mason pfizer monkey virus

Summary

Summary: A species of BETARETROVIRUS isolated from mammary carcinoma in rhesus monkeys. It appears to have evolved from a recombination between a murine B oncovirus and a primate C oncovirus related to the baboon endogenous virus. Several serologically distinct strains exist. MPMV induces SIMIAN AIDS.

Top Publications

  1. Sfakianos J, Hunter E. M-PMV capsid transport is mediated by Env/Gag interactions at the pericentriolar recycling endosome. Traffic. 2003;4:671-80 pubmed
    ..Thus, for the first time, endocytic trafficking of a retroviral Env glycoprotein is linked to the efficient cytoplasmic transport of Gag...
  2. Blot V, Lopez Verges S, Breton M, Pique C, Berlioz Torrent C, Grange M. The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking. Retrovirology. 2006;3:62 pubmed
    ..Because both components are translated in different intracellular compartments, elucidating the mechanisms of retrovirus assembly thus requires the study of their intracellular trafficking...
  3. Song C, Dubay S, Hunter E. A tyrosine motif in the cytoplasmic domain of mason-pfizer monkey virus is essential for the incorporation of glycoprotein into virions. J Virol. 2003;77:5192-200 pubmed
    ..Antibody uptake studies show that tyrosine 22 is part of an efficient internalization signal in the cytoplasmic domain of the M-PMV glycoprotein that can also be positively and negatively influenced by changes at this site...
  4. Browning M, Schmidt R, Lew K, Rizvi T. Primate and feline lentivirus vector RNA packaging and propagation by heterologous lentivirus virions. J Virol. 2001;75:5129-40 pubmed
  5. Schmidt R, Mustafa F, Lew K, Browning M, Rizvi T. Sequences within both the 5' untranslated region and the gag gene are important for efficient encapsidation of Mason-Pfizer monkey virus RNA. Virology. 2003;309:166-78 pubmed
    ..Thus, sequences that affect MPMV RNA packaging seem to reside both upstream and downstream of the major splice donor with the downstream region responsible for the efficient functioning of the upstream primary packaging determinant...
  6. Song C, Hunter E. Variable sensitivity to substitutions in the N-terminal heptad repeat of Mason-Pfizer monkey virus transmembrane protein. J Virol. 2003;77:7779-85 pubmed
  7. Gottwein E, Bodem J, Muller B, Schmechel A, Zentgraf H, Kräusslich H. The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release. J Virol. 2003;77:9474-85 pubmed
    ..Consistent with a role of VPS4A in the budding of both PPPY and PTAP motif-containing viruses, the overexpression of ATPase-defective GFP-VPS4A fusion proteins blocked both wild-type and PSAP mutant virus release...
  8. Bogerd H, Echarri A, Ross T, Cullen B. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J Virol. 1998;72:8627-35 pubmed
    ..In addition, these data identify a novel and highly potent inhibitor of leucine-rich NES-dependent nuclear export...
  9. Kang Y, Cullen B. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes Dev. 1999;13:1126-39 pubmed
    ..Together, these data validate Tap as the first human sequence-specific nuclear mRNA export factor and identify a novel type of NES that can support nuclear mRNA export but does not act via Crm1...

More Information

Publications83

  1. Zábranský A, Sakalian M, Pichova I. Localization of self-interacting domains within betaretrovirus Gag polyproteins. Virology. 2005;332:659-66 pubmed
  2. Snasel J, Krejcik Z, Jencova V, Rosenberg I, Ruml T, Alexandratos J, et al. Integrase of Mason-Pfizer monkey virus. FEBS J. 2005;272:203-16 pubmed
  3. Mager D, Freeman J. Novel mouse type D endogenous proviruses and ETn elements share long terminal repeat and internal sequences. J Virol. 2000;74:7221-9 pubmed
    ..Furthermore, these results suggest that ETn transcripts retrotranspose using proteins provided by MusD proviruses...
  4. Wilkinson R, Murrell C, Guy R, Davis G, Hall J, North D, et al. Persistence and dissemination of simian retrovirus type 2 DNA in relation to viremia, seroresponse, and experimental transmissibility in Macaca fascicularis. J Virol. 2003;77:10751-9 pubmed
    ..These results indicate that a proportion of M. fascicularis are able to effectively control the replication and infectivity of SRV despite long-term persistence of viral DNA forms in infected lymphocytes...
