human herpesvirus 8

Summary

Summary: A species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and "classical" Kaposi sarcoma.

Top Publications

  1. Boulanger E, Marchio A, Hong S, Pineau P. Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma. Haematologica. 2009;94:1170-4 pubmed publisher
    b>Human herpesvirus 8 (HHV-8)-associated primary effusion lymphoma is a rare non-Hodgkin's lymphoma often associated with Epstein-Barr virus (EBV) infection...
  2. Minhas V, Crabtree K, Chao A, M soka T, Kankasa C, Bulterys M, et al. Early childhood infection by human herpesvirus 8 in Zambia and the role of human immunodeficiency virus type 1 coinfection in a highly endemic area. Am J Epidemiol. 2008;168:311-20 pubmed publisher
    ..sarcoma occurs at high incidence among Zambian adults and children, but there is a paucity of data on human herpesvirus 8 (HHV-8) incidence and routes of infection, especially in children...
  3. Cassar O, Blondot M, Mohanna S, Jouvion G, Bravo F, Maco V, et al. Human herpesvirus 8 genotype E in patients with Kaposi sarcoma, Peru. Emerg Infect Dis. 2010;16:1459-62 pubmed publisher
    To determine human herpesvirus 8 (HHV-8) K1 genotypes in patients with Kaposi sarcoma (KS) from Peru, we characterized HHV-8 in 25 KS biopsy samples...
  4. Burbelo P, Leahy H, Groot S, Bishop L, Miley W, Iadarola M, et al. Four-antigen mixture containing v-cyclin for serological screening of human herpesvirus 8 infection. Clin Vaccine Immunol. 2009;16:621-7 pubmed publisher
    Improved diagnostic reagents and testing are currently needed for the serological detection of human herpesvirus 8 (HHV-8) infections...
  5. Nsubuga M, Biggar R, Combs S, Marshall V, Mbisa G, Kambugu F, et al. Human herpesvirus 8 load and progression of AIDS-related Kaposi sarcoma lesions. Cancer Lett. 2008;263:182-8 pubmed publisher
    b>Human herpesvirus 8 (HHV8) is necessary for Kaposi sarcoma (KS) to develop, but whether peripheral blood viral load is a marker of KS burden (total number of KS lesions), KS progression (the rate of eruption of new KS lesions), or both ..
  6. Boyne J, Colgan K, Whitehouse A. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog. 2008;4:e1000194 pubmed publisher
    ..Together, these data provide the first direct evidence that the complete hTREX complex is essential for the export of KSHV intronless mRNAs and infectious virus production. ..
  7. Cassar O, Afonso P, Bassot S, Plancoulaine S, Duprez R, Capuano C, et al. Novel human herpesvirus 8 subtype D strains in Vanuatu, Melanesia. Emerg Infect Dis. 2007;13:1745-8 pubmed publisher
    We show human herpesvirus 8 with diverse molecular subtype D variants to be highly endemic among the Ni-Vanuatu population...
  8. Ziegelbauer J, Sullivan C, Ganem D. Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs. Nat Genet. 2009;41:130-4 pubmed publisher
    ..Our results support that this type of expression profiling provides a potentially general approach to the identification of miRNA targets. ..
  9. Chang P, Fitzgerald L, Van Geelen A, Izumiya Y, Ellison T, Wang D, et al. Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. Cancer Res. 2009;69:5681-9 pubmed publisher
    ..In summary, the cellular transcriptional repressor KAP-1 plays a role in regulating KSHV latency, and viral protein kinase modulates the chromatin remodeling function of this repressor. ..

More Information

Publications81

  1. McClure L, Sullivan C. Kaposi's sarcoma herpes virus taps into a host microRNA regulatory network. Cell Host Microbe. 2008;3:1-3 pubmed publisher
    ..Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis. ..
  2. Sivakumar R, Sharma Walia N, Raghu H, Veettil M, Sadagopan S, Bottero V, et al. Kaposi's sarcoma-associated herpesvirus induces sustained levels of vascular endothelial growth factors A and C early during in vitro infection of human microvascular dermal endothelial cells: biological implications. J Virol. 2008;82:1759-76 pubmed
    ..Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) is etiologically linked to KS, and in vitro KSHV infection of primary human dermal microvascular ..
