moloney murine sarcoma virus

Summary

Summary: A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) isolated from a rhabdomyosarcoma by Moloney in 1966.

Top Publications

  1. Gunther C, Nye J, Bryner R, Graves B. Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus. Genes Dev. 1990;4:667-79 pubmed
    ..thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus (MSV) long terminal repeat (LTR)...
  2. Nanni P, Azzarello G, Tessarollo L, De Giovanni C, Lollini P, Nicoletti G, et al. In vitro differentiation of rhabdomyosarcomas induced by nickel or by Moloney murine sarcoma virus. Br J Cancer. 1991;63:736-42 pubmed
    ..Myogenic differentiation ability was retained at a good level by nickel-induced tumours, whereas it was strongly impaired in MSV-induced tumours...
  3. Huleihel M, Ishano V. Effect of propolis extract on malignant cell transformation by moloney murine sarcoma virus. Arch Virol. 2001;146:1517-26 pubmed
    ..aqueous extract of propolis was found to significantly inhibit NIH/3T3 cell malignant transformation by Moloney murine sarcoma virus (MuSV-124)...
  4. Achkar C, Gong Q, Frankfater A, Bajkowski A. Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts. J Biol Chem. 1990;265:13650-4 pubmed
    ..Latent forms of beta-glucuronidase were not detected. In contrast, Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts (MMSV) secreted greatly increased amounts of latent cathepsin B (17-..
  5. Birnbaum M, Shainberg A, Salzberg S. Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity. Virology. 1993;194:865-9 pubmed
    Infection of rat skeletal muscle cultures on the first or second day in vitro with Moloney murine sarcoma virus (MSV) led to the arrest of myotube formation and to inhibition of both the synthesis of the muscle-specific proteins ..
  6. Balzarini J, Schols D, Van Laethem K, De Clercq E, Hocková D, Masojidkova M, et al. Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. J Antimicrob Chemother. 2007;59:80-6 pubmed
    ..The compounds were evaluated against HIV and Moloney murine sarcoma virus (MSV) in cell culture, including a broad variety of HIV-1 clade clinical isolates and relevant mutant (..
  7. Biasi G, Facchinetti A, Panozzo M, Zanovello P, Chieco Bianchi L, Collavo D. Moloney murine leukemia virus tolerance in anti-CD4 monoclonal antibody-treated adult mice. J Immunol. 1991;147:2284-9 pubmed
    ..a short term treatment with anti-CD4 mAb developed T cell lymphomas, or sarcomas when rechallenged with Moloney murine sarcoma virus (M-MSV)...
  8. Rosato A, Bronte V, Mandruzzato S, Zambon A, Calderazzo F, Biasi G, et al. Role of adhesion molecules in the immune reaction to M-MSV-induced tumors. Int J Cancer Suppl. 1992;7:24-7 pubmed
    ..p. MEL-14 MAb treatment, by the failure of naive T lymphocytes to enter peripheral lymph nodes and subsequently by the lack of generation of tumor-specific CTLs. ..
  9. Zhi C, Migita M, Hayakawa J, Fukunaga Y. Establishment of modified retroviral vector targeting X-linked severe combined immunodeficiency. J Nippon Med Sch. 2004;71:51-6 pubmed
    ..This vector was transduced into human CD34 + progenitor cells with comparable efficiency to that of the MoMLV-based vector. The use of this newly created vector may be advantageous for gene therapy of X-SCID. ..

More Information

Publications100

  1. Pauwels R, Baba M, Balzarini J, Herdewijn P, Desmyter J, Robins M, et al. Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside. Biochem Pharmacol. 1988;37:1317-25 pubmed
    ..e. several pyrrolo[2,3-d]pyrimidine 2',3'-dideoxynucleosides, were investigated for their anti-HIV activity, but none of these derivatives proved as potent or selective as ddDAPR. ..
  2. Wood T, McGeady M, Baroudy B, Blair D, Vande Woude G. Mouse c-mos oncogene activation is prevented by upstream sequences. Proc Natl Acad Sci U S A. 1984;81:7817-21 pubmed
    ..The results presented here suggest that UMS may function to regulate c-mos proto-oncogene expression and may explain the lack of detectable c-mos transcripts in normal mouse cells. ..
  3. Goronzy J, Weyand C. Persistent suppression of virus-specific cytotoxic T cell responses after transient depletion of CD4+ T cells in vivo. J Immunol. 1989;142:4435-40 pubmed
    ..In spite of the potentials to induce low responsiveness to selected Ag by anti-CD4 conditioning, the risk to cause persistent virus-specific immunodeficiency might limit the clinical application of anti-CD4 therapy. ..
