myxoma virus

Summary

Summary: The type species of LEPORIPOXVIRUS causing infectious myxomatosis, a severe generalized disease, in rabbits. Tumors are not always present.

Top Publications

  1. Merchant J, Kerr P, Simms N, Robinson A. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. I. Natural occurrence of myxomatosis. Epidemiol Infect. 2003;130:113-21 pubmed
    ..carried out to establish the pattern of occurrence of myxomatosis in preparation for a deliberate release of myxoma virus. Myxomatosis was first detected in December and cases were found on most sites through to May...
  2. Blanié S, Mortier J, Delverdier M, Bertagnoli S, Camus Bouclainville C. M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit. Vet Res. 2009;40:11 pubmed publisher
    b>Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus)...
  3. Kerr P, Jackson R, Robinson A, Swan J, Silvers L, French N, et al. Infertility in female rabbits (Oryctolagus cuniculus) alloimmunized with the rabbit zona pellucida protein ZPB either as a purified recombinant protein or expressed by recombinant myxoma virus. Biol Reprod. 1999;61:606-13 pubmed
    ..To develop a delivery system, ZPB was delivered by infection with a recombinant myxoma virus. In contrast to the results with ZPB protein, infection of rabbits induced a similar serum antibody response to ..
  4. Everett H, Barry M, Lee S, Sun X, Graham K, Stone J, et al. M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes. J Exp Med. 2000;191:1487-98 pubmed
    M11L, a novel 166-amino acid membrane-associated protein expressed by the poxvirus, myxoma virus, was previously found to modulate apoptosis after infection of rabbit leukocytes...
  5. Thomas D, Doty R, Tosic V, Liu J, Kranz D, McFadden G, et al. Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors. Cancer Immunol Immunother. 2011;60:1461-72 pubmed publisher
    ..We evaluated a novel strategy to improve adoptive therapy by administering both T cells and oncolytic myxoma virus to mice with syngeneic B16.SIY melanoma brain tumors...
  6. Mossman K, Nation P, Macen J, Garbutt M, Lucas A, McFadden G. Myxoma virus M-T7, a secreted homolog of the interferon-gamma receptor, is a critical virulence factor for the development of myxomatosis in European rabbits. Virology. 1996;215:17-30 pubmed
    b>Myxoma virus is a leporipoxvirus of New World rabbits (Sylvilagus sp.) that induces a rapidly lethal infection known as myxomatosis in the European rabbit (Oryctolagus cuniculus)...
  7. Guerin J, Gelfi J, Camus C, Delverdier M, Whisstock J, Amardeihl M, et al. Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin involved in virulence. J Gen Virol. 2001;82:1407-17 pubmed
    b>Myxoma virus (MV), a member of the family Poxviridae, is the causative agent of myxomatosis, a fatal disease of the European rabbit...
  8. Stanford M, Barrett J, Nazarian S, Werden S, McFadden G. Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells. J Virol. 2007;81:1251-60 pubmed
    b>Myxoma virus is a rabbit-specific poxvirus pathogen that also exhibits a unique tropism for human tumor cells and is dramatically oncolytic for human cancer xenografts...
  9. Zhang L, Stanford M, Liu J, Barrett C, Jiang L, Barclay A, et al. Inhibition of macrophage activation by the myxoma virus M141 protein (vCD200). J Virol. 2009;83:9602-7 pubmed publisher
    The M141 protein of myxoma virus (MYXV) is a viral CD200 homolog (also called vOX-2) that inhibits macrophage activation in infected rabbits. Here, we show that murine myeloid RAW 264...

More Information

Publications118 found, 100 shown here

  1. Kerr P, Perkins H, Inglis B, Stagg R, McLaughlin E, Collins S, et al. Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis. Virology. 2004;324:117-28 pubmed
    ..IL-4 was expressed in the virulent standard laboratory strain (SLS) and the attenuated Uriarra (Ur) strain of myxoma virus with the aim of creating a Th2 cytokine environment and inhibiting the development of an antiviral cell-..
  2. Barrett J, Sypula J, Wang F, Alston L, Shao Z, Gao X, et al. M135R is a novel cell surface virulence factor of myxoma virus. J Virol. 2007;81:106-14 pubmed publisher
    b>Myxoma virus (MV) encodes a cell surface protein (M135R) that is predicted to mimic the host alpha/beta interferon receptor (IFN-alpha/beta-R) and thus prevent IFN-alpha/beta from triggering a host antiviral response...