  3. Nascimento M, de Souza V, Sumita L, Freire W, Weiss H, Sabino E, et al. Prevalence of, and risk factors for Kaposi's sarcoma-associated herpesvirus infection among blood donors in Brazil: a multi-center serosurvey. J Med Virol. 2008;80:1202-10 pubmed publisher
    ..KSHV seroprevalence is high among Brazilian blood donors, particularly from the Amazon region. This study supports the co-existence of sexual and non-sexual routes of KSHV transmission in this population...
  4. Li Q, Zhou F, Ye F, Gao S. Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program. Virology. 2008;379:234-44 pubmed publisher
    ..Together, these results have demonstrated that, in the context of viral genome, LANA contributes to KSHV latency by regulating the expression of RTA and its downstream genes. ..
  5. Boyne J, Whitehouse A. Nucleolar disruption impairs Kaposi's sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs. FEBS Lett. 2009;583:3549-56 pubmed publisher
    ..We show that rapid disorganisation of the nucleolus was accompanied by a reduction in intronless virus mRNA export, suggesting that an intact nucleolus is essential for efficient KSHV ORF57-mediated intronless mRNA export. ..
  6. Murphy E, Vanicek J, Robins H, Shenk T, Levine A. Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency. Proc Natl Acad Sci U S A. 2008;105:5453-8 pubmed publisher
    ..We propose that herpesviruses use microRNA-mediated suppression of immediate-early genes as part of their strategy to enter and maintain latency. ..
  7. Krown S, Lee J, Dittmer D. More on HIV-associated Kaposi's sarcoma. N Engl J Med. 2008;358:535-6; author reply 536 pubmed publisher
  8. Di Bartolo D, Cannon M, Liu Y, Renne R, Chadburn A, Boshoff C, et al. KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor. Blood. 2008;111:4731-40 pubmed publisher
  9. Gould F, Harrison S, Hewitt E, Whitehouse A. Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway. J Virol. 2009;83:6727-38 pubmed publisher
  10. McDonald A, RAGIN C, Jenkins F, Weissfeld J, Wilson J, Wheeler V, et al. Human herpesvirus 8 seroprevalence among Tobago women and the role of sexual lifestyle behavior. J Med Virol. 2009;81:264-70 pubmed publisher
    b>Human herpesvirus 8 (HHV-8) infection is present in 22.9% of Tobago men. However, seroprevalence and modes of transmission of HHV-8 among Tobago women are not known...
  11. Hensler H, Rappocciolo G, Rinaldo C, Jenkins F. Cytokine production by human herpesvirus 8-infected dendritic cells. J Gen Virol. 2009;90:79-83 pubmed publisher
    We have shown previously that human herpesvirus 8 (HHV-8)-infected dendritic cells (DCs) undergo incomplete maturation and have a defective antigen-presenting function...
  12. Minhas V, Crosby L, Crabtree K, Phiri S, M soka T, Kankasa C, et al. Development of an immunofluorescence assay using recombinant proteins expressed in insect cells to screen and confirm presence of human herpesvirus 8-specific antibodies. Clin Vaccine Immunol. 2008;15:1259-64 pubmed publisher
    b>Human herpesvirus 8 (HHV-8), or Kaposi's sarcoma (KS)-associated herpesvirus, has been linked to all forms of KS...
  13. Wilson S, Tsao E, Webb B, Ye H, Dalton Griffin L, Tsantoulas C, et al. X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. J Virol. 2007;81:13578-86 pubmed
    ..This links B-cell terminal differentiation to KSHV lytic reactivation...
  14. Majerciak V, Kruhlak M, Dagur P, McCoy J, Zheng Z. Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression. J Biol Chem. 2010;285:11297-307 pubmed publisher
    ..Collectively, our data provide the first compelling evidence that caspase cleavage of ORF57 may represent a cellular function against lytic KSHV infection...
