feline panleukopenia virus

Summary

Summary: A species of PARVOVIRUS infecting cats with a highly contagious enteric disease. Host range variants include mink enteritis virus, canine parvovirus (PARVOVIRUS, CANINE), and raccoon parvovirus. After infecting their new hosts, many of these viruses have further evolved and are now considered distinct species.

Top Publications

  1. Kanellos T, Sutton D, Salisbury C, Chalmers W. Combined administration in a single injection of a feline multivalent modified live vaccine against FHV, FCV, and FPLV together with a recombinant FeLV vaccine is both safe and efficacious for all four major feline viral pathogens. J Feline Med Surg. 2008;10:346-54 pubmed publisher
    ..Challenge studies using pathogenic herpesvirus and FeLV revealed no difference in the degree of clinical protection. This paper shows that neither safety nor efficacy is adversely affected as a result of mixing the two vaccines...
  2. Eleraky N, Potgieter L, Kennedy M. Virucidal efficacy of four new disinfectants. J Am Anim Hosp Assoc. 2002;38:231-4 pubmed
    ..The quaternary ammonium compound evaluated in this study and citricidal were not effective against feline calicivirus and feline parvovirus...
  3. Mouzin D, Lorenzen M, Haworth J, King V. Duration of serologic response to three viral antigens in cats. J Am Vet Med Assoc. 2004;224:61-6 pubmed
    ..To determine whether vaccinated cats either remained seropositive or responded serologically to revaccination against 3 key viral antigens after extended periods since their last vaccination...
  4. Ramanathan A, Malik P, Prasad G. Seroepizootiological survey for selected viral infections in captive Asiatic lions (Panthera leo persica) from western India. J Zoo Wildl Med. 2007;38:400-8 pubmed
    ..Vaccinations must be considered, using killed or other suitable viral vaccines, which have been proved to be safe, effective, and efficacious in endangered felids...
  5. Yang S, Xia X, Qiao J, Liu Q, Chang S, Xie Z, et al. Complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing VP2 from FPV. Vaccine. 2008;26:1482-7 pubmed publisher
    b>Feline panleukopenia virus (FPV) is an important infectious pathogen of all members of the family Felidae...
  6. Chang S, Sgro J, Parrish C. Multiple amino acids in the capsid structure of canine parvovirus coordinately determine the canine host range and specific antigenic and hemagglutination properties. J Virol. 1992;66:6858-67 pubmed
    Canine parvovirus (CPV) and feline panleukopenia virus (FPV) are over 98% similar in DNA sequence but have specific host range, antigenic, and hemagglutination (HA) properties which were located within the capsid protein gene...
  7. An D, Jeong W, Jeoung H, Yoon S, Kim H, Park J, et al. Phylogenetic analysis of feline panleukopenia virus (FPLV) strains in Korean cats. Res Vet Sci. 2011;90:163-7 pubmed publisher
    Sixteen Korean feline panleukopenia virus (FPLV) strains were compared with 48 non-Korean strains and two vaccine strains to conduct phylogenetic analysis of the FPLVs currently circulating among cats in Korea...
  8. Horiuchi M, Yamaguchi Y, Gojobori T, Mochizuki M, Nagasawa H, Toyoda Y, et al. Differences in the evolutionary pattern of feline panleukopenia virus and canine parvovirus. Virology. 1998;249:440-52 pubmed
    ..Virological and molecular genetic analyses mainly focused on feline panleukopenia virus (FPLV) were conducted in this study because FPLV is the suspected ancestor of CPV; the way in which FPLV ..
  9. Truyen U, Parrish C. Canine and feline host ranges of canine parvovirus and feline panleukopenia virus: distinct host cell tropisms of each virus in vitro and in vivo. J Virol. 1992;66:5399-408 pubmed
    ..The origin of CPV is unknown, but a variation from feline panleukopenia virus (FPV) or another closely related parvovirus is suspected...

More Information

Publications87

  1. Hueffer K, Parker J, Weichert W, Geisel R, Sgro J, Parrish C. The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor. J Virol. 2003;77:1718-26 pubmed
    ..and an intermediate virus strain (CPV type 2) bound to higher levels on cells than did either the feline panleukopenia virus or a later strain of CPV...
