satellite viruses


Summary: Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.

Top Publications

  1. Ng P, Parks R, Graham F. Preparation of helper-dependent adenoviral vectors. Methods Mol Med. 2002;69:371-88 pubmed
  2. Shih S, Kumar S, Tsai W, Lee L, Green S. Complete nucleotide sequences of okra isolates of Cotton leaf curl Gezira virus and their associated DNA-beta from Niger. Arch Virol. 2009;154:369-72 pubmed publisher
    ..The begomovirus and DNA-beta have been identified as Cotton leaf curl Gezira virus and Cotton leaf curl Gezira betasatellite, respectively, which are reported to also infect okra in Egypt, Mali and Sudan...
  3. Nawaz ul Rehman M, Fauquet C. Evolution of geminiviruses and their satellites. FEBS Lett. 2009;583:1825-32 pubmed publisher
    ..The greatest molecular diversity of geminiviruses and their satellites resides in Southeast Asia revealing a possible center of origin. This minireview leads us to a possible general grand scheme of their evolution...
  4. Amrao L, Akhter S, Tahir M, Amin I, Briddon R, Mansoor S. Cotton leaf curl disease in Sindh province of Pakistan is associated with recombinant begomovirus components. Virus Res. 2010;153:161-5 pubmed publisher
    ..These results indicate that the virus complex causing CLCuD in Sindh is distinct from that in the adjacent Punjab province. Possible reasons for these differences are discussed...
  5. Amin I, Hussain K, Akbergenov R, Yadav J, Qazi J, Mansoor S, et al. Suppressors of RNA silencing encoded by the components of the cotton leaf curl begomovirus-betasatellite complex. Mol Plant Microbe Interact. 2011;24:973-83 pubmed publisher
  6. Krupovic M, Cvirkaite Krupovic V. Virophages or satellite viruses?. Nat Rev Microbiol. 2011;9:762-3 pubmed
    ..However, Mart Krupovic and Virginija Cvirkaite-Krupovic argue here that these smaller viruses should be classified with the satellite viruses.
  7. Ban N, Larson S, McPherson A. Structural comparison of the plant satellite viruses. Virology. 1995;214:571-83 pubmed
    Detailed structures are now available for three plant satellite viruses, satellite tobacco necrosis virus (STNV), satellite tobacco mosaic virus (STMV), and satellite panicum mosaic virus (SPMV)...
  8. Routhier E, Bruenn J. Functions of conserved motifs in the RNA-dependent RNA polymerase of a yeast double-stranded RNA virus. J Virol. 1998;72:4427-9 pubmed
    ..The results help define the conserved regions of the RDRP involved in polymerase function and those essential for other reasons...
  9. Hussain K, Hussain M, Mansoor S, Briddon R. Complete nucleotide sequence of a begomovirus and associated betasatellite infecting croton (Croton bonplandianus) in Pakistan. Arch Virol. 2011;156:1101-5 pubmed publisher
    ..For the begomovirus, an analysis of the sequence indicates that it has a recombinant origin...

More Information

Publications116 found, 100 shown here

  1. Halder S, Van Vliet K, Smith J, Duong T, McKenna R, Wilson J, et al. Structure of neurotropic adeno-associated virus AAVrh.8. J Struct Biol. 2015;192:21-36 pubmed publisher
    ..These features are essential for the creation of an AAV vector toolkit that is amenable to personalized disease treatment. ..
  2. Cahoon J, Rai R, Carroll L, Uehara H, Zhang X, O Neil C, et al. Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy. Diabetes. 2015;64:4247-59 pubmed publisher
    ..AAV2.COMP-Ang1 single-dose gene therapy can prevent neurovascular pathology, support vascular regeneration, and stabilize vision in DR. ..
  3. Gil Farina I, Di Scala M, Salido E, Lopez Franco E, Rodríguez Garcia E, Blasi M, et al. Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis. J Immunol. 2016;197:2145-56 pubmed publisher
    ..This model provides a practical tool to explore AIH pathogenesis and novel therapies. ..
  4. Zhou B, Lei S, Xue R, Leng Y, Xia Z, Xia Z. DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy. Clin Sci (Lond). 2017;131:1161-1178 pubmed publisher
    ..Thus, decreased cardiac DJ-1 expression, which results in impaired AMPK/mTOR signalling and decreased autophagy, could be a major mechanism underlying the loss of IPO-induced cardioprotection in diabetes. ..
