polyomavirus

Summary

Summary: A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.

Top Publications

  1. Bofill Mas S, Rodriguez Manzano J, Calgua B, Carratala A, Girones R. Newly described human polyomaviruses Merkel cell, KI and WU are present in urban sewage and may represent potential environmental contaminants. Virol J. 2010;7:141 pubmed publisher
    Recently, three new polyomaviruses (KI, WU and Merkel cell polyomavirus) have been reported to infect humans. It has also been suggested that lymphotropic polyomavirus, a virus of simian origin, infects humans...
  2. Sharp C, Norja P, Anthony I, Bell J, Simmonds P. Reactivation and mutation of newly discovered WU, KI, and Merkel cell carcinoma polyomaviruses in immunosuppressed individuals. J Infect Dis. 2009;199:398-404 pubmed publisher
    ..we investigated whether the recently discovered WU and KI polyomaviruses (WUPyV and KIPyV) and Merkel cell polyomavirus (MCPyV) could, like BKV and JCV, persist, mutate, and reactivate in immunodeficient subjects...
  3. Al Daraji W, Anandan A, Klassen Fischer M, Auerbach A, Marwaha J, Fanburg Smith J. Soft tissue Rosai-Dorfman disease: 29 new lesions in 18 patients, with detection of polyomavirus antigen in 3 abdominal cases. Ann Diagn Pathol. 2010;14:309-16 pubmed publisher
    ..Simian virus 40 (SV40), a polyomavirus, has been identified in lymphoid processes and has a controversial role in neoplasia etiology...
  4. Chen T, Mattila P, Jartti T, Ruuskanen O, Soderlund Venermo M, Hedman K. Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus. J Infect Dis. 2011;204:1523-6 pubmed publisher
    Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions...
  5. Kassem A, Technau K, Kurz A, Pantulu D, Löning M, Kayser G, et al. Merkel cell polyomavirus sequences are frequently detected in nonmelanoma skin cancer of immunosuppressed patients. Int J Cancer. 2009;125:356-61 pubmed publisher
    ..How MCPyV contributes to the pathogenesis of NMSC, i.e., BD, SCC and BCC, in immunosuppressed patients and in addition, potentially to the pathogenesis of a subset of sporadic BCC needs further investigations. ..
  6. Schmitt M, Höfler D, Koleganova N, Pawlita M. Human polyomaviruses and other human viruses in neuroendocrine tumors. Cancer Epidemiol Biomarkers Prev. 2011;20:1558-61 pubmed publisher
    While the association of the Merkel cell polyomavirus (MCV) with the neuroendocrine Merkel cell carcinomas (MCC) has been shown recently, it is unknown whether other human polyomaviruses (HPyV) may be associated with neuroendocrine ..
  7. Scuda N, Hofmann J, Calvignac Spencer S, Ruprecht K, Liman P, K hn J, et al. A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus. J Virol. 2011;85:4586-90 pubmed publisher
    We identified a novel human polyomavirus from a kidney transplant patient under immunosuppressive treatment, by use of a generic PCR. The genome of the virus was completely amplified and sequenced...
  8. Sauvage V, Foulongne V, Cheval J, Ar Gouilh M, Pariente K, Dereure O, et al. Human polyomavirus related to African green monkey lymphotropic polyomavirus. Emerg Infect Dis. 2011;17:1364-70 pubmed publisher
    ..patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion ..
  9. Abedi Kiasari B, Vallely P, Corless C, Al Hammadi M, Klapper P. Age-related pattern of KI and WU polyomavirus infection. J Clin Virol. 2008;43:123-5 pubmed publisher
    ..The age distribution of KIV and WUV infection in this study mirrors that found for the other human polyomaviruses, BK and JC. ..

More Information

Publications103 found, 100 shown here

  1. Wu K, McCue P, Berger A, Spiegel J, Wang Z, Witkiewicz A. Detection of Merkel cell carcinoma polyomavirus in mucosal Merkel cell carcinoma. Int J Surg Pathol. 2010;18:342-6 pubmed publisher
    ..MCC was recently shown to harbor a novel polyomavirus, Merkel cell polyomavirus (MCPyV), in the majority of cases...
  2. Chen T, Hedman L, Mattila P, Jartti T, Ruuskanen O, Soderlund Venermo M, et al. Serological evidence of Merkel cell polyomavirus primary infections in childhood. J Clin Virol. 2011;50:125-9 pubmed publisher
    Merkel cell polyomavirus (MCPyV) was identified newly (2008) and is believed to be an etiologic factor of Merkel cell carcinoma (MCC). Recent molecular and serological data suggest that MCPyV infection is common in the general population...
