gb virus b

Summary

Summary: A species of virus (tentatively placed in the genus HEPACIVIRUS) in the family FLAVIVIRIDAE, that was recovered from a tamarin monkey, but may have been of human origin. It causes HEPATITIS in several species of New World monkeys.

Top Publications

  1. Kyuregyan K, Poleschuk V, Zamyatina N, Isaeva O, Michailov M, Ross S, et al. Acute GB virus B infection of marmosets is accompanied by mutations in the NS5A protein. Virus Res. 2005;114:154-7 pubmed
    ..Appearance of these mutations presumably reflects a mechanism of immune escape rather than adaptation of the virus to a new host...
  2. Takikawa S, Engle R, Faulk K, Emerson S, Purcell R, Bukh J. Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins. J Gen Virol. 2010;91:727-33 pubmed publisher
    b>GB virus B (GBV-B) causes acute hepatitis in experimentally infected tamarins. We compared evolutionary features in acute resolving and persistent GBV-B infection...
  3. Weatherford T, Chavez D, Brasky K, Lemon S, Martin A, Lanford R. Lack of adaptation of chimeric GB virus B/hepatitis C virus in the marmoset model: possible effects of bottleneck. J Virol. 2009;83:8062-75 pubmed publisher
    Approximately 3% of the world population is chronically infected with hepatitis C virus (HCV). GB virus B (GBV-B), a surrogate model for HCV, causes hepatitis in tamarins and is the virus phylogenetically most closely related to HCV...
  4. Weatherford T, Chavez D, Brasky K, Lanford R. The marmoset model of GB virus B infections: adaptation to host phenotypic variation. J Virol. 2009;83:5806-14 pubmed publisher
    ..b>GB virus B (GBV-B), the virus phylogenetically most closely related to HCV, causes hepatitis in tamarins...
  5. Mankouri J, Milward A, Pryde K, Warter L, Martin A, Harris M. A comparative cell biological analysis reveals only limited functional homology between the NS5A proteins of hepatitis C virus and GB virus B. J Gen Virol. 2008;89:1911-20 pubmed publisher
    b>GB virus B (GBV-B) is the closest relative to hepatitis C virus (HCV) with which it shares a common genome organization, however, unlike HCV in humans, it generally causes an acute resolving hepatitis in New World monkeys...
  6. Ghibaudo D, Cohen L, Penin F, Martin A. Characterization of GB virus B polyprotein processing reveals the existence of a novel 13-kDa protein with partial homology to hepatitis C virus p7 protein. J Biol Chem. 2004;279:24965-75 pubmed
    ..b>GB virus B (GBV-B), a closely related hepatotropic virus that infects small New World primates and replicates efficiently ..
  7. Woollard D, Haqshenas G, Dong X, Pratt B, Kent S, Gowans E. Virus-specific T-cell immunity correlates with control of GB virus B infection in marmosets. J Virol. 2008;82:3054-60 pubmed
    b>GB virus B (GBV-B) is a hepatotropic virus that is closely related to hepatitis C virus (HCV). GBV-B causes acute hepatitis in infected marmosets and tamarins and is therefore a useful small-animal model for the study of HCV...
  8. Takikawa S, Engle R, Emerson S, Purcell R, St Claire M, Bukh J. Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein. Proc Natl Acad Sci U S A. 2006;103:3345-50 pubmed
    b>GB virus B (GBV-B), which infects tamarins, is the virus most closely related to hepatitis C virus (HCV). HCV has a protein (p7) that is believed to form an ion channel. It is critical for viability...
  9. Pizzuti M, De Tomassi A, Traboni C. Replication and IRES-dependent translation are both affected by core coding sequences in subgenomic GB virus B replicons. J Virol. 2003;77:7502-9 pubmed
    The yield of G418-resistant Huh7 cell clones bearing subgenomic dicistronic GB virus B (GBV-B) is significantly affected by the insertion of a portion of the viral core gene between the GBV-B 5' untranslated region and the exogenous ..