  5. Franzoso F, Seyffert M, Vogel R, Yakimovich A, de Andrade Pereira B, Meier A, et al. Cell Cycle-Dependent Expression of Adeno-Associated Virus 2 (AAV2) Rep in Coinfections with Herpes Simplex Virus 1 (HSV-1) Gives Rise to a Mosaic of Cells Replicating either AAV2 or HSV-1. J Virol. 2017;91: pubmed publisher
    ..Conversely, low Rep protein levels in G1 phase permit HSV-1 replication but are insufficient for AAV2 replication. This allows both viruses to productively replicate in distinct sets of dividing cells. ..
  6. Saiki H, Moulay G, Guenzel A, Liu W, Decklever T, Classic K, et al. Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2017;313:H392-H407 pubmed publisher
  7. Baruteau J, Waddington S, Alexander I, Gissen P. Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects. J Inherit Metab Dis. 2017;40:497-517 pubmed publisher
    ..There is clearly an urgent need for more efficient therapies in many severe monogenic liver disorders, which will require careful risk-benefit analysis for each indication, especially in paediatrics. ..
  8. Liu Y, Zhao M, Gong M, Xu Y, Xie C, Deng H, et al. Inhibition of hepatitis B virus replication via HBV DNA cleavage by Cas9 from Staphylococcus aureus. Antiviral Res. 2018;152:58-67 pubmed publisher
    ..The system was delivered by an AAV vector and maybe used as a novel therapeutic strategy against chronic HBV infection. ..
  9. Rezvani M, Español Suñer R, Malato Y, Dumont L, Grimm A, Kienle E, et al. In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis. Cell Stem Cell. 2016;18:809-16 pubmed publisher
    ..Because AAV vectors are already used for liver-directed human gene therapy, our strategy has potential for clinical translation into a therapy for liver fibrosis. ..
  10. Dissen G, Adachi K, Lomniczi A, Chatkupt T, Davidson B, Nakai H, et al. Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update. Reprod Domest Anim. 2017;52 Suppl 2:354-358 pubmed publisher
    ..Successful resolution of these issues will pave the way for the development of a powerful tool to induce the permanent sterility in cats. ..
  11. An R, Xi C, Xu J, Liu Y, Zhang S, Wang Y, et al. Intramyocardial Injection of Recombinant Adeno-Associated Viral Vector Coexpressing PR39/Adrenomedullin Enhances Angiogenesis and Reduces Apoptosis in a Rat Myocardial Infarction Model. Oxid Med Cell Longev. 2017;2017:1271670 pubmed publisher
    ..This study suggests a potential novel gene therapy-based method that could be used clinically for myocardial infarction. ..
  12. Thekke Veetil T, Tzanetakis I. Development of reliable detection assays for blueberry mosaic- and blackberry vein banding- associated viruses based on their population structures. J Virol Methods. 2017;248:191-194 pubmed publisher
    ..Given the increasing global trade of both blueberry and blackberry these tests will be valuable in avoiding virus introductions to new areas. ..
  13. Yoo R, Lee S, Lim S, Zhao F, Igori D, Baek D, et al. Complete genome analysis of a novel umbravirus-polerovirus combination isolated from Ixeridium dentatum. Arch Virol. 2017;162:3893-3897 pubmed publisher
    ..Genome properties and phylogenetic analysis suggested that IxYMaV-1 and -2 are representative isolates of new species classifiable within the genus Polerovirus and Umbravirus, respectively. ..
  14. Reichel F, Dauletbekov D, Klein R, Peters T, Ochakovski G, Seitz I, et al. AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye. Mol Ther. 2017;25:2648-2660 pubmed publisher 02610582). ..
  15. Ito M, Ohno K. Protein-anchoring therapy to target extracellular matrix proteins to their physiological destinations. Matrix Biol. 2018;68-69:628-636 pubmed publisher
    ..We propose that protein-anchoring therapy could be applied to hereditary/acquired defects in ECM and secreted proteins, as well as therapeutic overexpression of such factors. ..
