polydnaviridae

Summary

Summary: A family of insect viruses isolated from endoparasitic hymenopteran insects belonging to the families Ichneumonidae and Braconidae. The two genera are Ichnovirus and Bracovirus.

Top Publications

  1. Turnbull M, Webb B. Perspectives on polydnavirus origins and evolution. Adv Virus Res. 2002;58:203-54 pubmed
  2. Amaya K, Asgari S, Jung R, Hongskula M, Beckage N. Parasitization of Manduca sexta larvae by the parasitoid wasp Cotesia congregata induces an impaired host immune response. J Insect Physiol. 2005;51:505-12 pubmed
    ..A CrV1-homolog gene product was localized in host hemocytes using polyclonal CrV1 antibodies, suggesting that CrV1-like gene products of C. congregata's bracovirus are responsible for the impaired immune response of the host. ..
  3. Asgari S, Schmidt O. A coiled-coil region of an insect immune suppressor protein is involved in binding and uptake by hemocytes. Insect Biochem Mol Biol. 2002;32:497-504 pubmed
    ..Here, we show that a coiled-coil domain containing a putative leucine zipper is required for CrV1 function, since removal of this domain abolishes binding and uptake of the CrV1 protein by hemocytes. ..
  4. Kroemer J, Webb B. Ikappabeta-related vankyrin genes in the Campoletis sonorensis ichnovirus: temporal and tissue-specific patterns of expression in parasitized Heliothis virescens lepidopteran hosts. J Virol. 2005;79:7617-28 pubmed
    ..We hypothesize that PDV vankyrin genes may suppress NF-kappabeta activity during immune responses and developmental cascades in parasitized lepidopteran hosts of C. sonorensis. ..
  5. Dupas S, Gitau C, Branca A, Le Ru B, Silvain J. Evolution of a polydnavirus gene in relation to parasitoid-host species immune resistance. J Hered. 2008;99:491-9 pubmed publisher
    ..We discuss the forces driving the evolution of CrV1 and its use as a marker to understand parasitoid adaptation to host resistance in biological control. ..
  6. Wyler T, Lanzrein B. Ovary development and polydnavirus morphogenesis in the parasitic wasp Chelonus inanitus. II. Ultrastructural analysis of calyx cell development, virion formation and release. J Gen Virol. 2003;84:1151-63 pubmed
    ..On the border of the oviduct lumen, cells of an epithelial layer become phagocytic and remove debris, leading to a calyx fluid that contains only densely packed virions. ..
  7. Friedman R, Hughes A. Pattern of gene duplication in the Cotesia congregata Bracovirus. Infect Genet Evol. 2006;6:315-22 pubmed
    ..Phylogenies provided no unequivocal evidence of horizontal gene transfer between the wasp host and the polydnavirus, but in some cases there were suggestions of such gene transfer. ..
  8. Ibrahim A, Choi J, Je Y, Kim Y. Protein tyrosine phosphatases encoded in Cotesia plutellae bracovirus: sequence analysis, expression profile, and a possible biological role in host immunosuppression. Dev Comp Immunol. 2007;31:978-90 pubmed
    ..xylostella. These results suggest that CpBV-PTPs are expressed in the parasitized P. xylostella and affect cellular PTP activity, which may be associated with host immunosuppression. ..
  9. Schafellner C, Marktl R, Schopf A. Inhibition of juvenile hormone esterase activity in Lymantria dispar (Lepidoptera, Lymantriidae) larvae parasitized by Glyptapanteles liparidis (Hymenoptera, Braconidae). J Insect Physiol. 2007;53:858-68 pubmed
    ..We compare the results with those reported earlier for L. dispar larvae parasitized by G. liparidis and discuss the possible role of JH alterations in host development disruption. ..

More Information

Publications89

  1. Weber B, Annaheim M, Lanzrein B. Transcriptional analysis of polydnaviral genes in the course of parasitization reveals segment-specific patterns. Arch Insect Biochem Physiol. 2007;66:9-22 pubmed
    ..This is the first observation of this type. It suggests that one function of the segmentation of the polydnavirus genome may be the grouping together of genes, which are regulated in a similar manner. ..