  4. Borror K, Garabedian M, DeFranco D. Glucocorticoid receptor phosphorylation in v-mos-transformed cells. Steroids. 1995;60:375-82 pubmed
    ..Thus, hyperphosphorylation of GR in v-mos-transformed cells does not appear to result from inhibition of GR dephosphorylation, but rather from stimulation of GR phosphorylation. ..
  5. Walker P, Hengge U, Udey M, Aksentijevich I, Vogel J. Viral interference during simultaneous transduction with two independent helper-free retroviral vectors. Hum Gene Ther. 1996;7:1131-8 pubmed
    ..Thus, such dual transductions will likely require in vitro selection or the use of a single retrovirus which contains both desired genes on the same genome...
  6. Balzarini J, Pannecouque C, Naesens L, Andrei G, Snoeck R, De Clercq E, et al. 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity. Nucleosides Nucleotides Nucleic Acids. 2004;23:1321-7 pubmed
    ..PMEO-DAPym derivatives proved as potent as PMEA (adefovir) and (R)-PMPA (tenofovir) in inhibiting Moloney murine sarcoma virus (MSV)-induced tumor formation in newborn NMRI mice...
  7. Steffen M, Scherdin U, Vértes I, Boecker W, Dietel M, Hölzel F. Karyotype instability and altered differentiation of rat sarcoma cells after retroviral infection. Genes Chromosomes Cancer. 1992;4:46-57 pubmed
    ..karyotypic and phenotypic stability of cultured rat fibrosarcoma cells was challenged by infection with Moloney murine sarcoma virus (MoMuSV). After transformation, the spindle-like morphology of the parental HH-16 cl...
  8. Krawczyk E, Luczak M, Kniotek M, Nowaczyk M. Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2'R,3'S)-3'-phenylisoserinate) and N-benzoyl-(2'R,3'S)-3'-phenylisoseri. J Pharm Pharmacol. 2005;57:791-7 pubmed
    ..compound, 10-deacetyl-baccatin III, influenced the growth of tumours induced in mice by infection with Moloney murine sarcoma virus. The effect of the tested compounds on T lymphocyte proliferation was evaluated by measurement of the ..
  9. Hu M, Davidson N. The inducible lac operator-repressor system is functional for control of expression of injected DNA in Xenopus oocytes. Gene. 1988;62:301-13 pubmed
    ..Mol. Cell. Biol. 5 (1985) 1945-1958]. ..
  10. Hamelin R, Honore N, Sergiescu D, Singh B, Gerfaux J, Arlinghaus R. Reversion of thermosensitive splicing defect of Moloney murine sarcoma virus ts110 by oversplicing of viral RNA. J Virol. 1990;64:1378-82 pubmed
    b>Moloney murine sarcoma virus ts110 possesses a thermosensitive splicing defect...
  11. Wen T, Kono K, Shahinian A, Kiessling R, Mak T, Klein G. CD28 is not required for rejection of unmanipulated syngeneic and autologous tumors. Eur J Immunol. 1997;27:1988-93 pubmed
    ..Secondly, the spontaneous regression of Moloney murine sarcoma virus (MMSV)-induced primary tumors in the autologous hosts occurred equally in CD28 knockouts and in ..
  12. Herzog N, Nash M, Ramagli L, Arlinghaus R. v-mos protein produced by in vitro translation has protein kinase activity. J Virol. 1990;64:3093-6 pubmed
    ..products were identical in size to p37v-mos and p43v-mos produced in protein kinase assays from Moloney murine sarcoma virus-infected cells expressing authentic p37v-mos...
  13. Beck T, Huleihel M, Gunnell M, Bonner T, Rapp U. The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. Nucleic Acids Res. 1987;15:595-609 pubmed
    ..Functionally, human A-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function. ..
  14. Jia Z, Barbier L, Stuart H, Amraei M, Pelech S, Dennis J, et al. Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation. J Biol Chem. 2005;280:30564-73 pubmed
  15. Yin P, Pathak V, Rowan A, Teufel R, Hu W. Utilization of nonhomologous minus-strand DNA transfer to generate recombinant retroviruses. J Virol. 1997;71:2487-94 pubmed
    ..A retrovirus vector, PY31, was constructed to contain the 5' and 3' cis-acting elements from Moloney murine sarcoma virus and spleen necrosis virus...
  16. Balzarini J, Herdewijn P, De Clercq E. Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo. Antiviral Res. 1989;11:161-71 pubmed
    ..It also inhibits Moloney murine sarcoma virus (MSV)-induced transformation of murine C3H/3T3 embryo fibroblasts...