  3. Yuan X, Xu Z, Xie Z, Gao H, Zhang R, Song J, et al. [WU polyomavirus and KI polyomavirus detected in specimens from children with acute respiratory tract infection in China]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008;22:21-3 pubmed
    To investigate newly identified polyomavirus WUV and WUV and KIPyV are associated with acute respiratory infections in China, tests were developed to detect WUV and KIPyV gene fragments from nasopharyngeal aspirates collected from ..
  4. Shuda M, Feng H, Kwun H, Rosen S, Gjoerup O, Moore P, et al. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A. 2008;105:16272-7 pubmed publisher
    Merkel cell polyomavirus (MCV) is a virus discovered in our laboratory at the University of Pittsburgh that is monoclonally integrated into the genome of approximately 80% of human Merkel cell carcinomas (MCCs)...
  5. Andres C, Puchta U, Sander C, Ruzicka T, Flaig M. Prevalence of Merkel cell polyomavirus DNA in cutaneous lymphomas, pseudolymphomas, and inflammatory skin diseases. Am J Dermatopathol. 2010;32:593-8 pubmed publisher
    Several groups confirmed Merkel cell polyomavirus (MCPyV) as the likely causative agent of Merkel cell carcinoma. Hematolymphoid disorders are known to be a substantial risk factor for Merkel cell carcinoma, and vice versa...
  6. Nicol J, Robinot R, Carpentier A, Carandina G, Mazzoni E, Tognon M, et al. Age-specific seroprevalences of merkel cell polyomavirus, human polyomaviruses 6, 7, and 9, and trichodysplasia spinulosa-associated polyomavirus. Clin Vaccine Immunol. 2013;20:363-8 pubmed publisher
    Six new human polyomaviruses have been identified since 2008 (Merkel cell polyomavirus [MCPyV], human polyomavirus 6 [HPyV6], HPyV7, HPyV9, trichodysplasia spinulosa polyomavirus [TSPyV], and Malawi polyomavirus [MWPyV])...
  7. Han T, Chung J, Koo J, Kim S, Hwang E. WU polyomavirus in children with acute lower respiratory tract infections, South Korea. Emerg Infect Dis. 2007;13:1766-8 pubmed publisher
    In South Korea, WU polyomavirus (WUPyV) was detected in 34 (7%) of 486 children with acute lower respiratory tract infections, 3 (4.2%) of 72 asymptomatic children, and as coinfection with other respiratory viruses in 23 (67.6%) children...
  8. Walczak C, Tsai B. A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection. J Virol. 2011;85:2386-96 pubmed publisher
    Endoplasmic reticulum (ER)-to-cytosol membrane transport is a decisive infection step for the murine polyomavirus (Py)...
  9. Jiang M, Abend J, Johnson S, Imperiale M. The role of polyomaviruses in human disease. Virology. 2009;384:266-73 pubmed publisher
    The human polyomaviruses, BK virus and JC virus, have long been associated with serious diseases including polyomavirus nephropathy and progressive multifocal leukoencephalopathy...
  10. Randhawa P, Viscidi R, Carter J, Galloway D, Culp T, Huang C, et al. Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodies. J Gen Virol. 2009;90:634-9 pubmed publisher
    The human antibody response to polyomavirus capsid proteins is not well characterized...
  11. Busam K, Jungbluth A, Rekthman N, Coit D, Pulitzer M, Bini J, et al. Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. Am J Surg Pathol. 2009;33:1378-85 pubmed publisher
    ..We examined the presence of Merkel cell polyomavirus (MCV) in a set of 17 frozen tumor samples by quantitative polymerase chain reaction; 15 of them (88%) were ..
  12. Kuypers J, Campbell A, Guthrie K, Wright N, Englund J, Corey L, et al. WU and KI polyomaviruses in respiratory samples from allogeneic hematopoietic cell transplant recipients. Emerg Infect Dis. 2012;18:1580-8 pubmed publisher
    Data are limited regarding 2 new human polyomaviruses, KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV), in immunocompromised patients...
  13. Vanchiere J, Abudayyeh S, Copeland C, Lu L, Graham D, Butel J. Polyomavirus shedding in the stool of healthy adults. J Clin Microbiol. 2009;47:2388-91 pubmed publisher
    ..In order to determine if adults exhibit fecal shedding of polyomavirus, single stool specimens from healthy adults were evaluated by PCR. Overall, 20 (18...
  14. Lintas C, Altieri L, Lombardi F, Sacco R, Persico A. Association of autism with polyomavirus infection in postmortem brains. J Neurovirol. 2010;16:141-9 pubmed publisher
    ..7%, respectively; P = .08). Follow-up studies exploring vertical viral transmission as a possible pathogenetic mechanism in autistic disorder should focus on, but not be limited to, the role of polyomaviruses. ..
