Summary: A genus of DNA viruses in the family PAPILLOMAVIRIDAE. They preferentially infect the anogenital and ORAL MUCOSA in humans and primates, causing both malignant and benign neoplasms. Cutaneous lesions are also seen.

Top Publications

  1. Zhang D, Li T, Chen L, Zhang X, Zhao G, Liu Z. Epidemiological investigation of the relationship between common lower genital tract infections and high-risk human papillomavirus infections among women in Beijing, China. PLoS ONE. 2017;12:e0178033 pubmed publisher
    ..0001). The prevalence of LGTIs in Beijing is at a high level. It is clinically important to screen for the simultaneous presence of pathogens that cause co-infections with HR-HPV. ..
  2. Zekan J, Skerlev M, Milić L, Karelovic D. Human papillomavirus-related diseases of the female lower genital tract: oncogenic aspects and molecular interaction. Coll Antropol. 2014;38:779-86 pubmed
    ..Approximately 10% of individuals develop a persistent infection, and it is this cohort who is at risk of cancer progression, with the development of high-grade precursor lesions and eventually invasive carcinoma. ..
  3. Moore E, Hinni M. Critical review: transoral laser microsurgery and robotic-assisted surgery for oropharynx cancer including human papillomavirus-related cancer. Int J Radiat Oncol Biol Phys. 2013;85:1163-7 pubmed publisher
  4. Huq M, Nahar S, Alam A, Imam H, Rahman M. The prevalence of selected high-risk human papillomavirus infections among female sex workers in Dhaka, Bangladesh. Int J STD AIDS. 2012;23:151-2 pubmed publisher
  5. Grant D, Kravitz Wirtz N, Breen N, Tiro J, Tsui J. One in four California adolescent girls have had human papillomavirus vaccination. Policy Brief UCLA Cent Health Policy Res. 2009;:1-6 pubmed
  6. Godi A, Bissett S, Miller E, Beddows S. Impact of naturally occurring variation in the human papillomavirus (HPV) 33 capsid proteins on recognition by vaccine-induced cross-neutralizing antibodies. J Gen Virol. 2017;98:1755-1761 pubmed publisher
    ..These data improve our understanding of the potential impact of natural capsid variation on recognition by vaccine antibodies. ..
  7. Hang D, Jia M, Ma H, Zhou J, Feng X, Lyu Z, et al. Independent prognostic role of human papillomavirus genotype in cervical cancer. BMC Infect Dis. 2017;17:391 pubmed publisher
    ..001) for OS and 0.32 (95% CI: 0.17, 0.59; P < 0.001) for DFS. HPV genotype poses differential prognoses for cervical cancer patients. The presence of HPV16 and its related species alpha-9 indicates an improved survival. ..
  8. Field N, Lechner M. Exploring the implications of HPV infection for head and neck cancer. Sex Transm Infect. 2015;91:229-30 pubmed publisher
  9. Kirby T. FDA approves new upgraded Gardasil 9. Lancet Oncol. 2015;16:e56 pubmed publisher