  17. Chuang C, Ng S. Functional divergence of the MAP kinase pathway. ERK1 and ERK2 activate specific transcription factors. FEBS Lett. 1994;346:229-34 pubmed
    ..Therefore, the MAP kinase cascade diverges with at least one specific target for each MAP kinase isoform and provides a novel mechanism for differential regulation of this signaling pathway. ..
  18. Li W, Bowen J, Chan J. Synthesis of specific transformation-associated proteins (TAPs) in two rat cell lines is closely related to the expression of the v-mos gene product of Moloney murine sarcoma virus (Mo-MSV). Intervirology. 1987;28:50-6 pubmed
    The 6M2 cell line was established by transformation of normal rat kidney cells with the ts110 mutant of Moloney murine sarcoma virus (Mo-MSV). P85gag-mos was found to be the only known viral-transforming protein in this cell system...
  19. Jakowlew S, Kondaiah P, Flanders K, Thompson N, Dillard P, Sporn M, et al. Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells. Oncogene Res. 1988;2:135-48 pubmed
    ..The increase in TGF-beta mRNA in the transformed cells is paralleled by an increase in the level of TGF-beta protein as shown by immunoprecipitation and Western blotting procedures using specific TGF-beta antibodies...
  20. Weiland E, Grossmann A, Thiel H, Weiland F. Lactate dehydrogenase-elevating virus induces antibodies reactive with a surface antigen of aetiologically unrelated murine cell transformants. J Gen Virol. 1990;71 ( Pt 5):1233-6 pubmed
    ..We suggest that the well known tumour growth inhibition by LDV is due to LDV-induced anti-TSA antibodies. ..
  21. Baszczyňski O, Jansa P, Dracinsky M, Klepetarova B, Holy A, Votruba I, et al. Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines. Bioorg Med Chem. 2011;19:2114-24 pubmed publisher
    ..adenine and 2,6-diaminopurine were prepared and their anti-human immunodeficiency virus (HIV) and anti-Moloney murine sarcoma virus (MSV) activity was evaluated...
  22. Muller A, Pendergast A, Parmar K, Havlik M, Rosenberg N, Witte O. En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. Proc Natl Acad Sci U S A. 1993;90:3457-61 pubmed
    ..Thus, the SH2 and SH3 domains may have coordinate roles as regulatory control elements within the context of c-ABL. ..
  23. Paules R, Resnick J, Kasenally A, Ernst M, Donovan P, Vande Woude G. Characterization of activated and normal mouse Mos gene in murine 3T3 cells. Oncogene. 1992;7:2489-98 pubmed
    ..When expressed in NIH3T3 cells under the influence of the long terminal repeat regulatory element from Moloney murine sarcoma virus [NIH(pTS-1) cells], the Mos protein was present in low levels and had a half-life of about 30 min...
  24. Chan J, Scanlon M, Zhang H, Murray J. Temperature-sensitive synthesis of a metalloproteinase in ts110-MSV-M-transformed NRK cells. Biochem Biophys Res Commun. 1991;178:453-9 pubmed
    ..Accordingly, what we previously designated as TAP is apparently one form of MP, which are known to be involved in tumor cell metastasis. ..
  25. Badorrek C, Weeks K. Architecture of a gamma retroviral genomic RNA dimer. Biochemistry. 2006;45:12664-72 pubmed
    ..We developed a secondary structure model for the minimal dimerization active sequence (MiDAS) for the Moloney murine sarcoma virus in the final dimer state using selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE)...
  26. De Clercq E, Andrei G, Balzarini J, Leyssen P, Naesens L, Neyts J, et al. Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines. Nucleosides Nucleotides Nucleic Acids. 2005;24:331-41 pubmed
    ..The 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines offer substantial potential for the treatment of a broad range of retro-, hepadna-, herpes-, adeno-, and poxvirus infections. ..
  27. Włodarski K, Luczak M, Galus R, Włodarski P. Local hypertrophic/hyperplastic changes of keratinizing squamous epithelium of pinna induced by concanavalin A and other immunomodulators in mice. Folia Biol (Praha). 1999;45:217-23 pubmed
    ..It is suggested that the same growth factors, which are mediators of local chondrocyte stimulation, are also mediators of keratinocyte activation. ..
  28. Matsuo K, Oda H, Fukushima T, Matsuoka J, Hashimoto N, Tadokoro K, et al. Detection of burst-promoting activity in spleens of myeloproliferative sarcoma virus-infected mice using serum-free cultures. Acta Pathol Jpn. 1991;41:259-64 pubmed
    ..The presence of BPA- or CFU-mix-stimulating activity in the spleen after infection might be responsible for the development of panmyelosis, which is a characteristic of MPSV-induced myeloproliferative syndrome. ..