More Information

Publications45

  1. Warter L, Cohen L, Benureau Y, Chavez D, Yang Y, Bodola F, et al. A cooperative interaction between nontranslated RNA sequences and NS5A protein promotes in vivo fitness of a chimeric hepatitis C/GB virus B. PLoS ONE. 2009;4:e4419 pubmed publisher
    b>GB virus B (GBV-B) is closely related to hepatitis C virus (HCV), infects small non-human primates, and is thus a valuable surrogate for studying HCV...
  2. Griffin S, Trowbridge R, Thommes P, Parry N, Rowlands D, Harris M, et al. Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo. J Hepatol. 2008;49:908-15 pubmed publisher
    ..b>GB virus B (GBV-B), which infects new world monkeys, has been proposed as a surrogate system for HCV replication...
  3. Haqshenas G, Dong X, Netter H, Torresi J, Gowans E. A chimeric GB virus B encoding the hepatitis C virus hypervariable region 1 is infectious in vivo. J Gen Virol. 2007;88:895-902 pubmed
    Two GB virus B (GBV-B) chimeric genomes, GBV-HVR and GBV-HVRh (with a hinge), containing the coding region of the immunodominant hypervariable region 1 (HVR1) of the E2 envelope protein of Hepatitis C virus (HCV) were constructed...
  4. Chen Z, Benureau Y, Rijnbrand R, Yi J, Wang T, Warter L, et al. GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. J Virol. 2007;81:964-76 pubmed publisher
    ..b>GB virus B (GBV-B) is phylogenetically the closest related virus to HCV...
  5. Targett Adams P, Schaller T, Hope G, Lanford R, Lemon S, Martin A, et al. Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo. J Biol Chem. 2006;281:29221-7 pubmed publisher
    ..To answer these questions, we studied SPP processing in GB virus B (GBV-B) infection...
  6. Martin A, Bodola F, Sangar D, Goettge K, Popov V, Rijnbrand R, et al. Chronic hepatitis associated with GB virus B persistence in a tamarin after intrahepatic inoculation of synthetic viral RNA. Proc Natl Acad Sci U S A. 2003;100:9962-7 pubmed
    ..Whereas GB virus B (GBV-B, an unclassified flavivirus) shares a phylogenetic relationship and several biologic attributes with HCV, ..
  7. Bright H, Carroll A, Watts P, Fenton R. Development of a GB virus B marmoset model and its validation with a novel series of hepatitis C virus NS3 protease inhibitors. J Virol. 2004;78:2062-71 pubmed
    b>GB virus B (GBV-B), a flavivirus closely related to HCV, has previously been shown to infect and replicate to high titers in tamarins (Saguinus sp.)...
  8. Rijnbrand R, Thiviyanathan V, Kaluarachchi K, Lemon S, Gorenstein D. Mutational and structural analysis of stem-loop IIIC of the hepatitis C virus and GB virus B internal ribosome entry sites. J Mol Biol. 2004;343:805-17 pubmed
    Translation of the open reading frames (ORF) of the hepatitis C virus (HCV) and closely related GB virus B (GBV-B) genomes is driven by internal ribosome entry site (IRES) elements located within the 5' non-translated RNA...
  9. Nam J, Faulk K, Engle R, Govindarajan S, St Claire M, Bukh J. In vivo analysis of the 3' untranslated region of GB virus B after in vitro mutagenesis of an infectious cDNA clone: persistent infection in a transfected tamarin. J Virol. 2004;78:9389-99 pubmed
    b>GB virus B (GBV-B), the virus most closely related to hepatitis C virus (HCV), infects tamarins and causes acute hepatitis...
  10. Lanford R, Chavez D, Notvall L, Brasky K. Comparison of tamarins and marmosets as hosts for GBV-B infections and the effect of immunosuppression on duration of viremia. Virology. 2003;311:72-80 pubmed
    ..The greater availability of marmosets in comparison to tamarins will greatly facilitate future research efforts with this model...
  11. Jacob J, Lin K, Tennant B, Mansfield K. GB virus B infection of the common marmoset (Callithrix jacchus) and associated liver pathology. J Gen Virol. 2004;85:2525-33 pubmed
    b>GB virus B (GBV-B) is a flavivirus that is related closely to hepatitis C virus (HCV) and induces an acute hepatitis when inoculated into several species of New World primates...
  12. Hourioux C, Ait Goughoulte M, Patient R, Fouquenet D, Arcanger Doudet F, Brand D, et al. Core protein domains involved in hepatitis C virus-like particle assembly and budding at the endoplasmic reticulum membrane. Cell Microbiol. 2007;9:1014-27 pubmed
    ..The HCV core protein sequence was compared with its counterpart in GB virus B (GBV-B), the virus most closely related to HCV, to identify conserved domains...
