hepatitis e virus

Summary

Summary: A positive-stranded RNA virus species in the genus HEPEVIRUS, causing enterically-transmitted non-A, non-B hepatitis (HEPATITIS E).

Top Publications

  1. Rein D, Stevens G, Theaker J, Wittenborn J, Wiersma S. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology. 2012;55:988-97 pubmed publisher
    We estimated the global burden of hepatitis E virus (HEV) genotypes 1 and 2 in 2005...
  2. Wilhelm B, Rajic A, Greig J, Waddell L, Trottier G, Houde A, et al. A systematic review/meta-analysis of primary research investigating swine, pork or pork products as a source of zoonotic hepatitis E virus. Epidemiol Infect. 2011;139:1127-44 pubmed publisher
    ..our study were to identify and categorize primary research investigating swine/pork as a source of zoonotic hepatitis E virus (HEV) using the relatively new technique of scoping study, and to investigate the potential association ..
  3. Namsai A, Louisirirotchanakul S, Wongchinda N, Siripanyaphinyo U, Virulhakul P, Puthavathana P, et al. Surveillance of hepatitis A and E viruses contamination in shellfish in Thailand. Lett Appl Microbiol. 2011;53:608-13 pubmed publisher
    To survey for hepatitis A virus (HAV) and hepatitis E virus (HEV) contamination in edible bivalve shellfish.
  4. Vernier M, Rossi Tamisier M, Richet H, Brouqui P, Parola P, Bouamri Y, et al. Anti-hepatitis E virus antibody prevalence in French expatriate workers. Int J Infect Dis. 2013;17:e1082-4 pubmed publisher
    The hepatitis E virus (HEV) is a leading cause of acute hepatitis in developing countries and an emerging pathogen in Europe...
  5. Riezebos Brilman A, Verschuuren E, van Son W, van Imhoff G, Brügemann J, Blokzijl H, et al. The clinical course of hepatitis E virus infection in patients of a tertiary Dutch hospital over a 5-year period. J Clin Virol. 2013;58:509-14 pubmed publisher
    b>Hepatitis E virus (HEV) has long been known as a major cause of acute hepatitis in developing countries with occasional travel-related cases in developed countries, most of them belonging to genotype 1...
  6. Goyal R, Kumar A, Panda S, Paul S, Acharya S. Ribavirin therapy for hepatitis E virus-induced acute on chronic liver failure: a preliminary report. Antivir Ther. 2012;17:1091-6 pubmed publisher
    b>Hepatitis E virus (HEV) is a common cause of acute on chronic liver failure (ACLF) in HEV hyperendemic regions with high mortality. Treatment for HEV-induced ACLF is currently not available...
  7. Dalton H, Bendall R, Rashid M, Ellis V, Ali R, Ramnarace R, et al. Host risk factors and autochthonous hepatitis E infection. Eur J Gastroenterol Hepatol. 2011;23:1200-5 pubmed publisher
    In developed countries autochthonous hepatitis E infection is caused by hepatitis E virus (HEV) genotype 3 or 4 and mainly affects middle aged/elderly men. Host factors might explain why older men develop clinically overt disease...
  8. Xu C, Wang R, Schechterly C, Ge S, Shih J, Xia N, et al. An assessment of hepatitis E virus (HEV) in US blood donors and recipients: no detectable HEV RNA in 1939 donors tested and no evidence for HEV transmission to 362 prospectively followed recipients. Transfusion. 2013;53:2505-11 pubmed publisher
    b>Hepatitis E virus (HEV) infection has become relevant to blood transfusion practice because isolated cases of blood transmission have been reported and because HEV has been found to cause chronic infection and severe liver disease in ..
  9. Versluis J, Pas S, Agteresch H, de Man R, Maaskant J, Schipper M, et al. Hepatitis E virus: an underestimated opportunistic pathogen in recipients of allogeneic hematopoietic stem cell transplantation. Blood. 2013;122:1079-86 pubmed publisher
    b>Hepatitis E virus (HEV) is increasingly acknowledged as a cause of hepatitis in healthy individuals as well as immunocompromised patients...

More Information

Publications139 found, 100 shown here

  1. Wang S, Cheng X, Dai X, Dong C, Xu M, Liang J, et al. Rabbit and human hepatitis E virus strains belong to a single serotype. Virus Res. 2013;176:101-6 pubmed publisher
    b>Hepatitis E virus (HEV) is a zoonotic pathogen and all four established genotypes of HEV belong to a single serotype. The recently identified rabbit HEV is antigenically and genetically related to human HEV...
  2. Yang D, Jiang M, Jin M, Qiu Z, Cui W, Shen Z, et al. Full-length sequence analysis of hepatitis E virus isolates: showing potential determinants of virus genotype and identity. Virus Genes. 2013;47:414-21 pubmed publisher
    The complete genome sequence of a genotype 4 strain of hepatitis E virus (CH-YT-HEV02) from a patient (in Yantai, China) has been determined. Phylogenetic analysis showed that CH-YT-HEV02 belongs to genotype 4, subtype 4a...