  2. Yang S, Wang S, Feng H, Zeng L, Xia Z, Zhang R, et al. Isolation and characterization of feline panleukopenia virus from a diarrheic monkey. Vet Microbiol. 2010;143:155-9 pubmed publisher
    A feline panleukopenia virus (FPV) mutant, monkey/BJ-22/2008/CHN, was isolated from intestinal contents of a diarrheic monkey in Beijing, China...
  3. Agbandje M, McKenna R, Rossmann M, Strassheim M, Parrish C. Structure determination of feline panleukopenia virus empty particles. Proteins. 1993;16:155-71 pubmed
    Various crystal forms of the single-stranded DNA, feline panleukopenia virus (FPV), a parvovirus, have been grown of both full virions and empty particles...
  4. Miyazawa T, Ikeda Y, Nakamura K, Naito R, Mochizuki M, Tohya Y, et al. Isolation of feline parvovirus from peripheral blood mononuclear cells of cats in northern Vietnam. Microbiol Immunol. 1999;43:609-12 pubmed
  5. Parrish C. Mapping specific functions in the capsid structure of canine parvovirus and feline panleukopenia virus using infectious plasmid clones. Virology. 1991;183:195-205 pubmed
    DNA sequences between 0 and 98.8 genome map units (m.u.) from canine parvovirus (CPV) and feline panleukopenia virus (FPV) were cloned into plasmid vectors to form infectious molecular clones...
  6. Martyn J, Davidson B, Studdert M. Nucleotide sequence of feline panleukopenia virus: comparison with canine parvovirus identifies host-specific differences. J Gen Virol. 1990;71 ( Pt 11):2747-53 pubmed
    The nucleotide sequence of feline panleukopenia virus (FPV) strain 193 was determined and compared with the sequence of canine parvovirus (CPV) strain N and partial sequences of FPV strain Carl and CPV strain b...
  7. Ikeda Y, Miyazawa T, Nakamura K, Naito R, Inoshima Y, Tung K, et al. Serosurvey for selected virus infections of wild carnivores in Taiwan and Vietnam. J Wildl Dis. 1999;35:578-81 pubmed
    ..All civets and nine of 11 leopard cats were shown to have antibodies against feline parvovirus (FPV), and FPV's were isolated from mononuclear cells in the peripheral blood of the six leopard cats...
  8. Schunck B, Kraft W, Truyen U. A simple touch-down polymerase chain reaction for the detection of canine parvovirus and feline panleukopenia virus in feces. J Virol Methods. 1995;55:427-33 pubmed
    ..The very rapid and simple sample preparation recommends this PCR assay as an alternative technique for routine parvovirus diagnosis...
  9. Lappin M, Veir J, Hawley J. Feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus antibody responses in seronegative specific pathogen-free cats after a single administration of two different modified live FVRCP vaccines. J Feline Med Surg. 2009;11:159-62 pubmed publisher
    Two groups of feline panleukopenia virus (FPV), feline calicivirus (FCV), and feline herpesvirus-1 (FHV-1) seronegative cats (five cats per group) were administered one of two modified live feline viral rhinotracheitis, calicivirus, and ..
  10. Truyen U, Geissler K, Parrish C, Hermanns W, Siegl G. No evidence for a role of modified live virus vaccines in the emergence of canine parvovirus. J Gen Virol. 1998;79 ( Pt 5):1153-8 pubmed
    ..sequenced the VP2 capsid protein genes of three German CPV strains isolated in 1979-1980, as well as two feline panleukopenia virus (FPV) vaccine viruses that were previously shown to have some restriction enzyme cleavage sites in ..
  11. Veijalainen P. Characterization of biological and antigenic properties of raccoon dog and blue fox parvoviruses: a monoclonal antibody study. Vet Microbiol. 1988;16:219-30 pubmed
    ..Raccoon dog parvovirus, while resembling CPV, had a unique antigenic site which could be specified by MAbs. The pattern of MAbs prepared against blue fox parvovirus indicated that it is a member of Type 2 MEV...