  15. Kean J, Rao S, Wang M, Garcea R. Seroepidemiology of human polyomaviruses. PLoS Pathog. 2009;5:e1000363 pubmed publisher
    ..The seroprevalence in children under 21 years of age (n = 721) for all Pys was similar to that of the adult population, suggesting that primary exposure to these viruses likely occurs in childhood. ..
  16. Bhatia K, Modali R, Goedert J. Merkel cell polyomavirus is not detected in mesotheliomas. J Clin Virol. 2010;47:196-8 pubmed publisher
    Merkel cell polyomavirus (MCPyV) is the first polyoma virus consistently linked to the etiology of a human cancer...
  17. McClure G, Gardner J, Williams J, Copeland C, Sylvester S, Garcea R, et al. Dynamics of pregnancy-associated polyomavirus urinary excretion: a prospective longitudinal study. J Med Virol. 2012;84:1312-22 pubmed publisher
    ..has been documented in point prevalence studies, but little attention has been given to the dynamics of polyomavirus excretion during pregnancy because of its benign course...
  18. van der Zalm M, Rossen J, van Ewijk B, Wilbrink B, van Esch P, Wolfs T, et al. Prevalence and pathogenicity of WU and KI polyomaviruses in children, the Netherlands. Emerg Infect Dis. 2008;14:1787-9 pubmed publisher
    ..In some children both viruses were detected for long periods. In several symptomatic children no other respiratory pathogen was detected. ..
  19. Seo G, Chen C, Sullivan C. Merkel cell polyomavirus encodes a microRNA with the ability to autoregulate viral gene expression. Virology. 2009;383:183-7 pubmed publisher
    ..We show that Merkel Cell Polyomavirus (MCV), a recently identified human virus associated with cancer, encodes a miRNA...
  20. Tolstov Y, Pastrana D, Feng H, Becker J, Jenkins F, Moschos S, et al. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer. 2009;125:1250-6 pubmed publisher
    Merkel cell polyomavirus (MCV) is a newly-discovered human tumor virus found in approximately 80% of Merkel cell carcinoma (MCC). The rate of MCV infection among persons without MCC is unknown...
  21. Babakir Mina M, Ciccozzi M, Lo Presti A, Greco F, Perno C, Ciotti M. Identification of Merkel cell polyomavirus in the lower respiratory tract of Italian patients. J Med Virol. 2010;82:505-9 pubmed publisher
    Merkel cell polyomavirus (MCPyV) has been found to be integrated monoclonally in a rare skin cancer named Merkel cell carcinoma. More recently, MCPyV has been detected in the upper respiratory tract of pediatric and adult patients...
  22. Garneski K, Warcola A, Feng Q, Kiviat N, Leonard J, Nghiem P. Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol. 2009;129:246-8 pubmed publisher
  23. Babakir Mina M, Ciccozzi M, Campitelli L, Aquaro S, Lo Coco A, Perno C, et al. Identification of the novel KI Polyomavirus in paranasal and lung tissues. J Med Virol. 2009;81:558-61 pubmed publisher
    KI is a novel polyomavirus identified in the respiratory secretions of children with acute respiratory symptoms. Whether this reflects a causal role of the virus in the human respiratory disease remains to be established...
  24. Schowalter R, Pastrana D, Pumphrey K, Moyer A, Buck C. Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe. 2010;7:509-15 pubmed publisher
    Mounting evidence indicates that Merkel cell polyomavirus (MCV), a circular double-stranded DNA virus, is a causal factor underlying a highly lethal form of skin cancer known as Merkel cell carcinoma...
  25. Kazem S, van der Meijden E, Feltkamp M. The trichodysplasia spinulosa-associated polyomavirus: virological background and clinical implications. APMIS. 2013;121:770-82 pubmed publisher
    Trichodysplasia spinulosa-associated polyomavirus (TSPyV) is a new species of the family Polyomaviridae that was discovered in 2010...
  26. Misra V, Dumonceaux T, Dubois J, Willis C, Nadin Davis S, Severini A, et al. Detection of polyoma and corona viruses in bats of Canada. J Gen Virol. 2009;90:2015-22 pubmed publisher
    ..We detected RNA of a group 1 coronavirus from M. lucifugus (3 of 31 animals) and DNA from an as-yet undescribed polyomavirus from female M. lucifugus (4 of 31 animals) and M. californicus (pooled tissues from two females).
  27. Gjoerup O, Chang Y. Update on human polyomaviruses and cancer. Adv Cancer Res. 2010;106:1-51 pubmed publisher
    Over 50 years of polyomavirus research has produced a wealth of insights into not only general biologic processes in mammalian cells, but also, how conditions can be altered and signaling systems tweaked to produce transformation ..