  3. Osterman A, Vizoso Pinto M, Jung J, Jaeger G, Eberle J, Nitschko H, et al. A novel indirect immunofluorescence test for the detection of IgG and IgA antibodies for diagnosis of Hepatitis E Virus infections. J Virol Methods. 2013;191:48-54 pubmed publisher
    b>Hepatitis E Virus (HEV) causes epidemic infections in regions of poor hygiene in the developing world...
  4. Wacheck S, Werres C, Mohn U, Dorn S, Soutschek E, Fredriksson Ahomaa M, et al. Detection of IgM and IgG against hepatitis E virus in serum and meat juice samples from pigs at slaughter in Bavaria, Germany. Foodborne Pathog Dis. 2012;9:655-60 pubmed publisher
    b>Hepatitis E virus (HEV) is an emerging foodborne pathogen with domestic and wild pigs (and likely other species such as deer or rabbits) recognized as reservoir. Pathogenesis in pigs usually leads to an asymptomatic course of disease...
  5. Chen X, Zhang Q, He C, Zhang L, Li J, Zhang W, et al. Recombination and natural selection in hepatitis E virus genotypes. J Med Virol. 2012;84:1396-407 pubmed publisher
    To gain new insights into the evolutionary processes that created the genetic diversity of the hepatitis E virus (HEV), the Recombination Detection Program (RDP) and SimPlot program were employed to detect recombination events in the ..
  6. Moal V, Gerolami R, Colson P. First human case of co-infection with two different subtypes of hepatitis E virus. Intervirology. 2012;55:484-7 pubmed publisher
    b>Hepatitis E virus (HEV), the main etiologic agent of enterically transmitted acute hepatitis in developing countries, is now recognized as an emerging agent of autochthonous disease and chronic hepatitis E in immunocompromised patients ..
  7. Wedemeyer H, Pischke S, Manns M. Pathogenesis and treatment of hepatitis e virus infection. Gastroenterology. 2012;142:1388-1397.e1 pubmed publisher
    ..However, hepatitis E virus (HEV) infection can also be acquired in industrialized countries-HEV genotype 3 infection is a zoonosis, ..
  8. Barnaud E, Rogée S, Garry P, Rose N, Pavio N. Thermal inactivation of infectious hepatitis E virus in experimentally contaminated food. Appl Environ Microbiol. 2012;78:5153-9 pubmed publisher
    b>Hepatitis E virus (HEV) infection of zoonotic origin is an emerging concern in industrialized countries...
  9. Zwettler D, Fink M, Revilla Fernández S, Steinrigl A, Winter P, Kofer J. First detection of hepatitis E virus in Austrian pigs by RT-qPCR. Berl Munch Tierarztl Wochenschr. 2012;125:281-9 pubmed
    ..For specificity testing several common swine pathogens were used. Results demonstrated that the proposed method allows implementation of reliable high-throughput screening of Austrian swine samples in the future. ..
  10. Zhang H, Chen D, Wu Y, He Q, Chen H, Liu Z. Both swine and human cells are capable to support the replication of swine hepatitis E virus type 4 in vitro. Virus Res. 2011;158:289-93 pubmed publisher
    Using swine anal swab or liver as inocula, cell-culture systems were developed for swine hepatitis E virus (HEV) in swine cells (IBRS-2) and human cells (A549)...
  11. Chandra V, Holla P, Ghosh D, Chakrabarti D, Padigaru M, Jameel S. The hepatitis E virus ORF3 protein regulates the expression of liver-specific genes by modulating localization of hepatocyte nuclear factor 4. PLoS ONE. 2011;6:e22412 pubmed publisher
    The hepatitis E virus (HEV) is a small RNA virus and the cause of acute viral hepatitis E...
  12. Dremsek P, Wenzel J, Johne R, Ziller M, Hofmann J, Groschup M, et al. Seroprevalence study in forestry workers from eastern Germany using novel genotype 3- and rat hepatitis E virus-specific immunoglobulin G ELISAs. Med Microbiol Immunol. 2012;201:189-200 pubmed publisher
    b>Hepatitis E virus (HEV) is the causative agent of an acute self-limiting hepatitis in humans. In industrialized countries, autochthonous cases are linked to zoonotic transmission from domestic pigs, wild boar and red deer...
  13. García C, Sánchez D, Villalba M, Pujol F, de Los Ángeles Rodríguez Lay L, Pinto B, et al. Molecular characterization of hepatitis E virus in patients with acute hepatitis in Venezuela. J Med Virol. 2012;84:1025-9 pubmed publisher
    b>Hepatitis E virus (HEV) causes a common infection in developing countries. HEV infection occurs as outbreaks, as sporadic clinical cases and as large epidemics in endemic areas...
  14. Izopet J, Dubois M, Bertagnoli S, Lhomme S, Marchandeau S, Boucher S, et al. Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France. Emerg Infect Dis. 2012;18:1274-81 pubmed publisher
    b>Hepatitis E virus (HEV) strains from rabbits indicate that these mammals may be a reservoir for HEVs that cause infection in humans...