  15. Chen D, Choi Y, Sandford G, Nicholas J. Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6. J Virol. 2009;83:6874-82 pubmed publisher
    b>Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) is distinct from human and other cellular IL-6 proteins in that it does not require the nonsignaling alpha-receptor subunit for the formation of gp130-based signal transducing complexes ..
  16. Du M, Bacon C, Isaacson P. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders. J Clin Pathol. 2007;60:1350-7 pubmed
    Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), is a recent addition to the list of human viruses that are directly associated with lymphoproliferative disorders...
  17. Sherrill J, Miller W. Desensitization of herpesvirus-encoded G protein-coupled receptors. Life Sci. 2008;82:125-34 pubmed
    ..Here, we review what is currently known regarding viral GPCR desensitization and discuss potential biological ramifications of viral GPCR regulation by the host cell desensitization machinery...
  18. Majerciak V, Yamanegi K, Allemand E, Kruhlak M, Krainer A, Zheng Z. Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing. J Virol. 2008;82:2792-801 pubmed publisher
    ..Collectively our data indicate that KSHV ORF57 functions as a novel splicing factor in the spliceosome-mediated splicing of viral RNA transcripts...
  19. Zavitsanou A, Malliori M, Sypsa V, Petrodaskalaki M, Psichogiou M, Rokka C, et al. Seroepidemiology of human herpesvirus 8 (HHV-8) infection in injecting drug users. Epidemiol Infect. 2010;138:403-8 pubmed publisher
    ..study was carried out in injecting drug users (IDUs) from Greece to assess the seroprevalence of human herpesvirus 8 (HHV-8) and to identify potentially associated risk factors. A total of 288 IDUs were tested for K8...
  20. Tedeschi R, Marus A, Bidoli E, Simonelli C, De Paoli P. Human herpesvirus 8 DNA quantification in matched plasma and PBMCs samples of patients with HHV8-related lymphoproliferative diseases. J Clin Virol. 2008;43:255-9 pubmed publisher
    The quantitative evaluation of human herpesvirus 8 (HHV8) DNA is not well described in the clinical management of HHV8-related lymphoproliferative diseases.
  21. Sander G, Konrad A, Thurau M, Wies E, Leubert R, Kremmer E, et al. Intracellular localization map of human herpesvirus 8 proteins. J Virol. 2008;82:1908-22 pubmed
    b>Human herpesvirus 8 (HHV-8) is the etiological agent of Kaposi's sarcoma. We present a localization map of 85 HHV-8-encoded proteins in mammalian cells...
  22. Gottwein E, Mukherjee N, Sachse C, Frenzel C, Majoros W, Chi J, et al. A viral microRNA functions as an orthologue of cellular miR-155. Nature. 2007;450:1096-9 pubmed
    ..Moreover, the known aetiological role of miR-155 in B-cell transformation suggests that miR-K12-11 may contribute to the induction of KSHV-positive B-cell tumours in infected patients...
  23. Viviano E, Vitale F, Perna A, Cataldo F, Firenze A, Romano N. Human herpesvirus 8 seroprevalence among internationally adopted children coming from Eastern Europe. New Microbiol. 2009;32:11-5 pubmed
  24. Boulanger E, Meignin V, Oksenhendler E. Bortezomib (PS-341) in patients with human herpesvirus 8-associated primary effusion lymphoma. Br J Haematol. 2008;141:559-61 pubmed publisher
  25. Majerciak V, Zheng Z. Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing. Front Biosci (Landmark Ed). 2009;14:1516-28 pubmed
    ..Thus, some functions of ORF57 have been conserved while others have diverged from its homologues as ORF57 adapted over evolution to KSHV biology and pathogenesis...
  26. Fu B, Sun F, Li B, Yang L, Zeng Y, Sun X, et al. Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Xinjiang, China. J Med Virol. 2009;81:1422-31 pubmed publisher
    ..Geographic location, ethnicity, age and HIV-1 infection are risk factors. Serologic and genotyping results suggest the introduction of KSHV into Xinjiang by specific ethnic groups...
