avian leukosis virus

Summary

Summary: The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.

Top Publications

  1. Cheng Z, Liu J, Cui Z, Zhang L. Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China. J Vet Med Sci. 2010;72:1027-33 pubmed
    ..the 3 years leading up to November 2009, 6 different types of naturally occurring neoplasms associated with avian leukosis virus subgroup J (ALV-J) were diagnosed by histopathology, polymerase chain reaction (PCR) and ..
  2. Xu B, Dong W, Yu C, He Z, Lv Y, Sun Y, et al. Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China. Avian Pathol. 2004;33:13-7 pubmed
    ..Immunohistochemical studies with a monoclonal antibody to gp85 of avian leukosis virus subgroup J (ALV-J) revealed antigen in all organs examined...
  3. Tam W, Hughes S, Hayward W, Besmer P. Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis. J Virol. 2002;76:4275-86 pubmed
    bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis...
  4. Meng Q, Zhang Z, Wang W, Tian J, Xiao Z. Enhanced inhibition of Avian leukosis virus subgroup J replication by multi-target miRNAs. Virol J. 2011;8:556 pubmed publisher
    b>Avian leukosis virus (ALV) is a major infectious disease that impacts the poultry industry worldwide. Despite intensive efforts, no effective vaccine has been developed against ALV because of mutations that lead to resistant forms...
  5. Lupiani B, Williams S, Silva R, Hunt H, Fadly A. Pathogenicity of two recombinant avian leukosis viruses. Avian Dis. 2003;47:425-32 pubmed
    ..and molecular characteristics of two recombinant avian leukosis subgroup J viruses (ALV J) with an avian leukosis virus subgroup A envelope (r5701A and r6803A)...
  6. Zhang H, Bacon L, Cheng H, Hunt H. Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns. Avian Pathol. 2005;34:324-31 pubmed
    The cellular receptor of subgroup B avian leukosis virus (ALVB) is encoded by a gene at the tumour virus B (TVB) locus...
  7. Lim K, Narayan S, Young J, Yin J. Effects of lipid rafts on dynamics of retroviral entry and trafficking: Quantitative analysis. Biotechnol Bioeng. 2004;86:650-60 pubmed
    ..Overall, the model provides a means to generate new experimentally testable hypotheses and sets a foundation for building a quantitative and integrated understanding of viral entry, trafficking, and intracellular dynamics...
  8. Landman W, Post J, Boonstra Blom A, Buyse J, Elbers A, Koch G. Effect of an in ovo infection with a Dutch avian leukosis virus subgroup J isolate on the growth and immunological performance of SPF broiler chickens. Avian Pathol. 2002;31:59-72 pubmed
    The effect of an in ovo infection with a Dutch isolate of avian leukosis virus subgroup J (ALV-J) on the growth of specific pathogen free (SPF) broiler chickens was analysed...
  9. Feng S, Cao W, Liao M. The PI3K/Akt pathway is involved in early infection of some exogenous avian leukosis viruses. J Gen Virol. 2011;92:1688-97 pubmed publisher
    b>Avian leukosis virus (ALV) is an enveloped and oncogenic retrovirus. Avian leukosis caused by the members of ALV subgroups A, B and J has become one of the major problems challenging the poultry industry in China...

More Information

Publications78

  1. Chesters P, Smith L, Nair V. E (XSR) element contributes to the oncogenicity of Avian leukosis virus (subgroup J). J Gen Virol. 2006;87:2685-92 pubmed
    Among the six subgroups of Avian leukosis virus (ALV) that infect chickens, subgroup J (ALV-J) was isolated from meat-type chickens where it predominantly induces myeloid leukosis (ML) and erythroblastosis (EB)...
  2. Sacco M, Flannery D, Howes K, Venugopal K. Avian endogenous retrovirus EAV-HP shares regions of identity with avian leukosis virus subgroup J and the avian retrotransposon ART-CH. J Virol. 2000;74:1296-306 pubmed
    ..elements in the chicken genome, designated EAV-HP, with close sequence identity to the env gene of avian leukosis virus (ALV) subgroup J has been reported (L. M. Smith, A. A. Toye, K. Howes, N. Bumstead, L. N. Payne, and K...
