herpesviridae

Summary

Summary: A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.

Top Publications

  1. Eide K, Miller Morgan T, Heidel J, Bildfell R, Jin L. Results of total DNA measurement in koi tissue by Koi Herpes Virus real-time PCR. J Virol Methods. 2011;172:81-4 pubmed publisher
    ..2005). Although one of the unique features of Herpesviridae, the sister family of Herpesvirales, is latent infection, it has not been demonstrated consistently that KHV ..
  2. Segarra A, Pépin J, Arzul I, Morga B, Faury N, Renault T. Detection and description of a particular Ostreid herpesvirus 1 genotype associated with massive mortality outbreaks of Pacific oysters, Crassostrea gigas, in France in 2008. Virus Res. 2010;153:92-9 pubmed publisher
    ..The analyses of 76 sequences showed OsHV-1 microVar detection only in 2008 isolates. These data suggest that OsHV-1 microVar can be assumed as an emergent genotype...
  3. Bergmann S, Sadowski J, Kiełpiński M, Bartłomiejczyk M, Fichtner D, Riebe R, et al. Susceptibility of koi x crucian carp and koi x goldfish hybrids to koi herpesvirus (KHV) and the development of KHV disease (KHVD). J Fish Dis. 2010;33:267-72 pubmed publisher
    ..The present study showed severe losses after a waterborne KHV infection of between 35% and 100% in koi x goldfish and koi x crucian carp hybrids as well as in SPF carp...
  4. Davison A. Herpesvirus systematics. Vet Microbiol. 2010;143:52-69 pubmed publisher
    ..The former family Herpesviridae was elevated to a new order, the Herpesvirales, which now accommodates 3 families, 3 subfamilies, 17 genera ..
  5. Dong C, Li X, Weng S, Xie S, He J. Emergence of fatal European genotype CyHV-3/KHV in mainland China. Vet Microbiol. 2013;162:239-44 pubmed publisher
    ..In summary, we are the first to confirm the emergence of fatal European genotype CyHV-3/KHV in East and Southeast Asia. Our study will provide new insight to explore the virus origin and epidemiology, as well as its pathogenicity...
  6. Rose N, Warren A, Whiteside D, Bidulka J, Robinson J, Illanes O, et al. Columbid herpesvirus-1 mortality in great horned owls (Bubo virginianus) from Calgary, Alberta. Can Vet J. 2012;53:265-8 pubmed
    ..The sequence of a PCR amplicon had 99.7% homology to Columbid herpesvirus-1...
  7. Paludan S, Bowie A, Horan K, Fitzgerald K. Recognition of herpesviruses by the innate immune system. Nat Rev Immunol. 2011;11:143-54 pubmed publisher
  8. van Beurden S, Bossers A, Voorbergen Laarman M, Haenen O, Peters S, Abma Henkens M, et al. Complete genome sequence and taxonomic position of anguillid herpesvirus 1. J Gen Virol. 2010;91:880-7 pubmed publisher
    ..Our analyses support a recent proposal to subdivide the family Alloherpesviridae into two sister clades, one containing AngHV1 and the cyprinid herpesviruses and the other containing Ictalurid herpesvirus 1 and the ranid herpesviruses...
  9. Hertel L. Herpesviruses and intermediate filaments: close encounters with the third type. Viruses. 2011;3:1015-40 pubmed publisher
    ..These interactions, either known or potential, will be the focus of this review...

More Information

Publications74

  1. Sawada A, Koyama Sato M, Yasui M, Kondo O, Ishihara T, Takeshita Y, et al. Multiplex polymerase chain reaction for six herpesviruses after hematopoietic stem cell transplantation. Pediatr Int. 2011;53:1010-7 pubmed publisher
  2. Zachariah A, Zong J, Long S, Latimer E, Heaggans S, RICHMAN L, et al. Fatal herpesvirus hemorrhagic disease in wild and orphan asian elephants in southern India. J Wildl Dis. 2013;49:381-93 pubmed publisher
    ..Instead, both the virus and the disease are evidently widespread in Asia and, despite the disease severity, Asian elephants appear to be the ancient endogenous hosts of both EEHV1A and EEHV1B...
  3. Jakob N, Kehm R, Gelderblom H. A novel fish herpesvirus of Osmerus eperlanus. Virus Genes. 2010;41:81-5 pubmed publisher
    ..All attempts to study host range of HVOE1 failed as no virus replication was observed, indicating that infectivity was lost or the suitable cell culture was missing. The genomic DNA of HVOE1 was analyzed by DNA restriction endonucleases...