  2. Gundersen Rindal D, Pedroni M. Characterization and transcriptional analysis of protein tyrosine phosphatase genes and an ankyrin repeat gene of the parasitoid Glyptapanteles indiensis polydnavirus in the parasitized host. J Gen Virol. 2006;87:311-22 pubmed
    ..Tissue-specific patterns of PTP expression of GiBV segF genes were variable, suggesting differing roles in facilitating parasitism. ..
  3. Bézier A, Herbinière J, Lanzrein B, Drezen J. Polydnavirus hidden face: the genes producing virus particles of parasitic wasps. J Invertebr Pathol. 2009;101:194-203 pubmed publisher
    ..This highlights the fact that viruses should no longer be exclusively considered obligatory parasites, and that in certain cases they are obligatory symbionts...
  4. Pruijssers A, Falabella P, Eum J, Pennacchio F, Brown M, Strand M. Infection by a symbiotic polydnavirus induces wasting and inhibits metamorphosis of the moth Pseudoplusia includens. J Exp Biol. 2009;212:2998-3006 pubmed publisher
    ..Taken together, our results suggest MdBV causes alterations in metabolic physiology, which prevent the host from achieving critical weight. This in turn inhibits the endocrine events that normally trigger metamorphosis. ..
  5. Pasquier Barre F, Dupuy C, Huguet E, Monteiro F, Moreau A, Poirie M, et al. Polydnavirus replication: the EP1 segment of the parasitoid wasp Cotesia congregata is amplified within a larger precursor molecule. J Gen Virol. 2002;83:2035-45 pubmed
    ..These findings shed light on a new step towards EP1 circle production: the amplification of virus sequences preceding individual circle excision. ..
  6. Thoetkiattikul H, Beck M, Strand M. Inhibitor kappaB-like proteins from a polydnavirus inhibit NF-kappaB activation and suppress the insect immune response. Proc Natl Acad Sci U S A. 2005;102:11426-31 pubmed
    ..Collectively, these results indicate that H4 and N5 function as IkappaBs and, circumstantially, suggest that other IkappaB-like gene family members are involved in the suppression of the insect immune system. ..
  7. Kwon B, Song S, Choi J, Je Y, Kim Y. Transient expression of specific Cotesia plutellae bracoviral segments induces prolonged larval development of the diamondback moth, Plutella xylostella. J Insect Physiol. 2010;56:650-8 pubmed publisher
    ..xylostella. These results suggest that CpBV can induce prolonged larval development of P. xylostella, and that at least some CpBV-PTPs may contribute to the parasitic role probably by altering titers of developmental hormones. ..
  8. Branca A, Le Ru B, Vavre F, Silvain J, Dupas S. Intraspecific specialization of the generalist parasitoid Cotesia sesamiae revealed by polyDNAvirus polymorphism and associated with different Wolbachia infection. Mol Ecol. 2011;20:959-71 pubmed publisher
    ..sesamiae. This mechanism could be applicable to other insect models because of the high prevalence of Wolbachia in insects...
  9. Thézé J, Bézier A, Periquet G, Drezen J, Herniou E. Paleozoic origin of insect large dsDNA viruses. Proc Natl Acad Sci U S A. 2011;108:15931-5 pubmed publisher
    ..These results imply ancient coevolution by resource tracking between several insect dsDNA virus families and their hosts, dating back to 310 Mya...
  10. Fath Goodin A, Kroemer J, Webb B. The Campoletis sonorensis ichnovirus vankyrin protein P-vank-1 inhibits apoptosis in insect Sf9 cells. Insect Mol Biol. 2009;18:497-506 pubmed publisher
    ..This is the first report of a polydnavirus protein with anti-apoptotic function. ..
  11. Dupas S, Turnbull M, Webb B. Diversifying selection in a parasitoid's symbiotic virus among genes involved in inhibiting host immunity. Immunogenetics. 2003;55:351-61 pubmed
    ..The positive selection and duplication of both the gene family and the cys-motif implies either selection is driving the molecular radiation of immune suppressive genes toward novel hosts, or molecular coevolution with host targets. ..
  12. Desjardins C, Gundersen Rindal D, Hostetler J, Tallon L, Fadrosh D, Fuester R, et al. Comparative genomics of mutualistic viruses of Glyptapanteles parasitic wasps. Genome Biol. 2008;9:R183 pubmed publisher
    ..Here we characterize and compare the encapsidated viral genome sequences of bracoviruses in the family Polydnaviridae associated with Glyptapanteles gypsy moth parasitoids, along with near complete proviral sequences from which ..
