epsilonretrovirus

Summary

Summary: A genus in the family RETROVIRIDAE infecting fish. Species include Walleye dermal sarcoma virus, Walleye epidermal hyperplasia virus 1, and Walleye epidermal hyperplasia virus 2.

Top Publications

  1. Nishizawa T, Kokawa Y, Wakayama T, Kinoshita S, Yoshimizu M. Enhanced propagation of fish nodaviruses in BF-2 cells persistently infected with snakehead retrovirus (SnRV). Dis Aquat Organ. 2008;79:19-25 pubmed publisher
    ..The amount of nodavirus cDNA in SJNNV-inoculated PI-BF-2 cells was clearly lower than that in SJNNV-inoculated SSN-1 cells...
  2. Martin J, Cao S, Maldonado J, Zhang W, Mansky L. Distinct Particle Morphologies Revealed through Comparative Parallel Analyses of Retrovirus-Like Particles. J Virol. 2016;90:8074-84 pubmed publisher
    ..created from all representative retroviral genera: Alpharetrovirus, Betaretrovirus, Deltaretrovirus, Epsilonretrovirus, Gammaretrovirus, Lentivirus, and Spumavirus...
  3. Brown K, Moreton J, Malla S, Aboobaker A, Emes R, Tarlinton R. Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing. Virology. 2012;433:55-63 pubmed publisher
    ..Using this novel approach provided a more technically feasible method to characterise ERV expression than previous studies...
  4. Holzschu D, Lapierre L, Lairmore M. Comparative pathogenesis of epsilonretroviruses. J Virol. 2003;77:12385-91 pubmed
  5. Hronek B, Meagher A, Rovnak J, Quackenbush S. Identification and characterization of cis-acting elements residing in the walleye dermal sarcoma virus promoter. J Virol. 2004;78:7590-601 pubmed
    ..EMSA utilizing the 15-bp repeat probe revealed that there are similarities of binding with W12 cell and developing-tumor nuclear extracts and that the binding differs from that observed with regressing-tumor nuclear extract...
  6. Paul T, Rovnak J, Quackenbush S, WHITLOCK K, Zhan H, Gong Z, et al. Transgenic expression of walleye dermal sarcoma virus rv-cyclin (orfA) in zebrafish does not result in tissue proliferation. Mar Biotechnol (NY). 2011;13:142-50 pubmed publisher
    ..These data indicate that rv-cyclin is not independently sufficient for tumor induction in zebrafish...
  7. Rovnak J, Quackenbush S. Walleye dermal sarcoma virus retroviral cyclin directly contacts TAF9. J Virol. 2006;80:12041-8 pubmed publisher
    ..A similar motif is present in the rv-cyclin AD, and point mutations within this motif affect rv-cyclin function and protein-protein interactions. The results support a model of transcription regulation by direct interaction with TAF9...
  8. Fodor S, Vogt V. Characterization of the protease of a fish retrovirus, walleye dermal sarcoma virus. J Virol. 2002;76:4341-9 pubmed
    Three fish retroviruses infecting walleyes constitute the recently recognized genus called epsilonretrovirus. The founding member of this group, walleye dermal sarcoma virus (WDSV), induces benign skin tumors in the infected fish and ..
  9. Daniels C, Rovnak J, Quackenbush S. Walleye dermal sarcoma virus Orf B functions through receptor for activated C kinase (RACK1) and protein kinase C. Virology. 2008;375:550-60 pubmed publisher
    ..Orf B associates with PKCalpha, which is constitutively activated and localized at the membrane. Activated PKC promoted cell survival, proliferation, and increased cell viability in Orf B-expressing cells...

