human herpesvirus 6

Summary

Summary: Members of the ROSEOLOVIRUS genus of the Betaherpesvirales subfamily isolated from patients with AIDS and other LYMPHOPROLIFERATIVE DISORDERS. It infects and replicates in fresh and established lines of hematopoietic cells and cells of neural origin. It also appears to alter the activity of NK CELLS. HHV-6; (HBLV) antibodies are elevated in patients with AIDS; SJOGREN'S SYNDROME; SARCOIDOSIS; CHRONIC FATIGUE SYNDROME, and certain malignancies. HHV-6A is the most common cause of EXANTHEMA SUBITUM and has been implicated in encephalitis. When HHV-6 integrates into the host genome it is referred to as ciHVH-6. When such VIRUS INTEGRATION occurs into the germline it is referred to as iciHHV-6.

Top Publications

  1. Abdel Massih R, Razonable R. Human herpesvirus 6 infections after liver transplantation. World J Gastroenterol. 2009;15:2561-9 pubmed
    b>Human herpesvirus 6 (HHV-6) infections occur in > 95% of humans...
  2. Boutolleau D, Duros C, Bonnafous P, Caïola D, Karras A, Castro N, et al. Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol. 2006;35:257-63 pubmed
    b>Human herpesvirus 6 (HHV-6) isolates are classified into two variants, termed HHV-6A and HHV-6B, on the basis of distinct genetic, antigenic and biological characteristics, but the specific pathogenicity of each variant remains poorly ..
  3. Ahlqvist J, Donati D, Martinelli E, Akhyani N, Hou J, Major E, et al. Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells. J Med Virol. 2006;78:1542-53 pubmed
    ..The HHV-6 variants behave differently in the same type of cells and have different tropisms for astrocytes, supporting the notion that the variants might induce different diseases. ..
  4. Gentile I, Talamo M, Borgia G. Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review. BMC Infect Dis. 2010;10:49 pubmed publisher
    ..b>Human herpesvirus 6 (HHV-6) DNA was positive as shown by PCR. Drug-Induced Hypersensitivity Syndrome (DIHS) was diagnosed...
  5. Zerr D. Human herpesvirus 6: a clinical update. Herpes. 2006;13:20-4 pubmed
    b>Human herpesvirus 6 (HHV-6) is a member of the Roseolovirus genus of the b-herpesvirus subfamily of human herpesviruses...
  6. Vianna R, de Oliveira S, Camacho L, Knowles W, Brown D, Pereira A, et al. Role of human herpesvirus 6 infection in young Brazilian children with rash illnesses. Pediatr Infect Dis J. 2008;27:533-7 pubmed publisher
    ..Our study confirms the importance of HHV-6 infection in young children and highlights the difficulties of diagnosing a rash illness on clinical grounds alone. ..
  7. Bates M, Monze M, Bima H, Kapambwe M, Clark D, Kasolo F, et al. Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of Sub-Saharan Africa. J Med Virol. 2009;81:779-89 pubmed publisher
    b>Human herpesvirus 6, HHV-6, commonly infects children, causing febrile illness and can cause more severe pathology, especially in an immune compromised setting...
  8. Mori Y, Koike M, Moriishi E, Kawabata A, Tang H, Oyaizu H, et al. Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway. Traffic. 2008;9:1728-42 pubmed publisher
    ..or post-Golgi compartments, such as the trans Golgi network (TGN); however, the final envelopment site of human herpesvirus 6 (HHV-6) is uncertain...
  9. Watanabe H, Daibata M, Tohyama M, Batchelor J, Hashimoto K, Iijima M. Chromosomal integration of human herpesvirus 6 DNA in anticonvulsant hypersensitivity syndrome. Br J Dermatol. 2008;158:640-2 pubmed

More Information

Publications84

  1. Clark D, Ward K. Importance of chromosomally integrated HHV-6A and -6B in the diagnosis of active HHV-6 infection. Herpes. 2008;15:28-32 pubmed
    ..Increasingly, the polymerase chain reaction (to detect viral nucleic acid) is used for diagnosis; therefore, it is important to exclude HHV-6 chromosomal integration before concluding that there is evidence of active HHV-6 infection...
