fowl adenovirus a

Summary

Summary: The type species of the genus AVIADENOVIRUS, family ADENOVIRIDAE, an oncogenic virus of birds. This is also called CELO virus for chick embryo lethal orphan virus.

Top Publications

  1. Marek A, Schulz E, Hess C, Hess M. Comparison of the fibers of Fowl adenovirus A serotype 1 isolates from chickens with gizzard erosions in Europe and apathogenic reference strains. J Vet Diagn Invest. 2010;22:937-41 pubmed
    ..Fowl adenoviruses were found in samples from all 4 outbreaks, and isolates were identified as Fowl adenovirus A (FAdV-A) serotype 1...
  2. Parthiban M, Manoharan S, Aruni A, Prabhakar T, Chandran N, Koteeswaran A. Usefulness of polymerase chain reaction in early detection and tissue tropism of fowl adenovirus in experimentally infected chicken. Vet Res Commun. 2004;28:617-22 pubmed
  3. Xu L, Benson S, Burnett R. Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon. J Struct Biol. 2007;157:424-31 pubmed
    ..Structural studies on CELO will elucidate the differences between avian and human adenoviruses and contribute to a better understanding of adenoviruses with non-human hosts...
  4. Singh A, Bekele A, Patnayak D, Jindal N, Porter R, Mor S, et al. Molecular characterization of quail bronchitis virus isolated from bobwhite quail in Minnesota. Poult Sci. 2016;95:2815-2818 pubmed
    ..Nucleotide sequences of the four isolates showed 99.0% identity with CELO strain of fowl adenovirus A. Nine nucleotide substitutions were observed; 3 of these were nonsynonymous (A281G, C314T and G565C), ..
  5. Nakamura K, Ohyama T, Saito A, Yamada M, Imada T, Mase M. Gizzard nematodiasis in Japanese mountain hawk eagle (Spizaetus nipalensis). Avian Dis. 2001;45:751-4 pubmed
    ..The morphology suggests that the parasites may be nematodes, but the species of nematode could not be confirmed. The bird may have died from malabsorption and respiratory damage as a result of the gizzard and lung lesions...
  6. Lim T, Kim B, Kim M, Jang J, Lee D, Kwon Y, et al. Outbreak of gizzard erosion associated with fowl adenovirus infection in Korea. Poult Sci. 2012;91:1113-7 pubmed publisher
    ..These findings provide important information on the epidemiology and pathogenesis of FAdV-1 infection in chickens...
  7. Schonewille E, Jaspers R, Paul G, Hess M. Specific-pathogen-free chickens vaccinated with a live FAdV-4 vaccine are fully protected against a severe challenge even in the absence of neutralizing antibodies. Avian Dis. 2010;54:905-10 pubmed
    ..Altogether, the present investigation underlines that neutralizing antibodies are not needed to protect chickens against a severe infection with a virulent fowl adenovirus...
  8. Cherenova L, Logunov D, Shashkova E, Shmarov M, Verkhovskaya L, Neugodova G, et al. Recombinant avian adenovirus CELO expressing the human interleukin-2: characterization in vitro, in ovo and in vivo. Virus Res. 2004;100:257-61 pubmed
    ..An increase in the median survival time of C57BL/6 mice carrying B16 melanoma tumors has been demonstrated after multiple intra-tumors injections of the recombinant adenovirus CELO-IL2...
  9. Balamurugan V, Kataria J, Kataria R, Verma K, Nanthakumar T. Characterization of fowl adenovirus serotype-4 associated with hydropericardium syndrome in chicken. Comp Immunol Microbiol Infect Dis. 2002;25:139-47 pubmed
    ..2 kDa protein. Subsequent immunoblotting showed relatedness of at least five protein fractions of FAV-4 to CELO virus...

More Information

Publications54

  1. Günes A, Marek A, Grafl B, Berger E, Hess M. Real-time PCR assay for universal detection and quantitation of all five species of fowl adenoviruses (FAdV-A to FAdV-E). J Virol Methods. 2012;183:147-53 pubmed publisher
    ..The real-time PCR was found more sensitive than cell culture and conventional PCR. Detection and quantitation of FAdVs in different type of samples was possible by the new real-time PCR...
