simian virus 40

Summary

Summary: A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.

Top Publications

  1. Wu A, Chen J, Baserga R. The role of insulin receptor substrate-1 in the oncogenicity of simian virus 40 T antigen. Cell Cycle. 2008;7:1999-2002 pubmed
    The Simian Virus 40 large T antigen (Tag) and the insulin receptor substrate-1 (IRS-1) interact with each other...
  2. Taronna A, Mazzoni E, Corallini A, Bononi I, Pietrobon S, Guerra G, et al. Serological evidence of an early seroconversion to Simian virus 40 in healthy children and adolescents. PLoS ONE. 2013;8:e61182 pubmed publisher
    At present Simian virus 40 (SV40) infection in humans appears to be transmitted independently from early contaminated vaccines...
  3. Butel J. Patterns of polyomavirus SV40 infections and associated cancers in humans: a model. Curr Opin Virol. 2012;2:508-14 pubmed publisher
    ..This model can explain inconsistencies in the published literature of SV40 infections in humans and can guide the design of future studies...
  4. Lowe D, Shearer M, Jumper C, Kennedy R. SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen. Cell Mol Life Sci. 2007;64:803-14 pubmed
    ..This review will also explore how vaccination against SV40 protein products may be used to help prevent and treat individuals with SV40-expressing cancers. ..
  5. Hmeljak J, Kern I, Cor A. No implication of Simian virus 40 in pathogenesis of malignant pleural mesothelioma in Slovenia. Tumori. 2010;96:667-73 pubmed
    Malignant mesothelioma is predominantly caused by asbestos exposure, although the association of Simian virus 40 in its pathogenesis is currently still under debate...
  6. Seo G, Fink L, O HARA B, Atwood W, Sullivan C. Evolutionarily conserved function of a viral microRNA. J Virol. 2008;82:9823-8 pubmed publisher
    ..individuals, JC virus and BK virus, encode miRNAs with the same function as that of the monkey polyomavirus simian virus 40 miRNAs. These miRNAs are expressed late during infection to autoregulate early gene expression...
  7. Atkin S, Griffin B, Dilworth S. Polyoma virus and simian virus 40 as cancer models: history and perspectives. Semin Cancer Biol. 2009;19:211-7 pubmed publisher
    ..Here we review how these discoveries were made, and the influence they have had on our understanding of cancer development. ..
  8. Ewers H, Römer W, Smith A, Bacia K, Dmitrieff S, Chai W, et al. GM1 structure determines SV40-induced membrane invagination and infection. Nat Cell Biol. 2010;12:11-8; sup pp 1-12 pubmed publisher
    Incoming simian virus 40 (SV40) particles enter tight-fitting plasma membrane invaginations after binding to the carbohydrate moiety of GM1 gangliosides in the host cell plasma membrane through pentameric VP1 capsid proteins...
  9. Nevado C, Benito M, Valverde A. Role of insulin receptor and balance in insulin receptor isoforms A and B in regulation of apoptosis in simian virus 40-immortalized neonatal hepatocytes. Mol Biol Cell. 2008;19:1185-98 pubmed publisher
    ..role of the insulin receptor (IR) and the balance of its isoforms A and B in the regulation of apoptosis in simian virus 40 (SV40)-immortalized neonatal hepatocytes...

More Information

Publications82

  1. Iwata T, Mizusawa N, Taketani Y, Itakura M, Yoshimoto K. Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen. Oncogene. 2007;26:6176-83 pubmed
    ..The tumor suppressor protein PF acts as a positive regulator of cell growth similar to an oncoprotein in the presence of SV40 large T antigen. ..
  2. Qi F, Carbone M, Yang H, Gaudino G. Simian virus 40 transformation, malignant mesothelioma and brain tumors. Expert Rev Respir Med. 2011;5:683-97 pubmed publisher
    b>Simian virus 40 (SV40) is a DNA virus isolated in 1960 from contaminated polio vaccines, that induces mesotheliomas, lymphomas, brain and bone tumors, and sarcomas, including osteosarcomas, in hamsters...
