suipoxvirus

Summary

Summary: A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, containing one species, swinepox virus.

Top Publications

  1. Massung R, Jayarama V, Moyer R. DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue. Virology. 1993;197:511-28 pubmed
    ..The lack of these functional homologues could explain the characteristic attenuated phenotype and limited host range of SPV...
  2. van der Leek M, Feller J, Sorensen G, Isaacson W, Adams C, Borde D, et al. Evaluation of swinepox virus as a vaccine vector in pigs using an Aujeszky's disease (pseudorabies) virus gene insert coding for glycoproteins gp50 and gp63. Vet Rec. 1994;134:13-8 pubmed
  3. Tripathy D. Swinepox virus as a vaccine vector for swine pathogens. Adv Vet Med. 1999;41:463-80 pubmed
  4. Winslow B, Kalabat D, Brown S, Cochran M, Collisson E. Feline B7.1 and B7.2 proteins produced from swinepox virus vectors are natively processed and biologically active: potential for use as nonchemical adjuvants. Vet Microbiol. 2005;111:1-13 pubmed
    ..Results from these studies establish the use of SPV as a mammalian expression vector and suggest that full-length-vectored and purified soluble feline B7 ligands may be valuable, nonchemical immune-modulators...
  5. Lin H, Ma Z, Fan H, Lu C. Construction and immunogenicity of recombinant swinepox virus expressing capsid protein of PCV2. Vaccine. 2012;30:6307-13 pubmed publisher
  6. Meng X, Schoggins J, Rose L, Cao J, Ploss A, Rice C, et al. C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1. J Virol. 2012;86:4538-47 pubmed publisher
  7. Xu J, Yang D, Huang D, Xu J, Liu S, Lin H, et al. Protection of guinea pigs by vaccination with a recombinant swinepox virus co-expressing HA1 genes of swine H1N1 and H3N2 influenza viruses. Arch Virol. 2013;158:629-37 pubmed publisher
    ..Our data suggest that the recombinant swinepox virus encoding HA1 of SIV H1N1 and H3N2 might serve as a promising candidate vaccine for protection against SIV H1N1 and H3N2 infections...
  8. Xu J, Huang D, Liu S, Lin H, Zhu H, Liu B, et al. Immune responses and protection efficacy of a recombinant swinepox virus expressing HA1 against swine H3N2 influenza virus in mice and pigs. Virus Res. 2012;167:188-95 pubmed publisher
    ..The data suggest that the SPV-based recombinant vector expressing HA1 of H3N2 SIV might serve as a promising SIV vaccine for protection against SIV infection...
  9. Nicholas A. A poxvirus of primates. II. Immunology. J Natl Cancer Inst. 1970;45:907-14 pubmed
    ..In contrast, neutralizing antibody titers remained high for 3 years, and monkeys that were challenged with OrTeCa virus were reFractory to a second infection...

