murine sarcoma viruses

Summary

Summary: A group of replication-defective viruses, in the genus GAMMARETROVIRUS, which are capable of transforming cells, but which replicate and produce tumors only in the presence of Murine leukemia viruses (LEUKEMIA VIRUS, MURINE).

Top Publications

  1. Faller D, Kourembanas S, Ginsberg D, Hannan R, Collins T, Ewenstein B, et al. Immortalization of human endothelial cells by murine sarcoma viruses, without morphologic transformation. J Cell Physiol. 1988;134:47-56 pubmed
    Amphotropic murine leukemia virus pseudotypes of murine sarcoma viruses containing the ras or mos oncogenes were constructed to permit efficient introduction of the sarcoma virus genome into early-passage human umbilical vein endothelial ..
  2. Donoghue D, Hunter T. Recombinational junctions of variants of Moloney murine sarcoma virus: generation and divergence of a mammalian transforming gene. J Virol. 1983;45:607-17 pubmed
  3. Schmidt J, Closs E, Livne E, Erfle V, Silbermann M. Biochemical characterization of a virus-induced osteosarcoma-like osseous lesion in vitro. Calcif Tissue Int. 1989;45:232-42 pubmed
  4. McCoy M, Toole J, Cunningham J, Chang E, Lowy D, Weinberg R. Characterization of a human colon/lung carcinoma oncogene. Nature. 1983;302:79-81 pubmed
    ..extending a series of recent reports which have demonstrated homologies between human oncogenes and those of Harvey and Kirsten murine sarcoma viruses. The c-Ki-ras2 oncogene of several tumour cell lines is shown to be amplified.
  5. Sobis H, Verstuyf A, Vandeputte M. Visceral yolk sac-derived tumors. Int J Dev Biol. 1993;37:155-68 pubmed
    ..Another mab, made against choriocarcinoma, was found to react specifically with the cytotrophoblast both in the normal placenta and in the tumor. No other placental cells showed a positive reaction. ..
  6. Eckert H, Stockschlader M, Just U, Hegewisch Becker S, Grez M, Uhde A, et al. High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors. Blood. 1996;88:3407-15 pubmed
    ..This observation has important consequences for a variety of ongoing and planned gene therapy trials. ..
  7. Miyaki M, Akamatsu N, Sato C, Utsunomiya J. Chemical and viral transformation of cultured skin fibroblasts from patients with familial polyposis coli. Mutat Res. 1988;199:399-414 pubmed
    ..The skin fibroblasts from many FPC patients exhibited increased susceptibility to transformation by murine sarcoma viruses. Analysis of the viral DNA and RNA after infection revealed that the increased susceptibility is ..
  8. Jansen Durr P, Meichle A, Steiner P, Pagano M, Finke K, Botz J, et al. Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A. 1993;90:3685-9 pubmed
    ..In contrast, expression of the G1 phase cyclin D1 was strongly reduced in MYC-transformed cells. In synchronized cells, repression of cyclin D1 by MYC occurred very early in the G1 phase of the cell cycle. ..
  9. Reeves L, Duffy L, Koop S, Fyffe J, Cornetta K. Detection of ecotropic replication-competent retroviruses: comparison of s(+)/l(-) and marker rescue assays. Hum Gene Ther. 2002;13:1783-90 pubmed
    ..For laboratories analyzing clinical materials, this report may prove useful in establishing detection assays for Eco-RCR. ..

More Information

Publications107 found, 100 shown here

  1. Smadja Joffe F, Moczar M, Le Bousse Kerdiles C, Delpech B, Leibovitch M, Dufour F, et al. Increased synthesis of extracellular spleen glycosaminoglycans in an experimental myeloproliferative syndrome. Leukemia. 1992;6:1011-9 pubmed
    ..This phenomenon may contribute to promote the hematopoietic stem cell proliferation characteristic of the MPSV-induced myeloproliferative disease. ..
  2. Portella G, Ferulano G, Santoro M, Grieco M, Fusco A, Vecchio G. The Kirsten murine sarcoma virus induces rat thyroid carcinomas in vivo. Oncogene. 1989;4:181-8 pubmed
  3. Hankins W, Kost T, Pragnell I. The myeloproliferative sarcoma virus causes transformation or erythroid progenitor cells in vitro. Mol Cell Biol. 1982;2:138-46 pubmed
  4. Andersen P, Devare S, Tronick S, Ellis R, Aaronson S, Scolnick E. Generation of BALB-MuSV and Ha-MuSC by type C virus transduction of homologous transforming genes from different species. Cell. 1981;26:129-34 pubmed
    ..Thus bas and ras represent retroviral transforming gene homologs that were independently transduced by mouse type C viruses from the genomes of different species. ..
