cercopithecine herpesvirus 1

Summary

Summary: A species of SIMPLEXVIRUS that causes vesicular lesions of the mouth in monkeys. When the virus is transmitted to man it causes an acute encephalitis or encephalomyelitis, which is nearly always fatal.

Top Publications

  1. Huff J, Eberle R, Capitanio J, Zhou S, Barry P. Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques. J Gen Virol. 2003;84:83-92 pubmed
    ..Detection of B virus DNA shedding is a relatively rare event associated with the breeding season, while RhCMV DNA is persistently detected in mucosal fluids of most monkeys...
  2. Huff J, Barry P. B-virus (Cercopithecine herpesvirus 1) infection in humans and macaques: potential for zoonotic disease. Emerg Infect Dis. 2003;9:246-50 pubmed
    ..b>Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (..
  3. Perelygina L, Zhu L, Zurkuhlen H, Mills R, Borodovsky M, Hilliard J. Complete sequence and comparative analysis of the genome of herpes B virus (Cercopithecine herpesvirus 1) from a rhesus monkey. J Virol. 2003;77:6167-77 pubmed
    The complete DNA sequence of herpes B virus (Cercopithecine herpesvirus 1) strain E2490, isolated from a rhesus macaque, was determined. The total genome length is 156,789 bp, with 74...
  4. Cohen J, Davenport D, Stewart J, Deitchman S, Hilliard J, Chapman L. Recommendations for prevention of and therapy for exposure to B virus (cercopithecine herpesvirus 1). Clin Infect Dis. 2002;35:1191-203 pubmed
    B virus (Cercopithecine herpesvirus 1) is a zoonotic agent that can cause fatal encephalomyelitis in humans. The virus naturally infects macaque monkeys, resulting in disease that is similar to herpes simplex virus infection in humans...
  5. Ostrowski S, Leslie M, Parrott T, Abelt S, Piercy P. B-virus from pet macaque monkeys: an emerging threat in the United States?. Emerg Infect Dis. 1998;4:117-21 pubmed
    ..A common observation was that children were more than three times as likely to be bitten than adults. The virus must be assumed to be a potential health hazard in macaque bite wounds; this risk makes macaques unsuitable as pets...
  6. Smith A, Black D, Eberle R. Molecular evidence for distinct genotypes of monkey B virus (herpesvirus simiae) which are related to the macaque host species. J Virol. 1998;72:9224-32 pubmed
  7. Engel G, Jones Engel L, Schillaci M, Suaryana K, Putra A, Fuentes A, et al. Human exposure to herpesvirus B-seropositive macaques, Bali, Indonesia. Emerg Infect Dis. 2002;8:789-95 pubmed
    Herpesvirus B (Cercopithecine herpesvirus 1) has been implicated as the cause of approximately 40 cases of meningoencephalitis affecting persons in direct or indirect contact with laboratory macaques...
  8. Lee F, Lin Y, Deng M, Lee T, Huang C. Prevalence of antibody reaction with cercopithecine herpesvirus 1 antigen in Macaca cyclopis, Macaca fascicularis, and Papio anubis in Taiwan. J Med Primatol. 2007;36:343-7 pubmed
    ..sera were collected between December 2004 and September 2005 and tested by a commercially available dot immunobinding assay for the antibodies to cercopithecine herpesvirus 1, an alphaherpesvirus with high mortality for infected humans.
  9. Elmore D, Eberle R. Monkey B virus (Cercopithecine herpesvirus 1). Comp Med. 2008;58:11-21 pubmed
    ..B virus (Cercopithecine herpesvirus 1; BV) is an alpha-herpesvirus that naturally infects conventional populations of macaques...

More Information

Publications77

  1. Ohsawa K, Black D, Sato H, Eberle R. Sequence and genetic arrangement of the U(S) region of the monkey B virus (cercopithecine herpesvirus 1) genome and comparison with the U(S) regions of other primate herpesviruses. J Virol. 2002;76:1516-20 pubmed
    ..These results demonstrate that the BV U(S) region is entirely colinear with that of HSV type 1 (HSV-1), HSV-2, and simian agent 8 virus...
