muromegalovirus

Summary

Summary: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, causing infection involving several organs in mice and rats. Murid herpesvirus is the type species.

Top Publications

  1. Mintern J, Klemm E, Wagner M, Paquet M, Napier M, Kim Y, et al. Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1. J Immunol. 2006;177:8422-31 pubmed
    ..These results show a novel function for m138 in MCMV infection and identify the first viral protein to target B7-1...
  2. Kielczewska A, Kim H, Lanier L, Dimasi N, Vidal S. Critical residues at the Ly49 natural killer receptor's homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like protein. J Immunol. 2007;178:369-77 pubmed
    ..These results link Ly49 homodimerization variability to the direct recognition of pathogen products. ..
  3. Brune W. Inhibition of programmed cell death by cytomegaloviruses. Virus Res. 2011;157:144-50 pubmed publisher
    ..This review summarizes our current understanding of how the CMVs suppress PCD and which signaling pathways they target...
  4. Buck A, Santoyo Lopez J, Robertson K, Kumar D, Reczko M, Ghazal P. Discrete clusters of virus-encoded micrornas are associated with complementary strands of the genome and the 7.2-kilobase stable intron in murine cytomegalovirus. J Virol. 2007;81:13761-70 pubmed
    ..One cluster of miRNAs occurs in close proximity to the 5' splice site of the previously identified 7.2-kb stable intron, implying a variety of potential regulatory mechanisms for MCMV miRNAs. ..
  5. Campbell A, Cavanaugh V, Slater J. The salivary glands as a privileged site of cytomegalovirus immune evasion and persistence. Med Microbiol Immunol. 2008;197:205-13 pubmed publisher
    ..However, this mechanism is severely dampened by high levels of the immunosuppressive cytokine IL-10, selectively expressed by SG CD4+ T cells. ..
  6. Qian Z, Xuan B, Chapa T, Gualberto N, Yu D. Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response. J Virol. 2012;86:6712-23 pubmed publisher
    ..This work sets the stage for using the MCMV model to explore the role of this stress response in CMV biology, particularly during infection of the host, which is difficult to study in HCMV...
  7. Munks M, Pinto A, Doom C, Hill A. Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infection. J Immunol. 2007;178:7235-41 pubmed
    ..Overall, the data indicate that the presence or absence of MHC I immune evasion genes has remarkably little impact on the size or specificity of the MCMV-specific CD8 T cell response over an entire lifetime of infection. ..
  8. Liu X, Yan S, Abecassis M, Hummel M. Establishment of murine cytomegalovirus latency in vivo is associated with changes in histone modifications and recruitment of transcriptional repressors to the major immediate-early promoter. J Virol. 2008;82:10922-31 pubmed publisher
  9. Zhi L, Mans J, Paskow M, Brown P, Schuck P, Jonjić S, et al. Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms. Biochemistry. 2010;49:2443-53 pubmed publisher
    ..Molecular modeling of the different RAE-1 isoforms suggests a potential site for the m152 interaction. ..

More Information

Publications101 found, 100 shown here

  1. Babic M, Pyzik M, Zafirova B, Mitrovic M, Butorac V, Lanier L, et al. Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo. J Exp Med. 2010;207:2663-73 pubmed publisher
  2. Sun J, Lanier L. Cutting edge: viral infection breaks NK cell tolerance to "missing self". J Immunol. 2008;181:7453-7 pubmed
    ..Thus, although NK cells can be held in check against "missing self," acute inflammation driven by infection can rapidly break established self-tolerance. ..
  3. Xie X, Stadnisky M, Brown M. MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance to murine cytomegalovirus. J Immunol. 2009;182:7163-71 pubmed publisher
    ..M-H2(k)(R7). We conclude that the MHC class I D locus prompts expansion and activation of Ly49G2(+) NK cells that are needed in H-2(k) MCMV resistance. ..