  3. Elleder D, Melder D, Trejbalova K, Svoboda J, Federspiel M. Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses. J Virol. 2004;78:13489-500 pubmed
    ..Line 7(2) tva(r2) contains a 4-bp insertion in exon 1 that causes a change in the reading frame, which blocks expression of the Tva receptor...
  4. Holmen S, Melder D, Federspiel M. Identification of key residues in subgroup A avian leukosis virus envelope determining receptor binding affinity and infectivity of cells expressing chicken or quail Tva receptor. J Virol. 2001;75:726-37 pubmed
    To better understand retroviral entry, we have characterized the interactions between subgroup A avian leukosis virus [ALV(A)] envelope glycoproteins and Tva, the receptor for ALV(A), that result in receptor interference...
  5. Earp L, Delos S, Netter R, Bates P, White J. The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pH. J Virol. 2003;77:3058-66 pubmed
    ..Possible roles for low pH at subsequent stages of viral entry are discussed. ..
  6. Shi M, Tian M, Liu C, Zhao Y, Lin Y, Zou N, et al. Sequence analysis for the complete proviral genome of subgroup J Avian Leukosis virus associated with hemangioma: a special 11 bp deletion was observed in U3 region of 3'UTR. Virol J. 2011;8:158 pubmed publisher
    b>Avian Leukosis virus (ALV) of subgroup J (ALV-J) belong to retroviruses, which could induce tumors in domestic and wild birds...
  7. Netter R, Amberg S, Balliet J, Biscone M, Vermeulen A, Earp L, et al. Heptad repeat 2-based peptides inhibit avian sarcoma and leukosis virus subgroup a infection and identify a fusion intermediate. J Virol. 2004;78:13430-9 pubmed
    ..These experiments support a model in which receptor interaction promotes formation of an envelope conformation in which the TM subunit is stably associated with its target membrane and is able to bind a C-terminal peptide...
  8. Sung H, Reddy S, Fadly A. High virus titer in feather pulp of chickens infected with subgroup J avian leukosis virus. Avian Dis. 2002;46:281-6 pubmed
    ..All above results indicate that samples of feather pulp can be useful for virus isolation and PCR to confirm subgroup J ALV infection...
  9. Zhang X, Liao M, Jiao P, Luo K, Zhang H, Ren T, et al. Development of a loop-mediated isothermal amplification assay for rapid detection of subgroup J avian leukosis virus. J Clin Microbiol. 2010;48:2116-21 pubmed publisher
    Infection of breeder flocks in China with subgroup J avian leukosis virus (ALV-J) has increased recently...
  10. Zhang H, Bacon L, Fadly A. Development of an endogenous virus-free line of chickens susceptible to all subgroups of avian leukosis virus. Avian Dis. 2008;52:412-8 pubmed
    ..This report documents the development of a new line of chickens, 0.TVB*S1, that is free of endogenous viruses and susceptible to all subgroups of ALV identified in chickens...
  11. Bagust T, Fenton S, Reddy M. Detection of subgroup J avian leukosis virus infection in Australian meat-type chickens. Aust Vet J. 2004;82:701-6 pubmed
    To determine the extent of avian leukosis virus subgroup J (ALV-J) infection in Australian broiler breeder flocks, using virus isolation and molecular biological detection...
  12. Liu C, Zheng S, Wang Y, Jing L, Gao H, Gao Y, et al. Detection and molecular characterization of recombinant avian leukosis viruses in commercial egg-type chickens in China. Avian Pathol. 2011;40:269-75 pubmed publisher
    ..These results suggested that the two isolates can be characterized as recombinant ALV-J with the internal env gene and 3'-UTR sequence of endogenous ALV...
  13. Cheng Z, Zhang L, Liu S, Zhang L, Cui Z. [Emerging of avian leukosis virus subgroup J in a flock of Chinese local breed]. Wei Sheng Wu Xue Bao. 2005;45:584-7 pubmed
    ..The results indicate that ALV-J already caused chickens infection and dead in Chinese local breed...
  14. Zhang H, Bacon L, Heidari M, Muir W, Groenen M, Zhang Y, et al. Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay. Avian Pathol. 2007;36:283-91 pubmed
    The tumour virus B (TVB) locus encodes cellular receptors mediating infection by three subgroups of avian leukosis virus (B, D, and E). Three major alleles, TVB*S1, TVB*S3, and TVB*R, have been described...