  2. Huemer H, Wechselberger C, Bennett A, Falke D, Harrington L. Cloning and expression of the complement receptor glycoprotein C from Herpesvirus simiae (herpes B virus): protection from complement-mediated cell lysis. J Gen Virol. 2003;84:1091-100 pubmed
    ..This, together with the heparin-sensitivity of the gC(SHBV)-C3 interaction on the infected cell surface, suggests a role in adherence to heparan sulphate, similar to the gC proteins of other herpesviruses. ..
  3. Sanabria Solano C, Gonzalez C, Richerioux N, Bertrand L, Dridi S, Griffiths A, et al. Regulation of viral gene expression by the herpes simplex virus 1UL24 protein (HSV-1UL24 inhibits accumulation of viral transcripts). Virology. 2016;495:148-60 pubmed publisher
    ..These results reveal a new role for HSV-1UL24 in regulating viral mRNA accumulation. ..
  4. Tanaka S, Mannen K, Sato H. Use of herpesvirus papio 2 as an alternative antigen in immunoblotting assay for B virus diagnosis. J Vet Med Sci. 2004;66:529-32 pubmed
    ..No specific bands could be detected with BV-negative sera. These results show the usefulness of HVP2 antigen as an alternative and safer antigen than authentic BV antigen in detecting BV antibody in immunoblotting. ..
  5. Gray W, Gusick N. Viral isolates derived from simian varicella epizootics are genetically related but are distinct from other primate herpesviruses. Virology. 1996;224:161-6 pubmed
    ..In addition, REn profiles of SVV isolates, derived from primary and secondary episodes of simian varicella in the same monkey, were identical, providing evidence for SVV reactivation in a latently infected monkey. ..
  6. Fujima A, Ochiai Y, Saito A, Omori Y, Noda A, Kazuyama Y, et al. Discrimination of antibody to herpes B virus from antibody to herpes simplex virus types 1 and 2 in human and macaque sera. J Clin Microbiol. 2008;46:56-61 pubmed
    ..It is suggested that the ELISA with the recombinant antigens is useful not only for the serodiagnosis of primate herpesvirus infections but also for elucidation of the seroprevalence of herpesviruses in humans and primates. ..
  7. Yang F, Zhang H, Zhang Y, Chen W, Yuan H, Lin H. A hepatitis B virus inhibitory neolignan from Herpetospermum caudigerum. Chem Pharm Bull (Tokyo). 2010;58:402-4 pubmed
    ..The new compound exhibited inhibitory effects against hepatitis B virus. ..
  8. Gerber S, Hohlfeld P. Screening for infectious diseases. Childs Nerv Syst. 2003;19:429-32 pubmed
    ..Maternal serologic tests must be performed to look for an infectious etiology; the most frequent agents are the components of the TORCH complex. But additional serology must include parvovirus B19, HIV, and coxsackieviruses. ..
  9. Wolfensohn S, Gopal R. Interpretation of serological test results for simian herpes B virus. Lab Anim. 2001;35:315-20 pubmed
    ..In June 1999 one animal was found to be unexpectedly BV positive (non-negative). The investigation of this result highlights some of the issues and difficulties that may be encountered in such a programme. ..
  10. Ritchey J, Payton M, Eberle R. Clinicopathological characterization of monkey B virus (Cercopithecine herpesvirus 1) infection in mice. J Comp Pathol. 2005;132:202-17 pubmed
    ..Viral antigen was detected immunohistochemically in the lesions. The results indicated an ascending encephalomyelitis syndrome similar to that produced by BV in man. ..
  11. Coulibaly C, Hack R, Seidl J, Chudy M, Itter G, Plesker R. A natural asymptomatic herpes B virus infection in a colony of laboratory brown capuchin monkeys (Cebus apella). Lab Anim. 2004;38:432-8 pubmed
    ..All may act as a source of BV infection in humans, hence routine, repeated testing of all primates is essential. ..