  16. Rey Rico A, Cucchiarini M. Controlled release strategies for rAAV-mediated gene delivery. Acta Biomater. 2016;29:1-10 pubmed publisher
    ..Here, we give an overview of the most recent advances on the controlled release of vectors with a focus on rAAV using adapted biomaterials and discuss the key challenges for a safe translation in patients. ..
  17. Chandra R, Engeln M, Francis T, Konkalmatt P, Patel D, Lobo M. A Role for Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Nucleus Accumbens Neuron Subtypes in Cocaine Action. Biol Psychiatry. 2017;81:564-572 pubmed publisher
    ..Finally, we demonstrate a bidirectional role for PGC-1α in mediating behavioral plasticity to cocaine through D1-MSNs versus D2-MSNs. ..
  18. Arrant A, Filiano A, Unger D, Young A, Roberson E. Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia. Brain. 2017;140:1447-1465 pubmed publisher
    ..These data support the concept of progranulin-boosting therapies for frontotemporal dementia and highlight an important role for neuron-derived progranulin in maintaining normal social function. ..
  19. Lin W, Vann D, Doulias P, Wang T, Landesberg G, Li X, et al. Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. J Clin Invest. 2017;127:2407-2417 pubmed publisher
    ..This work provides a mechanistic basis for the association of SLC39A8 with whole-blood Mn, potentially linking SLC39A8 variants with other physiological traits. ..
  20. Sun Y, Liu C, Wang Z, Meng S, Burnim S, SanGiovanni J, et al. RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis. FASEB J. 2017;31:4492-4502 pubmed publisher
    ..Sun, Y., Liu, C.-H., Wang, Z., Meng, S. S., Burnim, S. B., SanGiovanni, J. P., Kamenecka, T. M., Solt, L. A., Chen, J. RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis. ..
  21. Zhao Q, Lu J, Yao J, Zhang Z, Ling C, Mei Y. Neuritin reverses deficits in murine novel object associative recognition memory caused by exposure to extremely low-frequency (50 Hz) electromagnetic fields. Sci Rep. 2015;5:11768 pubmed publisher
    ..Neuritin prevented this ELF MFs-exposure-induced effect by increasing the hippocampal spine density. ..
  22. Li L, Ma C, Awong G, Kennedy M, Gornalusse G, Keller G, et al. Silent IL2RG Gene Editing in Human Pluripotent Stem Cells. Mol Ther. 2016;24:582-91 pubmed publisher
  23. Yang J, Kou J, Lim J, Lalonde R, Fukuchi K. Intracranial delivery of interleukin-17A via adeno-associated virus fails to induce physical and learning disabilities and neuroinflammation in mice but improves glucose metabolism through AKT signaling pathway. Brain Behav Immun. 2016;53:84-95 pubmed publisher
  24. Zeng C, Wu A, Wang Y, Xu S, Tang Y, Jin X, et al. Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales. J Virol. 2016;90:6675-6685 pubmed publisher
    ..These results extend our understanding of nidovirus RNA capping and methylation beyond coronaviruses and also strengthen the evolutionary and functional links between roniviruses and coronaviruses. ..
  25. Cheng Y, Liu Y, Wang Y, Niu Q, Gao Q, Fu Q, et al. Chicken DNA virus sensor DDX41 activates IFN-β signaling pathway dependent on STING. Dev Comp Immunol. 2017;76:334-342 pubmed publisher
    ..Therefore, our results suggest that chDDX41 is involved in the dsDNA- and dsDNA virus-mediated chDDX41-chSTING-IFN-β signaling pathway in chicken cells. ..
  26. Day T, Byrne L, Flannery J, Schaffer D. Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods Mol Biol. 2018;1715:239-249 pubmed publisher
    ..This necessitates prescreening of NHPs before intravitreal delivery of AAV. In this chapter, we describe a method for screening NHP serum for preexisting NABs. ..
  27. Wasala N, Shin J, Lai Y, Yue Y, Montanaro F, Duan D. Cardiac specific expression of ∆H2-R15 mini-dystrophin normalized all ECG abnormalities and the end-diastolic volume in a 23-m-old mouse model of Duchenne dilated cardiomyopathy. Hum Gene Ther. 2018;: pubmed publisher
    ..We conclude that that ∆H2-R15 mini-dystrophin is a superior candidate gene for heart protection. This finding has important implications in the design of the mini/micro-dystrophin gene for Duchenne cardiomyopathy therapy. ..
