molluscum contagiosum virus

Summary

Summary: A species of MOLLUSCIPOXVIRUS causing skin lesions in humans. It is transmitted by direct contact or from non-living reservoirs (fomites), such as books or clothing.

Top Publications

  1. Garvey T, Bertin J, Siegel R, Lenardo M, Cohen J. The death effector domains (DEDs) of the molluscum contagiosum virus MC159 v-FLIP protein are not functionally interchangeable with each other or with the DEDs of caspase-8. Virology. 2002;300:217-25 pubmed
    The molluscum contagiosum virus (MCV) MC159 protein contains two death effector domains (DEDs) that bind to the DEDs of caspase-8 and FADD and inhibit apoptosis...
  2. Hahm G, McMahon J, Nuovo G, Pellegrini A, Vadmal M. Eosinophilic intranuclear inclusion bodies in a melanocytic nevus. Cutis. 2002;69:223-6 pubmed
    ..This result suggests that such inclusions may be related to molluscum viral infection of melanocytes. ..
  3. Trama J, Adelson M, Mordechai E. Identification and genotyping of molluscum contagiosum virus from genital swab samples by real-time PCR and Pyrosequencing. J Clin Virol. 2007;40:325-9 pubmed
    Laboratory diagnosis of molluscum contagiosum virus (MCV) is important as lesions can be confused with those caused by Cryptococcus neoformans, herpes simplex virus, human papillomavirus, and varicella-zoster virus...
  4. Senkevich T, Bugert J, Sisler J, Koonin E, Darai G, Moss B. Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes. Science. 1996;273:813-6 pubmed
    b>Molluscum contagiosum virus (MCV) commonly causes asymptomatic cutaneous neoplasms in children and sexually active adults as well as persistent opportunistic acquired immunodeficiency syndrome (AIDS)-associated disease...
  5. Watanabe T, Nakamura K, Wakugawa M, Kato A, Nagai Y, Shioda T, et al. Antibodies to molluscum contagiosum virus in the general population and susceptible patients. Arch Dermatol. 2000;136:1518-22 pubmed
    Since many attempts to cultivate molluscum contagiosum virus (MCV) in vitro have been unsuccessful, it is difficult to prepare a large quantity of antigens...
  6. Shisler J, Moss B. Molluscum contagiosum virus inhibitors of apoptosis: The MC159 v-FLIP protein blocks Fas-induced activation of procaspases and degradation of the related MC160 protein. Virology. 2001;282:14-25 pubmed
    b>Molluscum contagiosum virus contains two open reading frames, MC159 and MC160, that encode proteins with death effector domains resembling those of cellular regulators of apoptosis...
  7. Senkevich T, Koonin E, Bugert J, Darai G, Moss B. The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses. Virology. 1997;233:19-42 pubmed
    Analysis of the molluscum contagiosum virus (MCV) genome revealed that it encodes approximately 182 proteins, 105 of which have direct counterparts in orthopoxviruses (OPV)...
  8. Krathwohl M, Hromas R, Brown D, Broxmeyer H, Fife K. Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2. Proc Natl Acad Sci U S A. 1997;94:9875-80 pubmed
    ..The nucleotide sequence of the genome of the human cutaneous poxvirus, molluscum contagiosum virus (MCV) type 1, was recently reported to contain a region that resembles a human chemokine...
  9. Damon I, Murphy P, Moss B. Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog. Proc Natl Acad Sci U S A. 1998;95:6403-7 pubmed
    A secreted CC chemokine homolog, encoded by the MC148 gene of molluscum contagiosum virus, potently interfered with the chemotaxis of human monocytes, lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines ..

More Information

Publications105 found, 100 shown here

  1. Thompson C, Yager J, van Rensburg I. Close relationship between equine and human molluscum contagiosum virus demonstrated by in situ hybridisation. Res Vet Sci. 1998;64:157-61 pubmed
    ..These results indicate that on the basis of very close homology of their viral DNA sequences, the causative virus of equine molluscum contagiosum is either identical with, or very closely related to, its human equivalent...
  2. Senkevich T, Moss B. Domain structure, intracellular trafficking, and beta2-microglobulin binding of a major histocompatibility complex class I homolog encoded by molluscum contagiosum virus. Virology. 1998;250:397-407 pubmed
    The MC80R gene of molluscum contagiosum virus (MCV) type 1 encodes a major histocompatibility complex (MHC) class I homolog that lacks several amino-acid residues critical for peptide binding by MHC molecules, contains an unusually long ..