  29. Dzwonkowska B, Włodarski K. Peripheral blood and lymphatic organs in BALB/c mice during the progressive and regressive phases of Moloney sarcoma development. Folia Biol (Krakow). 2010;58:9-13 pubmed
    ..This was a long-lasting, although declining event, extending beyond tumor regression. ..
  30. Singh B, Stocking C, Walker R, Yang Y, Ostertag W, Arlinghaus R. v-mos proteins encoded by myeloproliferative sarcoma virus and its ts159 mutant. J Virol. 1992;66:1267-72 pubmed
    ..is known to have greatly reduced in vitro protein kinase activity compared with p37env-mos encoded by Moloney murine sarcoma virus. Unexpectedly, the relative activity of the MPSV v-mos protein kinase was comparable to that of p37env-..
  31. Singh B, Arlinghaus R. Vimentin phosphorylation by p37mos protein kinase in vitro and generation of a 50-kDa cleavage product in v-mos-transformed cells. Virology. 1989;173:144-56 pubmed
    ..On the basis of its mobility in two-dimensional gels, the 50-kDa form of vimentin should lack the carboxy terminus. This type of alteration could conceivably modulate the function of vimentin filaments in the transformed cell. ..
  32. Sutrave P, Kelly A, Hughes S. ski can cause selective growth of skeletal muscle in transgenic mice. Genes Dev. 1990;4:1462-72 pubmed
    ..All other tissues examined show little or no expression of the c-ski transgene. The muscles of one of the three lines were examined in more detail. Type II fast fibers undergo selective hypertrophy in affected muscles of this line. ..
  33. Huleihel M, Salman A, Erukhimovitch V, Ramesh J, Hammody Z, Mordechai S. Novel spectral method for the study of viral carcinogenesis in vitro. J Biochem Biophys Methods. 2002;50:111-21 pubmed
    ..In an attempt to identify the cellular components responsible for the observed spectral differences between normal and cancerous cells, we found significant differences between DNA of normal and cancerous cells. ..
  34. van den Wollenberg D, Hoeben R, van Ormondt H, van der Eb A. Insertion of the human cytomegalovirus enhancer into a myeloproliferative sarcoma virus long terminal repeat creates a high-expression retroviral vector. Gene. 1994;144:237-41 pubmed
    ..The vector may be particularly useful if high expression of two genes is desired. ..
  35. Hoffman R, Stoica G. A comparative endpoint study of lesions induced by MoMuSV-m1, MoMuSV-HT1, MoMuSV-124 and MoMuSV-349. Int J Exp Pathol. 1993;74:163-72 pubmed
    ..In summary, this study demonstrated that some of the different strains of MoMuSV (with the exception of MoMuSV-124 and MoMuSV-349), induced histologically distinct lesions in BALB/c mice...
  36. Nguyen T, Wang H, Zalzal S, Nanci A, Nabi I. Purification and characterization of beta-actin-rich tumor cell pseudopodia: role of glycolysis. Exp Cell Res. 2000;258:171-83 pubmed
    ..A localized glycolytic supply of energy therefore regulates the formation of beta-actin-rich pseudopodial protrusions and thereby the motility of invasive tumor cells...
  37. Caubet J, Mathieu Mahul D, Bernheim A, Larsen C, Berger R. Human proto-oncogene c-mos maps to 8q11. EMBO J. 1985;4:2245-8 pubmed
    The c-mos proto-oncogene is the cellular counterpart of the viral oncogene v-mos isolated from Moloney murine sarcoma virus. The c-mos gene locus has previously been assigned to human chromosome 8...
  38. Felzmann T, Ramsey W, Blaese R. Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retroviral or adenoviral gene transfer. Cancer Lett. 1999;135:1-10 pubmed
    ..GM-CSF secretion correlated with tumor rejection. Enhanced IFNgamma but unchanged IL-4 secretion suggested a T-helper 1-mediated anti-tumor immune response...
  39. Shu C, Guo S, Kim Y, Shelly S, Nijagal A, Ray P, et al. Visualization of a primary anti-tumor immune response by positron emission tomography. Proc Natl Acad Sci U S A. 2005;102:17412-7 pubmed
    ..The method we describe can be used to kinetically measure the induction and therapeutic modulations of cell-mediated immune responses...
  40. Salman A, Shufan E, Zeiri L, Huleihel M. Detection and identification of cancerous murine fibroblasts, transformed by murine sarcoma virus in culture, using Raman spectroscopy and advanced statistical methods. Biochim Biophys Acta. 2013;1830:2720-7 pubmed
    ..The early detection of cancer is critical for its successful therapy, which can result in complete recovery from some types of cancer...
