human herpesvirus 7

Summary

Summary: A species in the genus ROSEOLOVIRUS, of the family HERPESVIRIDAE. It was isolated from activated, CD4-positive T-lymphocytes taken from the blood of a healthy human.

Top Publications

  1. Pohl Koppe A, Blay M, Jager G, Weiss M. Human herpes virus type 7 DNA in the cerebrospinal fluid of children with central nervous system diseases. Eur J Pediatr. 2001;160:351-8 pubmed
    ..These children were diagnosed with aseptic meningitis (n = 1), viral encephalitis/meningoencephalitis (n = 2), facial palsy (n = 1), vestibular neuritis (n = 1) and febrile seizure (n = 1)...
  2. Gonelli A, Boccia S, Boni M, Pozzoli A, Rizzo C, Querzoli P, et al. Human herpesvirus 7 is latent in gastric mucosa. J Med Virol. 2001;63:277-83 pubmed
    ..The present study was undertaken to evaluate a possible etiologic role of human herpesvirus 7 (HHV-7)...
  3. Miyake F, Yoshikawa T, Sun H, Kakimi A, Ohashi M, Akimoto S, et al. Latent infection of human herpesvirus 7 in CD4(+) T lymphocytes. J Med Virol. 2006;78:112-6 pubmed
    To determine the cell populations in peripheral blood that are infected latently with human herpesvirus 7 (HHV-7), the real-time polymerase chain reaction (PCR) was used to determine the quantities of viral DNA in adherent and non-..
  4. Sugaya N, Yoshikawa T, Miura M, Ishizuka T, Kawakami C, Asano Y. Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7. Clin Infect Dis. 2002;34:461-6 pubmed
    ..In 3 of 8 patients, the presence of human herpesvirus 7 (HHV-7) DNA was demonstrated in CSF specimens...
  5. Yagami A, Yoshikawa T, Asano Y, Koie S, Shiohara T, Matsunaga K. Drug-induced hypersensitivity syndrome due to mexiletine hydrochloride associated with reactivation of human herpesvirus 7. Dermatology. 2006;213:341-4 pubmed
    ..All samples, however, were found to contain HHV-7 DNA. Reactivation of HHV-7 could be responsible for drug-induced hypersensitivity syndrome...
  6. Hall C, Caserta M, Schnabel K, Boettrich C, McDermott M, Lofthus G, et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr. 2004;145:472-7 pubmed
    To examine whether: (1) congenital human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) infections occur; whether (2) their manifestations differ from postnatal infections; and whether (3) HHV6 and HHV7 infections differ despite ..
  7. Lisco A, Grivel J, Biancotto A, Vanpouille C, Origgi F, Malnati M, et al. Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation. J Virol. 2007;81:708-17 pubmed
    ..Here, we identified another virus, human herpesvirus 7 (HHV-7) that interferes with HIV type 1 (HIV-1) replication in human lymphoid tissue, where critical events ..
  8. Secchiero P, Sun D, De Vico A, Crowley R, Reitz M, Zauli G, et al. Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans. J Virol. 1997;71:4571-80 pubmed
    In an attempt to identify the human herpesvirus 7 (HHV-7) envelope protein(s) involved in cell surface binding, the extracellular domain of the HHV-7 glycoprotein B (gB) homolog protein was cloned and expressed as a fusion product with ..
  9. Chuh A, Kempf W. The identification of primary human herpesvirus 7 infection in young adults with pityriasis rosea by investigating avidity of antibodies. J Eur Acad Dermatol Venereol. 2006;20:629-30 pubmed

More Information

Publications80

  1. de Vries H, Van Marle J, Teunissen M, Picavet D, Zorgdrager F, Bos J, et al. Lichen planus is associated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells. Br J Dermatol. 2006;154:361-4 pubmed
    ..Lichen planus (LP) is a common inflammatory skin disease of unknown aetiology. Viral causes have been suggested...