  4. Corbett A, Forbes C, Moro D, Scalzo A. Extensive sequence variation exists among isolates of murine cytomegalovirus within members of the m02 family of genes. J Gen Virol. 2007;88:758-69 pubmed
    ..As this variation among strains may alter the function of genes, these findings should be considered when analysing gene function or host-virus interactions in laboratory models. ..
  5. Lemmermann N, Gergely K, Böhm V, Deegen P, Däubner T, Reddehase M. Immune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes. J Virol. 2010;84:1221-36 pubmed publisher
    ..The data suggest that pMHC complexes present at the cell surface in advance of immunoevasin gene expression are downmodulated due to constitutive turnover in the absence of resupply. ..
  6. Strobl B, Bubic I, Bruns U, Steinborn R, Lajko R, Kolbe T, et al. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol. 2005;175:4000-8 pubmed
    ..In addition to the established role of Tyk2 as an amplifier of Jak/Stat signaling upon IFN-alphabeta stimulation, we provide evidence for a novel role of Tyk2 as a modifier of host responses. ..
  7. Blanc M, Hsieh W, Robertson K, Watterson S, Shui G, Lacaze P, et al. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. PLoS Biol. 2011;9:e1000598 pubmed publisher
    ..These findings bring a new link between sterol metabolism and interferon antiviral response and support the idea of using host metabolic modifiers of innate immunity as a potential antiviral strategy. ..
  8. Smith L, Shellam G, Redwood A. Genes of murine cytomegalovirus exist as a number of distinct genotypes. Virology. 2006;352:450-65 pubmed
    ..5, m152) were highly conserved, others (m04, m06, M44, m138, m144, m145 and m155) contained significant sequence variation. Several of these genes (m06, m144 and m155) exist in wild MCMV strains as one of several distinct genotypes. ..
  9. Tang Q, Murphy E, Maul G. Experimental confirmation of global murine cytomegalovirus open reading frames by transcriptional detection and partial characterization of newly described gene products. J Virol. 2006;80:6873-82 pubmed
    ..Analysis of two ORFs using site-directed mutagenesis showed that deletion of one of the mitochondrion-localized gene products led to significantly decreased replication in fibroblasts. ..
  10. Hokeness K, Deweerd E, Munks M, Lewis C, Gladue R, Salazar Mather T. CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection. J Virol. 2007;81:1241-50 pubmed
    ..Thus, CXCR3-mediated signals support the accumulation of MCMV-specific CD8 T cells that contribute to, but are not exclusively required for, protective responses in a virus-infected tissue site. ..
  11. Upton J, Kaiser W, Mocarski E. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe. 2010;7:302-13 pubmed publisher
  12. Jones M, Ladell K, Wynn K, Stacey M, Quigley M, Gostick E, et al. IL-10 restricts memory T cell inflation during cytomegalovirus infection. J Immunol. 2010;185:3583-92 pubmed publisher
    ..These data demonstrate that regulatory immune mechanisms can influence CMV-specific T cell memory and suggest a possible rationale for the acquisition of functional IL-10 orthologs by herpesviruses. ..
  13. Snyder C, Loewendorf A, Bonnett E, Croft M, Benedict C, Hill A. CD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection. J Immunol. 2009;183:3932-41 pubmed publisher
    ..These data show that CD4(+) T cell help is needed for inflation of a response that develops only during chronic infection but is otherwise dispensable for the steady state maintenance and function of MCMV-specific CD8(+) T cells. ..
  14. Mohr C, Arapovic J, Mühlbach H, Panzer M, Weyn A, Dölken L, et al. A spread-deficient cytomegalovirus for assessment of first-target cells in vaccination. J Virol. 2010;84:7730-42 pubmed publisher
    ..Furthermore, genomes of MCMV-DeltaM94 were present in lungs 12 months after infection, revealing first-target cells as sites of genome maintenance. ..
  15. Tripathy S, Smith H, Holroyd E, Pingel J, Yokoyama W. Expression of m157, a murine cytomegalovirus-encoded putative major histocompatibility class I (MHC-I)-like protein, is independent of viral regulation of host MHC-I. J Virol. 2006;80:545-50 pubmed
    ..MCMV-encoded proteins that down-regulate MHC-I did not affect the expression of m157. Thus, m157 is expressed on infected cells in a manner independent of viral regulation of host MHC-I. ..