  41. Kirschmeier P, Housey G, Johnson M, Perkins A, Weinstein I. Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences. DNA. 1988;7:219-25 pubmed
    ..The vector is flanked by the long terminal repeats (LTRs) of the Moloney murine sarcoma virus (MSV) and contains the selectable drug resistance gene neo under the regulation of the herpes simplex ..
  42. Balzarini J, Sobis H, Naesens L, Vandeputte M, De Clercq E. Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus. Int J Cancer. 1990;45:486-9 pubmed
    ..formation, and mortality associated therewith, in 6-day-old NMRI mice inoculated intracerebrally with Moloney murine sarcoma virus (MSV). Even at a dose as low as 1 mg/kg/day, PMEA effected a significant delay in tumor formation...
  43. Hermonat P. Inhibition of H-ras expression by the adeno-associated virus Rep78 transformation suppressor gene product. Cancer Res. 1991;51:3373-7 pubmed
    ..Furthermore, these and earlier data indicate that Rep78 functions as an "antioncogene" or transformation suppressor gene, inhibiting H-ras as well as several viral oncogenes...
  44. Milan G, Zambon A, Cavinato M, Zanovello P, Rosato A, Collavo D. Dissecting the immune response to moloney murine sarcoma/leukemia virus-induced tumors by means of a DNA vaccination approach. J Virol. 1999;73:2280-7 pubmed
    ..Taken together, these results indicate the existence of a hierarchy in the capacity of different structural viral proteins to induce a protective immune response against retrovirus-induced tumors...
  45. Zhang H, Scanlon M, Murray J, Chan J. Substrate preference of metalloproteinases secreted by ts-110 Moloney murine sarcoma virus-transformed normal rat kidney cells. Biochem Biophys Res Commun. 1992;189:21-6 pubmed
    ..Whether this 71-kD TAP is a new member of the rat metalloproteinase family will be investigated...
  46. Inge L, Rajasekaran S, Yoshimoto K, Mischel P, McBride W, Landaw E, et al. Evidence for a potential tumor suppressor role for the Na,K-ATPase beta1-subunit. Histol Histopathol. 2008;23:459-67 pubmed publisher
    ..These findings reveal for the first time that NaK-beta1 has a potential tumor-suppressor function in epithelial cells...
  47. Balzarini J, Kruining J, Wedgwood O, Pannecouque C, Aquaro S, Perno C, et al. Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus. FEBS Lett. 1997;410:324-8 pubmed
    ..drugs against human immunodeficiency virus type 1 (HIV-1), HIV-2, simian immunodeficiency virus (SIV), Moloney murine sarcoma virus (MSV) and human hepatitis B virus (HBV) replication regardless of the cell type in which the virus ..
  48. Rosato A, Zambon A, Macino B, Mandruzzato S, Bronte V, Milan G, et al. Anti-L-selectin monoclonal antibody treatment in mice enhances tumor growth by preventing CTL sensitization in peripheral lymph nodes draining the tumor area. Int J Cancer. 1996;65:847-51 pubmed
  49. Monteiro M, Cleveland D. Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol. 1989;108:579-93 pubmed
    ..When the NF-L coding region was linked to the strong promoter from Moloney Murine Sarcoma virus, we obtained high levels of synthesis of NF-L subunits (accumulating to as much as 9% of cell protein ..
  50. Galus R, Włodarski P, Włodarski K. Fluvastatin does not elevate periosteal osteogenesis induce by Moloney sarcoma virus (MSV) in mice. Pharmacol Rep. 2006;58:60-6 pubmed
    ..These results also point out that orthotopic bone formation at the sites of Mo-MSV inoculation in mice seems to be a useful model to examine the pleiotropic effects of statins...
  51. Hayashi Y, Tange T, Urano Y, Smadja Joffe F, Le Bousse Kerdiles M, Jasmin C. Histopathologic studies on myeloproliferative sarcoma virus (MPSV) induced leukemias and hemangiosarcoma in Jar-2 rats. Pathol Res Pract. 1988;183:314-20 pubmed
    ..MPSV can yield the tumor only in newborn rats, and target cells of MPSV are not only hematopoietic cells but also endothelial cells of the brain, spinal cord and occasionally spleen...
  52. Balzarini J, Holy A, Jindrich J, Naesens L, Snoeck R, Schols D, et al. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrob Agents Chemother. 1993;37:332-8 pubmed
    ..of PMPA were approximately 30- to 100-fold more effective against human immunodeficiency virus and Moloney murine sarcoma virus (MSV) than their enantiomeric counterparts...
  53. Zanovello P, Vallerani E, Biasi G, Landolfo S, Collavo D. Monoclonal antibody against IFN-gamma inhibits Moloney murine sarcoma virus-specific cytotoxic T lymphocyte differentiation. J Immunol. 1988;140:1341-4 pubmed
    The role of autochthonous IFN- production was evaluated in immune reactions to Moloney murine sarcoma virus (M-MSV)-induced tumors which are characterized by spontaneous regression mainly caused by virus-specific CTL activity...