  2. Berneman Z, Torelli G, Luppi M, Jarrett R. Absence of a directly causative role for human herpesvirus 7 in human lymphoma and a review of human herpesvirus 6 in human malignancy. Ann Hematol. 1998;77:275-8 pubmed
    ..disease (HD) and 43 samples (32 lymph node and 11 skin biopsies) from non-Hodgkin's lymphoma (NHL) for human herpesvirus 7 (HHV-7). Twenty-nine control samples were tested as well, including 17 with benign lymphadenopathy...
  3. Zhang Y, Hatse S, De Clercq E, Schols D. CXC-chemokine receptor 4 is not a coreceptor for human herpesvirus 7 entry into CD4(+) T cells. J Virol. 2000;74:2011-6 pubmed
    b>Human herpesvirus 7 (HHV-7) is a T-lymphotropic virus which utilizes the CD4 receptor as its main receptor to enter the target cells. Hence, HHV-7 can interfere with human immunodeficiency virus type 1 (HIV-1) infection in CD4(+) T cells...
  4. May N, Glosson N, Hudson A. Human herpesvirus 7 u21 downregulates classical and nonclassical class I major histocompatibility complex molecules from the cell surface. J Virol. 2010;84:3738-51 pubmed publisher
    ..Here, we show that human herpesvirus 7 (HHV-7) U21 binds to and downregulates all of the human class I MHC gene products, as well as the murine ..
  5. Krueger G, Koch B, Leyssens N, Berneman Z, Rojo J, Horwitz C, et al. Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries. Vox Sang. 1998;75:193-7 pubmed
    ..The purpose of the study was to register antibody prevalences of HHV-7 in various locations of the world in comparison to the closely related HHV-6...
  6. Yoshikawa T, Ihira M, Suzuki K, Suga S, Matsubara T, Furukawa S, et al. Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms. Arch Dis Child. 2000;83:170-1 pubmed
    ..Human herpesvirus 6 (HHV-6) and HHV-7 DNA was detected in cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) by nested polymerase chain reaction...
  7. Nagore E, Ledesma E, Collado C, Oliver V, Perez Perez A, Aliaga A. Detection of Epstein-Barr virus and human herpesvirus 7 and 8 genomes in primary cutaneous T- and B-cell lymphomas. Br J Dermatol. 2000;143:320-3 pubmed
    ..Several studies have investigated the possible involvement of viral agents, particularly herpesviruses, in primary cutaneous lymphoma (PCL)...
  8. Ponti R, Bergallo M, Costa C, Quaglino P, Fierro M, Comessatti A, et al. Human herpesvirus 7 detection by quantitative real time polymerase chain reaction in primary cutaneous T-cell lymphomas and healthy subjects: lack of a pathogenic role. Br J Dermatol. 2008;159:1131-7 pubmed publisher
  9. Gonelli A, Mirandola P, Grill V, Secchiero P, Zauli G. Human herpesvirus 7 infection impairs the survival/differentiation of megakaryocytic cells. Haematologica. 2002;87:1223-5 pubmed
    ..These data suggest that HHV-7 reactivation in the bone marrow of HIV-1 infected individuals may contribute to impair megakaryocytopoiesis...
  10. Hara H, Kobayashi M, Yokoyama A, Tochigi M, Matsunaga A, Shimizu H, et al. Drug-induced hypersensitivity syndrome due to carbamazepine associated with reactivation of human herpesvirus 7. Dermatology. 2005;211:159-61 pubmed
    ..Titers of human herpesvirus 7 (HHV-7)-specific IgG antibodies were significantly increased and HHV-7 DNA was detected in his serum by ..
  11. Drago F, Vecchio F, Rebora A. Use of high-dose acyclovir in pityriasis rosea. J Am Acad Dermatol. 2006;54:82-5 pubmed
    ..The association of human herpesvirus 6 (HHV-6) and HHV-7 with pityriasis rosea suggests that systemic drugs directed against HHV may hasten recovery of patients with pityriasis rosea...
  12. Tomsone V, Logina I, Millers A, Chapenko S, Kozireva S, Murovska M. Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system. J Neurovirol. 2001;7:564-9 pubmed
    ..A significantly higher frequency of HHV-7 reactivation in patients with demyelinating diseases of the peripheral nervous system suggests also its association with demyelinating processes...