  5. Jotte R, Holt J. Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma. J Cell Biol. 1996;135:457-67 pubmed
    ..While NH2-terminal myristylation is not required for FBR immortalization and transformation, it is essential in determining the degree of differentiation and tumorigenicity of malignant cells. ..
  6. Acquaviva C, Salvat C, Brockly F, Bossis G, Ferrara P, Piechaczyk M, et al. Cellular and viral Fos proteins are degraded by different proteolytic systems. Oncogene. 2001;20:942-50 pubmed
  7. Yutzey K, Rhodes S, Konieczny S. Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4. Mol Cell Biol. 1990;10:3934-44 pubmed
  8. Rother R, Thomas P. La/SSB ribonucleoprotein levels increased in transformed cells. Clin Exp Immunol. 1991;83:369-74 pubmed
    ..These data show that La/SSB is elevated in transformed cell lines compared with non-transformed counterpart cell lines and suggest that this increase is not restricted to viral transformation. ..
  9. Powell T, Spann R, Nguyenduc M, Lamon E. Induction of effective immunity to Moloney murine sarcoma virus using monoclonal anti-idiotypic antibody as immunogen. J Immunol. 1989;142:1318-24 pubmed
    ..1.3 immunization. These results indicate that anti-idiotypic mAb may be used as immunogen to induce Ag-specific antibody responses, and to cause effective immunity to a retro-virus-induced tumor. ..
  10. Curran T, MacConnell W, van Straaten F, Verma I. Structure of the FBJ murine osteosarcoma virus genome: molecular cloning of its associated helper virus and the cellular homolog of the v-fos gene from mouse and human cells. Mol Cell Biol. 1983;3:914-21 pubmed
    ..5, and 0.5 kb were separated by four regions of nonhomology of 0.76, 0.55, 0.1, and 0.1 kb from 5' to 3' with respect to the FBJ-MSV genome. The size of these sequences showed striking similarity in both c-fos(mouse) and c-fos(human). ..
  11. David S, Nissim A, Chebath J, Salzberg S. 2'-5'-oligoadenylate synthetase gene expression in normal and murine sarcoma virus-transformed NIH 3T3 cells. J Virol. 1989;63:1116-22 pubmed
    ..These results suggest that at least IFN-beta secretion is not involved in the elevated level of 2-5A synthetase gene expression in these cells. ..
  12. Shih T, Papageorge A, Stokes P, Weeks M, Scolnick E. Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature. 1980;287:686-91 pubmed
    ..These biochemical activities are unique among those associated with transforming proteins of RNA-containing or DNA-containing tumour viruses. ..
  13. Jansen M, Bardenheuer W, Sorg U, Seeber S, Flasshove M, Moritz T. Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones. Eur J Haematol. 2001;67:2-13 pubmed
    ..These data may help to optimize treatment design and retroviral constructs in future clinical studies aiming at hematoprotection by MGMT gene transfer. ..
  14. Jiang L, Maher V, McCormick J, Schindler M. Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts. J Biol Chem. 1990;265:4775-7 pubmed
    ..1 cells transformed by transfection of the v-Ki-ras or T24 H-ras oncogene was 6.1. These measurements suggest that ras transformation results in a significant perturbation of lysosomal pH. ..
  15. Eckmann L, Lohler J. [Hematopoietic stem cells (CFU-S) in retrovirus-induced murine malignant histiocytosis]. Verh Dtsch Ges Pathol. 1990;74:120-5 pubmed
    ..Multipotential stem cells show temporarily a slight increase followed by an almost total terminal ablation. The results show that MHSV has distinct effects on other hematopoietic lineages apart from its transforming properties. ..
  16. Mason R, Wilcox D, Wikstrom P, Shaw E. The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor. Biochem J. 1989;257:125-9 pubmed
    ..The secreted protein did react with the inhibitor when incubated at pH 3.0, showing that the protein can be activated, although this did not occur under our culture conditions. ..
  17. Barber J, Sassone Corsi P, Verma I. Proto-oncogene fos: factors affecting expression and covalent modification of the gene product. Ann N Y Acad Sci. 1987;511:117-30 pubmed
    ..The protein kinase C agonist, TPA, stimulates phosphorylation of the c-fos, but not the v-fos protein. ..