  15. Maylin S, Stephan R, Molina J, Peraldi M, Scieux C, Nicand E, et al. Prevalence of antibodies and RNA genome of hepatitis E virus in a cohort of French immunocompromised. J Clin Virol. 2012;53:346-9 pubmed publisher
    ..and 46 kidney transplant (KT)-patients were retrospectively tested for the presence of the following hepatitis E virus (HEV) infection markers: anti-HEV IgM antibodies, anti-HEV IgG antibodies, anti-HEV IgG avidity index, and ..
  16. Houcine N, Jacques R, Salma F, Anne Gaëlle D, Amin S, Mohsen H, et al. Seroprevalence of hepatitis E virus infection in rural and urban populations, Tunisia. Clin Microbiol Infect. 2012;18:E119-21 pubmed publisher
    b>Hepatitis E virus (HEV) is one of the leading agents of acute hepatitis...
  17. de la Caridad Montalvo Villalba M, Owot J, Benedito E, Corrreia B, Corredor M, Flaquet P, et al. Hepatitis E virus genotype 3 in humans and swine, Cuba. Infect Genet Evol. 2013;14:335-9 pubmed publisher
    This study was conduced to determinate the seroprevalence and risk factors associated to hepatitis E virus (HEV) exposition, in individuals who work in pig farms located at western of Artemise Province...
  18. Li T, Ochiai S, Ishiko H, Wakita T, Miyamura T, Takeda N. A retrospective study on imported hepatitis E in Japan. Travel Med Infect Dis. 2012;10:80-5 pubmed publisher
    b>Hepatitis E virus (HEV), a causative agent of human hepatitis E, is transmitted through an oral-fecal route, often by contaminated drinking water...
  19. Cossaboom C, Córdoba L, Sanford B, Piñeyro P, Kenney S, Dryman B, et al. Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States. J Gen Virol. 2012;93:1687-95 pubmed publisher
    b>Hepatitis E virus (HEV) is an important human pathogen. In addition to humans, HEV has also been identified in pig, chicken, mongoose, deer, rat, rabbit and fish. There are four recognized and two putative genotypes of mammalian HEV...
  20. Seo D, Tahk H, Lee K, Lee M, Son N, Seo S, et al. Detecting hepatitis E virus with a reverse transcription polymerase chain reaction enzyme-linked immunosorbent assay. Food Environ Virol. 2012;4:14-20 pubmed publisher
    ..transcription polymerase chain reaction enzyme-linked immunosorbent assay (RT-PCR-ELISA) for detecting hepatitis E virus (HEV)...
  21. Park H, Jeong S, Kim J, Woo B, Lee D, Kim H, et al. Seroprevalence of anti-hepatitis E virus (HEV) in a Korean population: comparison of two commercial anti-HEV assays. BMC Infect Dis. 2012;12:142 pubmed
    b>Hepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute viral hepatitis worldwide...
  22. Emerson S, Nguyen H, Torian U, Mather K, Firth A. An essential RNA element resides in a central region of hepatitis E virus ORF2. J Gen Virol. 2013;94:1468-76 pubmed publisher
    b>Hepatitis E virus (genus Hepevirus, family Hepeviridae) is one of the most important causes of acute hepatitis in adults, particularly among pregnant women, throughout Asia and Africa where mortality rates can be 20-30 %...
  23. Wedemeyer H, Rybczynska J, Pischke S, Krawczynski K. Immunopathogenesis of hepatitis E virus infection. Semin Liver Dis. 2013;33:71-8 pubmed publisher
    The course of hepatitis E virus infection (HEV) can vary substantially between different individuals...
  24. Purcell R, Engle R, Rood M, Kabrane Lazizi Y, Nguyen H, Govindarajan S, et al. Hepatitis E virus in rats, Los Angeles, California, USA. Emerg Infect Dis. 2011;17:2216-22 pubmed publisher
    The role of rats in human hepatitis E virus (HEV) infections remains controversial. A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced...
  25. Faber M, Wenzel J, Jilg W, Thamm M, Höhle M, Stark K. Hepatitis E virus seroprevalence among adults, Germany. Emerg Infect Dis. 2012;18:1654-7 pubmed publisher
    We assessed hepatitis E virus (HEV) antibody seroprevalence in a sample of the adult population in Germany. Overall HEV IgG prevalence was 16.8% (95% CI 15.6%-17.9%) and increased with age, leveling off at >60 years of age...
  26. Tohme R, Drobeniuc J, Sanchez R, Heseltine G, Alsip B, Kamili S, et al. Acute hepatitis associated with autochthonous hepatitis E virus infection--San Antonio, Texas, 2009. Clin Infect Dis. 2011;53:793-6 pubmed publisher
    ..We report 2 cases of autochthonous acute hepatitis E in the United States. Hepatitis E virus genotype 3a related to US-2 and swine hepatitis E virus strains was isolated from one of the patients, ..