  28. Halami M, Dorrestein G, Couteel P, Heckel G, Muller H, Johne R. Whole-genome characterization of a novel polyomavirus detected in fatally diseased canary birds. J Gen Virol. 2010;91:3016-22 pubmed publisher
    ..Using broad-spectrum PCR, a novel polyomavirus, tentatively designated canary polyomavirus (CaPyV), was detected in diseased canary birds (Serinus canaria) ..
  29. Deuzing I, Fagrouch Z, Groenewoud M, Niphuis H, Kondova I, Bogers W, et al. Detection and characterization of two chimpanzee polyomavirus genotypes from different subspecies. Virol J. 2010;7:347 pubmed publisher
    The complete nucleotide sequences of three chimpanzee polyomavirus genetic variants were determined. Phylogenetic analysis indicated that the viruses form two different genotypes of ChPyV...
  30. Siebrasse E, Reyes A, Lim E, Zhao G, Mkakosya R, Manary M, et al. Identification of MW polyomavirus, a novel polyomavirus in human stool. J Virol. 2012;86:10321-6 pubmed publisher
    We have discovered a novel polyomavirus present in multiple human stool samples...
  31. Buck C, Phan G, Raiji M, Murphy P, McDermott D, McBride A. Complete genome sequence of a tenth human polyomavirus. J Virol. 2012;86:10887 pubmed publisher
    Nine polyomavirus (PyV) species are known to productively infect humans. The circular DNA genomes of PyVs are readily detectable using rolling circle amplification (RCA)...
  32. Cheng J, DeCaprio J, Fluck M, Schaffhausen B. Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens. Semin Cancer Biol. 2009;19:218-28 pubmed publisher
    ..The unique contributions of SV40 LT and ST and PY MT to cellular transformation have provided significant insights into our understanding of tumor suppressors, oncogenes and the process of oncogenesis. ..
  33. Mertz K, Junt T, Schmid M, Pfaltz M, Kempf W. Inflammatory monocytes are a reservoir for Merkel cell polyomavirus. J Invest Dermatol. 2010;130:1146-51 pubmed publisher
    Merkel cell polyomavirus (MCPyV) is a recently discovered virus that is implicated in the oncogenesis of Merkel cell carcinoma (MCC)...
  34. Lin F, Zheng M, Li H, Zheng C, Li X, Rao G, et al. WU polyomavirus in children with acute lower respiratory tract infections, China. J Clin Virol. 2008;42:94-102 pubmed publisher
    WU polyomavirus (WUPyV), a new member of the genus of Polyomavirus in the family Polyomaviridae, has been found and associated with respiratory tract infections recently. However, its clinical role and pathogenicity has not been known.
  35. Howley P, Livingston D. Small DNA tumor viruses: large contributors to biomedical sciences. Virology. 2009;384:256-9 pubmed publisher
    ..In this article we examine the many contributions that have come from the small DNA tumor virus field and provide a recounting of some of the major landmark discoveries...
  36. Bergallo M, Terlizzi M, Astegiano S, Ciotti M, Babakir Mina M, Perno C, et al. Real time PCR TaqMan assays for detection of polyomaviruses KIV and WUV in clinical samples. J Virol Methods. 2009;162:69-74 pubmed publisher
    ..The choice of the primer/probe set, and primarily of the region for amplification, may be relevant for understanding the pathogenic role of viruses such as polyomaviruses KI and WU...
  37. Pastrana D, Pumphrey K, Cuburu N, Schowalter R, Buck C. Characterization of monoclonal antibodies specific for the Merkel cell polyomavirus capsid. Virology. 2010;405:20-5 pubmed publisher
    Merkel cell polyomavirus (MCV) has been implicated as a causative agent in Merkel cell carcinoma...
  38. Mertz K, Pfaltz M, Junt T, Schmid M, Fernandez Figueras M, Pfaltz K, et al. Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin. Hum Pathol. 2010;41:1369-79 pubmed publisher
    ..We sought to determine the prevalence of Merkel cell polyomavirus in benign epithelial skin neoplasms and nonmelanoma skin cancer of immunosuppressed renal transplant recipients ..
  39. van der Meijden E, Janssens R, Lauber C, Bouwes Bavinck J, Gorbalenya A, Feltkamp M. Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. PLoS Pathog. 2010;6:e1001024 pubmed publisher
    ..Here we report the identification of a new human polyomavirus in plucked facial spines of a heart transplant patient with trichodysplasia spinulosa, a rare skin disease ..
  40. Erickson K, Bouchet Marquis C, Heiser K, Szomolanyi Tsuda E, Mishra R, Lamothe B, et al. Virion assembly factories in the nucleus of polyomavirus-infected cells. PLoS Pathog. 2012;8:e1002630 pubmed publisher
    ..Electron microscopy on freeze-substituted, plastic-embedded sections of murine polyomavirus (PyV)-infected 3T3 mouse fibroblasts or mouse embryonic fibroblasts (MEFs) revealed tubular structures in the ..