  3. Morales M, Ramirez M, Cano M, Párraga M, Castilla J, Pérez Ordoyo L, et al. Genome comparison of a nonpathogenic myxoma virus field strain with its ancestor, the virulent Lausanne strain. J Virol. 2009;83:2397-403 pubmed publisher
    One of the best-studied examples of host-virus coevolution is the release of myxoma virus (MV) for biological control of European rabbits in Australia and Europe...
  4. Spiesschaert B, McFadden G, Hermans K, Nauwynck H, Van De Walle G. The current status and future directions of myxoma virus, a master in immune evasion. Vet Res. 2011;42:76 pubmed publisher
    b>Myxoma virus (MYXV) gained importance throughout the twentieth century because of the use of the highly virulent Standard Laboratory Strain (SLS) by the Australian government in the attempt to control the feral Australian population of ..
  5. Everett H, Barry M, Sun X, Lee S, Frantz C, Berthiaume L, et al. The myxoma poxvirus protein, M11L, prevents apoptosis by direct interaction with the mitochondrial permeability transition pore. J Exp Med. 2002;196:1127-39 pubmed
    ..b>Myxoma virus infection and the associated expression of early proteins, including M11L, protects cells from staurosporine- ..
  6. MacNeill A, Moldenhauer T, Doty R, Mann T. Myxoma virus induces apoptosis in cultured feline carcinoma cells. Res Vet Sci. 2012;93:1036-8 pubmed publisher
    ..The effectiveness of myxoma virus-induced oncolysis was evaluated in two feline cancer cell cultures...
  7. McCabe V, Tarpey I, Spibey N. Vaccination of cats with an attenuated recombinant myxoma virus expressing feline calicivirus capsid protein. Vaccine. 2002;20:2454-62 pubmed
    b>Myxoma virus, a member of the Poxviridae family (genus Leporipoxvirus) is the agent responsible for myxomatosis in the European rabbit...
  8. Richardson J, Viswanathan K, Lucas A. Serpins, the vasculature, and viral therapeutics. Front Biosci. 2006;11:1042-56 pubmed
    ..Viruses have encoded serpins to guard themselves from host immune attack. The myxoma virus which infects rabbits secretes a highly potent anti-inflammatory serpin, Serp-1, which targets thrombolytic and ..
  9. Jeklova E, Leva L, Matiasovic J, Kovarcik K, Kudlackova H, Nevorankova Z, et al. Characterisation of immunosuppression in rabbits after infection with myxoma virus. Vet Microbiol. 2008;129:117-30 pubmed publisher
    b>Myxoma virus (MXV) causes the systemic disease myxomatosis in the European rabbit...
  10. Hnatiuk S, Barry M, Zeng W, Liu L, Lucas A, Percy D, et al. Role of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and viral pathogenesis. Virology. 1999;263:290-306 pubmed
    The purpose of this study was to investigate the significance of the C-terminal RDEL motif of the myxoma virus M-T4 protein in terms of apoptosis regulation and role in viral virulence...
  11. Johnston J, Wang G, Barrett J, Nazarian S, Colwill K, Moran M, et al. Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1. J Virol. 2005;79:10750-63 pubmed
    The myxoma virus (MV) M-T5 gene encodes an ankyrin repeat protein that is important for virus replication in cells from several species...
  12. Chan W, Rahman M, McFadden G. Oncolytic myxoma virus: the path to clinic. Vaccine. 2013;31:4252-8 pubmed publisher
    ..One such preclinical candidate is myxoma virus (MYXV), a member of the Poxviridae family that, in its natural setting, exhibits a very restricted host range ..
  13. Kerr P, Ghedin E, DePasse J, Fitch A, Cattadori I, Hudson P, et al. Evolutionary history and attenuation of myxoma virus on two continents. PLoS Pathog. 2012;8:e1002950 pubmed publisher
    The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence...
  14. Dalton K, Ringleb F, Martín Alonso J, Parra F. Rapid identification of myxoma virus variants by long-range PCR and restriction fragment length polymorphism analysis. J Virol Methods. 2009;161:284-8 pubmed publisher
    A long-range PCR method directed at the Myxoma virus (MV) left hand and right hand terminal inverted repeats (TIRs) for rapid amplification of genomic DNA and MV isolate differentiation by restriction fragment length polymorphism (RFLP) ..
  15. Stanford M, Barrett J, Gilbert P, Bankert R, McFadden G. Myxoma virus expressing human interleukin-12 does not induce myxomatosis in European rabbits. J Virol. 2007;81:12704-8 pubmed
    b>Myxoma virus (MV) is a candidate for oncolytic virotherapy due to its ability to selectively infect and kill tumor cells, yet MV is a species-specific pathogen that causes disease only in European rabbits...