  2. Zavala G, Dufour Zavala L, Villegas P, El Attrache J, Hilt D, Jackwood M. Lack of interaction between avian leukosis virus subgroup J and fowl adenovirus (FAV) in FAV-antibody-positive chickens. Avian Dis. 2002;46:979-84 pubmed
    ..With such criteria for evaluating possible interactions, we found no significant differences in the dually infected birds in comparison with chickens that received a monovalent challenge with either FAV or ALV-J...
  3. Sun J, Li Q, Li Y, Huang B, Song M, Li X. [Identification of a non-essential region for replication of fowl adenovirus QU strain]. Sheng Wu Gong Cheng Xue Bao. 2008;24:1263-7 pubmed
    ..The work lays the foundation for further studies of developing this virus as a vector of recombinant vaccine...
  4. Ono M, Okuda Y, Shibata I, Sato S, Okada K. Pathogenicity by parenteral injection of fowl adenovirus isolated from gizzard erosion and resistance to reinfection in adenoviral gizzard erosion in chickens. Vet Pathol. 2004;41:483-9 pubmed
    ..Moreover, FAV was not recovered from the gizzard or rectum of any of the chickens at necropsy. This suggests that the gizzard lesions occurred as a result of the primary infection, and that the chickens were able to resist reinfection...
  5. Philippe C, Grgić H, Ojkic D, Nagy E. Serologic monitoring of a broiler breeder flock previously affected by inclusion body hepatitis and testing of the progeny for vertical transmission of fowl adenoviruses. Can J Vet Res. 2007;71:98-102 pubmed
    ..The lack of virus production and transmission could be due to the presence of high antibody titers in the layers...
  6. Boggio R, Passafaro A, Chiocca S. Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation. J Biol Chem. 2007;282:15376-82 pubmed
    ..These results reveal the mechanism by which a viral protein inactivates and subsequently degrades an essential cellular enzyme, arresting a key regulatory pathway...
  7. Muroga N, Taharaguchi S, Ohta H, Yamazaki K, Takase K. Pathogenicity of fowl adenovirus isolated from gizzard erosions to immuno-suppressed chickens. J Vet Med Sci. 2006;68:289-91 pubmed
    ..There were no gross lesions in any other organs except for bursal atrophy. Serologically, antibody production against FAV was highly suppressed by IBDV infection or CY treatment...
  8. El Attrache J, Villegas P, O CONNOR B, Buhr J, Rowland G. Adenovirus pathogenicity in immature ostriches. Avian Dis. 2001;45:442-6 pubmed
    ..These viruses were identified by virus neutralization and further characterized by a pathogenicity trial in immature ostriches. The results showed that these isolates were noninfectious in ostrich chicks...
  9. Shivachandra S, Sah R, Singh S, Kataria J, Manimaran K. Immunosuppression in broiler chicks fed aflatoxin and inoculated with fowl adenovirus serotype-4 (FAV-4) associated with hydropericardium syndrome. Vet Res Commun. 2003;27:39-51 pubmed
    ..Microscopically, marked depletion and degeneration of lymphocytes in the thymus, bursa, spleen and caecal tonsils were observed in group AV up to 5 weeks PI...
  10. Marek A, Günes A, Schulz E, Hess M. Classification of fowl adenoviruses by use of phylogenetic analysis and high-resolution melting-curve analysis of the hexon L1 gene region. J Virol Methods. 2010;170:147-54 pubmed publisher
    ..Gaining of hexon sequences of further field isolates offers the potential for novel and additional information in analysis of the molecular epidemiology of FAdV...
  11. Barra C, Langlois P. First step in characterization of cis-acting sequences involved in fowl adenovirus 1 (CELO) packaging and its effect on the development of a helper-dependent vector strategy. Virus Genes. 2009;38:46-55 pubmed publisher
    ..We also showed that the loxP-flanked region was efficiently removed in a Cre expressing cell line to produce a candidate helper virus...
  12. Rademaker H, Fallaux F, van den Wollenberg D, de Jong R, van der Vliet P, Hoeben R. Relaxed template specificity in fowl adenovirus 1 DNA replication initiation. J Gen Virol. 2006;87:553-62 pubmed
    ..This was evident from the appearance of DpnI-resistant fragments in a minireplicon assay. From these data, it is concluded that FAdV-1 has relaxed, rather than changed, its template specificity at replication initiation...