  18. Blair D, McClements W, Oskarsson M, Fischinger P, Vande Woude G. Biological activity of cloned Moloney sarcoma virus DNA: Terminally redundant sequences may enhance transformation efficiency. Proc Natl Acad Sci U S A. 1980;77:3504-8 pubmed
    ..1-kilobase-pair src fragment and the other containing a single copy of the terminally redundant sequence, results in a 300-fold increase in transformation efficiency...
  19. Rapp U, Goldsborough M, Mark G, Bonner T, Groffen J, Reynolds F, et al. Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A. 1983;80:4218-22 pubmed
    ..The cellular homolog, c-raf, is present in one or two copies per haploid genome in mouse and human DNA. ..
  20. Horikawa I, Yamada H, Kugoh H, Yuasa Y, Suzuki M, Oshimura M. Subchromosomal mapping of a putative transformation suppressor gene on human chromosome 1. Jpn J Cancer Res. 1995;86:444-50 pubmed
    ..Thus, chromosome and DNA analyses suggested that human 1q21 and/or 1q23-q24 carries a transformation suppressor gene(s) which controls the transformed phenotypes of DT cells. ..
  21. Zanovello P, Vallerani E, Biasi G, Landolfo S, Collavo D. Monoclonal antibody against IFN-gamma inhibits Moloney murine sarcoma virus-specific cytotoxic T lymphocyte differentiation. J Immunol. 1988;140:1341-4 pubmed
    ..On the whole, these results indicate that in M-MSV-injected mice, tumor enhancement after mAb anti-IFN- treatment is principally caused by impaired differentiation of virus-specific CTL precursors...
  22. Friel J, Hughes D, Pragnell I, Stocking C, Laker C, Nowock J, et al. The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat. J Virol. 1990;64:369-78 pubmed
    ..A contributing role of the ras point mutation in determining macrophage specificity, however, cannot be excluded...
  23. Bruyneel E, Debray H, De Mets M, Mareel M, Montreuil J. Altered glycosylation in Madin-Darby canine kidney (MDCK) cells after transformation by murine sarcoma virus. Clin Exp Metastasis. 1990;8:241-53 pubmed
    ..It is concluded that alterations in sialylation and fucosylation of the cell surface exposed glycans accompanied progression of MDCK-3 cells towards a more malignant phenotype. ..
  24. McCormick P, Shin H. Analysis of a nontumorigenic embryonal carcinoma cell line. Exp Cell Res. 1990;189:183-8 pubmed
  25. Maudsley D, Morris A. Regulation of IFN-gamma-induced host cell MHC antigen expression by Kirsten MSV and MLV. II. Effects on class II antigen expression. Immunology. 1989;67:26-31 pubmed
    ..This could be an important mechanism determining the tumourigenicity of, and immune evasion by, Ki-MSV and other viruses...
  26. Tao Cheng J, Dosemeci A, Bressler J, Brightman M, Simpson D. Characterization of synaptic vesicles and related neuronal features in nerve growth factor and ras oncogene differentiated PC12 cells. J Neurosci Res. 1995;42:323-34 pubmed
    ..Possible convergence and/or divergence on the mechanisms of NGF and ras differentiation in PC12 cells are discussed. ..
  27. Steff A, Carillo S, Pariat M, Piechaczyk M. Decreased susceptibility to calpains of v-FosFBR but not of v-FosFBJ or v-JunASV17 retroviral proteins compared with their cellular counterparts. Biochem J. 1997;323 ( Pt 3):685-92 pubmed
    ..This observation raises the interesting possibility that homologous regions in viral and cellular Fos either display slightly different conformations or are differentially accessible to interacting proteins. ..
  28. Skouv J, Ottesen S, Mark G, Autrup H. Malignant transformation of human bladder epithelial cells by DNA transfection with the v-raf oncogene. Mol Carcinog. 1989;2:59-62 pubmed
    ..In both tumorigenic transformants the level of c-myc mRNA was enhanced compared with that of the parent cell line. ..
  29. Ruther U, Garber C, Komitowski D, Muller R, Wagner E. Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature. 1987;325:412-6 pubmed
    ..Although high levels of c-fos messenger RNA were detectable in a variety of tissues, deregulated c-fos expression specifically interfered with normal bone development without inducing malignant tumours. ..