  4. Connolly S, Jackson J, Jardetzky T, Longnecker R. Fusing structure and function: a structural view of the herpesvirus entry machinery. Nat Rev Microbiol. 2011;9:369-81 pubmed publisher
  5. Soto S, Gonzalez B, Willoughby K, Maley M, Olvera A, Kennedy S, et al. Systemic herpesvirus and morbillivirus co-infection in a striped dolphin (Stenella coeruleoalba). J Comp Pathol. 2012;146:269-73 pubmed publisher
    ..To our knowledge, this is the first report of a cetacean co-infected by dolphin morbillivirus and herpesvirus with evidence of lesions attributable to both viruses...
  6. Michou V, Liarmakopoulou S, Thomas D, Tsimaratou K, Makarounis K, Constantoulakis P, et al. Herpes virus infected spermatozoa following density gradient centrifugation for IVF purposes. Andrologia. 2012;44:174-80 pubmed publisher
    ..Further studies are required to determine whether any correlation exists between their presence, implantation rate and the outcome of pregnancy...
  7. Tai S, Niikura M, Cheng H, Kruger J, Wise A, Maes R. Complete genomic sequence and an infectious BAC clone of feline herpesvirus-1 (FHV-1). Virology. 2010;401:215-27 pubmed publisher
    ..The virus regenerated from the BAC was very similar to the parental C-27 strain in vitro in terms of plaque morphology and growth characteristics and highly virulent in cats in a preliminary in vivo study...
  8. Luppi M, Luiz A, Coelho F, Malta M, Preis I, Ecco R, et al. Identification and isolation of psittacid herpesvirus from psittacids in Brazil. Vet Microbiol. 2011;154:69-77 pubmed publisher
    ..Thus, a total of 41 isolates were obtained from PsHV cell cultivation in CEF, confirming the circulation of the virus between parrots kept in captivity in Belo Horizonte, and affirming the importance of further studies in this area...
  9. Zou Q, Sun K, Cheng A, Wang M, Xu C, Zhu D, et al. Detection of anatid herpesvirus 1 gC gene by TaqMan fluorescent quantitative real-time PCR with specific primers and probe. Virol J. 2010;7:37 pubmed publisher
    ..1-gC DNA vaccine in infected ducks by TaqMan fluorescent quantitative real-time PCR assay (FQ-PCR) with pcDNA3.1-gC plasmid...
  10. Li R, Zhu J, Xie Z, Liao G, Liu J, Chen M, et al. Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication. Cell Host Microbe. 2011;10:390-400 pubmed publisher
    ..Identification of key cellular targets of the conserved herpesvirus kinases will facilitate the development of broadly effective antiviral strategies...
  11. Siakallis G, Spandidos D, Sourvinos G. Herpesviridae and novel inhibitors. Antivir Ther. 2009;14:1051-64 pubmed publisher
    b>Herpesviridae comprises a large family of double-stranded DNA viruses that infect both animals and humans...
  12. Lee C, Chen M. Escape of herpesviruses from the nucleus. Rev Med Virol. 2010;20:214-30 pubmed publisher
  13. El Matbouli M, Soliman H. Transmission of Cyprinid herpesvirus-3 (CyHV-3) from goldfish to naïve common carp by cohabitation. Res Vet Sci. 2011;90:536-9 pubmed publisher
    ..The results of this study demonstrate that goldfish is a carrier for CyHV-3, permit virus propagation, and disseminate the virus to susceptible carp causing the disease...
  14. Sunarto A, McColl K, Crane M, Sumiati T, Hyatt A, Barnes A, et al. Isolation and characterization of koi herpesvirus (KHV) from Indonesia: identification of a new genetic lineage. J Fish Dis. 2011;34:87-101 pubmed publisher
    ..The I(++)II(-) genotype has not been reported previously and appears to represent a new intermediate lineage that may have emerged in Indonesia...
  15. Phalen D, Holz P, Rasmussen L, Bayley C. Fatal columbid herpesvirus-1 infections in three species of Australian birds of prey. Aust Vet J. 2011;89:193-6 pubmed publisher
    ..These findings increase the number of known species of birds of prey that are susceptible to CoHV-1 infection and indicate that rock pigeons (Columbia livia) should not be included in the diet of captive Australian birds of prey...