  15. Hue D, Dambrine G, Denesvre C, Laurent S, Wyers M, Rasschaert D. Major rearrangements in the E element and minor variations in the U3 sequences of the avian leukosis subgroup J provirus isolated from field myelocytomatosis. Arch Virol. 2006;151:2431-46 pubmed
    We collected paraffin-embedded myelocytomatoses induced by subgroup J avian leukosis virus (ALV-J) in French poultry from 1992 to 2000...
  16. Wang Q, Gao Y, Wang Y, Qin L, Qi X, Qu Y, et al. A 205-nucleotide deletion in the 3' untranslated region of avian leukosis virus subgroup J, currently emergent in China, contributes to its pathogenicity. J Virol. 2012;86:12849-60 pubmed publisher
    In the past 5 years, an atypical clinical outbreak of avian leukosis virus subgroup J (ALV-J), which contains a unique 205-nucleotide deletion in its 3' untranslated region (3'UTR), has become epidemic in chickens in China...
  17. Melder D, Pankratz V, Federspiel M. Evolutionary pressure of a receptor competitor selects different subgroup a avian leukosis virus escape variants with altered receptor interactions. J Virol. 2003;77:10504-14 pubmed
    ..Alterations in the normally extreme specificity of the ALV(A) glycoproteins for Tva may represent an evolutionary first step toward expanding viral receptor usage in response to inefficient viral entry...
  18. Elleder D, Stepanets V, Melder D, Senigl F, Geryk J, Pajer P, et al. The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily. J Virol. 2005;79:10408-19 pubmed
    ..We have also identified a mutation in the tvc gene in line L15 chickens that explains why this line is resistant to ASLV(C) infection...
  19. Chang C, Coville J, Coquerelle G, Gourichon D, Oulmouden A, Tixier Boichard M. Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens. BMC Genomics. 2006;7:19 pubmed
    ..The albino mutation was found to be a 6 bp deletion in the tyrosinase (TYR) gene. The present work describes an approach to identify the structural rearrangement in the TYR gene associated with the recessive white mutation...
  20. Wang H, Cui Z. [The identification and sequence analysis of ALV-J isolated from layers]. Bing Du Xue Bao. 2008;24:369-75 pubmed
  21. Cui Z, Sun S, Zhang Z, Meng S. Simultaneous endemic infections with subgroup J avian leukosis virus and reticuloendotheliosis virus in commercial and local breeds of chickens. Avian Pathol. 2009;38:443-8 pubmed publisher
    Epidemiological studies of subgroup J avian leukosis virus (ALV-J) and reticuloendotheliosis virus (REV) infections were conducted during 1999 to 2009 on 29 chicken flocks of various commercial and local breeds located in six provinces in ..
  22. Pan W, Gao Y, Sun F, Qin L, Liu Z, Yun B, et al. Novel sequences of subgroup J avian leukosis viruses associated with hemangioma in Chinese layer hens. Virol J. 2011;8:552 pubmed publisher
    b>Avian leukosis virus subgroup J (ALV-J) preferentially induces myeloid leukosis (ML) in meat-type birds...
  23. Barnard R, Young J. Alpharetrovirus envelope-receptor interactions. Curr Top Microbiol Immunol. 2003;281:107-36 pubmed
    ..In addition, we review data pertaining to the novel two-step entry mechanism of ASLV entry and propose a model by which ASLV Env elicits membrane fusion...
  24. Chesters P, Howes K, McKay J, Payne L, Venugopal K. Acutely transforming avian leukosis virus subgroup J strain 966: defective genome encodes a 72-kilodalton Gag-Myc fusion protein. J Virol. 2001;75:4219-25 pubmed
    b>Avian leukosis virus subgroup J (ALV-J), the most recent member of the avian retroviruses, is predominantly associated with myeloid leukosis in meat-type chickens...
  25. Lai H, Zhang H, Ning Z, Chen R, Zhang W, Qing A, et al. Isolation and characterization of emerging subgroup J avian leukosis virus associated with hemangioma in egg-type chickens. Vet Microbiol. 2011;151:275-83 pubmed publisher
    Subgroup J avian leukosis virus (ALV-J), first isolated in 1989, predominantly causes myeloid leukosis (ML) in meat-type or egg-type chicken...