  27. Ganem D. KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu Rev Pathol. 2006;1:273-96 pubmed
    ..evidence has accumulated correlating infection with this KS-associated herpesvirus (KSHV, also known as human herpesvirus 8) with the development of the disease...
  28. Sakakibara S, Pise Masison C, Brady J, Tosato G. Gene regulation and functional alterations induced by Kaposi's sarcoma-associated herpesvirus-encoded ORFK13/vFLIP in endothelial cells. J Virol. 2009;83:2140-53 pubmed publisher
  29. Giuliani M, Cordiali Fei P, Castilletti C, Di Carlo A, Palamara G, Boros S, et al. Incidence of human herpesvirus 8 (HHV-8) infection among HIV-uninfected individuals at high risk for sexually transmitted infections. BMC Infect Dis. 2007;7:143 pubmed
    ..The objective of this study was to estimate the incidence and determinants of HHV-8 infection among HIV-uninfected individuals repeatedly attending an urban STI clinic...
  30. Choi Y, Nicholas J. Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines. J Virol. 2008;82:6501-13 pubmed publisher
    b>Human herpesvirus 8 (HHV-8), which is associated with the endothelial tumor Kaposi's sarcoma, encodes three CC/beta-chemokines...
  31. Thomas M, Boname J, Field S, Nejentsev S, Salio M, Cerundolo V, et al. Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity. Proc Natl Acad Sci U S A. 2008;105:1656-61 pubmed publisher
    ..The down-regulation of ligands for both the NKG2D and NKp80 activation pathways provides KSHV with a powerful mechanism for evasion of NK cell antiviral functions. ..
  32. Qu L, Jenkins F, Triulzi D. Human herpesvirus 8 genomes and seroprevalence in United States blood donors. Transfusion. 2010;50:1050-6 pubmed publisher
    b>Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus that causes Kaposi's sarcoma. The prevalence of HHV-8 genomes in US blood donors has not been systemically studied.
  33. Lebbe C, Legendre C, Frances C. Kaposi sarcoma in transplantation. Transplant Rev (Orlando). 2008;22:252-61 pubmed publisher
    Kaposi sarcoma (KS) is a multicentric neoplasm of lymphatic endothelium derived cells infected with Kaposi's human herpesvirus 8 (HHV8)...
  34. Rozen R, Sathish N, Li Y, Yuan Y. Virion-wide protein interactions of Kaposi's sarcoma-associated herpesvirus. J Virol. 2008;82:4742-50 pubmed publisher
  35. Tomlinson C, Damania B. Critical role for endocytosis in the regulation of signaling by the Kaposi's sarcoma-associated herpesvirus K1 protein. J Virol. 2008;82:6514-23 pubmed publisher
    ..When K1 internalization was examined in B lymphocytes, we found that K1 cointernalized with the BCR. Altogether, these results suggest that K1's signaling function is tightly coupled to its internalization...
  36. Campbell T, Borok M, Ndemera B, Fiorillo S, White I, Zhang X, et al. Lack of evidence for frequent heterosexual transmission of human herpesvirus 8 in Zimbabwe. Clin Infect Dis. 2009;48:1601-8 pubmed publisher
    There is conflicting evidence about the contribution of heterosexual transmission to the spread of human herpesvirus 8 (HHV-8) in southern Africa...
  37. Ganem D. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest. 2010;120:939-49 pubmed publisher
  38. Salata C, Curtarello M, Calistri A, Sartori E, Sette P, de Bernard M, et al. vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity. J Cell Physiol. 2009;219:698-706 pubmed publisher
    b>Human herpesvirus 8 (HHV-8) is a lymphotropic herpesvirus linked to several disorders such as Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease...
  39. Ye F, Zhou F, Xie J, Kang T, Greene W, Kuhne K, et al. Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latency. J Virol. 2008;82:4235-49 pubmed publisher
    ..Since the NF-kappaB pathway is commonly activated during infection of gammaherpesviruses, these findings might have general implications for the control of gammaherpesviral latency...