  27. Cleland A, Smith L, Crossan C, Blatchford O, Dalton H, Scobie L, et al. Hepatitis E virus in Scottish blood donors. Vox Sang. 2013;105:283-9 pubmed publisher
    Published prevalence figures for hepatitis E virus (HEV) reveal significant regional differences. Several studies have reported virus transmission via blood transfusion...
  28. Keane F, Gompels M, Bendall R, Drayton R, Jennings L, Black J, et al. Hepatitis E virus coinfection in patients with HIV infection. HIV Med. 2012;13:83-8 pubmed publisher
    b>Hepatitis E virus (HEV) infection is an emerging infection in developed countries and is thought to be a porcine zoonosis. HEV can cause chronic infection and cirrhosis in the immunosuppressed, including patients with HIV infection...
  29. Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, et al. Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions. J Gen Virol. 2011;92:2838-48 pubmed publisher
    ..an intact PSAP motif in the ORF3 protein is required for the formation and release of membrane-associated hepatitis E virus (HEV) particles with ORF3 proteins on their surface...
  30. Kaufmann A, Kenfak Foguena A, André C, Canellini G, Burgisser P, Moradpour D, et al. Hepatitis E virus seroprevalence among blood donors in southwest Switzerland. PLoS ONE. 2011;6:e21150 pubmed publisher
    The aim of this study was to determine the seroprevalence of Hepatitis E virus (HEV) among blood donors in southwest Switzerland. HEV is recognized as a food-borne disease in industrialized countries, transmitted mainly through pork meat...
  31. Silva S, Oliveira J, Vitral C, Vieira K, Pinto M, Souto F. Prevalence of hepatitis E virus antibodies in individuals exposed to swine in Mato Grosso, Brazil. Mem Inst Oswaldo Cruz. 2012;107:338-41 pubmed
    ..This prevalence did not characterise this type of exposure as a risk factor for HEV infection in this region. ..
  32. Devhare P, Chatterjee S, Arankalle V, Lole K. Analysis of antiviral response in human epithelial cells infected with hepatitis E virus. PLoS ONE. 2013;8:e63793 pubmed publisher
    b>Hepatitis E virus (HEV) is a major cause of enterically transmitted acute hepatitis in developing nations and occurs in sporadic and epidemic forms. The disease may become severe with high mortality (20%) among pregnant women...
  33. di Bartolo I, Diez Valcarce M, Vasickova P, Kralik P, Hernandez M, Angeloni G, et al. Hepatitis E virus in pork production chain in Czech Republic, Italy, and Spain, 2010. Emerg Infect Dis. 2012;18:1282-9 pubmed publisher
    We evaluated the prevalence of hepatitis E virus (HEV) in the pork production chain in Czech Republic, Italy, and Spain during 2010...
  34. Mori Y, Matsuura Y. Structure of hepatitis E viral particle. Virus Res. 2011;161:59-64 pubmed publisher
    Hepatitis E is acute hepatitis caused by infection of hepatitis E virus (HEV) via a fecal-to-oral or zoonotic route. HEV is a small, non-enveloped virus containing positive strand RNA as a genome...
  35. Carpentier A, Chaussade H, Rigaud E, Rodriguez J, Berthault C, Boue F, et al. High hepatitis E virus seroprevalence in forestry workers and in wild boars in France. J Clin Microbiol. 2012;50:2888-93 pubmed publisher
    b>Hepatitis E virus (HEV) is a fecally and orally transmitted human pathogen of worldwide distribution. In industrial countries, HEV is observed in an increasing number of autochthonous cases and is considered to be an emerging pathogen...
  36. Caron M, Bouscaillou J, Kazanji M. Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa. Virol J. 2012;9:254 pubmed publisher
    b>Hepatitis E virus (HEV), an enterically transmitted pathogen, is highly endemic in several African countries. Pregnant women are at particularly high risk for acute or severe hepatitis E...
  37. Garbuglia A, Scognamiglio P, Petrosillo N, Mastroianni C, Sordillo P, Gentile D, et al. Hepatitis E virus genotype 4 outbreak, Italy, 2011. Emerg Infect Dis. 2013;19:110-4 pubmed publisher
    During 2011, 5 persons in the area of Lazio, Italy were infected with a monophyletic strain of hepatitis E virus that showed high sequence homology with isolates from swine in China...
  38. Yugo D, Meng X. Hepatitis E virus: foodborne, waterborne and zoonotic transmission. Int J Environ Res Public Health. 2013;10:4507-33 pubmed publisher
    b>Hepatitis E virus (HEV) is responsible for epidemics and endemics of acute hepatitis in humans, mainly through waterborne, foodborne, and zoonotic transmission routes...
  39. Sellier P, Mazeron M, Tesse S, Badsi E, Evans J, Magnier J, et al. Hepatitis E virus infection in HIV-infected patients with elevated serum transaminases levels. Virol J. 2011;8:171 pubmed publisher
    ..HIV-infected patients with elevated aminotransferases levels were retrospectively tested for the presence of hepatitis E virus (HEV) infection markers: anti-HEV IgM antibodies, anti-HEV IgG antibodies, anti-HEV IgG avidity index and ..