  41. Yamaguchi H, Kobayashi S, Ishii A, Ogawa H, Nakamura I, Moonga L, et al. Identification of a novel polyomavirus from vervet monkeys in Zambia. J Gen Virol. 2013;94:1357-64 pubmed publisher
    To examine polyomavirus (PyV) infection in wildlife, we investigated the presence of PyVs in Zambia with permission from the Zambia Wildlife Authority...
  42. Garneski K, DeCaprio J, Nghiem P. Does a new polyomavirus contribute to Merkel cell carcinoma?. Genome Biol. 2008;9:228 pubmed publisher
    ..Here we examine what it will take to determine whether or not this virus contributes to carcinogenesis...
  43. Schaffhausen B, Roberts T. Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology. 2009;384:304-16 pubmed publisher
    Middle T antigen (MT) is the principal oncogene of murine polyomavirus. Its study has led to the discovery of the roles of tyrosine kinase and phosphoinositide 3-kinase (PI3K) signaling in mammalian growth control and transformation...
  44. Becker J, Schrama D, Houben R. Merkel cell carcinoma. Cell Mol Life Sci. 2009;66:1-8 pubmed publisher
    ..Most important, and possibly with high impact on future therapeutic approaches is the demonstration that a polyomavirus has frequently integrated in the genome of the MCC cells prior to tumor development.
  45. Neske F, Blessing K, Pröttel A, Ullrich F, Kreth H, Weissbrich B. Detection of WU polyomavirus DNA by real-time PCR in nasopharyngeal aspirates, serum, and stool samples. J Clin Virol. 2009;44:115-8 pubmed publisher
    The human WU polyomavirus (WUPyV) has been recently described as a novel virus in respiratory tract samples.
  46. Sastre Garau X, Peter M, Avril M, Laude H, Couturier J, Rozenberg F, et al. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J Pathol. 2009;218:48-56 pubmed publisher
    ..MCC), a skin tumour with neuroendocrine features, was recently found to be associated with a new type of human polyomavirus, called Merkel cell virus (MCV)...
  47. Dworkin A, Tseng S, Allain D, Iwenofu O, Peters S, Toland A. Merkel cell polyomavirus in cutaneous squamous cell carcinoma of immunocompetent individuals. J Invest Dermatol. 2009;129:2868-74 pubmed publisher
    ..Recently, a newly described polyoma virus, Merkel cell polyomavirus (MCPyV), was found in Merkel cell carcinoma (MCC), a rare aggressive skin cancer also associated with ..
  48. Babakir Mina M, Ciccozzi M, Bonifacio D, Bergallo M, Costa C, Cavallo R, et al. Identification of the novel KI and WU polyomaviruses in human tonsils. J Clin Virol. 2009;46:75-9 pubmed publisher
    ..Three novel polyomaviruses have been recently discovered: KI, WU and MC polyomaviruses. Their role in human pathology is debated while tissue tropism and site of latency remain unknown...
  49. Houben R, Shuda M, Weinkam R, Schrama D, Feng H, Chang Y, et al. Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol. 2010;84:7064-72 pubmed publisher
    ..Recently, it was demonstrated that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors...
  50. Nims R, Plavsic M. Polyomavirus inactivation - a review. Biologicals. 2013;41:63-70 pubmed publisher
    b>Polyomavirus inactivation has been studied since the 1950s when it became apparent that certain polio vaccines were contaminated with SV40...
  51. Feng H, Shuda M, Chang Y, Moore P. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319:1096-100 pubmed publisher
    ..investigation led to identification and sequence analysis of the 5387-base-pair genome of a previously unknown polyomavirus that we call Merkel cell polyomavirus (MCV or MCPyV)...
  52. Andreasson K, Tegerstedt K, Eriksson M, Curcio C, Cavallo F, Forni G, et al. Murine pneumotropic virus chimeric Her2/neu virus-like particles as prophylactic and therapeutic vaccines against Her2/neu expressing tumors. Int J Cancer. 2009;124:150-6 pubmed publisher
    ..Previously, we have immunized with murine polyomavirus (MPyV) VLPs carrying human Her2/neu and prevented the outgrowth of a human Her2/neu expressing tumor in a ..
  53. Bialasiewicz S, Whiley D, Lambert S, Nissen M, Sloots T. Detection of BK, JC, WU, or KI polyomaviruses in faecal, urine, blood, cerebrospinal fluid and respiratory samples. J Clin Virol. 2009;45:249-54 pubmed publisher
    ..The related human polyomaviruses JCV and BKV in contrast, have been detected in a wide range of sample types, leading to increased knowledge about their biology and pathogenesis...