  16. Marlier D, Mainil J, Boucraut Baralon C, Linden A, Vindevogel H. The efficacy of two vaccination schemes against experimental infection with a virulent amyxomatous or a virulent nodular myxoma virus strain. J Comp Pathol. 2000;122:115-22 pubmed
    ..commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33...
  17. France M, Thomas D, Liu J, McFadden G, MacNeill A, Roy E. Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells. J Gen Virol. 2011;92:195-9 pubmed publisher
    Oncolytic viruses that selectively infect and lyse cancer cells have potential as therapeutic agents. Myxoma virus, a poxvirus that is known to be pathogenic only in rabbits, has not been reported to infect normal tissues in humans or ..
  18. Messud Petit F, Gelfi J, Delverdier M, Amardeilh M, Py R, Sutter G, et al. Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus. J Virol. 1998;72:7830-9 pubmed
    Recently, myxoma virus was shown to encode an additional member of the serpin superfamily...
  19. Castedo M, Perfettini J, Kroemer G. Mitochondrial apoptosis and the peripheral benzodiazepine receptor: a novel target for viral and pharmacological manipulation. J Exp Med. 2002;196:1121-5 pubmed
  20. Merchant J, Kerr P, Simms N, Hood G, Pech R, Robinson A. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. III. Release, persistence and rate of spread of an identifiable strain of myxoma virus. Epidemiol Infect. 2003;130:135-47 pubmed
    An identifiable strain of myxoma virus was introduced into four local populations of wild rabbits Oryctolagus cuniculus on the southern tablelands of New South Wales (NSW) and its spread in the presence of other field strains was ..
  21. Johnston J, Barrett J, Nazarian S, Goodwin M, Ricciuto D, Ricuttio D, et al. A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection. Immunity. 2005;23:587-98 pubmed
    ..Thus, modulation of inflammasome function constitutes an important immunomodulatory strategy employed by poxviruses to circumvent host antiviral responses. ..
  22. Wang F, Gao X, Barrett J, Shao Q, Bartee E, Mohamed M, et al. RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages. PLoS Pathog. 2008;4:e1000099 pubmed publisher
    ..b>Myxoma virus (MV) is a cytoplasmic DNA poxvirus that in nature infects only rabbits...
  23. Adams M, van Leeuwen B, Kerr P. Construction and evaluation of live attenuated myxoma virus vaccines with targeted virulence gene deletions. Vaccine. 2008;26:5843-54 pubmed publisher
    ..were constructed as potential vaccines against myxomatosis using the naturally attenuated Uriarra strain of myxoma virus. The viruses had the M007 (encodes a secreted gamma-interferon receptor homologue), M010 (encodes an epidermal ..
  24. Wennier S, Liu J, Li S, Rahman M, Mona M, McFadden G. Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer. Mol Ther. 2012;20:759-68 pubmed publisher
    b>Myxoma virus (MYXV) is a novel oncolytic virus that has been shown to replicate in pancreatic cancer cells, but its efficacy in animal models of pancreatic cancer has not been determined...
  25. Ramelot T, Cort J, Yee A, Liu F, Goshe M, Edwards A, et al. Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha. J Mol Biol. 2002;322:943-54 pubmed
    ..M156R, the product of the myxoma virus M156R open reading frame, has sequence similarity to eIF2alpha as well as to a family of viral proteins that ..
  26. Labudovic A, Perkins H, van Leeuwen B, Kerr P. Sequence mapping of the Californian MSW strain of Myxoma virus. Arch Virol. 2004;149:553-70 pubmed
    Partial sequence mapping of the MSW Californian strain of Myxoma virus was performed by cloning EcoRI and SalI restriction fragments of viral DNA and sequencing the ends of these...
  27. Johnston J, Nazarian S, Natale R, McFadden G. Myxoma virus infection of primary human fibroblasts varies with cellular age and is regulated by host interferon responses. Virology. 2005;332:235-48 pubmed
    ..studies have indicated a critical role for interferon (IFN)-mediated antiviral responses in the host range of myxoma virus (MV), a pathogenic poxvirus of rabbits...
  28. Lun X, Zhou H, Alain T, Sun B, Wang L, Barrett J, et al. Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin. Cancer Res. 2007;67:8818-27 pubmed
    We have shown previously the oncolytic potential of myxoma virus in a murine xenograft model of human glioma...
  29. Kerr P, Best S. Myxoma virus in rabbits. Rev Sci Tech. 1998;17:256-68 pubmed
    b>Myxoma virus in European rabbits (Oryctolagus cuniculus) is one of the best documented examples of host-virus co-evolution. In the natural hosts (Sylvilagus brasiliensis or S...