  30. Tang D, Taylor M. Transcriptional activation of the adenine phosphoribosyltransferase promoter by an upstream butyrate-induced Moloney murine sarcoma virus enhancer-promoter element. J Virol. 1990;64:2907-11 pubmed
    ..Without an adjacent Moloney murine sarcoma virus element, butyrate could not activate the aprt promoter...
  31. Nye J, Graves B. Alkylation interference identifies essential DNA contacts for sequence-specific binding of the eukaryotic transcription factor C/EBP. Proc Natl Acad Sci U S A. 1990;87:3992-6 pubmed
  32. Scherdin U, Hölzel F. [Interaction of retroviruses and oncogenes with the cellular genome. 1]. Arzneimittelforschung. 1987;37:1205-9 pubmed
  33. Torrent C, Bordet T, Darlix J. Analytical study of rat retrotransposon VL30 RNA dimerization in vitro and packaging in murine leukemia virus. J Mol Biol. 1994;240:434-44 pubmed
    ..Therefore, these findings suggest that packaging of VL30 RNA into MuLV virions requires specific interactions between RNA dimerization sequences and viral NC protein molecules. ..
  34. Julius M, Yan Q, Zheng Z, Kitajewski J. Q vectors, bicistronic retroviral vectors for gene transfer. Biotechniques. 2000;28:702-8 pubmed
    ..We demonstrate that these retroviral constructs, designated Q vectors, can be used in applications where high viral titers and high level stable or transient gene expression are desirable. ..
  35. Engels B, Noessner E, Frankenberger B, Blankenstein T, Schendel D, Uckert W. Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes. Hum Gene Ther. 2005;16:799-810 pubmed
    ..The results demonstrate that use of an optimized retroviral vector yielded a high TCR transduction efficiency and stable and high TCR expression in primary human T lymphocytes and redirected their specificity toward RCC cells. ..
  36. Principato M, Cleveland J, Rapp U, Holmes K, Pierce J, Morse H, et al. Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages. Mol Cell Biol. 1990;10:3562-8 pubmed
    ..This system should facilitate studies of developmental relationships in hematopoietic differentiation and analysis of lineage determination. ..
  37. Erukhimovitch V, Talyshinsky M, Souprun Y, Huleihel M. FTIR microscopy detection of cells infected with viruses. Methods Mol Biol. 2005;292:161-72 pubmed
    ..It seems that the change in spectral behavior is specific to the infecting virus, because cells infected with herpesviruses showed different spectral changes compared with cells infected with retroviruses. ..
  38. Goodrich D, Duesberg P. Retroviral recombination during reverse transcription. Proc Natl Acad Sci U S A. 1990;87:2052-6 pubmed
    ..The recombinants that were obtained in vitro were identical with those obtained in parallel experiments in vivo...
  39. Stoica G, Hoffman J, Yuen P. Moloney murine sarcoma virus 349 induces Kaposi's sarcomalike lesions in Balb/c mice. Am J Pathol. 1990;136:933-47 pubmed
    ..Erythrophagocytosis by the endothelial and spindlelike cells was demonstrated by light and electron microscopy. The widely disseminated lesions appear to have developed simultaneously as a consequence of viremia rather than metastasis...
  40. Dotto G, Weinberg R, Ariza A. Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells. Proc Natl Acad Sci U S A. 1988;85:6389-93 pubmed
    ..Thus, a cellular environment approximating normal tissue can suppress tumor formation triggered by a single oncogene...
  41. Higgins P. Altered expression and distribution of the cytoskeletal-associated p35 protein in NIH 3T3 cells transformed with the Harvey sarcoma virus v-ras oncogene. Int J Biochem. 1989;21:609-17 pubmed
    ..4. Proper cytoskeletal organization may be a factor in the regulation of p35 mRNA translation in situ or influence the stability of p35 independent of translational rate...
  42. Suijkerbuijk B, Niculescu Duvaz I, Gaulon C, Dijkstra H, Niculescu Duvaz D, Ménard D, et al. Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group. J Med Chem. 2010;53:2741-56 pubmed publisher
    ..Concomitant benefits are good oral bioavailability and high plasma concentrations in vivo...
  43. Skaro Milić A, Spasic P. [Ultrastructural changes in tumor cell nuclei during spontaneous regression of induced mouse sarcoma virus tumors]. Vojnosanit Pregl. 1992;49:425-31 pubmed
    ..It has been concluded that the changes of apoptosis of tumour cells occurred most frequently...