  28. Jin Q, Qiao C, Li J, Li J, Xiao X. Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth. Mol Ther. 2018;26:1109-1117 pubmed publisher
    ..In sum, our results suggest GDF11 overexpression has an inhibitory effect on skeletal muscle growth. ..
  29. Ngounga T, Pagnier I, Reteno D, Raoult D, La Scola B, Colson P. Real-time PCR systems targeting giant viruses of amoebae and their virophages. Intervirology. 2013;56:413-23 pubmed publisher
    ..PCR systems such as those implemented here may contribute to an improved understanding of the prevalence of mimiviruses, their virophages and marseilleviruses in humans. ..
  30. Akhtar S, Khan A, Singh A, Briddon R. Identification of a disease complex involving a novel monopartite begomovirus with beta- and alphasatellites associated with okra leaf curl disease in Oman. Arch Virol. 2014;159:1199-205 pubmed publisher
    ..This is the first report of a begomovirus-satellite complex infecting okra in Oman...
  31. Shahmoradi A, Radyushkin K, Rossner M. Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci U S A. 2015;112:E3582-9 pubmed publisher
    ..Our analyses provide evidence that the control of sleep and memory consolidation may share common molecular mechanisms. ..
  32. Liu W, Zhao L, Blackman B, Parmar M, Wong M, Woo T, et al. Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice. J Neurosci. 2016;36:12425-12435 pubmed
    ..Using AAV vectors to deliver antibodies like PHF1 directly to brain may constitute a novel approach to treating various neurodegenerative disorders, such as FTD and Alzheimer's disease. ..
  33. Rezaie E, Visser N, Friedrich P, Shin A, Bishop A. Intra-luminal gene therapy in the porcine artery using a recombinant adeno-associated virus 9. Gene. 2017;618:24-27 pubmed publisher
    ..The ability to limit delivery of the gene to an isolated segment of vessel is desirable for future research applications. ..
  34. Redchuk T, Karasev M, Omelina E, Verkhusha V. Near-Infrared Light-Controlled Gene Expression and Protein Targeting in Neurons and Non-neuronal Cells. Chembiochem. 2018;19:1334-1340 pubmed publisher
    ..The small size of the QPAS1 component allowed the design of adeno-associated virus (AAV) particles, which were applied to deliver the TA system to neurons. ..
  35. Chen Y, Chang M, Davidson B. Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy. Nat Med. 2009;15:1215-8 pubmed publisher
    ..Peripheral injection of the epitope-modified AAVs expressing the enzymes lacking in LSD mice reconstituted enzyme activity throughout the brain and improved disease phenotypes in two distinct disease models. ..
  36. Greenberg B, Butler J, Felker G, Ponikowski P, Voors A, Desai A, et al. Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial. Lancet. 2016;387:1178-86 pubmed publisher
    ..Celladon Corporation. ..
  37. Kaminski R, Bella R, Yin C, Otte J, Ferrante P, Gendelman H, et al. Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study. Gene Ther. 2016;23:690-5 pubmed publisher
  38. Lee J, Kim Y, Yoon Y, Kim Y, Oh S, Jang J, et al. Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells. N Biotechnol. 2017;37:194-199 pubmed publisher
    ..This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies. ..
  39. Li Y, Yan H, Wang F, Huang S, Zhang Y, Wang Z, et al. Activation of EphA1-Epha receptor axis attenuates diabetic nephropathy in mice. Biochem Biophys Res Commun. 2017;486:693-699 pubmed publisher
    ..Mechanistically, the overexpression of EphA1 could inhibit MAPK and the Rho pathway in diabetic kidneys. ..
  40. Lhériteau E, Davidoff A, Nathwani A. Haemophilia gene therapy: Progress and challenges. Blood Rev. 2015;29:321-8 pubmed publisher
    ..This review provides a summary of the progress made to date and discusses the remaining changes. ..
  41. Spencer N. Switching off pain at the source: is this the end for opioid pain relief?. Pain Manag. 2016;6:39-47 pubmed publisher
    ..7 ion channels only in sensory neurons underlying pain perception. The major advantage is that pain may be suppressed at the source for many months, without the side effects of opiates. ..