  54. Dickson G, Luczak M, Włodarski K. The limitation of DEXA analysis for bone mass determination in mice. Folia Biol (Krakow). 2004;52:125-9 pubmed
    ..It is concluded that the sensitivity of the DEXA measurement is unsuitable when assessing very small bone samples, weighing merely 20-30 mg...
  55. Naesens L, Balzarini J, De Clercq E. Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo. Antiviral Res. 1991;16:53-64 pubmed
    ..investigated the effects of different PMEA and PMEDAP treatment schedules in newborn mice infected with Moloney murine sarcoma virus (MSV)...
  56. Yutzey K, Rhodes S, Konieczny S. Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4. Mol Cell Biol. 1990;10:3934-44 pubmed
  57. Morton K, Alazraki N, Datz F, Taylor A, Winge D, Lynch R. Uptake of cadmium-109, a metallothionein-binding radiometal, by tumors in mice as a function of the transformed phenotype. Invest Radiol. 1988;23:200-4 pubmed
    ..Tumors were grown in Balb/C mice from cultured Balb/3T3 cells transformed by the Moloney murine sarcoma virus (MMSV)...
  58. Yeivin A, Tang D, Taylor M. Sodium butyrate selectively induces transcription of promoters adjacent to the MoMSV viral enhancer. Gene. 1992;116:159-64 pubmed
    The long terminal repeat region of the Moloney murine sarcoma virus (MoMSV) was cloned upstream from the Chinese hamster ovary adenine phosphoribosyltransferase (APRT)-encoding gene (APRT) in order to enhance synthesis of the APRT protein...
  59. Weintraub H, Tapscott S, Davis R, Thayer M, Adam M, Lassar A, et al. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci U S A. 1989;86:5434-8 pubmed
  60. Sterner D, Murphy E. Regulation of the efficiency and thermodependence of murine sarcoma virus MuSVts110 RNA splicing by sequences in both exons. Virology. 1992;191:638-48 pubmed
  61. Huai L, Chiocca S, Gilbreth M, Ainsworth J, Bishop L, Murphy E. Moloney murine sarcoma virus MuSVts110 DNA: cloning, nucleotide sequence, and gene expression. J Virol. 1992;66:5329-37 pubmed
    We have cloned Moloney murine sarcoma virus (MuSV) MuSVts110 DNA by assembly of polymerase chain reaction (PCR)-amplified segments of integrated viral DNA from infected NRK cells (6m2 cells) and determined its complete sequence...
  62. Holy A, Gunter J, Dvorakova H, Masojidkova M, Andrei G, Snoeck R, et al. Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J Med Chem. 1999;42:2064-86 pubmed
    ..Also, the diisopropyl and diisooctyl ester of PMEDAP inhibited CMV and VZV, but esterification of the phosphonate residue did not improve the activity against either MSV or HIV...
  63. Mizuno T, Yamasaki N, Miyazaki K, Tazaki T, Koller R, Oda H, et al. Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice. Oncogene. 2008;27:3465-74 pubmed publisher
    ..These results demonstrated that overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induces acute leukemia in a transgenic model for CML...
  64. Beck Engeser G, Stocking C, Just U, Albritton L, Dexter M, Spooncer E, et al. Retroviral vectors related to the myeloproliferative sarcoma virus allow efficient expression in hematopoietic stem and precursor cell lines, but retroviral infection is reduced in more primitive cells. Hum Gene Ther. 1991;2:61-70 pubmed
    ..This inhibition of effective viral infection depends on the state of differentiation, being more pronounced in multipotent clonogenic blast cells. This block to retroviral infection affects all retroviral vectors tested...
  65. Lin C, Goldthwait D, Samols D. Induction of transcription from the long terminal repeat of Moloney murine sarcoma provirus by UV-irradiation, x-irradiation, and phorbol ester. Proc Natl Acad Sci U S A. 1990;87:36-40 pubmed
    The long terminal repeat (LTR) of Moloney murine sarcoma virus (Mo-MuSV) was used as a model system to study the stress response of mammalian cells to physical carcinogens...
  66. Dang Q, Hu W. Effects of homology length in the repeat region on minus-strand DNA transfer and retroviral replication. J Virol. 2001;75:809-20 pubmed
    ..These data demonstrate that minus-strand DNA transfer is homology driven and a minimum homology length is required for accurate and efficient minus-strand DNA transfer...