  40. Schlosser B, Stein A, Neuhaus R, Pahl S, Ramez B, Kruger D, et al. Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient. J Hepatol. 2012;56:500-2 pubmed publisher
    Acute hepatitis E virus (HEV) infection is a self-limiting symptomatic or asymptomatic disease...
  41. Drexler J, Seelen A, Corman V, Fumie Tateno A, Cottontail V, Melim Zerbinati R, et al. Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae. J Virol. 2012;86:9134-47 pubmed publisher
    b>Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis in tropical and temperate climates. Tropical genotypes 1 and 2 are associated with food-borne and waterborne transmission...
  42. Bouquet J, Cherel P, Pavio N. Genetic characterization and codon usage bias of full-length Hepatitis E virus sequences shed new lights on genotypic distribution, host restriction and genome evolution. Infect Genet Evol. 2012;12:1842-53 pubmed publisher
    b>Hepatitis E virus (HEV) is present in different species and ecological niches. It has been divided into 4 major mammalian genotypes...
  43. Kumar S, Subhadra S, Singh B, Panda B. Hepatitis E virus: the current scenario. Int J Infect Dis. 2013;17:e228-33 pubmed publisher
    Hepatitis E infection, caused by the hepatitis E virus (HEV), is a common cause of acute hepatitis in developing countries with poor sanitation and hygiene. The virus is classified into four genotypes (1-4) with one serotype...
  44. Goumba A, Konamna X, Komas N. Clinical and epidemiological aspects of a hepatitis E outbreak in Bangui, Central African Republic. BMC Infect Dis. 2011;11:93 pubmed publisher
    ..b>Hepatitis E virus (HEV) infections are usually accompanied by general symptoms of acute liver disease...
  45. Conlan J, Jarman R, Vongxay K, Chinnawirotpisan P, Melendrez M, Fenwick S, et al. Hepatitis E virus is prevalent in the pig population of Lao People's Democratic Republic and evidence exists for homogeneity with Chinese Genotype 4 human isolates. Infect Genet Evol. 2011;11:1306-11 pubmed publisher
    The objective of this study was to determine the prevalence and genotypic range of Hepatitis E virus (HEV) in the pig population of northern Lao People's Democratic Republic (PDR)...
  46. Chatterjee S, Devhare P, Lole K. Detection of negative-sense RNA in packaged hepatitis E virions by use of an improved strand-specific reverse transcription-PCR method. J Clin Microbiol. 2012;50:1467-70 pubmed publisher
    Current hepatitis E virus (HEV) negative-sense RNA detection assays have the drawback of false positivity. cDNA synthesis using tag-based primer and Superscript RT-III followed by exonuclease I treatment increased the specificity...
  47. Pas S, de Man R, Mulders C, Balk A, van Hal P, Weimar W, et al. Hepatitis E virus infection among solid organ transplant recipients, the Netherlands. Emerg Infect Dis. 2012;18:869-72 pubmed publisher
    We screened 1,200 living heart, lung, liver, and kidney transplant recipients for hepatitis E virus infection by reverse transcription PCR...
  48. Smith D, Vanek J, Ramalingam S, Johannessen I, Templeton K, Simmonds P. Evolution of the hepatitis E virus hypervariable region. J Gen Virol. 2012;93:2408-18 pubmed publisher
    The presence of a hypervariable (HVR) region within the genome of hepatitis E virus (HEV) remains unexplained. Previous studies have described the HVR as a proline-rich spacer between flanking functional domains of the ORF1 polyprotein...
  49. Li W, Guan D, Su J, Takeda N, Wakita T, Li T, et al. High prevalence of rat hepatitis E virus in wild rats in China. Vet Microbiol. 2013;165:275-80 pubmed publisher
    ..in Zhanjiang city in China from December 2011 to September 2012 were investigated for the prevalence of rat hepatitis E virus (HEV) by exploring rat HEV-specific antibodies and RNA...
  50. Aggarwal R, Jameel S. Hepatitis E. Hepatology. 2011;54:2218-26 pubmed publisher
    Hepatitis E refers to liver disease caused by the hepatitis E virus (HEV), a small, nonenveloped virus with a single-stranded RNA genome. The virus has four genotypes, but only one serotype...
  51. Liu P, Li L, Wang L, Bu Q, Fu H, Han J, et al. Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission. Infect Genet Evol. 2012;12:428-34 pubmed publisher
    ..To determine the overall molecular epidemiology of hepatitis E virus (HEV) and analyze the situation of cross-species transmission between humans and swine in China over the ..
  52. Shukla P, Nguyen H, Faulk K, Mather K, Torian U, Engle R, et al. Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination. J Virol. 2012;86:5697-707 pubmed publisher
    An infectious cDNA clone of a genotype 3 strain of hepatitis E virus adapted to growth in HepG2/C3A human hepatoma cells was constructed...
