jc virus

Summary

Summary: A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.

Top Publications

  1. Lopez V, Gutierrez C, Sola E, Garcia I, Burgos D, Cabello M, et al. Does JC polyomavirus cause nephropathy in renal transplant patients?. Transplant Proc. 2010;42:2889-91 pubmed publisher
    ..In renal transplant patients, the incidence of BKV and JCV viruria was similar, although in our series the JCV serotype did not cause viremia or PVN. Our experience suggested that JCV did not have the ability to cause PVN. ..
  2. Frohman E, Monaco M, Remington G, Ryschkewitsch C, Jensen P, Johnson K, et al. JC virus in CD34+ and CD19+ cells in patients with multiple sclerosis treated with natalizumab. JAMA Neurol. 2014;71:596-602 pubmed publisher
    Infection with JC virus (JCV) may lead to development of demyelinating progressive multifocal leukoencephalopathy in patients with multiple sclerosis (MS) who are treated with natalizumab...
  3. Burnett Hartman A, Newcomb P, Potter J. Infectious agents and colorectal cancer: a review of Helicobacter pylori, Streptococcus bovis, JC virus, and human papillomavirus. Cancer Epidemiol Biomarkers Prev. 2008;17:2970-9 pubmed publisher
    ..Helicobacter pylori, Streptococcus bovis, JC virus, and human papillomavirus have all been evaluated as possible etiologic agents for colorectal cancer...
  4. White M, Khalili K. Pathogenesis of progressive multifocal leukoencephalopathy--revisited. J Infect Dis. 2011;203:578-86 pubmed publisher
    ..of the central nervous system that is rare even though the proven etiological agent of PML, the polyomavirus JC (JC virus), is ubiquitous within the human population...
  5. Viscidi R, Rollison D, Sondak V, Silver B, Messina J, Giuliano A, et al. Age-specific seroprevalence of Merkel cell polyomavirus, BK virus, and JC virus. Clin Vaccine Immunol. 2011;18:1737-43 pubmed publisher
    ..In agreement with results from other studies, we found an association between MCPyV seropositivity and MCC, and higher levels of serum MCPyV capsid antibodies in MCC patients than in controls...
  6. Neu U, Maginnis M, Palma A, Ströh L, Nelson C, Feizi T, et al. Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif. Cell Host Microbe. 2010;8:309-19 pubmed publisher
    ..Our findings provide a powerful platform for the development of antiviral compounds. ..
  7. Dang X, Vidal J, Oliveira A, Simpson D, Morgello S, Hecht J, et al. JC virus granule cell neuronopathy is associated with VP1 C terminus mutants. J Gen Virol. 2012;93:175-83 pubmed publisher
    ..These data highlight an important and previously overlooked aspect of JCV-pathogenesis. Detection of GCN-type JCV strains in CSF may help clinicians diagnose JCV GCN...
  8. Nelson C, Derdowski A, Maginnis M, O Hara B, Atwood W. The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry. Virology. 2012;428:30-40 pubmed publisher
    ..These pentamers represent a new tool to study polyomavirus entry, and will be particularly useful in studying recently identified polyomaviruses that are difficult to propagate. ..
  9. Saribas A, White M, Safak M. JC virus agnoprotein enhances large T antigen binding to the origin of viral DNA replication: evidence for its involvement in viral DNA replication. Virology. 2012;433:12-26 pubmed publisher
    Agnoprotein is required for the successful completion of the JC virus (JCV) life cycle and was previously shown to interact with JCV large T-antigen (LT-Ag)...

More Information

Publications102 found, 100 shown here

  1. Seo G, Fink L, O HARA B, Atwood W, Sullivan C. Evolutionarily conserved function of a viral microRNA. J Virol. 2008;82:9823-8 pubmed publisher
    ..Here, we report that two human polyomaviruses associated with serious disease in immunocompromised individuals, JC virus and BK virus, encode miRNAs with the same function as that of the monkey polyomavirus simian virus 40 miRNAs...
  2. Orba Y, Suzuki T, Makino Y, Kubota K, Tanaka S, Kimura T, et al. Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling. J Biol Chem. 2010;285:1544-54 pubmed publisher
    Large T antigen (TAg) of the human polyomavirus JC virus (JCV) possesses DNA binding and helicase activities, which, together with various cellular proteins, are required for replication of the viral genome...
  3. Broekema N, Imperiale M. Efficient propagation of archetype BK and JC polyomaviruses. Virology. 2012;422:235-41 pubmed publisher
    ..Significant replication was not observed for Merkel cell, KI, or WU polyomaviruses. 293TT cells provide a means of propagating archetype BKPyV and JCPyV for detailed study. ..
  4. Olsson T, Achiron A, Alfredsson L, Berger T, Brassat D, Chan A, et al. Anti-JC virus antibody prevalence in a multinational multiple sclerosis cohort. Mult Scler. 2013;19:1533-8 pubmed publisher
    b>JC virus (JCV) is an opportunistic virus known to cause progressive multifocal leukoencephalopathy...