  3. Cuesta I, Núñez Ramírez R, Scheres S, Gai D, Chen X, Fanning E, et al. Conformational rearrangements of SV40 large T antigen during early replication events. J Mol Biol. 2010;397:1276-86 pubmed publisher
    The Simian virus 40 (SV40) large tumor antigen (LTag) functions as the replicative helicase and initiator for viral DNA replication...
  4. Dang X, Wuthrich C, Axthelm M, Koralnik I. Productive simian virus 40 infection of neurons in immunosuppressed Rhesus monkeys. J Neuropathol Exp Neurol. 2008;67:784-92 pubmed publisher
    ..Reactivation of simian virus 40 (SV40) in immunosuppressed rhesus monkeys, however, rarely causes a PML-like illness...
  5. Fradet Turcotte A, Morin G, Lehoux M, Bullock P, Archambault J. Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication. Virology. 2010;399:65-76 pubmed publisher
    ..These quantitative and high-throughput assays should greatly facilitate the study of SV40 and HPV31 DNA replication and the identification of small-molecule inhibitors of this process. ..
  6. Seguin S, Ireland A, Gupta T, Wright C, Miyata Y, Wipf P, et al. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res. 2012;96:70-81 pubmed publisher
    ..Both compounds inhibited Simian Virus 40 replication as assessed by plaque assay and quantitative PCR...
  7. Wong C, Vilchez R, Quiroz J, Adam E, Butel J. Ethnic differences in polyomavirus simian virus 40 seroprevalence among women in Houston, Texas. J Infect. 2013;66:67-74 pubmed publisher
    ..Findings are compatible with a model that certain population groups potentially exposed to SV40-contaminated oral poliovaccines have maintained cycles of SV40 infections. ..
  8. Ribeiro T, Fleury M, Granieri E, Castellazzi M, Martini F, Mazzoni E, et al. Investigation of the prevalence of antibodies against neurotropic polyomaviruses BK, JC and SV40 in sera from patients affected by multiple sclerosis. Neurol Sci. 2010;31:517-21 pubmed publisher
  9. Comar M, Rizzardi C, De Zotti R, Melato M, Bovenzi M, Butel J, et al. SV40 multiple tissue infection and asbestos exposure in a hyperendemic area for malignant mesothelioma. Cancer Res. 2007;67:8456-9 pubmed
    ..045). This survey shows that SV40 sustains infections in multiple tissues in malignant mesothelioma patients from a geographic area affected with asbestos-related mesothelioma. ..
  10. Kazakov D, Nemcova J, Mikyskova I, Michal M. Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skin. Am J Dermatopathol. 2007;29:365-9 pubmed
    ..Because all 10 cases studied proved negative for EBV, HPV, and SV40, these viruses seem to play no causal role in LELC of the skin in patients from Central Europe. ..
  11. Mukherjee S, Kler S, Oppenheim A, Zlotnick A. Uncatalyzed assembly of spherical particles from SV40 VP1 pentamers and linear dsDNA incorporates both low and high cooperativity elements. Virology. 2010;397:199-204 pubmed publisher
    ..These data suggest a DNA saturation-dependent nucleation event based on non-specific pentamer-DNA interaction that controls assembly and the ultimate capsid geometry. ..
  12. Gill J, Lowe L, Nguyen J, Liu P, Blake T, Venkatesh B, et al. Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish. Zebrafish. 2010;7:333-41 pubmed publisher
    ..promoter, which has been shown to enforce high-level expression in the testes of transgenic mice, to express Simian virus 40 large T-antigen in zebrafish testes...
  13. Hachana M, Trimeche M, Ziadi S, Amara K, Korbi S. Evidence for a role of the Simian Virus 40 in human breast carcinomas. Breast Cancer Res Treat. 2009;113:43-58 pubmed publisher
    The aim of this study was to investigate whether the Simian Virus 40 (SV40) is implicated in human breast carcinomas (BC).
  14. Mazzoni E, Corallini A, Cristaudo A, Taronna A, Tassi G, Manfrini M, et al. High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma. Proc Natl Acad Sci U S A. 2012;109:18066-71 pubmed publisher
    ..043) than in the control group (15%) represented by healthy subjects (n = 168) with the same median age (66 y) and sex. Our results suggest that SV40 is associated with a subset of MPM and circulates in humans...