  2. Galvan M, Rotola A, Govoni V, Granieri E, Cassai E, Di Luca D. Simultaneous Guillain-Barrè syndrome and active human herpesvirus 6 infection in the central nervous system. J Clin Virol. 2007;38:271-2 pubmed
  3. Holden S, Vas A. Severe encephalitis in a haematopoietic stem cell transplant recipient caused by reactivation of human herpesvirus 6 and 7. J Clin Virol. 2007;40:245-7 pubmed
  4. Voumvourakis K, Kitsos D, Tsiodras S, Petrikkos G, Stamboulis E. Human herpesvirus 6 infection as a trigger of multiple sclerosis. Mayo Clin Proc. 2010;85:1023-30 pubmed publisher
    ..reviewed the existing evidence to determine whether a relationship exists between infection with human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) and, if so, to define the strength of that relationship...
  5. Seishima M, Yamanaka S, Fujisawa T, Tohyama M, Hashimoto K. Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome. Br J Dermatol. 2006;155:344-9 pubmed
    ..The present study suggests that in addition to HHV-6 reactivation, reactivation of HHV-7, CMV and/or EBV may also occur following drug eruption in some patients with DIHS. ..
  6. Zerr D. Human herpesvirus 6 and central nervous system disease in hematopoietic cell transplantation. J Clin Virol. 2006;37 Suppl 1:S52-6 pubmed
    b>Human herpesvirus 6 infects virtually all children within the first few years of life and like other herpesviruses, establishes latency after primary infection...
  7. Yoshikawa T, Fujita A, Yagami A, Suzuki K, Matsunaga K, Ihira M, et al. Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome. J Clin Virol. 2006;37 Suppl 1:S92-6 pubmed
    b>Human herpesvirus 6 (HHV-6) reactivation has been suggested to modify the clinical features of drug induced hypersensitivity syndrome (DIHS)...
  8. Takemoto M, Imasawa T, Yamanishi K, Mori Y. Role of dendritic cells infected with human herpesvirus 6 in virus transmission to CD4(+) T cells. Virology. 2009;385:294-302 pubmed publisher
    b>Human herpesvirus 6 (HHV-6) is a ubiquitous betaherpesvirus that predominantly infects and replicates in CD4(+) T lymphocytes. However, the mechanism of HHV-6 transmission to T cells from the peripheral mucosa is unknown...
  9. Wada K, Kubota N, Ito Y, Yagasaki H, Kato K, Yoshikawa T, et al. Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay. J Clin Microbiol. 2007;45:1426-32 pubmed
    ..5-labeled probes to simultaneously quantify Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6) DNA...
  10. Achour A, Boutolleau D, Slim A, Agut H, Gautheret Dejean A. Human herpesvirus-6 (HHV-6) DNA in plasma reflects the presence of infected blood cells rather than circulating viral particles. J Clin Virol. 2007;38:280-5 pubmed
    ..HHV-6 DNA in plasma does not necessarily reflect the amount of virus produced by the active infection of distant lymphoid tissue and organs. ..
  11. Isegawa Y, Miyamoto Y, Yasuda Y, Semi K, Tsujimura K, Fukunaga R, et al. Characterization of the human herpesvirus 6 U69 gene product and identification of its nuclear localization signal. J Virol. 2008;82:710-8 pubmed publisher
    To elucidate the function of the U69 protein kinase of human herpesvirus 6 (HHV-6) in vivo, we first analyzed its subcellular localization in HHV-6-infected Molt 3 cells by using polyclonal antibodies against the U69 protein...
  12. Tavakoli N, Nattanmai S, Hull R, Fusco H, Dzigua L, Wang H, et al. Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis. J Clin Microbiol. 2007;45:3972-8 pubmed
    b>Human herpesvirus 6 (HHV-6) was detected in specimens from patients hospitalized with symptoms of encephalitis or meningitis...
  13. Vu T, Carrum G, Hutton G, Heslop H, Brenner M, Kamble R. Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;39:705-9 pubmed
    ..Given this high incidence of HHV-6 and the possibility of successful outcome with prompt treatment, a high index of suspicion of this disorder is required in recipients of monoclonal antibody supported allografts...
  14. Vinnard C, Barton T, Jerud E, Blumberg E. A report of human herpesvirus 6-associated encephalitis in a solid organ transplant recipient and a review of previously published cases. Liver Transpl. 2009;15:1242-6 pubmed publisher
    b>Human herpesvirus 6 (HHV-6) is a common pathogen among children, classically presenting as fever and rash that resolve without specific therapy (exanthem subitum or roseola infantum)...