  30. Camus Bouclainville C, Fiette L, Bouchiha S, Pignolet B, Counor D, Filipe C, et al. A virulence factor of myxoma virus colocalizes with NF-kappaB in the nucleus and interferes with inflammation. J Virol. 2004;78:2510-6 pubmed
    ..b>Myxoma virus, a member of the Poxviridae family responsible for rabbit myxomatosis, codes for several factors that help its ..
  31. Barrett J, Alston L, Wang F, Stanford M, Gilbert P, Gao X, et al. Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells. J Neurovirol. 2007;13:549-60 pubmed
    The authors have recently demonstrated that wild-type myxoma virus (MV) tagged with gfp (vMyxgfp) can generate a tumor-specific infection that productively infects and clears human tumor-derived xenografts when injected intratumorally ..
  32. Kerr P, Hone J, Perrin L, French N, Williams C. Molecular and serological analysis of the epidemiology of myxoma virus in rabbits. Vet Microbiol. 2010;143:167-78 pubmed publisher
    The epidemiology of myxoma virus was studied by serology and molecular analysis of restriction fragment length polymorphisms (RFLPs) in genomic DNA...
  33. Barry M, Hnatiuk S, Mossman K, Lee S, Boshkov L, McFadden G. The myxoma virus M-T4 gene encodes a novel RDEL-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes. Virology. 1997;239:360-77 pubmed publisher
    To investigate the contribution of the myxoma virus M-T4 gene to viral virulence, both copies of the M-T4 gene were inactivated by disruption and insertion of the Escherichia coli guanosine phosphoribosyltransferase gene...
  34. Barrett J, Werden S, Wang F, McKillop W, Jimenez J, Villeneuve D, et al. Myxoma virus M130R is a novel virulence factor required for lethal myxomatosis in rabbits. Virus Res. 2009;144:258-65 pubmed publisher
    b>Myxoma virus (MV) is a highly lethal, rabbit-specific poxvirus that induces a disease called myxomatosis in European rabbits...
  35. Muller A, Silva E, Abrantes J, Esteves P, Ferreira P, Carvalheira J, et al. Partial sequencing of recent Portuguese myxoma virus field isolates exhibits a high degree of genetic stability. Vet Microbiol. 2010;140:161-6 pubmed publisher
    To study genetic changes underlying myxoma virus evolution in its new host, the European rabbit (Oryctolagus cuniculus), we sequenced selected genomic regions of nine recent virulent field strains and a live attenuated vaccine strain (&..
  36. Upton C, Macen J, Maranchuk R, DeLange A, McFadden G. Tumorigenic poxviruses: fine analysis of the recombination junctions in malignant rabbit fibroma virus, a recombinant between Shope fibroma virus and myxoma virus. Virology. 1988;166:229-39 pubmed
    ..from a recombination event between Shope fibroma virus (SFV), which induces benign fibromas in rabbits, and myxoma virus, the agent of myxomatosis...
  37. Lalani A, Masters J, Graham K, Liu L, Lucas A, McFadden G. Role of the myxoma virus soluble CC-chemokine inhibitor glycoprotein, M-T1, during myxoma virus pathogenesis. Virology. 1999;256:233-45 pubmed
    b>Myxoma virus is a poxvirus that causes a virulent systemic disease called myxomatosis in European rabbits. Like many poxviruses, myxoma virus encodes a variety of secreted proteins that subvert the antiviral activities of host cytokines...
  38. Zachertowska A, Brewer D, Evans D. Characterization of the major capsid proteins of myxoma virus particles using MALDI-TOF mass spectrometry. J Virol Methods. 2006;132:1-12 pubmed
    ..b>Myxoma virus particles were purified using sucrose and Nicodenz gradient centrifugation and subfractionated into membrane ..
  39. Werden S, Barrett J, Wang G, Stanford M, McFadden G. M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. J Virol. 2007;81:2340-8 pubmed publisher
    The myxoma virus (MV) ankyrin repeat, host range factor M-T5 has the ability to bind and activate cellular Akt, leading to permissive MV replication in a variety of diverse human cancer cell lines (G. Wang, J. W. Barrett, M. Stanford, S...
  40. Wang F, Barrett J, Shao Q, Gao X, Dekaban G, McFadden G. Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2. Virology. 2009;387:136-46 pubmed publisher
    ..b>Myxoma virus (MV) is a highly species-restricted member of the poxvirus family that infects only rabbits under the natural ..