  12. Ritchey J, Ealey K, Payton M, Eberle R. Comparative pathology of infections with baboon and African green monkey alpha-herpesviruses in mice. J Comp Pathol. 2002;127:150-61 pubmed
    ..This murine model may prove useful in the investigation of viral or host determinants responsible for the varying neurovirulence of these simian alpha-herpesviruses. ..
  13. Kuller L, Watanabe R, Anderson D, Grant R. Development of a whole-virus multiplex flow cytometric assay for antibody screening of a specific pathogen-free primate colony. Diagn Microbiol Infect Dis. 2005;53:185-93 pubmed
    ..The multiplexed assay provided greater sensitivity, increased stability, and better performance than ELISA...
  14. Lu Y, Aguirre A, Hamm C, Wang Y, Yu Q, Loh P, et al. Establishment, cryopreservation, and growth of 11 cell lines prepared from a juvenile Hawaiian monk seal, Monachus schauinslandi. Methods Cell Sci. 2000;22:115-24 pubmed
    ..These newly established cell lines are currently being used for the investigation of an eye disease occurring in captive monk seal pups in Oahu and will be available for future isolation and study of monk seal viruses. ..
  15. Morton W, Agy M, Capuano S, Grant R. Specific pathogen-free macaques: definition, history, and current production. ILAR J. 2008;49:137-44 pubmed
    ..SRV), simian immunodeficiency virus (SIV), simian T cell lymphotropic/leukemia virus (STLV), and Cercopithecine herpesvirus 1 (CHV-1)...
  16. Focher F, Lossani A, Verri A, Spadari S, Maioli A, Gambino J, et al. Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrob Agents Chemother. 2007;51:2028-34 pubmed
    ..Our studies characterize BV TK for the first time and suggest new lead compounds, e.g., 5-ethyldeoxyuridine and pencyclovir, which may be superior to ACV or GCV as treatment for this emerging infectious disease. ..
  17. Gray W, Gusick N, Ek Kommonen C, Kempson S, Fletcher T. The inverted repeat regions of the simian varicella virus and varicella-zoster virus genomes have a similar genetic organization. Virus Res. 1995;39:181-93 pubmed
    ..Comparison with the VZV RS indicates the SVV and VZV RS regions are similar in size and genetic organization...
  18. Black D, Saliki J, Eberle R. Development of a green fluorescent protein reporter cell line to reduce biohazards associated with detection of infectious Cercopithecine herpesvirus 1 (monkey B virus) in clinical specimens. Comp Med. 2002;52:534-42 pubmed
    ..Performing virus isolation on samples suspected of containing Cercopithecine herpesvirus 1 (monkey B virus [BV]) is dangerous due to the extreme neuropathogenicity of this virus in humans, and ..
  19. Black D, Maxwell L, Eberle R. Characterization of a spontaneous drug-resistant mutant of monkey B virus (Macacine herpesvirus 1). Arch Virol. 2009;154:1495-7 pubmed publisher
    ..These results demonstrate that spontaneous drug-resistant mutants of BV do occur and that the BV TK is responsible for sensitivity to PCV. ..
  20. Sariol C, Gonzalez Martinez J, Arana T, Gascot S, Suarez E, Maldonado E, et al. Differential distribution of antibodies to different viruses in young animals in the free-ranging rhesus macaques of Cayo Santiago. J Med Primatol. 2006;35:369-75 pubmed
    ..The seroprevalence to cercopithecine herpesvirus type 1 (B virus) and simian retroviruses has been studied previously...
  21. Ooi L, Ho W, Ngai K, Tian L, Chan P, Sun S, et al. Narcissus tazetta lectin shows strong inhibitory effects against respiratory syncytial virus, influenza A (H1N1, H3N2, H5N1) and B viruses. J Biosci. 2010;35:95-103 pubmed
    ..NTL with a high selective index (SI=CC50/IC50 > or = 141) resulting from its potent antiviral activity and low cytotoxicity demonstrates a potential for biotechnological development as an antiviral agent...