  15. Csoma E, Deli T, Konya J, Csernoch L, Beck Z, Gergely L. Human herpesvirus 6A decreases the susceptibility of macrophages to R5 variants of human immunodeficiency virus 1: possible role of RANTES and IL-8. Virus Res. 2006;121:161-8 pubmed
    b>Human herpesvirus 6 (HHV-6) frequently reactivates in human immunodeficiency virus 1 (HIV-1) infected patients, and is thought to be a cofactor in AIDS progression...
  16. Ahram M, El Omar A, Baho Y, Lubad M. Association between human herpesvirus 6 and occurrence of multiple sclerosis among Jordanian patients. Acta Neurol Scand. 2009;120:430-5 pubmed publisher
    ..Among the infectious agents linked to MS is human herpesvirus 6 (HHV-6)...
  17. Kawabe S, Ito Y, Ohta R, Sofue A, Gotoh K, Morishima T, et al. Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy. J Med Virol. 2010;82:1410-5 pubmed publisher
    ..038). The distribution of these cytokines differed between CSF and serum. The high CSF concentration of IL-8 could play an important role in the pathogenesis of encephalopathy...
  18. Ihira M, Sugiyama H, Enomoto Y, Higashimoto Y, Sugata K, Asano Y, et al. Direct detection of human herpesvirus 6 DNA in serum by variant specific loop-mediated isothermal amplification in hematopoietic stem cell transplant recipients. J Virol Methods. 2010;167:103-6 pubmed publisher
    ..Initial validation analysis confirmed high specificity and sensitivity of the method. This method was shown to be highly reliable for monitoring active HHV-6 infection in hematopoietic stem cell transplant recipients...
  19. Hall C, Caserta M, Schnabel K, Shelley L, Carnahan J, Marino A, et al. Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. J Infect Dis. 2010;201:505-7 pubmed publisher
    Congenital human herpesvirus 6 (HHV-6) infection results from germline passage of chromosomally integrated HHV-6 (CI-HHV-6) and from transplacental passage of maternal HHV-6 infection...
  20. Zhen Z, Bradel Tretheway B, Sumagin S, Bidlack J, Dewhurst S. The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro. J Virol. 2005;79:11914-24 pubmed publisher
    b>Human herpesvirus 6 (HHV-6) is a ubiquitous T-lymphotropic betaherpesvirus that encodes two G protein-coupled receptor homologs, U12 and U51...
  21. Lamoth F, Jayet P, Aubert J, Rotman S, Mottet C, Sahli R, et al. Case report: human herpesvirus 6 reactivation associated with colitis in a lung transplant recipient. J Med Virol. 2008;80:1804-7 pubmed publisher
    Whereas human herpesvirus 6 (HHV-6) reactivation is frequent in solid organ transplant recipients, symptomatic disease is rare. A case of colitis associated with HHV-6B reactivation was observed in a lung transplant recipient...
  22. Caserta M, Hall C, Schnabel K, Lofthus G, Marino A, Shelley L, et al. Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). J Clin Virol. 2010;48:55-7 pubmed publisher
    b>Human herpesvirus 6 (HHV-6) causes ubiquitous infection in early childhood with lifelong latency or persistence. Reactivation of HHV-6 has been associated with multiple diseases including encephalitis...
  23. Leong H, Tuke P, Tedder R, Khanom A, Eglin R, Atkinson C, et al. The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. J Med Virol. 2007;79:45-51 pubmed
    A lesser-recognized form of human herpesvirus 6 (HHV-6) persistence is integration of the viral genome in a host chromosome and high viral copy numbers in blood or sera are characteristic of this phenomenon...
  24. Jaworska J, Gravel A, Flamand L. Divergent susceptibilities of human herpesvirus 6 variants to type I interferons. Proc Natl Acad Sci U S A. 2010;107:8369-74 pubmed publisher
    Two distinct human herpesvirus 6 (HHV-6) variants infect humans. HHV-6B is the etiologic agent of roseola and is associated with life-threatening neurological diseases, such as encephalitis, as well as organ transplant failure...
  25. Pohl D, Rostasy K, Krone B, Hanefeld F. Baló's concentric sclerosis associated with primary human herpesvirus 6 infection. J Neurol Neurosurg Psychiatry. 2005;76:1723-5 pubmed
    ..b>Human herpesvirus 6 (HHV-6) is a highly neurotropic virus causing severe central nervous system (CNS) infections predominantly ..