  26. Sun S, Cui Z. Epidemiological and pathological studies of subgroup J avian leukosis virus infections in Chinese local "yellow" chickens. Avian Pathol. 2007;36:221-6 pubmed
    Epidemiological, pathological and molecular studies indicate that subgroup J avian leukosis virus (ALV-J) infections are widely spread in "yellow chickens" of local breeds in China...
  27. Payne L, Nair V. The long view: 40 years of avian leukosis research. Avian Pathol. 2012;41:11-9 pubmed publisher
    ..Other work was performed by agricultural scientists interested in poultry disease. Interests of the two groups have overlapped, particularly as a result of a shift of emphasis to molecular biology research...
  28. Pandiri A, Reed W, Mays J, Fadly A. Influence of strain, dose of virus, and age at inoculation on subgroup J avian leukosis virus persistence, antibody response, and oncogenicity in commercial meat-type chickens. Avian Dis. 2007;51:725-32 pubmed
    The effects of viral strain, viral dose, and age of bird at inoculation on subgroup J avian leukosis virus (ALV J) persistence, neutralizing antibody (VNAb) response, and tumors were studied in commercial meat-type chickens...
  29. Qin A, Lee L, Fadly A, Hunt H, Cui Z. Development and characterization of monoclonal antibodies to subgroup J avian leukosis virus. Avian Dis. 2001;45:938-45 pubmed
    In an attempt to develop a specific diagnostic test for avian leukosis virus (ALV) subgroup J (ALV-J) strain Hc1, four monoclonal antibodies (MAbs), JE9, G2, 145, and J47, were generated that are specific for ALV-J envelope glycoprotein, ..
  30. Stepanets V, Vernerova Z, Vilhelmová M, Geryk J, Plachy J, Hejnar J, et al. Intraembryonic avian leukosis virus subgroup C (ALV-C) inoculation producing wasting disease in ducks soon after hatching. Folia Biol (Praha). 2003;49:100-9 pubmed
    ..On the basis of these and additional observations we propose that inoculation of duck embryos provides a suitable model for analysis of the wasting disease produced by ALV-C...
  31. Williams S, Reed W, Bacon L, Fadly A. Response of white leghorn chickens of various genetic lines to infection with avian leukosis virus subgroup J. Avian Dis. 2004;48:61-7 pubmed
    ..chickens from various white leghorn experimental lines were inoculated with strain ADOL-Hcl of subgroup J avian leukosis virus (ALV-J) either as embryos or at 1 day of age...
  32. Hatai H, Ochiai K, Umemura T. Detection of Avian leukosis virus genome by a nested polymerase chain reaction using DNA and RNA from dried feather shafts. J Vet Diagn Invest. 2009;21:519-22 pubmed
    ..using frozen feather pulp is useful for detecting fowl glioma-inducing virus (FGV), which belongs to the Avian leukosis virus family, and it has recently been suggested that FGV has spread to ornamental chickens kept in Japanese ..
  33. Chesters P, Howes K, Petherbridge L, Evans S, Payne L, Venugopal K. The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively. J Gen Virol. 2002;83:2553-61 pubmed
    Among the six envelope subgroups of avian leukosis virus (ALV) that infect chickens, subgroups A (ALV-A) and J (ALV-J) are the most pathogenic and widespread among commercial chicken populations...
  34. Diaz Griffero F, Hoschander S, BROJATSCH J. Bystander killing during avian leukosis virus subgroup B infection requires TVB(S3) signaling. J Virol. 2003;77:12552-61 pubmed
    Cell killing by avian leukosis virus subgroup B (ALV-B) in cultures has been extensively studied, but the molecular basis of this process has not been established...
  35. Barnard R, Narayan S, Dornadula G, Miller M, Young J. Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral uncoating. J Virol. 2004;78:10433-41 pubmed
    ..These studies provide strong support for the model, indicating that low pH is required for ASLV Env-dependent viral penetration into the cytosol and not for viral uncoating...
  36. Bacon L, Fulton J, Kulkarni G. Methods for evaluating and developing commercial chicken strains free of endogenous subgroup E avian leukosis virus. Avian Pathol. 2004;33:233-43 pubmed
    The genome of nearly all chickens contains various DNA proviral insertions of retroviruses of subgroup E avian leukosis virus (ALVE)...