  15. Roitman Shemer V, Stokrova J, Forstova J, Oppenheim A. Assemblages of simian virus 40 capsid proteins and viral DNA visualized by electron microscopy. Biochem Biophys Res Commun. 2007;353:424-30 pubmed
    ..Sp1 was absent from mature virions. The findings suggest that multiple capsomers attach simultaneously to the viral genome, increasing their local concentration, facilitating rapid, concerted assembly reaction and removal of Sp1...
  16. Kumar S, Rangarajan A. Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. J Virol. 2009;83:8565-74 pubmed publisher
    ..Using an in vitro transformation model where the presence of the simian virus 40 (SV40) small T (ST) antigen has been shown to be critical for tumorigenic transformation, we investigated ..
  17. Butin Israeli V, Drayman N, Oppenheim A. Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways. J Virol. 2010;84:3431-42 pubmed publisher
    The infection process by simian virus 40 (SV40) and entry of its genome into nondividing cells are only partly understood...
  18. Tsukamoto H, Kawano M, Inoue T, Enomoto T, Takahashi R, Yokoyama N, et al. Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles. Genes Cells. 2007;12:1267-79 pubmed
    The simian virus 40 (SV40) particle is mainly composed of the major capsid protein termed VP1...
  19. Patel N, Vilchez R, Killen D, Zanwar P, Sroller V, Eldin K, et al. Detection of polyomavirus SV40 in tonsils from immunocompetent children. J Clin Virol. 2008;43:66-72 pubmed publisher
    BK virus (BKV), JC virus (JCV) and simian virus 40 (SV40) are nonenveloped DNA viruses, members of the family Polyomaviridae...
  20. Comar M, Zanotta N, Pesel G, Visconti P, Maestri I, Rinaldi R, et al. Asbestos and SV40 in malignant pleural mesothelioma from a hyperendemic area of north-eastern Italy. Tumori. 2012;98:210-4 pubmed publisher
  21. Magaldi T, Buch M, Murata H, Erickson K, Neu U, Garcea R, et al. Mutations in the GM1 binding site of simian virus 40 VP1 alter receptor usage and cell tropism. J Virol. 2012;86:7028-42 pubmed publisher
    ..receptor specificity and how changes in receptor usage affect tropism, we studied the primate polyomavirus simian virus 40 (SV40), which uses the ganglioside GM1 as a receptor that mediates cell binding and entry...
  22. Khopde S, Roy R, Simmons D. The binding of topoisomerase I to T antigen enhances the synthesis of RNA-DNA primers during simian virus 40 DNA replication. Biochemistry. 2008;47:9653-60 pubmed publisher
    Topoisomerase I (topo I) is required for the proper initiation of simian virus 40 (SV40) DNA replication...
  23. Ben nun Shaul O, Bronfeld H, Reshef D, Schueler Furman O, Oppenheim A. The SV40 capsid is stabilized by a conserved pentapeptide hinge of the major capsid protein VP1. J Mol Biol. 2009;386:1382-91 pubmed publisher
    The simian virus 40 (SV40) outer shell is composed of 72 pentamers of VP1. The core of the VP1 monomer is a beta-barrel with jelly-roll topology and extending N- and C-terminal arms...
  24. Butin Israeli V, Ben nun Shaul O, Kopatz I, Adam S, Shimi T, Goldman R, et al. Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry. Nucleus. 2011;2:320-30 pubmed publisher
    ..As SV40 serves as a paradigm for the pathogenic human BK, JC and Merkel cell polyomavirus, this study suggests nuclear entry as a novel drug target for these infections...
  25. Tei S, Saitoh N, Funahara T, Iida S, Nakatsu Y, Kinoshita K, et al. Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2. J Cell Sci. 2009;122:3190-8 pubmed publisher
    ..Here, we report that simian virus 40 (SV40) large T antigen interacts with the transforming acidic coiled-coil-containing protein TACC2, which is ..
  26. Inoue T, Tsai B. A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol. PLoS Pathog. 2011;7:e1002037 pubmed publisher
    ..They also suggest that the ER membrane supports passage of a large particle, potentially through either a sizeable protein-conducting channel or the lipid bilayer...