  5. Blaise S, Mangeney M, Heidmann T. The envelope of Mason-Pfizer monkey virus has immunosuppressive properties. J Gen Virol. 2001;82:1597-600 pubmed
    ..Here, it is shown that this property is not restricted to the envelope of a murine retrovirus, but is also shared by the envelope encoded by a primate retrovirus, Mason-Pfizer monkey virus...
  6. Weldon R, Sarkar P, Brown S, Weldon S. Mason-Pfizer monkey virus Gag proteins interact with the human sumo conjugating enzyme, hUbc9. Virology. 2003;314:62-73 pubmed
  7. Barabas O, Rumlova M, Erdei A, Pongrácz V, Pichova I, Vertessy B. dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency. J Biol Chem. 2003;278:38803-12 pubmed
    ..Binding of the hexanucleotide ACTGCC or the octanucleotide (TG)4 to NC-dUTPase modulates enzymatic function, indicating that the low catalytic activity may be compensated by adequate localization...
  8. Sfakianos J, LaCasse R, Hunter E. The M-PMV cytoplasmic targeting-retention signal directs nascent Gag polypeptides to a pericentriolar region of the cell. Traffic. 2003;4:660-70 pubmed
    ..Thus the previously defined cytoplasmic targeting-retention signal appears to act as a cotranslational intracellular targeting signal that concentrates Gag proteins at the centriole for assembly of capsids...
  9. Hlavaty J, Schittmayer M, Stracke A, Jandl G, Knapp E, Felber B, et al. Effect of posttranscriptional regulatory elements on transgene expression and virus production in the context of retrovirus vectors. Virology. 2005;341:1-11 pubmed
    ..These data suggest that only the WPRE is a suitable element for the improvement of transgene expression and oncoretroviral vector production...
  10. Zábranská H, Tuma R, Kluh I, Svatos A, Ruml T, Hrabal R, et al. The role of the S-S bridge in retroviral protease function and virion maturation. J Mol Biol. 2007;365:1493-504 pubmed
    ..Thus, in addition to the protease disulfide bridge, reversible oxidation of cysteine and/or methionine residues in other domains of the Gag polyprotein or in related cellular proteins must be involved in the regulation of maturation. ..
  11. dib Hajj F, Khan R, Giedroc D. Retroviral nucleocapsid proteins possess potent nucleic acid strand renaturation activity. Protein Sci. 1993;2:231-43 pubmed
    ..The finding of significant nucleic acid strand renaturation activity may have important implications for various events of reverse transcription particularly in initiation and cDNA strand transfer. ..
  12. Hong S, Choi G, Park S, Chung A, Hunter E, Rhee S. Type D retrovirus Gag polyprotein interacts with the cytosolic chaperonin TRiC. J Virol. 2001;75:2526-34 pubmed
    ..Consequently, properly folded Gag molecules carry out the intermolecular interactions involved in self-assembly of the immature capsid. ..
  13. Füzik T, Píchalová R, Schur F, Strohalmová K, Křížová I, Hadravová R, et al. Nucleic Acid Binding by Mason-Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging. J Virol. 2016;90:4593-4603 pubmed publisher
    ..It is also crucial for packaging the viral genome and thus for infectivity. These data indicate that, surprisingly, interactions between the capsid domain and RNA play an important role in the assembly of M-PMV. ..
  14. Guesdon F, Greatorex J, Rhee S, Fisher R, Hunter E, Lever A. Sequences in the 5' leader of Mason-Pfizer monkey virus which affect viral particle production and genomic RNA packaging: development of MPMV packaging cell lines. Virology. 2001;288:81-8 pubmed
    ..Stable cell lines were produced containing packaging-defective virus. These first-generation packaging cell lines were used to package and transfer an MPMV-based vector. ..
  15. Parker S, Hunter E. Activation of the Mason-Pfizer monkey virus protease within immature capsids in vitro. Proc Natl Acad Sci U S A. 2001;98:14631-6 pubmed
    ..The initiation of protease activity within immature capsids in vitro demonstrates that viral protease activity is sensitive to oxidation-reduction conditions, and that the viral protease can be activated in the absence of viral budding. ..