  53. Brassard J, Gagné M, Généreux M, Côté C. Detection of human food-borne and zoonotic viruses on irrigated, field-grown strawberries. Appl Environ Microbiol. 2012;78:3763-6 pubmed publisher
    ..Norovirus genogroup I, rotavirus, and swine hepatitis E virus genogroup 3 were detected on strawberries, and irrigation water is suspected as the contamination origin.
  54. Bouquet J, Cheval J, Rogée S, Pavio N, Eloit M. Identical consensus sequence and conserved genomic polymorphism of hepatitis E virus during controlled interspecies transmission. J Virol. 2012;86:6238-45 pubmed publisher
    High-throughput sequencing of bile and feces from two pigs experimentally infected with human hepatitis E virus (HEV) of genotype 3f revealed the same full-length consensus sequence as in the human sample...
  55. Zhang J, Li S, Wu T, Zhao Q, Ng M, Xia N. Hepatitis E virus: neutralizing sites, diagnosis, and protective immunity. Rev Med Virol. 2012;22:339-49 pubmed publisher
    ..One of them has been licensed in China recently. However, many issues need to be resolved before new technological progresses can benefit the people who need them most. ..
  56. Berto A, Grierson S, Hakze van der Honing R, Martelli F, Johne R, Reetz J, et al. Hepatitis E virus in pork liver sausage, France. Emerg Infect Dis. 2013;19:264-6 pubmed publisher
    We investigated viability of hepatitis E virus (HEV) identified in contaminated pork liver sausages obtained from France. HEV replication was demonstrated in 1 of 4 samples by using a 3-dimensional cell culture system...
  57. Sasaki Y, Haruna M, Murakami M, Hayashida M, Ito K, Noda M, et al. Prevalence of Campylobacter spp., Salmonella spp., Listeria monocytogenes, and hepatitis E virus in swine livers collected at an abattoir. Jpn J Infect Dis. 2013;66:161-4 pubmed
    We investigated the prevalence of Campylobacter spp., Salmonella spp., Listeria monocytogenes, and hepatitis E virus (HEV) in swine liver...
  58. Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, et al. A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. Arch Virol. 2011;156:1345-58 pubmed publisher
    To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars (Sus scrofa leucomystax), 578 boars captured in 25 prefectures from 2003 to 2010 were studied...
  59. Tang X, Yang C, Gu Y, Song C, Zhang X, Wang Y, et al. Structural basis for the neutralization and genotype specificity of hepatitis E virus. Proc Natl Acad Sci U S A. 2011;108:10266-71 pubmed publisher
    b>Hepatitis E virus (HEV) causes acute hepatitis in humans, predominantly by contamination of food and water, and is characterized by jaundice and flu-like aches and pains...
  60. Cacciola I, Messineo F, Cacopardo B, Di Marco V, Galli C, Squadrito G, et al. Hepatitis E virus infection as a cause of acute hepatitis in Southern Italy. Dig Liver Dis. 2011;43:996-1000 pubmed publisher
    b>Hepatitis E virus (HEV) is a major cause of acute hepatitis in developing countries, whereas it is not considered a major health problem in Western World.
  61. Osterman A, Vizoso Pinto M, Haase R, Nitschko H, Jäger S, Sander M, et al. Systematic screening for novel, serologically reactive Hepatitis E Virus epitopes. Virol J. 2012;9:28 pubmed publisher
    The National Institutes of Health classified Hepatitis E as an emerging disease since Hepatitis E Virus (HEV) is the major cause of acute hepatitis in developing countries...
  62. Kamar N, Izopet J, Tripon S, Bismuth M, Hillaire S, Dumortier J, et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. N Engl J Med. 2014;370:1111-20 pubmed publisher
    There is no established therapy for hepatitis E virus (HEV) infection...
  63. Baylis S, Blümel J, Mizusawa S, Matsubayashi K, Sakata H, Okada Y, et al. World Health Organization International Standard to harmonize assays for detection of hepatitis E virus RNA. Emerg Infect Dis. 2013;19:729-35 pubmed publisher
    Nucleic acid amplification technique-based assays are a primary method for the detection of acute hepatitis E virus (HEV) infection, but assay sensitivity can vary widely...
  64. Sanford B, Dryman B, Huang Y, Feagins A, LeRoith T, Meng X. Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV. Virus Res. 2011;159:17-22 pubmed publisher
    b>Hepatitis E virus (HEV) is an important human pathogen. At least four recognized and two putative genotypes of mammalian HEV have been reported: genotypes 1 and 2 are restricted to humans whereas genotypes 3 and 4 are zoonotic...
  65. Cossaboom C, Córdoba L, Dryman B, Meng X. Hepatitis E virus in rabbits, Virginia, USA. Emerg Infect Dis. 2011;17:2047-9 pubmed publisher
    We identified hepatitis E virus (HEV) in rabbits in Virginia, USA. HEV RNA was detected in 14 (16%) of 85 serum samples and 13 (15%) of 85 fecal samples. Antibodies against HEV were detected in 31 (36%) of 85 serum samples...