  12. Lutz H, Castelli I, Ehrensperger F, Pospischil A, Rosskopf M, Siegl G, et al. Panleukopenia-like syndrome of FeLV caused by co-infection with FeLV and feline panleukopenia virus. Vet Immunol Immunopathol. 1995;46:21-33 pubmed
    ..No feline panleukopenia virus (FPLV) antigen was found in feces by latex agglutination, enzyme-linked immunosorbent assay (ELISA) or ..
  13. Ohshima T, Mochizuki M. Evidence for recombination between feline panleukopenia virus and canine parvovirus type 2. J Vet Med Sci. 2009;71:403-8 pubmed
    ..parvovirus type 2 (CPV) is a virulent pathogen that emerged in the late 1970s, probably originating from feline panleukopenia virus (FPLV) or a closely related carnivore parvovirus belonging to the feline parvovirus (FPV) subspecies...
  14. Duarte M, Barros S, Henriques M, Fernandes T, Bernardino R, Monteiro M, et al. Fatal infection with feline panleukopenia virus in two captive wild carnivores (Panthera tigris and Panthera leo). J Zoo Wildl Med. 2009;40:354-9 pubmed
    ..VP2 complete gene was achieved in both cases and sequencing analysis identified these isolates as feline panleukopenia virus (FPLV). The nucleotide sequences obtained from these two viruses were genetically indistinguishable...
  15. Gore T, Lakshmanan N, Williams J, Jirjis F, Chester S, Duncan K, et al. Three-year duration of immunity in cats following vaccination against feline rhinotracheitis virus, feline calicivirus, and feline panleukopenia virus. Vet Ther. 2006;7:213-22 pubmed
    ..feline calicivirus (FCV) or sequentially challenged with feline rhinotracheitis virus (FRV) followed by feline panleukopenia virus (FPV)...
  16. Decaro N, Desario C, Miccolupo A, Campolo M, Parisi A, Martella V, et al. Genetic analysis of feline panleukopenia viruses from cats with gastroenteritis. J Gen Virol. 2008;89:2290-8 pubmed publisher
    ..All viruses were proven to be true feline panleukopenia virus (FPLV) strains by a minor groove binder probe assay, which is able to discriminate between FPLV and the ..
  17. Parrish C, Leathers C, Pearson R, Gorham J. Comparisons of feline panleukopenia virus, canine parvovirus, raccoon parvovirus, and mink enteritis virus and their pathogenicity for mink and ferrets. Am J Vet Res. 1987;48:1429-35 pubmed
    Parvoviruses from mink (mink enteritis virus [MEV]), cats (feline panleukopenia virus [FPV]), raccoons (raccoon parvovirus [RPV]), and dogs (canine parvovirus [CPV]) were compared...
  18. Hoelzer K, Shackelton L, Parrish C, Holmes E. Phylogenetic analysis reveals the emergence, evolution and dispersal of carnivore parvoviruses. J Gen Virol. 2008;89:2280-9 pubmed publisher
    ..CPV emerged from the endemic feline panleukopenia virus (FPV), or from a closely related parvovirus of another host...
  19. Nakamura K, Ikeda Y, Miyazawa T, Tohya Y, Takahashi E, Mochizuki M. Characterisation of cross-reactivity of virus neutralising antibodies induced by feline panleukopenia virus and canine parvoviruses. Res Vet Sci. 2001;71:219-22 pubmed
    ..It is important to determine whether conventional feline panleukopenia virus (FPLV) vaccines protect against recent CPV infections...
  20. Ikeda Y, Nakamura K, Miyazawa T, Takahashi E, Mochizuki M. Feline host range of canine parvovirus: recent emergence of new antigenic types in cats. Emerg Infect Dis. 2002;8:341-6 pubmed
    ..Recent investigations demonstrate the prevalence of CPV-2a and 2b infection in a wide range of cat populations. We illustrate the pathogenic potential of CPV in cats and assess the risk caused by CPV variants...
  21. Sassa Y, Yamamoto H, Mochizuki M, Umemura T, Horiuchi M, Ishiguro N, et al. Successive deaths of a captive snow leopard (Uncia uncia) and a serval (Leptailurus serval) by infection with feline panleukopenia virus at Sapporo Maruyama Zoo. J Vet Med Sci. 2011;73:491-4 pubmed
    ..Isolates possessed an antigenic epitope for both the feline panleukopenia virus (FPLV) and mink enteritis virus, identified with a hemagglutination inhibition test...