  16. Cherezova L, Burnside K, Rose T. Conservation of complex nuclear localization signals utilizing classical and non-classical nuclear import pathways in LANA homologs of KSHV and RFHV. PLoS ONE. 2011;6:e18920 pubmed publisher
  17. Roberts K, Baines J. Actin in herpesvirus infection. Viruses. 2011;3:336-46 pubmed publisher
    ..The goal of this review is to explore these processes and to highlight potential future directions for this area of research...
  18. Lisco A, Munawwar A, Introini A, Vanpouille C, Saba E, Feng X, et al. Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network. J Infect Dis. 2012;205:97-105 pubmed publisher
    ..However, semen is not just a mere passive transporter of virions but also plays an active role in HIV-1 transmission through cytokines and other biological factors...
  19. Michel B, Fournier G, Lieffrig F, Costes B, Vanderplasschen A. Cyprinid herpesvirus 3. Emerg Infect Dis. 2010;16:1835-43 pubmed publisher
    ..nonreplicative). Recent advances with regard to CyHV-3 provide a role for this virus in fundamental and applied research...
  20. Burrows S, Moss D, Khanna R. Understanding human T-cell-mediated immunoregulation through herpesviruses. Immunol Cell Biol. 2011;89:352-8 pubmed publisher
    ..It is highly likely that these newly emerging T-cell-based therapeutic and diagnostic technologies will revolutionize the clinical management of patients with herpesvirus-associated diseases. ..
  21. Bellière E, Esperón F, Arbelo M, Muñoz M, Fernandez A, Sanchez Vizcaino J. Presence of herpesvirus in striped dolphins stranded during the cetacean morbillivirus epizootic along the Mediterranean Spanish coast in 2007. Arch Virol. 2010;155:1307-11 pubmed publisher
    ..No HV lesions were found in any of the coinfected dolphins, which may indicate that HV did not contribute to the mortality in the CeMV outbreak. This is the first report of HV infection in any cetacean from the Mediterranean Sea...
  22. Eide K, Miller Morgan T, Heidel J, Kent M, Bildfell R, LaPatra S, et al. Investigation of koi herpesvirus latency in koi. J Virol. 2011;85:4954-62 pubmed publisher
    ..One of the unique features of Herpesviridae is latent infection following a primary infection. However, KHV latency has not been recognized...
  23. Van den Broeke C, Favoreel H. Actin' up: herpesvirus interactions with Rho GTPase signaling. Viruses. 2011;3:278-92 pubmed publisher
    ..The current review gives an overview of both general and individual interactions of herpesviruses with Rho GTPase signaling...
  24. Franciotta D, Bestetti A, Sala S, Perucca P, Jarius S, Price R, et al. Broad screening for human herpesviridae DNA in multiple sclerosis cerebrospinal fluid and serum. Acta Neurol Belg. 2009;109:277-82 pubmed
    Members of the human herpesviridae family are candidates for representing the macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis...
  25. Lu L, Cheng A, Wang M, Jiang J, Zhu D, Jia R, et al. Polyclonal antibody against the DPV UL46M protein can be a diagnostic candidate. Virol J. 2010;7:83 pubmed publisher
    ..Subsequently, we established Dot-ELISA using the polyclonal antibody and applied it to DPV detection...
  26. Shlapobersky M, Sinyakov M, Katzenellenbogen M, Sarid R, Don J, Avtalion R. Viral encephalitis of tilapia larvae: primary characterization of a novel herpes-like virus. Virology. 2010;399:239-47 pubmed publisher
    ..Phylogenetic analysis, albeit limited, confirms this assumption and places TLEV within the family of Herpesviridae and distantly from the families Alloherpesviridae and Iridoviridae...
  27. Rakus K, Irnazarow I, Adamek M, Palmeira L, Kawana Y, Hirono I, et al. Gene expression analysis of common carp (Cyprinus carpio L.) lines during Cyprinid herpesvirus 3 infection yields insights into differential immune responses. Dev Comp Immunol. 2012;37:65-76 pubmed publisher
    ..It is also demonstrated that the outcome of this severe disease in large extent could be controlled by genetic factors of the host...
  28. Zhao Y, Wang J. Characterization of duck enteritis virus US6, US7 and US8 gene. Intervirology. 2010;53:141-5 pubmed publisher
    Duck enteritis virus (DEV) is a member of the family Herpesviridae, the genome of which is not completely analyzed...