  26. Neurohr C, Huppmann P, Leuchte H, Schwaiblmair M, Bittmann I, Jaeger G, et al. Human herpesvirus 6 in bronchalveolar lavage fluid after lung transplantation: a risk factor for bronchiolitis obliterans syndrome?. Am J Transplant. 2005;5:2982-91 pubmed
    ..Identification of HHV-6 DNA in BAL fluid is a potential risk factor for BOS. Our results warrant further studies to elucidate a possible causal link between HHV-6 and BOS...
  27. Shiohara T, Kano Y. A complex interaction between drug allergy and viral infection. Clin Rev Allergy Immunol. 2007;33:124-33 pubmed
    ..We have recently provided evidence to indicate an intimate relationship between reactivation of human herpesvirus 6 (HHV-6) and the development of a severe systemic hypersensitivity reaction referred to as drug-induced ..
  28. Hall C, Caserta M, Schnabel K, Shelley L, Marino A, Carnahan J, et al. Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics. 2008;122:513-20 pubmed publisher
    We examined the frequency and characteristics of chromosomally integrated human herpesvirus 6 among congenitally infected children.
  29. Crawford J, Kadom N, Santi M, Mariani B, Lavenstein B. Human herpesvirus 6 rhombencephalitis in immunocompetent children. J Child Neurol. 2007;22:1260-8 pubmed
    ..diagnostic workup, and neurologic outcome of 3 immunocompetent pediatric patients diagnosed with human herpesvirus 6 (HHV6) rhombencephalitis...
  30. Caselli E, Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiol. 2007;30:173-87 pubmed
    b>Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) are members of the Roseolovirus genus within the Betaherpesvirinae subfamily...
  31. Tohyama M, Hashimoto K, Yasukawa M, Kimura H, Horikawa T, Nakajima K, et al. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Br J Dermatol. 2007;157:934-40 pubmed
    ..The association of human herpesvirus (HHV)-6 reactivation with DIHS has been reported by various groups...
  32. Yoshinari S, Hamano S, Ito T, Eto Y. [MRI-diffusion weighted images of encephalopathy associated with human herpesvirus 6 infection]. No To Hattatsu. 2005;37:374-9 pubmed
    ..DWI may be a useful diagnostic procedure in the early stages of HHV-6 encephalopathy...
  33. Huang H, Kamijima M, Wang H, Li S, Yoshikawa T, Lai G, et al. Human herpesvirus 6 reactivation in trichloroethylene-exposed workers suffering from generalized skin disorders accompanied by hepatic dysfunction. J Occup Health. 2006;48:417-23 pubmed
    ..and C viruses, Mycoplasma pneumoniae, herpes simplex viruses 1 and 2, Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, measles and rubella virus...
  34. Mardivirin L, Valeyrie Allanore L, Branlant Redon E, Beneton N, Jidar K, Barbaud A, et al. Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro. Eur J Dermatol. 2010;20:68-73 pubmed publisher
    ..It is widely recognized that the reactivation of herpesviruses, including HHV-6 (Human Herpesvirus 6) and EBV (Epstein Barr virus) is associated with DRESS (Drug Reaction with Eosinophilia and Systemic ..
  35. Achour A, Malet I, Deback C, Bonnafous P, Boutolleau D, Gautheret Dejean A, et al. Length variability of telomeric repeat sequences of human herpesvirus 6 DNA. J Virol Methods. 2009;159:127-30 pubmed publisher
    The telomeric repeat sequences (TRS) located near both ends of human herpesvirus 6 (HHV-6) genome are unique structures of unknown function among human herpesviruses...
  36. Clark D, Nacheva E, Leong H, Brazma D, Li Y, Tsao E, et al. Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis. J Infect Dis. 2006;193:912-6 pubmed
    ..We suggest that the confounding influence of integration be considered in laboratory investigations associating HHV-6 with disease...
  37. Martinez A, Alvarez Lafuente R, Mas A, Bartolome M, Garcia Montojo M, De las Heras V, et al. Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA. Hum Immunol. 2007;68:685-9 pubmed
    ..Besides, this report indicates that when patients are grouped based upon a well-defined molecular event, complex diseases may reveal themselves as being constituted by distinct entities in which some genes may have a strong influence...