  22. Ritz N, Curtis N, Buttery J, Babl F. Monkey bites in travelers: should we think of herpes B virus?. Pediatr Emerg Care. 2009;25:529-31 pubmed publisher
    ..The risk in travelers remains unknown. We report a case of a 7-year-old girl bitten by a macaque on her forehead and discuss her postexposure management...
  23. Ohsawa K, Black D, Sato H, Rogers K, Eberle R. Sequence and genetic arrangement of the UL region of the monkey B virus (Cercopithecine herpesvirus 1) genome and comparison with the UL region of other primate herpesviruses. Arch Virol. 2003;148:989-97 pubmed
    ..The BV genes are arranged in the same order and orientation as in HSV. These results demonstrate that the BV U(L) region is entirely co-linear with that of HSV-1 and HSV-2...
  24. Oya C, Ochiai Y, Taniuchi Y, Takano T, Ueda F, Yoshikawa Y, et al. Specific detection and identification of herpes B virus by a PCR-microplate hybridization assay. J Clin Microbiol. 2004;42:1869-74 pubmed
    ..The utility of the PCR-microplate hybridization assay for genetic detection and identification of the polymorphic region of herpes B virus was determined...
  25. Perelygina L, Patrusheva I, Zurkuhlen H, Hilliard J. Characterization of B virus glycoprotein antibodies induced by DNA immunization. Arch Virol. 2002;147:2057-73 pubmed
    Genes encoding glycoproteins gB, gC, gD, gE, and gG of herpes B virus (species Cercopithecine herpesvirus 1) were cloned into mammalian expression vector pcDNA3.1/V5-His...
  26. Gray W, Mullis L, Soike K. Viral gene expression during acute simian varicella virus infection. J Gen Virol. 2002;83:841-6 pubmed
    ..The study provides a foundation for further investigation on the role of viral genes in varicella pathogenesis and latency...
  27. Lupi O, Tyring S. Tropical dermatology: viral tropical diseases. J Am Acad Dermatol. 2003;49:979-1000; quiz 1000-2 pubmed
    ..Dermatologic lesions occur in all these diseases and can facilitate a rapid diagnosis, leading to control of the virus and helping prevent possible outbreaks...
  28. Takano J, Narita T, Fujimoto K, Mukai R, Yamada A. Detection of B virus infection in cynomolgus monkeys by ELISA using simian agent 8 as alternative antigen. Exp Anim. 2001;50:345-7 pubmed
    ..The present data indicates that detection of BV antibody can be achieved accurately and safely by enzyme-linked immunosorbent assay (ELISA) using SA8 antigen...
  29. Pumphrey C, Gray W. DNA sequence of the simian varicella virus (SVV) gH gene and analysis of the SVV and varicella zoster virus gH transcripts. Virus Res. 1995;38:55-70 pubmed
    ..The extensive conservation of SVV and VZV genes and predicted polypeptides further supports the use of SVV infection of non-human primates as a model of VZV infection of humans...
  30. Tanabayashi K, Mukai R, Yamada A. Detection of B virus antibody in monkey sera using glycoprotein D expressed in mammalian cells. J Clin Microbiol. 2001;39:3025-30 pubmed
    The gene encoding glycoprotein D (gD) of the monkey B virus (Cercopithecine herpesvirus 1) was cloned into a mammalian expression vector, pcDNA3.1(-), and the recombinant plasmid DNA was transfected into COS7 cells...
  31. Gautier J. [Ketosis-prone type 2 diabetes mellitus in sub-Saharan Africans: possible contribution of human herpes virus 8 infection]. Med Sci (Paris). 2008;24:665-6 pubmed publisher
  32. Oya C, Ochiai Y, Taniuchi Y, Takano T, Fujima A, Ueda F, et al. Prevalence of herpes B virus genome in the trigeminal ganglia of seropositive cynomolgus macaques. Lab Anim. 2008;42:99-103 pubmed publisher
    ..We found that the virus DNA was present in one or both TG of 12 of the 30 macaques (40%) tested, with the virus being detected from both TG in five of the 12 macaques and from a single TG in the remaining seven...