  22. Hoelzer K, Shackelton L, Holmes E, Parrish C. Within-host genetic diversity of endemic and emerging parvoviruses of dogs and cats. J Virol. 2008;82:11096-105 pubmed publisher
    ..population structures during natural infections of animals with canine parvovirus (CPV) or its ancestor, feline panleukopenia virus (FPV)...
  23. Palermo L, Hafenstein S, Parrish C. Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges. J Virol. 2006;80:8482-92 pubmed
    The cell infection processes and host ranges of canine parvovirus (CPV) and feline panleukopenia virus (FPV) are controlled by their capsid interactions with the transferrin receptors (TfR) on their host cells...
  24. Franzo G, Tucciarone C, Cecchinato M, Drigo M. Canine parvovirus type 2 (CPV-2) and Feline panleukopenia virus (FPV) codon bias analysis reveals a progressive adaptation to the new niche after the host jump. Mol Phylogenet Evol. 2017;114:82-92 pubmed publisher
    ..was selected as a model because it represents a well characterized case of host jump, originating from Feline panleukopenia virus (FPV)...
  25. Chaber A, Cozzi G, Broekhuis F, Hartley R, W McNutt J. Serosurvey for Selected Viral Pathogens among Sympatric Species of the African Large Predator Guild in Northern Botswana. J Wildl Dis. 2017;53:170-175 pubmed publisher
    ..Samples were tested for antibodies against canine distemper virus (CDV), feline panleukopenia virus, enteric coronavirus, feline calicivirus, feline herpesvirus (FHV-1), and feline immunodeficiency virus (..
  26. Horiuchi M, Ishiguro N, Goto H, Shinagawa M. Characterization of the stage(s) in the virus replication cycle at which the host-cell specificity of the feline parvovirus subgroup is regulated in canine cells. Virology. 1992;189:600-8 pubmed
    b>Feline panleukopenia virus (FPLV), mink enteritis virus (MEV), and canine parvovirus (CPV) are classified as a host-range variants. They show different host-range specificity in vivo and host-cell specificity in vitro...
  27. Patterson E, Reese M, Tucker S, Dubovi E, Crawford P, Levy J. Effect of vaccination on parvovirus antigen testing in kittens. J Am Vet Med Assoc. 2007;230:359-63 pubmed
    To determine the frequency and duration of feline panleukopenia virus (FPV) vaccine-induced interference with fecal parvovirus diagnostic testing in cats.
  28. Lappin M, Jensen W, Jensen T, Basaraba R, Brown C, Radecki S, et al. Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats. Am J Vet Res. 2005;66:506-11 pubmed
    ..Hypersensitization with CRFK cell proteins did not result in renal disease in cats during the 56-week study. ..
  29. Clegg S, Coyne K, Dawson S, Spibey N, Gaskell R, Radford A. Canine parvovirus in asymptomatic feline carriers. Vet Microbiol. 2012;157:78-85 pubmed publisher
  30. Blanco K, Prendas J, Cortes R, Jimenez C, Dolz G. Seroprevalence of viral infections in domestic cats in Costa Rica. J Vet Med Sci. 2009;71:661-3 pubmed
    ..Antibodies against FIV were detected in 8.8% of the samples tested; 8 (88.8%) of the seropositive cats were older than 1 year of age, and a greater proportion of seropositive males (66.6%) was found. ..
  31. Vermeulen B, Gleich S, Dedeurwaerder A, Olyslaegers D, Desmarets L, Dewerchin H, et al. In vitro assessment of the feline cell-mediated immune response against feline panleukopeniavirus, calicivirus and felid herpesvirus 1 using 5-bromo-2'-deoxyuridine labeling. Vet Immunol Immunopathol. 2012;146:177-84 pubmed publisher
    ..proliferation responses were quantified upon in vitro restimulation with inactivated and infectious feline panleukopenia virus (FPV), feline calicivirus (FCV) and felid herpesvirus 1 (FeHV-1)...
  32. Wosu L. Feline panleucopenia--in vivo infectivity studies. Vet Microbiol. 1988;16:137-43 pubmed
    ..No clinical disease was produced. However, cats infected with "full" particles developed antibody more rapidly than cats infected with the other particles. ..