  13. Galibert L, Devauchelle G, Cousserans F, Rocher J, Cerutti P, Barat Houari M, et al. Members of the Hyposoter didymator Ichnovirus repeat element gene family are differentially expressed in Spodoptera frugiperda. Virol J. 2006;3:48 pubmed
    ..In this work, we report a relative quantitative transcription study of these HdIV rep genes in several tissues of the lepidopteran host Spodoptera frugiperda as well as in the H. didymator wasps...
  14. Ibrahim A, Kim Y. Transient expression of protein tyrosine phosphatases encoded in Cotesia plutellae bracovirus inhibits insect cellular immune responses. Naturwissenschaften. 2008;95:25-32 pubmed
    ..This is the first report demonstrating that the polydnaviral PTPs can manipulate PTP activity of the hemocytes to interrupt cellular immune responses. ..
  15. Volkoff A, Cerutti P, Rocher J, Ohresser M, Devauchelle G, Duonor Cerutti M. Related RNAs in lepidopteran cells after in vitro infection with Hyposoter didymator virus define a new polydnavirus gene family. Virology. 1999;263:349-63 pubmed
    ..We propose that the three cloned genes belong to an HdV gene family specifically expressed in parasitized lepidopteran hosts. ..
  16. Volkoff A, Jouan V, Urbach S, Samain S, Bergoin M, Wincker P, et al. Analysis of virion structural components reveals vestiges of the ancestral ichnovirus genome. PLoS Pathog. 2010;6:e1000923 pubmed publisher
  17. Serbielle C, Dupas S, Perdereau E, Héricourt F, Dupuy C, Huguet E, et al. Evolutionary mechanisms driving the evolution of a large polydnavirus gene family coding for protein tyrosine phosphatases. BMC Evol Biol. 2012;12:253 pubmed publisher
    ..The gene family which encodes protein tyrosine phosphatases (PTPs) has undergone spectacular expansion in several PDV genomes with up to 42 genes...
  18. Bai S, Cai D, Li X, Chen X. Parasitic castration of Plutella xylostella larvae induced by polydnaviruses and venom of Cotesia vestalis and Diadegma semiclausum. Arch Insect Biochem Physiol. 2009;70:30-43 pubmed publisher
    ..SDS-PAGE analysis indicated that synthesis of P 65 and P 67 proteins were clearly inhibited in testes of hosts that were pseudoparasitized by C. vestalis while reduction in synthesis of other proteins was not evident. ..
  19. Kroemer J, Webb B. Divergences in protein activity and cellular localization within the Campoletis sonorensis Ichnovirus Vankyrin family. J Virol. 2006;80:12219-28 pubmed
    ..Insect cells infected with these viruses exhibited enhanced longevity compared to those infected with viruses expressing other vankyrins. Together, these data suggest that vankyrin proteins in CsIV have divergent physiological functions...
  20. Stoltz D, Lapointe R, Makkay A, Cusson M. Exposure of ichnovirus particles to digitonin leads to enhanced infectivity and induces fusion from without in an in vitro model system. J Gen Virol. 2007;88:2977-84 pubmed
  21. Pruijssers A, Strand M. PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal adhesions and are antiphagocytic in insect immune cells. J Virol. 2007;81:1209-19 pubmed
    Viruses in the family Polydnaviridae are symbiotically associated with parasitoid wasps...
  22. Cui L, Webb B. Homologous sequences in the Campoletis sonorensis polydnavirus genome are implicated in replication and nesting of the W segment family. J Virol. 1997;71:8504-13 pubmed
  23. Belle E, Beckage N, Rousselet J, Poirié M, Lemeunier F, Drezen J. Visualization of polydnavirus sequences in a parasitoid wasp chromosome. J Virol. 2002;76:5793-6 pubmed
  24. Tanaka K, Matsumoto H, Hayakawa Y. Detailed characterization of polydnavirus immunoevasive proteins in an endoparasitoid wasp. Eur J Biochem. 2002;269:2557-66 pubmed
    ..These data suggest that the expression pattern and localization of IEPs are different from other components of CkPDV virions...