  29. Xin H, Cheng A, Wang M, Jia R, Shen C, Chang H. Identification and characterization of a duck enteritis virus US3-like gene. Avian Dis. 2009;53:363-9 pubmed
    ..In short, the DEV US3-like gene and its in vivo protein expression were found for the first time, and DEV classification and the gene's functions were suggested...
  30. Epperson M, Lee C, Fremont D. Subversion of cytokine networks by virally encoded decoy receptors. Immunol Rev. 2012;250:199-215 pubmed publisher
    ..Structural and mechanistic studies of these decoy receptors have provided a wealth of information, not only about viral pathogenesis but also about the inner workings of cytokine signaling networks...
  31. Taylor M, Koyuncu O, Enquist L. Subversion of the actin cytoskeleton during viral infection. Nat Rev Microbiol. 2011;9:427-39 pubmed publisher
    ..The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell...
  32. Wen Y, Cheng A, Wang M, Ge H, Shen C, Liu S, et al. A Thymidine Kinase recombinant protein-based ELISA for detecting antibodies to Duck Plague Virus. Virol J. 2010;7:77 pubmed publisher
  33. Pozharskaya V, Torres Gonzalez E, Rojas M, Gal A, Amin M, Dollard S, et al. Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. PLoS ONE. 2009;4:e7559 pubmed publisher
    ..We hypothesize that EMT in this model of virus-induced pulmonary fibrosis is driven by the expression of the transcription factor Twist...
  34. McGeoch D, Rixon F, Davison A. Topics in herpesvirus genomics and evolution. Virus Res. 2006;117:90-104 pubmed
    ..At a finer level, the structure of the capsid shell protein further suggests an element of common origin between herpesviruses and tailed DNA bacteriophages. ..
  35. Aoki T, Hirono I, Kurokawa K, Fukuda H, Nahary R, Eldar A, et al. Genome sequences of three koi herpesvirus isolates representing the expanding distribution of an emerging disease threatening koi and common carp worldwide. J Virol. 2007;81:5058-65 pubmed
    ..related channel catfish virus (ictalurid herpesvirus 1) confirms the proposed place of KHV in the family Herpesviridae, specifically in the branch with fish and amphibian hosts...
  36. El Matbouli M, Rucker U, Soliman H. Detection of Cyprinid herpesvirus-3 (CyHV-3) DNA in infected fish tissues by nested polymerase chain reaction. Dis Aquat Organ. 2007;78:23-8 pubmed
    ..The nested PCR test detected CyHV-3 DNA at a 10-fold lower concentration than a routinely used, 1-round test. Hence, the new method should provide more sensitive diagnosis of CyHV-3 infection among koi and carp populations. ..
  37. Crockford M, Jones J, Crane M, Wilcox G. Molecular detection of a virus, Pilchard herpesvirus, associated with epizootics in Australasian pilchards Sardinops sagax neopilchardus. Dis Aquat Organ. 2005;68:1-5 pubmed
    ..Sequence analysis of amplified fragment resulting from this PCR is different from all known herpesviruses and can therefore distinguish PHV from all known viruses. ..
  38. Qi X, Yang X, Cheng A, Wang M, Zhu D, Jia R. Quantitative analysis of virulent duck enteritis virus loads in experimentally infected ducklings. Avian Dis. 2008;52:338-44 pubmed
  39. Compston L, Sarkobie F, Li C, Candotti D, Opare Sem O, Allain J. Multiplex real-time PCR for the detection and quantification of latent and persistent viral genomes in cellular or plasma blood fractions. J Virol Methods. 2008;151:47-54 pubmed publisher
    ..6% HBV (0.8% DNA+/HBsAg-, 0.8% DNA+/HBsAg+), 0.8% parvovirus B19, and 3.3% GBV-C viraemia in the plasma fraction. The prevalence of four herpesviruses was 1.0% HHV-8, 0.85% CMV, and 8.3% EBV, and no detectable VZV viraemia. ..
  40. Smolarek Benson K, Manire C, Ewing R, Saliki J, Townsend F, Ehlers B, et al. Identification of novel alpha- and gammaherpesviruses from cutaneous and mucosal lesions of dolphins and whales. J Virol Methods. 2006;136:261-6 pubmed
    ..The sequencing data strongly suggest that these viruses are most likely cetacean specific and possibly have coevolved with their cetacean hosts...
  41. Costes B, Raj V, Michel B, Fournier G, Thirion M, Gillet L, et al. The major portal of entry of koi herpesvirus in Cyprinus carpio is the skin. J Virol. 2009;83:2819-30 pubmed publisher
    ..All the data obtained in the present study demonstrate that the skin, and not the gills, is the major portal of entry for KHV in carp. ..