  33. Löfling J, Lyi S, Parrish C, Varki A. Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid. Virology. 2013;440:89-96 pubmed publisher
    b>Feline panleukopenia virus (FPV) is a pathogen whose canine-adapted form (canine parvovirus (CPV)) emerged in 1978. These viruses infect by binding host transferrin receptor type-1 (TfR), but also hemagglutinate erythrocytes...
  34. Jas D, Aeberle C, Lacombe V, Guiot A, Poulet H. Onset of immunity in kittens after vaccination with a non-adjuvanted vaccine against feline panleucopenia, feline calicivirus and feline herpesvirus. Vet J. 2009;182:86-93 pubmed publisher
    ..Following the 1-week challenge, excretion of FPV, FHV and FCV was significantly reduced in vaccinated cats compared to control kittens, confirming the onset of immunity within 7 days of vaccination. ..
  35. Streck A, Rüster D, Truyen U, Homeier T. An updated TaqMan real-time PCR for canine and feline parvoviruses. J Virol Methods. 2013;193:6-8 pubmed publisher
    Canine parvovirus type 2 (CPV-2) emerged in late 1970s from the feline panleukopenia virus (FPLV) and developed, since then, into novel genetic and antigenic variants (CPV-2a, -2b and -2c)...
  36. Hueffer K, Palermo L, Parrish C. Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains. J Virol. 2004;78:5601-11 pubmed
    ..These chimeric receptors bound CPV capsids and mediated uptake but did not result in cell infection. Adding soluble feline TfR ectodomain to the virus during that uptake did not allow infection. ..
  37. Waldvogel A, Hassam S, Stoerckle N, Weilenmann R, Tratschin J, Siegl G, et al. Specific diagnosis of parvovirus enteritis in dogs and cats by in situ hybridization. J Comp Pathol. 1992;107:141-6 pubmed
    ..Demonstration of the infectious agent by in situ hybridization, however, proves to be a valuable specific tool which allows an exact cellular localization of parvovirus in formalin-fixed, paraffin wax-embedded tissue sections. ..
  38. Lappin M. Feline panleukopenia virus, feline herpesvirus-1 and feline calicivirus antibody responses in seronegative specific pathogen-free kittens after parenteral administration of an inactivated FVRCP vaccine or a modified live FVRCP vaccine. J Feline Med Surg. 2012;14:161-4 pubmed publisher
    ..There were no statistical differences between the serological response rates between the two FVRCP vaccines in regard to FCV...
  39. Harrison T, Mazet J, Holekamp K, Dubovi E, Engh A, Nelson K, et al. Antibodies to canine and feline viruses in spotted hyenas (Crocuta crocuta) in the Masai Mara National Reserve. J Wildl Dis. 2004;40:1-10 pubmed
    ..Antibodies to canine distemper virus (CDV), feline immunodeficiency virus (FIV), feline panleukopenia virus/canine parvovirus (FPLV/CPV), feline coronavirus/ feline infectious peritonitis virus (FECV/IPV), feline ..
  40. Hellard E, Fouchet D, Santin Janin H, Tarin B, Badol V, Coupier C, et al. When cats' ways of life interact with their viruses: a study in 15 natural populations of owned and unowned cats (Felis silvestris catus). Prev Vet Med. 2011;101:250-64 pubmed publisher
  41. Ruch Gallie R, Veir J, Hawley J, Lappin M. Results of molecular diagnostic assays targeting feline herpesvirus-1 and feline calicivirus in adult cats administered modified live vaccines. J Feline Med Surg. 2011;13:541-5 pubmed publisher
    ..9%) prior to vaccination and 7/12 cats (12/154 samples; 7.8%) after vaccination. Positive molecular diagnostic assay results for FHV-1 and FCV were uncommon prior to or after vaccination in these cats...
  42. Hueffer K, Truyen U, Parrish C. [Evolution and host variation of the canine parvovirus: molecular basis for the development of a new virus]. Berl Munch Tierarztl Wochenschr. 2004;117:130-5 pubmed
    Canine parvovirus (CPV) evolved as a new pathogen in dogs between 1976 and 1978 from feline panleukopenia virus (FPV)...