  16. Pocock G, Zimdars L, Yuan M, Eliceiri K, Ahlquist P, Sherer N. Diverse activities of viral cis-acting RNA regulatory elements revealed using multicolor, long-term, single-cell imaging. Mol Biol Cell. 2017;28:476-487 pubmed publisher
    ..Together these imaging assays constitute a tractable, systems-based platform for studying otherwise difficult to access spatiotemporal features of viral and cellular gene regulation. ..
  17. Dostálková A, Kaufman F, Krízová I, Kultová A, Strohalmová K, Hadravová R, et al. Mutations in the Basic Region of the Mason-Pfizer Monkey Virus Nucleocapsid Protein Affect Reverse Transcription, Genomic RNA Packaging, and the Virus Assembly Site. J Virol. 2018;92: pubmed publisher
    ..However, the onset of reverse transcription was delayed even in this mutant. In summary, the basic region in M-PMV Gag plays a key role in the packaging of genomic RNA and, consequently, in assembly and reverse transcription. ..
  18. Li B, Li X, Bai Y, Hou J, Ma M, Machida C. Simian retrovirus serogroup 2 constitutive transport element recognizes the ribosomal L10-like protein and translocon gamma subunit-like protein in a yeast three-hybrid assay. Virus Res. 2004;99:69-80 pubmed
    ..UV-crosslinking/immunoblot assays have verified the interaction of the CTE region with molecules immunologically reactive to antibodies recognizing the ribosomal L10-like protein. ..
  19. Narahara C, Yasuda J. Roles of the three L-domains in β-retrovirus budding. Microbiol Immunol. 2015;59:545-54 pubmed publisher
    ..On the other hand, the YADL motif was required for M-PMV production as a transport signal of Gag to the plasma membrane, but not as an L-domain. ..
  20. Macek P, Chmelik J, Krízová I, Kaderávek P, Padrta P, Zídek L, et al. NMR structure of the N-terminal domain of capsid protein from the mason-pfizer monkey virus. J Mol Biol. 2009;392:100-14 pubmed publisher
    ..This confirms that the mutual interaction and topology within the beta-hairpin and helix 3 might correlate with the changes in interaction between immature and mature lattices. ..
  21. Stansell E, Apkarian R, Haubova S, Diehl W, Tytler E, Hunter E. Basic residues in the Mason-Pfizer monkey virus gag matrix domain regulate intracellular trafficking and capsid-membrane interactions. J Virol. 2007;81:8977-88 pubmed publisher
    ..All mutants that released virions exhibited near-wild-type infectivity in a single-round assay. Thus, basic amino acids in the M-PMV MA define both cellular location and efficiency of virus release...
  22. Rizvi T, Schmidt R, Lew K. Mason-Pfizer monkey virus (MPMV) constitutive transport element (CTE) functions in a position-dependent manner. Virology. 1997;236:118-29 pubmed
    ..Together, these results demonstrate that the close proximity of CTE to the poly(A) signal is important for CTE function, suggesting a functional interaction between CTE and the polyadenylation machinery. ..
  23. Pocock G, Becker J, Swanson C, Ahlquist P, Sherer N. HIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors. PLoS Pathog. 2016;12:e1005565 pubmed publisher
    ..Combined, these results reveal striking, unexpected features of retroviral gRNA nucleocytoplasmic transport and demonstrate roles for mRNA export elements that extend beyond nuclear pores to impact gRNA distribution in the cytoplasm. ..
  24. Rumlova M, Benedíková J, Cubínková R, Pichova I, Ruml T. Comparison of classical and affinity purification techniques of Mason-Pfizer monkey virus capsid protein: the alteration of the product by an affinity tag. Protein Expr Purif. 2001;23:75-83 pubmed
    ..coli. We show here that the widely used histidine anchor may significantly alter the properties of the protein of interest. ..
  25. Sakalian M, Dittmer S, Gandy A, Rapp N, Zábranský A, Hunter E. The Mason-Pfizer monkey virus internal scaffold domain enables in vitro assembly of human immunodeficiency virus type 1 Gag. J Virol. 2002;76:10811-20 pubmed
    ..This continued requirement for HIV Gag domain function in the assembly of chimeric molecules will allow this in vitro system to be used for the analysis of potential inhibitors of HIV immature particle assembly. ..