  13. Francois A, Chevalier C, Delmas B, Eterradossi N, Toquin D, Rivallan G, et al. Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens. Vaccine. 2004;22:2351-60 pubmed
    ..These results indicate that CELO-based vectors are useful to safely induce a strong protective immunity against vvIBDV in chickens...
  14. Le Goff F, Méderlé Mangeot I, Jestin A, Langlois P. Deletion of open reading frames 9, 10 and 11 from the avian adenovirus CELO genome: effect on biodistribution and humoral responses. J Gen Virol. 2005;86:2019-27 pubmed
    ..Nevertheless, the presence of antibodies directed to heterologous antigens makes the CELO virus an advantageous candidate for avian vaccination...
  15. Domanska Blicharz K, Tomczyk G, Smietanka K, Kozaczynski W, Minta Z. Molecular characterization of fowl adenoviruses isolated from chickens with gizzard erosions. Poult Sci. 2011;90:983-9 pubmed publisher
    ..Although short and long proteins were indicated as factors influencing virus pathogenicity, the role of identified sequence differences in infectivity determination remain unclear...
  16. Okuda Y, Ono M, Yazawa S, Imai Y, Shibata I, Sato S. Pathogenicity of serotype 1 fowl adenovirus in commercial broiler chickens. Avian Dis. 2001;45:819-27 pubmed
  17. Choi K, Kye S, Kim J, Jeon W, Lee E, Park K, et al. Epidemiological investigation of outbreaks of fowl adenovirus infection in commercial chickens in Korea. Poult Sci. 2012;91:2502-6 pubmed
    ..1%. Chicken infectious anemia virus was detected in all native chicken cases. These results indicate that preventive measures against FAdV infection and immunosuppressive diseases on poultry farms should be implemented...
  18. Singh A, Grewal G, Maiti N, Oberoi M. Effect of fowl adenovirus-1 (IBH isolate) on humoral and cellular immune competency of broiler chicks. Comp Immunol Microbiol Infect Dis. 2006;29:315-21 pubmed
    ..These results indicated that FAV-1 affects humoral as well as cellular immune competency of infected chicks...
  19. Schachner A, Marek A, Jaskulska B, Bilic I, Hess M. Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis-hydropericardium syndrome (HHS). Vaccine. 2014;32:1086-92 pubmed publisher
    ..In conclusion, recombinant fiber-2 was identified as a protective immunogen and is proposed as an attractive candidate for a subunit vaccine to prevent hepatitis-hydropericardium syndrome in chickens. ..
  20. Guardado Calvo P, Llamas Saiz A, Langlois P, van Raaij M. Crystallization of the C-terminal head domain of the avian adenovirus CELO long fibre. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:449-52 pubmed
    ..However, a map calculated using SIRAS phasing shows a clear trimer with a shape similar to known adenovirus fibre-head structures. Structure solution is in progress...
  21. Taharaguchi S, Ito H, Ohta H, Takase K. Characterization of monoclonal antibodies against fowl adenovirus serotype 1 (FAV1) isolated from gizzard erosion. Avian Dis. 2006;50:331-5 pubmed
    ..These Mabs will be useful for immunodiagnosis of FAV serotype 1 infection in chickens with gizzard erosion and in further research studies involving the genomes and proteins of FAV serotype 1...
  22. Rauw F, Lambrecht B, Francois A, Langlois P, van den Berg T. Kinetic and biologic properties of recombinant ChIFN-gamma expressed via CELO-virus vector. J Interferon Cytokine Res. 2007;27:111-8 pubmed
    ..Therefore, the CELO-virus expression system is an appropriate system for high-level expression of biologically active and stable ChIFN-gamma...
  23. Schade B, Schmitt F, Böhm B, Alex M, Fux R, Cattoli G, et al. Adenoviral gizzard erosion in broiler chickens in Germany. Avian Dis. 2013;57:159-63 pubmed
    ..Previously several outbreaks of gizzard erosions caused by a fowl adenovirus A serotype-1 (FAdV-1) were reported from Japan...