  42. de Leeuw C, Korecki A, Berry G, Hickmott J, Lam S, Lengyell T, et al. rAAV-compatible MiniPromoters for restricted expression in the brain and eye. Mol Brain. 2016;9:52 pubmed publisher
    ..Overall, the methodology and MiniPs presented here represent important advances for basic and preclinical research, and may enable a paradigm shift in gene therapy. ..
  43. Hickmott J, Chen C, Arenillas D, Korecki A, Lam S, Molday L, et al. PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina. Mol Ther Methods Clin Dev. 2016;3:16051 pubmed publisher
    ..Combined, they capture all four cell types, making them potential tools for research, and PAX6-gene therapy for aniridia. ..
  44. Zeng X, Li P, Ning Y, Zhao Y, Peng Y, Yang N, et al. Impaired autophagic flux is associated with the severity of trauma and the role of A2AR in brain cells after traumatic brain injury. Cell Death Dis. 2018;9:252 pubmed publisher
    ..Furthermore, A2AR may be a target for alleviating the impairment in autophagic flux after TBI. ..
  45. Montelius I, Liljas L, Unge T. Sequential removal of Ca2+ from satellite tobacco necrosis virus. Crystal structure of two EDTA-treated forms. J Mol Biol. 1990;212:331-43 pubmed
    ..One possible RNA-binding site was found in the maps of both crystal types, and the same site could also be localized in the high-resolution map of native STNV. ..
  46. Kassim S, Li H, Vandenberghe L, Hinderer C, Bell P, Marchadier D, et al. Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis. PLoS ONE. 2010;5:e13424 pubmed publisher
    ..The pre-clinical data from these studies will enable for the effective translation of gene therapy into the clinic for treatment of FH. ..
  47. Srivastava A, Raj S, Kumar S, Snehi S, Kulshreshtha A, Hallan V, et al. Molecular identification of Ageratum enation virus, betasatellite and alphasatellite molecules isolated from yellow vein diseased Amaranthus cruentus in India. Virus Genes. 2013;47:584-90 pubmed publisher
    ..cruentus, Nicotiana benthamiana, and N. glutinosa plants. We report the association of AgEV, betasatellite and alphasatellite components with yellow vein disease of A. cruentus from India. ..
  48. Zhu F, Chen T, Zhang Y, Sun H, Cao H, Lu J, et al. A Novel Adeno-Associated Virus-Based Genetic Vaccine Encoding the Hepatitis C Virus NS3/4 Protein Exhibits Immunogenic Properties in Mice Superior to Those of an NS3-Protein-Based Vaccine. PLoS ONE. 2015;10:e0142349 pubmed publisher
    ..33.NS3/4 vaccine induced stronger humoral and cellular responses than did the AAV2/rh32.33.NS3 vaccine. Our results demonstrate that AAV-based vaccines exhibit considerable potential for the development of an effective anti-HCV vaccine. ..
  49. Raissadati A, Tuuminen R, Dashkevich A, Bry M, Kivela R, Anisimov A, et al. Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury. Exp Clin Transplant. 2017;15:203-212 pubmed publisher
    ..Cardiac transgenic vascular endothelial growth factor-B overexpression failed to protect heart transplants from ischemia-reperfusion injury. ..
  50. Shao W, Chen X, Samulski R, Hirsch M, Li C. Inhibition of antigen presentation during AAV gene therapy using virus peptides. Hum Mol Genet. 2018;27:601-613 pubmed publisher
  51. Luo L, Uehara H, Zhang X, Das S, Olsen T, Holt D, et al. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. elife. 2013;2:e00324 pubmed publisher
    ..DOI: ..
  52. Soderblom C, Lee D, Dawood A, Carballosa M, Jimena Santamaria A, Benavides F, et al. 3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates,. Eneuro. 2015;2: pubmed publisher
  53. Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, et al. AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A. 2015;112:E4418-27 pubmed publisher
    ..Taken together, these preclinical data suggest that AAV9-LRMIS provides a potentially well-tolerated and effective treatment strategy poised for testing in patients with chemoresistant serous ovarian cancer. ..