  3. Cohen J, Davila W, Ali M, Turk S, Cowen E, Freeman A, et al. Detection of molluscum contagiosum virus (MCV) DNA in the plasma of an immunocompromised patient and possible reduction of MCV DNA with CMX-001. J Infect Dis. 2012;205:794-7 pubmed publisher
    b>Molluscum contagiosum virus (MCV) is a poxvirus that causes localized papules in healthy persons. We evaluated a woman with severe immunodeficiency and disseminated MCV...
  4. Fife K, Whitfeld M, Faust H, Goheen M, Bryan J, Brown D. Growth of molluscum contagiosum virus in a human foreskin xenograft model. Virology. 1996;226:95-101 pubmed
    b>Molluscum contagiosum virus (MCV) is a common pathogen causing a troublesome skin condition in many immunocompetent individuals and a widespread, disfiguring affliction in many patients with AIDS...
  5. Xiang Y, Moss B. Molluscum contagiosum virus interleukin-18 (IL-18) binding protein is secreted as a full-length form that binds cell surface glycosaminoglycans through the C-terminal tail and a furin-cleaved form with only the IL-18 binding domain. J Virol. 2003;77:2623-30 pubmed
    ..Their different glycosaminoglycan and cell binding properties may allow the long and short forms of MC54L to inactivate IL-18 near the site of infection and at more distal locations, respectively...
  6. Vermi W, Fisogni S, Salogni L, Schärer L, Kutzner H, Sozzani S, et al. Spontaneous regression of highly immunogenic Molluscum contagiosum virus (MCV)-induced skin lesions is associated with plasmacytoid dendritic cells and IFN-DC infiltration. J Invest Dermatol. 2011;131:426-34 pubmed publisher
    b>Molluscum contagiosum virus (MCV) infection induces self-limiting cutaneous lesions in an immunocompetent host that can undergo spontaneous regression preceded by local inflammation...
  7. Netchiporouk E, Cohen B. Recognizing and managing eczematous id reactions to molluscum contagiosum virus in children. Pediatrics. 2012;129:e1072-5 pubmed publisher
    ..We hope that our report will make clinicians more aware of this common eczematous response to MC and will improve the management and counseling of these patients and their parents...
  8. Watanabe T, Morikawa S, Suzuki K, Miyamura T, Tamaki K, Ueda Y. Two major antigenic polypeptides of molluscum contagiosum virus. J Infect Dis. 1998;177:284-92 pubmed
    A library of molluscum contagiosum virus (MCV) transferred into the cowpox vector expression system was screened with 12 sera from molluscum patients...
  9. Hwang Y, Wang B, Bushman F. Molluscum contagiosum virus topoisomerase: purification, activities, and response to inhibitors. J Virol. 1998;72:3401-6 pubmed
    b>Molluscum contagiosum virus (MCV), the only member of the Molluscipoxvirus genus, causes benign papules in healthy people but disfiguring lesions in immunocompromised patients...
  10. Konya J, Thompson C. Molluscum contagiosum virus: antibody responses in persons with clinical lesions and seroepidemiology in a representative Australian population. J Infect Dis. 1999;179:701-4 pubmed
    An ELISA for molluscum contagiosum virus (MCV) was used to determine the antibody status of 35 adults with clinical infections and known human immunodeficiency virus (HIV) serology and of 357 persons (ages, 1 week-69 years) considered ..
  11. Chen X, Anstey A, Bugert J. Molluscum contagiosum virus infection. Lancet Infect Dis. 2013;13:877-88 pubmed publisher
    b>Molluscum contagiosum virus is an important human skin pathogen: it can cause disfigurement and suffering in children, in adults it is less common and often sexually transmitted...
  12. Konya J, Thompson C, De Zwart Steffe R. Enzyme-linked immunosorbent assay for measurement of IgG antibody to Molluscum contagiosum virus and investigation of the serological relationship of the molecular types. J Virol Methods. 1992;40:183-94 pubmed
    An ELISA was developed for measuring levels of IgG antibodies to Molluscum contagiosum virus (MCV) using DNA typed purified virus as antigen...
  13. Gil J, Rullas J, Alcami J, Esteban M. MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-kappaB activation and apoptosis induced by PKR. J Gen Virol. 2001;82:3027-34 pubmed
    b>Molluscum contagiosum virus (MCV) is a human poxvirus that causes abnormal proliferation of epithelial cells...
  14. Watanabe T, Tamaki K. Cidofovir diphosphate inhibits molluscum contagiosum virus DNA polymerase activity. J Invest Dermatol. 2008;128:1327-9 pubmed
  15. Buller R, Burnett J, Chen W, Kreider J. Replication of molluscum contagiosum virus. Virology. 1995;213:655-9 pubmed
    b>Molluscum contagiosum virus (MCV) infects preadolescent children and sexually active adults, frequently causing a disfiguring cutaneous disease in immunosuppressed HIV-infected individuals...