  25. Drezen J, Provost B, Espagne E, Cattolico L, Dupuy C, Poirie M, et al. Polydnavirus genome: integrated vs. free virus. J Insect Physiol. 2003;49:407-17 pubmed
    ..Molecular mechanisms already identified could be involved in the acquisition and loss of genes by the PDV genomes and lead us to speculate on the definition of the virus genome...
  26. Asgari S, Schmidt O. Isolation of an imaginal disc growth factor homologue from Pieris rapae and its expression following parasitization by Cotesia rubecula. J Insect Physiol. 2004;50:687-94 pubmed publisher
    ..rapae IDGF is not affected by parasitization and polydnavirus infection. However, the amount of highly expressed genes, such as storage proteins, arylphorin and lipophorin, are significantly reduced following parasitization...
  27. Barat Houari M, Hilliou F, Jousset F, Sofer L, Deleury E, Rocher J, et al. Gene expression profiling of Spodoptera frugiperda hemocytes and fat body using cDNA microarray reveals polydnavirus-associated variations in lepidopteran host genes transcript levels. BMC Genomics. 2006;7:160 pubmed
    ..In this study, we analyzed transcriptional variations in the two main effectors of the insect immune response, the hemocytes and the fat body, after injection of filter-purified HdIV...
  28. Tanaka K, Tsuzuki S, Matsumoto H, Hayakawa Y. Expression of Cotesia kariyai polydnavirus genes in lepidopteran hemocytes and Sf9 cells. J Insect Physiol. 2003;49:433-40 pubmed
    ..8 and CkV0.9 were gradually decreased after reaching the maximum level at 4 h after parasitization. However, the expression of CkV2.0 continues to be increased at least for 10 h after parasitization...
  29. Federici B, Bigot Y. Origin and evolution of polydnaviruses by symbiogenesis of insect DNA viruses in endoparasitic wasps. J Insect Physiol. 2003;49:419-32 pubmed
    ..These particles are defined as virions that belong to viruses of the two genera that comprise the family Polydnaviridae, bracoviruses (genus Bracovirus) transmitted by braconid wasps, and ichnoviruses (genus Ichnovirus) ..
  30. Le N, Asgari S, Amaya K, Tan F, Beckage N. Persistence and expression of Cotesia congregata polydnavirus in host larvae of the tobacco hornworm, Manduca sexta. J Insect Physiol. 2003;49:533-43 pubmed
  31. Kim Y. Identification of host translation inhibitory factor of Campoletis sonorensis ichnovirus on the tobacco budworm, Heliothis virescens. Arch Insect Biochem Physiol. 2005;59:230-44 pubmed
    ..virescens. These results indicate that both cys-motif proteins of VHv 1.4 and VHv 1.1 play a role as HTIF in C. sonorensis parasitization...
  32. Wyder S, Tschannen A, Hochuli A, Gruber A, Saladin V, Zumbach S, et al. Characterization of Chelonus inanitus polydnavirus segments: sequences and analysis, excision site and demonstration of clustering. J Gen Virol. 2002;83:247-56 pubmed
    ..A model to illustrate where the terminal repeats might recombine to yield the circular molecule is presented. Excision of CiV12 and CiV14 is restricted to the female and sets in at a very specific time-point in pupal-adult development...
  33. Dupuy C, Periquet G, Serbielle C, Bézier A, Louis F, Drezen J. Transfer of a chromosomal Maverick to endogenous bracovirus in a parasitoid wasp. Genetica. 2011;139:489-96 pubmed publisher
    ..The presence of the Maverick in a bracovirus genome suggests the possibility of transposon transfers from parasitoids to lepidoptera via bracoviruses...
  34. Rasoolizadeh A, Béliveau C, Stewart D, Cloutier C, Cusson M. Tranosema rostrale ichnovirus repeat element genes display distinct transcriptional patterns in caterpillar and wasp hosts. J Gen Virol. 2009;90:1505-14 pubmed publisher
    ..rostrale head-thorax complexes, whereas some were abundant in ovaries. There, the transcription pattern was completely different from that observed in infected caterpillars, suggesting that some rep genes have wasp-specific functions...
