bovine herpesvirus 2

Summary

Summary: A species of SIMPLEXVIRUS causing mammillitis in cattle in Great Britain and South Africa.

Top Publications

  1. De Giuli L, Magnino S, Vigo P, Labalestra I, Fabbi M. Development of a polymerase chain reaction and restriction typing assay for the diagnosis of bovine herpesvirus 1, bovine herpesvirus 2, and bovine herpesvirus 4 infections. J Vet Diagn Invest. 2002;14:353-6 pubmed
    ..fragment length polymorphism) was developed for the simultaneous detection of bovine herpesvirus 1, bovine herpesvirus 2, and bovine herpesvirus 4 infections...
  2. Jelic I, May J. The UL24 consensus regions of bovine herpesvirus 2 isolate 554 and clinical isolates of herpes simplex viruses 1 and 2. J Gen Appl Microbiol. 2003;49:363-6 pubmed
  3. Cargnelutti J, Weiblen R, Flores E. A multiplex PCR for viruses associated with exanthematic and vesicular disease in cattle. J Virol Methods. 2017;239:38-41 pubmed publisher
    ..Elsewhere, Bovine herpesvirus 2 (BoHV-2) has also been associated with similar clinical signs...
  4. Chase C, Lohff C, Letchworth G. Resistance and susceptibility of bovine cells expressing herpesviral glycoprotein D homologs to herpesviral infections. Virology. 1993;194:365-9 pubmed
    ..herpesvirus 1 glycoprotein IV (gIV) were susceptible to infection with three other bovine herpesviruses: bovine herpesvirus 2, bovine herpesvirus 4 (BHV-4) and alcelaphine herpesvirus 1...
  5. Sheppard M, May J. Location and characterization of the bovine herpesvirus type 2 thymidine kinase gene. J Gen Virol. 1989;70 ( Pt 11):3067-71 pubmed
    ..Despite there being only limited overall sequence homology with the TK genes of other herpesviruses, there are several regions of extensive homology at the amino acid level...
  6. Rebordosa X, Pinol J, Perez Pons J, Lloberas J, Naval J, Serra Hartmann X, et al. Glycoprotein E of bovine herpesvirus type 1 is involved in virus transmission by direct cell-to-cell spread. Virus Res. 1996;45:59-68 pubmed
  7. Torres F, Cargnelutti J, Masuda E, Weiblen R, Flores E. Acute and latent infection by bovine herpesvirus type 2 in a guinea pig model. Microb Pathog. 2010;48:69-73 pubmed publisher
    ..herpetic mammillits is a self-limiting cutaneous disease of the udder and teats of cows associated with bovine herpesvirus 2 (BoHV-2) whose pathogenesis is poorly understood...
  8. Kálmán D, Egyed L. PCR detection of bovine herpesviruses from nonbovine ruminants in Hungary. J Wildl Dis. 2005;41:482-8 pubmed
    ..BoHV-4 was detected in all species, with prevalence ranging from 12% to 69%. Sequenced PCR products were 99-100% identical to bovine herpesviral sequences deposited in the GenBank...
  9. May J. Comparison of six Australian isolates of Bovine herpes virus 2 based on UL24 gene after a passage in MDBK cells. Acta Virol. 2002;46:175-8 pubmed
    A region of the UL24 gene of six Australian field isolates of Bovine herpesvirus 2 (BHV-2) was sequenced after a passage in Madin-Darby bovine kidney (MDBK) cells by polymerase chain reaction (PCR)...