  16. Moss B, Shisler J, Xiang Y, Senkevich T. Immune-defense molecules of molluscum contagiosum virus, a human poxvirus. Trends Microbiol. 2000;8:473-7 pubmed
    b>Molluscum contagiosum virus encodes more than 150 proteins including some involved in host interactions that might contribute to prolonged viral replication in the skin...
  17. Garvey T, Bertin J, Siegel R, Wang G, Lenardo M, Cohen J. Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. J Virol. 2002;76:697-706 pubmed
    b>Molluscum contagiosum virus (MCV), a member of the human poxvirus family, encodes the MC159 protein that inhibits Fas-, tumor necrosis factor (TNF)-, and TNF-related apoptosis-inducing ligant (TRAIL)-induced apoptosis...
  18. Nichols D, Shisler J. The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation. J Virol. 2006;80:578-86 pubmed
    ..To prevent the detrimental effects of TNF-alpha in keratinocytes infected with the molluscum contagiosum virus (MCV), this poxvirus is expected to produce proteins that block at least one step of the TNF-RI signal ..
  19. Bertin J, Armstrong R, Ottilie S, Martin D, Wang Y, Banks S, et al. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A. 1997;94:1172-6 pubmed
    ..We report here that equine herpesvirus type 2 E8 protein and molluscum contagiosum virus MC159 protein both show sequence similarity to the death effector domains (DEDs) of the Fas/TNFR1 ..
  20. Agromayor M, Ortiz P, Lopez Estebaranz J, Gonzalez Nicolas J, Esteban M, Martin Gallardo A. Molecular epidemiology of molluscum contagiosum virus and analysis of the host-serum antibody response in Spanish HIV-negative patients. J Med Virol. 2002;66:151-8 pubmed
    b>Molluscum contagiosum virus (MCV) lesions from Spanish human immunodeficiency virus (HIV)-negative patients were clinically examined and analyzed for virus detection and typing...
  21. Harrison M, Desaulniers M, Noyce R, Evans D. The acidic C-terminus of vaccinia virus I3 single-strand binding protein promotes proper assembly of DNA-protein complexes. Virology. 2016;489:212-22 pubmed publisher
    ..We cloned and purified variants of the I3 protein, along with a homolog from molluscum contagiosum virus, and tested how the acidic tail affected DNA-protein interactions...
  22. Uemura T. [Molecular epidemiological study of molluscum contagiosum]. Nihon Hifuka Gakkai Zasshi. 1991;101:689-95 pubmed
    The agarose gel electrophoretic analysis of molluscum contagiosum virus (MCV) DNA obtained from 92 Japanese patients revealed the presence of four different BamHI cleavage patterns of MCV DNAs, classified as MCV-1,2,3 and 4...
  23. Yamashita H, Uemura T, Kawashima M. Molecular epidemiologic analysis of Japanese patients with molluscum contagiosum. Int J Dermatol. 1996;35:99-105 pubmed
    b>Molluscum contagiosum virus (MCV) causes molluscum contagiosum (MC) in both children and adults...
  24. Murao L, Shisler J. The MCV MC159 protein inhibits late, but not early, events of TNF-?-induced NF-?B activation. Virology. 2005;340:255-64 pubmed
    ..presumably interfere with the fulfillment of this immunity-associated event in cells infected with the molluscum contagiosum virus (MCV), this pathogen produces the intracellular MC159 protein...
  25. Mohr S, Grandemange S, Massimi P, Darai G, Banks L, Martinou J, et al. Targeting the retinoblastoma protein by MC007L, gene product of the molluscum contagiosum virus: detection of a novel virus-cell interaction by a member of the poxviruses. J Virol. 2008;82:10625-33 pubmed publisher
    The human pathogenic poxvirus molluscum contagiosum virus (MCV) is the causative agent of benign neoplasm, with worldwide incidence, characterized by intraepidermal hyperplasia and hypertrophy of cells...
  26. Hüttmann J, Krause E, Schommartz T, Brune W. Functional Comparison of Molluscum Contagiosum Virus vFLIP MC159 with Murine Cytomegalovirus M36/vICA and M45/vIRA Proteins. J Virol. 2015;90:2895-905 pubmed publisher
    b>Molluscum contagiosum virus (MCV) gene MC159 encodes a viral FLICE inhibitory protein (vFLIP) that inhibits caspase-8-mediated apoptosis...