More Information

Publications21

  1. Quackenbush S, Linton A, Brewster C, Rovnak J. Walleye dermal sarcoma virus rv-cyclin inhibits NF-kappaB-dependent transcription. Virology. 2009;386:55-60 pubmed publisher
    ..Furthermore, interference with NF-kappaB is dependent upon an intact TAF9-binding motif in rv-cyclin. The outcome of this NF-kappaB down regulation is likely to be important in the control of virus replication and tumorigenesis...
  2. Ribet D, Louvet Vallee S, Harper F, de Parseval N, Dewannieux M, Heidmann O, et al. Murine endogenous retrovirus MuERV-L is the progenitor of the "orphan" epsilon viruslike particles of the early mouse embryo. J Virol. 2008;82:1622-5 pubmed
    ..Using expression vectors for cloned, full-length, entirely coding MuERV-L copies and cell transfection, direct identification of the epsilon particles was finally achieved by high-resolution electron microscopy...
  3. Xu K, Zhang T, Wang L, Zhang C, Zhang L, Ma L, et al. Walleye dermal sarcoma virus: expression of a full-length clone or the rv-cyclin (orf a) gene is cytopathic to the host and human tumor cells. Mol Biol Rep. 2013;40:1451-61 pubmed publisher
    ..This is the first fish provirus clone that has been expressed in cell culture system, which will provide a new in vitro model for tumor research and oncotherapy study...
  4. Rovnak J, Brewster C, Quackenbush S. Retroviral cyclin enhances cyclin-dependent kinase-8 activity. J Virol. 2012;86:5742-51 pubmed publisher
  5. Zhan H, Spitsbergen J, Qing W, Wu Y, Paul T, Casey J, et al. Transgenic expression of walleye dermal sarcoma virus rv-cyclin gene in zebrafish and its suppressive effect on liver tumor development after carcinogen treatment. Mar Biotechnol (NY). 2010;12:640-9 pubmed publisher
    ..These findings indicate that transgenic fish models are powerful systems for investigating mechanisms of inhibition and regression of liver tumors...
  6. Bowser P, Abou Madi N, Garner M, Bartlett S, Grimmett S, Wooster G, et al. Fibrosarcoma in yellow perch, Perca flavescens (Mitchill). J Fish Dis. 2005;28:301-5 pubmed
  7. Bagossi P, Sperka T, Fehér A, Kadas J, Zahuczky G, Miklossy G, et al. Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites. J Virol. 2005;79:4213-8 pubmed
    ..In most cases the P2 residues of naturally occurring type 1 cleavage site sequences of the studied proteases agreed well with the observed P2 preferences...
  8. Rovnak J, Hronek B, Ryan S, Cai S, Quackenbush S. An activation domain within the walleye dermal sarcoma virus retroviral cyclin protein is essential for inhibition of the viral promoter. Virology. 2005;342:240-51 pubmed
    ..When fused to glutathione S-transferase, the rv-cyclin, its carboxy region, and the activation domain pull down components of transcription complexes from nuclear extracts, and pull down is lost by mutation of the activation domain...
  9. Brewster C, Birkenheuer C, Vogt M, Quackenbush S, Rovnak J. The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8. Virology. 2011;409:299-307 pubmed publisher
    ..Co-IP and pulldowns demonstrate direct rv-cyclin binding to cdk3 as well. The rv-cyclin functions as a structural ortholog of cyclin C in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins...
  10. Nudson W, Rovnak J, Buechner M, Quackenbush S. Walleye dermal sarcoma virus Orf C is targeted to the mitochondria. J Gen Virol. 2003;84:375-81 pubmed
    ..These results imply a functional role for WDSV Orf C in an alteration of mitochondrial function that results in apoptosis contributing to tumour regression...
  11. Rovnak J, Quackenbush S. Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme. J Virol. 2002;76:8031-9 pubmed
    ..These data suggest that WDSV OrfA functions through its interactions with these large, transcription complexes. Further investigations will clarify the role of the retrovirus cyclin in control of virus expression and transformation...
  12. Fodor S, Vogt V. Walleye dermal sarcoma virus reverse transcriptase is temperature sensitive. J Gen Virol. 2002;83:1361-5 pubmed