  13. Chan P, Li C, Chik K, Lee V, Shing M, Ng K, et al. Risk factors and clinical consequences of human herpesvirus 7 infection in paediatric haematopoietic stem cell transplant recipients. J Med Virol. 2004;72:668-74 pubmed
    b>Human herpesvirus 7 (HHV-7) is the least studied beta-herpesvirus in transplant settings. This prospective study examined the activity of HHV-7 during the first 12 weeks post-stem cell transplant in 59 paediatric patients...
  14. Latchney L, Fallon M, Culp D, Gelbard H, Dewhurst S. Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands. J Histochem Cytochem. 2004;52:671-81 pubmed
    ..In contrast, HHV-7-infected epithelial cells did not always express fractalkine, suggesting that fractalkine may not be an absolute requirement for viral entry...
  15. Vag T, Sonkoly E, Karpati S, Kemeny B, Ongradi J. Avidity of antibodies to human herpesvirus 7 suggests primary infection in young adults with pityriasis rosea. J Eur Acad Dermatol Venereol. 2004;18:738-40 pubmed
  16. Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, et al. Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7. Microbiol Immunol. 2009;53:22-9 pubmed publisher
    ..The detection rate for each viral DNA was 6.7% for HSV, 9.5% for HHV-6, and 1.9% for HHV-7. These results indicate that our system is reliable and may be useful for the rapid diagnosis of viral encephalitis/encephalopathy...
  17. Emery V. Human herpesviruses 6 and 7 in solid organ transplant recipients. Clin Infect Dis. 2001;32:1357-60 pubmed
    ..Also discussed is whether the data on the pathological consequences of infection warrant routine screening for these viruses in solid organ transplant recipients...
  18. Lanphear B, Hall C, Black J, Auinger P. Risk factors for the early acquisition of human herpesvirus 6 and human herpesvirus 7 infections in children. Pediatr Infect Dis J. 1998;17:792-5 pubmed
    ..Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are common infections in children, but risk factors for their early acquisition have not been described...
  19. Broccolo F, Iuliano R, Careddu A, Trovato R, Lico S, Blanc P, et al. Detection of lymphotropic herpesvirus DNA by polymerase chain reaction in cerebrospinal fluid of AIDS patients with neurological disease. Acta Virol. 2000;44:137-43 pubmed
    ..found in 26 of 49 patients (53%): CMV in 16 (33%), EBV in 13 (27%), human herpesvirus 6 (HHV-6) in 2 (4%), human herpesvirus 7 (HHV-7) in 1 (2%), and human herpesvirus 8 (HHV-8) in 1 (2%)...
  20. Yoshida M, Yamada M, Tsukazaki T, Chatterjee S, Lakeman F, Nii S, et al. Comparison of antiviral compounds against human herpesvirus 6 and 7. Antiviral Res. 1998;40:73-84 pubmed
    ..were evaluated for inhibitory activity against two variants of human herpesvirus 6 (HHV-6A and -6B) and human herpesvirus 7 (HHV-7)...
  21. Kidd I, Clark D, Sabin C, Andrew D, Hassan Walker A, Sweny P, et al. Prospective study of human betaherpesviruses after renal transplantation: association of human herpesvirus 7 and cytomegalovirus co-infection with cytomegalovirus disease and increased rejection. Transplantation. 2000;69:2400-4 pubmed
    ..We have conducted a prospective investigation to compare the natural history of HHV-6 and HHV-7 infection with that of CMV after renal transplantation...
  22. Secchiero P, Mirandola P, Zella D, Celeghini C, Gonelli A, Vitale M, et al. Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4(+) T cells. Blood. 2001;98:2474-81 pubmed
    b>Human herpesvirus 7 (HHV-7) is endemic in the adult human population. Although HHV-7 preferentially infects activated CD4(+) T lymphocytes, the consequence of T-cell infection for viral pathogenesis and immunity are still largely unknown...
  23. Tong C, Bakran A, Williams H, Cheung C, Peiris J. Association of human herpesvirus 7 with cytomegalovirus disease in renal transplant recipients. Transplantation. 2000;70:213-6 pubmed
    ..Recent studies have linked human herpesviruses 6 (HHV-6) and 7 (HHV-7) with posttransplant cytomegalovirus (CMV) disease...