  35. Marti D, Grossniklaus Bürgin C, Wyder S, Wyler T, Lanzrein B. Ovary development and polydnavirus morphogenesis in the parasitic wasp Chelonus inanitus. I. Ovary morphogenesis, amplification of viral DNA and ecdysteroid titres. J Gen Virol. 2003;84:1141-50 pubmed
    ..As copy numbers of excised circular viral DNA and rejoined flanking DNA reached similarly high levels, excised viral DNA appeared not to replicate. After adult eclosion, amplification of viral DNA declined...
  36. Bézier A, Herbinière J, Serbielle C, Lesobre J, Wincker P, Huguet E, et al. Bracovirus gene products are highly divergent from insect proteins. Arch Insect Biochem Physiol. 2008;67:172-87 pubmed publisher
    ..We discuss how this divergence might be explained in the context of the current hypotheses on the origin and evolution of wasp-bracovirus associations...
  37. Barandoc K, Kim J, Kim Y. Cotesia plutellae bracovirus suppresses expression of an antimicrobial peptide, cecropin, in the diamondback moth, Plutella xylostella, challenged by bacteria. J Microbiol. 2010;48:117-23 pubmed publisher
    ..These results indicate that PxCec expression is regulated by both immune and developmental processes in P. xylostella. The parasitization by C. plutellae inhibited the expression of PxCec by the wasp's symbiotic virus...
  38. Espagne E, Dupuy C, Huguet E, Cattolico L, Provost B, Martins N, et al. Genome sequence of a polydnavirus: insights into symbiotic virus evolution. Science. 2004;306:286-9 pubmed
  39. Falabella P, Varricchio P, Provost B, Espagne E, Ferrarese R, Grimaldi A, et al. Characterization of the IkappaB-like gene family in polydnaviruses associated with wasps belonging to different Braconid subfamilies. J Gen Virol. 2007;88:92-104 pubmed
    ..Altogether, these results suggest strongly that TnBV ANK proteins cause retention of NF-kappaB/Rel factors in the cytoplasm and may thus contribute to suppression of the immune response in parasitized host larvae...
  40. Choi J, Roh J, Kang J, Shim H, Woo S, Jin B, et al. Genomic segments cloning and analysis of Cotesia plutellae polydnavirus using plasmid capture system. Biochem Biophys Res Commun. 2005;332:487-93 pubmed
    ..Interestingly, 9 of 10 putative ORFs had high level of similarities with catalytic domain of protein tyrosine phosphatase. Also, ORF2807 showed similarity with EP1-like proteins of C. congregata polydnavirus...
  41. Kaeslin M, Pfister Wilhelm R, Lanzrein B. Influence of the parasitoid Chelonus inanitus and its polydnavirus on host nutritional physiology and implications for parasitoid development. J Insect Physiol. 2005;51:1330-9 pubmed
  42. Schmidt O, Glatz R, Asgari S, Roberts H. Are insect immune suppressors driving cellular uptake reactions?. Arch Insect Biochem Physiol. 2005;60:153-8 pubmed
  43. Webb B, Strand M, Dickey S, Beck M, Hilgarth R, Barney W, et al. Polydnavirus genomes reflect their dual roles as mutualists and pathogens. Virology. 2006;347:160-74 pubmed
    ..The Polydnaviridae is a family of double-stranded (ds) DNA viruses associated with parasitoid wasps that parasitize other insects...
  44. Hepat R, Kim Y. Transient expression of a viral histone H4 inhibits expression of cellular and humoral immune-associated genes in Tribolium castaneum. Biochem Biophys Res Commun. 2011;415:279-83 pubmed publisher
    ..These results suggest that CpBV-H4 suppresses both humoral and cellular immune responses of T. castaneum by altering a normal epigenetic control of immune-associated gene expression...
  45. Beck M, Zhang S, Bitra K, Burke G, Strand M. The encapsidated genome of Microplitis demolitor bracovirus integrates into the host Pseudoplusia includens. J Virol. 2011;85:11685-96 pubmed publisher
    ..The presence of HIMs in most MdBV genomic DNAs suggests that the integration of each genomic segment into host cells occurs through a shared mechanism...
  46. Kroemer J, Webb B. Polydnavirus genes and genomes: emerging gene families and new insights into polydnavirus replication. Annu Rev Entomol. 2004;49:431-56 pubmed
    ..However, sequencing of these viral genomes has been informative and provides opportunities for productive investigation of these unusual mutualistic insect viruses...