More Information

Publications46

  1. Bhat M, Manickam R, Kumanan K. Serological evidence of bovine herpesviruses 1 and 2 in Asian elephants. J Wildl Dis. 1997;33:919-20 pubmed
    ..Twenty-five (23%) of the 109 elephant sera had PHA titers ranging from 1:8 to 1:64 against BHV 2. Asian elephants appear to be better reservoirs for herpesviruses which are serologically related to BHV 2...
  2. Skinner G, Cowan M, Davies J, Brookes K, Billstrom M, Buchan A. Reduced tumorigenicity of rodent tumour cells and tumour explants following infection with wild type and mutant herpes simplex virus, bovine mammillitis virus and encephalomyocarditis virus. Br J Exp Pathol. 1988;69:495-504 pubmed
    ..It is suggested that the therapeutic role of wild type, mutant or recombinant viruses merits further exploration towards prevention and treatment of human cancer...
  3. Yeung K, d Offay J, Oakes J. Genomic location of bovid herpesvirus type 2 nucleotide sequences homologous to five herpes simplex virus type 1 genes. Virus Res. 1988;10:369-80 pubmed
    ..24 and 0.27 m.u. In addition, BHV-2 nucleotide sequences homologous to HSV-1 genes for TK, gB and gD were found to lie on both sides of restriction endonuclease cleavage sites at 0.30, 0.35, and 0.94 m.u., respectively...
  4. Manning A, Buchan A, Skinner G, Durham J, Thompson H. The immunological relationship between canine herpesvirus and four other herpesviruses. J Gen Virol. 1988;69 ( Pt 7):1601-8 pubmed
    ..The data suggest that CHV is immunologically more closely related to herpes simplex virus than to the other viruses used in this study...
  5. Skinner G, Buchan A, Davies J, Durham J, Castrucci G. A virus-particle vaccine prepared from bovine mammillitis virus against herpes genitalis. Comp Immunol Microbiol Infect Dis. 1991;14:133-50 pubmed
    ..The immunogenicity and protective efficacy of this vaccine in human subjects will be investigated in a double-blind placebo-controlled trial...
  6. Castrucci G, Ferrari M, Frigeri F, Aldrovandi V. A further study on relationships between herpes simplex virus and Bovid herpesvirus-2. Microbiologica. 1990;13:101-7 pubmed
    ..It was speculated that the possibility of HSV replicating in cattle must still be considered an open question...
  7. Borchers K, Brackmann J, Wolf O, Rudolph M, Glatzel P, Krasinska M, et al. Virologic investigations of free-living European bison (Bison bonasus) from the Bialowieza Primeval Forest, Poland. J Wildl Dis. 2002;38:533-8 pubmed
    ..None of the bison had significant antibody titers against BoHV-1, bovine herpesvirus 2, BoHV-4, caprine herpesvirus 1, cervid herpesvirus 1, or bovine viral diarrhea (BVD) virus-1...
  8. Onodera K, d Offay J, Melcher U. Nylon membrane-immobilized PCR for detection of bovine viruses. Biotechniques. 2002;32:74-6, 78, 80 pubmed
    ..When amplification was assayed by chemiluminescent detection of incorporated DIG-nucleotides, the expected amplification patterns were obtained...
  9. Ehlers B, Goltz M, Ejercito M, Dasika G, Letchworth G. Bovine herpesvirus type 2 is closely related to the primate alphaherpesviruses. Virus Genes. 1999;19:197-203 pubmed
    ..Thus one can speculate that BoHV-2 may represent a greater hazard to humans than has been appreciated previously...
  10. Pietschmann S, Gelderblom H, Pauli G. Compartment-specific immunolocalization of conserved epitopes of the glycoprotein gB of herpes simplex virus type 1 and bovine herpes virus type 2 in infected cells. Arch Virol. 1989;108:1-17 pubmed
    ..This unexpected result is interpreted in terms of two hypotheses: (1) presence of common epitopes on two entirely different herpesvirus proteins conserved in HSV-1 and BHV-2 and (2) transport of gB or its precursor into the nucleus...
  11. d Offay J, Floyd J, Eberle R, Saliki J, Brock K, D Andrea G, et al. Use of a polymerase chain reaction assay to detect bovine herpesvirus type 2 DNA in skin lesions from cattle suspected to have pseudo-lumpy skin disease. J Am Vet Med Assoc. 2003;222:1404-7, 1366-7 pubmed
    ..Our findings suggest that PLSD may be more common and widespread in the United States than suggested by the frequency with which BHV-2 has been isolated from cattle with PLSD-like skin lesions...
  12. Sharma S, Singh K. Ischaemic necrosis of the teat base in cattle and buffaloes. Vet Rec. 2006;158:32 pubmed