  24. Black J, Burns D, Goldsmith C, Feorino P, Kite Powell K, Schinazi R, et al. Biologic properties of human herpesvirus 7 strain SB. Virus Res. 1997;52:25-41 pubmed
    The growth characteristics of human herpesvirus 7 strain SB (HHV-7 (SB)) were studied in human umbilical cord blood lymphocyte (CBL) cultures...
  25. Secchiero P, Zella D, Barabitskaja O, Reitz M, Capitani S, Gallo R, et al. Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7. Blood. 1998;92:4521-8 pubmed
    We have previously shown that infection of CD4(+) T lymphocytes with the T-lymphotropic human herpesvirus 7 (HHV-7) downregulates surface CD4, which represents the high-affinity receptor for HHV-7...
  26. Tadagaki K, Nakano K, Yamanishi K. Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors. J Virol. 2005;79:7068-76 pubmed
    b>Human herpesvirus 7 (HHV-7), which belongs to the betaherpesvirus subfamily and infects mainly CD4+ T cells in vitro, infects children during infancy...
  27. Black J, Pellett P. Human herpesvirus 7. Rev Med Virol. 1999;9:245-62 pubmed
    b>Human herpesvirus 7, reported in 1990 is a lymphotropic member of the betaherpesvirus subfamily of herpesviruses...
  28. Caselli E, Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiol. 2007;30:173-87 pubmed
    Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are members of the Roseolovirus genus within the Betaherpesvirinae subfamily...
  29. Rotola A, Cassai E, Farina R, Caselli E, Gentili V, Lazzarotto T, et al. Human herpesvirus 7, Epstein-Barr virus and human cytomegalovirus in periodontal tissues of periodontally diseased and healthy subjects. J Clin Periodontol. 2008;35:831-7 pubmed publisher
    To evaluate (i) the presence of human herpesvirus 7 (HHV-7), Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV), and (ii) the transcription pattern of HHV-7 in gingival biopsies from patients affected by periodontitis (P) and ..
  30. Hudson A, Howley P, Ploegh H. A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes. J Virol. 2001;75:12347-58 pubmed
    ..In doing so, herpesviruses exploit a surprising number of different strategies to evade the immune system. Human herpesvirus 7 (HHV-7) is a relatively recently discovered member of the herpesvirus family, and little is known about how ..
  31. Vermeire K, Zhang Y, Princen K, Hatse S, Samala M, Dey K, et al. CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor. Virology. 2002;302:342-53 pubmed
    ..3-3.2 microM) and human herpesvirus 7 (HHV-7) infection (IC50, 0.3-1.5 microM) in T-cell lines and PBMCs...
  32. Thomasini R, Sampaio A, Bonon S, Boin I, Leonardi L, Leonardi M, et al. Detection and monitoring of human herpesvirus 7 in adult liver transplant patients: impact on clinical course and association with cytomegalovirus. Transplant Proc. 2007;39:1537-9 pubmed
    ..Further studies should be performed including HHV-6 to evaluate the relationship, among beta herpesviruses...
  33. Canpolat Kirac B, Adisen E, Bozdayi G, Yucel A, Fidan I, Aksakal N, et al. The role of human herpesvirus 6, human herpesvirus 7, Epstein-Barr virus and cytomegalovirus in the aetiology of pityriasis rosea. J Eur Acad Dermatol Venereol. 2009;23:16-21 pubmed publisher
    ..To identify the role of human herpesvirus 6 (HHV-6), HHV-7, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in the pathogenesis of pityriasis rosea (PR)...
  34. Drago F, Malaguti F, Ranieri E, Losi E, Rebora A. Human herpes virus-like particles in pityriasis rosea lesions: an electron microscopy study. J Cutan Pathol. 2002;29:359-61 pubmed
    ..Our results confirm our previous findings and provides further evidence of a viral etiology for pityriasis rosea. ..