  54. Kurosaki F, Uchibori R, Sehara Y, Saga Y, Urabe M, Mizukami H, et al. AAV6-mediated IL-10 expression in the lung ameliorates bleomycin-induced pulmonary fibrosis in mice. Hum Gene Ther. 2018;: pubmed publisher
    ..Furthermore, IL-10 significantly improved survival in bleomycin-induced mice. Our results provide insights into the potential benefit of the anti-fibrotic effects of IL-10 as a novel therapeutic approach for IPF. ..
  55. Wu G, Kaper J, Tousignant M, Masuta C, Kuwata S, Takanami Y, et al. Tomato necrosis and the 369 nucleotide Y satellite of cucumber mosaic virus: factors affecting satellite biological expression. J Gen Virol. 1993;74 ( Pt 2):161-8 pubmed
  56. de Felipe P. Polycistronic viral vectors. Curr Gene Ther. 2002;2:355-78 pubmed
    ..The importance of the study of viral gene expression strategies and the need to transfer this knowledge to vector design is highlighted...
  57. Gilbert R, Liu A, Petrof B, Nalbantoglu J, Karpati G. Improved performance of a fully gutted adenovirus vector containing two full-length dystrophin cDNAs regulated by a strong promoter. Mol Ther. 2002;6:501-9 pubmed
    ..We have achieved abundant dystrophin expression with our new, improved HDAd. It is anticipated that high longterm transgene expression will be possible by employing weaker immunogenic transgenes...
  58. Srivastava R, Lal S. A yeast assay for high throughput screening of natural anti-viral agents. Biochem Biophys Res Commun. 2003;301:218-21 pubmed
    ..Using such a process, we have initiated a high throughput screening process for natural anti-viral agents...
  59. Venkataravanappa V, Reddy C, Swaranalatha P, Jalali S, Briddon R, Reddy M. Diversity and phylogeography of Begomovirus-associated beta satellites of Okra in India. Virol J. 2011;8:555 pubmed publisher
    ..Begomoviruses affecting okra across the Old World are associated with specific, symptom modulating satellites (beta satellites). We describe a comprehensive analysis of the diversity of beta satellites associated with okra in India...
  60. Fiallo Olivé E, Martínez Zubiaur Y, Moriones E, Navas Castillo J. A novel class of DNA satellites associated with New World begomoviruses. Virology. 2012;426:1-6 pubmed publisher
    ..These molecules, in addition to sharing some genetic features with betasatellites and ToLCV-sat, contain nucleotide stretches of begomoviral origin, presumably the remains of recombination events involved in their origin...
  61. Kaper J, Tousignant M, Geletka L. Cucumber-mosaic-virus-associated RNA-5. XII. Symptom-modulating effect is codetermined by the helper virus satellite replication support function. Res Virol. 1990;141:487-503 pubmed
  62. Feldstein P, Buzayan J, Bruening G. Two sequences participating in the autolytic processing of satellite tobacco ringspot virus complementary RNA. Gene. 1989;82:53-61 pubmed
    ..These results map the sequences involved in autolytic processing of the complementary polarity satellite RNA to two regions...
  63. Marvik O, Sharma P, Dokland T, Lindqvist B. Bacteriophage P2 and P4 assembly: alternative scaffolding proteins regulate capsid size. Virology. 1994;200:702-14 pubmed
    ..Furthermore, we demonstrate that gpN alone undergoes the normal proteolytic maturation steps, implying that gpN processing is either autocatalytic or mediated by a host enzyme...
  64. Sabbattini P, Six E, Zangrossi S, Briani F, Ghisotti D, Deho G. Immunity specificity determinants in the P4-like retronphage phi R73. Virology. 1996;216:389-96 pubmed
    ..Analysis of phage carrying a hybrid immunity system indicates that, although two target sequences are required for the establishment of lysogeny, a single site is sufficient to make a phage sensitive to the prophage immunity...
  65. Nakashima N, Kawahara N, Omura T, Noda H. Characterization of a novel satellite virus and a strain of Himetobi P virus (Dicistroviridae) from the brown planthopper, Nilaparvata lugens. J Invertebr Pathol. 2006;91:53-6 pubmed
    ..Transmission tests showed that the satellite was transmitted vertically; however, its helper virus was unknown. We named this satellite Nilaparvata lugens commensal X virus (NLCXV)...
