Summary: A family of nucleocytoplasmic, large, double-stranded DNA viruses with extremely complex genomes.
Katzourakis A, Aswad A. The origins of giant viruses, virophages and their relatives in host genomes. BMC Biol. 2014;12:51 pubmed publisher
Andrade A, Rodrigues R, Oliveira G, Andrade K, Bonjardim C, La Scola B, et al
. Filling Knowledge Gaps for Mimivirus Entry, Uncoating, and Morphogenesis. J Virol. 2017;91: pubmed publisher
..Furthermore, we demonstrate that atypical virion morphologies can occur even in the absence of virophages. Our results, along with previous data, allow us to present an ultimate model for the mimivirus replication cycle. ..
Fischer M, Condit R. Editorial introduction to "Giant Viruses" special issue of Virology. Virology. 2014;466-467:1-2 pubmed publisher
Gallot LavallÃ©e L, Blanc G, Claverie J. Comparative Genomics of Chrysochromulina Ericina Virus and Other Microalga-Infecting Large DNA Viruses Highlights Their Intricate Evolutionary Relationship with the Established Mimiviridae Family. J Virol. 2017;91: pubmed publisher
..ericina, formerly Chrysochromulina ericina), is phylogenetically related to members of the Mimiviridae family, initially established with the acanthamoeba-infecting mimivirus and megavirus as prototypes...
Raoult D, Levasseur A, La Scola B. PCR Detection of Mimivirus. Emerg Infect Dis. 2017;23:1044-1045 pubmed publisher
Colson P, La Scola B, Raoult D. Giant Viruses of Amoebae: A Journey Through Innovative Research and Paradigm Changes. Annu Rev Virol. 2017;4:61-85 pubmed publisher
..This new paradigm is propitious for enhanced detection and characterization of giant viruses of amoebae, and a particular focus on their role in humans is warranted. ..
Kwon E, Pathak D, Chang H, Kim D. Crystal structure of mimivirus uracil-DNA glycosylase. PLoS ONE. 2017;12:e0182382 pubmed publisher
..Deletion of the three additional fragments reduced the activity and thermal stability, compared to full-length mvUNG. The results suggested that the mvUNG N-domain and motif-I are required for its structural and functional integrity. ..
Ku B, You J, Oh K, Yun H, Lee H, Shin H, et al
. Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase. Arch Virol. 2017;162:3407-3416 pubmed publisher
..However, it also contains unique structural features differentiating it from mammalian homologues, such as the functional substitution of a phenylalanine residue for the stabilization of the nucleotide's guanine base. ..
Arroyo MÃ¼hr L, Bzhalava Z, Hortlund M, Lagheden C, Nordqvist Kleppe S, Bzhalava D, et al
. Viruses in cancers among the immunosuppressed. Int J Cancer. 2017;141:2498-2504 pubmed publisher
..Among the 62 NMSCs, the virus family detected in the largest proportion of specimens was Mimiviridae (9/62 NMSCs). The majority of the virus-related reads belonged to Papillomaviridae...