  37. Johnson J, Heneine W. Characterization of endogenous avian leukosis viruses in chicken embryonic fibroblast substrates used in production of measles and mumps vaccines. J Virol. 2001;75:3605-12 pubmed
    ..Our data demonstrate that both defective and nondefective ev loci can be present in CEF vaccine substrates and suggest that both ev classes may contribute to the ALV present in vaccines...
  38. Hunt H, Lee L, Foster D, Silva R, Fadly A. A genetically engineered cell line resistant to subgroup J avian leukosis virus infection (C/J). Virology. 1999;264:205-10 pubmed
    A cell line (DF-1¿J) expressing the envelope protein isolated from the ADOL-Hc1 strain of the avian leukosis virus subgroup J (ALV-J) was used to analyze receptor interference to six different isolates of ALV-J as well as ALV subgroups A-..
  39. Li H, Ji J, Xie Q, Shang H, Zhang H, Xin X, et al. Aberrant expression of liver microRNA in chickens infected with subgroup J avian leukosis virus. Virus Res. 2012;169:268-71 pubmed publisher
    Subgroup J avian leukosis virus (ALV-J) is an oncogenic retrovirus primarily causing myeloid leukosis (ML) in broilers...
  40. Hatai H, Ochiai K, Nagakura K, Imanishi S, Ochi A, Kozakura R, et al. A recombinant avian leukosis virus associated with fowl glioma in layer chickens in Japan. Avian Pathol. 2008;37:127-37 pubmed publisher
    ..is characterized by multiple nodular growth of astrocytes, and fowl glioma-inducing virus belonging to avian leukosis virus has been isolated from Japanese bantam as a causal agent...
  41. Zavala G, Cheng S, Jackwood M. Molecular epidemiology of avian leukosis virus subgroup J and evolutionary history of its 3' untranslated region. Avian Dis. 2007;51:942-53 pubmed
    ..Some of the mutations in the 3' UTR have resulted in the emergence of moderately distinct genetic lineages representing each primary breeding company from which ALV-J was isolated...
  42. Yang F, Xian R, Li Y, Polony T, Beemon K. Telomerase reverse transcriptase expression elevated by avian leukosis virus integration in B cell lymphomas. Proc Natl Acad Sci U S A. 2007;104:18952-7 pubmed
    ..In this study, we identified avian leukosis virus (ALV) proviral integration sites in rapid-onset B cell lymphomas arising <12 weeks after infection of ..
  43. Payne L, Brown S, Bumstead N, Howes K, Frazier J, Thouless M. A novel subgroup of exogenous avian leukosis virus in chickens. J Gen Virol. 1991;72 ( Pt 4):801-7 pubmed
    An avian leukosis virus with a wide host range belonging to a new subgroup for chickens was isolated from meat-type chicken lines...
  44. Chai N, Bates P. Na+/H+ exchanger type 1 is a receptor for pathogenic subgroup J avian leukosis virus. Proc Natl Acad Sci U S A. 2006;103:5531-6 pubmed
    Subgroup J avian leukosis virus (ALV-J) is a recently identified avian oncogenic retrovirus responsible for severe economic losses worldwide...
  45. Mays J, Bacon L, Pandiri A, Fadly A. Response of white leghorn chickens of various B haplotypes to infection at hatch with subgroup J avian leukosis virus. Avian Dis. 2005;49:214-9 pubmed
    ..B semicongenic lines were infected at hatch with strain ADOL Hc-1 of subgroup J avian leukosis virus (ALV-J)...
  46. Lehmann M, Sherer N, Marks C, Pypaert M, Mothes W. Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells. J Cell Biol. 2005;170:317-25 pubmed
    ..Our results reveal another example of viruses hijacking host machineries for efficient infection by using the inherent ability of filopodia to transport ligands to the cell body...
  47. Wang Q, Gao Y, Ji X, Qi X, Qin L, Gao H, et al. Differential expression of microRNAs in avian leukosis virus subgroup J-induced tumors. Vet Microbiol. 2013;162:232-8 pubmed publisher
    b>Avian leukosis virus subgroup J (ALV-J) has become pandemic and induced serious clinical outbreaks in chickens in China...
