varicellovirus

Summary

Summary: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE. Its species include those causing CHICKENPOX and HERPES ZOSTER in humans (HERPESVIRUS 3, HUMAN), as well as several animal viruses.

Top Publications

  1. Keel M, Patterson J, Noon T, Bradley G, Collins J. Caprine herpesvirus-2 in association with naturally occurring malignant catarrhal fever in captive sika deer (Cervus nippon). J Vet Diagn Invest. 2003;15:179-83 pubmed
    ..A male sika deer that was housed with the hinds and a fawn from 1 of the hinds remained asymptomatic and were PCR negative for CpHV-2. This represents the first report of mortality with MCF-like lesions in association with CpHV-2...
  2. Thiry J, Tempesta M, Camero M, Tarsitano E, Muylkens B, Meurens F, et al. Clinical protection against caprine herpesvirus 1 genital infection by intranasal administration of a live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine. BMC Vet Res. 2007;3:33 pubmed
  3. Borchers K, Wiik H, Frölich K, Ludwig H, East M. Antibodies against equine herpesviruses and equine arteritis virus in Burchell's zebras (Equus burchelli ) from the Serengeti ecosystem. J Wildl Dis. 2005;41:80-6 pubmed
  4. Camero M, Crescenzo G, Marinaro M, Tarsitano E, Bellacicco A, Armenise C, et al. Cidofovir does not prevent caprine herpesvirus type-1 neural latency in goats. Antivir Ther. 2010;15:785-8 pubmed publisher
  5. Gray W. Simian varicella virus: molecular virology. Curr Top Microbiol Immunol. 2010;342:291-308 pubmed publisher
    ..In addition, SVV expressing foreign genes are being investigated as potential recombinant varicella vaccines...
  6. Tempesta M, Camero M, Bellacicco A, Tarsitano E, LoRusso A, Martella V, et al. Caprine herpesvirus 1 vaccine with the LTK63 mutant as a mucosal adjuvant induces strong protection against genital infection in goats. Vaccine. 2007;25:7927-30 pubmed
    ..These findings suggest that mucosal immunization is potentially exploitable in the control of genital infection by herpesviruses...
  7. Mahalingam R, Wellish M, Soike K, White T, Kleinschmidt DeMasters B, Gilden D. Simian varicella virus infects ganglia before rash in experimentally infected monkeys. Virology. 2001;279:339-42 pubmed
    ..Like other organs, monkey ganglia become infected with SVV before the appearance of rash...
  8. Ou Y, Davis K, Traina Dorge V, Gray W. Simian varicella virus expresses a latency-associated transcript that is antisense to open reading frame 61 (ICP0) mRNA in neural ganglia of latently infected monkeys. J Virol. 2007;81:8149-56 pubmed
    ..In this regard, SVV gene expression during latency is similar to that of HSV-1 and other neurotropic animal alphaherpesviruses but differs from that reported for VZV...
  9. Tempesta M, Camero M, Bellacicco A, Tarsitano E, Crescenzo G, Thiry J, et al. Potent inhibition of genital herpesvirus infection in goats by cidofovir. Antivir Ther. 2007;12:977-9 pubmed
    ..Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs...

More Information

Publications84

  1. Schoeb T, Eberle R, Black D, Parker R, Cartner S. Diagnostic exercise: papulovesicular dermatitis in rhesus macaques (Macaca mulatta). Vet Pathol. 2008;45:592-4 pubmed publisher
    ..Simian varicella virus was identified as the cause by polymerase chain reaction analysis and serologic testing...