  41. Lun X, Alain T, Zemp F, Zhou H, Rahman M, Hamilton M, et al. Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with rapamycin. Cancer Res. 2010;70:598-608 pubmed publisher
    Oncolytic myxoma virus (MYXV) is being developed as a novel virotherapeutic against human brain cancer and has promising activity against human brain tumor models in immunocompromised hosts...
  42. García Bocanegra I, Astorga R, Napp S, Casal J, Huerta B, Borge C, et al. Myxomatosis in wild rabbit: design of control programs in Mediterranean ecosystems. Prev Vet Med. 2010;93:42-50 pubmed publisher
    ..wild rabbit (Oryctolagus cuniculus) populations from southern Spain to identify risk factors associated to myxoma virus infection...
  43. Madlambayan G, Bartee E, Kim M, Rahman M, Meacham A, Scott E, et al. Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro. Leuk Res. 2012;36:619-24 pubmed publisher
    Some oncolytic viruses, such as myxoma virus (MYXV), can selectively target malignant hematopoietic cells, while sparing normal hematopoietic cells...
  44. Boshkov L, Macen J, McFadden G. Virus-induced loss of class I MHC antigens from the surface of cells infected with myxoma virus and malignant rabbit fibroma virus. J Immunol. 1992;148:881-7 pubmed
    ..b>Myxoma virus (MYX) and malignant rabbit fibroma virus (MRV) are related leporipoxviruses that induce rapidly lethal ..
  45. Upton C, Macen J, Wishart D, McFadden G. Myxoma virus and malignant rabbit fibroma virus encode a serpin-like protein important for virus virulence. Virology. 1990;179:618-31 pubmed
    The leporipoxviruses Shope fibroma virus (SFV), the myxoma virus (MYX), and the SFV/MYX recombinant malignant rabbit fibroma virus (MRV) are closely related yet induce profoundly different diseases in the European rabbit...
  46. Rahman M, Madlambayan G, Cogle C, McFadden G. Oncolytic viral purging of leukemic hematopoietic stem and progenitor cells with Myxoma virus. Cytokine Growth Factor Rev. 2010;21:169-75 pubmed publisher
    ..Here we summarize an ex vivo "purging" strategy with oncolytic Myxoma virus (MYXV) to remove cancer-initiating cells from patient autografts prior to transplantation...
  47. Cao H, Dai P, Wang W, Li H, Yuan J, Wang F, et al. Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain. PLoS ONE. 2012;7:e36823 pubmed publisher
    ..In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus. Vaccinia, an orthopoxvirus, was used for immunization against smallpox, a contagious human disease with high ..
  48. Kim M, Williamson C, Prudhomme J, Bebb D, Riabowol K, Lee P, et al. The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. Oncogene. 2010;29:3990-6 pubmed publisher
    ..Importantly, many oncolytic virus candidates, such as reovirus and myxoma virus, preferentially infect cancer cells bearing abnormal cellular signaling pathways...
  49. Fenner F. Deliberate introduction of the European rabbit, Oryctolagus cuniculus, into Australia. Rev Sci Tech. 2010;29:103-11 pubmed
    ..After careful testing in Australian wildlife and in humans, control by myxoma virus was introduced at various sites between 1937 and 1950, spreading all over the Murray-Darling Basin in 1950...
  50. Liu J, Wennier S, McFadden G. The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics. Microbes Infect. 2010;12:1144-52 pubmed publisher
    b>Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species...
  51. Barrett J, Shun Chang C, Wang G, Werden S, Shao Z, Barrett C, et al. Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells. Virology. 2007;361:123-32 pubmed
    The myxoma virus M063R gene product exhibits some sequence similarity to the poxvirus host range gene, C7L, of vaccinia virus...
  52. Ferreira C, Ramírez E, Castro F, Ferreras P, Alves P, Redpath S, et al. Field experimental vaccination campaigns against myxomatosis and their effectiveness in the wild. Vaccine. 2009;27:6998-7002 pubmed publisher
    ..Results suggest that only a costly and systematic vaccination performed before the annual myxomatosis outbreak, would improve the survival of juvenile rabbits, a premise not always accomplished that compromises its efficacy in the field...
  53. Rahman M, Mohamed M, Kim M, Smallwood S, McFadden G. Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013. PLoS Pathog. 2009;5:e1000635 pubmed publisher
    ..b>Myxoma virus (MYXV), a pathogenic poxvirus of rabbits, encodes a member of the cellular pyrin domain (PYD) superfamily, ..