  13. Rijnbrand R, Yang Y, Beales L, Bodola F, Goettge K, Cohen L, et al. A chimeric GB virus B with 5' nontranslated RNA sequence from hepatitis C virus causes hepatitis in tamarins. Hepatology. 2005;41:986-94 pubmed
    ..Here, we describe a chimeric virus derived from GB virus B (GBV-B), an unclassified hepatotropic member of the family Flaviviridae that is closely related to HCV and ..
  14. Manickam C, Rajakumar P, Wachtman L, Kramer J, Martinot A, Varner V, et al. Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection. J Virol. 2016;90:9153-62 pubmed publisher
    ..control of virus replication and virus-induced pathology caused by another, more rapidly resolving hepacivirus, GB virus B (GBV-B), in infections of common marmosets...
  15. Zhu S, Li T, Liu B, Xu Y, Sun Y, Wang Y, et al. Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus. J Virol. 2016;90:8198-211 pubmed publisher
    ..In this study, HCV/GB virus B (GBV-B) chimeric virus carrying the major nonstructural proteins NS2 to NS4A (HCV NS2 to -4A chimera) was ..
  16. Aurisicchio L, De Tomassi A, La Monica N, Ciliberto G, Traboni C, Palombo F. Regulated and liver-specific tamarin alpha interferon gene delivery by a helper-dependent adenoviral vector. J Virol. 2005;79:6772-80 pubmed
    ..Tamarins (Saguinus species) infected by GB virus B (GBV-B) are considered a valid surrogate model for hepatitis C to study the biology of HCV infection and the ..
  17. Manickam C, Martinot A, Jones R, Varner V, Reeves R. Hepatic immunopathology during occult hepacivirus re-infection. Virology. 2017;512:48-55 pubmed publisher
    ..Our data indicate that occult hepacivirus re-infections occur and that new liver pathology is possible even in the presence of anti-hepacivirus T cells and in the absence of high viremia. ..
  18. Marnata C, Saulnier A, Mompelat D, Krey T, Cohen L, Boukadida C, et al. Determinants Involved in Hepatitis C Virus and GB Virus B Primate Host Restriction. J Virol. 2015;89:12131-44 pubmed publisher
    Hepatitis C virus (HCV) only infects humans and chimpanzees, while GB virus B (GBV-B), another hepatotropic hepacivirus, infects small New World primates (tamarins and marmosets)...
  19. De Tomassi A, Pizzuti M, Traboni C. Hep3B human hepatoma cells support replication of the wild-type and a 5'-end deletion mutant GB virus B replicon. J Virol. 2003;77:11875-81 pubmed
    Hepatitis C virus (HCV) and GB virus B (GBV-B) replicons have been reported to replicate only in Huh7 cells...
  20. Lauck M, Sibley S, Lara J, Purdy M, Khudyakov Y, Hyeroba D, et al. A novel hepacivirus with an unusually long and intrinsically disordered NS5A protein in a wild Old World primate. J Virol. 2013;87:8971-81 pubmed publisher
    b>GB virus B (GBV-B; family Flaviviridae, genus Hepacivirus) has been studied in New World primates as a model for human hepatitis C virus infection, but the distribution of GBV-B and its relatives in nature has remained obscure...
  21. Sagan S, Sarnow P, Wilson J. Modulation of GB virus B RNA abundance by microRNA-122: dependence on and escape from microRNA-122 restriction. J Virol. 2013;87:7338-47 pubmed publisher
    ..b>GB virus B (GBV-B) is a hepatotropic virus and close relative of HCV...
  22. Benureau Y, Warter L, Malcolm B, Martin A. A comparative analysis of the substrate permissiveness of HCV and GBV-B NS3/4A proteases reveals genetic evidence for an interaction with NS4B protein during genome replication. Virology. 2010;406:228-40 pubmed publisher
    ..We compared substrate specificities of the HCV protease with that of the GB virus B (GBV-B), a distantly related nonhuman primate hepacivirus, by exchanging amino acid sequences at the NS4B/5A and/..
  23. Ranjith Kumar C, Gutshall L, Kim M, Sarisky R, Kao C. Requirements for de novo initiation of RNA synthesis by recombinant flaviviral RNA-dependent RNA polymerases. J Virol. 2002;76:12526-36 pubmed
    ..These and other results indicate that although the three RdRps share a common mechanism of de novo initiation, each has distinct preferences...
  24. Yokota T, Iijima S, Kubodera T, Ishii K, Katakai Y, Ageyama N, et al. Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C. Biochem Biophys Res Commun. 2007;361:294-300 pubmed