  2. White T, Mahalingam R, Traina Dorge V, Gilden D. Persistence of simian varicella virus DNA in CD4(+) and CD8(+) blood mononuclear cells for years after intratracheal inoculation of African green monkeys. Virology. 2002;303:192-8 pubmed
  3. Tempesta M, Greco G, Pratelli A, Buonavoglia D, Camero M, Martella V, et al. Reactivation of caprine herpesvirus 1 in experimentally infected goats. Vet Rec. 2002;150:116-7 pubmed
  4. Tempesta M, Crescenzo G, Camero M, Bellacicco A, Tarsitano E, Decaro N, et al. Assessing the efficacy of cidofovir against herpesvirus-induced genital lesions in goats using different therapeutic regimens. Antimicrob Agents Chemother. 2008;52:4064-8 pubmed publisher
    ..Herpesvirus genital infection of goats is a useful animal model to study the activity of antiviral drugs against human herpesvirus infections...
  5. Camero M, Bellacicco A, Tarsitano E, Decaro N, Martella V, Tempesta M, et al. Intravaginal administration of an inactivated vaccine prevents lesions induced by caprine herpesvirus-1 in goats. Vaccine. 2007;25:1658-61 pubmed
    ..Even without adjuvants, prolonged mucosal vaccination induced production of secretory IgA and provided significant clinical protection...
  6. Marinaro M, Bellacicco A, Tarsitano E, Camero M, Colao V, Tempesta M, et al. Detection of Caprine herpesvirus 1-specific antibodies in goat sera using an enzyme-linked immunosorbent assay and serum neutralization test. J Vet Diagn Invest. 2010;22:245-8 pubmed
  7. Verweij M, Lipinska A, Koppers Lalic D, van Leeuwen W, Cohen J, Kinchington P, et al. The capacity of UL49.5 proteins to inhibit TAP is widely distributed among members of the genus Varicellovirus. J Virol. 2011;85:2351-63 pubmed publisher
    ..The varicella-zoster virus and simian varicellovirus UL49...
  8. Marinaro M, Bellacicco A, Camero M, Tarsitano E, Tempesta M, Cassone A, et al. Caprine herpesvirus-1-specific IgG subclasses in naturally and experimentally infected goats. Vet Microbiol. 2009;138:266-72 pubmed publisher
    ..The results are discussed from the standpoint that the profile of the IgG subclasses is instrumental to study immune responses to CpHV-1 and that vaccination strategies may benefit from this information...
  9. Keuser V, Gogev S, Schynts F, Thiry E. Demonstration of generalized infection with caprine herpesvirus 1 diagnosed in an aborted caprine fetus by PCR. Vet Res Commun. 2002;26:221-6 pubmed
  10. Tempesta M, Camero M, Bellacicco A, Thiry J, Crescenzo G, Neyts J, et al. Cidofovir is effective against caprine herpesvirus 1 infection in goats. Antiviral Res. 2007;74:138-41 pubmed
    ..CpHV-1 infection in goats may represent an excellent animal model for the study of novel strategies for the treatment of primary genital HSV-2 infection in man...
  11. van Hall T, Laban S, Koppers Lalic D, Koch J, Precup C, Asmawidjaja P, et al. The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1. J Immunol. 2007;178:657-62 pubmed
    ..In this article, we demonstrate that the varicellovirus protein UL49...
  12. Yanai T, Fujishima N, Fukushi H, Hirata A, Sakai H, Masegi T. Experimental infection of equine herpesvirus 9 in dogs. Vet Pathol. 2003;40:263-7 pubmed
    ..These findings indicate that dogs are fully susceptible to EHV-9 and that EHV-9 can cause fulminant encephalitis with high mortality in dogs, as in gazelles and goats...
  13. Kodama A, Yanai T, Yomemaru K, Sakai H, Masegi T, Yamada S, et al. Acute neuropathogenicity with experimental infection of equine herpesvirus 9 in common marmosets (Callithrix jacchus). J Med Primatol. 2007;36:335-42 pubmed
    ..Equine herpesvirus 9 (EHV-9) is a new neurotropic equine herpesvirus which induced encephalitis in a variety of animals. However, there was no information on the susceptibility of EHV-9 in primates...
