, and the relationship between them, is reviewed to build a perspective on the future impact of these viruses on koala sustainability. ..
  50. Moon H, Park S, Kim H, Ann S, Rho S, Keum H, et al. Simultaneous detection and subtyping of porcine endogenous retroviruses proviral DNA using the dual priming oligonucleotide system. J Vet Sci. 2010;11:269-71 pubmed
    ..Thus, the multiplex PCR developed in the current study using DPO-based primers is a rapid, sensitive and specific assay for the detection and subtyping of PERV proviral genes. ..
  51. Badorrek C, Weeks K. RNA flexibility in the dimerization domain of a gamma retrovirus. Nat Chem Biol. 2005;1:104-11 pubmed
    ..These findings support a structural model in which RNA flexibility directly facilitates retroviral genome dimerization by reducing the energetic cost of disrupting pre-existing base pairings in the monomer...
  52. Cheslock S, Poon D, Fu W, Rhodes T, Henderson L, Nagashima K, et al. Charged assembly helix motif in murine leukemia virus capsid: an important region for virus assembly and particle size determination. J Virol. 2003;77:7058-66 pubmed
    ..quot; This is the first description of the charged assembly helix motif in MLV CA and demonstration of its role in virus budding and assembly...
  53. Neff T, Gerull S, Peterson L, Kiem H. Improved short-term engraftment of lentivirally versus gammaretrovirally transduced allogeneic canine repopulating cells. J Gene Med. 2007;9:357-61 pubmed
    ..These data suggest that short lentiviral transduction protocols may be superior to extended gammaretroviral transduction protocols with respect to engraftment potential of transduced CD34(+) hematopoietic repopulating cells...
  54. Van der Meer J, Netea M, Galama J, van Kuppeveld F. Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome". Science. 2010;328:825; author reply 825 pubmed publisher
    Lombardi et al. (Reports, 23 October 2009, p. 585) reported detection of the human gammaretrovirus XMRV in the blood cells of patients with chronic fatigue syndrome (CFS). However, the patient description provided was incomplete...
  55. Galvan D, Nakazawa Y, Kaja A, Kettlun C, Cooper L, Rooney C, et al. Genome-wide mapping of PiggyBac transposon integrations in primary human T cells. J Immunother. 2009;32:837-44 pubmed publisher
    ..Hence the piggyBac nonviral gene delivery system seems to represent a promising gene transfer system for clinical applications using human T lymphocytes...