  40. Choi Y, Nicholas J. Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor. Virology. 2010;397:369-78 pubmed publisher
    b>Human herpesvirus 8 (HHV-8) is associated with Kaposi's sarcoma (KS), an endothelial cell lesion believed to be initiated and driven primarily by cytokine dysregulation...
  41. Rossetto C, Yamboliev I, Pari G. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesis. J Virol. 2009;83:8492-501 pubmed publisher
    The original cotransfection replication assay identified eight human herpesvirus 8 (HHV8)-encoded proteins required for origin-dependent lytic DNA replication...
  42. Liang C, Lee J, Jung J. Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis. Semin Cancer Biol. 2008;18:423-36 pubmed publisher
    ..Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), is etiologically linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL)..
  43. Orzechowska B, Powers M, Sprague J, Li H, Yen B, Searles R, et al. Rhesus macaque rhadinovirus-associated non-Hodgkin lymphoma: animal model for KSHV-associated malignancies. Blood. 2008;112:4227-34 pubmed publisher
    ..These data support the utility of the RRV-/SIV-infected RM as an excellent animal model to investigate KSHV-like pathogenesis...
  44. Casper C, Krantz E, Corey L, Kuntz S, Wang J, Selke S, et al. Valganciclovir for suppression of human herpesvirus-8 replication: a randomized, double-blind, placebo-controlled, crossover trial. J Infect Dis. 2008;198:23-30 pubmed publisher
    ..In vitro and observational studies suggest that ganciclovir inhibits HHV-8 replication, but no randomized clinical trials have been conducted...
  45. Guihot A, Oksenhendler E, Galicier L, Marcelin A, Papagno L, Bedin A, et al. Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells. Blood. 2008;111:1387-95 pubmed
    Multicentric Castleman disease (MCD) is a devastating human herpesvirus 8 (HHV-8)-related lymphoproliferative disorder that occurs in immunocompromised persons...
  46. Konrad A, Wies E, Thurau M, Marquardt G, Naschberger E, Hentschel S, et al. A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-kappaB activation. J Virol. 2009;83:2563-74 pubmed publisher
    b>Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma and primary effusion lymphoma...
  47. Guanira J, Casper C, Lama J, Morrow R, Montano S, Caballero P, et al. Prevalence and correlates of human herpesvirus 8 infection among Peruvian men who have sex with men. J Acquir Immune Defic Syndr. 2008;49:557-62 pubmed publisher
    Infection with human herpesvirus 8 (HHV-8) is common among men who have sex with men (MSM) in North America and Europe and is also found to be endemic in some regions of South America...
  48. Conrad N. Posttranscriptional gene regulation in Kaposi's sarcoma-associated herpesvirus. Adv Appl Microbiol. 2009;68:241-61 pubmed publisher
    ..With the growing appreciation of posttranscriptional regulation in cellular gene expression, it seems likely that the list of viral posttranscriptional regulatory schemes will expand as new details of KSHV gene regulation are uncovered...
  49. Barcy S, De Rosa S, Vieira J, Diem K, Ikoma M, Casper C, et al. Gamma delta+ T cells involvement in viral immune control of chronic human herpesvirus 8 infection. J Immunol. 2008;180:3417-25 pubmed
    Little is known about what effector populations are associated with the control of human herpesvirus 8 (HHV-8) infection in vivo. We compared T lymphocyte subsets among HIV-HHV-8+ and HIV-HHV-8- infected human individuals...
  50. Barozzi P, Bonini C, Potenza L, Masetti M, Cappelli G, Gruarin P, et al. Changes in the immune responses against human herpesvirus-8 in the disease course of posttransplant Kaposi sarcoma. Transplantation. 2008;86:738-44 pubmed publisher
    ..HHV-8-specific T-cell responses are required to achieve posttransplant KS remission, and may be restored under SRL, while maintaining effective immunosuppression...
  51. Kreuter A, Bischoff S, Skrygan M, Wieland U, Brockmeyer N, Stucker M, et al. High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides. Arch Dermatol. 2008;144:1011-6 pubmed publisher
    To investigate the presence of human herpesvirus 8 (HHV-8) in lesional skin of German patients with large-plaque parapsoriasis (LPP) or mycosis fungoides (MF)...