  27. Smith K, Skelton H, Yeager J, James W, Wagner K. Molluscum contagiosum. Ultrastructural evidence for its presence in skin adjacent to clinical lesions in patients infected with human immunodeficiency virus type 1. Military Medical Consortium for Applied Retroviral Research. Arch Dermatol. 1992;128:223-7 pubmed
    ..Both routine histopathologic examination and ultrastructural examination were performed in two patients infected with human immunodeficiency virus type 1 (HIV-1) and three non-HIV-1-infected patients...
  28. Li F, Jeffrey P, Yu J, Shi Y. Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling. J Biol Chem. 2006;281:2960-8 pubmed
    ..Here we report a high resolution crystal structure of MC159, a v-FLIP derived from the molluscum contagiosum virus, which is a member of the human poxvirus family...
  29. Biswas S, Shisler J. Molluscum Contagiosum Virus MC159 Abrogates cIAP1-NEMO Interactions and Inhibits NEMO Polyubiquitination. J Virol. 2017;91: pubmed publisher
    b>Molluscum contagiosum virus (MCV) is a dermatotropic poxvirus that causes benign skin lesions. MCV lesions persist because of virally encoded immune evasion molecules that inhibit antiviral responses...
  30. Ridley C, Reddy M, Rocha G, Bushman F, Faulkner D. Total synthesis and evaluation of lamellarin alpha 20-Sulfate analogues. Bioorg Med Chem. 2002;10:3285-90 pubmed
    ..Lamellarin alpha 13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. ..
  31. Gupta R, Naran S, Lallu S, Fauck R. Cytologic diagnosis of molluscum contagiosum in scrape samples from facial lesions. Diagn Cytopathol. 2003;29:84 pubmed
  32. Arroyo Mühr L, Bzhalava D, Lagheden C, Eklund C, Johansson H, Forslund O, et al. Does human papillomavirus-negative condylomata exist?. Virology. 2015;485:283-8 pubmed publisher
    ..Three types were cloned and established as HPV types 200, 201 and 202. Molluscum contagiosum virus was detected in 24 of the 40 samples...
  33. Bell C, Eberly A, Takata G, Combs R, Deweese N, Whelen A. Specimens from a vesicular lesion caused by molluscum contagiosum virus produced a cytopathic effect in cell culture that mimicked that produced by herpes simplex virus. J Clin Microbiol. 2006;44:283-6 pubmed
    Infection with molluscum contagiosum virus, a poxvirus, normally has a typical clinical presentation; therefore, laboratory confirmation is infrequently sought and the virus is rarely isolated in culture...
  34. Behle V, Wobser M, Goebeler M, Stoevesandt J. Extensive molluscum contagiosum virus infection in a young adult receiving fingolimod. Mult Scler. 2016;22:969-71 pubmed publisher
    ..Neurologists prescribing fingolimod ought to be aware of a possibly increased risk of MC, but also need to know about its relative benignity, lack of extra-cutaneous complications, and adequate treatment options. ..
  35. Mihara M. Three-dimensional ultrastructural study of molluscum contagiosum in the skin using scanning-electron microscopy. Br J Dermatol. 1991;125:557-60 pubmed
    The three-dimensional ultrastructure of molluscum contagiosum virus (MCV) in human skin was visualized using scanning-electron microscopy with the osmium-dimethyl sulphoxide-osmium method...
  36. Shisler J, Senkevich T, Berry M, Moss B. Ultraviolet-induced cell death blocked by a selenoprotein from a human dermatotropic poxvirus. Science. 1998;279:102-5 pubmed
    ..The selenoprotein protected human keratinocytes against cytotoxic effects of ultraviolet irradiation and hydrogen peroxide, providing a mechanism for a virus to defend itself against environmental stress. ..
  37. Bugert J, Lohmüller C, Damon I, Moss B, Darai G. Chemokine homolog of molluscum contagiosum virus: sequence conservation and expression. Virology. 1998;242:51-9 pubmed
    An analysis of the complete Molluscum contagiosum virus (MCV-1) genome sequence revealed a 104-amino-acid open reading frame (MC148R) that is structurally related to the beta (CC) family of chemokines...
  38. Bugert J, Melquiot N, Kehm R. Molluscum contagiosum virus expresses late genes in primary human fibroblasts but does not produce infectious progeny. Virus Genes. 2001;22:27-33 pubmed
    b>Molluscum contagiosum virus (MCV), a member of the family Poxviridae, can be isolated from skin-lesion material of patients with molluscum contagiosum infection...