  27. Aldrich J, Lowe D, Shearer M, Winn R, Jumper C, Bright R, et al. CD4+ T lymphocytes are critical mediators of tumor immunity to simian virus 40 large tumor antigen induced by vaccination with plasmid DNA. J Virol. 2011;85:7216-24 pubmed publisher
    A mechanistic analysis of tumor immunity directed toward the viral oncoprotein simian virus 40 (SV40) large tumor antigen (Tag) has previously been described by our laboratory for scenarios of recombinant Tag immunization in BALB/c mice...
  28. Amara K, Trimeche M, Ziadi S, Laatiri A, Hachana M, Sriha B, et al. Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes. Int J Cancer. 2007;121:2693-702 pubmed
    ..The significant association of promoter hypermethylation of multiple TSGs with the presence of SV40 DNA in DLBCLs supports a functional effect of the virus in those lymphomas...
  29. Rathi A, Cantalupo P, Sarkar S, Pipas J. Induction of interferon-stimulated genes by Simian virus 40 T antigens. Virology. 2010;406:202-11 pubmed publisher
    b>Simian virus 40 (SV40) large T antigen (TAg) is a multifunctional oncoprotein essential for productive viral infection and for cellular transformation...
  30. Li F, Li K, Cui Z, Zhang Z, Wei H, Gao D, et al. Viral coat proteins as flexible nano-building-blocks for nanoparticle encapsulation. Small. 2010;6:2301-8 pubmed publisher
    ..We previously generated virus-based nanoparticles (VNPs) of simian virus 40 (SV40) containing quantum dots (QDs) for cellular imaging...
  31. Kawano M, Xing L, Tsukamoto H, Inoue T, Handa H, Cheng R. Calcium bridge triggers capsid disassembly in the cell entry process of simian virus 40. J Biol Chem. 2009;284:34703-12 pubmed publisher
    ..Our data also indicate that calcium depletion-induced SV40 capsid disassembly may occur in the ER region and that this is essential for successful SV40 infection...
  32. Amara K, Trimeche M, Ziadi S, Laatiri A, Mestiri S, Sriha B, et al. Presence of simian virus 40 in diffuse large B-cell lymphomas in Tunisia correlates with germinal center B-cell immunophenotype, t(14;18) translocation, and P53 accumulation. Mod Pathol. 2008;21:282-96 pubmed publisher
    Previously we have reported the presence of simian virus 40 DNA in 56% of diffuse large B-cell lymphomas in Tunisia...
  33. Daniels R, Sadowicz D, Hebert D. A very late viral protein triggers the lytic release of SV40. PLoS Pathog. 2007;3:e98 pubmed publisher
    How nonenveloped viruses such as simian virus 40 (SV40) trigger the lytic release of their progeny is poorly understood...
  34. Li F, Chen H, Zhang Y, Chen Z, Zhang Z, Zhang X, et al. Three-dimensional gold nanoparticle clusters with tunable cores templated by a viral protein scaffold. Small. 2012;8:3832-8 pubmed publisher
    ..Here it is illustrated that the VNP of simian virus 40 (SV40) is a powerful scaffold in directing the assembly of 3D hybrid nanoarchitectures with one NP ..
  35. Bochkareva E, Martynowski D, Seitova A, Bochkarev A. Structure of the origin-binding domain of simian virus 40 large T antigen bound to DNA. EMBO J. 2006;25:5961-9 pubmed
    ..T antigen (T-ag) protein binds to and activates DNA replication from the origin of DNA replication (ori) in simian virus 40 (SV40)...
  36. Chandok G, Kapoor K, Brick R, Sidorova J, Krasilnikova M. A distinct first replication cycle of DNA introduced in mammalian cells. Nucleic Acids Res. 2011;39:2103-15 pubmed publisher
    ..This work demonstrates, for the first time, differences in the replication progression during the first and subsequent replication cycles in mammalian cells...
  37. Rivera Z, Strianese O, Bertino P, Yang H, Pass H, Carbone M. The relationship between simian virus 40 and mesothelioma. Curr Opin Pulm Med. 2008;14:316-21 pubmed publisher
    b>Simian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of simian virus 40 in malignant mesothelioma is discussed in this review.