  47. Gundersen Rindal D, Pedroni M. Larval stage Lymantria dispar microRNAs differentially expressed in response to parasitization by Glyptapanteles flavicoxis parasitoid. Arch Virol. 2010;155:783-7 pubmed publisher
    ..Certain cellular miRNAs were differentially expressed in larval tissues, such as the potentially developmentally linked mir-277, signifying a need for functional studies...
  48. Barandoc K, Kim Y. Translation inhibitory factors encoded in Cotesia plutellae bracovirus require the 5'-UTR of a host mRNA target. Comp Biochem Physiol B Biochem Mol Biol. 2010;156:129-36 pubmed publisher
    ..This study suggests that CpBV15alpha and CpBV15beta inhibit host mRNAs directly by acting on translation machinery, in which 5'-UTR of target mRNAs would be required for the inhibitory action...
  49. Volkoff A, Beliveau C, Rocher J, Hilgarth R, Levasseur A, Duonor Cerutti M, et al. Evidence for a conserved polydnavirus gene family: ichnovirus homologs of the CsIV repeat element genes. Virology. 2002;300:316-31 pubmed
    ..The finding that repeat element genes form an interspecific family within the genus Ichnovirus supports the view that the proteins they encode play an important role in ichnovirus biology...
  50. Labrosse C, Carton Y, Dubuffet A, Drezen J, Poirie M. Active suppression of D. melanogaster immune response by long gland products of the parasitic wasp Leptopilina boulardi. J Insect Physiol. 2003;49:513-22 pubmed
    ..boulardi and L. heterotoma differ in several respects, suggesting that different physiological strategies of immunosuppression might be used by specialised and generalist parasitoids...
  51. Annaheim M, Lanzrein B. Genome organization of the Chelonus inanitus polydnavirus: excision sites, spacers and abundance of proviral and excised segments. J Gen Virol. 2007;88:450-7 pubmed
    ..Measurement of relative abundances of various segments in proviral and excised form indicates for the first time that abundant segments are present in multiple copies in the proviral form...
  52. Burke G, Strand M. Deep sequencing identifies viral and wasp genes with potential roles in replication of Microplitis demolitor Bracovirus. J Virol. 2012;86:3293-306 pubmed publisher
    Viruses in the genus Bracovirus (BV) (Polydnaviridae) are symbionts of parasitoid wasps that specifically replicate in the ovaries of females...
  53. Cusson M, Laforge M, Miller D, Cloutier C, Stoltz D. Functional significance of parasitism-induced suppression of juvenile hormone esterase activity in developmentally delayed Choristoneura fumiferana larvae. Gen Comp Endocrinol. 2000;117:343-54 pubmed
    ..In view of the latter observation, we put forward three hypotheses regarding the functional significance of the observed suppression of JHE activity in developmentally arrested C. fumiferana larvae...
  54. Wetterwald C, Roth T, Kaeslin M, Annaheim M, Wespi G, Heller M, et al. Identification of bracovirus particle proteins and analysis of their transcript levels at the stage of virion formation. J Gen Virol. 2010;91:2610-9 pubmed publisher
    ..These data confirm the important contribution of nudivirus genes but also indicate the presence of many lineage- or species-specific proteins possibly involved in the parasitoid-host interaction...
  55. Drezen J, Bézier A, Lesobre J, Huguet E, Cattolico L, Periquet G, et al. The few virus-like genes of Cotesia congregata bracovirus. Arch Insect Biochem Physiol. 2006;61:110-22 pubmed
    ..We discuss the significance of the scarce homology found between proteins from CcBV and other viruses or mobile elements...
  56. Gundersen Rindal D, Lynn D. Polydnavirus integration in lepidopteran host cells in vitro. J Insect Physiol. 2003;49:453-62 pubmed
    ..A potential mechanism is proposed for the integration of PDV DNA in vitro. It remains to be seen if integration of the virus also occurs in the lepidopteran host in vivo...