  33. Duval B, Deceuninck G. Seroprotection rates after late doses of hepatitis B vaccine. Pediatrics. 2002;109:350-1 pubmed
  34. Mitsunaga F, Nakamura S, Hayashi T, Eberle R. Changes in the titer of anti-B virus antibody in captive macaques (Macaca fuscata, M. mulatta, M. fascicularis). Comp Med. 2007;57:120-4 pubmed
    Changes in levels of antibody to B virus (Cercopithecine herpesvirus 1; BV) were examined in BV-positive macaques by ELISA...
  35. Iwasaki T, Hatagishi E. [Cercopithecine herpesvirus 1 (CeHV-1)]. Nihon Rinsho. 2006;64 Suppl 3:290-5 pubmed
  36. Pumphrey C, Gray W. Identification and analysis of the simian varicella virus thymidine kinase gene. Arch Virol. 1996;141:43-55 pubmed
    ..Identification of the SVV TK ORF will facilitate studies that examine the role of viral TKs in pathogenesis and antiviral sensitivity and provides a potential insertion site for the expression of foreign genes...
  37. Yates J, Camiolo S, Ali S, Ying A. Comparison of the EBNA1 proteins of Epstein-Barr virus and herpesvirus papio in sequence and function. Virology. 1996;222:1-13 pubmed
    ..The results showed that changes within EBNA1 can differentially alter its transcriptional and replicational activities...
  38. Mothana R, Mentel R, Reiss C, Lindequist U. Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra. Phytother Res. 2006;20:298-302 pubmed
    ..7 to 12.5 microg/mL. In addition, 17 plants of the 25 investigated exhibited anti-HSV-1 activity. The antiviral activity of some active extracts was also observed on a molecular level...
  39. Jarrett R. Viruses and lymphoma/leukaemia. J Pathol. 2006;208:176-86 pubmed
    ..Recent data suggest that hepatitis C virus infection is also associated with an increased incidence of lymphoma, whereas data relating to SV40 remain controversial...
  40. Hilliard J, Griffin W. Comment on viral tropical diseases. J Am Acad Dermatol. 2004;51:1038-9 pubmed
  41. Miranda M, Handermann M, Darai G. DNA polymerase gene locus of Cercopithecine herpesvirus 1 is a suitable target for specific and rapid identification of viral infection by PCR technology. Virus Genes. 2005;30:307-22 pubmed
    ..Numerous human and animal pathogenic herpesviruses have been identified so far, including Cercopithecine herpesvirus 1 (CeHV-1)...
  42. Hirano M, Nakamura S, Mitsunaga F, Okada M, Shimizu K, Ueda M, et al. Efficacy of a B virus gD DNA vaccine for induction of humoral and cellular immune responses in Japanese macaques. Vaccine. 2002;20:2523-32 pubmed
    ..Thus, the BV gD DNA vaccine was demonstrated to induce both humoral and cellular immune responses in macaques which recognized BV gD...
  43. Jensen K, Alvarado Ramy F, Gonzalez Martinez J, Kraiselburd E, Rullán J. B-virus and free-ranging macaques, Puerto Rico. Emerg Infect Dis. 2004;10:494-6 pubmed
    ..This incident underscores the importance of education about risks associated with interactions between humans and nonhuman primates...
  44. Hayashi K, Ohara N, Teramoto N, Onoda S, Chen H, Oka T, et al. An animal model for human EBV-associated hemophagocytic syndrome: herpesvirus papio frequently induces fatal lymphoproliferative disorders with hemophagocytic syndrome in rabbits. Am J Pathol. 2001;158:1533-42 pubmed
    ..These data indicate that the high rate of rabbit LPD with HPS induction is caused by HVP. This system is useful for studying the pathogenesis, prevention, and treatment of human EBV-AHS...