  35. Boutolleau D, Bonduelle O, Agut H, Gautheret Dejean A. Is human herpesvirus-7 a marker or a competitor for HIV progression?. AIDS. 2004;18:358-9 pubmed
  36. Tsutsui Y. [Beta-herpesvirus infection of the central nervous system]. Nihon Rinsho. 2006;64 Suppl 3:440-5 pubmed
  37. Wang L, Dong L, Lu D. [Human herpesvirus 7 infection in patients after allogeneic hematopoietic stem cell transplantation]. Zhonghua Yi Xue Za Zhi. 2007;87:2113-6 pubmed
    To study the prevalence of human herpesvirus 7 (HHV-7) infection in recipients following allogeneic hematopoietic stem cell transplantation (allo-HSCT)...
  38. Vivoli R, Rovesti S, Borella P, Cermelli C. Relation between psychoneuroendocrine profile in stressful conditions and antibodies to herpesvirus 6 and 7. J Biol Regul Homeost Agents. 2008;22:239-45 pubmed
  39. Kondo K. [Application of human herpesvirus (HHV)-6 and HHV-7 to the gene therapy vectors]. Nihon Rinsho. 2006;64 Suppl 3:518-22 pubmed
  40. Chuh A, Chan H, Zawar V. Is human herpesvirus 7 the causative agent of pityriasis rosea?--A critical review. Int J Dermatol. 2004;43:870-5 pubmed
    Conflicting results on the association of pityriasis rosea and human herpesvirus 7 infection have been reported by different investigators. To review the level of evidence for such an association...
  41. Manuel O, Kumar D, Moussa G, Chen M, Pilewski J, McCurry K, et al. Lack of association between beta-herpesvirus infection and bronchiolitis obliterans syndrome in lung transplant recipients in the era of antiviral prophylaxis. Transplantation. 2009;87:719-25 pubmed publisher
    ..However, despite high viral loads in many patients, virus replication was not associated with the development of rejection or BOS. ..
  42. Costa Silva M, Calistru A, Sobrinho Simões J, Lisboa C, Azevedo F. Pitiryasis Lichenoides et Varioliformis Aacuta Associated With Human Herpesvirus 7. Actas Dermosifiliogr. 2018;109:e6-e10 pubmed publisher
    ..Herein we describe 2 cases of pityriasis lichenoides et varioliformis acuta, in which human herpesvirus 7 DNA was detected in skin samples by polymerase chain reaction methodology, an association not previously ..
  43. Astegiano S, Costa C, Terlizzi M, Sidoti F, Gambarino S, Mantovani S, et al. Detection of human herpesvirus-7 DNA in bronchoalveolar lavage. Intervirology. 2010;53:119-23 pubmed publisher
    ..The evaluation of HHV-7 DNA in BAL may be useful to investigate its potential role in lower respiratory tract infection, alone or in association with other viral and/or non-viral pathogens and to distinguish latency from reactivation. ..
  44. Ashshi A, Klapper P, Cooper R. Detection of human cytomegalovirus, human herpesvirus type 6 and human herpesvirus type 7 in urine specimens by multiplex PCR. J Infect. 2003;47:59-64 pubmed
    ..Urine may be a useful non-invasive specimen for the detection of HHV6 and HHV7 and their presence in neonates suggest perinatal transmission or the possibility of in utero infection. ..
  45. Kumar D. Emerging viruses in transplantation. Curr Opin Infect Dis. 2010;23:374-8 pubmed publisher
    ..Antiviral options for these viruses are limited, and decreasing immunosuppression is the cornerstone of therapy. ..
  46. Corral I, Sainz de la Maza S, Rodriguez M, Kawiorski M, Lopez Martinez M, Galan J. Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders. J Neurovirol. 2018;24:333-338 pubmed publisher
    ..Foscarnet seems the first-line treatment for HHV-7 CNS disease. ..
  47. Yoshikawa T, Ihira M, Taguchi H, Yoshida S, Asano Y. Analysis of shedding of 3 beta-herpesviruses in saliva from patients with connective tissue diseases. J Infect Dis. 2005;192:1530-6 pubmed
    ..These data suggest that a number of host factors in patients with adult-onset Still disease may function to accelerate HHV-7 replication in the salivary glands. ..
  48. Campadelli Fiume G, Mirandola P, Menotti L. Human herpesvirus 6: An emerging pathogen. Emerg Infect Dis. 1999;5:353-66 pubmed
    ..Another disease whose pathogenesis may be correlated with HHV-6 is multiple sclerosis. Data in favor of and against the correlation are discussed...