  54. Barzon L, Squarzon L, Militello V, Trevisan M, Porzionato A, Macchi V, et al. WU and KI polyomaviruses in the brains of HIV-positive patients with and without progressive multifocal leukoencephalopathy. J Infect Dis. 2009;200:1755-8 pubmed publisher
    ..No specific histopathological findings were found to be associated with the presence of WUPyV and KIPyV...
  55. Mishra R, Chen A, Welsh R, Szomolanyi Tsuda E. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog. 2010;6:e1000924 pubmed publisher
    ..b>Polyomavirus (PyV) induces tumors in neonatally infected mice of susceptible strains and in adult mice with certain immune ..
  56. Kuwamoto S, Higaki H, Kanai K, Iwasaki T, Sano H, Nagata K, et al. Association of Merkel cell polyomavirus infection with morphologic differences in Merkel cell carcinoma. Hum Pathol. 2011;42:632-40 pubmed publisher
    Recently, it has been shown that approximately 80% of Merkel cell carcinomas harbor a novel polyomavirus named Merkel cell polyomavirus, thought to be a carcinogenic agent...
  57. Trusch F, Klein M, Finsterbusch T, Kuhn J, Hofmann J, Ehlers B. Seroprevalence of human polyomavirus 9 and cross-reactivity to African green monkey-derived lymphotropic polyomavirus. J Gen Virol. 2012;93:698-705 pubmed publisher
    Human polyomavirus 9 (HPyV9) was discovered recently in immunocompromised patients and shown to be genetically closely related to B-lymphotropic polyomavirus (LPyV)...
  58. Bialasiewicz S, Whiley D, Lambert S, Wang D, Nissen M, Sloots T. A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children. J Clin Virol. 2007;40:15-8 pubmed
    Recently, Allander and co-workers reported the discovery of a new human polyomavirus, KI virus, in respiratory secretions from patients with acute respiratory tract infection (ARTI).
  59. Bialasiewicz S, Whiley D, Lambert S, Jacob K, Bletchly C, Wang D, et al. Presence of the newly discovered human polyomaviruses KI and WU in Australian patients with acute respiratory tract infection. J Clin Virol. 2008;41:63-8 pubmed
    ..Currently, the role of the novel human polyomaviruses, KI (KIV) and WU (WUV) as agents of human disease remains uncertain...
  60. zur Hausen H. Novel human polyomaviruses--re-emergence of a well known virus family as possible human carcinogens. Int J Cancer. 2008;123:247-250 pubmed publisher
    ..The rhesus monkey virus SV40 and mouse polyomavirus have been studied in particular detail...
  61. Rainey Barger E, Mkrtchian S, Tsai B. The C-terminal domain of ERp29 mediates polyomavirus binding, unfolding, and infection. J Virol. 2009;83:1483-91 pubmed publisher
    Penetration of the endoplasmic reticulum (ER) membrane by polyomavirus (PyV) is a decisive step in virus entry...
  62. Koljonen V, Kukko H, Pukkala E, Sankila R, Bohling T, Tukiainen E, et al. Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma. Br J Cancer. 2009;101:1444-7 pubmed publisher
    Immunosuppression and Merkel-cell polyomavirus (MCPyV) infection may have a role in the pathogenesis of Merkel-cell carcinoma (MCC), a rare neuroendocrine carcinoma of the skin.
  63. Wieland U, Mauch C, Kreuter A, Krieg T, Pfister H. Merkel cell polyomavirus DNA in persons without merkel cell carcinoma. Emerg Infect Dis. 2009;15:1496-8 pubmed publisher
    Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors...
  64. Hruskova V, Moravkova A, Babiarová K, Ludvikova V, Fric J, Vonka V, et al. Bcr-Abl fusion sequences do not induce immune responses in mice when administered in mouse polyomavirus based virus-like particles. Int J Oncol. 2009;35:1247-56 pubmed
    Mouse polyomavirus-like particles (MPyV-VLPs) carrying inside a fragment of the Bcr-Abl hybrid protein containing the epitope of chronic myeloid leukemia fusion region were prepared...
  65. Debiaggi M, Canducci F, Brerra R, Sampaolo M, Marinozzi M, Parea M, et al. Molecular epidemiology of KI and WU polyomaviruses in infants with acute respiratory disease and in adult hematopoietic stem cell transplant recipients. J Med Virol. 2010;82:153-6 pubmed publisher
    ..4%) and 1 for KIPyV (0.2%). Single polyomavirus infection was detected in four patients, whereas the remaining patients were co-infected with respiratory ..