  67. Tang D, Taylor M. Transcriptional activation of the adenine phosphoribosyltransferase promoter by an upstream butyrate-induced Moloney murine sarcoma virus enhancer-promoter element. J Virol. 1990;64:2907-11 pubmed
    ..promoter was augmented instead of repressed in transfected mouse L cells when an upstream Moloney murine sarcoma virus enhancer-promoter element was induced with butyrate...
  68. Rosato A, Mandruzzato S, Bronte V, Zambon A, Macino B, Calderazzo F, et al. Role of anti-LFA-1 and anti-ICAM-1 combined MAb treatment in the rejection of tumors induced by Moloney murine sarcoma virus (M-MSV). Int J Cancer. 1995;61:355-62 pubmed
    ..Thus, our data suggest that treatment with anti-LFA-I and anti-ICAM-I MAbs combined is unable to induce T-cell tolerance in a highly immunogenic system...
  69. Gotz W, Theuring F, Schachenmayr W, Korf H. Midline brain tumors in MSV-SV 40-transgenic mice originate from the pineal organ. Acta Neuropathol. 1992;83:308-14 pubmed
    ..transgenic mice expressing the large T-antigen of the Simian virus 40 (SV 40) under the control of the Moloney murine sarcoma virus (MSV) enhancer and the SV 40 promoter develop inheritable uniform midline brain neoplasms showing ..
  70. Balzarini J, Naesens L, Herdewijn P, Rosenberg I, Holy A, Pauwels R, et al. Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proc Natl Acad Sci U S A. 1989;86:332-6 pubmed
    ..PMEA also inhibits Moloney murine sarcoma virus (Mo-MSV)-induced transformation of murine C3H embryo fibroblasts...
  71. Thiesen H, Bosze Z, Henry L, Charnay P. A DNA element responsible for the different tissue specificities of Friend and Moloney retroviral enhancers. J Virol. 1988;62:614-8 pubmed
    The transcriptional enhancers of the Moloney murine sarcoma virus (MuSV) and Moloney murine leukemia virus (MuLV) have different cell type specificities from that of the Friend MuLV...
  72. Wlodarski P, Sevignani C, Fernandes M, Calabretta B, Wlodarski K. Tumor induced by Moloney sarcoma virus causes periosteal osteogenesis engaging osteopontin, fibronectin, stromelysin-1 and tenascin. Neoplasma. 2007;54:173-9 pubmed
    ..These findings suggest that the uncommon dynamics of the Moloney sarcoma-induced osteogenesis depends on high expression of these extracellular matrix proteins...
  73. Dubey P, Su H, Adonai N, Du S, Rosato A, Braun J, et al. Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proc Natl Acad Sci U S A. 2003;100:1232-7 pubmed
    ..Splenic T cells from animals that had rejected a Moloney murine sarcoma virus/Moloney murine leukemia virus (M-MSV/M-MuLV)-induced tumor were marked with a PET reporter gene, ..
  74. Balzarini J, Pannecouque C, De Clercq E, Pavlov A, Printsevskaya S, Miroshnikova O, et al. Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics. J Med Chem. 2003;46:2755-64 pubmed
    ..hydrophobic nature displayed activity against human immunodeficiency virus type 1 (HIV-1), HIV-2, and Moloney murine sarcoma virus at a 50% inhibitory concentration in the lower micromolar (1-5 microM) concentration range while not ..
  75. Barbosa M, Vass W, Lowy D, Schiller J. In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential. J Virol. 1991;65:292-8 pubmed
    ..These same factors may, in part, account for the apparent difference in oncogenic potential between these viruses...
  76. Inoue H, Owada M, Yutsudo M, Hakura A. A rat mutant cell clone showing temperature-dependent transformed phenotypes with functional expression of the src gene product. Virology. 1989;168:57-66 pubmed
    ..from a Fischer rat cell line shows temperature-sensitivity of focus formation on infection with Moloney murine sarcoma virus (Mo-MSV) and Rous sarcoma virus (RSV)...
  77. Freire Garabal M, Núñez Iglesias M, Balboa J, Fernández Rial J, García Vallejo L, Rey Mendez M. Effects of alprazolam on the development of Moloney sarcoma virus-induced tumors in stressed mice. Cancer Detect Prev. 1996;20:160-5 pubmed
    ..Pretreatment with Ro 15-1788 (10 mg/kg s.c.), a central benzodiazepine antagonist, resulted in a suppression on both effects of alprazolam in stressed mice...
  78. de Mars M, Sterner D, Chiocca S, Biggart N, Murphy E. Regulation of RNA splicing in gag-deficient mutants of Moloney murine sarcoma virus MuSVts110. J Virol. 1990;64:1421-8 pubmed
    ..These experiments indicated that neither the MuSVts110 P58gag protein nor any other viral gene product acts in trans to regulate MuSVts110 splicing...