  49. Mendez J, Dockrell D, Espy M, Smith T, Wilson J, Harmsen W, et al. Human beta-herpesvirus interactions in solid organ transplant recipients. J Infect Dis. 2001;183:179-184 pubmed
    ..These results suggest that CMV disease in transplant recipients is related to the unique interaction of the 3 beta-herpesviruses and is ultimately reduced after intravenous Gcv treatment. ..
  50. Pascher A, Klupp J, Schulz R, Dignass A, Neuhaus P. CMV, EBV, HHV6, and HHV7 infections after intestinal transplantation without specific antiviral prophylaxis. Transplant Proc. 2004;36:381-2 pubmed
    ..Donor-recipient matching regarding CMV was not predictive for the occurrence of CMV-related complications. HHV6 and HHV7 have not contributed to posttransplant morbidity. ..
  51. Kano Y, Inaoka M, Sakuma K, Shiohara T. Virus reactivation and intravenous immunoglobulin (IVIG) therapy of drug-induced hypersensitivity syndrome. Toxicology. 2005;209:165-7 pubmed
    ..In addition, recent articles have shown that reactivation of other herpesviruses such as human herpesvirus 7 (HHV-7), Epstein-Barr virus (EBV), cytomegalovirus (CMV) might be also implicated in the development of ..
  52. Caserta M, McDermott M, Dewhurst S, Schnabel K, Carnahan J, Gilbert L, et al. Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children. J Pediatr. 2004;145:478-84 pubmed
    ..primary infection the persistence of human herpesvirus 6 (HHV6) DNA, the presence and frequency of HHV6 re-activation or re-infection, and the relationship of both to illness and the presence of human herpesvirus 7 (HHV7) infection.
  53. Ono J, Imai K, Tanaka Taya K, Kurahashi H, Okada S. Decreased frequency of seizures in infantile spasms associated with lissencephaly by human herpes virus 7 infection. Pediatr Int. 2002;44:168-70 pubmed
  54. Suga S. [Exanthem subitum]. Nihon Rinsho. 2006;64 Suppl 3:472-5 pubmed
  55. Bergstrom T. [HHV 6,7 and 8. Recently discovered herpesviruses explain the etiology of well-known diseases]. Lakartidningen. 1999;96:3161-5 pubmed
    ..Recent research has been focused on the involvement of proteins expressed by HHV-8 in the pathogenesis of two rare tumours, Kaposi's sarcoma and body-cavity B-cell lymphomas...
  56. Ihira M, Yoshikawa T, Suzuki K, Ohashi M, Suga S, Asonuma K, et al. Correlation between human herpesvirus 6 and 7 infections after living related liver transplantation. Microbiol Immunol. 2001;45:225-32 pubmed
    Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are closely related to each other. Interaction between the two viruses at the time of primary HHV-7 infection is suggested by in vivo and in vitro studies...
  57. Kawada J, Kimura H, Hara S, Ito Y, Kawashima H, Okuno T, et al. Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7. Pediatr Infect Dis J. 2003;22:115-9 pubmed
    ..complications of influenza, including encephalopathy, are associated with human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7)...
  58. Persson L, Dahl H, Linde A, Engervall P, Vikerfors T, Tidefelt U. Human cytomegalovirus, human herpesvirus-6 and human herpesvirus-7 in neutropenic patients with fever of unknown origin. Clin Microbiol Infect. 2003;9:640-4 pubmed
    ..To investigate the appearance of cytomegalovirus (CMV) DNA, human herpesvirus-6 (HHV-6) DNA and human herpesvirus-7 (HHV-7) DNA in plasma as a sign of reactivation and possible causes of fever of unknown origin (FUO) during neutropenia...
  59. Katzoli P, Sakellaris G, Ergazaki M, Charissis G, Spandidos D, Sourvinos G. Detection of herpes viruses in children with acute appendicitis. J Clin Virol. 2009;44:282-6 pubmed publisher
  60. Safronetz D, Humar A, Tipples G. Differentiation and quantitation of human herpesviruses 6A, 6B and 7 by real-time PCR. J Virol Methods. 2003;112:99-105 pubmed
    ..The lower limit of detection for all three viruses was determined to be ten viral genomes. This real-time PCR assay will be useful for differentiation and quantitation of HHV-6A, -6B and -7, especially for monitoring transplant patients...