  5. Abdel Aziz H, Murai Y, Hong M, Kutsuna T, Takahashi H, Nomoto K, et al. Detection of the JC virus genome in lung cancers: possible role of the T-antigen in lung oncogenesis. Appl Immunohistochem Mol Morphol. 2007;15:394-400 pubmed
    The JC virus (JCV) infects a large proportion of the population worldwide and 80% to 90% of adults are seropositive and it may be activated in immunodeficient patients, resulting in progressive multifocal leukoencephalopathy...
  6. Bellizzi A, Nardis C, Anzivino E, Rodìo D, Fioriti D, Mischitelli M, et al. Human polyomavirus JC reactivation and pathogenetic mechanisms of progressive multifocal leukoencephalopathy and cancer in the era of monoclonal antibody therapies. J Neurovirol. 2012;18:1-11 pubmed publisher
  7. Rinaldi L, Rinaldi F, Perini P, Calabrese M, Seppi D, Grossi P, et al. No evidence of JC virus reactivation in natalizumab treated multiple sclerosis patients: an 18 month follow-up study. J Neurol Neurosurg Psychiatry. 2010;81:1345-50 pubmed publisher
    ..has been associated with progressive multifocal leucoencephalopathy (PML), a potentially fatal disease caused by JC virus (JCV), which is not predictable by specific markers...
  8. Jilek S, Jaquiéry E, Hirsch H, Lysandropoulos A, Canales M, Guignard L, et al. Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study. Lancet Neurol. 2010;9:264-72 pubmed publisher
    ..We aimed to better understand the associations between JC virus, which causes PML, and natalizumab treatment...
  9. Delbue S, Ferraresso M, Elia F, Belingheri M, Carloni C, Signorini L, et al. Investigation of polyomaviruses replication in pediatric patients with nephropathy receiving rituximab. J Med Virol. 2012;84:1464-70 pubmed publisher
    ..No significant difference was found in the mean viral loads and in the viral molecular characterizations between the two groups. The polyomaviruses replication was not associated with rituximab therapy in children...
  10. Rodrigues C, Pinto D, Medeiros R. Molecular epidemiology characterization of the urinary excretion of polyomavirus in healthy individuals from Portugal--a Southern European population. J Med Virol. 2007;79:1194-8 pubmed
    ..Further studies are needed to evaluate the prevalence of polyomaviruses in healthy individuals, in order to understand the biological behaviour of these viruses. ..
  11. Del Valle L, White M, Khalili K. Potential mechanisms of the human polyomavirus JC in neural oncogenesis. J Neuropathol Exp Neurol. 2008;67:729-40 pubmed publisher
    ..Here, we discuss the mechanisms involved in JCV oncogenesis, briefly review studies that do and do not support a causative role for this virus in human CNS tumors, and identify key issues for future research. ..
  12. Lanzafame M, Ferrari S, Lattuada E, Corsini F, Deganello R, Vento S, et al. Mirtazapine in an HIV-1 infected patient with progressive multifocal leukoencephalopathy. Infez Med. 2009;17:35-7 pubmed
    ..Further studies are necessary to determine the effect of serotonin receptor antagonist in treating PML associated to HIV. ..
  13. Cinque P, Koralnik I, Gerevini S, Miro J, Price R. Progressive multifocal leukoencephalopathy in HIV-1 infection. Lancet Infect Dis. 2009;9:625-36 pubmed publisher
    ..The reasons for variability in the natural history of progressive multifocal leukoencephalopathy and treatment responses are largely undefined, and more specific and rational approaches to management are needed...
  14. Sariyer I, Saribas A, White M, Safak M. Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content. Virol J. 2011;8:255 pubmed publisher
    ..In this work, the functional role of JCV and SV40 agnoproteins in virion release was investigated using a point mutant (Pt) of each virus, where the ATG codon of agnoprotein was mutated to abrogate its expression...
  15. White M, Safak M, Khalili K. Regulation of gene expression in primate polyomaviruses. J Virol. 2009;83:10846-56 pubmed publisher
    ..occurs in the tubular epithelial cells of the kidney, causing nephropathy in kidney allograft recipients, while JC virus (JCV) replication occurs in the glial cells of the central nervous system, where it causes progressive multifocal ..
  16. Wollebo H, Melis S, Khalili K, Safak M, White M. Cooperative roles of NF-?B and NFAT4 in polyomavirus JC regulation at the KB control element. Virology. 2012;432:146-54 pubmed publisher
    ..This interplay is inhibited by C/EBP? and by agents that block the calcineurin/NFAT signaling pathway. The importance of these events in the regulation of JCV latency and reactivation is discussed. ..