  26. Duelli D, Hearn S, Myers M, Lazebnik Y. A primate virus generates transformed human cells by fusion. J Cell Biol. 2005;171:493-503 pubmed
    ..We also show that this virus can produce viable oncogenically transformed cells by fusing cells that are otherwise destined to die. Therefore, we argue that viruses can contribute to carcinogenesis by fusing cells. ..
  27. Junkova P, Prchal J, Spiwok V, Pleskot R, Kadlec J, Krasny L, et al. Molecular aspects of the interaction between Mason-Pfizer monkey virus matrix protein and artificial phospholipid membrane. Proteins. 2016;84:1717-1727 pubmed publisher
    ..Proteins 2016; 84:1717-1727. © 2016 Wiley Periodicals, Inc. ..
  28. Kroupa T, Langerová H, Dolezal M, Prchal J, Spiwok V, Hunter E, et al. Membrane Interactions of the Mason-Pfizer Monkey Virus Matrix Protein and Its Budding Deficient Mutants. J Mol Biol. 2016;428:4708-4722 pubmed publisher
    ..In our invivo experiments, the M-PMV MA did not co-localize with lipid rafts. Therefore, we concluded that M-PMV might adopt a different membrane binding mechanism than HIV-1. ..
  29. Knejzlík Z, Smékalová Z, Ruml T, Sakalian M. Multimerization of the p12 domain is necessary for Mason-Pfizer monkey virus Gag assembly in vitro. Virology. 2007;365:260-70 pubmed
    ..These data highlight the importance of a region containing alternating leucines and isoleucines within p12, but also indicate that this domain's scaffold-like function is more complex than small number oligomerization. ..
  30. Cho S, Pincus D, Thirumalai D. Assembly mechanisms of RNA pseudoknots are determined by the stabilities of constituent secondary structures. Proc Natl Acad Sci U S A. 2009;106:17349-54 pubmed publisher
    ..We also establish that assembly mechanisms can be predicted using the stabilities of the isolated secondary structures. ..
  31. Swartz J, Bor Y, Misawa Y, Rekosh D, Hammarskjold M. The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element. J Biol Chem. 2007;282:19844-53 pubmed
    ..These results provide further evidence for crucial links between RNA splicing, export and translation...
  32. Németh Pongrácz V, Barabas O, Fuxreiter M, Simon I, Pichova I, Rumlová M, et al. Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res. 2007;35:495-505 pubmed
    ..Structural and genomic advantages of fusing the NC domain to a shortened dUTPase in betaretroviruses and the possible physiological consequences are envisaged...
  33. Snasel J, Shoeman R, Horejsi M, Hruskova Heidingsfeldova O, Sedlacek J, Ruml T, et al. Cleavage of vimentin by different retroviral proteases. Arch Biochem Biophys. 2000;377:241-5 pubmed
    ..Vimentin was cleaved by all the proteases at different sites and with different rates. The results show that the physiologically important cellular protein vimentin can be degraded by different retroviral proteases...
  34. Coyle J, Guzik B, Bor Y, Jin L, Eisner Smerage L, Taylor S, et al. Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK. Mol Cell Biol. 2003;23:92-103 pubmed
    ..They also provide further evidence of links between signal transduction and RNA utilization...
  35. Ulbrich P, Haubova S, Nermut M, Hunter E, Rumlova M, Ruml T. Distinct roles for nucleic acid in in vitro assembly of purified Mason-Pfizer monkey virus CANC proteins. J Virol. 2006;80:7089-99 pubmed
    ..Thus, oligonucleotides may, through a transient interaction, induce conformational changes that facilitate assembly, while longer RNAs appear to facilitate the complete assembly of spherical particles...
  36. Barabas O, Németh V, Vertessy B. Crystallization and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:399-401 pubmed
    ..Native and PtCl4-derivative data sets were collected using synchrotron radiation to 1.75 and 2.3 angstroms, respectively. Phasing was successfully performed by isomorphous replacement combined with anomalous scattering...