  16. Kulesza C, Shenk T. Murine cytomegalovirus encodes a stable intron that facilitates persistent replication in the mouse. Proc Natl Acad Sci U S A. 2006;103:18302-7 pubmed
    ..e., little virus was detected in the salivary gland at 14 days after infection. The intron functions as an in vivo virulence factor, facilitating progression from the acute to persistent phase of infection. ..
  17. Manzur M, Fleming P, Huang D, Degli Esposti M, Andoniou C. Virally mediated inhibition of Bax in leukocytes promotes dissemination of murine cytomegalovirus. Cell Death Differ. 2009;16:312-20 pubmed publisher
    ..These results establish that in vivo MCMV replication induces the activation of Bax in leukocytes, but not other permissive cells, and that MCMV interferes with this process to attain maximum dissemination. ..
  18. Vomaske J, Denton M, Kreklywich C, Andoh T, Osborn J, Chen D, et al. Cytomegalovirus CC chemokine promotes immune cell migration. J Virol. 2012;86:11833-44 pubmed publisher
    ..Together our findings indicate that RCMV r129 is highly chemotactic, which has important implications during RCMV infection and reactivation and acceleration of TVS...
  19. Tsutsui Y, Kosugi I, Kawasaki H. Neuropathogenesis in cytomegalovirus infection: indication of the mechanisms using mouse models. Rev Med Virol. 2005;15:327-45 pubmed
    ..It has also been shown that CMV infection in developing brains may become latent in neural immature cells. Brain disorders may occur long after infection by reactivation of the latent infection. ..
  20. Delale T, Paquin A, Asselin Paturel C, Dalod M, Brizard G, Bates E, et al. MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo. J Immunol. 2005;175:6723-32 pubmed
  21. Mitrovic M, Arapovic J, Jordan S, Fodil Cornu N, Ebert S, Vidal S, et al. The NK cell response to mouse cytomegalovirus infection affects the level and kinetics of the early CD8(+) T-cell response. J Virol. 2012;86:2165-75 pubmed publisher
  22. Cheeran M, Gekker G, Hu S, Palmquist J, Lokensgard J. T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-gamma. J Neurovirol. 2005;11:274-80 pubmed
    ..These data indicate that peripheral CD8+ T cells control MCMV brain infection through a perforin-mediated mechanism and that neither IFN-gamma nor CXCR3 play a critical role in this neuroprotective response. ..
  23. Marcinowski L, Tanguy M, Krmpotic A, Rädle B, Lisnić V, Tuddenham L, et al. Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo. PLoS Pathog. 2012;8:e1002510 pubmed publisher
  24. Bozza S, Bistoni F, Gaziano R, Pitzurra L, Zelante T, Bonifazi P, et al. Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation. Blood. 2006;108:3387-96 pubmed
  25. Liu X, Yan S, Abecassis M, Hummel M. Biphasic recruitment of transcriptional repressors to the murine cytomegalovirus major immediate-early promoter during the course of infection in vivo. J Virol. 2010;84:3631-43 pubmed publisher
    ..The observation that repressors are bound to the MIEP and other promoters immediately upon infection suggests that latency may be established in some cells very early in infection. ..
  26. Abraham C, Kulesza C. Polycomb repressive complex 2 targets murine cytomegalovirus chromatin for modification and associates with viral replication centers. PLoS ONE. 2012;7:e29410 pubmed publisher
    ..Together, our results suggest a novel, dynamic interaction between PcG epigenetic repressors and MCMV genomes. ..
  27. Jonjic S, Babic M, Polic B, Krmpotic A. Immune evasion of natural killer cells by viruses. Curr Opin Immunol. 2008;20:30-8 pubmed publisher
    ..Improving our understanding of viral regulation of NK cell function could be essential for designing more efficient measures in the prophylaxis and treatment of virus-induced pathology. ..