  57. Tian S, Zhang J, Wang C. Cloning and characterization of two Campoletis chlorideae ichnovirus vankyrin genes expressed in parasitized host Helicoverpa armigera. J Insect Physiol. 2007;53:699-707 pubmed
  58. Asgari S. Venom proteins from polydnavirus-producing endoparasitoids: their role in host-parasite interactions. Arch Insect Biochem Physiol. 2006;61:146-56 pubmed
    ..rubecula venom proteins in host-parasitoid interactions...
  59. Gad W, Kim Y. A viral histone H4 encoded by Cotesia plutellae bracovirus inhibits haemocyte-spreading behaviour of the diamondback moth, Plutella xylostella. J Gen Virol. 2008;89:931-8 pubmed publisher
    ..These results suggest that CpBV H4 plays a critical role in suppressing host immune responses during parasitization...
  60. Beck M, Strand M. A novel polydnavirus protein inhibits the insect prophenoloxidase activation pathway. Proc Natl Acad Sci U S A. 2007;104:19267-72 pubmed publisher
    ..Overall, our results identify a novel inhibitor of the PO cascade and indicate that suppression of the host melanization response is functionally important for both the virus and its associated wasp...
  61. Bigot Y, Samain S, Augé Gouillou C, Federici B. Molecular evidence for the evolution of ichnoviruses from ascoviruses by symbiogenesis. BMC Evol Biol. 2008;8:253 pubmed publisher
    ..Structural similarities between ascovirus and ichnovirus particles and the biology of their transmission suggest that ichnoviruses evolved from ascoviruses, although molecular evidence for this hypothesis is lacking...
  62. Eum J, Bottjen R, Pruijssers A, Clark K, Strand M. Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus. Insect Biochem Mol Biol. 2010;40:690-8 pubmed publisher
    ..Overall, our results indicate that PTP-H2 is a functional tyrosine phosphatase that is specifically expressed in MdBV-infected hemocytes...
  63. Beckage N, Gelman D. Wasp parasitoid disruption of host development: implications for new biologically based strategies for insect control. Annu Rev Entomol. 2004;49:299-330 pubmed
    ..Possibilities for using regulatory molecules produced by the parasitoid or its products that would be potentially useful in developing new, environmentally safe insect control agents are discussed...
  64. Turnbull M, Volkoff A, Webb B, Phelan P. Functional gap junction genes are encoded by insect viruses. Curr Biol. 2005;15:R491-2 pubmed
  65. Kaeslin M, Reinhard M, Bühler D, Roth T, Pfister Wilhelm R, Lanzrein B. Venom of the egg-larval parasitoid Chelonus inanitus is a complex mixture and has multiple biological effects. J Insect Physiol. 2010;56:686-94 pubmed publisher
    ..The multifunctionality of the venom might thus be essential in enabling parasitization of all stages of host eggs...
  66. Glatz R, Schmidt O, Asgari S. Characterization of a novel protein with homology to C-type lectins expressed by the Cotesia rubecula bracovirus in larvae of the lepidopteran host, Pieris rapae. J Biol Chem. 2003;278:19743-50 pubmed
    ..The high similarity of CrV3 with invertebrate lectins, as opposed to those from viruses, may indicate that some bracovirus functions were acquired from their hosts...
  67. Gitau C, Gundersen Rindal D, Pedroni M, Mbugi P, Dupas S. Differential expression of the CrV1 haemocyte inactivation-associated polydnavirus gene in the African maize stem borer Busseola fusca (Fuller) parasitized by two biotypes of the endoparasitoid Cotesia sesamiae (Cameron). J Insect Physiol. 2007;53:676-84 pubmed
    ..Non synonymous difference in CrV1 gene sequences between virulent and avirulent wasp suggests that variations in B. fusca parasitism by C. sesamiae may be due to qualitative differences in CrV1-haemocyte interactions...
  68. Bitra K, Suderman R, Strand M. Polydnavirus Ank proteins bind NF-?B homodimers and inhibit processing of Relish. PLoS Pathog. 2012;8:e1002722 pubmed publisher
    ..Overall, our data provide the first quantitative measures of insect and viral I?B binding affinities, while also showing that viral mimics disable Relish processing...
  69. Desjardins C, Gundersen Rindal D, Hostetler J, Tallon L, Fuester R, Schatz M, et al. Structure and evolution of a proviral locus of Glyptapanteles indiensis bracovirus. BMC Microbiol. 2007;7:61 pubmed
    ..Here we describe a 223 kbp region of Glyptapanteles indiensis genomic DNA which contains a part of the G. indiensis bracovirus (GiBV) proviral genome...