  45. Sariol C, Arana T, Maldonado E, Gerald M, Gonzalez Martinez J, Rodriguez M, et al. Herpes B-virus seroreactivity in a colony of Macaca mulatta: data from the Sabana Seca Field Station, a new specific pathogen-free program. J Med Primatol. 2005;34:13-9 pubmed
    ..6% of animals recruited to this SPF program showed serovariability to B-virus over the initial 2 years of examination. Implications for all SPF programs are discussed in this article...
  46. Perelygina L, Patrusheva I, Hombaiah S, Zurkuhlen H, Wildes M, Patrushev N, et al. Production of herpes B virus recombinant glycoproteins and evaluation of their diagnostic potential. J Clin Microbiol. 2005;43:620-8 pubmed
    B virus (cercopithecine herpesvirus 1) is the only deadly alphaherpesvirus that is zoonotically transmissible from macaques to humans...
  47. Scharf B, Wan C, Bluth M, Eberle R, Videan E, Smith E, et al. Lethargy, ulcers, bronchopneumonia and death in two aged female bonnet macaques presumed to be caused by Cercopithicine herpes virus I. J Med Primatol. 2008;37 Suppl 1:60-4 pubmed publisher
    ..The emergence of fatal B virus to primates in this pen may have been associated with the combination of age and stress in the affected individuals...
  48. Yoshikawa Y. [B virus disease]. Nihon Rinsho. 2007;65 Suppl 3:131-4 pubmed
  49. Ritchey J, Black D, Rogers K, Eberle R. In vivo experimentation with simian herpesviruses: assessment of biosafety and molecular contamination. J Am Assoc Lab Anim Sci. 2006;45:7-12 pubmed
    ..In addition, viral DNA can contaminate a microtome knife such that subsequently sectioned uninoculated control tissues exhibit false positive PCR amplification...
  50. Andersen E. B virus--the risks in monkey business. AAOHN J. 2005;53:385-7 pubmed
  51. Ward J, Hilliard J. Herpes B virus-specific pathogen-free breeding colonies of macaques: serologic test results and the B-virus status of the macaque. Contemp Top Lab Anim Sci. 2002;41:36-41 pubmed
    ..Patterns of seroreactivity are more useful in identifying B virus-positive macaques during the screening phase of SPF colony development than during the maintenance phase...
  52. Krug P, Schinazi R, Hilliard J. Inhibition of B virus (Macacine herpesvirus 1) by conventional and experimental antiviral compounds. Antimicrob Agents Chemother. 2010;54:452-9 pubmed publisher
    ..Further, the considerably higher potency of FEAU (2'-fluoro-5-ethyl-Ara-U) than of conventional antiviral drugs argues for its compassionate use in advanced human B virus infections...
  53. White T, Mahalingam R, Traina Dorge V, Gilden D. Simian varicella virus DNA is present and transcribed months after experimental infection of adult African green monkeys. J Neurovirol. 2002;8:191-203 pubmed
    ..Overall, intratracheal inoculation of SVV in African green monkeys resulted in the presence of viral DNA and transcription of multiple viral genes in many tissues for months after experimental infection...
  54. Perelygina L, Zurkuhlen H, Patrusheva I, Hilliard J. Identification of a herpes B virus-specific glycoprotein d immunodominant epitope recognized by natural and foreign hosts. J Infect Dis. 2002;186:453-61 pubmed
    The mapping of linear epitopes of B virus (Cercopithecine herpesvirus 1 and herpes B virus) glycoprotein D (gD) was accomplished by screening the constructed gD epitope library with serum from B virus-infected macaques...
  55. Blewett E, Saliki J, Eberle R. Development of a competitive ELISA for detection of primates infected with monkey B virus (Herpesvirus simiae). J Virol Methods. 1999;77:59-67 pubmed
    ..ELISAs (C-ELISAs) are described that allow detection of antibodies against monkey B virus (BV, Cercopithecine herpesvirus 1). The assays utilize monoclonal antibodies (MABs) directed against the BV glycoprotein B (gB)...