  37. Wildová M, Hadravová R, Stokrova J, Krízová I, Ruml T, Hunter E, et al. The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity. Virology. 2008;380:157-63 pubmed publisher
    ..These data indicate that the region spanning residues Asp50-Asp57 plays an important role in stabilization of the beta-hairpin and that Asp57 likely forms a salt-bridge with P1 in M-PMV CA...
  38. Suptawiwat O, Lee T, Auewarakul P. HIV-1 Cis Enhancing Sequence (CES) enhances CTE-dependent Gag expression. Virology. 2005;342:111-8 pubmed
    ..Known hnRNP-A1-binding sites as well as other 3 highly conserved sequences in the CES were found to be required for its activity...
  39. Svec M, Bauerova H, Pichova I, Konvalinka J, Strisovsky K. Proteinases of betaretroviruses bind single-stranded nucleic acids through a novel interaction module, the G-patch. FEBS Lett. 2004;576:271-6 pubmed
    ..Oligonucleotide binding to both PRs does not inhibit their proteolytic activity...
  40. Coburn G, Wiegand H, Kang Y, Ho D, Georgiadis M, Cullen B. Using viral species specificity to define a critical protein/RNA interaction surface. Genes Dev. 2001;15:1194-205 pubmed
    ..These data emphasize the potential importance of cross-species genetic complementation in the identification and characterization of cellular factors that are critical for different aspects of viral replication...
  41. Mee E, Murrell C, Sauermann U, Wilkinson R, Cutler K, North D, et al. The Mhc class II DRB genotype of Macaca fascicularis does not influence infection by simian retrovirus type 2. Tissue Antigens. 2008;72:369-78 pubmed publisher
    ..A discordance with SRV-2 infection status suggests that an Mhc II DRB genotype is not overtly associated with the outcome of viral infection...
  42. Conte M, Klikova M, Hunter E, Ruml T, Matthews S. The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly. EMBO J. 1997;16:5819-26 pubmed
    ..In addition to this, the interpretation of mutagenesis data has enabled us to identify, for the first time, the structural basis of a putative intracellular targeting motif...
  43. Rumlova M, Ruml T, Pohl J, Pichova I. Specific in vitro cleavage of Mason-Pfizer monkey virus capsid protein: evidence for a potential role of retroviral protease in early stages of infection. Virology. 2003;310:310-8 pubmed
    ..The CA cleavage product was also identified shortly after penetration of M-PMV into COS cells, suggesting that the protease-catalyzed cleavage is involved in core disintegration...
  44. De Marco A, Davey N, Ulbrich P, Phillips J, Lux V, Riches J, et al. Conserved and variable features of Gag structure and arrangement in immature retrovirus particles. J Virol. 2010;84:11729-36 pubmed publisher
    ..We conclude that the arrangement of the structural domains of CA is well conserved across genera, whereas the relationship between CA, the spacer peptide region, and the nucleic acid is more specific to each genus...
  45. Nermut M, Bron P, Thomas D, Rumlova M, Ruml T, Hunter E. Molecular organization of Mason-Pfizer monkey virus capsids assembled from Gag polyprotein in Escherichia coli. J Virol. 2002;76:4321-30 pubmed
    ..NC domains. In addition, our results point to a key role of structurally constrained CA domain in the trimeric interaction of the Gag polyprotein...
  46. Parker S, Wall J, Hunter E. Analysis of Mason-Pfizer monkey virus Gag particles by scanning transmission electron microscopy. J Virol. 2001;75:9543-8 pubmed
    ..The masses of individual selected Gag particles were measured, and the average mass corresponded to 1,900 to 2,100 Gag polyproteins per particle. A large variation in Gag particle mass was observed within each population measured...
  47. Vile R. Viral mediated cell fusion: viral fusion--the making, or breaking, of a tumour?. Gene Ther. 2006;13:1127-30 pubmed
  48. Bagossi P, Sperka T, Fehér A, Kadas J, Zahuczky G, Miklossy G, et al. Amino acid preferences for a critical substrate binding subsite of retroviral proteases in type 1 cleavage sites. J Virol. 2005;79:4213-8 pubmed
    ..In most cases the P2 residues of naturally occurring type 1 cleavage site sequences of the studied proteases agreed well with the observed P2 preferences...