  28. Maninger S, Bosse J, Lemnitzer F, Pogoda M, Mohr C, von Einem J, et al. M94 is essential for the secondary envelopment of murine cytomegalovirus. J Virol. 2011;85:9254-67 pubmed publisher
    ..In addition, deletion of M94 resulted in a block of cell-to-cell spread. Moreover, the dominant negative mutant of M94 demonstrated a defect in interacting with M99, the UL11 homologue of MCMV. ..
  29. Adams E, Juo Z, Venook R, Boulanger M, Arase H, Lanier L, et al. Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors. Proc Natl Acad Sci U S A. 2007;104:10128-33 pubmed
    ..Collectively, our results show that m157 represents a structurally divergent form of MHC class I-like proteins that directly engage Ly49 receptors with appreciable affinity in a noncanonical fashion. ..
  30. Mohr H, Mohr C, Schneider M, Scrivano L, Adler B, Kraner Schreiber S, et al. Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo. PLoS Pathog. 2012;8:e1002728 pubmed publisher
    ..This conditional system was operative in explant cultures of transgenic mice, but not in vivo. Several applications are discussed. ..
  31. Cicin Sain L, Brien J, Uhrlaub J, Drabig A, Marandu T, Nikolich Zugich J. Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. PLoS Pathog. 2012;8:e1002849 pubmed publisher
    ..Therefore, latent MCMV infection resulted in pronounced changes of the T-cell compartment consistent with impaired naïve T-cell function...
  32. Tang Q, Maul G. Mouse cytomegalovirus crosses the species barrier with help from a few human cytomegalovirus proteins. J Virol. 2006;80:7510-21 pubmed
  33. Humphreys I, Loewendorf A, De Trez C, Schneider K, Benedict C, Munks M, et al. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism. J Immunol. 2007;179:2195-202 pubmed
    ..Collectively, these results indicate manipulation of OX40 may be useful in improving cellular immunotherapy regimes for treatment of persistent virus infections...
  34. Hsu K, Pratt J, Akers W, Achilefu S, Yokoyama W. Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. J Gen Virol. 2009;90:33-43 pubmed publisher
    ..On the other hand, cowpox virus showed a different pattern of infectivity in the spleen and liver. Thus, early MCMV infection produces a distinct pattern of infection of selective cells...
  35. Schumacher U, Handke W, Jurak I, Brune W. Mutations in the M112/M113-coding region facilitate murine cytomegalovirus replication in human cells. J Virol. 2010;84:7994-8006 pubmed publisher
    ..These results reveal a previously unrecognized role of the viral E1 proteins in regulating viral replication in different cells and provide new insights into the mechanisms of the species specificity of cytomegaloviruses...
  36. Swiecki M, Gilfillan S, Vermi W, Wang Y, Colonna M. Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual. Immunity. 2010;33:955-66 pubmed publisher
    ..We conclude that pDCs mediate early antiviral IFN-I responses and influence the accrual of virus-specific NK or CD8(+) T cells in a virus-dependent manner...
  37. Lacaze P, Forster T, Ross A, Kerr L, Salvo Chirnside E, Lisnic V, et al. Temporal profiling of the coding and noncoding murine cytomegalovirus transcriptomes. J Virol. 2011;85:6065-76 pubmed publisher
    ..Evidence is also presented to show, for the first time, genome-wide noncoding and bidirectional transcription at late stages of MCMV infection...
  38. Fliss P, Jowers T, Brinkmann M, Holstermann B, Mack C, Dickinson P, et al. Viral mediated redirection of NEMO/IKK? to autophagosomes curtails the inflammatory cascade. PLoS Pathog. 2012;8:e1002517 pubmed publisher
    ..We propose that the selective and irreversible degradation of a central regulatory protein by autophagy represents a new viral strategy to dampen the inflammatory response...
  39. Dighe A, Rodriguez M, Sabastian P, Xie X, McVoy M, Brown M. Requisite H2k role in NK cell-mediated resistance in acute murine cytomegalovirus-infected MA/My mice. J Immunol. 2005;175:6820-8 pubmed
    ..Taken together, effective NK cell-mediated MCMV control in this genetic system required polymorphic H2k genes without need of Ly49H-m157 interactions...