  17. Perkins M, Ryschkewitsch C, Liebner J, Monaco M, Himelfarb D, Ireland S, et al. Changes in JC virus-specific T cell responses during natalizumab treatment and in natalizumab-associated progressive multifocal leukoencephalopathy. PLoS Pathog. 2012;8:e1003014 pubmed publisher
    Progressive multifocal leukoencephalopathy (PML) induced by JC virus (JCV) is a risk for natalizumab-treated multiple sclerosis (MS) patients...
  18. Merabova N, Kaniowska D, Kaminski R, Deshmane S, White M, Amini S, et al. JC virus agnoprotein inhibits in vitro differentiation of oligodendrocytes and promotes apoptosis. J Virol. 2008;82:1558-69 pubmed publisher
    ..responsible for the formation of myelin sheath in the central nervous system, with the human neurotropic virus JC virus (JCV) causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML)...
  19. Sunyaev S, Lugovskoy A, Simon K, Gorelik L. Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). PLoS Genet. 2009;5:e1000368 pubmed publisher
    PML is a progressive and mostly fatal demyelinating disease caused by JC virus infection and destruction of infected oligodendrocytes in multiple brain foci of susceptible individuals...
  20. Warnke C, Pawlita M, Dehmel T, Posevitz Fejfar A, Hartung H, Wiendl H, et al. An assay to quantify species-specific anti-JC virus antibody levels in MS patients. Mult Scler. 2013;19:1137-44 pubmed publisher
    The StratifyJCV® test is a qualitative assay to classify MS patients as anti-JC virus (JCV) antibody positive or negative...
  21. Vasishta R, Pasricha N, Nath A, Sehgal S. The absence of JC virus antigens in Indian children with medulloblastomas. Indian J Pathol Microbiol. 2009;52:42-5 pubmed
    The human polyoma virus, also known as the JC virus (JCV), replicates predominantly in the oligodendrocytes, the myelin producing cells in the central nervous system and results in the fatal demyelinating disease progressive multifocal ..
  22. Schwab N, Ulzheimer J, Fox R, Schneider Hohendorf T, Kieseier B, Monoranu C, et al. Fatal PML associated with efalizumab therapy: insights into integrin ?L?2 in JC virus control. Neurology. 2012;78:458-67; discussion 465 pubmed publisher
    ..Both patients developed progressive cognitive and motor deficits, and JC virus was identified in CSF...
  23. Lopez V, Gutierrez C, Burgos D, Gonzalez Molina M, Cabello M, Sola E, et al. Prospective study of infection and nephropathy due to BK and JC polyomavirus in 76 kidney transplant recipients. Transplant Proc. 2008;40:2927-9 pubmed publisher
    ..No patient lost the graft due to nephropathy. The detection of BK and JC polyomavirus by protocolized PCR enabled an early diagnosis of nephropathy, preventing graft loss with good renal function at 1 year. ..
  24. GASPAROVIC M, Maginnis M, O Hara B, Dugan A, Atwood W. Modulation of PML protein expression regulates JCV infection. Virology. 2009;390:279-88 pubmed publisher
    b>JC virus (JCV) is a human polyomavirus that infects the majority of the human population worldwide. It is responsible for the fatal demyelinating disease Progressive Multifocal Leukoencephalopathy...
  25. Pires E, Bernardino Vallinoto C, Alves D, Migone S, Machado L, Ishak M, et al. Prevalence of infection by JC and BK polyomaviruses in kidney transplant recipients and patients with chronic renal disease. Transpl Infect Dis. 2011;13:633-7 pubmed publisher
  26. Nakamichi K, Mizusawa H, Yamada M, Kishida S, Miura Y, Shimokawa T, et al. Characteristics of progressive multifocal leukoencephalopathy clarified through internet-assisted laboratory surveillance in Japan. BMC Neurol. 2012;12:121 pubmed publisher
    Progressive multifocal leukoencephalopathy (PML), a rare but fatal demyelinating disease caused by JC virus (JCV), occurs mainly in immunocompromised patients...
  27. Marzocchetti A, Wuthrich C, Tan C, Tompkins T, Bernal Cano F, Bhargava P, et al. Rearrangement of the JC virus regulatory region sequence in the bone marrow of a patient with rheumatoid arthritis and progressive multifocal leukoencephalopathy. J Neurovirol. 2008;14:455-8 pubmed publisher
    ..Further studies will be needed to determine the prevalence of JCV in bone marrow of immunosuppressed individuals at risk of PML and characterize the RR and phenotype of these JCV isolates. ..
  28. Brickelmaier M, Lugovskoy A, Kartikeyan R, Reviriego Mendoza M, Allaire N, Simon K, et al. Identification and characterization of mefloquine efficacy against JC virus in vitro. Antimicrob Agents Chemother. 2009;53:1840-9 pubmed publisher
    ..leukoencephalopathy (PML) is a rare but frequently fatal disease caused by the uncontrolled replication of JC virus (JCV), a polyomavirus, in the brains of some immunocompromised individuals...
  29. Caracciolo V, Macaluso M, D Agostino L, Montanari M, Scheff J, Reiss K, et al. Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma. J Cell Biochem. 2010;110:182-90 pubmed publisher
    ..b>JC virus (JCV) is a human polyomavirus...