  49. Al Dhaheri N, Phillip P, Ghazawi A, Ali J, Beebi E, Jaballah S, et al. Cross-packaging of genetically distinct mouse and primate retroviral RNAs. Retrovirology. 2009;6:66 pubmed publisher
  50. Freed E. Viral late domains. J Virol. 2002;76:4679-87 pubmed
  51. Demirov D, Ono A, Orenstein J, Freed E. Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function. Proc Natl Acad Sci U S A. 2002;99:955-60 pubmed
    ..These data demonstrate a link between the E2-like domain of TSG101 and HIV-1 L domain function, and indicate that TSG101 derivatives can act as potent and specific inhibitors of HIV-1 replication by blocking virus budding...
  52. Callendret B, Lorin V, Charneau P, Marianneau P, Contamin H, Betton J, et al. Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS. Virology. 2007;363:288-302 pubmed
    ..Our observations are likely to be useful for the construction of plasmid and viral vectors designed for optimal expression of intronless genes derived from cytoplasmic RNA viruses...
  53. Levesque L, Guzik B, Guan T, Coyle J, Black B, Rekosh D, et al. RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex. J Biol Chem. 2001;276:44953-62 pubmed
    ..We propose that NXT1-dependent binding of the Tap-RNA complex to the nucleoporin p62, which we have reconstituted in vitro using recombinant proteins, represents a single step of the translocation reaction...
  54. Muthumani K, Zhang D, Dayes N, Hwang D, Calarota S, Choo A, et al. Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo. Virology. 2003;314:134-46 pubmed
    ..This study suggests a simple strategy for improving the expression and immunogenicity of HIV subtype-specific envelope antigens as plasmid or vector-borne immunogens...
  55. Mustafa F, Phillip P, Jayanth P, Ghazawi A, Lew K, Schmidt R, et al. Close proximity of the MPMV CTE to the polyadenylation sequences is important for efficient function in the subgenomic context. Virus Res. 2004;105:209-18 pubmed
    ..Our results reveal that similar to the genomic situation, close proximity of CTE to the polyadenylation sequences is important for its function in the heterologous subgenomic context...
  56. Vlach J, Lipov J, Veverka V, Rumlova M, Ruml T, Hrabal R. Assignment of 1H, 13C, and 15N resonances of WT matrix protein and its R55F mutant from Mason-Pfizer monkey virus. J Biomol NMR. 2005;31:381-2 pubmed
  57. Tang H, Xu Y, Wong Staal F. Identification and purification of cellular proteins that specifically interact with the RNA constitutive transport elements from retrovirus D. Virology. 1997;228:333-9 pubmed
    ..Both proteins have been partially purified. The nature of these proteins and their roles in RNA intracellular trafficking are currently under investigation...
  58. Bauerová Zábranská H, Stokrova J, Strisovsky K, Hunter E, Ruml T, Pichova I. The RNA binding G-patch domain in retroviral protease is important for infectivity and D-type morphogenesis of Mason-Pfizer monkey virus. J Biol Chem. 2005;280:42106-12 pubmed
  59. Chung H, Morita E, von Schwedler U, Muller B, Kräusslich H, Sundquist W. NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains. J Virol. 2008;82:4884-97 pubmed publisher
    ..These observations suggest that NEDD4L and possibly other NEDD4-like proteins can ubiquitylate and activate ESCRT-I to function in virus budding...
  60. Diehl W, Stansell E, Kaiser S, Emerman M, Hunter E. Identification of postentry restrictions to Mason-Pfizer monkey virus infection in New World monkey cells. J Virol. 2008;82:11140-51 pubmed publisher
    ..Our results demonstrate that TRIM5alpha specificity extends to betaretroviruses and suggest that New World monkeys have evolved additional mechanisms to restrict the infection of at least one primate betaretrovirus...
  61. Tang Y, Winkler U, Freed E, Torrey T, Kim W, Li H, et al. Cellular motor protein KIF-4 associates with retroviral Gag. J Virol. 1999;73:10508-13 pubmed
    ..The binding of Gag is mediated by a domain of KIF-4 proximal to the C terminus. These results, and our previous studies, raise the possibility that KIF-4 may play an important role in retrovirus Gag protein transport...