  42. Barton E, White D, Cathelyn J, Brett McClellan K, Engle M, Diamond M, et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature. 2007;447:326-9 pubmed
    ..Thus, whereas the immune evasion capabilities and lifelong persistence of herpesviruses are commonly viewed as solely pathogenic, our data suggest that latency is a symbiotic relationship with immune benefits for the host. ..
  43. Pan H, Cao R, Liu L, Niu M, Zhou B, Chen P, et al. Molecular cloning and sequence analysis of the duck enteritis virus UL5 gene. Virus Res. 2008;136:152-6 pubmed publisher
  44. Gil Z, Rein A, Brader P, Li S, Shah J, Fong Y, et al. Nerve-sparing therapy with oncolytic herpes virus for cancers with neural invasion. Clin Cancer Res. 2007;13:6479-85 pubmed
    ..0001). These results show that NV1023 oncolytic therapy may effectively treat cancers with neural invasion and preserve neural function. These findings hold significant clinical implications for patients with cancer neural invasion. ..
  45. Jia R, Cheng A, Wang M, Qi X, Zhu D, Ge H, et al. Development and evaluation of an antigen-capture ELISA for detection of the UL24 antigen of the duck enteritis virus, based on a polyclonal antibody against the UL24 expression protein. J Virol Methods. 2009;161:38-43 pubmed publisher
    ..90 and 0.67 respectively. These results indicated that the AC-ELISA approach is rapid, sensitive, and reliable for specific detection of DEV antigen. ..
  46. Richter M, Schudel L, Tobler K, Matheis F, Vögtlin A, Vanderplasschen A, et al. Clinical, virological, and immunological parameters associated with superinfection of latently with FeHV-1 infected cats. Vet Microbiol. 2009;138:205-16 pubmed publisher
    ..Since kittens are normally infected with wtFeHV-1 prior to the first immunization, the data described in this study may be valuable for designing future live attenuated FeHV-1 vaccines...
  47. Davidovich M, Dishon A, Ilouze M, Kotler M. Susceptibility of cyprinid cultured cells to cyprinid herpesvirus 3. Arch Virol. 2007;152:1541-6 pubmed
    ..These results indicate that CyHV-3 is not restricted to common carp and koi, but other cyprinids are also vulnerable to the virus...
  48. Grey F, Hook L, Nelson J. The functions of herpesvirus-encoded microRNAs. Med Microbiol Immunol. 2008;197:261-7 pubmed
    ..In this review, we will cover the identification and characterization of miRNAs expressed in the herpesvirus family and discuss the potential significance of their role in viral infection...
  49. Zhao Y, Wang J, Liu F, Ma B. Molecular analysis of US10, S3, and US2 in duck enteritis virus. Virus Genes. 2009;38:243-8 pubmed publisher
    ..Phylogenetic analysis suggests that the DEV C-KCE strain is more closely related to Mardivirus in the alphaherpesvirus subfamily of the Herpesviridae.
  50. Gargano L, Forrest J, Speck S. Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo. J Virol. 2009;83:1474-82 pubmed publisher
  51. Liu F, Ma B, Zhao Y, Zhang Y, Wu Y, Liu X, et al. Characterization of the gene encoding glycoprotein C of duck enteritis virus. Virus Genes. 2008;37:328-32 pubmed publisher
    ..Phylogenetic analysis of the DEV gC gene revealed that the gC gene had a close evolutionary relationship with the subfamily of Alphaherpesvirinae...
  52. Lee D, Lee J, Sugden B. The unfolded protein response and autophagy: herpesviruses rule!. J Virol. 2009;83:1168-72 pubmed publisher
  53. Miyazaki T, Kuzuya Y, Yasumoto S, Yasuda M, Kobayashi T. Histopathological and ultrastructural features of Koi herpesvirus (KHV)-infected carp Cyprinus carpio, and the morphology and morphogenesis of KHV. Dis Aquat Organ. 2008;80:1-11 pubmed publisher
    ..The morphology and morphogenesis of KHV were the same as those of viruses within the family Herpesviridae.
  54. Guo Y, Cheng A, Wang M, Zhou Y. Purification of anatid herpesvirus 1 particles by tangential-flow ultrafiltration and sucrose gradient ultracentrifugation. J Virol Methods. 2009;161:1-6 pubmed publisher
    ..virology to such an extent that they are lagging far behind those on other members of the same family Herpesviridae. Therefore, an efficient method for purifying AHV-1 from cell-culture medium has been developed...