  66. Kantola K, Sadeghi M, Ewald M, Weissbrich B, Allander T, Lindau C, et al. Expression and serological characterization of polyomavirus WUPyV and KIPyV structural proteins. Viral Immunol. 2010;23:385-93 pubmed publisher
    ..The high and rapidly increasing IgG prevalence rates observed in this study for WUPyV and KIPyV support the notion that these novel polyomaviruses are widespread and are acquired early in childhood...
  67. Bialasiewicz S, Lambert S, Whiley D, Nissen M, Sloots T. Merkel cell polyomavirus DNA in respiratory specimens from children and adults. Emerg Infect Dis. 2009;15:492-4 pubmed publisher
    Merkel cell polyomavirus (MCPyV) DNA was detected in 7 (1.3%) of 526 respiratory tract samples from patients in Australia with upper or lower respiratory tract symptoms...
  68. Kantola K, Sadeghi M, Lahtinen A, Koskenvuo M, Aaltonen L, Möttönen M, et al. Merkel cell polyomavirus DNA in tumor-free tonsillar tissues and upper respiratory tract samples: implications for respiratory transmission and latency. J Clin Virol. 2009;45:292-5 pubmed publisher
    Merkel cell polyomavirus (MCPyV) was discovered recently. It is considered a potential causative agent of Merkel cell carcinoma, a life-threatening skin cancer.
  69. Touze A, Gaitan J, Maruani A, Le Bidre E, Doussinaud A, Clavel C, et al. Merkel cell polyomavirus strains in patients with merkel cell carcinoma. Emerg Infect Dis. 2009;15:960-2 pubmed publisher
    We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations...
  70. Fischer N, Brandner J, Fuchs F, Moll I, Grundhoff A. Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology and growth phenotype do not reflect presence of the virus. Int J Cancer. 2010;126:2133-42 pubmed publisher
    The recently discovered human polyomavirus (MCPyV) is frequently found in Merkel cell carcinoma (MCC) tissue and is believed to be causally linked to MCC pathogenesis...
  71. Hormozdi D, Arens M, Le B, Buller R, Agapov E, Storch G. KI polyomavirus detected in respiratory tract specimens from patients in St. Louis, Missouri. Pediatr Infect Dis J. 2010;29:329-33 pubmed publisher
    Studies have reported the presence of KI polyomavirus (KIPyV) and WU polyomavirus (WUPyV) in respiratory secretions of young patients...
  72. Carroll J, Dey D, Kreisman L, Velupillai P, Dahl J, Telford S, et al. Receptor-binding and oncogenic properties of polyoma viruses isolated from feral mice. PLoS Pathog. 2007;3:e179 pubmed
    ..Conservation of these receptor-binding properties under natural selection preserves the oncogenic potential of the virus. These findings emphasize the importance of immune protection of neonates under conditions of natural transmission...
  73. Lin F, Zheng M, Li H, Zheng C, Rao G, Zheng M, et al. [Discovery and identification of WU polyomavirus in children from Zhejing region]. Bing Du Xue Bao. 2008;24:69-71 pubmed
    WU polyomavirus, which was firstly discovered in 2007, is a new human polyomavirus belonging to Polyomaviridae and containing circular double-stranded genomic DNA...
  74. Bhatia K, Goedert J, Modali R, Preiss L, Ayers L. Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression. Int J Cancer. 2010;126:2240-6 pubmed publisher
    Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC), a clinically and pathologically heterogeneous malignancy of dermal neuroendocrine cells...
  75. Katano H, Ito H, Suzuki Y, Nakamura T, Sato Y, Tsuji T, et al. Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma. J Med Virol. 2009;81:1951-8 pubmed publisher
    ..Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma...
  76. Huerfano S, Zila V, Boura E, Spanielová H, Stokrova J, Forstova J. Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection. FEBS J. 2010;277:1270-83 pubmed publisher
    Minor structural proteins of mouse polyomavirus (MPyV) are essential for virus infection...
  77. Waltari M, Sihto H, Kukko H, Koljonen V, Sankila R, Bohling T, et al. Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma. Int J Cancer. 2011;129:619-28 pubmed publisher
    Most Merkel cell carcinomas (MCCs) contain Merkel cell polyomavirus (MCPyV) DNA, and the virus likely has a pivotal role in tumor pathogenesis...
  78. Pancaldi C, Corazzari V, Maniero S, Mazzoni E, Comar M, Martini F, et al. Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors. Blood. 2011;117:7099-101 pubmed publisher
    Merkel cell polyomavirus (MCPyV), a DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia. MCPyV sequences have also been detected in various normal tissues in tumor-affected patients...