  14. Koppers Lalic D, Reits E, Ressing M, Lipinska A, Abele R, Koch J, et al. Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc Natl Acad Sci U S A. 2005;102:5144-9 pubmed
    ..UL49.5 is degraded along with TAP via a reaction that requires the cytoplasmic tail of UL49.5. Thus, UL49.5 represents a unique immune evasion protein that inactivates TAP through a unique two-tiered process...
  15. Kolappaswamy K, Mahalingam R, Traina Dorge V, Shipley S, Gilden D, Kleinschmidt Demasters B, et al. Disseminated simian varicella virus infection in an irradiated rhesus macaque (Macaca mulatta). J Virol. 2007;81:411-5 pubmed
    ..These findings parallel those from humans with disseminated varicella infection and support the usefulness of SVV infection as a model for human varicella-zoster virus infection, particularly virus reactivation after gamma-irradiation...
  16. Thiry J, Tempesta M, Camero M, Tarsitano E, Bellacicco A, Thiry E, et al. A live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine induces a partial cross-protection against caprine herpesvirus 1 infection in goats. Vet Microbiol. 2006;113:303-8 pubmed
    ..These data indicate the safety and the partial efficacy of a live attenuated gE-negative BoHV-1 vaccine intranasally administrated in goats...
  17. Keuser V, Detry B, Thiry J, de Fays K, Schynts F, Pastoret P, et al. Characterization of caprine herpesvirus 1 glycoprotein D gene and its translation product. Virus Res. 2006;115:112-21 pubmed
    ..In spite of the observed differences which could influence its biological functions, CpHV-1 gD shares most characteristics with other alphaherpesviruses and especially BoHV-1...
  18. Tempesta M, Camero M, Sciorsci R, Greco G, Minoia R, Martella V, et al. Experimental infection of goats at different stages of pregnancy with caprine herpesvirus 1. Comp Immunol Microbiol Infect Dis. 2004;27:25-32 pubmed
    ..The results confirm the damaging effect of CpHV.1 infection on pregnancy, the difficulty in diagnosing the CpHV.1 induced abortion, and the importance developing appropriate prophylactic programmes...
  19. Messaoudi I, Barron A, Wellish M, Engelmann F, Legasse A, Planer S, et al. Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans. PLoS Pathog. 2009;5:e1000657 pubmed publisher
    ..Intrabronchial inoculation of rhesus macaques with SVV provides a novel model to analyze viral and immunological mechanisms of VZV latency and reactivation...
  20. Keuser V, Espejo Serrano J, Schynts F, Georgin J, Thiry E. Isolation of caprine herpesvirus type 1 in Spain. Vet Rec. 2004;154:395-9 pubmed
    ..The two Spanish isolates were closely related but could easily be distinguished from each other and from the reference strains...
  21. Ashburn C, Gray W. Expression of the simian varicella virus glycoprotein L and H. Arch Virol. 2002;147:335-48 pubmed
    ..gL and gH transcripts and antigens were detected in tissues of monkeys with acute simian varicella. The simian varicella model offers an opportunity to investigate the role of the gL and gH in viral pathogenesis...
  22. Koppers Lalic D, Verweij M, Lipinska A, Wang Y, Quinten E, Reits E, et al. Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP. PLoS Pathog. 2008;4:e1000080 pubmed publisher
    ..5. Taken together, these results classify the UL 49.5 gene products of BHV-1, PRV, EHV-1, and EHV-4 as members of a novel family of viral immune evasion proteins, inhibiting TAP through a variety of mechanisms...
  23. Gray W. Pathogenesis of simian varicella virus. J Med Virol. 2003;70 Suppl 1:S4-8 pubmed
    ..During or after acute infection, SVV establishes latent infection in the ganglia of surviving monkeys. The virus may reactivate later in life to cause secondary disease and viral transmission to susceptible monkeys...