  70. Provost B, Varricchio P, Arana E, Espagne E, Falabella P, Huguet E, et al. Bracoviruses contain a large multigene family coding for protein tyrosine phosphatases. J Virol. 2004;78:13090-103 pubmed
    ..One protein tyrosine phosphatase is a functional phosphatase. These results strengthen the hypothesis that protein tyrosine phosphatases are involved in virally induced alterations of host physiology during parasitism...
  71. Bitra K, Zhang S, Strand M. Transcriptomic profiling of Microplitis demolitor bracovirus reveals host, tissue and stage-specific patterns of activity. J Gen Virol. 2011;92:2060-71 pubmed publisher
    ..demolitor, albeit at much lower levels than in P. includens. However, another encapsidated gene (orph-B1) was expressed in adult M. demolitor at similar levels to those detected in P. includens...
  72. Galibert L, Rocher J, Ravallec M, Duonor Cerutti M, Webb B, Volkoff A. Two Hyposoter didmator ichnovirus genes expressed in the lepidopteran host encode secreted or membrane-associated serine and threonine rich proteins in segments that may be nested. J Insect Physiol. 2003;49:441-51 pubmed
    ..Each of these repeats contains 58% of serine and threonine residues and therefore several potential sites for glycosylation. This mucin-like protein, predicted as highly glycosylated, could be involved in host immune suppression...
  73. Beliveau C, Levasseur A, Stoltz D, Cusson M. Three related TrIV genes: comparative sequence analysis and expression in host larvae and Cf-124T cells. J Insect Physiol. 2003;49:501-11 pubmed
    ..i. This in vitro system may provide a suitable starting point for the study of TrIV gene functions...
  74. Suderman R, Pruijssers A, Strand M. Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells. J Gen Virol. 2008;89:1411-20 pubmed publisher
    The family Polydnaviridae is a large group of immunosuppressive insect viruses that are symbiotically associated with parasitoid wasps...
  75. Rattanadechakul W, Webb B. Characterization of Campoletis sonorensis ichnovirus unique segment B and excision locus structure. J Insect Physiol. 2003;49:523-32 pubmed
    ..The data indicate that Ichnovirus segments have distinctive characteristics possibly reflecting functional co-evolution between the wasp and individual types of polydnavirus segments...
  76. Gad W, Kim Y. N-terminal tail of a viral histone H4 encoded in Cotesia plutellae bracovirus is essential to suppress gene expression of host histone H4. Insect Mol Biol. 2009;18:111-8 pubmed publisher
    ..This study suggests that the viral H4 encoded in CpBV can alter host gene expression with its extended N-terminal tail...
  77. Beck M, Strand M. Glc1.8 from Microplitis demolitor bracovirus induces a loss of adhesion and phagocytosis in insect high five and S2 cells. J Virol. 2005;79:1861-70 pubmed
    b>Polydnaviridae is a unique family of DNA viruses that are symbiotically associated with parasitoid wasps...
  78. Chen Y, Gao F, Ye X, Wei S, Shi M, Zheng H, et al. Deep sequencing of Cotesia vestalis bracovirus reveals the complexity of a polydnavirus genome. Virology. 2011;414:42-50 pubmed publisher
    ..Strikingly, we identified a putative helicase protein displaying similarity to human Pif1 helicase, which has never been reported for other PDVs. This finding will bring new insights in research of these special viruses...
  79. Pfister Wilhelm R, Lanzrein B. Stage dependent influences of polydnaviruses and the parasitoid larva on host ecdysteroids. J Insect Physiol. 2009;55:707-15 pubmed publisher
    ..e. immediately before egression of the parasitoid. In vitro experiments showed that late 2nd instar parasitoids release ecdysteroids and are thus very likely responsible for the rise in host ecdysteroids...
  80. Whitfield J, Asgari S. Virus or not? Phylogenetics of polydnaviruses and their wasp carriers. J Insect Physiol. 2003;49:397-405 pubmed
    ..Ongoing sequencing studies of entire PDV genomes from diverse wasp species are likely to greatly contribute to our understanding of PDV evolution...