  61. Gupta M, Diaz Mitoma F, Feber J, Shaw L, Forget C, Filler G. Tissue HHV6 and 7 determination in pediatric solid organ recipients--a pilot study. Pediatr Transplant. 2003;7:458-63 pubmed
    ..This may explain the high prevalence of HHV6 in transplanted kidneys. Further studies on HHV6 and 7 using molecular techniques should be supported...
  62. Nakano K, Tadagaki K, Isegawa Y, Aye M, Zou P, Yamanishi K. Human herpesvirus 7 open reading frame U12 encodes a functional beta-chemokine receptor. J Virol. 2003;77:8108-15 pubmed
    b>Human herpesvirus 7 (HHV-7), which belongs to the betaherpesvirus subfamily, infects mainly CD4+ T cells in vitro and infects children during infancy. After the primary infection, HHV-7 becomes latent...
  63. Takemoto M, Yamanishi K, Mori Y. Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells. J Gen Virol. 2007;88:1415-22 pubmed
    ..DNA microarray analysis suggested that the expression of CD46 was upregulated in T cells infected with human herpesvirus 7 (HHV-7)...
  64. Humar A. Reactivation of viruses in solid organ transplant patients receiving cytomegalovirus prophylaxis. Transplantation. 2006;82:S9-S14 pubmed
    ..CMV prophylaxis may have modified the natural history of some of these non-CMV viral infections...
  65. Bergstrom T. [Recently discovered herpes viruses explain the etiology of well-known diseases]. Tidsskr Nor Laegeforen. 1999;119:4463-6 pubmed
    ..Recent research has been focused on the involvement of proteins expressed by HHV-8 in the pathogenesis of two rare tumours, Kaposi's sarcoma and body-cavity B-cell lymphomas...
  66. Brennan D, Storch G, Singer G, Lee L, Rueda J, Schnitzler M. The prevalence of human herpesvirus-7 in renal transplant recipients is unaffected by oral or intravenous ganciclovir. J Infect Dis. 2000;181:1557-61 pubmed
    ..These results indicate that HHV-7 is resistant to ganciclovir at levels that were effective for prevention and treatment of CMV...
  67. Yao K, Dou J, Xu J, Sun H, Peng G, Ren Q, et al. Isolation of Nanjing local strains of HHV-7 and their biological and immunological characteristics. Cell Mol Immunol. 2004;1:367-72 pubmed
    ..Infection with HHV-7 in vitro could affect immune function of lymphocytes by disturbing cytokine production and CD antigen expression...
  68. Kempf W, Muller B, Maurer R, Adams V, Campadelli Fiume G. Increased expression of human herpesvirus 7 in lymphoid organs of AIDS patients. J Clin Virol. 2000;16:193-201 pubmed
    b>Human herpesvirus 7 (HHV-7) interferes reciprocally with the human immunodeficiency virus (HIV) in CD4 T lymphocytes, as infection with HIV results in a down modulation of the CD4 molecule and inhibition of replication of HHV-7, and vice ..
  69. Benito N, Moreno A, Pumarola T, Marcos M. [Human herpesvirus type 6 and type 7 in transplant recipients]. Enferm Infecc Microbiol Clin. 2003;21:424-32 pubmed
  70. Fujita A, Yoshikawa T. [HHV-6 and HHV-7 infections in transplantation]. Nihon Rinsho. 2006;64 Suppl 3:485-9 pubmed
  71. Savolainen H, Lautenschlager I, Piiparinen H, Saarinen Pihkala U, Hovi L, Vettenranta K. Human herpesvirus-6 and -7 in pediatric stem cell transplantation. Pediatr Blood Cancer. 2005;45:820-5 pubmed
    ..The presence of HHV-6 and -7 and their possible association with clinical problems among pediatric recipients of stem cell grafts was studied in a single institution setting between November 1999 and December 2001...