  24. Marinaro M, Rezza G, Del Giudice G, Colao V, Tarsitano E, Camero M, et al. A caprine herpesvirus 1 vaccine adjuvanted with MF59™ protects against vaginal infection and interferes with the establishment of latency in goats. PLoS ONE. 2012;7:e34913 pubmed publisher
    ..Thus, a vaccine composed of inactivated CpHV-1 plus MF59™ as adjuvant was strongly immunogenic and induced effective immunity against vaginal CpHV-1 infection in goats...
  25. Gray W, Starnes B, White M, Mahalingam R. The DNA sequence of the simian varicella virus genome. Virology. 2001;284:123-30 pubmed
    ..The results of this study confirm the relatedness of SVV and VZV and provide further support for simian varicella as a model to investigate VZV pathogenesis and latency...
  26. Gray W, Davis K, Ou Y, Ashburn C, Ward T. Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Arch Virol. 2007;152:553-63 pubmed
    ..SVV gene 61 is expressed in liver, lung, and neural ganglia of infected monkeys during acute simian varicella...
  27. Uzal F, Woods L, Stillian M, Nordhausen R, Read D, Van Kampen H, et al. Abortion and ulcerative posthitis associated with caprine herpesvirus-1 infection in goats in California. J Vet Diagn Invest. 2004;16:478-84 pubmed
    ..The results presented here support the hypothesis that the male goat is involved in the transmission of CHV-1. However, other forms of transmission cannot be ruled out...
  28. Elia G, Tarsitano E, Camero M, Bellacicco A, Buonavoglia D, Campolo M, et al. Development of a real-time PCR for the detection and quantitation of caprine herpesvirus 1 in goats. J Virol Methods. 2008;148:155-60 pubmed
  29. Meurens F, Keil G, Muylkens B, Gogev S, Schynts F, Negro S, et al. Interspecific recombination between two ruminant alphaherpesviruses, bovine herpesviruses 1 and 5. J Virol. 2004;78:9828-36 pubmed
  30. Gray W. Simian varicella: a model for human varicella-zoster virus infections. Rev Med Virol. 2004;14:363-81 pubmed
  31. Tempesta M, Greco G, Tarsitano E, Thiry J, Camero M, Decaro N, et al. Analysis of antibody response in goats to caprine herpesvirus 1. Biologicals. 2005;33:283-7 pubmed
    ..The neutralizing antibody titers and the pattern of antibody reactivity were hypothesized to modulate the reactivation and re-excretion process of CpHV.1. ..
  32. Jääskeläinen A, Moilanen K, Bühler S, Lappalainen M, Vapalahti O, Vaheri A, et al. Serological microarray for detection of HSV-1, HSV-2, VZV, and CMV antibodies. J Virol Methods. 2009;160:167-71 pubmed publisher
    ..The serological microarray showed potential for screening purposes. The microarray based analyses were easy to perform, and HSV-1, HSV-2, VZV, and CMV antibodies could be detected on the same microarray...
  33. Mahalingam R, Traina Dorge V, Wellish M, Lorino R, Sanford R, Ribka E, et al. Simian varicella virus reactivation in cynomolgus monkeys. Virology. 2007;368:50-9 pubmed
    ..Virus reactivation was confirmed not only by the occurrence of zoster in one monkey, but also by the presence of late SVV RNA in ganglia, and the detection of SVV DNA in non-ganglionic tissue, and SVV antigens in skin, ganglia and lung. ..
  34. Pumphrey C, Gray W. Identification and analysis of the simian varicella virus thymidine kinase gene. Arch Virol. 1996;141:43-55 pubmed
    ..Identification of the SVV TK ORF will facilitate studies that examine the role of viral TKs in pathogenesis and antiviral sensitivity and provides a potential insertion site for the expression of foreign genes...
  35. Mahalingam R, Gray W. The simian varicella virus genome contains an invertible 665 base pair terminal element that is absent in the varicella zoster virus genome. Virology. 2007;366:387-93 pubmed
    ..The terminal region is transcriptionally active and is also present in the genomes of other animal varicelloviruses but absent in the VZV genome. ..