  40. Salazar Mather T, Hokeness K. Cytokine and chemokine networks: pathways to antiviral defense. Curr Top Microbiol Immunol. 2006;303:29-46 pubmed
    ..The studies highlighted in this chapter illustrate in vivo pathways mediated by innate cytokines in regulating chemokine responses that are vital for localized antiviral defenses...
  41. Mohr C, Cicin Sain L, Wagner M, Sacher T, Schnee M, Ruzsics Z, et al. Engineering of cytomegalovirus genomes for recombinant live herpesvirus vaccines. Int J Med Microbiol. 2008;298:115-25 pubmed
    ..With regard to a rational approach of virus attenuation, we consider a selective deletion of viral genes that modulate the immune response of the host...
  42. Wiebusch L, Neuwirth A, Grabenhenrich L, Voigt S, Hagemeier C. Cell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells. J Virol. 2008;82:10188-98 pubmed publisher
  43. Snyder C, Allan J, Bonnett E, Doom C, Hill A. Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells. PLoS ONE. 2010;5:e9681 pubmed publisher
    ..Our data support the conclusion that cross-presentation is the primary mode of antigen presentation by which CD8+ T cells are primed during MCMV infection...
  44. Robbins S, Bessou G, Cornillon A, Zucchini N, Rupp B, Ruzsics Z, et al. Natural killer cells promote early CD8 T cell responses against cytomegalovirus. PLoS Pathog. 2007;3:e123 pubmed
    ..Thus, the extent to which NK cell responses benefit the host goes beyond their direct antiviral effects and extends to the prevention of innate cytokine shock and to the promotion of adaptive immunity...
  45. Zucchini N, Bessou G, Robbins S, Chasson L, Raper A, Crocker P, et al. Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection. Int Immunol. 2008;20:45-56 pubmed
    ..These observations must be taken into account when designing new antiviral vaccination strategies aimed at harnessing pDC responses...
  46. Jonjic S, Krmpotic A, Arapovic J, Koszinowski U. Dissection of the antiviral NK cell response by MCMV mutants. Methods Mol Biol. 2008;415:127-49 pubmed publisher
    ..Here, we describe procedures to assess the NK cell response to mouse cytomegalovirus (MCMV), a prominent virus model for studying NK cell functions in vivo...
  47. Mutnal M, Cheeran M, Hu S, Lokensgard J. Murine cytomegalovirus infection of neural stem cells alters neurogenesis in the developing brain. PLoS ONE. 2011;6:e16211 pubmed publisher
    ..This investigation focused on, analysis of cell types infected with mouse cytomegalovirus (MCMV) and the pattern of injury to the developing brain...
  48. Walton S, Torti N, Mandarić S, Oxenius A. T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency. Eur J Immunol. 2011;41:2248-59 pubmed publisher
    ..Thus, CD8(+) T-cell inflation during latent CMV infection is strongly dependent on CD4(+) T-cell helper functions, which can partially be compensated by ongoing lytic viral replication in the absence of CD4(+) T cells...
  49. Tang Feldman Y, Wojtowicz A, Lochhead G, Hale M, Li Y, Pomeroy C. Use of quantitative real-time PCR (qRT-PCR) to measure cytokine transcription and viral load in murine cytomegalovirus infection. J Virol Methods. 2006;131:122-9 pubmed
    ..In summary, qRT-PCR is a sensitive and accurate method to study MCMV infection and host responses to the virus...
  50. Andoniou C, van Dommelen S, Voigt V, Andrews D, Brizard G, Asselin Paturel C, et al. Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat Immunol. 2005;6:1011-9 pubmed
    ..Notably, adoptive transfer of MCMV-activated CD11b(+) DCs resulted in improved control of MCMV infection, indicating that these cells participate in controlling viral replication in vivo...