  54. Kerr P, Rogers M, Fitch A, DePasse J, Cattadori I, Twaddle A, et al. Genome scale evolution of myxoma virus reveals host-pathogen adaptation and rapid geographic spread. J Virol. 2013;87:12900-15 pubmed publisher
    The evolutionary interplay between myxoma virus (MYXV) and the European rabbit (Oryctolagus cuniculus) following release of the virus in Australia in 1950 as a biological control is a classic example of host-pathogen coevolution...
  55. Adams M, van Leeuwen B, McFadden G, Kerr P. Construction and testing of a novel host-range defective myxoma virus vaccine with the M063 gene inactivated that is non-permissive for replication in rabbit cells. Vet Res. 2008;39:60 pubmed publisher
    Deletion of the M063 gene from myxoma virus produces a virus that is unable to replicate in rabbit cells in vitro or in live rabbits but can be propagated in non-rabbit cell lines...
  56. Alda F, Gaitero T, Suarez M, Doadrio I. Molecular characterisation and recent evolution of myxoma virus in Spain. Arch Virol. 2009;154:1659-70 pubmed publisher
    b>Myxoma virus and the European rabbit are one of the best-studied examples of coevolution of pathogen virulence and host resistance...
  57. Macen J, Upton C, Nation N, McFadden G. SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation. Virology. 1993;195:348-63 pubmed
    b>Myxoma virus is a leporipoxvirus that causes a rapidly lethal, generalized infection known as myxomatosis in the European rabbit (Oryctolagus cuniculus)...
  58. Su J, Wang G, Barrett J, Irvine T, Gao X, McFadden G. Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria. J Virol. 2006;80:1140-51 pubmed publisher
    ..M11L, a myxoma virus-encoded antiapoptotic protein, has been previously shown to localize to mitochondria and block apoptosis of ..
  59. Bartee E, McFadden G. Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta. Cytokine. 2009;47:199-205 pubmed publisher
    ..We hypothesize that the ability to induce the TNF/IFNbeta synergistic state is a unique feature of primary cells and is incompatible with cellular immortalization and/or transformation...
  60. Blanié S, Gelfi J, Bertagnoli S, Camus Bouclainville C. MNF, an ankyrin repeat protein of myxoma virus, is part of a native cellular SCF complex during viral infection. Virol J. 2010;7:56 pubmed publisher
    b>Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus)...
  61. Wang G, Barrett J, Nazarian S, Everett H, Gao X, Bleackley C, et al. Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. J Virol. 2004;78:7097-111 pubmed
    M11L, a 166-amino-acid antiapoptotic protein of myxoma virus, was previously shown to bind to the peripheral benzodiazepine receptor by hydrophobic interactions at the outer mitochondrial membrane...
  62. Adams M, van Leeuwen B, Kerr P. Limitations of plasmid vaccines to complex viruses: selected myxoma virus antigens as DNA vaccines were not protective. Vaccine. 2004;23:198-204 pubmed
    b>Myxoma virus, a poxvirus of the genus Leporipoxvirus, is the causative agent of the disease myxomatosis which is highly lethal in European rabbits (Oryctolagus cuniculus)...
  63. Cameron C, Barrett J, Liu L, Lucas A, McFadden G. Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo. J Virol. 2005;79:6052-67 pubmed
    M141R is a myxoma virus gene that encodes a cell surface protein with significant amino acid similarity to the family of cellular CD200 (OX-2) proteins implicated in the regulation of myeloid lineage cell activation...
  64. Stanford M, Werden S, McFadden G. Myxoma virus in the European rabbit: interactions between the virus and its susceptible host. Vet Res. 2007;38:299-318 pubmed
    b>Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O...
  65. Stanford M, Shaban M, Barrett J, Werden S, Gilbert P, Bondy Denomy J, et al. Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo. Mol Ther. 2008;16:52-9 pubmed
    b>Myxoma virus (MV) is a rabbit-specific poxvirus, whose unexpected tropism to human cancer cells has led to studies exploring its potential use in oncolytic therapy...
  66. Woo Y, Kelly K, Stanford M, Galanis C, Chun Y, Fong Y, et al. Myxoma virus is oncolytic for human pancreatic adenocarcinoma cells. Ann Surg Oncol. 2008;15:2329-35 pubmed publisher
    ..Our study investigates the ability of a novel oncolytic agent, myxoma virus, to infect, productively replicate in, and kill human pancreatic cancer cells in vitro.
  67. Liu J, Wennier S, Zhang L, McFadden G. M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells. J Virol. 2011;85:3270-82 pubmed publisher
    b>Myxoma virus (MYXV) M062R is a functional homolog of the C7L family of host range genes from orthopoxviruses. We constructed a targeted M062R-knockout-MYXV (vMyxM062-KO) and characterized its properties in vitro and in vivo...