  36. Li A, Lu G, Qi J, Wu L, Tian K, Luo T, et al. Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D. PLoS Pathog. 2017;13:e1006314 pubmed publisher
    ..In the current study, we systematically studied the characteristics of nectin-1 binding by the gD of a Varicellovirus genus member, the pseudorabies virus (PRV)...
  37. Wilkes R, Ward D, Newkirk K, Adams J, Kania S. Evaluation of delivery agents used for introduction of small interfering RNAs into feline corneal cells. Am J Vet Res. 2013;74:243-7 pubmed publisher
    ..The tested anti-FHV-1-specific siRNAs could potentially be used as a treatment for FHV-1 if a successful means of in vivo delivery can be achieved. ..
  38. Piper K, Fitzgerald C, Ficorilli N, Studdert M. Isolation of caprine herpesvirus 1 from a major outbreak of infectious pustular vulvovaginitis in goats. Aust Vet J. 2008;86:136-8 pubmed publisher
    ..This is the first report of CpHV infectious pustular vulvovaginitis in goats in Victoria and to our knowledge appears to be one of the largest outbreaks recorded anywhere. ..
  39. Brunner C, Kanellos T, Meli M, Sutton D, Gisler R, Gomes Keller M, et al. Antibody induction after combined application of an adjuvanted recombinant FeLV vaccine and a multivalent modified live virus vaccine with a chlamydial component. Vaccine. 2006;24:1838-46 pubmed
    ..felis but diminished for FPV. The use of these vaccines in combination was safe and will simplify vaccination schedules in veterinary practice. ..
  40. Thiry J, Saegerman C, Chartier C, Mercier P, Keuser V, Thiry E. Serological evidence of caprine herpesvirus 1 infection in Mediterranean France. Vet Microbiol. 2008;128:261-8 pubmed
    ..Moreover, the difference observed between Corse-du-Sud and Dordogne and Vendée suggests that CpHV-1 is more prevalent in Mediterranean countries or regions than in central and northern Europe. ..
  41. Doucette K, Dor F, Wilkinson R, Martin S, Huang C, Cooper D, et al. Gene expression of porcine lymphotrophic herpesvirus-1 in miniature Swine with posttransplant lymphoproliferative disorder. Transplantation. 2007;83:87-90 pubmed
    ..This model provides insights into the pathogenesis of PTLD and, by extension, potential diagnostic and therapeutic tools for human EBV-associated PTLD. ..
  42. Wong D, Belgrave R, Williams K, Del Piero F, Alcott C, Bolin S, et al. Multinodular pulmonary fibrosis in five horses. J Am Vet Med Assoc. 2008;232:898-905 pubmed publisher
    ..Equine herpesvirus type 5 is found in association with EMPF; although the exact pathogenic role this virus plays in EMPF is unknown, equine herpesvirus type 5 may be an etiologic agent or cofactor in the development of EMPF. ..
  43. Pugazhenthi S, Gilden D, Nair S, McAdoo A, Wellish M, Brazeau E, et al. Simian varicella virus induces apoptosis in monkey kidney cells by the intrinsic pathway and involves downregulation of bcl-2 expression. J Virol. 2009;83:9273-82 pubmed publisher
    ..Together, these findings indicate that SVV induces apoptosis in cultured Vero cells through the intrinsic pathway in which Bcl-2 is downregulated. ..
  44. Sun Y, Conner J. Characterization of heterosubunit complexes formed by the R1 and R2 subunits of herpes simplex virus 1 and equine herpes virus 4 ribonucleotide reductase. Biochem J. 2000;347 Pt 1:97-104 pubmed
    ..Therefore probably neither of these amino acids has a direct role in catalysis. However, mutation of the highly conserved Tyr-1111 to Phe in HSV-1 R1 inactivated enzyme activity without affecting subunit interaction. ..