  38. Balakrishnan L, Milavetz B. Histone hyperacetylation during SV40 transcription is regulated by p300 and RNA polymerase II translocation. J Mol Biol. 2007;371:1022-37 pubmed
    ..p300 on the presence of RNAPII, p300, hyperacetylated H4 and H3 and unmodified H4 and H3 in transcribing simian virus 40 (SV40) minichromosomes were determined...
  39. Corallini A, Mazzoni E, Taronna A, Manfrini M, Carandina G, Guerra G, et al. Specific antibodies reacting with simian virus 40 capsid protein mimotopes in serum samples from healthy blood donors. Hum Immunol. 2012;73:502-10 pubmed publisher
    b>Simian virus 40 (SV40), a small DNA tumor virus, was inadvertently administered to human populations with the use of contaminated vaccines...
  40. Mazzoni E, Rigolin G, Alaribe F, Pancaldi C, Maniero S, Comar M, et al. Simian virus 40 efficiently infects human T lymphocytes and extends their lifespan. Exp Hematol. 2012;40:466-76 pubmed publisher
    ..from the peripheral blood mononuclear cells of healthy blood donors were experimentally infected with simian virus 40 (SV40), a small DNA tumor virus...
  41. Louboutin J, Liu B, Chekmasova A, Reyes B, Van Bockstaele E, Strayer D. Delivering genes to the organ-localized immune system: long-term results of direct intramarrow transduction. J Gene Med. 2007;9:843-51 pubmed
  42. Boichuk S, Hu L, Hein J, Gjoerup O. Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen. J Virol. 2010;84:8007-20 pubmed publisher
    We demonstrated previously that expression of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is sufficient to induce the hallmarks of a cellular DNA damage response (DDR), such as focal accumulation of gamma-H2AX ..
  43. Yu Y, Alwine J. Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. J Virol. 2008;82:4521-6 pubmed publisher
    ..We previously showed that wild-type (WT) simian virus 40 (SV40) large T antigen (TAg) inhibits apoptosis via the activation of PI3K/Akt signaling...
  44. Sáenz Robles M, Markovics J, Chong J, Opavsky R, Whitehead R, Leone G, et al. Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2. J Virol. 2007;81:13191-9 pubmed
    The simian virus 40 large T antigen contributes to neoplastic transformation, in part, by targeting the Rb family of tumor suppressors...
  45. Cantalupo P, Sáenz Robles M, Rathi A, Beerman R, Patterson W, Whitehead R, et al. Cell-type specific regulation of gene expression by simian virus 40 T antigens. Virology. 2009;386:183-91 pubmed publisher
  46. Zhao X, Madden Fuentes R, Lou B, Pipas J, Gerhardt J, Rigell C, et al. Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells. J Virol. 2008;82:5316-28 pubmed publisher
    Although the mechanism of simian virus 40 (SV40) DNA replication has been extensively investigated with cell extracts, viral DNA replication in productively infected cells utilizes additional viral and host functions whose interplay ..
  47. Li P, Itoh N, Watanabe M, Shi Y, Liu P, Yang H, et al. Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigens. J Virol. 2009;83:37-46 pubmed publisher
    ..The major capsid protein Vp1 of simian virus 40 forms a series of disulfide-linked intermediates during folding and capsid formation...
  48. Li L, McCormack A, Nicholson J, Fabarius A, Hehlmann R, Sachs R, et al. Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function. Cancer Genet Cytogenet. 2009;188:1-25 pubmed publisher
    ..Karyotypes as a whole, rather than specific mutations, explain the individuality, fluidity, and phenotypic complexity of cancers...
  49. Giorda K, Raghava S, Hebert D. The Simian virus 40 late viral protein VP4 disrupts the nuclear envelope for viral release. J Virol. 2012;86:3180-92 pubmed publisher
    b>Simian virus 40 (SV40) appears to initiate cell lysis by expressing the late viral protein VP4 at the end of infection to aid in virus dissemination...
  50. Meinke G, Phelan P, Fradet Turcotte A, Archambault J, Bullock P. Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain. Acta Crystallogr D Biol Crystallogr. 2011;67:560-7 pubmed publisher
    The modular multifunctional protein large T antigen (T-ag) from simian virus 40 orchestrates many of the events needed for replication of the viral double-stranded DNA genome...