  68. Upton C, Macen J, Schreiber M, McFadden G. Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence. Virology. 1991;184:370-82 pubmed
    ..We have sequenced the terminal regions of two other Leporipoxviruses (myxoma virus and malignant rabbit fibroma virus) that are extremely invasive and capable of inducing extensive ..
  69. Mossman K, Lee S, Barry M, Boshkov L, McFadden G. Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits. J Virol. 1996;70:4394-410 pubmed
    b>Myxoma virus is a pathogenic poxvirus that induces a lethal myxomatosis disease profile in European rabbits, which is characterized by fulminating lesions at the primary site of inoculation, rapid dissemination to secondary internal ..
  70. Gelfi J, Chantal J, Phong T, Py R, Boucraut Baralon C. Development of an ELISA for detection of myxoma virus-specific rabbit antibodies: test evaluation for diagnostic applications on vaccinated and wild rabbit sera. J Vet Diagn Invest. 1999;11:240-5 pubmed
    ..compared with 2 reference diagnostic tests (indirect immunofluorescence [IF] and complement fixation) to detect myxoma virus-specific antibodies in sera from 50 rabbits experimentally vaccinated with an attenuated strain of myxoma virus ..
  71. Barrett J, Cao J, Hota Mitchell S, McFadden G. Immunomodulatory proteins of myxoma virus. Semin Immunol. 2001;13:73-84 pubmed
    ..review we draw attention to some of the new open reading frames (ORFs) discovered during the sequencing of the myxoma virus DNA genome [Cameron C, Hota-Mitchell S, Chen L, Barrett J, Cao J-X, Macaulay C, Willer D, Evans D, McFadden G (..
  72. Torres J, Sanchez C, Ramirez M, Morales M, Barcena J, Ferrer J, et al. First field trial of a transmissible recombinant vaccine against myxomatosis and rabbit hemorrhagic disease. Vaccine. 2001;19:4536-43 pubmed
    ..a transmissible vaccine against myxomatosis and rabbit hemorrhagic disease (RHD) based on a recombinant myxoma virus (MV) expressing the RHDV capsid protein [J. Virol. 74 (2000) 1114]...
  73. ZUNIGA M. Lessons in détente or know thy host: the immunomodulatory gene products of myxoma virus. J Biosci. 2003;28:273-85 pubmed
    The poxvirus, myxoma virus, encodes within its genome at least eleven different proteins that compromise, skew, or disable the innate and adaptive responses of its hosts...
  74. Cavadini P, Botti G, Barbieri I, Lavazza A, Capucci L. Molecular characterization of SG33 and Borghi vaccines used against myxomatosis. Vaccine. 2010;28:5414-20 pubmed publisher
    b>Myxoma virus is a poxvirus responsible for myxomatosis in European Rabbits (Oryctolagus cuniculus)...
  75. Dai P, Cao H, Merghoub T, Avogadri F, Wang W, Parikh T, et al. Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway. J Virol. 2011;85:10814-25 pubmed publisher
    Poxviruses are large DNA viruses that replicate in the cytoplasm of infected cells. Myxoma virus is a rabbit poxvirus that belongs to the Leporipoxvirus genus...
  76. Teferi W, Dodd K, Maranchuk R, Favis N, Evans D. A whole-genome RNA interference screen for human cell factors affecting myxoma virus replication. J Virol. 2013;87:4623-41 pubmed publisher
    b>Myxoma virus (MYXV) provides an important model for investigating host-pathogen interactions. Recent studies have also highlighted how mutations in transformed human cells can expand the host range of this rabbit virus...
  77. Robinson A, Muller W, Braid A, Kerr P. The effect of buprenorphine on the course of disease in laboratory rabbits infected with myxoma virus. Lab Anim. 1999;33:252-7 pubmed
    The only method of assessing the virulence of myxoma virus is to record survival times of rabbits inoculated with the virus. This raises ethical concerns about using animals in experiments where death is the end point...
  78. Guerin J, Gelfi J, Boullier S, Delverdier M, Bellanger F, Bertagnoli S, et al. Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins. J Virol. 2002;76:2912-23 pubmed
    ..b>Myxoma virus, a member of the Poxviridae family responsible for rabbit myxomatosis, can down-modulate the expression of MHC-..
  79. Wang F, Ma Y, Barrett J, Gao X, Loh J, Barton E, et al. Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier. Nat Immunol. 2004;5:1266-74 pubmed
    b>Myxoma virus, a member of the poxvirus family, causes lethal infection only in rabbits, but the mechanism underlying the strict myxoma virus species barrier is not known...