  66. Vollmer T, Diekmann J, Johne R, Eberhardt M, Knabbe C, Dreier J. Novel approach for detection of hepatitis E virus infection in German blood donors. J Clin Microbiol. 2012;50:2708-13 pubmed publisher
    The risk of transfusion-transmitted hepatitis E virus (HEV) infections by contaminated blood products remains unknown...
  67. El Sayed Zaki M, El Aal A, Badawy A, El Deeb D, El Kheir N. Clinicolaboratory study of mother-to-neonate transmission of hepatitis E virus in Egypt. Am J Clin Pathol. 2013;140:721-6 pubmed publisher
    ..To study the presence of hepatitis E viremia in neonates with congenital infections...
  68. Aggarwal R. Clinical presentation of hepatitis E. Virus Res. 2011;161:15-22 pubmed publisher
    Hepatitis E is a form of acute hepatitis, which is caused by infection with hepatitis E virus. The infection is transmitted primarily through fecal-oral route and the disease is highly endemic in several developing countries with ..
  69. Wenzel J, Preiss J, Schemmerer M, Huber B, Plentz A, Jilg W. Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates. J Clin Virol. 2011;52:50-4 pubmed publisher
    b>Hepatitis E virus (HEV) has been identified as an emerging cause of infectious hepatitis over the last years in developed countries...
  70. Fogeda M, Avellon A, Echevarria J. Prevalence of specific antibody to hepatitis E virus in the general population of the community of Madrid, Spain. J Med Virol. 2012;84:71-4 pubmed publisher
    b>Hepatitis E virus (HEV) is an infectious agent causing hepatitis among humans...
  71. Nidaira M, Takahashi K, Ogura G, Taira K, Okano S, Kudaka J, et al. Detection and phylogenetic analysis of hepatitis E viruses from mongooses in Okinawa, Japan. J Vet Med Sci. 2012;74:1665-8 pubmed
    b>Hepatitis E virus (HEV) infection has previously been reported in wild mongooses on Okinawa Island; to date however, only one HEV RNA sequence has been identified in a mongoose...
  72. C rdoba L, Huang Y, Opriessnig T, Harral K, Beach N, Finkielstein C, et al. Three amino acid mutations (F51L, T59A, and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation. J Virol. 2011;85:5338-49 pubmed publisher
    b>Hepatitis E virus (HEV) is an important but extremely understudied human pathogen, and the mechanisms of HEV replication and pathogenesis are largely unknown...
  73. Batts W, Yun S, Hedrick R, Winton J. A novel member of the family Hepeviridae from cutthroat trout (Oncorhynchus clarkii). Virus Res. 2011;158:116-23 pubmed publisher
    ..The genome of CTV was similar in size and organization to that of Hepatitis E virus (HEV) with which it shared the highest nucleotide and amino acid sequence identities...
  74. Nelson K, Kmush B, Labrique A. The epidemiology of hepatitis E virus infections in developed countries and among immunocompromised patients. Expert Rev Anti Infect Ther. 2011;9:1133-48 pubmed publisher
    b>Hepatitis E virus (HEV) is an important cause of acute hepatitis in humans worldwide, both as epidemic and sporadic disease...
  75. Dong C, Zafrullah M, Mixson Hayden T, Dai X, Liang J, Meng J, et al. Suppression of interferon-? signaling by hepatitis E virus. Hepatology. 2012;55:1324-32 pubmed publisher
    ..The effects of hepatitis E virus (HEV), the causative agent of hepatitis E, on IFN signaling have not been investigated primarily because of ..
  76. Xiao P, Li R, She R, Yin J, Li W, Mao J, et al. Prevalence of hepatitis e virus in swine fed on kitchen residue. PLoS ONE. 2012;7:e33480 pubmed publisher
    The aim of this study was to investigate the prevalence of swine hepatitis E virus (HEV) in pigs fed different feedstuffs (kitchen residue or mixed feeds) and genetic identification of HEV isolated in Hebei province, China...
  77. Backer J, Berto A, McCreary C, Martelli F, van der Poel W. Transmission dynamics of hepatitis E virus in pigs: estimation from field data and effect of vaccination. Epidemics. 2012;4:86-92 pubmed publisher
    Hepatitis E is a viral disease that causes serious concerns for public health. Hepatitis E virus (HEV) genotype 3 is endemic in commercial pig farms worldwide that act as a reservoir...
  78. Mulyanto -, Depamede S, Sriasih M, Takahashi M, Nagashima S, Jirintai S, et al. Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia. Arch Virol. 2013;158:87-96 pubmed publisher
    ..sixteen rats (Rattus rattus) captured in Indonesia from 2011 to 2012 were investigated for the prevalence of hepatitis E virus (HEV)-specific antibodies and HEV RNA...