More Information


  1. Campos N, Burger E, Sy S, Sharma M, Schiffman M, Rodriguez A, et al. An updated natural history model of cervical cancer: derivation of model parameters. Am J Epidemiol. 2014;180:545-55 pubmed publisher
  2. Petignat P, Vassilakos P. Is it time to introduce HPV self-sampling for primary cervical cancer screening?. J Natl Cancer Inst. 2012;104:166-7 pubmed publisher
  3. Parkin D. 11. Cancers attributable to infection in the UK in 2010. Br J Cancer. 2011;105 Suppl 2:S49-56 pubmed publisher
  4. . Recommendations on the use of quadrivalent human papillomavirus vaccine in males--Advisory Committee on Immunization Practices (ACIP), 2011. MMWR Morb Mortal Wkly Rep. 2011;60:1705-8 pubmed
    ..The evidence for HPV4 vaccination of males was evaluated using Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methods. ..
  5. Travassos A, Netto E, Xavier Souza E, Nóbrega I, Adami K, Timbó M, et al. Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women. PLoS ONE. 2017;12:e0185423 pubmed publisher
  6. Lopes R, Teixeira J, Marchioni D, Villa L, Giuliano A, Luiza Baggio M, et al. Dietary intake of selected nutrients and persistence of HPV infection in men. Int J Cancer. 2017;141:757-765 pubmed publisher
    ..003, test for trend). No association was observed between dietary intake and persistent oncogenic-type HPV infection; however, vitamin B12 intake was inversely associated with nononcogenic HPV persistence. ..
  7. Harper D, Demars L. HPV vaccines - A review of the first decade. Gynecol Oncol. 2017;146:196-204 pubmed publisher
    ..This simplifies and makes less expensive future comparative studies between existing and new generic vaccines. ..
  8. Reich O, Auner H, Puerstner P. Should human papillomavirus testing be performed in men participating in protocols of assisted reproduction?. Int J Androl. 2012;35:102 pubmed publisher
  9. Donalisio M, Cagno V, Vallino M, Moro G, Arslanoglu S, Tonetto P, et al. Inactivation of high-risk human papillomaviruses by Holder pasteurization: implications for donor human milk banking. J Perinat Med. 2014;42:1-8 pubmed publisher
    ..The results presented here indicate that the Holder pasteurization is an efficient procedure to inactivate high-risk and low-risk HPV thus preventing the potential risk of their transmission through human donor milk. ..
  10. Quon H, Forastiere A. Controversies in treatment deintensification of human papillomavirus-associated oropharyngeal carcinomas: should we, how should we, and for whom?. J Clin Oncol. 2013;31:520-2 pubmed publisher
  11. Mello C. Vaccination against human papillomavirus. Einstein (Sao Paulo). 2013;11:547-9 pubmed
    ..Currently two vaccines are available to prevent the human papillomavirus infection and its associated diseases. ..
  12. Xu B, Chotewutmontri S, Wolf S, Klos U, Schmitz M, Dürst M, et al. Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas. PLoS ONE. 2013;8:e66693 pubmed publisher
  13. Zhang L, Xie F, Wang X, Peng D, Bi C, Jiang L, et al. Previous cervical cytology and high-risk human papillomavirus testing in a cohort of patients with invasive cervical carcinoma in Shandong Province, China. PLoS ONE. 2017;12:e0180618 pubmed publisher
    ..As the addition of cytology to hrHPV testing can only marginally increase the efficiency of the hrHPV test, hrHPV testing should be used as the primary screening approach, especially in the low-resource settings of China. ..
  14. Herrero R. Human papillomavirus (HPV) vaccines: limited cross-protection against additional HPV types. J Infect Dis. 2009;199:919-22 pubmed publisher
  15. Wallace N, Khanal S, Robinson K, Wendel S, Messer J, Galloway D. High-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination Pathway. J Virol. 2017;91: pubmed publisher
    Persistent high-risk genus human Alphapapillomavirus (HPV) infections cause nearly every cervical carcinoma and a subset of tumors in the oropharyngeal tract...
  16. Nogueira Dias Genta M, Martins T, Mendoza Lopez R, Sadalla J, de Carvalho J, Baracat E, et al. Multiple HPV genotype infection impact on invasive cervical cancer presentation and survival. PLoS ONE. 2017;12:e0182854 pubmed publisher
    ..This is the largest study employing an automated HPV genotyping assay using FFPE of ICC. Multiple HPV genotype infection adversely influenced survival. ..
  17. Lucas Roxburgh R, Benschop J, Lockett B, van den Heever U, Williams R, Howe L. The prevalence of human papillomavirus in oropharyngeal cancer in a New Zealand population. PLoS ONE. 2017;12:e0186424 pubmed publisher
    ..Overseas studies have shown that human papillomavirus (HPV) plays a significant role in the development of these cancers. However, the role of HPV in OPC and the burden on the NZ health system is unclear...
  18. Rantshabeng P, Moyo S, Moraka N, Ndlovu A, MacLeod I, Gaseitsiwe S, et al. Prevalence of oncogenic human papillomavirus genotypes in patients diagnosed with anogenital malignancies in Botswana. BMC Infect Dis. 2017;17:731 pubmed publisher
    ..HPV types detected whereas in HIV-negative patients only HPV 16 was detected. Our study suggests that multivalent vaccines may be more suitable in this setting, especially for HIV-infected individuals. ..
  19. Vorsters A, Van Damme P, Clifford G. Urine testing for HPV: rationale for using first void. BMJ. 2014;349:g6252 pubmed publisher
  20. Nakajima H, Teraishi M, Tarutani M, Sano S. High prevalence of coinfection with mucosal high-risk type HPV (HR-HPV) and cutaneous HR-HPV in Bowen's disease in the fingers. J Dermatol Sci. 2010;60:50-2 pubmed publisher
  21. Lawson J, Glenn W, Whitaker N. Breast cancer as an infectious disease. Womens Health (Lond). 2010;6:5-8 pubmed publisher
  22. Strickler H. Does HIV/AIDS have a biological impact on the risk of human papillomavirus-related cancers?. J Natl Cancer Inst. 2009;101:1103-5 pubmed publisher
  23. Who -. Human papillomavirus vaccines: WHO position paper. Biologicals. 2009;37:338-44 pubmed publisher
  24. Mirabello L, Yeager M, Yu K, Clifford G, Xiao Y, Zhu B, et al. HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis. Cell. 2017;170:1164-1174.e6 pubmed publisher
    ..Strict conservation of the 98 amino acids of E7, which disrupts Rb function, is critical for HPV16 carcinogenesis, presenting a highly specific target for etiologic and therapeutic research. ..