  51. Lu X, Kavanagh D, Hill A. Cellular and molecular requirements for association of the murine cytomegalovirus protein m4/gp34 with major histocompatibility complex class I molecules. J Virol. 2006;80:6048-55 pubmed
  52. Cicin Sain L, Bubic I, Schnee M, Ruzsics Z, Mohr C, Jonjic S, et al. Targeted deletion of regions rich in immune-evasive genes from the cytomegalovirus genome as a novel vaccine strategy. J Virol. 2007;81:13825-34 pubmed
    ..Vaccination induced MCMV-specific antibodies and a strong T-cell response. We propose that a targeted and rational approach can improve future herpesvirus vaccines and vaccine vectors...
  53. Arnoult D, Skaletskaya A, Estaquier J, Dufour C, Goldmacher V. The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization. Apoptosis. 2008;13:1100-10 pubmed publisher
  54. Torti N, Walton S, Murphy K, Oxenius A. Batf3 transcription factor-dependent DC subsets in murine CMV infection: differential impact on T-cell priming and memory inflation. Eur J Immunol. 2011;41:2612-8 pubmed publisher
    ..These results highlight differential antigen presentation requirements during acute and latent MCMV infection...
  55. Szomolanyi Tsuda E, Liang X, Welsh R, Kurt Jones E, Finberg R. Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo. J Virol. 2006;80:4286-91 pubmed
    ..Our studies suggest that in addition to the reported involvement of TLR9 and TLR3, TLR2 is also involved in innate immune responses to MCMV infection...
  56. Wesley J, Tessmer M, Chaukos D, Brossay L. NK cell-like behavior of Valpha14i NK T cells during MCMV infection. PLoS Pathog. 2008;4:e1000106 pubmed publisher
    ..Collectively, these findings illustrate the plasticity of Valpha14i NK T cells that act as effector T cells during bacterial infection, but have NK cell-like behavior during the innate immune response to MCMV infection...
  57. Lembo D, Brune W. Tinkering with a viral ribonucleotide reductase. Trends Biochem Sci. 2009;34:25-32 pubmed publisher
    ..The discovery of this novel mechanism of viral immune subversion provides further support to the concept of evolutionary tinkering...
  58. Madan R, Demircik F, Surianarayanan S, Allen J, Divanovic S, Trompette A, et al. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol. 2009;183:2312-20 pubmed publisher
  59. Loh H, Mohd Lila M, Abdul Rahman S, Kiew L. Pathogenesis and vertical transmission of a transplacental rat cytomegalovirus. Virol J. 2006;3:42 pubmed
    ..The rat placenta, resembling histologically to that of human, could therefore facilitate the study of CMV congenital infection in human...
  60. Sacher T, Jordan S, Mohr C, Vidy A, Weyn A, Ruszics Z, et al. Conditional gene expression systems to study herpesvirus biology in vivo. Med Microbiol Immunol. 2008;197:269-76 pubmed publisher
    ..Furthermore, the deletion of viral genes can be used to screen for cell type-specificity of viral gene functions. Hence, conditional MCMV mutants allow the study of herpesvirus biology on the level of cell types in vivo...
  61. Cardin R, Schaefer G, Allen J, Davis Poynter N, Farrell H. The M33 chemokine receptor homolog of murine cytomegalovirus exhibits a differential tissue-specific role during in vivo replication and latency. J Virol. 2009;83:7590-601 pubmed publisher
    ..Our data suggest that M33 contributes to the efficient establishment or maintenance of long-term latent MCMV infection...
  62. Fossum E, Friedel C, Rajagopala S, Titz B, Baiker A, Schmidt T, et al. Evolutionarily conserved herpesviral protein interaction networks. PLoS Pathog. 2009;5:e1000570 pubmed publisher
    ..By combining interactomes of different species we were able to systematically address the low coverage of the Y2H system and to extract biologically relevant interactions which were not evident from single species...
  63. Mutnal M, Cheeran M, Hu S, Little M, Lokensgard J. Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice. J Neuroimmunol. 2010;227:101-10 pubmed publisher
    ..Collectively, these data indicate that the absence of IL-10 results in pathologic neutrophil infiltration into MCMV-infected brains...