  66. Ziebell H, Carr J. Cross-protection: a century of mystery. Adv Virus Res. 2010;76:211-64 pubmed publisher
    ..We also discuss the potential of cross-protection to contribute in future to the maintenance of crop health in the face of emerging virus diseases and related threats to agricultural production...
  67. Tahir M, Amin I, Briddon R, Mansoor S. The merging of two dynasties--identification of an African cotton leaf curl disease-associated begomovirus with cotton in Pakistan. PLoS ONE. 2011;6:e20366 pubmed publisher
  68. Elbeaino T, Digiaro M, Martelli G. Complete sequence of Fig fleck-associated virus, a novel member of the family Tymoviridae. Virus Res. 2011;161:198-202 pubmed publisher
    ..FFkaV was found in field-grown figs from six Mediterranean countries with an incidence ranging from 15% to 25%...
  69. Mandadi K, Scholthof K. Characterization of a viral synergism in the monocot Brachypodium distachyon reveals distinctly altered host molecular processes associated with disease. Plant Physiol. 2012;160:1432-52 pubmed publisher
    ..Taken together, our results identified distinctly altered immune responses in monocot antiviral defenses and provide insights into monocot viral synergism...
  70. Kaper J, Tousignant M, Steen M. Cucumber mosaic virus-associated RNA 5. XI. Comparison of 14 CARNA 5 variants relates ability to induce tomato necrosis to a conserved nucleotide sequence. Virology. 1988;163:284-92 pubmed
    ..These findings constitute a basis for experiments aimed at determining the biological significance, if any, of these ORFs...
  71. Liu J, Lin N. Satellite RNA associated with bamboo mosaic potexvirus shares similarity with satellites associated with sobemoviruses. Arch Virol. 1995;140:1511-4 pubmed
    ..The sequence similarity among satellite plant viruses which have no apparent relationship implies a common origin...
  72. Larson S, Koszelak S, Day J, Greenwood A, Dodds J, McPherson A. Three-dimensional structure of satellite tobacco mosaic virus at 2.9 A resolution. J Mol Biol. 1993;231:375-91 pubmed
    ..The nucleic acid is distributed within the virion with a high degree of order. The capsid protein is a true double helical RNA binding protein and a number of prominent interactions between protein and RNA can be clearly seen...
  73. Julien B, Calendar R. Bacteriophage PSP3 and phiR73 activator proteins: analysis of promoter specificities. J Bacteriol. 1996;178:5668-75 pubmed
    ..Thus, the differences in transcriptional activity are probably due to interactions between the activators and RNA polymerase, rather than interactions between the activators and DNA...
  74. Meulewaeter F, Van Montagu M, Cornelissen M. Features of the autonomous function of the translational enhancer domain of satellite tobacco necrosis virus. RNA. 1998;4:1347-56 pubmed
    ..On dicistronic RNAs, TED stimulates translation of both cistrons to the same extent. These data suggest that TED acts primarily by recruiting the translational machinery to the RNA...
  75. Pearson H. 'Virophage' suggests viruses are alive. Nature. 2008;454:677 pubmed publisher
  76. Christie G, Calendar R. Interactions between satellite bacteriophage P4 and its helpers. Annu Rev Genet. 1990;24:465-90 pubmed
    ..Elucidation of the mechanisms underlying these interactions promises to provide new insights into strategies for control of gene expression...
  77. Marvik O, Jacobsen E, Dokland T, Lindqvist B. Bacteriophage P2 and P4 morphogenesis: assembly precedes proteolytic processing of the capsid proteins. Virology. 1994;205:51-65 pubmed
    ..This result supports the conclusion that gpO is required for both phages and strongly suggests that the O derivative, h7 (found in mature capsids), results from proteolytic cleavage after gpN/gpO coassembly...
  78. Nee S. Mutualism, parasitism and competition in the evolution of coviruses. Philos Trans R Soc Lond B Biol Sci. 2000;355:1607-13 pubmed
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    ..The products of the sid transcription unit are needed only when a helper phage is present; thus, the satellite phage activators repress transcription until the helper is present to supply a nonrepressing activator...
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    ..Likewise, the entire STNV-C CP-encoding region could be deleted and replaced with a marker gene of a similar size without loss of transcript accumulation in plants...
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    ..5-kDa SPMV CP. This represents the first report of a D-RNA associated with a satellite virus...