  24. Logunov D, Zubkova O, Karyagina Zhulina A, Shuvalova E, Karpov A, Shmarov M, et al. Identification of HI-like loop in CELO adenovirus fiber for incorporation of receptor binding motifs. J Virol. 2007;81:9641-52 pubmed
    ..These results illustrate the potential for efficient CELO-mediated gene transfer into a broad range of cell types through modification of the identified HI-like loop of the fiber 1 protein...
  25. Schonewille E, Singh A, Göbel T, Gerner W, Saalmuller A, Hess M. Fowl adenovirus (FAdV) serotype 4 causes depletion of B and T cells in lymphoid organs in specific pathogen-free chickens following experimental infection. Vet Immunol Immunopathol. 2008;121:130-9 pubmed
    ..The effects are much more severe in the birds infected with the virulent virus only indicating that the preceding infection with the attenuated virus reduces significantly the adverse effects induced by the virulent virus...
  26. Corredor J, Nagy E. Antibody response and virus shedding of chickens inoculated with left end deleted fowl adenovirus 9-based recombinant viruses. Avian Dis. 2011;55:443-6 pubmed
    ..In this work, we demonstrated the potential of FAdV-9-based recombinant viruses as vaccines for poultry...
  27. Balamurugan V, Kataria J. Economically important non-oncogenic immunosuppressive viral diseases of chicken--current status. Vet Res Commun. 2006;30:541-66 pubmed
    ..The mechanism of immunosuppression has been studied in detail for certain chicken viruses at molecular levels, which will provides new opportunities to control these diseases by vaccination...
  28. Ganesh K, Suryanarayana V, Raghavan R. Detection of fowl adenovirus associated with hydropericardium hepatitis syndrome by a polymerase chain reaction. Vet Res Commun. 2002;26:73-80 pubmed
    ..Amplification of the specific product could be obtained not only from the DNA isolated from the purified virus but also from the total DNA extracted from infected tissues. The PCR was useful for the detection of FAV associated with HHS...
  29. Ojkic D, Nagy E. Antibody response and virus tissue distribution in chickens inoculated with wild-type and recombinant fowl adenoviruses. Vaccine. 2003;22:42-8 pubmed
    ..Based on these results the TR-2 was dispensable for viral replication in vivo and did not influence virus distribution, and the recombinant FAdV-9 induced the same immune response as the wild-type virus...
  30. Griffin B, Nagy E. Coding potential and transcript analysis of fowl adenovirus 4: insight into upstream ORFs as common sequence features in adenoviral transcripts. J Gen Virol. 2011;92:1260-72 pubmed publisher
  31. Gowthaman V, Singh S, Dhama K, Barathidasan R, Kumar M, Desingu P, et al. Fowl adenovirus (FAdV) in India: evidence for emerging role as primary respiratory pathogen in chickens. Pak J Biol Sci. 2012;15:900-3 pubmed
    ..The findings of the study assert that FAdV can play the role of primary respiratory pathogen in immunocompromised birds and also in the presence of other respiratory pathogens...
  32. Shashkova E, Cherenova L, Kazansky D, Doronin K. Avian adenovirus vector CELO-TK displays anticancer activity in human cancer cells and suppresses established murine melanoma tumors. Cancer Gene Ther. 2005;12:617-26 pubmed
    ..The results of the study demonstrated the efficacy of CELO vector as a vehicle for the delivery of prodrug-activating genes such as HSV-tk to tumor cells in vitro and in vivo...
  33. Washietl S, Eisenhaber F. Reannotation of the CELO genome characterizes a set of previously unassigned open reading frames and points to novel modes of host interaction in avian adenoviruses. BMC Bioinformatics. 2003;4:55 pubmed
    ..We conducted a systematic reannotation and in-depth sequence analysis of the CELO genome...
  34. Ono M, Okuda Y, Yazawa S, Imai Y, Shibata I, Sato S, et al. Adenoviral gizzard erosion in commercial broiler chickens. Vet Pathol. 2003;40:294-303 pubmed
    ..Thus, this study shows that FAV-99ZH causes adenoviral gizzard erosion in broiler chickens without hepatic or pancreatic lesions and that cell infiltration is more severe than in dietary gizzard erosions...