  64. Tessmer M, Reilly E, Brossay L. Salivary gland NK cells are phenotypically and functionally unique. PLoS Pathog. 2011;7:e1001254 pubmed publisher
    ..Altogether, these results indicate that viral persistence and latency in the salivary glands may be due in part to the presence of unfit NK cells and the lack of recruitment of peripheral NK cells...
  65. Sun J, Madera S, Bezman N, Beilke J, Kaplan M, Lanier L. Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J Exp Med. 2012;209:947-54 pubmed publisher
    ..Understanding the full contribution of inflammatory cytokine signaling to the NK cell response against viral infection will be of interest for the development of vaccines and therapeutics...
  66. Reuter J, Wilson J, Idoko K, van den Pol A. CD4+ T-cell reconstitution reduces cytomegalovirus in the immunocompromised brain. J Virol. 2005;79:9527-39 pubmed
    ..Systemic adoptive transfer may be a rapid and effective approach to preventing CMV entrance into the brain and for reducing neurotropic infection...
  67. Sjölin H, Robbins S, Bessou G, Hidmark A, Tomasello E, Johansson M, et al. DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection. J Immunol. 2006;177:2908-16 pubmed
    ..The potential implications of the regulation of pDC functions by DAP12 for promoting health over disease are discussed...
  68. Buser C, Walther P, Mertens T, Michel D. Cytomegalovirus primary envelopment occurs at large infoldings of the inner nuclear membrane. J Virol. 2007;81:3042-8 pubmed
    ..This is a previously undescribed structural element relevant in cytomegalovirus morphogenesis...
  69. Zucchini N, Bessou G, Traub S, Robbins S, Uematsu S, Akira S, et al. Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection. J Immunol. 2008;180:5799-803 pubmed
    ..This is the first demonstration of the implication of TLR7 in the recognition of a DNA virus...
  70. Bantug G, Cekinovic D, Bradford R, Koontz T, Jonjic S, Britt W. CD8+ T lymphocytes control murine cytomegalovirus replication in the central nervous system of newborn animals. J Immunol. 2008;181:2111-23 pubmed
    ..In summary, these results show that functionally mature virus-specific CD8(+) T cells are recruited to the CNS in mice infected with MCMV as neonates...
  71. Klenerman P, Dunbar P. CMV and the art of memory maintenance. Immunity. 2008;29:520-2 pubmed publisher
    ..quot; In this issue of Immunity, Snyder et al. (2008) examine the dynamics of memory inflation and demonstrate continuous turnover of inflating T cells, drawing on both memory cells and naive cells to replace them...
  72. Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen M, Munks M, et al. Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response. J Exp Med. 2009;206:515-23 pubmed publisher
    ..These findings reveal a novel mechanism of major histocompatibility complex class I-restricted recognition of virally infected cells by an activating NK cell receptor...
  73. Jordan S, Krause J, Prager A, Mitrovic M, Jonjic S, Koszinowski U, et al. Virus progeny of murine cytomegalovirus bacterial artificial chromosome pSM3fr show reduced growth in salivary Glands due to a fixed mutation of MCK-2. J Virol. 2011;85:10346-53 pubmed publisher
    ..We conclude that the MCK-2 mutation in the pSM3fr BAC is the result of clonal selection during the BAC cloning procedure...
  74. Farroway L, Gorman S, Lawson M, Harvey N, Jones D, Shellam G, et al. Transmission of two Australian strains of murine cytomegalovirus (MCMV) in enclosure populations of house mice (Mus domesticus). Epidemiol Infect. 2005;133:701-10 pubmed
    ..Thus, prior immunity to N1 did not prevent transmission of G4. This result is promising for successful transmission of an immunocontraceptive vaccine through Australian mouse populations where MCMV infection is endemic...