  48. Boyce Jacino M, O Donoghue K, Faras A. Multiple complex families of endogenous retroviruses are highly conserved in the genus Gallus. J Virol. 1992;66:4919-29 pubmed
  49. Gao Y, Yun B, Qin L, Pan W, Qu Y, Liu Z, et al. Molecular epidemiology of avian leukosis virus subgroup J in layer flocks in China. J Clin Microbiol. 2012;50:953-60 pubmed publisher
    b>Avian leukosis virus subgroup J (ALV-J) was first isolated from meat-type chickens in 1988. No field cases of ALV-J infection or tumors in layer chickens were observed worldwide until 2004...
  50. Melikyan G, Barnard R, Markosyan R, Young J, Cohen F. Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growth. J Virol. 2004;78:3753-62 pubmed
    ..At this point, but not before, low pH can induce fusion and is in fact required for fusion to occur. However, low pH is no longer necessary after formation of the initial fusion pore: pore enlargement does not require low pH...
  51. Benkel B. Locus-specific diagnostic tests for endogenous avian leukosis-type viral loci in chickens. Poult Sci. 1998;77:1027-35 pubmed
    ..In addition, it compares the insertion sites of these elements in an effort to identify common motifs at ALVE integration sites...
  52. Zavala G, Jackwood M, Hilt D. Polymerase chain reaction for detection of avian leukosis virus subgroup J in feather pulp. Avian Dis. 2002;46:971-8 pubmed
    ..infected chickens was used as a source of DNA for polymerase chain reaction (PCR) amplification of avian leukosis virus subgroup J (ALV-J) proviral DNA...
  53. Hussain A, Shanmugam V, Switzer W, Tsang S, Fadly A, Thea D, et al. Lack of evidence of endogenous avian leukosis virus and endogenous avian retrovirus transmission to measles, mumps, and rubella vaccine recipients. Emerg Infect Dis. 2001;7:66-72 pubmed
    The identification of endogenous avian leukosis virus (ALV) and endogenous avian retrovirus (EAV) in chick cell-derived measles and mumps vaccines in current use has raised concern about transmission of these retroviruses to vaccine ..
  54. Mays J, Pandiri A, Fadly A. Susceptibility of various parental lines of commercial white leghorn layers to infection with a naturally occurring recombinant avian leukosis virus containing subgroup B envelope and subgroup J long terminal repeat. Avian Dis. 2006;50:342-7 pubmed
    ..White Leghorn layer flocks from three independent breeders were inoculated with a naturally occurring avian leukosis virus (ALV) containing an ALV-B envelope and an ALV-J long terminal repeat (LTR) termed ALV-B/J...
  55. Bates P, Rong L, Varmus H, Young J, Crittenden L. Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus. J Virol. 1998;72:2505-8 pubmed
    ..However, analysis of the genomic sequence encoding this region of Tva in randomly bred chickens suggests that the altered virus binding domain is not the basis for genetic resistance in the chicken lines analyzed...
  56. Wang F, Wang X, Chen H, Liu J, Cheng Z. The critical time of avian leukosis virus subgroup J-mediated immunosuppression during early stage infection in specific pathogen-free chickens. J Vet Sci. 2011;12:235-41 pubmed
    The critical time of avian leukosis virus subgroup J (ALV-J)-mediated immunosuppression was determined by body weight, relative immune organ weight, histopathology, and presence of group specific antigen and antibodies in specific ..
  57. Ochsenbauer Jambor C, Delos S, Accavitti M, White J, Hunter E. Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex. J Virol. 2002;76:7518-27 pubmed
    ..Thus, anti-ASLV-SU-A mc8C5-4 proves to be a unique new immunoreagent that targets the receptor-binding site on a prototypical retroviral envelope...
  58. Stedman N, Brown T. Cardiomyopathy in broiler chickens congenitally infected with avian leukosis virus subgroup J. Vet Pathol. 2002;39:161-4 pubmed
    ..are frequently associated with rapid growth and pulmonary hypertension, but can be associated with some avian leukosis virus (ALV) infections...