  39. Porter C, Archard L. Characterisation by restriction mapping of three subtypes of molluscum contagiosum virus. J Med Virol. 1992;38:1-6 pubmed
    DNA from Molluscum contagiosum virus (MCV) isolates was analysed by restriction endonuclease digestion, identifying three virus subtypes. The structural features of MCV DNA are typical of poxviral DNA...
  40. Hadasch R, Bugert J, Janssen W, Darai G. Characterization of the genome of molluscum contagiosum virus type 1 between the genome coordinates 0.045 and 0.075 by DNA nucleotide sequence analysis of a 5.6-kb HindIII/MluI DNA fragment. Intervirology. 1993;36:32-43 pubmed
    ..045-0.075 viral map units) from molluscum contagiosum virus type 1 (MCV-1) was determined...
  41. Egawa K, Honda Y, Ono T. Multiple giant molluscum contagiosa with cyst formation. Am J Dermatopathol. 1995;17:414-6 pubmed
    ..In all five cysts examined, the presence of molluscum contagiosum virus (MCV) was demonstrated electron microscopically, and the typical histological features of MCV infection ..
  42. Sonntag K, Darai G. Strategy for identifying the gene encoding the DNA polymerase of molluscum contagiosum virus type 1. Virus Genes. 1996;13:31-44 pubmed
    b>Molluscum contagiosum virus (MCV) is a member of the family Poxviridae and pathogenic to humans. MCV causes benign epidermal tumors mainly in children and young adults and is a common pathogen in immunecompromised individuals...
  43. Hwang Y, Rowley D, Rhodes D, Gertsch J, Fenical W, Bushman F. Mechanism of inhibition of a poxvirus topoisomerase by the marine natural product sansalvamide A. Mol Pharmacol. 1999;55:1049-53 pubmed
    At present no antiviral agents are available for treatment of infection by the pathogenic poxvirus molluscum contagiosum virus (MCV)...
  44. Connell C, Oranje A, Van Gysel D, Silverberg N. Congenital molluscum contagiosum: report of four cases and review of the literature. Pediatr Dermatol. 2008;25:553-6 pubmed publisher
    ..contagiosum is a viral infection of the skin and mucous membranes that is caused by infection with the molluscum contagiosum virus. Molluscum contagiosum can be acquired from skin to skin contact which may be during play, in a ..
  45. Brady G, Haas D, Farrell P, Pichlmair A, Bowie A. Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation. J Virol. 2017;91: pubmed publisher
    b>Molluscum contagiosum virus (MCV), the only known extant human-adapted poxvirus, causes a long-duration infection characterized by skin lesions that typically display an absence of inflammation despite containing high titers of live ..
  46. López Bueno A, Parras Moltó M, López Barrantes O, Belda S, Alejo A. Recombination events and variability among full-length genomes of co-circulating molluscum contagiosum virus subtypes 1 and 2. J Gen Virol. 2017;98:1073-1079 pubmed publisher
    b>Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged ..
  47. Lange L, Marett S, Maree C, Gerdes T. Molluscum contagiosum in three horses. J S Afr Vet Assoc. 1991;62:68-71 pubmed
    ..Microscopically cytoplasmic inclusions containing many pox virions were found. Attempts at culturing the virus were unsuccessful. ..
  48. Porter C, Blake N, Archard L, Muhlemann M, Rosedale N, Cream J. Molluscum contagiosum virus types in genital and non-genital lesions. Br J Dermatol. 1989;120:37-41 pubmed
    The endonuclease digest patterns of viral DNA from 48 genital and 45 non-genital molluscum contagiosum virus (MCV) lesions were examined. The overall ratio of MCVI to MCVII was 3.23:1...
  49. Seitz B. [Chronic unilateral keratoconjunctivitis in molluscum contagiosum of the upper eyelid margin]. Klin Monbl Augenheilkd. 1994;204:142-3 pubmed
    ..In older patients a sebaceous gland carcinoma must be ruled out. Considering the patient's personal history a chlamydial infection should be kept in mind as a differential diagnosis. ..
  50. Chen N, Baudino T, MacDonald P, Green M, Kelley W, Burnett J, et al. Selective inhibition of nuclear steroid receptor function by a protein from a human tumorigenic poxvirus. Virology. 2000;274:17-25 pubmed
    ..MC013L may be the first member of a new class of poxvirus proteins that directly modulate nuclear receptor-mediated transcription. ..