  45. Dawson S, Willoughby K, Gaskell R, Wood G, Chalmers W. A field trial to assess the effect of vaccination against feline herpesvirus, feline calicivirus and feline panleucopenia virus in 6-week-old kittens. J Feline Med Surg. 2001;3:17-22 pubmed
    ..There was no difference between the conventionally and early-vaccinated groups in terms of antibody response to any antigen by 12 and 15 weeks of age...
  46. El Habashi N, Murakami M, El Nahass E, Hibi D, Sakai H, Fukushi H, et al. Study on the infectivity of equine herpesvirus 9 (EHV-9) by different routes of inoculation in hamsters. Vet Pathol. 2011;48:558-64 pubmed publisher
    ..These results suggest that in the animals infected by the oral, ocular, and peritoneal routes, EHV-9 might travel to the brain through nerves, other than by the olfactory route, after initial propagation at the site of viral entry. ..
  47. Wild P, Schraner E, Peter J, Loepfe E, Engels M. Novel entry pathway of bovine herpesvirus 1 and 5. J Virol. 1998;72:9561-6 pubmed
    ..There is strong evidence that the intact virus particle is then transported to the nuclear region...
  48. Andrew S. Ocular manifestations of feline herpesvirus. J Feline Med Surg. 2001;3:9-16 pubmed
    ..Diagnostic techniques discussed include: virus isolation, fluorescent antibody testing, serum neutralising titers, ELISA and polymerase chain reaction. Various therapies are also discussed...
  49. Damiani A, Matsumura T, Yokoyama N, Maeda K, Miyazawa T, Kai C, et al. Nucleotide sequences of glycoprotein I and E genes of equine herpesvirus type 4. J Vet Med Sci. 1998;60:219-25 pubmed
    ..These sequence data will be useful for development of a modified live vaccine against equine herpesvirus type 1 and 4 infections. ..
  50. Pesavento P, Liu H, Ossiboff R, Stucker K, Heymer A, Millon L, et al. Characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses. J Virol Methods. 2009;157:105-10 pubmed publisher
    ..These cells will be useful for studies of feline viral disease and for in vitro studies of feline epithelia. ..
  51. Loch S, Klauschies F, Scholz C, Verweij M, Wiertz E, Koch J, et al. Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion. J Biol Chem. 2008;283:13428-36 pubmed publisher
    ..5. Within this new immune evasion mechanism, we show for the first time that additive elements of a small viral factor and their signaling across the ER membrane are essential for targeted degradation of a multi-subunit membrane complex. ..
  52. Yanai T, Tujioka S, Sakai H, Fukushi H, Hirai K, Masegi T. Experimental infection with equine herpesvirus 9 (EHV-9) in cats. J Comp Pathol. 2003;128:113-8 pubmed
    ..These findings indicate that the cat, like certain other species such as the goat, is susceptible to experimental infection with EHV-9, and may be at risk from natural infection...
  53. Minamoto T, Honjo M, Uchii K, Yamanaka H, Suzuki A, Kohmatsu Y, et al. Detection of cyprinid herpesvirus 3 DNA in river water during and after an outbreak. Vet Microbiol. 2009;135:261-6 pubmed publisher
    ..The sequences of CyHV-3 collected from the Yura River matched perfectly with that of the CyHV-3 Japanese strain, suggesting that they share the same origin...
  54. Maggs D, Clarke H. Relative sensitivity of polymerase chain reaction assays used for detection of feline herpesvirus type 1 DNA in clinical samples and commercial vaccines. Am J Vet Res. 2005;66:1550-5 pubmed
    ..To determine relative detection rates and detection limits for 6 published polymerase chain reaction (PCR) assays used for detection of feline herpesvirus type 1 (FHV-1) DNA...
  55. El Habashi N, El Nahass E, Fukushi H, Hibi D, Sakai H, Sasseville V, et al. Experimental intranasal infection of equine herpesvirus 9 (EHV-9) in suckling hamsters: kinetics of viral transmission and inflammation in the nasal cavity and brain. J Neurovirol. 2010;16:242-8 pubmed publisher
    ..These results indicate that EHV-9 rapidly invades the brain via the olfactory route after experimental intranasal infection...