  51. Jeong K, Gill J, Nose V, Parlow A, Carroll R, Kaiser U. Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis. Endocrinology. 2009;150:3383-91 pubmed publisher
    ..The 1.2-kb gene promoter fused to the simian virus 40 large T antigen (TAg) was used to generate transgenic mice that form gonadotrope-derived pituitary tumors at ..
  52. Neu U, Woellner K, Gauglitz G, Stehle T. Structural basis of GM1 ganglioside recognition by simian virus 40. Proc Natl Acad Sci U S A. 2008;105:5219-24 pubmed publisher
    b>Simian virus 40 (SV40) has been a paradigm for understanding attachment and entry of nonenveloped viruses, viral DNA replication, and virus assembly, as well as for endocytosis pathways associated with caveolin and cholesterol...
  53. Engel S, Heger T, Mancini R, Herzog F, Kartenbeck J, Hayer A, et al. Role of endosomes in simian virus 40 entry and infection. J Virol. 2011;85:4198-211 pubmed publisher
    After binding to its cell surface receptor ganglioside GM1, simian virus 40 (SV40) is endocytosed by lipid raft-mediated endocytosis and slowly transported to the endoplasmic reticulum, where partial uncoating occurs...
  54. Khalili K, Sariyer I, Safak M. Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation. J Cell Physiol. 2008;215:309-19 pubmed
    ..In this short review, we will focus on the structural and functional features of one polyomavirus transforming protein, that is, the small t-antigen of the human neurotropic JC virus (JCV) and the simian virus, SV40...
  55. Goodwin E, Lipovsky A, Inoue T, Magaldi T, Edwards A, Van Goor K, et al. BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. MBio. 2011;2:e00101-11 pubmed publisher
    b>Simian virus 40 (SV40) is a nonenveloped DNA virus that traffics through the endoplasmic reticulum (ER) en route to the nucleus, but the mechanisms of capsid disassembly and ER exit are poorly understood...
  56. Mukherjee S, Abd El Latif M, Bronstein M, Ben nun Shaul O, Kler S, Oppenheim A. High cooperativity of the SV40 major capsid protein VP1 in virus assembly. PLoS ONE. 2007;2:e765 pubmed
    ..In addition, the SV40-based nanoparticles described here are potential gene therapy vectors that combine efficient gene delivery with safety and flexibility...
  57. Wang T, Zhang Z, Gao D, Li F, Wei H, Liang X, et al. Encapsulation of gold nanoparticles by simian virus 40 capsids. Nanoscale. 2011;3:4275-82 pubmed publisher
    ..We previously constructed a hybrid structure comprising quantum dots encapsulated by simian virus 40 (SV40) capsids for imaging viral infection pathways...
  58. Wright C, Seguin S, Fewell S, Zhang H, Ishwad C, Vats A, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009;141:71-80 pubmed publisher
    ..In contrast, the replication of one member of this family, Simian Virus 40 (SV40), is robust and has been well-characterized...
  59. Vilchez R. Viruses from nonhuman primates. Emerg Infect Dis. 2006;12:1802-3; author reply 1803 pubmed
  60. Lowe D, Shearer M, Jumper C, Bright R, Kennedy R. Tumor immunity against a simian virus 40 oncoprotein requires CD8+ T lymphocytes in the effector immune phase. J Virol. 2010;84:883-93 pubmed publisher
    The required activities of CD4(+) T cells and antibody against the virally encoded oncoprotein simian virus 40 (SV40) Tag have previously been demonstrated by our laboratory to be mediators in achieving antitumor responses and tumor ..
  61. Nakanishi A, Itoh N, Li P, Handa H, Liddington R, Kasamatsu H. Minor capsid proteins of simian virus 40 are dispensable for nucleocapsid assembly and cell entry but are required for nuclear entry of the viral genome. J Virol. 2007;81:3778-85 pubmed
    We investigated the roles of simian virus 40 capsid proteins in the viral life cycle by analyzing point mutants in Vp1 and Vp2/3, as well as a deletion mutant lacking the Vp2/3 coding sequence...