More Information

Publications25

  1. Barcena J, Lorenzo M, Sánchez Puig J, Blasco R. Sequence and analysis of a swinepox virus homologue of the vaccinia virus major envelope protein P37 (F13L). J Gen Virol. 2000;81:1073-85 pubmed
    ..The lack of function of SPV P42 in the VV genetic background suggests that specific interactions between SPV P42 or VV P37 and other viral proteins is required to drive the envelopment process...
  2. Kawagishi Kobayashi M, Cao C, Lu J, Ozato K, Dever T. Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product. Virology. 2000;276:424-34 pubmed
    ..Thus, despite significant sequence differences both the C8L and K3L proteins function as pseudosubstrate inhibitors of PKR...
  3. Riyesh T, Barua S, Kumar N, Jindal N, Bera B, Narang G, et al. Isolation and genetic characterization of swinepox virus from pigs in India. Comp Immunol Microbiol Infect Dis. 2016;46:60-5 pubmed publisher
    Swinepox virus (SWPV), a member of the genus Suipoxvirus causes generalized pock-like lesions on the body of domestic and wild pigs...
  4. Lin H, Ma Z, Yang X, Fan H, Lu C. A novel vaccine against Porcine circovirus type 2 (PCV2) and Streptococcus equi ssp. zooepidemicus (SEZ) co-infection. Vet Microbiol. 2014;171:198-205 pubmed publisher
  5. Xu J, Huang D, Xu J, Liu S, Lin H, Zhu H, et al. Immune responses and protective efficacy of a recombinant swinepox virus co-expressing HA1 genes of H3N2 and H1N1 swine influenza virus in mice and pigs. Vet Microbiol. 2013;162:259-64 pubmed publisher
    ..Complete protection against SIV H1N1 or H3N2 challenge in pigs was observed...
  6. Yuan X, Lin H, Li B, He K, Fan H. Efficacy and immunogenicity of recombinant swinepox virus expressing the truncated S protein of a novel isolate of porcine epidemic diarrhea virus. Arch Virol. 2017;162:3779-3789 pubmed publisher
    ..Our data suggest that rSPV-St is potentially an effective vaccine against infection with emerging PEDV strains. ..
  7. Huang D, Zhu H, Lin H, Xu J, Lu C. First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice. Berl Munch Tierarztl Wochenschr. 2012;125:144-52 pubmed
    ..These initial results demonstrated that the rSPV-MRP provided mice with protection from systemic SS2 infection. If SPV recombinants have the potential as S. suis vaccines for the use in pigs has to be evaluated in further studies...
  8. Xu J, Huang D, Liu S, Lin H, Zhu H, Liu B, et al. Immune responses and protective efficacy of a recombinant swinepox virus expressing HA1 against swine H1N1 influenza virus in mice and pigs. Vaccine. 2012;30:3119-25 pubmed publisher
    ..Our data demonstrated that the recombinant swinepox virus encoding HA1 of SIV H1N1 may serve as a promising SIV vaccine for protection against SIV infection...
  9. Moorkamp L, Beineke A, Kaim U, Diesterbeck U, Urstadt S, Czerny C, et al. [Swinepox--skin disease with sporadic occurrence]. Dtsch Tierarztl Wochenschr. 2008;115:162-6 pubmed
    ..present report describes the occurrence of epidermal efflorescences in two piglets after intrauterine natural suipoxvirus infection...
  10. Afonso C, Tulman E, Lu Z, Zsak L, Osorio F, Balinsky C, et al. The genome of swinepox virus. J Virol. 2002;76:783-90 pubmed
    Swinepox virus (SWPV), the sole member of the Suipoxvirus genus of the Poxviridae, is the etiologic agent of a worldwide disease specific for swine. Here we report the genomic sequence of SWPV...
  11. Barcena J, Blasco R. Recombinant swinepox virus expressing beta-galactosidase: investigation of viral host range and gene expression levels in cell culture. Virology. 1998;243:396-405 pubmed
    ..The data presented suggest that despite the strict host tropism of SPV, the virus exhibits a relatively broad host range in cell culture...
  12. Lin H, Huang D, Wang Y, Lu C, Fan H. A novel vaccine against Streptococcus equi ssp. zooepidemicus infections: the recombinant swinepox virus expressing M-like protein. Vaccine. 2011;29:7027-34 pubmed publisher
    ..The results suggested that the recombinant rSPV-szp provided mice with significant protection from the SEZ infections. It is a promising candidate for the vaccine development against SEZ infections...
  13. Nicholas A. A poxvirus of primates. I. Growth of the virus in vitro and comparison with other poxviruses. J Natl Cancer Inst. 1970;45:897-905 pubmed
    ..The thermal stability of OrTeCa is about the same as that of vaccinia and monkeypox but greater than that of Yaba virus...
  14. Winslow B, Cochran M, Holzenburg A, Sun J, Junker D, Collisson E. Replication and expression of a swinepox virus vector delivering feline leukemia virus Gag and Env to cell lines of swine and feline origin. Virus Res. 2003;98:1-15 pubmed
    ..These results suggest that SPV may have potential as a safe vaccine delivery vector for cats...
  15. Solano Aguilar G, Zarlenga D, Beshah E, Vengroski K, Gasbarre L, Junker D, et al. Limited effect of recombinant porcine interleukin-12 on porcine lymphocytes due to a low level of IL-12 beta2 receptor. Vet Immunol Immunopathol. 2002;89:133-48 pubmed
    ..These data support a mechanism for IL-12 stimulation in swine inconsistent with that observed in conventional models...
  16. Hahn J, Park S, Song J, An S, Ahn B. Construction of recombinant swinepox viruses and expression of the classical swine fever virus E2 protein. J Virol Methods. 2001;93:49-56 pubmed
    ..Engineered with the gX signal sequence of the pseudorabies virus, and transmembrane domain of E2, the E2 protein was expressed as a dimeric form in the cytoplasm of the infected cells...