  80. Cameron C, Barrett J, Mann M, Lucas A, McFadden G. Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo. Virology. 2005;337:55-67 pubmed
    The M128L myxoma virus gene expresses a five-membrane spanning cell surface protein with significant amino acid homology to the cellular CD47 proteins...
  81. Wang G, Barrett J, Stanford M, Werden S, Johnston J, Gao X, et al. Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor. Proc Natl Acad Sci U S A. 2006;103:4640-5 pubmed
    We demonstrate that the susceptibility of human cancer cells to be infected and killed by an oncolytic poxvirus, myxoma virus (MV), is related to the basal level of endogenous phosphorylated Akt...
  82. Douglas A, Corbett K, Berger J, McFadden G, Handel T. Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 2007;16:695-703 pubmed
    ..One such antiapoptotic protein, myxoma virus M11L, has been shown to inhibit mitochondrial-dependent apoptosis by binding to and blocking the two ..
  83. Rahman M, Liu J, Chan W, Rothenburg S, McFadden G. Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. PLoS Pathog. 2013;9:e1003465 pubmed publisher
    b>Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways...
  84. Nash P, Barrett J, Cao J, Hota Mitchell S, Lalani A, Everett H, et al. Immunomodulation by viruses: the myxoma virus story. Immunol Rev. 1999;168:103-20 pubmed
    b>Myxoma virus is a poxvirus pathogen of rabbits that has evolved to replicate successfully in the presence of an active immune response by an infected host...
  85. Marlier D, Herbots J, Detilleux J, Lemaire M, Thiry E, Vindevogel H. Cross-sectional study of the association between pathological conditions and myxoma-virus seroprevalence in intensive rabbit farms in Europe. Prev Vet Med. 2001;48:55-64 pubmed
    ..whereas that of amyxomatous forms must be based on virus isolation or detection of specific antibodies to myxoma virus (MV)...
  86. Kerr P, McFadden G. Immune responses to myxoma virus. Viral Immunol. 2002;15:229-46 pubmed
    b>Myxoma virus causes the systemic disease myxomatosis in the European rabbit (Oryctolagus cuniculus)...
  87. Johnston J, Barrett J, Chang W, Chung C, Zeng W, Masters J, et al. Role of the serine-threonine kinase PAK-1 in myxoma virus replication. J Virol. 2003;77:5877-88 pubmed
    ..Using subsets of 3T3 murine fibroblasts previously shown to differ in their ability to support myxoma virus (MV) replication, we investigated the role of host serine-threonine kinases (STKs) as potential mediators of ..
  88. McCabe V, Spibey N. Potential for broad-spectrum protection against feline calicivirus using an attenuated myxoma virus expressing a chimeric FCV capsid protein. Vaccine. 2005;23:5380-8 pubmed
    ..Such a chimeric vaccine may provide effective protection against a wide range of FCV strains...
  89. Silvers L, Inglis B, Labudovic A, Janssens P, Van Leeuwen B, Kerr P. Virulence and pathogenesis of the MSW and MSD strains of Californian myxoma virus in European rabbits with genetic resistance to myxomatosis compared to rabbits with no genetic resistance. Virology. 2006;348:72-83 pubmed
    The pathogenesis of two Californian strains of myxoma virus (MSW and MSD) was examined in European rabbits (Oryctolagus cuniculus) that were either susceptible to myxomatosis (laboratory rabbits) or had undergone natural selection for ..
  90. Wang F, Barrett J, Ma Y, Dekaban G, McFadden G. Induction of alpha/beta interferon by myxoma virus is selectively abrogated when primary mouse embryo fibroblasts become immortalized. J Virol. 2009;83:5928-32 pubmed publisher
    ..Here, we show that although primary MEFs are nonpermissive to myxoma virus replication, the corresponding immortalized MEFs support a highly productive myxoma virus infection...
  91. Guitton J, Devillard S, Guénézan M, Fouchet D, Pontier D, Marchandeau S. Vaccination of free-living juvenile wild rabbits (Oryctolagus cuniculus) against myxomatosis improved their survival. Prev Vet Med. 2008;84:1-10 pubmed
    ..8-fold greater odds of surviving than the unvaccinated rabbits. The average summer survival risk for vaccinated juveniles was 0.63 (+/-0.08 S.E.) whereas it was 0.48 (+/-0.08 S.E.) for unvaccinated juvenile rabbits...
  92. Dalton K, Ringleb F, Martín Alonso J, Parra F. Rapid purification of myxoma virus DNA. J Virol Methods. 2009;162:284-7 pubmed publisher
    A rapid and efficient procedure for the purification of myxoma virus DNA from infected cell cultures is described...