  35. Ojkic D, Krell P, Tuboly T, Nagy E. Characterization of fowl adenoviruses isolated in Ontario and Quebec, Canada. Can J Vet Res. 2008;72:236-41 pubmed
    ..The number of serotype 8 virus isolations has increased over the years, and by 2001 serotype 8 had become the dominant serotype in Ontario, and continues to be so. Moreover, this virus (FAdV-8) has shown a strong association with IBH...
  36. Okuda Y, Ono M, Shibata I, Sato S, Akashi H. Comparison of the polymerase chain reaction-restriction fragment length polymorphism pattern of the fiber gene and pathogenicity of serotype-1 fowl adenovirus isolates from gizzard erosions and from feces of clinically healthy chickens in Japan. J Vet Diagn Invest. 2006;18:162-7 pubmed
    ..Use of PCR-RFLP analysis of long fiber genes may be able to distinguish between these two strains...
  37. Jadhao S, Deepak J, Kataria J, Kataria R, Tiwari A, Somvanshi R, et al. Characterisation of fowl adenoviruses from chickens affected with infectious hydropericardium during 1994-1998 in India. Indian J Exp Biol. 2003;41:321-7 pubmed
  38. El Bakkouri M, Seiradake E, Cusack S, Ruigrok R, Schoehn G. Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre. Virology. 2008;378:169-76 pubmed publisher
    ..Both the fibre head sequence and structural alignments suggest that enteric human group F adenovirus 41 (short fibre) is closer to the CELO fibre heads than the canine CAdV-2 fibre head, that lies closer to the human virus fibre heads...
  39. Guardado Calvo P, Llamas Saiz A, Fox G, Langlois P, van Raaij M. Structure of the C-terminal head domain of the fowl adenovirus type 1 long fiber. J Gen Virol. 2007;88:2407-16 pubmed
  40. Grgić H, Philippe C, Ojkic D, Nagy E. Study of vertical transmission of fowl adenoviruses. Can J Vet Res. 2006;70:230-3 pubmed
    ..No fowl adenoviruses were isolated in chicken hepatoma cells from any of the 30 samples inoculated. These findings imply that vertical transmission and establishment of latent infection with FAdVs can occur in chickens...
  41. Gjevre A, Kaldhusdal M, Eriksen G. Gizzard erosion and ulceration syndrome in chickens and turkeys: a review of causal or predisposing factors. Avian Pathol. 2013;42:297-303 pubmed publisher
    ..During the last decades, serotype 1 of fowl adenovirus A and Clostridium perfringens have been implicated as important pathogenic agents in the development of GEU in ..
  42. Corredor J, Krell P, Nagy E. Sequence analysis of the left end of fowl adenovirus genomes. Virus Genes. 2006;33:95-106 pubmed
    ..However, ORF 1C was absent in FAdV-4 and -10, but additional ORFs, most likely corresponding to duplicates of ORF 14, were observed in these viruses...
  43. Stevenson M, Boos E, Herbert C, Hale A, Green N, Lyons M, et al. Chick embryo lethal orphan virus can be polymer-coated and retargeted to infect mammalian cells. Gene Ther. 2006;13:356-68 pubmed
    ..The data indicate that CELO virus may be retargeted to infect human cells via alternative, potentially disease-specific, receptors and resist the effects of pre-existing humoral immunity...
  44. Senthilkumar N, Kataria J, Koti M, Dhama K, Dash B. Restriction enzyme analysis of Indian isolates of egg drop syndrome 1976 virus recovered from chicken, duck and quail. Vet Res Commun. 2004;28:447-53 pubmed
    ..All other isolates were identical to the reference viral strain BC-14, which belong to group I of EDS-76 viruses. The duck isolate EDS-KC could not be placed in any of the three groups reported earlier...
  45. Ono M, Okuda Y, Shibata I, Sato S, Okada K. Reproduction of adenoviral gizzard erosion by the horizontal transmission of fowl adenovirus serotype 1. J Vet Med Sci. 2007;69:1005-8 pubmed
    ..We conclude that FAV-99ZH strain spreads rapidly through direct contact with inoculated chickens, and slowly through non-contact transmission, and that adenoviral gizzard erosion is reproduced by this horizontal transmission...