  38. Bigalke B, Klingel K, May A, Kandolf R, Gawaz M. Human herpesvirus 6 subtype A-associated myocarditis with 'apical ballooning'. Can J Cardiol. 2007;23:393-5 pubmed
    ..biopsies and polymerase chain reaction analysis of the plasma revealed an acute infection with human herpesvirus 6 subtype A...
  39. Nacheva E, Ward K, Brazma D, Virgili A, Howard J, Leong H, et al. Human herpesvirus 6 integrates within telomeric regions as evidenced by five different chromosomal sites. J Med Virol. 2008;80:1952-8 pubmed publisher
    Fluorescent in situ hybridization (FISH) was used to investigate the chromosomal integration sites of human herpesvirus 6 (HHV-6) in phytohemagglutinin-stimulated leukocytes and B lymphocytes from Epstein-Barr virus transformed ..
  40. Hüfner K, Arbusow V, Himmelein S, Derfuss T, Sinicina I, Strupp M, et al. The prevalence of human herpesvirus 6 in human sensory ganglia and its co-occurrence with alpha-herpesviruses. J Neurovirol. 2007;13:462-7 pubmed
    b>Human herpesvirus 6 (HHV-6) persists in the central nervous system, but its prevalence in the peripheral nervous system, a preferred latency site for herpesviruses, has not been studied...
  41. Kamble R, Clark D, Leong H, Heslop H, Brenner M, Carrum G. Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;40:563-6 pubmed
    b>Human herpesvirus 6 (HHV-6) viremia, as detected by polymerase chain amplification, occurs in approximately half of allogeneic hematopoietic stem cell transplant recipients...
  42. Pöhlmann C, Schetelig J, Reuner U, Bornhauser M, Illmer T, Kiani A, et al. Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient. Clin Infect Dis. 2007;44:e118-20 pubmed
    We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication...
  43. Gorniak R, Young G, Wiese D, Marty F, Schwartz R. MR imaging of human herpesvirus-6-associated encephalitis in 4 patients with anterograde amnesia after allogeneic hematopoietic stem-cell transplantation. AJNR Am J Neuroradiol. 2006;27:887-91 pubmed
    ..A frequent etiology seen in this context is human herpesvirus-6 (HHV6) infection. We report the evolution of MR imaging findings and clinical course in 4 patients with limbic encephalitis probably related to HHV6...
  44. Ihira M, Ohta A, Sugata K, Suga S, Asano Y, Yoshikawa T. Loop-mediated isothermal amplification for discriminating between human herpesvirus 6 A and B. J Virol Methods. 2008;154:223-5 pubmed publisher
    Genotyping of human herpesvirus 6 (HHV-6) is important clinically, particularly for the diagnosis of neurological diseases...
  45. Sugita S, Shimizu N, Kawaguchi T, Akao N, Morio T, Mochizuki M. Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis. Arch Ophthalmol. 2007;125:1426-7 pubmed
  46. Sullivan B, Coscoy L. Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein. J Virol. 2008;82:602-8 pubmed publisher
    We have performed a screen aimed at identifying human herpesvirus 6 (HHV-6)-encoded proteins that modulate immune recognition...
  47. Fotheringham J, Akhyani N, Vortmeyer A, Donati D, Williams E, Oh U, et al. Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid. J Infect Dis. 2007;195:450-4 pubmed
    ..Astrocytic cells positive for viral antigen provided support for an HHV-6-specific tropism for hippocampal astrocytes. HHV-6 DNA in CSF and serum may not reflect the level of active viral infection in the brain after BMT...
  48. MacLaine N, Oster B, Bundgaard B, Fraser J, Buckner C, Lazo P, et al. A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection. J Biol Chem. 2008;283:28563-73 pubmed publisher
  49. Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima T, et al. Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7. Microbiol Immunol. 2009;53:22-9 pubmed publisher
    ..The detection rate for each viral DNA was 6.7% for HSV, 9.5% for HHV-6, and 1.9% for HHV-7. These results indicate that our system is reliable and may be useful for the rapid diagnosis of viral encephalitis/encephalopathy...
  50. Provenzale J, VanLandingham K, Lewis D, Mukundan S, White L. Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging. Radiology. 2008;249:955-63 pubmed publisher
    To test the hypothesis that patterns of signal intensity abnormality in human herpesvirus 6 (HHV6)-positive patients would allow distinction from patients who did not test positive for HHV6 encephalitis.