  51. Brandrup F, Asschenfeldt P. Molluscum contagiosum-induced comedo and secondary abscess formation. Pediatr Dermatol. 1989;6:118-21 pubmed
  52. Simonart T, Noel J, Van Vooren J, Hermans P, Liesnard C, Fayt I, et al. PCR assay fails to detect molluscum contagiosum virus-related sequences in AIDS-related Kaposi's sarcoma. J Virol Methods. 1998;73:83-7 pubmed
    ..contagiosum occurrence was found and this study was conducted primarily to search for the presence of molluscum contagiosum virus DNA sequences in KS...
  53. Ishikawa Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. FEBS Lett. 1999;460:544-8 pubmed
    b>Molluscum contagiosum virus (MCV) encodes a CC chemokine MC148R which is likely to have been acquired from the host...
  54. Shalders K, Ilchyshyn A, Walzman M. Secondary anetoderma following molluscum contagiosum infection. Acta Derm Venereol. 2003;83:461-2 pubmed
  55. Challa S, Woelfel M, Guildford M, Moquin D, Chan F. Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection. J Virol. 2010;84:10467-76 pubmed publisher
    ..Surprisingly, transgenic expression of the viral FLIP MC159 from molluscum contagiosum virus (MCV) in mice enhanced rather than inhibited the innate immune control of vaccinia virus (VV) ..
  56. Lee R, Schwartz R. Pediatric molluscum contagiosum: reflections on the last challenging poxvirus infection, Part 1. Cutis. 2010;86:230-6 pubmed
    ..The 3 major therapeutic modalities employed are physical destruction, immunomodulation, and antiviral agents. Combinations of these therapies may be employed. Therapeutic modalities will be discussed in part 2...
  57. Nakamura J, Muraki Y, Yamada M, Hatano Y, Nii S. Analysis of molluscum contagiosum virus genomes isolated in Japan. J Med Virol. 1995;46:339-48 pubmed
    The genomes of 477 Japanese strains of molluscum contagiosum virus (MCV) were analyzed using an in-gel digestion method with the restriction enzyme BamHI, and classified into four types, including a newly detected type (MCV type 4)...
  58. Sonntag K, Clauer U, Bugert J, Schnitzler P, Darai G. Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus. Virology. 1995;210:471-8 pubmed
    The DNA-dependent RNA polymerase (DdRP) is an essential enzyme for transcription of molluscum contagiosum virus (MCV), a member of the family Poxviridae which replicates in the cytoplasm of the infected cell...
  59. Randall C, Biswas S, Selen C, Shisler J. Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus. Proc Natl Acad Sci U S A. 2014;111:E265-72 pubmed publisher
    ..Here we examine FLIPs (MC159 and MC160) encoded by the molluscum contagiosum virus, a dermatotropic poxvirus causing skin infections common in children and immunocompromised individuals, ..
  60. Thompson C, De Zwart Steffe R, Biggs I. Molecular epidemiology of Australian isolates of molluscum contagiosum. J Med Virol. 1990;32:1-9 pubmed
  61. Xiang Y, Moss B. Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus. Virology. 1999;257:297-302 pubmed
    b>Molluscum contagiosum virus (MCV) is a human poxvirus that produces small, benign skin tumors primarily in young children and encodes proteins that modulate the host immune response...
  62. Upton C. Screening predicted coding regions in poxvirus genomes. Virus Genes. 2000;20:159-64 pubmed
    ..Analysis of molluscum contagiosum virus ORFs by amino acid composition and pI identified a number of ORFs previously denoted as doubtful and ..
  63. Niimura M. [Molluscum contagiosum]. Nihon Rinsho. 2003;61 Suppl 2:205-8 pubmed
  64. Moser B. T-cell memory: the importance of chemokine-mediated cell attraction. Curr Biol. 2006;16:R504-7 pubmed
    ..A recent study demonstrates the involvement of certain chemokines in immune response initiation and CD8+ T-cell memory formation. These seminal findings broaden our understanding of the role of chemokines in adaptive immune processes...
  65. Grillo E, Urech M, Vano Galvan S, Jaen P. Lesions on tattooed skin--a case study. Aust Fam Physician. 2012;41:308-9 pubmed
    ..Tests for human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus and syphilis were negative and full blood examination was normal...
  66. Johansson H, Bzhalava D, Ekström J, Hultin E, Dillner J, Forslund O. Metagenomic sequencing of "HPV-negative" condylomas detects novel putative HPV types. Virology. 2013;440:1-7 pubmed publisher
    ..Complete genomes of Gammapillomavirus FA69 and SE87 were compiled. Metagenomic sequencing reveals that seemingly "HPV-negative" condylomas contain known and previously unknown HPV types...