    ..Administration into marmosets of cationic liposome-encapsulated siRNA (CL-siRNA) for GB virus B (GBV-B), which is most closely related to hepatitis C virus, repressed GBV-B replication in a dose-dependent ..
  25. Ishii K, Iijima S, Kimura N, Lee Y, Ageyama N, Yagi S, et al. GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo. Microbes Infect. 2007;9:515-21 pubmed
    b>GB virus B (GBV-B) infection of New World monkeys is considered to be a useful surrogate model for hepatitis C virus (HCV) infection...
  26. Brass V, Pal Z, Sapay N, Deleage G, Blum H, Penin F, et al. Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses. J Virol. 2007;81:2745-57 pubmed
    ..Confocal laser scanning microscopy, as well as membrane flotation analyses, demonstrated that NS5As from GB virus B (GBV-B), GBV-C, and bovine viral diarrhea virus, the prototype pestivirus, display membrane association ..
  27. Buckwold V, Collins B, Hogan P, Rippeon S, Wei J. Investigation into the ability of GB virus B to replicate in various immortalized cell lines. Antiviral Res. 2005;66:165-8 pubmed
    b>GB virus B (GBV-B) is the most closely related virus to the hepatitis C virus (HCV) and is an attractive surrogate model system for HCV drug development efforts...
  28. Ranjith Kumar C, Santos J, Gutshall L, Johnston V, Lin Goerke J, Kim M, et al. Enzymatic activities of the GB virus-B RNA-dependent RNA polymerase. Virology. 2003;312:270-80 pubmed
    ..A chain terminating nucleotide analog could prevent RNA synthesis, while a nonnucleoside HCV inhibitor was unable to affect RNA synthesis by the GBV RdRp...
  29. Akari H, Iwasaki Y, Yoshida T, Iijima S. Non-human primate surrogate model of hepatitis C virus infection. Microbiol Immunol. 2009;53:53-7 pubmed publisher
    ..This review describes the characteristic of GBV-B infection of New World monkeys, and discusses current issues concerning the GBV-B model and its future directions...
  30. Chavez D, Guerra B, Lanford R. Antiviral activity and host gene induction by tamarin and marmoset interferon-alpha and interferon-gamma in the GBV-B primary hepatocyte culture model. Virology. 2009;390:186-96 pubmed publisher
    ..Since the GBV-B hepatocyte culture model possesses a functional innate immune response, it will provide opportunities to explore the nature of the antiviral response to a virus closely related to HCV...
  31. McGarvey M, Iqbal M, Nastos T, Karayiannis P. Restricted quasispecies variation following infection with the GB virus B. Virus Res. 2008;135:181-6 pubmed publisher
    The extent of genetic variability following acute infection of tamarins with GB virus B (GBV-B) is not known...
  32. Bukh J, Engle R, Govindarajan S, Purcell R. Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived. J Med Virol. 2008;80:87-94 pubmed
    ..We also demonstrated that the immunity was long-lived: 1 year after the fourth challenge, the animal with sterilizing immunity had low titer viremia for only 1 week following an additional challenge...
  33. Mee E, Greenhow J, Rose N. Characterisation of Mhc class I and class II DRB polymorphism in red-bellied tamarins (Saguinus labiatus). Immunogenetics. 2011;63:619-26 pubmed publisher
    The infection of red-bellied tamarins (Saguinus labiatus) with GB virus B (GBV-B) is an important surrogate model of hepatitis C virus infection in man...
  34. Suzuki S, Mori K, Higashino A, Iwasaki Y, Yasutomi Y, Maki N, et al. Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey. Microbiol Immunol. 2016;60:26-34 pubmed publisher
    ..the narrow host range of HCV, an HCV genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B (GBV-B), which is closely related to HCV, was generated...
  35. Lackner T, Muller A, Pankraz A, Becher P, Thiel H, Gorbalenya A, et al. Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. J Virol. 2004;78:10765-75 pubmed
    ..The biotype-specific modulation of NS2-3 autoprocessing indicates a crucial role of the NS2 autoprotease in the pathogenicity of BVDV...
  36. Premkumar A, Dong X, Haqshenas G, Gage P, Gowans E. Amantadine inhibits the function of an ion channel encoded by GB virus B, but fails to inhibit virus replication. Antivir Ther. 2006;11:289-95 pubmed
    A chemically synthesized peptide representing the C-terminal subunit (p13-C) of the p13 protein of GB virus B (GBV-B), the most closely related virus to hepatitis C virus (HCV) showed ion channel activity in artificial lipid bilayers...