  30. Nakamichi K, Kurane I, Saijo M. Evaluation of a quantitative real-time PCR assay for the detection of JC polyomavirus DNA in cerebrospinal fluid without nucleic acid extraction. Jpn J Infect Dis. 2011;64:211-6 pubmed
    ..These data demonstrate that the real-time PCR assay introduced in this study can serve as a rapid and cost-effective method of testing for JCV without DNA extraction and thereby facilitate the assessment of PML. ..
  31. Comar M, Delbue S, Lepore L, Martelossi S, Radillo O, Ronfani L, et al. Latent viral infections in young patients with inflammatory diseases treated with biological agents: prevalence of JC virus genotype 2. J Med Virol. 2013;85:716-22 pubmed publisher
    Treatment with biological drugs is associated with increased susceptibility to viral infections. Reactivation of JC virus (JCV) and human cytomegalovirus (HCMV) in adults after therapy has been documented...
  32. Nosho K, Shima K, Kure S, Irahara N, Baba Y, Chen L, et al. JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. Neoplasia. 2009;11:87-95 pubmed
    b>JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize beta-catenin...
  33. Vilkin A, Ronen Z, Levi Z, Morgenstern S, Halpern M, Niv Y. Presence of JC virus DNA in the tumor tissue and normal mucosa of patients with sporadic colorectal cancer (CRC) or with positive family history and Bethesda criteria. Dig Dis Sci. 2012;57:79-84 pubmed publisher
    b>JC virus (JCV) may infect the gastrointestinal tract in childhood, and, by encoding a gene for T-antigen (T Ag), can initiate chromosomal instability in epithelial cells.
  34. Yang W, Beaudoin E, Lu L, Du Pasquier R, Kuroda M, Willemsen R, et al. Chimeric immune receptors (CIRs) specific to JC virus for immunotherapy in progressive multifocal leukoencephalopathy (PML). Int Immunol. 2007;19:1083-93 pubmed
    ..In conclusion, anti-JCV designer T cells were generated...
  35. Suzuki T, Orba Y, Okada Y, Sunden Y, Kimura T, Tanaka S, et al. The human polyoma JC virus agnoprotein acts as a viroporin. PLoS Pathog. 2010;6:e1000801 pubmed publisher
    ..PML) is a fatal demyelinating disease resulting from lytic infection of oligodendrocytes by the polyomavirus JC virus (JCV). The genome of JCV encodes six major proteins including a small auxiliary protein known as agnoprotein...
  36. Rudick R, O Connor P, Polman C, Goodman A, Ray S, Griffith N, et al. Assessment of JC virus DNA in blood and urine from natalizumab-treated patients. Ann Neurol. 2010;68:304-10 pubmed publisher
    Analyses were conducted to determine the clinical utility of measuring JC virus (JCV) DNA in blood or urine of natalizumab-treated multiple sclerosis (MS) patients to predict the risk of progressive multifocal leukoencephalopathy (PML).
  37. Viscidi R, Khanna N, Tan C, Li X, Jacobson L, Clifford D, et al. JC virus antibody and viremia as predictors of progressive multifocal leukoencephalopathy in human immunodeficiency virus-1-infected individuals. Clin Infect Dis. 2011;53:711-5 pubmed publisher
    ..JCV viremia was not predictive of PML, but some patients showed higher anti-JCV immunoglobulin G (IgG) responses 6 months prior to diagnosis...
  38. Planas R, Jelcic I, Schippling S, Martin R, Sospedra M. Natalizumab treatment perturbs memory- and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis. Eur J Immunol. 2012;42:790-8 pubmed publisher
    ..been associated with the development of progressive multifocal leukoencephalopathy (PML), a disorder caused by JC virus (JCV) infection...
  39. Waterboer T, Dondog B, Michael K, Michel A, Schmitt M, Vaccarella S, et al. Dried blood spot samples for seroepidemiology of infections with human papillomaviruses, Helicobacter pylori, Hepatitis C Virus, and JC Virus. Cancer Epidemiol Biomarkers Prev. 2012;21:287-93 pubmed publisher
    ..To establish antibody analysis from dried blood spots (DBS) on filter paper for seroepidemiologic infection and cancer association studies, we analyzed data from a population-based study in Mongolia...
  40. Suzuki T, Semba S, Sunden Y, Orba Y, Kobayashi S, Nagashima K, et al. Role of JC virus agnoprotein in virion formation. Microbiol Immunol. 2012;56:639-46 pubmed publisher
    b>JC virus (JCV) belongs to the polyomavirus family of double-stranded DNA viruses and causes progressive multifocal leukoencephalopathy in humans...
  41. Mancuso R, Saresella M, Hernis A, Marventano I, Ricci C, Agostini S, et al. JC virus detection and JC virus-specific immunity in natalizumab-treated multiple sclerosis patients. J Transl Med. 2012;10:248 pubmed publisher
    The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML).