  67. Hurst J, Forghani B, Chan C, Oshiro L, Darai G. Direct detection of molluscum contagiosum virus in clinical specimens by dot blot hybridization. J Clin Microbiol. 1991;29:1959-62 pubmed
    A dot blot hybridization protocol was developed for the direct detection of molluscum contagiosum virus (MCV) DNA in clinical specimens submitted for virus isolation...
  68. Sonntag K, Darai G. Evolution of viral DNA-dependent RNA polymerases. Virus Genes. 1995;11:271-84 pubmed
    ..subunit of DdRP of insect iridescent virus type 6 (IIV6), fish lymphocystis disease virus (LCDV), and molluscum contagiosum virus (MCV-1), all members of the group of cytoplasmic DNA viruses, were identified by PCR technology...
  69. Hwang Y, Park M, Fischer W, Burgin A, Bushman F. DNA contacts by protein domains of the molluscum contagiosum virus type-1B topoisomerase. Virology. 1999;262:479-91 pubmed
    ..These findings provide insight into the division of labor within the MCV-TOP enzyme...
  70. Willer D, McFadden G, Evans D. The complete genome sequence of shope (rabbit) fibroma virus. Virology. 1999;264:319-43 pubmed
    ..SFV also encodes a type II DNA photolyase (S127L). Melanoplus sanguinipes entomopoxvirus encodes a similar protein, but SFV is the first mammalian virus potentially capable of photoreactivating ultraviolet DNA damage...
  71. Kvell K, Nguyen T, Salmon P, Glauser F, Werner Favre C, Barnet M, et al. Transduction of CpG DNA-stimulated primary human B cells with bicistronic lentivectors. Mol Ther. 2005;12:892-9 pubmed
    ..This system should be useful for gene function research in primary B cells and development of gene therapies...
  72. Lee R, Schwartz R. Pediatric molluscum contagiosum: reflections on the last challenging poxvirus infection, Part 2. Cutis. 2010;86:287-92 pubmed
    ..Therapeutic modalities are subdivided into 3 types: destructive, immunomodulatory, and antiviral. We review the advantages and disadvantages of various agents and discuss combination therapy...
  73. Alam M, Shrirao N. Giant molluscum contagiosum presenting as lid neoplasm in an immunocompetent child. Dermatol Online J. 2016;22: pubmed
    ..It is rare for molluscum contagiosum to present as a solitary lid tumor. A brain like appearance of the excised mass can provide a clue towards the diagnosis. ..
  74. Scholz J, Rosen Wolff A, Bugert J, Reisner H, White M, Darai G, et al. Epidemiology of molluscum contagiosum using genetic analysis of the viral DNA. J Med Virol. 1989;27:87-90 pubmed
    The molecular epidemiology of molluscum contagiosum virus (MCV) infections was investigated by restriction endonuclease analysis of the genomes of 222 separate isolates collected from 147 patients living in Germany (33 patients), Hong ..
  75. Douglass N, Blake N, Cream J, Soteriou B, Zhang H, Theodoridou A, et al. Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid. J Gen Virol. 1996;77 ( Pt 12):3113-20 pubmed
    b>Molluscum contagiosum virus (MCV) and vaccinia virus (VV) are serologically unrelated poxviruses with a disparate genome composition (MCV, 66% G+C; VV, 33% G+C)...
  76. Moratilla M, Agromayor M, Nunez A, Funes J, Varas A, Lopez Estebaranz J, et al. A random DNA sequencing, computer-based approach for the generation of a gene map of molluscum contagiosum virus. Virus Genes. 1997;14:73-80 pubmed
    The genome of Molluscum contagiosum virus (MCV) has a high G + C content, which largely differs from those of vaccinia virus (VAC) and other characterized poxviruses...
  77. Jain S, Das D, Malhotra V, Tatke M, Kumar N. Molluscum contagiosum. A case report with fine needle aspiration cytologic diagnosis and ultrastructural features. Acta Cytol. 2000;44:63-6 pubmed
    ..Cytomorphologic and ultrastructural features of molluscum contagiosum, a rare skin lesion of viral etiology, are presented...
  78. Hwang Y, Rhodes D, Bushman F. Rapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolation. Nucleic Acids Res. 2000;28:4884-92 pubmed
    ..New integrase inhibitors were also identified. A similar strategy may be used to develop microtiter assays for many further DNA modifying enzymes...
  79. Xiang Y, Moss B. Correspondence of the functional epitopes of poxvirus and human interleukin-18-binding proteins. J Virol. 2001;75:9947-54 pubmed
    b>Molluscum contagiosum virus, a human poxvirus that causes persistent small benign skin tumors, encodes a variety of putative immune defense proteins...