  13. Bushnell S, Edwards S. The development and standardization of an enzyme-linked immunosorbent assay for the detection of antibodies to bovine herpesvirus 2. J Biol Stand. 1988;16:45-53 pubmed
    A single dilution enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to bovine herpesvirus 2 has been developed, standardized and compared with the virus neutralization test...
  14. Blum S, Mazuz M, Brenner J, Friedgut O, Stram Y, Koren O, et al. Sample-based assessment of the microbial etiology of bovine necrotic vulvovaginitis. Theriogenology. 2007;68:290-3 pubmed
    ..Thus the results of this study substantiate the essential role of P. levii in the etiology of BNVV and indicate that BHV4 is not required as a predisposing factor to the syndrome...
  15. Torres F, Almeida S, Silva M, Weiblen R, Flores E. Distribution of latent bovine herpesvirus 2 DNA in tissues of experimentally infected sheep. Res Vet Sci. 2009;87:161-6 pubmed publisher
    The biology of latent infection by bovine herpesvirus 2 (BoHV-2), the agent of mammillitis in cows, remains largely unknown...
  16. May J, Awad M, Reum A, Sheppard M. Bovine herpes mammalitis virus thymidine kinase gene. Acta Virol. 1990;34:188-92 pubmed
    ..2-0.32. This particular DNA fragment can transfect LTk-mouse cells and convert them to Tk+. The gene position of BHMV Tk would suggest another homologous gene map position for BHMV and herpes simplex virus (HSV)...
  17. Metzler A, Ossent P, Guscetti F, Rubel A, Lang E. Serological evidence of herpesvirus infection in captive Asian elephants (Elephas maximus). J Wildl Dis. 1990;26:41-9 pubmed
    ..evaluate contact animals and elephants from a second herd for antibody to bovine herpesvirus 1 (BHV1) and bovine herpesvirus 2 (BHV2). Of 15 sera tested four displayed low neutralizing antibody titers to BHV2...
  18. Spilki F, Esteves P, da Silva A, Franco A, Rijsewijk F, Roehe P. A monoclonal antibody-based ELISA allows discrimination between responses induced by bovine herpesvirus subtypes 1 (BoHV-1.1) and 2 (BoHV-1.2). J Virol Methods. 2005;129:191-3 pubmed
    ..1-immunized calves (kappa = 0.799). The test may be useful to provide new insights into the roles played by each of these two subtypes in the epidemiology of BoHV-1 infections...
  19. Imai K, Ishihara R, Nishimori T. First demonstration of bovine herpesvirus 2 infection among cattle by neutralization test in Japan. J Vet Med Sci. 2005;67:317-20 pubmed
    Seroepidemiological surveys were performed on neutralizing antibody to bovine herpesvirus 2 (BoHV-2) among cattle in Japan. A total of 1,819 sera were collected from cattle in 27 prefectures from 1997 to 1998...
  20. Geiger R, Munz E, Hübschle O, Reimann M. [Seroepizootiologic studies of the distribution of bovine herpesvirus type 1 and 2 (BHV 1, BHV 2) in Namibia]. Zentralbl Veterinarmed B. 1990;37:197-202 pubmed
    ..In the commercial farming area with best farming conditions the percentage was lowest, but it was south of here again higher in the areas of lower precipitation where farming conditions are less optimal...
  21. Conraths F, Pauli G, Ludwig H. Monoclonal antibodies directed against a 130K glycoprotein of bovine herpesvirus 2 cross-react with glycoprotein B of herpes simplex virus. Virus Res. 1988;10:53-63 pubmed
    ..Some of them are involved in the neutralization of HSV and BHV-2...
  22. Castrucci G, Frigeri F, Cilli V, Rampichini L, Ranuçi S, Poli G, et al. A study of bovid herpesvirus 2 infection in calves inoculated intradermally or intranasally. Comp Immunol Microbiol Infect Dis. 1979;1:277-83 pubmed
    ..These findings suggest that the skin and the nervous system play an important role in the naturally-occurring disease since they could be the sites where the virus is maintained latently in the host...
  23. Flores E, Osorio F, Zanella E, Kit S, Kit M. Efficacy of a deletion mutant bovine herpesvirus-1 (BHV-1) vaccine that allows serologic differentiation of vaccinated from naturally infected animals. J Vet Diagn Invest. 1993;5:534-40 pubmed
    ..The use of the IBRV(NG)dltkdlgIII strain in conjunction with an anti-gIII specific blocking ELISA kit represents a powerful tool for BHV-1 control/eradication programs...
  24. Thiry E, Vercouter M, Dubuisson J, Barrat J, Sepulchre C, Gerardy C, et al. Serological survey of herpesvirus infections in wild ruminants of France and Belgium. J Wildl Dis. 1988;24:268-73 pubmed