  79. Jirintai S, Jinshan -, Tanggis -, Manglai D, Mulyanto -, Takahashi M, et al. Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells. Virus Res. 2012;170:126-37 pubmed publisher
    Rabbit hepatitis E virus (HEV) strains have recently been isolated in several areas of China and in the US and France...
  80. Li T, Ami Y, Suzaki Y, Yasuda S, Yoshimatsu K, Arikawa J, et al. Characterization of full genome of rat hepatitis E virus strain from Vietnam. Emerg Infect Dis. 2013;19:115-8 pubmed publisher
    We amplified the complete genome of the rat hepatitis E virus (HEV) Vietnam strain (V-105) and analyzed the nucleotide and amino acid sequences. The entire genome of V-105 shared only 76.8%-76...
  81. Feldt T, Sarfo F, Zoufaly A, Phillips R, Burchard G, van Lunzen J, et al. Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon. J Clin Virol. 2013;58:18-23 pubmed publisher
    Chronic hepatitis E virus (HEV) infections have recently been described in HIV-infected patients...
  82. Vasickova P, Slany M, Chalupa P, Holub M, Svoboda R, Pavlik I. Detection and phylogenetic characterization of human hepatitis E virus strains, Czech Republic. Emerg Infect Dis. 2011;17:917-9 pubmed publisher
    To determine the origin of hepatitis E virus in the Czech Republic, we analyzed patient clinical samples. Five isolates of genotypes 3e, 3f, and 3g were obtained...
  83. Suneetha P, Pischke S, Schlaphoff V, Grabowski J, Fytili P, Gronert A, et al. Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection. Hepatology. 2012;55:695-708 pubmed publisher
    b>Hepatitis E virus (HEV) infection is usually self-limited but may lead to acute hepatitis and rarely to fulminant hepatic failure...
  84. Nguyen H, Torian U, Faulk K, Mather K, Engle R, Thompson E, et al. A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. J Gen Virol. 2012;93:526-30 pubmed publisher
    b>Hepatitis E virus is the aetiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries...
  85. Kamar N, Bendall R, Legrand Abravanel F, Xia N, Ijaz S, Izopet J, et al. Hepatitis E. Lancet. 2012;379:2477-2488 pubmed publisher
    b>Hepatitis E virus (HEV) was discovered during the Soviet occupation of Afghanistan in the 1980s, after an outbreak of unexplained hepatitis at a military camp...
  86. Surjit M, Varshney B, Lal S. The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-?B activity by blocking ubiquitination mediated proteasomal degradation of I?B? in human hepatoma cells. BMC Biochem. 2012;13:7 pubmed publisher
    ..In this report we suggest a mechanism by which ORF2 protein of HEV may inhibit host cell NF-?B activity during the course of a viral infection...
  87. Colson P, Romanet P, Moal V, Borentain P, Purgus R, Benezech A, et al. Autochthonous infections with hepatitis E virus genotype 4, France. Emerg Infect Dis. 2012;18:1361-4 pubmed publisher
    During January-March 2011, diagnoses of hepatitis E virus (HEV) infection increased in Marseille University hospitals in southeastern France...
  88. Meldal B, Sarkodie F, Owusu Ofori S, Allain J. Hepatitis E virus infection in Ghanaian blood donors - the importance of immunoassay selection and confirmation. Vox Sang. 2013;104:30-6 pubmed publisher
    b>Hepatitis E virus (HEV) infection is emerging as a potential new threat to blood safety after several cases of transfusion-transmission were reported from non-epidemic countries...
  89. Rogée S, Talbot N, Caperna T, Bouquet J, Barnaud E, Pavio N. New models of hepatitis E virus replication in human and porcine hepatocyte cell lines. J Gen Virol. 2013;94:549-58 pubmed publisher
    b>Hepatitis E virus (HEV) causes acute, enterically transmitted hepatitis in human. It is associated with large epidemics in tropical and subtropical regions where it is endemic or with sporadic cases in non-endemic regions...
  90. Echevarria J, Gonzalez J, Lewis Ximenez L, Dos Santos D, Munne M, Pinto M, et al. Hepatitis E virus infection in Latin America: a review. J Med Virol. 2013;85:1037-45 pubmed publisher
    Data reported during recent years reveal the complex picture of the epidemiology of hepatitis E virus (HEV) infection in Latin America...
  91. Miyamura T. Hepatitis E virus infection in developed countries. Virus Res. 2011;161:40-6 pubmed publisher
    ..Recent developments of gene-based diagnostic assays and molecular epidemiology have disclosed the significance of hepatitis E virus infection in developed countries.
  92. La Rosa G, Muscillo M, Vennarucci V, Garbuglia A, La Scala P, Capobianchi M. Hepatitis E virus in Italy: molecular analysis of travel-related and autochthonous cases. J Gen Virol. 2011;92:1617-26 pubmed publisher
    Human hepatitis E virus (HEV) is considered an emerging pathogen in industrialized countries. The aim of the present study was to contribute to the body of knowledge available on the molecular epidemiology of acute hepatitis E in Italy...