  80. Wu Z, Roberts M, Porter M, Walker F, Wherry E, Kelly J, et al. Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J Immunol. 2004;172:6313-23 pubmed
    ..In this study, we show that T cell-specific transgenic expression of MC159-vFLIP from the human Molluscum contagiosum virus blocks CD95-induced apoptosis in thymocytes and peripheral T cells, but also impairs postactivation ..
  81. Turkoglu S, Cakmak O, Kaya S, Colak A, Demirhan B. Pathology quiz case 2: Molluscum contagiosum. Arch Otolaryngol Head Neck Surg. 2007;133:199, 201 pubmed
  82. Antoniou C, Kosmadaki M, Stratigos A, Katsambas A. Genital HPV lesions and molluscum contagiosum occurring in patients receiving anti-TNF-alpha therapy. Dermatology. 2008;216:364-5 pubmed publisher
  83. Butala N, Siegfried E, Weissler A. Molluscum BOTE sign: a predictor of imminent resolution. Pediatrics. 2013;131:e1650-3 pubmed publisher
    ..We propose the acronym "BOTE"* sign (for beginning of the end) to help underscore the significance of inflammation as an expected variant in the evolution of molluscum immunity...
  84. Thompson C, Biggs I, De Zwart Steffe R. Detection of molluscum contagiosum virus DNA by in situ hybridization. Pathology. 1990;22:181-6 pubmed
    ..modified and used to comparatively examine formalin-fixed, paraffin-embedded tissue for the presence of molluscum contagiosum virus (MCV) DNA...
  85. Martin Gallardo A, Moratilla M, Funes J, Agromayor M, Nunez A, Varas A, et al. Sequence analysis of a Molluscum contagiosum virus DNA region which includes the gene encoding protein kinase 2 and other genes with unique organization. Virus Genes. 1996;13:19-29 pubmed
    The nucleotide sequence of a near left-terminal region from the genome of Molluscum contagiosum virus subtype I (MCVI) was determined. This region was contained within three adjacent BamHI fragments, designated L (2...
  86. Hwang Y, Burgin A, Bushman F. DNA contacts stimulate catalysis by a poxvirus topoisomerase. J Biol Chem. 1999;274:9160-8 pubmed
    ..These data 1) indicate that previously unidentified DNA contacts can accelerate a step between initial binding and covalent complex formation and 2) help specify models for conformational changes promoting catalysis...
  87. Bugert J, Lohmüller C, Darai G. Characterization of early gene transcripts of molluscum contagiosum virus. Virology. 1999;257:119-29 pubmed
    b>Molluscum contagiosum virus (MCV), a member of the family Poxviridae, replicates well in vivo but cannot be propagated in cell culture. The coding capacity of the MCV genome was previously determined by DNA nucleotide sequence analysis...
  88. Reddy M, Rao M, Rhodes D, Hansen M, Rubins K, Bushman F, et al. Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture. J Med Chem. 1999;42:1901-7 pubmed
    ..In addition, these single round tests rule out action against viral assembly or budding. These findings provide a new class of compounds for potential development of clinically useful integrase inhibitors...
  89. Molteni V, Rhodes D, Rubins K, Hansen M, Bushman F, Siegel J. A new class of HIV-1 integrase inhibitors: the 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol family. J Med Chem. 2000;43:2031-9 pubmed
    ..Importantly, the efficiency is different when Mg(2+), the more likely in vivo cofactor, is used. These data emphasize the importance of assays with Mg(2+) and offer new catechol isosteres for use in integrase inhibitors...
  90. Berman B. Imiquimod: a new immune response modifier for the treatment of external genital warts and other diseases in dermatology. Int J Dermatol. 2002;41 Suppl 1:7-11 pubmed
  91. Hosnjak L, Kocjan B, Kušar B, Seme K, Poljak M. Rapid detection and typing of Molluscum contagiosum virus by FRET-based real-time PCR. J Virol Methods. 2013;187:431-4 pubmed publisher
    ..transfer (FRET)-based real-time PCR (RT-PCR) was developed for very sensitive and specific detection of Molluscum contagiosum virus (MCV), as well as reliable differentiation of the two MCV subtype genetic lineages, MCV1 and MCV2, in a ..
  92. Coutu J, Ryerson M, Bugert J, Brian Nichols D. The Molluscum Contagiosum Virus protein MC163 localizes to the mitochondria and dampens mitochondrial mediated apoptotic responses. Virology. 2017;505:91-101 pubmed publisher
    ..Poxviruses have evolved complex means to dampen cellular apoptotic responses. The poxvirus, Molluscum Contagiosum Virus (MCV), encodes numerous host interacting molecules predicted to antagonize immune responses...