  51. Takemoto M, Koike M, Mori Y, Yonemoto S, Sasamoto Y, Kondo K, et al. Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion. J Virol. 2005;79:13037-46 pubmed
    A mass spectroscopic analysis of proteins from human herpesvirus 6 (HHV-6)-infected cells showed that the HHV-6 U14 protein coimmunoprecipitated with the tumor suppressor p53...
  52. Laina I, Syriopoulou V, Daikos G, Roma E, Papageorgiou F, Kakourou T, et al. Febrile seizures and primary human herpesvirus 6 infection. Pediatr Neurol. 2010;42:28-31 pubmed publisher
    Primary human herpesvirus 6 infection is acquired mainly during the first two years of life and is often associated with febrile seizures...
  53. Ward K, Leong H, Thiruchelvam A, Atkinson C, Clark D. Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis. J Clin Microbiol. 2007;45:1298-304 pubmed
    The prevalence and concentration of human herpesvirus 6 (HHV-6) DNA in the cerebrospinal fluid (CSF) of the immunocompetent in primary infection was compared with that in viral chromosomal integration...
  54. Alvarez Lafuente R, De las Heras V, Bartolome M, Garcia Montojo M, Arroyo R. Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study. Brain Pathol. 2006;16:20-7 pubmed
    ..This study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS)...
  55. Chiou C, Chung W, Hung S, Yang L, Hong H. Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection. J Am Acad Dermatol. 2006;54:S14-7 pubmed
    ..In rare cases, fulminant type1 diabetes mellitus (DM) may develop after DHS. Among proposed pathogenesis, human herpesvirus 6 (HHV-6) infections may play a role in the development of DHS...
  56. Mameli G, Astone V, Arru G, Marconi S, Lovato L, Serra C, et al. Brains and peripheral blood mononuclear cells of multiple sclerosis (MS) patients hyperexpress MS-associated retrovirus/HERV-W endogenous retrovirus, but not Human herpesvirus 6. J Gen Virol. 2007;88:264-74 pubmed
    Multiple sclerosis (MS)-associated retrovirus (MSRV)/HERV-W (human endogenous retrovirus W) and Human herpesvirus 6 (HHV-6) are the two most studied (and discussed) viruses as environmental co-factors that trigger MS immunopathological ..
  57. Lacoste V, Verschoor E, Nerrienet E, Gessain A. A novel homologue of Human herpesvirus 6 in chimpanzees. J Gen Virol. 2005;86:2135-40 pubmed
    ..Indeed, intriguingly, no close simian homologue of the roseoloviruses Human herpesvirus 6 (HHV-6) and Human herpesvirus 7 (HHV-7), the other two human members of the Betaherpesvirinae, has been ..
  58. Jaworska J, Gravel A, Fink K, Grandvaux N, Flamand L. Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein. J Virol. 2007;81:5737-48 pubmed
  59. Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int. 2006;55:1-8 pubmed
    ..Recent studies suggest an intimate relationship between reactivations of herpesviruses including human herpesvirus 6 (HHV-6) and the development of a severe systemic hypersensitivity reaction referred to as drug-induced ..
  60. Tang H, Kawabata A, Takemoto M, Yamanishi K, Mori Y. Human herpesvirus-6 infection induces the reorganization of membrane microdomains in target cells, which are required for virus entry. Virology. 2008;378:265-71 pubmed publisher
    ..These data suggest that cellular-membrane lipid rafts are important in viral entry and that HHV-6 may enter the target cells via the rafts...
  61. Yoshikawa T. [Human herpesvirus 6 encephalitis]. Brain Nerve. 2010;62:869-75 pubmed
    Primary human herpesvirus 6 (HHV-6) infection causes exanthem subitum,a common febrile illness,in infants. At the time of primary infection with HHV-6, the virus rarely causes encephalitis...
  62. Ihira M, Akimoto S, Miyake F, Fujita A, Sugata K, Suga S, et al. Direct detection of human herpesvirus 6 DNA in serum by the loop-mediated isothermal amplification method. J Clin Virol. 2007;39:22-6 pubmed
    A more rapid and easier method is needed for monitoring human herpesvirus 6 (HHV-6) infections...
  63. Yoshikawa T. Human herpesvirus 6 causes hepatitis in transplant recipients. Intern Med. 2006;45:417-8 pubmed
  64. Caruso A, Caselli E, Fiorentini S, Rotola A, Prandini A, Garrafa E, et al. U94 of human herpesvirus 6 inhibits in vitro angiogenesis and lymphangiogenesis. Proc Natl Acad Sci U S A. 2009;106:20446-51 pubmed publisher
    b>Human herpesvirus 6 (HHV-6) is a lymphotropic virus, but recent observations showed that also vascular endothelial cells (ECs) are susceptible to infection, both in vivo and in vitro...