  43. Canuti M, Rodrigues B, Whitney H, Lang A. Introduction of canine parvovirus 2 into wildlife on the Island of Newfoundland, Canada. Infect Genet Evol. 2017;55:205-208 pubmed publisher
    Canine parvovirus-2 (CPV-2) and feline panleukopenia virus (FPV) (species Carnivore protoparvovirus 1, family Parvoviridae) cause a severe gastrointestinal disease associated with immune depression in a broad range of terrestrial ..
  44. Starr R. Reaction rate in cats vaccinated with a new controlled-titer feline panleukopenia-rhinotracheitis-calicivirus-Chlamydia psittaci vaccine. Cornell Vet. 1993;83:311-23 pubmed
    ..02% of cats receiving the comparison vaccine. The difference was not statistically significant (P = 0.45). Reaction rate of the controlled-titer vaccine and that of the vaccine currently accepted by veterinarians appear to be equivalent...
  45. Maxwell I, Chapman J, Scherrer L, Spitzer A, Leptihn S, Maxwell F, et al. Expansion of tropism of a feline parvovirus to target a human tumor cell line by display of an alpha(v) integrin binding peptide on the capsid. Gene Ther. 2001;8:324-31 pubmed
    ..They occur in many species and they have oncolytic properties. We are modifying the capsid of feline panleukopenia virus (FPV), a parvovirus which normally infects feline cells, with the goal of targeting human tumor cells ..
  46. Garigliany M, Gilliaux G, Jolly S, Casanova T, Bayrou C, Gommeren K, et al. Feline panleukopenia virus in cerebral neurons of young and adult cats. BMC Vet Res. 2016;12:28 pubmed publisher
    Perinatal infections with feline panleukopenia virus (FPV) have long been known to be associated with cerebellar hypoplasia in kittens due to productive infection of dividing neuroblasts...
  47. Clemens D, Carlson J. Regulated expression of the feline panleukopenia virus P38 promoter on extrachromosomal FPV/EBV chimeric plasmids. J Virol. 1989;63:2737-45 pubmed
    b>Feline panleukopenia virus/Epstein-Barr virus (FPV/EBV) chimeric expression plasmids were constructed to study regulation of the structural protein gene of the parvovirus, FPV, in a homologous cell culture system...
  48. Kurtzman G, Platanias L, Lustig L, Frickhofen N, Young N. Feline parvovirus propagates in cat bone marrow cultures and inhibits hematopoietic colony formation in vitro. Blood. 1989;74:71-81 pubmed
    ..Recombinant human colony stimulating factors GM-CSF and G-CSF supported feline myelopoiesis in progenitor assays, and FPV completely inhibited factor dependent colony formation...
  49. Hofmann Lehmann R, Fehr D, Grob M, Elgizoli M, Packer C, Martenson J, et al. Prevalence of antibodies to feline parvovirus, calicivirus, herpesvirus, coronavirus, and immunodeficiency virus and of feline leukemia virus antigen and the interrelationship of these viral infections in free-ranging lions in east Africa. Clin Diagn Lab Immunol. 1996;3:554-62 pubmed
  50. Addie D, Toth S, Thompson H, Greenwood N, Jarrett J. Detection of feline parvovirus in dying pedigree kittens. Vet Rec. 1998;142:353-6 pubmed
    ..The most likely explanation for the occurrence of FPV-associated disease was exposure of the young kittens to large doses of virus contaminating the environment...
  51. Kruse B, Unterer S, Horlacher K, Sauter Louis C, Hartmann K. Prognostic factors in cats with feline panleukopenia. J Vet Intern Med. 2010;24:1271-6 pubmed publisher
    ..Feline panleukopenia is a highly contagious and often lethal disease...
  52. Scott F, Geissinger C. Long-term immunity in cats vaccinated with an inactivated trivalent vaccine. Am J Vet Res. 1999;60:652-8 pubmed
    To evaluate duration of immunity in cats vaccinated with an inactivated vaccine of feline panleukopenia virus (FPV), feline herpesvirus (FHV), and feline calicivirus (FCV).