  62. Kjaerheim K, Røe O, Waterboer T, Sehr P, Rizk R, Dai H, et al. Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples. Int J Cancer. 2007;120:2459-65 pubmed
    The rhesus monkey virus Simian Virus 40 (SV40) is a member of the polyomavirus family...
  63. Chruściel M, Bodek G, Kirtiklis L, Lewczuk B, Hyder C, Blitek A, et al. Immortalization of swine umbilical vein endothelial cells (SUVECs) with the simian virus 40 large-T antigen. Mol Reprod Dev. 2011;78:597-610 pubmed publisher
    ..We have generated an immortalized endothelial cell line, G-1410, using Simian virus 40 T-antigen (SV40 T-ag) primarily to overcome the short life span before the onset of senescence and high ..
  64. Park K, Hallows J, Chakrabarty P, Davies P, Vincent I. Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J Neurosci. 2007;27:2969-78 pubmed
    ..transgenic mice with forced cell cycle activation in postmitotic neurons via conditional expression of the simian virus 40 large T antigen (TAg) oncogene...
  65. Greenleaf W, Shen J, Gai D, Chen X. Systematic study of the functions for the residues around the nucleotide pocket in simian virus 40 AAA+ hexameric helicase. J Virol. 2008;82:6017-23 pubmed publisher
    The high-resolution structural data for simian virus 40 large-T-antigen helicase revealed a set of nine residues bound to ATP/ADP directly or indirectly...
  66. Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, et al. Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen. Proc Natl Acad Sci U S A. 2014;111:3371-6 pubmed publisher
    b>Simian virus 40 (SV40) large tumor antigen (LT) triggers oncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of the retinoblastoma family...
  67. Fanning E, Zhao K. SV40 DNA replication: from the A gene to a nanomachine. Virology. 2009;384:352-9 pubmed publisher
    Duplication of the simian virus 40 (SV40) genome is the best understood eukaryotic DNA replication process to date. Like most prokaryotic genomes, the SV40 genome is a circular duplex DNA organized in a single replicon...
  68. Li F, Zhang Z, Peng J, Cui Z, Pang D, Li K, et al. Imaging viral behavior in Mammalian cells with self-assembled capsid-quantum-dot hybrid particles. Small. 2009;5:718-26 pubmed publisher
    ..movement, and localization of viruses in living cells, QD-containing virus-like particles (VLPs) of simian virus 40 (SV40), termed SVLP-QDs, are constructed by in vitro self-assembly of the major capsid protein of SV40...
  69. Price M, Darnton A, McElvenny D, Hodgson J. Simian virus 40 and mesothelioma in Great Britain. Occup Med (Lond). 2007;57:564-8 pubmed
    b>Simian virus 40 (SV40) is a DNA virus that has been shown capable of infecting and transforming cells in various species...
  70. Kukura P, Ewers H, Muller C, Renn A, Helenius A, Sandoghdar V. High-speed nanoscopic tracking of the position and orientation of a single virus. Nat Methods. 2009;6:923-7 pubmed publisher
    ..fluorescence microscopy to visualize both position and orientation of single quantum dot-labeled Simian virus 40 (SV40) particles...
  71. Rohaly G, Korf K, Dehde S, Dornreiter I. Simian virus 40 activates ATR-Delta p53 signaling to override cell cycle and DNA replication control. J Virol. 2010;84:10727-47 pubmed publisher
    During infection, simian virus 40 (SV40) attempts to take hold of the cell, while the host responds with various defense systems, including the ataxia-telangiectasia mutated/ATM-Rad3 related (ATM/ATR)-mediated DNA damage response ..
  72. Campanero Rhodes M, Smith A, Chai W, Sonnino S, Mauri L, Childs R, et al. N-glycolyl GM1 ganglioside as a receptor for simian virus 40. J Virol. 2007;81:12846-58 pubmed
    ..glycolipids and neoglycolipids representative of diverse mammalian glycans, we examined interactions of simian virus 40 (SV40) with potential carbohydrate receptors...
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    ..Nevertheless, the low prevalence of polyomavirus, in comparison with the lymphotropic HHV-6, suggests that these tissues are unlikely to be the preferred site of polyomavirus latency, at least in younger children...