  42. Dugan A, GASPAROVIC M, Atwood W. Direct correlation between sialic acid binding and infection of cells by two human polyomaviruses (JC virus and BK virus). J Virol. 2008;82:2560-4 pubmed
    For the human polyomaviruses JC virus (JCV) and BK virus (BKV), the first step to a successful infection involves binding to sialic acid moieties located on the surfaces of host cells...
  43. Iacobaeus E, Ryschkewitsch C, Gravell M, Khademi M, Wallstrom E, Olsson T, et al. Analysis of cerebrospinal fluid and cerebrospinal fluid cells from patients with multiple sclerosis for detection of JC virus DNA. Mult Scler. 2009;15:28-35 pubmed publisher
    1) To determine whether JC virus (JCV) DNA was present in the cerebrospinal fluid (CSF) and blood from patients with multiple sclerosis (MS) in comparison with controls and 2) to find out if our clinical material, based on presence of JCV ..
  44. Stettner M, Nance J, Wright C, Kinoshita Y, Kim W, Morgello S, et al. SMAD proteins of oligodendroglial cells regulate transcription of JC virus early and late genes coordinately with the Tat protein of human immunodeficiency virus type 1. J Gen Virol. 2009;90:2005-14 pubmed publisher
    b>JC virus (JCV) is the aetiological agent of progressive multifocal leukoencephalopathy (PML), a fatal, demyelinating disease of the brain affecting people with AIDS...
  45. Tan C, Dezube B, Bhargava P, Autissier P, Wuthrich C, Miller J, et al. Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation. J Infect Dis. 2009;199:881-8 pubmed publisher
    We sought to determine the prevalence of JC virus (JCV) in bone marrow samples from human immunodeficiency virus (HIV)-positive and HIV-negative patients and to determine whether bone marrow is a site of latency and neurotropic ..
  46. Nukuzuma S, Nakamichi K, Nukuzuma C, Takegami T. Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells. Microbiol Immunol. 2009;53:496-501 pubmed publisher
    ..These results indicate that 5HT(2A)R antagonists have an inhibitory effect on JCV infection and reproduction, and JCI cells are applicable to an experimental model for pharmacological evaluation of antiviral agents against JCV...
  47. Comar M, Bonifacio D, Zanconati F, Di Napoli M, Isidoro E, Martini F, et al. High prevalence of BK polyomavirus sequences in human papillomavirus-16-positive precancerous cervical lesions. J Med Virol. 2011;83:1770-6 pubmed publisher
    ..Alternatively, BKV might multiply better in HPV-16-positive cells from precancerous cervical lesions than in HPV-16-negative cells...
  48. Lucchese G. Confronting JC virus and Homo sapiens biological signatures. Front Biosci (Landmark Ed). 2013;18:716-24 pubmed
    The present report describes the peptide commonality between JC virus (JCV) and the human proteome at the heptamer level...
  49. Costa C, Bergallo M, Sidoti F, Astegiano S, Terlizzi M, Mazzucco G, et al. Polyomaviruses BK- And JC-DNA quantitation in kidney allograft biopsies. J Clin Virol. 2009;44:20-3 pubmed publisher
    ..Polyomavirus-associated nephropathy (PVAN) is one of the most common viral disease affecting renal allograft, with BK being the most frequent causal agent and JCV being considered responsible in <3% of the cases...
  50. Jiang M, Abend J, Johnson S, Imperiale M. The role of polyomaviruses in human disease. Virology. 2009;384:266-73 pubmed publisher
    The human polyomaviruses, BK virus and JC virus, have long been associated with serious diseases including polyomavirus nephropathy and progressive multifocal leukoencephalopathy...
  51. Delbue S, Branchetti E, Bertolacci S, Tavazzi E, Marchioni E, Maserati R, et al. JC virus VP1 loop-specific polymorphisms are associated with favorable prognosis for progressive multifocal leukoencephalopathy. J Neurovirol. 2009;15:51-6 pubmed publisher
    b>JC virus (JCV) is a human polyomavirus that causes progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease that mainly affects immunocompromised subjects...
  52. Coelho T, Almeida L, Lazo P. JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process?. Virol J. 2010;7:42 pubmed publisher
    ..JCV transient effects might lead to selective expansion of tumor cells. Since there is not a direct cause and effect relationship, JCV infection may be an alternative to low frequency cancer predisposition genes...
  53. Weissert R. Progressive multifocal leukoencephalopathy. J Neuroimmunol. 2011;231:73-7 pubmed publisher
    ..PML) is a disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the opportunistic infections...
  54. Marshall L, Moore L, Mirsky M, Major E. JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytes. J Gen Virol. 2012;93:651-61 pubmed publisher
    b>JC virus (JCV) is the aetiological agent of the demyelinating disease progressive multifocal leukoencephalopathy, an AIDS defining illness and serious complication of mAb therapies. Initial infection probably occurs in childhood...