  75. Xie X, Dighe A, Clark P, Sabastian P, Buss S, Brown M. Deficient major histocompatibility complex-linked innate murine cytomegalovirus immunity in MA/My.L-H2b mice and viral downregulation of H-2k class I proteins. J Virol. 2007;81:229-36 pubmed
  76. Hokeness Antonelli K, Crane M, Dragoi A, Chu W, Salazar Mather T. IFN-alphabeta-mediated inflammatory responses and antiviral defense in liver is TLR9-independent but MyD88-dependent during murine cytomegalovirus infection. J Immunol. 2007;179:6176-83 pubmed
    ..Collectively, our results define contrasting compartmental functions for TLR9 and MyD88, and suggest that the infected tissue site uniquely contributes to the process of virus sensing and regulation of localized antiviral responses...
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    ..Moreover, the fact that MCMV-infected cells are protected from both Bak- and Bax-mediated cell death suggests that MCMV possesses an additional, as-yet-unidentified mechanism to block Bak-mediated apoptosis...
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    ..It is apparent that the previously described host resistance patterns of inbred mice and MCMV are not consistently applicable for all MCMV strains...
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    ..As an important consequence, these findings predict that deletion of immunoevasin genes in a replicative vaccine virus is not a favorable option but may, rather, be counterproductive...
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    ..Taken together, these results confirm the pivotal role of the Ly49H receptor during MCMV infection and open the way for further investigations in host-pathogen interactions...
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    ..We conclude that the ie1 gene is not essential for the establishment of latency or for the reactivation of MCMV...
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    ..The lethal phenotype of several insertion and stop mutants indicated the functional importance of the C terminus of the protein...
  83. Jurak I, Brune W. Induction of apoptosis limits cytomegalovirus cross-species infection. EMBO J. 2006;25:2634-42 pubmed
    ..Moreover, the same principle facilitates replication of the rat cytomegalovirus in human cells. Thus, induction of apoptosis serves as an innate immune defense to inhibit cross-species infections of rodent CMVs...
  84. Dölken L, Perot J, Cognat V, Alioua A, John M, Soutschek J, et al. Mouse cytomegalovirus microRNAs dominate the cellular small RNA profile during lytic infection and show features of posttranscriptional regulation. J Virol. 2007;81:13771-82 pubmed
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    ..In addition, HCMV UL33 was found to partially compensate for the lack of M33 in vivo, suggesting conserved biological roles of the UL33 gene family...
  86. Tripathy S, Keyel P, Yang L, Pingel J, Cheng T, Schneeberger A, et al. Continuous engagement of a self-specific activation receptor induces NK cell tolerance. J Exp Med. 2008;205:1829-41 pubmed publisher
    ..Thus, engagement of self-specific activation receptors in vivo induces an NK cell tolerance effect that is not affected by self-MHC-specific inhibitory receptors...
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    ..Thus, these data show that memory inflation is maintained by a continuous replacement of short-lived, functional cells during chronic MCMV infection...
  88. Tassi I, Le Friec G, Gilfillan S, Takai T, Yokoyama W, Colonna M. DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo. Eur J Immunol. 2009;39:1129-35 pubmed publisher
    ..Thus, while many activating NK-cell receptors are promiscuous in terms of adaptor association, our data indicate that the functional consequences of such promiscuity may vary widely and may not be evident in all cases...
  89. Arapovic J, Lenac T, Antulov R, Polic B, Ruzsics Z, Carayannopoulos L, et al. Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus. J Virol. 2009;83:8198-207 pubmed publisher
    ..This difference can be attributed to the absence of a PLWY motif from RAE-1delta. Altogether, these findings provide evidence for a novel mechanism of host escape from viral immunoevasion of NKG2D-dependent control...
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    ..Our results suggest that the interactions of IE3 with IE3AM and with TBP stabilize the TFIID complex at the M112-113 promoter such that M112-113 gene expression can be activated and/or enhanced...
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    ..The reported findings make a major contribution to our molecular understanding of enhanced CMV pathogenicity in the multiply infected host...
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    ..This allowed us to study the role of endothelial cells and hepatocytes for virus dissemination and will permit detailed studies on innate and adaptive immune responses to CMV...