  79. Zhuang W, Lu X, Lin G, Wu Y, Lin C, Chen P, et al. WU polyomavirus infection among children in South China. J Med Virol. 2011;83:1440-5 pubmed publisher
    ..aimed at investigating the prevalence and clinical characteristics of children with respiratory infection by WU polyomavirus (WUPyV) in Southern China...
  80. Corallini A, Mazzoni E, Taronna A, Manfrini M, Carandina G, Guerra G, et al. Specific antibodies reacting with simian virus 40 capsid protein mimotopes in serum samples from healthy blood donors. Hum Immunol. 2012;73:502-10 pubmed publisher
    ..These data suggest that SV40, or a yet undetected closely related polyomavirus, is circulating in human populations, but with lower prevalence than that of the ubiquitous BK and JC human ..
  81. Kemball C, Pack C, Guay H, Li Z, Steinhauer D, Szomolanyi Tsuda E, et al. The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. J Immunol. 2007;179:1113-21 pubmed
    ..In summary, these studies show that CD4(+) T cells differentially affect CD8(+) T cell responses over the course of a persistent virus infection...
  82. Osswald S, Kulick K, Tomaszewski M, Sperling L. Viral-associated trichodysplasia in a patient with lymphoma: a case report and review. J Cutan Pathol. 2007;34:721-5 pubmed
    ..Based on his skin biopsy findings, successful antiviral therapy was initiated. This case and a review of previously reported cases are discussed in this study...
  83. Foulongne V, Brieu N, Jeziorski E, Chatain A, Rodière M, Segondy M. KI and WU polyomaviruses in children, France. Emerg Infect Dis. 2008;14:523-5 pubmed publisher
  84. Becker J, Houben R, Ugurel S, Trefzer U, Pföhler C, Schrama D. MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol. 2009;129:248-50 pubmed publisher
  85. Palmieri A, Carinci F, Martinelli M, Spinelli G, Lo Muzio L, Rubini C, et al. Absence of Simian virus 40, BK, and JC polyomavirus DNA in squamous cell carcinoma limited to the oral cavity. Head Neck. 2010;32:375-80 pubmed publisher
    ..The Simian virus 40 (SV40), which is a polyomavirus known for its oncogenic potential, was found as a contaminant of oral vaccines and has been related to human ..
  86. White M, Safak M, Khalili K. Regulation of gene expression in primate polyomaviruses. J Virol. 2009;83:10846-56 pubmed publisher
  87. Groenewoud M, Fagrouch Z, van Gessel S, Niphuis H, Bulavaite A, Warren K, et al. Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans. J Gen Virol. 2010;91:653-8 pubmed publisher
    ..of sera from orang-utans demonstrated a high percentage of sera that cross-reacted with antigens of the polyomavirus (PyV) simian virus 40...
  88. Foulongne V, Kluger N, Dereure O, Mercier G, Moles J, Guillot B, et al. Merkel cell polyomavirus in cutaneous swabs. Emerg Infect Dis. 2010;16:685-7 pubmed publisher
    To assess the usefulness of using cutaneous swabs to detect Merkel cell polyomavirus (MCPyV) DNA, we analyzed swabs from persons with Merkel cell carcinoma (MCC), others with skin diseases, and healthy volunteers...
  89. Mangana J, Dziunycz P, Kerl K, Dummer R, Cozzio A. Prevalence of Merkel cell polyomavirus among Swiss Merkel cell carcinoma patients. Dermatology. 2010;221:184-8 pubmed publisher
    ..Recently, the clonal integration of a newly identified polyomavirus called Merkel cell polyomavirus (MCPyV) was reported in up to 80% of MCC tissue...
  90. Wellehan J, RIVERA R, Archer L, Benham C, Muller J, Colegrove K, et al. Characterization of California sea lion polyomavirus 1: expansion of the known host range of the Polyomaviridae to Carnivora. Infect Genet Evol. 2011;11:987-96 pubmed publisher
    The genome of a novel polyomavirus first identified in a proliferative tongue lesion of a California sea lion (Zalophus californianus) is reported...
  91. Van Ghelue M, Khan M, Ehlers B, Moens U. Genome analysis of the new human polyomaviruses. Rev Med Virol. 2012;22:354-77 pubmed publisher
    ..infecting birds or primates have been discovered, including seven human polyomaviruses: KI, WU, Merkel cell polyomavirus, HPyV6, HPyV7, trichodysplasia spinulosa-associated polyomavirus, and HPyV9...
  92. Tao Y, Shi M, Conrardy C, Kuzmin I, Recuenco S, Agwanda B, et al. Discovery of diverse polyomaviruses in bats and the evolutionary history of the Polyomaviridae. J Gen Virol. 2013;94:738-48 pubmed publisher
    ..In summary, this study revealed that bats are important reservoirs of PyVs and that these viruses have a complex evolutionary history...