  55. Shishido Hara Y, Ichinose S, Uchihara T. JC virus intranuclear inclusions associated with PML-NBs: analysis by electron microscopy and structured illumination microscopy. Am J Pathol. 2012;180:1095-106 pubmed publisher
    Progressive multifocal leukoencephalopathy is a fatal demyelinating disorder caused by JC virus infection. JC virus was recently found to target promyelocytic leukemia nuclear bodies (PML-NBs), punctuate domains in the nuclei...
  56. Mou X, Chen L, Liu F, Lin J, Diao P, Wang H, et al. Prevalence of JC virus in Chinese patients with colorectal cancer. PLoS ONE. 2012;7:e35900 pubmed publisher
    ..Here, we investigated JCV infection and viral DNA load in Chinese CRC patients and to determine whether the JCV DNA in peripheral blood (PB) can be used as a diagnostic marker for JCV-related CRC...
  57. TAN C, Broge T, Seung E, Vrbanac V, Viscidi R, Gordon J, et al. Detection of JC virus-specific immune responses in a novel humanized mouse model. PLoS ONE. 2013;8:e64313 pubmed publisher
    Progressive Multifocal Leukoencephalopathy (PML) is an often fatal disease caused by the reactivation of the JC virus (JCV). Better understanding of viral-host interactions has been hampered by the lack of an animal model...
  58. Hirsch H, Kardas P, Kranz D, Leboeuf C. The human JC polyomavirus (JCPyV): virological background and clinical implications. APMIS. 2013;121:685-727 pubmed publisher
    ..Given the increasing number of immunologically vulnerable patients, a critical reappraisal of JCPyV infection, replication and disease seems warranted...
  59. Kobayashi S, Suzuki T, Igarashi M, Orba Y, Ohtake N, Nagakawa K, et al. Cysteine residues in the major capsid protein, Vp1, of the JC virus are important for protein stability and oligomer formation. PLoS ONE. 2013;8:e76668 pubmed publisher
    The capsid of the human polyomavirus JC virus (JCV) consists of 72 pentameric capsomeres of a major structural protein, Vp1...
  60. Sadiq S, Puccio L, Brydon E. JCV detection in multiple sclerosis patients treated with natalizumab. J Neurol. 2010;257:954-8 pubmed publisher
    ..Two hundred MS patients had pre-treatment CSF/plasma screening for JC virus (JCV) and BK virus (BKV) DNA, and thereafter every six treatments of natalizumab...
  61. Ksiaa F, Ziadi S, Mokni M, Korbi S, Trimeche M. The presence of JC virus in gastric carcinomas correlates with patient's age, intestinal histological type and aberrant methylation of tumor suppressor genes. Mod Pathol. 2010;23:522-30 pubmed publisher
    b>JC virus (JCV) is a neurotropic polyomavirus and the causative agent of progressive multifocal leukoencephalopathy. A role for JCV in gastrointestinal malignancies has been recently suggested...
  62. Bayliss J, Karasoulos T, Bowden S, Glogowski I, McLean C. Immunosuppression increases latent infection of brain by JC polyomavirus. Pathology. 2011;43:362-7 pubmed publisher
    ..Increased JCV reactivation in kidney, as indicated by JCV viruria is reported during immunosuppression; however, the relevance of systemic to neural reactivation remains unknown...
  63. Lin P, Fung C, Chang F, Huang W, Chen W, Wang J, et al. Prevalence and genotype identification of human JC virus in colon cancer in Taiwan. J Med Virol. 2008;80:1828-34 pubmed publisher
    Although JC virus (JCV), a human polyomavirus, has been detected in colon cancers, the association between JCV and colon cancer remains controversial...
  64. Chen L, Wang M, Ou W, Fung C, Chen P, Chang C, et al. Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model. Gene Ther. 2010;17:1033-41 pubmed publisher
    The JC virus (JCV) may infect human oligodendrocytes and consequently cause progressive multifocal leukoencephalopathy (PML) in patients with immune deficiency...
  65. Delbue S, Elia F, Carloni C, Tavazzi E, Marchioni E, Carluccio S, et al. JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy. J Cell Physiol. 2012;227:3511-7 pubmed publisher
    ..PML) is a severe disease of the central nervous system (CNS), caused by infection with the Polyomavirus JC virus (JCV)...
  66. Sariyer I, Khalili K, Safak M. Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: inhibition by small t antigen. Virology. 2008;375:464-79 pubmed publisher
    Previous studies have demonstrated that the JC virus (JCV) late regulatory protein agnoprotein is phosphorylated by the serine/threonine-specific protein kinase-C (PKC) and mutants of this protein at the PKC phosphorylation sites exhibit ..
  67. Chen Y, Bord E, Tompkins T, Miller J, Tan C, Kinkel R, et al. Asymptomatic reactivation of JC virus in patients treated with natalizumab. N Engl J Med. 2009;361:1067-74 pubmed publisher
    ..Most adults who are infected with the JC virus, the etiologic agent in PML, do not have symptoms...