  56. Yamamoto H, Ohsawa K, Walz S, Mitchen J, Watanabe Y, Eberle R, et al. Validation of an enzyme-linked immunosorbent assay kit using herpesvirus papio 2 (HVP2) antigen for detection of herpesvirus simiae (B virus) infection in rhesus monkeys. Comp Med. 2005;55:244-8 pubmed
    ..The high degree of correlation (weighted kappa coefficient, 0.94) between the two tests indicates that the HVP2 ELISA is a sensitive and reliable assay for in-house testing of the BV status of rhesus monkeys...
  57. Abbott A. French university under fire for culling macaques. Nature. 2008;455:145 pubmed publisher
  58. Schillaci M, Jones Engel L, Engel G, Paramastri Y, Iskandar E, Wilson B, et al. Prevalence of enzootic simian viruses among urban performance monkeys in Indonesia. Trop Med Int Health. 2005;10:1305-14 pubmed
    ..Antibodies to simian retrovirus were detected in 10.5% of the macaques. Antibodies to Cercopithecine Herpesvirus 1, were detected in 5.3% of the macaques...
  59. Titti F, Zamarchi R, Maggiorella M, Sernicola L, Geraci A, Negri D, et al. Infection of simian B lymphoblastoid cells with simian immunodeficiency virus is associated with upregulation of CD23 and CD40 cell surface markers. J Med Virol. 2002;68:129-40 pubmed
    ..These findings support the hypothesis that SIV induce phenotypic perturbations in B cells that might eventually contribute to the development of lymphoproliferative disease...
  60. Westmoreland S, Mansfield K. Comparative pathobiology of Kaposi sarcoma-associated herpesvirus and related primate rhadinoviruses. Comp Med. 2008;58:31-42 pubmed
    ..This review examines the comparative pathobiology of KSHV, discusses the role of macaque rhadinoviruses as models of human disease, and outlines the derivation of specific pathogen-free animals...
  61. Ohsawa K, Black D, Torii R, Sato H, Eberle R. Detection of a unique genotype of monkey B virus (Cercopithecine herpesvirus 1) indigenous to native Japanese macaques (Macaca fuscata). Comp Med. 2002;52:555-9 pubmed
    ..It has long been assumed that the monkey population was not infected with Cercopithecine herpesvirus 1 (monkey B virus [BV]) since cases of human BV infection have never been reported in Japan...
  62. Greenwood A. Herpesvirus B in macaque monkeys. Vet Rec. 2002;151:516 pubmed
  63. Besecker M, Harden M, Li G, Wang X, Griffiths A. Discovery of herpes B virus-encoded microRNAs. J Virol. 2009;83:3413-6 pubmed publisher
    ..We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs...
  64. Johns B, Gudmundsson K, Turner E, Allen S, Samano V, Ray J, et al. Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents. Bioorg Med Chem. 2005;13:2397-411 pubmed
    ..The antiviral data suggests that non-polar amines are preferred for optimal activity. Additionally, the 2' position has been shown to require an NH group to retain activity levels similar to that of the gold standard acyclovir...
  65. Shao W, Li X. [Construction of recombinant eukaryotic expression plasmid of murine chemokine MIP-1alpha and coimmunization with HSV-II DNA vaccine]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006;22:286-9 pubmed
  66. Andrade M, Yee J, Barry P, Spinner A, Roberts J, Cabello P, et al. Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil. Am J Primatol. 2003;59:123-8 pubmed
    ..All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group...
  67. Hondo R, Saito A, Ueda F. [Infectious disease of simian herpes B virus]. Nihon Rinsho. 2005;63:2189-95 pubmed
    ..These results would be able to become important and fundamental knowledge for the sero-epidemiological analysis of the infectious stile...
  68. Mahalingam R, Traina Dorge V, Wellish M, Smith J, Gilden D. Naturally acquired simian varicella virus infection in African green monkeys. J Virol. 2002;76:8548-50 pubmed
    ..This animal model provides an experimental system to gain information about varicella latency with direct relevance to the human disease...