  53. Goodman L, Lyi S, Johnson N, Cifuente J, Hafenstein S, Parrish C. Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection. J Virol. 2010;84:4969-78 pubmed publisher
    Canine parvovirus (CPV) and its relative feline panleukopenia virus (FPV) bind the transferrin receptor type 1 (TfR) to infect their host cells but show differences in the interactions with the feline and canine TfRs that determine viral ..
  54. Yu Y, Zhou M, Zhang J, Hua Y, Wang L, Liu Y, et al. [Preparation of the vaccine with inactivated Feline Panleukopenia Virus isolated from tiger and the preliminary application]. Wei Sheng Wu Xue Bao. 2009;49:643-7 pubmed
    To prepare a vaccine with inactivated Feline Panleukopenia Virus (FPV) isolated from Siberian tigers and to evaluate its immunological effect.
  55. Maxwell I, Maxwell F. Parvovirus LuIII transducing vectors packaged by LuIII versus FPV capsid proteins: the VP1 N-terminal region is not a major determinant of human cell permissiveness. J Gen Virol. 2004;85:1251-7 pubmed
    ..The experimental results did not bear out either of these predictions. Therefore, the VP1 N-terminal region appears not to be a major determinant of permissiveness for LuIII, versus FPV, capsid in human cells...
  56. Zuffa T. [The growth of attenuated strains of canine parvovirus, mink enteritis virus, feline panleukopenia virus, and rabies virus on various types of cell cultures]. Vet Med (Praha). 1987;32:633-40 pubmed
    ..In the KEB and VERO cultures the highest values of infection titres were recorded on the fourth day p. i., the course of virus multiplication on the cells being parallel with its release into the culture medium...
  57. Poncelet L, Héraud C, Springinsfeld M, Ando K, Kabova A, Beineke A, et al. Identification of feline panleukopenia virus proteins expressed in Purkinje cell nuclei of cats with cerebellar hypoplasia. Vet J. 2013;196:381-7 pubmed publisher
    ..Undefined parvoviral proteins have been detected in Purkinje cells of the cerebellum after experimental feline panleukopenia virus (FPV) infection of neonatal kittens and in naturally occurring cases of feline cerebellar hypoplasia...
  58. DiGangi B, Gray L, Levy J, Dubovi E, Tucker S. Detection of protective antibody titers against feline panleukopenia virus, feline herpesvirus-1, and feline calicivirus in shelter cats using a point-of-care ELISA. J Feline Med Surg. 2011;13:912-8 pubmed publisher
    Serum antibody titers are a useful measurement of protection against infection (feline panleukopenia virus [FPV]) or clinical disease (feline herpesvirus-1 [FHV] and feline calicivirus [FCV]), and their determination has been recommended ..
  59. Decaro N, Desario C, Lucente M, Amorisco F, Campolo M, Elia G, et al. Specific identification of feline panleukopenia virus and its rapid differentiation from canine parvoviruses using minor groove binder probes. J Virol Methods. 2008;147:67-71 pubmed
    ..Using this assay for extensive molecular surveys will provide precise information on the real circulation of the CPV antigenic variants, including the new variant 2c, in cat population worldwide...
  60. Camero M, Cavalli A, Bozzo G, Decaro N, Aliberti A, Martella V, et al. A severe dual infection by feline panleukopenia virus and feline calicivirus in an adult cat. New Microbiol. 2004;27:79-82 pubmed
    A dual infection by feline panleukopenia virus (FPV) and feline calicivirus (FCV) in a 7 month-old cat is described...
  61. McKnight C, Maes R, Wise A, Kiupel M. Evaluation of tongue as a complementary sample for the diagnosis of parvoviral infection in dogs and cats. J Vet Diagn Invest. 2007;19:409-13 pubmed
    Diagnosis of canine parvovirus type 2 and feline panleukopenia virus infection in dogs and cats may be hampered by the severity of enteric lesions, secondary bacterial overgrowth, and rapid onset of autolysis...
  62. Duarte M, Henriques A, Barros S, Fagulha T, Mendonça P, Carvalho P, et al. Snapshot of viral infections in wild carnivores reveals ubiquity of parvovirus and susceptibility of Egyptian mongoose to feline panleukopenia virus. PLoS ONE. 2013;8:e59399 pubmed publisher
    ..sequence of the vp2 gene, allowed typifying three viral strains of mongoose and four red fox's as feline panleukopenia virus (FPLV) and one stone marten's as newCPV-2b type...