  59. Davidson I, Borenshtain R. The feather tips of commercial chickens are a favorable source of DNA for the amplification of Marek's disease virus and avian leukosis virus, subgroup J. Avian Pathol. 2002;31:237-40 pubmed
    Marek's disease virus (MDV), a herpesvirus, and avian leukosis virus, subgroup J (ALV-J), a retrovirus, are oncogenic viruses of poultry...
  60. Cui Z, Du Y, Zhang Z, Silva R. Comparison of Chinese field strains of avian leukosis subgroup J viruses with prototype strain HPRS-103 and United States strains. Avian Dis. 2003;47:1321-30 pubmed
    ..The result implies that envelope gp85 may not have diverged from prototype and older strains. It is also possible that some recently imported birds could have been infected by the older viruses that were introduced in the late 1990s...
  61. Sacco M, Howes K, Smith L, Nair V. Assessing the roles of endogenous retrovirus EAV-HP in avian leukosis virus subgroup J emergence and tolerance. J Virol. 2004;78:10525-35 pubmed
    b>Avian leukosis virus (ALV) subgroup J is thought to have emerged through a recombination event between an unknown exogenous ALV and the endogenous retrovirus elements designated EAV-HP...
  62. Maas R, van Zoelen D, Oei H, Claassen I. Replacement of primary chicken embryonic fibroblasts (CEF) by the DF-1 cell line for detection of avian leucosis viruses. Biologicals. 2006;34:177-81 pubmed
    ..For reasons of sensitivity, standardisation as well as reduction of animal use, the data support the use of DF-1 cells to monitor absence of ALV in vaccine virus seed lots or finished products...
  63. Davidson I, Borenshtain R, Kung H, Witter R. Molecular indications for in vivo integration of the avian leukosis virus, subgroup J-long terminal repeat into the Marek's disease virus in experimentally dually-infected chickens. Virus Genes. 2002;24:173-80 pubmed
    Marek's disease virus, a herpesvirus, and avian leukosis virus, subgroup J, a retrovirus, are oncogenic viruses of poultry. Both viruses may infect the same flock, the same bird and the same cell...
  64. Smith J, Mothes W, Blacklow S, Cunningham J. The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol. 2004;78:1403-10 pubmed
    ..As a test of this hypothesis, the requirements for avian leukosis virus A (ALV-A) infection were examined...
  65. Thapa B, Omar A, Arshad S, Hair Bejo M. Detection of avian leukosis virus subgroup J in chicken flocks from Malaysia and their molecular characterization. Avian Pathol. 2004;33:359-63 pubmed
    Previously we have shown that avian leukosis virus subgroup J (ALV-J) might be present in chicken flocks from Malaysia based on serological study and also on detection of tissue samples with myelocytic infiltration...
  66. Nilsen T, Maroney P, Goodwin R, Rottman F, Crittenden L, Raines M, et al. c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. Cell. 1985;41:719-26 pubmed
    ..These results establish a novel pathway of promoter insertion oncogenesis that stands in contrast to the pathways used in the activation of c-myc in B lymphomas...
  67. Lupiani B, Pandiri A, Mays J, Hunt H, Fadly A. Molecular and biological characterization of a naturally occurring recombinant subgroup B avian leukosis virus with a subgroup J-like long terminal repeat. Avian Dis. 2006;50:572-8 pubmed
    Infection of broiler chickens with subgroup J avian leukosis virus (ALV) results in the induction of myeloid tumors...
  68. Kucerova D, Plachy J, Reinisová M, Senigl F, Trejbalova K, Geryk J, et al. Nonconserved tryptophan 38 of the cell surface receptor for subgroup J avian leukosis virus discriminates sensitive from resistant avian species. J Virol. 2013;87:8399-407 pubmed publisher
    Subgroup J avian leukosis virus (ALV-J) is unique among the avian sarcoma and leukosis viruses in using the multimembrane-spanning cell surface protein Na(+)/H(+) exchanger type 1 (NHE1) as a receptor...
  69. Snitkovsky S, Niederman T, Mulligan R, Young J. Targeting avian leukosis virus subgroup A vectors by using a TVA-VEGF bridge protein. J Virol. 2001;75:1571-5 pubmed
    Previously, we have demonstrated that bridge proteins comprised of avian leukosis virus (ALV) receptors fused to epidermal growth factor (EGF) can be used to selectively target retroviral vectors with ALV envelope proteins to cells ..