  52. Batista M, Ferreira S, Sauer M, Tomiyama H, Giret M, Pannuti C, et al. High human herpesvirus 8 (HHV-8) prevalence, clinical correlates and high incidence among recently HIV-1-infected subjects in Sao Paulo, Brazil. PLoS ONE. 2009;4:e5613 pubmed publisher
    b>Human herpesvirus 8 (HHV-8) is the etiological agent for Kaposi Sarcoma, which occurs especially in HIV-infected subjects...
  53. Biryahwaho B, Dollard S, Pfeiffer R, Shebl F, Munuo S, Amin M, et al. Sex and geographic patterns of human herpesvirus 8 infection in a nationally representative population?based sample in Uganda. J Infect Dis. 2010;202:1347-53 pubmed publisher
    b>Human herpesvirus 8 (HHV8), the infectious cause of Kaposi sarcoma, varies dramatically across Africa, suggesting that cofactors correlated with large-area geographic or environmental characteristics may influence risk of infection...
  54. Potthoff A, Brockmeyer N. HIV-associated Kaposi sarcoma: pathogenesis and therapy. J Dtsch Dermatol Ges. 2007;5:1091-4 pubmed
    ..In 45 % of patients with more than 400/microl CD4+ lymphocytes, interferon-alpha induces complete remission. New concepts of pathogenesis lead to therapeutic targets, such as inhibition of angiogenesis...
  55. Zhao J, Punj V, Matta H, Mazzacurati L, Schamus S, Yang Y, et al. K13 blocks KSHV lytic replication and deregulates vIL6 and hIL6 expression: a model of lytic replication induced clonal selection in viral oncogenesis. PLoS ONE. 2007;2:e1067 pubmed
    ..However, the molecular events leading to the dysregulation of KSHV lytic gene expression program are incompletely understood...
  56. Minami R, Yamamoto M, Takahama S, Ando H, Miyamura T, Suematsu E. Human herpesvirus 8 DNA load in the leukocytes correlates with the platelet counts in HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 2009;25:1-8 pubmed publisher
    ..This may be one of the mechanisms by which HHV-8 infection induces thrombocytopenia. These results indicate that HHV-8 DNA in leukocytes may provide useful information for the assessment of the clinical appearance of HIV-1 infection...
  57. Xie J, Ajibade A, Ye F, Kuhne K, Gao S. Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathways. Virology. 2008;371:139-54 pubmed
    ..Together, these findings suggest that MAPK pathways might have general roles in regulating the life cycle of KSHV by mediating both viral infection and switch from viral latency to lytic replication...
  58. Mansouri M, Rose P, Moses A, Fruh K. Remodeling of endothelial adherens junctions by Kaposi's sarcoma-associated herpesvirus. J Virol. 2008;82:9615-28 pubmed publisher
  59. Laurent C, Meggetto F, Brousset P. Human herpesvirus 8 infections in patients with immunodeficiencies. Hum Pathol. 2008;39:983-93 pubmed publisher
    ..herpesvirus in tissues from patients with Kaposi sarcoma, referred to as Kaposi sarcoma herpesvirus or human herpesvirus 8. They used a very sophisticated technique of molecular biology to isolate unknown DNA sequences from Kaposi ..
  60. Matta H, Punj V, Schamus S, Mazzacurati L, Chen A, Song R, et al. A nuclear role for Kaposi's sarcoma-associated herpesvirus-encoded K13 protein in gene regulation. Oncogene. 2008;27:5243-53 pubmed publisher
  61. Nachmani D, Stern Ginossar N, Sarid R, Mandelboim O. Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells. Cell Host Microbe. 2009;5:376-85 pubmed publisher
    ..The finding that different herpesvirus microRNAs target MICB indicates that MICB plays a pivotal role in the clash between herpesviruses and humans...