  68. Boothpur R, Brennan D. Human polyoma viruses and disease with emphasis on clinical BK and JC. J Clin Virol. 2010;47:306-12 pubmed publisher
    ..There are five known human polyoma viruses. JC virus and BK virus are two polyoma viruses identified nearly three decades ago...
  69. Mengelle C, Kamar N, Mansuy J, Sandres Saune K, Legrand Abravanel F, Miedouge M, et al. JC virus DNA in the peripheral blood of renal transplant patients: a 1-year prospective follow-up in France. J Med Virol. 2011;83:132-6 pubmed publisher
    There is little information on JC virus (JCV) infection in renal transplant patients...
  70. Jiang Z, Cohen J, Marshall L, Major E. Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures. Antimicrob Agents Chemother. 2010;54:4723-32 pubmed publisher
    b>JC virus (JCV) is a polyomavirus that infects human oligodendrocytes, leading to development of progressive multifocal leukoencephalopathy (PML), an often fatal demyelinating disease occurring in immunocompromised individuals...
  71. Nukuzuma S, Nakamichi K, Kameoka M, Sugiura S, Nukuzuma C, Miyoshi I, et al. Efficient propagation of progressive multifocal leukoencephalopathy-type JC virus in COS-7-derived cell lines stably expressing Tat protein of human immunodeficiency virus type 1. Microbiol Immunol. 2010;54:758-62 pubmed publisher
    ..with many other immunosuppressive diseases suggests that HIV-1 infection is strictly related to the activation of JC virus (JCV) propagation...
  72. Mascarello M, Lanzafame M, Lattuada E, Concia E, Ferrari S. Progressive multifocal leukoencephalopathy in an HIV patient receiving successful long-term HAART. J Neurovirol. 2011;17:196-9 pubmed publisher
    ..The diagnosis of PML should always be considered in patients with consistent neurological symptoms, even with a high lymphocyte CD4+ level and a full viral suppression resulting from a long-term HAART...
  73. Mateen F, Muralidharan R, Carone M, van de Beek D, Harrison D, Aksamit A, et al. Progressive multifocal leukoencephalopathy in transplant recipients. Ann Neurol. 2011;70:305-22 pubmed publisher
    ..multifocal leukoencephalopathy (PML), a rare demyelinating disorder caused by oligodendrocyte destruction by JC virus. Reports of PML following transplantation were found using PubMed Entrez (1958-July 2010)...
  74. Alvarez Lafuente R, Garcia Montojo M, De las Heras V, Bartolome M, Arroyo R. JC virus in cerebrospinal fluid samples of multiple sclerosis patients at the first demyelinating event. Mult Scler. 2007;13:590-5 pubmed
    To evaluate the possible involvement of JC virus (JCV) in the aetiology of multiple sclerosis (MS), through the comparison of DNA prevalences and viral loads of JCV in cerebrospinal fluid (CSF) of MS patients at the first demyelinating ..
  75. Marzocchetti A, Sanguinetti M, Giambenedetto S, Cingolani A, Fadda G, Cauda R, et al. Characterization of JC virus in cerebrospinal fluid from HIV-1 infected patients with progressive multifocal leukoencephalopathy: insights into viral pathogenesis and disease prognosis. J Neurovirol. 2007;13:338-46 pubmed
    ..To analyze virological and immunological features of AIDS-related progressive multifocal leukoencepalophathy (PML) and their association to disease prognosis...
  76. Khalili K, Sariyer I, Safak M. Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation. J Cell Physiol. 2008;215:309-19 pubmed
    ..In this short review, we will focus on the structural and functional features of one polyomavirus transforming protein, that is, the small t-antigen of the human neurotropic JC virus (JCV) and the simian virus, SV40.
  77. Tan C, Ellis L, Wuthrich C, Ngo L, Broge T, Saint Aubyn J, et al. JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy. J Virol. 2010;84:9200-9 pubmed publisher
    b>JC virus (JCV) is latent in the kidneys and lymphoid organs of healthy individuals, and its reactivation in the context of immunosuppression may lead to progressive multifocal leukoencephalopathy (PML)...
  78. Wollebo H, Safak M, Del Valle L, Khalili K, White M. Role for tumor necrosis factor-? in JC virus reactivation and progressive multifocal leukoencephalopathy. J Neuroimmunol. 2011;233:46-53 pubmed publisher
    ..Immunohistochemistry of HIV+/PML revealed robust labeling for TNF-? and TNFR-1. These data suggest TNF-? stimulation of ?B may contribute to JCV reactivation in HIV+/PML...
  79. Sariyer I, Khalili K. Regulation of human neurotropic JC virus replication by alternative splicing factor SF2/ASF in glial cells. PLoS ONE. 2011;6:e14630 pubmed publisher
    The human neurotropic virus, JC virus (JCV), is the etiologic agent of the fatal demyelinating disease of the central nervous system, Progressive Multifocal Leukoencephalopathy (PML) that is seen primarily in immunodeficient individuals...