  65. Fujimaki K, Mori T, Kida A, Tanaka M, Kawai N, Matsushima T, et al. Human herpesvirus 6 meningoencephalitis in allogeneic hematopoietic stem cell transplant recipients. Int J Hematol. 2006;84:432-7 pubmed
    We retrospectively investigated the clinical characteristics of human herpesvirus 6 (HHV-6) meningoencephalitis within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT)...
  66. Huang H, Li Y, Sadaoka T, Tang H, Yamamoto T, Yamanishi K, et al. Human herpesvirus 6 envelope cholesterol is required for virus entry. J Gen Virol. 2006;87:277-85 pubmed
    In this study, the role of cholesterol in the envelope of human herpesvirus 6 (HHV-6) was examined by using methyl-beta-cyclodextrin (MbetaCD) depletion...
  67. Niiya H, Lei J, Guo Y, Azuma T, Yakushijin Y, Sakai I, et al. Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells. Exp Hematol. 2006;34:642-53 pubmed
    ..b>Human herpesvirus 6 (HHV-6) infects monocytes and is reactivated in immunodeficient patients...
  68. Kuntzen T, Friedrichs N, Fischer H, Eis Hubinger A, Sauerbruch T, Spengler U. Postinfantile giant cell hepatitis with autoimmune features following a human herpesvirus 6-induced adverse drug reaction. Eur J Gastroenterol Hepatol. 2005;17:1131-4 pubmed
    ..We present a patient with GCH with autoimmune features after a human herpesvirus 6 (HHV6)-induced adverse drug reaction, a combination that has not been reported before...
  69. Luppi M, Barozzi P, Bosco R, Vallerini D, Potenza L, Forghieri F, et al. Human herpesvirus 6 latency characterized by high viral load: chromosomal integration in many, but not all, cells. J Infect Dis. 2006;194:1020-1; author reply 1021-3 pubmed
  70. Vianello F, Barbaro F, Cogo P, Furlan A, Trevenzoli M, Sgarabotto D. Co-infection with Mycoplasma pneumoniae and human herpesvirus 6 (HHV-6) in an immunocompetent child with meningoencephalitis: a random association?. Infection. 2008;36:174-6 pubmed
    ..The hypothetical relationship between this dual infection and the central nervous system disease is discussed...
  71. Tomoiu A, Gravel A, Tanguay R, Flamand L. Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation. J Virol. 2006;80:10218-28 pubmed publisher
    The immediate-early 2 (IE2) protein of human herpesvirus 6 is a potent transactivator of cellular and viral promoters...
  72. Canpolat Kirac B, Adisen E, Bozdayi G, Yucel A, Fidan I, Aksakal N, et al. The role of human herpesvirus 6, human herpesvirus 7, Epstein-Barr virus and cytomegalovirus in the aetiology of pityriasis rosea. J Eur Acad Dermatol Venereol. 2009;23:16-21 pubmed publisher
    To identify the role of human herpesvirus 6 (HHV-6), HHV-7, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in the pathogenesis of pityriasis rosea (PR).
  73. Sullivan B, Coscoy L. The U24 protein from human herpesvirus 6 and 7 affects endocytic recycling. J Virol. 2010;84:1265-75 pubmed publisher
    ..Inhibition of a basic cellular process by U24 has interesting implications not only for the pathogenicity of roseoloviruses but also for our understanding of the biology of endosomal transport...
  74. Broccolo F, Drago F, Paolino S, Cassina G, Gatto F, Fusetti L, et al. Reactivation of human herpesvirus 6 (HHV-6) infection in patients with connective tissue diseases. J Clin Virol. 2009;46:43-6 pubmed publisher
    ..Little is known about the involvement of human herpesviruses 6 and 7 (HHV-6 and HHV-7) in autoimmune connective tissue diseases (ACTD)...
  75. Turcanova V, Bundgaard B, Höllsberg P. Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen. J Clin Virol. 2009;46:15-9 pubmed publisher
    ..Its expression is transactivated in B cells during infection with Epstein-Barr virus and in peripheral blood mononuclear cells (PBMCs) that are treated with IFN-alpha...