  55. Rosenkranz D, Klupp B, Teifke J, Granzow H, Fichtner D, Mettenleiter T, et al. Identification of envelope protein pORF81 of koi herpesvirus. J Gen Virol. 2008;89:896-900 pubmed publisher
    ..The antiserum was also suitable for the detection of pORF81 in sections of gills, kidneys, hepatopancreas and skin of KHV-infected carp by immunohistochemistry...
  56. Waltzek T, Kelley G, Alfaro M, Kurobe T, Davison A, Hedrick R. Phylogenetic relationships in the family Alloherpesviridae. Dis Aquat Organ. 2009;84:179-94 pubmed publisher
    ..of the fish and amphibian HVs (Alloherpesviridae) separate from the HVs of mammals, birds, and reptiles (Herpesviridae) and the single recognized HV of bivalve mollusks (Malacoherpesviridae) in the order Herpesvirales...
  57. Sadler J, Marecaux E, Goodwin A. Detection of koi herpes virus (CyHV-3) in goldfish, Carassius auratus (L.), exposed to infected koi. J Fish Dis. 2008;31:71-2 pubmed
  58. Cai M, Cheng A, Wang M, Zhao L, Zhu D, Luo Q, et al. Characterization of synonymous codon usage bias in the duck plague virus UL35 gene. Intervirology. 2009;52:266-78 pubmed publisher
    ..The aim was to identify the codon usage bias between the newly identified duck plague virus (DPV) UL35 gene (GenBank accession No. EF643558) and the UL35-like genes of 27 other reference herpesviruses...
  59. Griffin E, Krantz E, Selke S, Huang M, Wald A. Oral mucosal reactivation rates of herpesviruses among HIV-1 seropositive persons. J Med Virol. 2008;80:1153-9 pubmed publisher
    ..These data suggest that separate factors influence mucosal shedding of each of the three classes of herpesviruses but that virological interactions between the pathogens also exist...
  60. Uchii K, Matsui K, Iida T, Kawabata Z. Distribution of the introduced cyprinid herpesvirus 3 in a wild population of common carp, Cyprinus carpio L. J Fish Dis. 2009;32:857-64 pubmed publisher
    ..These results suggest that transmission of CyHV-3 from carriers to naïve common carp is still occurring in Lake Biwa...
  61. Costes B, Fournier G, Michel B, Delforge C, Raj V, Dewals B, et al. Cloning of the koi herpesvirus genome as an infectious bacterial artificial chromosome demonstrates that disruption of the thymidine kinase locus induces partial attenuation in Cyprinus carpio koi. J Virol. 2008;82:4955-64 pubmed publisher
    ..The availability of the KHV BAC is an important advance that will allow the study of viral genes involved in KHV pathogenesis, as well as the production of attenuated recombinant candidate vaccines...
  62. Tan J, Lancaster M, Hyatt A, Van Driel R, Wong F, Warner S. Purification of a herpes-like virus from abalone (Haliotis spp.) with ganglioneuritis and detection by transmission electron microscopy. J Virol Methods. 2008;149:338-41 pubmed publisher
    ..The described method, whilst proving successful for purifying a herpes-like virus from abalone, may also be applicable to other viruses from marine animals...
  63. Hudnall S, Chen T, Allison P, Tyring S, Heath A. Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction. Transfusion. 2008;48:1180-7 pubmed publisher
    ..Also, blood-borne herpesvirus from healthy persistently infected blood donors can lead to active primary infection of immunocompromised transfusion recipients...
  64. Jia R, Cheng A, Wang M, Zhu D, Ge H, Xin H, et al. Cloning, expression, purification and characterization of UL24 partial protein of duck enteritis virus. Intervirology. 2009;52:326-34 pubmed publisher
    ..On the basis of subcellular location, UL24 appeared to be predominantly nuclear membrane-associated, especially at later times in infection, and provided a good tool to further study the biofunctions of UL24 protein...
  65. Goodwin A, Merry G, Sadler J. Detection of the herpesviral hematopoietic necrosis disease agent (Cyprinid herpesvirus 2) in moribund and healthy goldfish: validation of a quantitative PCR diagnostic method. Dis Aquat Organ. 2006;69:137-43 pubmed
    ..The assay detects CyHV-2 not just in clinical cases of HVHN but also in apparently healthy 1 yr old goldfish fingerlings and even in 3 to 5 yr old broodfish...