  80. Hu J, Zhao H, Huang Y, Zhang X, Gao H, Yang M, et al. Opportunistic posttransplantation virus infections in renal transplant recipients. Transplant Proc. 2011;43:3715-9 pubmed publisher
    ..In contrast, there is only limited information on JC virus (JCV) infection and its relation to CMV infection in RT recipients...
  81. Berger J, Khalili K. The pathogenesis of progressive multifocal leukoencephalopathy. Discov Med. 2011;12:495-503 pubmed
    ..Any hypothesis of PML pathogenesis must account for a number of facts. Firstly, the causative agent JC virus is ubiquitously present, yet only a vanishingly small number of infected persons develop the disease...
  82. Moll N, Rietsch A, Ransohoff A, Cossoy M, Huang D, Eichler F, et al. Cortical demyelination in PML and MS: Similarities and differences. Neurology. 2008;70:336-43 pubmed
    ..To characterize pathologic changes in the cerebral cortex of patients with multiple sclerosis (MS) and progressive multifocal leukoencephalopathy (PML)...
  83. Sidhu N, McCutchan J. Unmasking of PML by HAART: unusual clinical features and the role of IRIS. J Neuroimmunol. 2010;219:100-4 pubmed publisher
    ..Only 3 of the 8 patients with unmasked PML had IRIS reactions as evidenced by contrast enhancement around lesions on MRI, suggesting that IRIS is not necessary for the pathogenesis of this syndrome...
  84. Maginnis M, Haley S, Gee G, Atwood W. Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection. J Virol. 2010;84:9677-84 pubmed publisher
    b>JC virus (JCV) is a human polyomavirus and the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML)...
  85. Saundh B, Tibble S, Baker R, Sasnauskas K, Harris M, Hale A. Different patterns of BK and JC polyomavirus reactivation following renal transplantation. J Clin Pathol. 2010;63:714-8 pubmed publisher
    ..study was to determine reactivation patterns for these polyomaviruses in renal transplant recipients using an in-house quantitative real-time multiplex PCR assay and IgG serological assays using recombinant BK and JC virus-like particles.
  86. Ryschkewitsch C, Jensen P, Monaco M, Major E. JC virus persistence following progressive multifocal leukoencephalopathy in multiple sclerosis patients treated with natalizumab. Ann Neurol. 2010;68:384-91 pubmed publisher
    b>JC virus (JCV) DNA in the cerebrospinal fluid (CSF) provides the laboratory confirmatory diagnosis of progressive multifocal leukoencephalopathy (PML) in patients whose clinical symptoms and magnetic resonance imaging findings are ..
  87. Reviriego Mendoza M, Frisque R. Interaction and co-localization of JC virus large T antigen and the F-box protein ?-transducin-repeat containing protein. Virology. 2011;410:119-28 pubmed publisher
    Lytic infection and transformation of cultured cells by JC virus (JCV) require five tumor proteins, which interact with factors regulating critical cellular processes...
  88. Plavina T, Berman M, Njenga M, Crossman M, Lerner M, Gorelik L, et al. Multi-site analytical validation of an assay to detect anti-JCV antibodies in human serum and plasma. J Clin Virol. 2012;53:65-71 pubmed publisher
    b>JC virus (JCV) infection is a prerequisite for development of progressive multifocal leukoencephalopathy (PML)...
  89. Kitchen A, Miyamoto M, Mulligan C. Utility of DNA viruses for studying human host history: case study of JC virus. Mol Phylogenet Evol. 2008;46:673-82 pubmed
    ..Here, we assess the utility of a well known DNA virus, JC virus (JCV), for investigating human history and demography...
  90. Boldorini R, Veggiani C, Amoruso E, Allegrini S, Miglio U, Paganotti A, et al. Latent human polyomavirus infection in pregnancy: investigation of possible transplacental transmission. Pathology. 2008;40:72-7 pubmed
    ..The purpose of the study was to investigate the transplacental transmission of the human polyomaviruses JCV and BKV...
  91. Wang Y, Kirby J, Qian Q. Effective use of JC virus PCR for diagnosis of progressive multifocal leukoencephalopathy. J Med Microbiol. 2009;58:253-5 pubmed publisher
    ..of data from 168 patients with suspected progressive multifocal leukoencephalopathy (PML) between 1996 and 2006, JC virus (JCV) PCR on cerebrospinal fluid (CSF) samples was positive only in human immunodeficiency virus (HIV)-infected ..
  92. Comar M, Zanotta N, Bovenzi M, Campello C. JCV/BKV and SV40 viral load in lymphoid tissues of young immunocompetent children from an area of north-east Italy. J Med Virol. 2010;82:1236-40 pubmed publisher
    ..Nevertheless, the low prevalence of polyomavirus, in comparison with the lymphotropic HHV-6, suggests that these tissues are unlikely to be the preferred site of polyomavirus latency, at least in younger children...