  62. Yang T, Chang C, Lan Y, Liu C, Shih M, Wu F, et al. Recombinant ORF66 and ORFK12 antigens for the detection of human herpesvirus 8 antibodies in HIV-positive and -negative patients. Biotechnol Lett. 2009;31:629-37 pubmed publisher
    b>Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), is not routinely isolated in cell cultures, and thus detection of HHV-8-specific antibodies is usually performed...
  63. Mansouri M, Viswanathan K, Douglas J, Hines J, Gustin J, Moses A, et al. Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. J Virol. 2009;83:9672-81 pubmed publisher
    ..We further demonstrate that KSHV release is decreased in the absence of K5 in a BST2-dependent manner, suggesting that K5 contributes to the evasion of intracellular antiviral defense programs...
  64. Veettil M, Sadagopan S, Sharma Walia N, Wang F, Raghu H, Varga L, et al. Kaposi's sarcoma-associated herpesvirus forms a multimolecular complex of integrins (alphaVbeta5, alphaVbeta3, and alpha3beta1) and CD98-xCT during infection of human dermal microvascular endothelial cells, and CD98-xCT is essential for the postentry. J Virol. 2008;82:12126-44 pubmed publisher
  65. Caselli E, Galvan M, Santoni F, Alvarez S, de Lera A, Ivanova D, et al. Retinoic acid analogues inhibit human herpesvirus 8 replication. Antivir Ther. 2008;13:199-209 pubmed
    Retinoids have a pronounced antiviral effect against several viruses. In this study we aimed to investigate the effect of retinoids on human herpesvirus 8 (HHV-8).
  66. Borok M, Fiorillo S, Gudza I, Putnam B, Ndemera B, White I, et al. Evaluation of plasma human herpesvirus 8 DNA as a marker of clinical outcomes during antiretroviral therapy for AIDS-related Kaposi sarcoma in Zimbabwe. Clin Infect Dis. 2010;51:342-9 pubmed publisher
    The usefulness of plasma human herpesvirus 8 (HHV-8) DNA as a marker of response to treatment for acquired immunodeficiency syndrome-associated Kaposi sarcoma (AIDS-KS) in an African setting is unknown.
  67. Sobngwi E, Choukem S, Agbalika F, Blondeau B, Fetita L, Lebbe C, et al. Ketosis-prone type 2 diabetes mellitus and human herpesvirus 8 infection in sub-saharan africans. JAMA. 2008;299:2770-6 pubmed publisher
    ..Its sudden onset suggests precipitating factors...
  68. Chen D, Sandford G, Nicholas J. Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6. J Virol. 2009;83:722-33 pubmed publisher
    b>Human herpesvirus 8 (HHV-8)-encoded viral interleukin-6 (vIL-6) has been implicated as a key factor in virus-associated neoplasia because of its proproliferative and survival effects and also in view of its angiogenic properties...
  69. Dollard S, Butler L, Jones A, Mermin J, Chidzonga M, Chipato T, et al. Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt". Int J Cancer. 2010;127:2395-401 pubmed publisher
    ..These findings help to explain the high KS incidence in the "KS Belt" and underscore the importance of a uniform approach to HHV-8 antibody testing...
  70. Mbulaiteye S, Pfeiffer R, Dolan B, Tsang V, Noh J, Mikhail N, et al. Seroprevalence and risk factors for human herpesvirus 8 infection, rural Egypt. Emerg Infect Dis. 2008;14:586-91 pubmed publisher
    To determine whether human herpesvirus 8 (HHV-8) is associated with schistosomal and hepatitis C virus infections in Egypt, we surveyed 965 rural household participants who had been tested for HHV-8 and schistosomal infection (..
  71. Chen J, Ye F, Xie J, Kuhne K, Gao S. Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA. Virology. 2009;386:290-302 pubmed publisher
    ..These results suggest the complexity of RTA binding in vivo, and the involvement of other cellular or viral transcription factors during RTA transactivation of target genes...
  72. Ellison T, Izumiya Y, Izumiya C, Luciw P, Kung H. A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus. Virology. 2009;387:76-88 pubmed publisher
    ..This study provides a comprehensive overview of the responsiveness of KSHV promoters to K-Rta and K-bZIP, and describes key chromatin changes during viral reactivation...