    ..1 (BHV-1), bovid herpesvirus 6 (BHV-6), herpesvirus of Cervidae type 1 (HVC-1), reindeer herpesvirus, bovine herpesvirus 2 (BHV-2) and bovid herpesvirus 4 (BHV-4) was investigated in wild ruminants of France and Belgium between ..
  25. Adams S, Balachandran N, Hutt Fletcher L. Proteins specified by bovine herpesvirus-2. Am J Vet Res. 1988;49:443-8 pubmed
    ..Host cell protein synthesis was not reduced substantially until postinfection hours 22 to 28...
  26. Janett F, Stäuber N, Schraner E, Stocker H, Thun R. [Bovine herpes mammillitis: clinical symptoms and serologic course]. Schweiz Arch Tierheilkd. 2000;142:375-80 pubmed
    ..The relatively low BHV-2 SNT-titres as well as the seasonal increase of BHV-2 titres and seroprevalence in the month of September were indicative of a chronic and latent BHV-2 infection in the herd...
  27. Dubuisson J, Thiry E, Bublot M, Sneyers M, Boulanger D, Guillaume J, et al. Production and characterization of monoclonal antibodies to bovid herpesvirus-4. Vet Microbiol. 1989;19:305-15 pubmed
    ..One of the Mabs also reacted against AHV-1, indicating an antigenic relationship between BHV-4 and AHV-1. None of the Mabs reacting with BHV-4 possessed neutralizing activity against the strain used for immunization...
  28. Petrovski K. An acute outbreak of teat lesions affecting 38% of a dairy herd in Northland. N Z Vet J. 2005;53:162-3 pubmed
  29. Puliti M, Cenci E, Vecchiarelli A, Blasi E, Merletti L. Systemic infection with Herpes bovis virus 2 evokes a biphasic immune response in the mouse. New Microbiol. 1994;17:281-9 pubmed
    ..In conclusion, our experimental model discloses some immunological aspects underlying the complex host-virus interaction...
  30. Maragos C, May J. Modification of the genital herpes infection in a guinea pig model, by prior immunization with bovine herpes mammillitis virus. Microbiol Immunol. 1988;32:547-50 pubmed
    ..Bovine herpes mammillitis virus has been shown to partially protect guinea pigs against primary genital herpes simplex virus type 2 infections, further confirming the immunologic cross-reactivity of these two viruses...
  31. Kemp R, Holliman A, Nettleton P. Atypical bovine herpes mammillitis affecting cows and calves. Vet Rec. 2008;163:119-21 pubmed
  32. Hammerschmidt W, Conraths F, Mankertz J, Buhk H, Pauli G, Ludwig H. Common epitopes of glycoprotein B map within the major DNA-binding proteins of bovine herpesvirus type 2 (BHV-2) and herpes simplex virus type 1 (HSV-1). Virology. 1988;165:406-18 pubmed
    b>Bovine herpesvirus 2 (BHV-2) specifies a glycoprotein of 130 kDa (gB BHV-2) which shows extensive homology to glycoprotein B (gB-1) of herpes simplex virus 1 (HSV-1)...
  33. Brenner J, Perl S, Lahav D, Garazi S, Oved Z, Shlosberg A, et al. An unusual outbreak of malignant catarrhal fever in a beef herd in Israel. J Vet Med B Infect Dis Vet Public Health. 2002;49:304-7 pubmed
    ..The fact that sheep and goats were housed in close proximity on the same farm reinforced this diagnosis...
  34. Imai K, Ishihara R, Jayawardane G, Nishimori K, Nishimori T. Development of a shuttle polymerase chain reaction for the detection of bovine herpesvirus 2. J Vet Med Sci. 2002;64:953-6 pubmed
    Three different polymerase chain reaction (PCR) protocols were evaluated for their ability to detect bovine herpesvirus 2 (BoHV-2): single-step PCR with 3 reaction stages (denaturation, annealing and extension), 2 reaction stages (..
  35. Gaut R, May J. Loss of thymidine kinase activity due to a base deletion in a candidate vaccine strain of bovine herpesvirus 2. Acta Virol. 1997;41:93-5 pubmed
    ..of the thymidine kinase (TK) gene (a 918 nt long coding region) of two TK-deficient (TK) strains of bovine herpesvirus 2 (BHV-2) was determined...
  36. Smee D, Leonhardt J. Vaccination against bovine herpes mammillitis virus infections in guinea pigs. Intervirology. 1994;37:20-4 pubmed
    ..The vaccinated animals showed dramatically reduced lesion severity and low recoverable virus titers compared to age-matched nonvaccinated animals.(ABSTRACT TRUNCATED AT 250 WORDS)..
  37. Hammerschmidt W, Conraths F, Mankertz J, Pauli G, Ludwig H, Buhk H. Conservation of a gene cluster including glycoprotein B in bovine herpesvirus type 2 (BHV-2) and herpes simplex virus type 1 (HSV-1). Virology. 1988;165:388-405 pubmed
    ..All three genes map in the unique long region of the genome. Their homology and the colinear arrangement compared to HSV-1 indicate a close relationship between the two viruses...