  63. Hueffer K, Govindasamy L, Agbandje McKenna M, Parrish C. Combinations of two capsid regions controlling canine host range determine canine transferrin receptor binding by canine and feline parvoviruses. J Virol. 2003;77:10099-105 pubmed
    b>Feline panleukopenia virus (FPV) and its host range variant, canine parvovirus (CPV), can bind the feline transferrin receptor (TfR), while only CPV binds to the canine TfR...
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    ..5 microg of peptide. Also, KLH can be replaced as a carrier for a much cheaper alternative such as ovalbumine. All these findings implicate a substantial reduction in the cost of the vaccinal dose...
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    ..FIPV-induced p38 MAPK activation was observed in primary feline blood-derived mononuclear cells individually purified from multiple SPF cats, as was the inhibition of TNF-alpha production by pyridinyl imidazole inhibitors...
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    ..Six other vaccine site fibrosarcomas, potentially vaccine associated using the above criteria, are summarised...
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    ..All cats were negative for FeLV. Assay results failed to correlate to the presence of GS in the group of cats studied...
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    ..a programmed step electric field strength (PSEFS) method was investigated for fast parallel detection of feline panleukopenia virus (FPV) DNA...
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    ..Thus, it appears that much of the hypergammaglobulinemia in mink with Aleutian disease represents virus-specific antibody...
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    In this study we reported a case of co-infection with canine parvovirus (CPV) type 2a and feline panleukopenia virus (FPV) in a 3-month-old male kitten, with the presence of a parvovirus variant which is a true intermediate between CPV ..
  72. Rivera E, Karlsson K. A solid-phase fluorescent immunoassay for detecting canine or mink enteritis parvoviruses in faecal samples. Vet Microbiol. 1987;15:1-9 pubmed
    ..Furthermore, the use of IB as the matrix for the immunological reactions allows FITC- or enzyme-conjugated antibodies to be used as indicators of the reactions and a simultaneous investigation of several pathogenic agents...
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    ..In leopard cats, the positive rate of FPV was high (3/4) and it indicated that FPV was prevailing in leopard cats in Vietnam...
  74. Parker J, Murphy W, Wang D, O Brien S, Parrish C. Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells. J Virol. 2001;75:3896-902 pubmed
    ..S. L. Parker and C. R. Parrish, J. Virol. 74:1919-1930, 2000). Here we report that CPV and feline panleukopenia virus (FPV), a closely related parvovirus, bind to the human and feline transferrin receptors (TfRs) and use ..
  75. van Vuuren M, Steinel A, Goosen T, Lane E, van der Lugt J, Pearson J, et al. Feline panleukopenia virus revisited: molecular characteristics and pathological lesions associated with three recent isolates. J S Afr Vet Assoc. 2000;71:140-3 pubmed
    ..Phylogenetic comparison with other FPV isolates did not reveal a particular African cluster...
  76. Whittemore J, Hawley J, Jensen W, Lappin M. Antibodies against Crandell Rees feline kidney (CRFK) cell line antigens, alpha-enolase, and annexin A2 in vaccinated and CRFK hyperinoculated cats. J Vet Intern Med. 2010;24:306-13 pubmed publisher
    ..The identities of common CRFK antigens are unknown...
  77. Weiss R, Oostrom Ram T. Inhibitory effects of ribavirin alone or combined with human alpha interferon on feline infectious peritonitis virus replication in vitro. Vet Microbiol. 1989;20:255-65 pubmed
    ..Potentially, synergistic combinations of the two antiviral agents in vivo may decrease the therapeutic dose of ribavirin required for inhibition of FIPV and thus reduce drug toxicity...
  78. Wang D, Parrish C. A heterogeneous nuclear ribonucleoprotein A/B-related protein binds to single-stranded DNA near the 5' end or within the genome of feline parvovirus and can modify virus replication. J Virol. 1999;73:7761-8 pubmed
    ..clones prepared from feline cells was used to identify host cell proteins that bound to DNA-containing feline panleukopenia virus (FPV) capsids but not to empty capsids...