  79. Kopelovich L. The transformed (initiated) human cell phenotype: study of cultured skin fibroblasts from individuals predisposed to cancer. Mutat Res. 1988;199:369-85 pubmed
    ..In conjunction with clinical signs, these biomarkers can be used to determine gene expression and gene penetrance. Extension of these studies in the form of a multiparameter matrix may permit the early detection of cancer...
  80. Erkel G, Lorenzen K, Anke T, Velten R, Gimenez A, Steglich W. Kuehneromycins A and B, two new biological active compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes). Z Naturforsch C. 1995;50:1-9 pubmed
    ..The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities...
  81. Tasca S, Hoffman R, Stoica G. Detection of Moloney murine sarcoma virus in tissues and cultured cells by the polymerase chain reaction. J Virol Methods. 1993;41:255-63 pubmed
    The polymerase chain reaction was used for Moloney murine sarcoma virus (MoMuSV) detection in frozen and formalin-fixed, paraffin-embedded tissue sections and cultured cells isolated from MoMuSV-induced tumors...
  82. Naesens L, Neyts J, Balzarini J, Holy A, Rosenberg I, De Clercq E. Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice. J Med Virol. 1993;39:167-72 pubmed
    ..We now demonstrate that PMEDAP is highly efficacious when given orally to mice infected with either Moloney murine sarcoma virus (MSV), Friend leukemia virus (FLV), or murine cytomegalovirus (MCMV)...
  83. Weyand C, Goronzy J, Swarztrauber K, Fathman C. Immunosuppression by anti-CD4 treatment in vivo. Persistence of secondary antiviral immune responses. Transplantation. 1989;47:1034-8 pubmed
  84. Kobus M, Krawczyk E, Kopczacki P, Daniewski W, Łuczak M. [Influence of newly synthesized sesquiterpenes--analogs of taxol on multiplication of herpes simplex virus (HSV-1MC) and retrovirus (Mo-MSV)]. Med Dosw Mikrobiol. 2001;53:283-9 pubmed
    ..In in vivo experiments NMRI mice were infected intramuscularly with a Moloney murine sarcoma virus (Mo-MSV). Tested compounds were administered to the mice intravenously on the day of virus inoculation...
  85. Stoica G, Hoffman J, Yuen P. Moloney murine sarcoma virus 349 induces Kaposi's sarcomalike lesions in Balb/c mice. Am J Pathol. 1990;136:933-47 pubmed
    b>Moloney murine sarcoma virus (MoMuSV349) is produced by MuSV349 cells in at least eight-fold excess over the replication-competent helper virus...
  86. Yuen P, Ryan E, Devroe E, Wong P. A single Glu(62)-to-Lys(62) mutation in the Mos residues of the R7Delta447Gag-tMos protein causes the mutant virus to induce brain lesions. Oncogene. 2001;20:692-703 pubmed
    We previously reported that R7Delta447, a 2954-base-pair (bp) laboratory-generated Moloney murine sarcoma virus, induced subcutaneous tumors in about 14% of infected mice but did not induce brain lesions...
  87. Ishikawa K, Kurata N, Aoki H, Kato T, Marunouchi T. Production and characterization of a monoclonal antibody to the v-mos oncogene protein. Hybridoma. 1991;10:357-68 pubmed
    ..the protein product of the c-mos gene, the cellular homologue of the transforming gene (v-mos) of Moloney murine sarcoma virus, has not been detected in normal mouse cells or tissues...
  88. Balzarini J, Naesens L, De Clercq E. Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered. Int J Cancer. 1990;46:337-40 pubmed
    ..of human immunodeficiency virus type I (HIV-I) in MT-4 cells, transformation of C3H/3T3 cells by Moloney murine sarcoma virus (MSV), and MSV-induced tumor formation in newborn NMRI mice...
  89. Hanania E, Deisseroth A. Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model. Cancer Gene Ther. 1994;1:21-5 pubmed
    ..Furthermore, the retroviral vector system we have used could have an immediate impact in the clinical setting, where it can protect patients from the myelosuppressive side effects of Taxol in advanced stages of human epithelial cancers...
  90. Balzarini J, Naesens L, Robins M, De Clercq E. Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside. J Acquir Immune Defic Syndr. 1990;3:1140-7 pubmed
    ..They are also inhibitory to the transformation of C3H/3T3 cells by Moloney murine sarcoma virus (MSV)...
  91. Theuring F, Gotz W, Balling R, Korf H, Schulze F, Herken R, et al. Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen. Oncogene. 1990;5:225-32 pubmed
    ..Deletion of the MSV enhancer correlates with the loss of DNA elements responsible for the pineal cell specific expression of SV40 large T-antigen...