  56. Nelli R, Maes R, Kiupel M, Hussey G. Use of a feline respiratory epithelial cell culture system grown at the air-liquid interface to characterize the innate immune response following feline herpesvirus 1 infection. Virus Res. 2016;214:39-48 pubmed publisher
    ..The data presented show the development of a system ideal for investigating the molecular pathogenesis and immunity of FHV-1 or other respiratory pathogens. ..
  57. Williams K, Maes R, del Piero F, Lim A, Wise A, Bolin D, et al. Equine multinodular pulmonary fibrosis: a newly recognized herpesvirus-associated fibrotic lung disease. Vet Pathol. 2007;44:849-62 pubmed
    ..Further, we propose that this newly described disease develops in association with infection by the equine gamma-herpesvirus, EHV-5...
  58. McCoy M, Montgomery D, Bratanich A, Cavender J, Scharko P, Vickers M. Serologic and reproductive findings after a herpesvirus-1 abortion storm in goats. J Am Vet Med Assoc. 2007;231:1236-9 pubmed
    ..An abortion storm occurred in a goat herd, resulting in 75 aborted kids and 1 neonatal death from December 2004 to February 2005...
  59. Pumphrey C, Gray W. DNA sequence and transcriptional analysis of the simian varicella virus glycoprotein B gene. J Gen Virol. 1994;75 ( Pt 11):3219-27 pubmed
    ..The SVV and VZV gB promoter elements are similar in content and align closely. The VZV gB transcript start site suggests a gB polypeptide initiation site which is inconsistent with the previously reported ATG start codon...
  60. das Neves C, Mørk T, Godfroid J, Sørensen K, Breines E, Hareide E, et al. Experimental infection of reindeer with cervid herpesvirus 2. Clin Vaccine Immunol. 2009;16:1758-65 pubmed publisher
    ..We conclude that CvHV2 can cause systemic infection, that both genital and respiratory inoculations can lead to virus shedding, and that the virus can infect the fetus in utero...
  61. Ou Y, Gray W. Simian varicella virus gene 28 and 29 promoters share a common upstream stimulatory factor-binding site and are induced by IE62 transactivation. J Gen Virol. 2006;87:1501-8 pubmed
    ..The findings demonstrate similarities between SVV and VZV ORF 28/29 expression and indicate that the simian varicella model may be useful to investigate the differential regulation of viral genes during lytic and latent infection...
  62. Wong W, Kelman M, Ward M. Surveillance of upper respiratory tract disease in owned cats in Australia, 2009-2012. Prev Vet Med. 2013;112:150-5 pubmed publisher
    ..The distributions of cases reported in this surveillance system provide information to aid the diagnosis of infectious feline URTD and to develop client educational programs...
  63. Leon A, Fortier G, Fortier C, Freymuth F, Tapprest J, Leclercq R, et al. Detection of equine herpesviruses in aborted foetuses by consensus PCR. Vet Microbiol. 2008;126:20-9 pubmed
  64. Borchers K, Wolfinger U, Ludwig H. Latency-associated transcripts of equine herpesvirus type 4 in trigeminal ganglia of naturally infected horses. J Gen Virol. 1999;80 ( Pt 8):2165-71 pubmed
    ..Overall, these studies clearly demonstrate that EHV-4 is latent in trigeminal ganglia...
  65. Hukkanen R, Gillen M, Grant R, Liggitt H, Kiem H, Kelley S. Simian varicella virus in pigtailed macaques (Macaca nemestrina): clinical, pathologic, and virologic features. Comp Med. 2009;59:482-7 pubmed
    ..The described cases occurred in animals with reconstituted immune systems (after total-body irradiation) and demonstrate the clinical effects of infection with an endemic infectious agent in animals with a questionable immune status...