  62. Rizvi T, Schmidt R, Lew K, Keeling M. Rev/RRE-independent Mason-Pfizer monkey virus constitutive transport element-dependent propagation of SIVmac239 vectors using a single round of replication assay. Virology. 1996;222:457-63 pubmed
    ..Our results demonstrate that MPMV CTE is capable of substituting for SIV Rev and RRE functions, resulting in an attenuated ability to produce infectious virus...
  63. Philipp Staheli J, Marquardt T, Thouless M, Bruce A, Grant R, Tsai C, et al. Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species. Virol J. 2006;3:11 pubmed
  64. Vlach J, Lipov J, Rumlova M, Veverka V, Lang J, Srb P, et al. D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein. Proc Natl Acad Sci U S A. 2008;105:10565-70 pubmed publisher
    ..This conformational change buries a putative intracellular targeting motif located between both domains in the hydrophobic pocket of the MA molecule, thereby preventing the interaction with cellular transport mechanisms...
  65. Oh T, Bajwa A, Jia G, Park F. Lentiviral vector design using alternative RNA export elements. Retrovirology. 2007;4:38 pubmed
    ..Recent studies have attempted to replace the existing complex rev/RRE system with a more simplistic RNA export system from simple retroviruses to make these vectors in a rev-independent manner...
  66. Sakalian M, Rapp N. Rescue of internal scaffold-deleted Mason-Pfizer monkey virus particle production by plasma membrane targeting. Virology. 2006;345:317-27 pubmed
    ..These results provide support for a model in which the plasma membrane and the D-type ISD provide an interchangeable scaffold-like function in retrovirus assembly...
  67. Lebedev I, Bolorma V, Kzhishkovska I, Ostashkin A, Il in K, Miandina G, et al. [Integration of the type D Mason-Pfizer monkey virus into the human chromosome]. Mol Biol (Mosk). 2002;36:1012-4 pubmed
  68. Knejzlík Z, Ulbrich P, Strohalm M, Lastůvková H, Kodicek M, Sakalian M, et al. Conformational changes of the N-terminal part of Mason-Pfizer monkey virus p12 protein during multimerization. Virology. 2009;393:168-76 pubmed publisher
    ..Assembly into fibers is linked to a conformational transition from unfolded or another non-periodical state to alpha-helix during multimerization...
  69. Mustafa F, Lew K, Schmidt R, Browning M, Rizvi T. Mutational analysis of the predicted secondary RNA structure of the Mason-Pfizer monkey virus packaging signal. Virus Res. 2004;99:35-46 pubmed
    ..Finally, results of the biological effects of the structural mutations are discussed in relation to their effects on the folding potential of the various stem loops...
  70. Hull S, Boris Lawrie K. Analysis of synergy between divergent simple retrovirus posttranscriptional control elements. Virology. 2003;317:146-54 pubmed
    ..Our results uncovered a previously unidentified role of CTE in conjunction with Tap and NXT1 in commitment to efficient cytoplasmic RNA utilization...
  71. Veverka V, Bauerova H, Zábranský A, Lang J, Ruml T, Pichova I, et al. Three-dimensional structure of a monomeric form of a retroviral protease. J Mol Biol. 2003;333:771-80 pubmed
    ..This is consistent with the role of reversible oxidative modification of the cysteine residues in the regulation of the maturation of assembled M-PMV capsids in the cytoplasm...
  72. Hofmann W, Reichart B, Ewald A, Muller E, Schmitt I, Stauber R, et al. Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin. J Cell Biol. 2001;152:895-910 pubmed
    ..In summary, our data provide evidence that actin plays an important functional role in nuclear export not only of retroviral RNAs but also of host proteins such as protein kinase inhibitor (PKI)...
  73. Hull S, Boris Lawrie K. RU5 of Mason-Pfizer monkey virus 5' long terminal repeat enhances cytoplasmic expression of human immunodeficiency virus type 1 gag-pol and nonviral reporter RNA. J Virol. 2002;76:10211-8 pubmed
  74. Morozov V, Saal F, Gessain A, Terrinha A, Peries J. Antibodies to gag gene coded polypeptides of type D retroviruses in healthy people from Guinea-Bissau. Intervirology. 1991;32:253-7 pubmed
    ..In eight (25%) sera antibodies at least against p36 were detected. Among squirrel monkey retrovirus positive sera, three were also positive with p27 M-PMV. The other five were found to be M-PMV negative...