  66. Haberthur K, Kraft A, Arnold N, Park B, Meyer C, Asquith M, et al. Genome-wide analysis of T cell responses during acute and latent simian varicella virus infections in rhesus macaques. J Virol. 2013;87:11751-61 pubmed publisher
    ..Given the close genome relatedness of SVV and VZV, our studies highlight immunogenic ORFs that may be further investigated as potential components of novel VZV vaccines that specifically boost T cell immunity. ..
  67. Borchers K, Wolfinger U, Lawrenz B, Schellenbach A, Ludwig H. Equine herpesvirus 4 DNA in trigeminal ganglia of naturally infected horses detected by direct in situ PCR. J Gen Virol. 1997;78 ( Pt 5):1109-14 pubmed
    ..This report formally proves that, like other members of the Alpha-herpesvirinae, EHV-4 establishes latency in the trigeminal ganglia...
  68. Ward T, Williams M, Traina Dorge V, Gray W. The simian varicella virus uracil DNA glycosylase and dUTPase genes are expressed in vivo, but are non-essential for replication in cell culture. Virus Res. 2009;142:78-84 pubmed publisher
    ..Further studies will evaluate the pathogenesis of SVV dUTPase and UDG mutants and their potential as varicella vaccines...
  69. Johnson M, Martin M, Stone B, Hetzel U, Kipar A. Survival of a cat with pneumonia due to cowpox virus and feline herpesvirus infection. J Small Anim Pract. 2009;50:498-502 pubmed publisher
    ..The present report describes the case of a cat that recovered from a pneumonia in which both poxvirus and feline herpesvirus were demonstrated...
  70. Wilkes R, Kania S. Use of interfering RNAs targeted against feline herpesvirus 1 glycoprotein D for inhibition of feline herpesvirus 1 infection of feline kidney cells. Am J Vet Res. 2009;70:1018-25 pubmed publisher
    ..To evaluate the use of RNA interference targeted against feline herpesvirus 1 (FHV-1) glycoprotein D for inhibition of FHV-1 infection of feline kidney cells...
  71. Schrenzel M, Tucker T, Donovan T, Busch M, Wise A, Maes R, et al. New hosts for equine herpesvirus 9. Emerg Infect Dis. 2008;14:1616-9 pubmed publisher
    ..The virus was also found in an aborted Persian onager. Thus, the natural host range is extended to 6 species in 3 mammalian orders...
  72. Trapp S, Beer M, Mettenleiter T. [Biology of bovine herpesviruses]. Berl Munch Tierarztl Wochenschr. 2003;116:171-8 pubmed
    ..The related BHV-5 is an exotic neurovirulent agent and like BHV-1 a member of the genus Varicellovirus, within the subfamily Alphaherpesvirinae...
  73. Field H, Biswas S, Mohammad I. Herpesvirus latency and therapy--from a veterinary perspective. Antiviral Res. 2006;71:127-33 pubmed
    ..The review briefly focuses on herpes infections in the horse and cat where some progress has already been achieved in the veterinary antiviral field...
  74. van Maanen C, de Boer Luijtze E, Terpstra C. Development and validation of a monoclonal antibody blocking ELISA for the detection of antibodies against both equine herpesvirus type 1 (EHV1) and equine herpesvirus type 4 (EHV4). Vet Microbiol. 2000;71:37-51 pubmed
    ..We concluded that the Mab blocking ELISA is more sensitive, easier to perform, more rapid and more reproducible than the VN test. We consider this test as a valuable tool for serological diagnosis of both EHV1 and EHV4 infections...
  75. Pagnini U, Montagnaro S, Sanfelice di Monteforte E, Pacelli F, De Martino L, Roperto S, et al. Caprine herpesvirus-1 (CapHV-1) induces apoptosis in goat peripheral blood mononuclear cells. Vet Immunol Immunopathol. 2005;103:283-93 pubmed
    ..However, penetration of virus particles and infection was not required for PCD, as UV-inactivated CapHV-1 induced apoptosis of mitogen-stimulated bovine peripheral blood mononuclear cells in vitro...