  44. de Mars M, Sterner D, Chiocca S, Biggart N, Murphy E. Regulation of RNA splicing in gag-deficient mutants of Moloney murine sarcoma virus MuSVts110. J Virol. 1990;64:1421-8 pubmed
    ..These experiments indicated that neither the MuSVts110 P58gag protein nor any other viral gene product acts in trans to regulate MuSVts110 splicing...
  45. Theuring F, Gotz W, Balling R, Korf H, Schulze F, Herken R, et al. Tumorigenesis and eye abnormalities in transgenic mice expressing MSV-SV40 large T-antigen. Oncogene. 1990;5:225-32 pubmed
    ..Deletion of the MSV enhancer correlates with the loss of DNA elements responsible for the pineal cell specific expression of SV40 large T-antigen...
  46. Wisdom R, Verma I. Revertants of v-fos-transformed rat fibroblasts: suppression of transformation is dominant. Mol Cell Biol. 1990;10:5626-33 pubmed
    ..This contrasts with previously described revertants of transformation by v-fos that contain recessive mutations...
  47. Rossi L, Barbieri O, Capurro G, Aiello C, Ruzzon T, Muratore O. Skin papillomas and other neoplasms induced by murine sarcoma viruses in mid-gestation-infected mice. Int J Cancer. 1988;42:261-6 pubmed
    ..Later infections (in 15-day-old fetuses and neonates) mainly induced mesenchymal sarcomas. No congenital malformations were detected in the embryos exposed to MSV during organogenesis, although some abortions and resorptions were seen...
  48. Stallings R, Crawford B, Black R, Chang E. Assignment of RAS proto-oncogenes in Chinese hamsters: implications for mammalian gene linkage conservation and neoplasia. Cytogenet Cell Genet. 1986;43:2-5 pubmed
  49. Van Beveren C, Galleshaw J, Jonas V, Berns A, Doolittle R, Donoghue D, et al. Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus. Nature. 1981;289:258-62 pubmed
    ..The predicted amino acid sequence of the mouse sarcoma virus transforming gene was found to share considerable homology with the proposed amino acid sequence of the avian sarcoma virus oncogene (src) product...
  50. Greenhalgh D, Welty D, Player A, Yuspa S. Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma. Proc Natl Acad Sci U S A. 1990;87:643-7 pubmed
    ..Since fos acts as a transcriptional regulator of other genes, malignant conversion may be an indirect consequence of the overexpression of the fos-encoded protein leading to a change in the expression of fos-controlled cellular genes...
  51. Radinsky R, Flickinger K, Kosir M, Zardi L, Culp L. Adhesion of Kirsten-ras+ tumor-progressing and Kirsten-ras- revertant 3T3 cells on fibronectin proteolytic fragments. Cancer Res. 1990;50:4388-400 pubmed
  52. Mitani H, Yagi T, Leiler C, Takebe H. 5-Azacytidine-induced recovery of O6-alkylguanine--DNA alkyltransferase activity in mouse Ha821 cells. Carcinogenesis. 1989;10:1879-82 pubmed
    ..These results suggest that reversible loss of O6AGTase activity in Ha821 cells is caused at least in part by inactivation of the O6AGTase gene due to methylation of cytosine in the gene...
  53. Biggart N, Murphy E. Analysis of metal-induced mutations altering the expression or structure of a retroviral gene in a mammalian cell line. Mutat Res. 1988;198:115-29 pubmed
    ..CdCl2 also induced frameshift mutations but, in one case, induced a mutation which may result from a deletion of about 300 bases within the MuSVts110 DNA...
  54. Dyall Smith D, Cory S. Transformation of bone marrow cells from E mu-myc transgenic mice by Abelson murine leukemia virus and Harvey murine sarcoma virus. Oncogene Res. 1988;2:403-9 pubmed
    ..Thus expression of a deregulated c-myc gene together with either v-Ha-ras or v-abl does not ensure fully autonomous growth of early B lymphoid cells...
  55. Wong Staal F, Dalla Favera R, Franchini G, Gelmann E, Gallo R. Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses. Science. 1981;213:226-8 pubmed
    ..The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias...
  56. Curran T, Peters G, Van Beveren C, Teich N, Verma I. FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J Virol. 1982;44:674-82 pubmed
    ..A single-size (3.4 kilobases long) class of RNA hybridizing to the viral fos probe was identified in FBJ-MSV-transformed cells...
  57. Izmailova E, Aldovini A. Functional analysis of the murine sarcoma virus RNA packaging sequence. J Virol. 2002;76:4643-8 pubmed
    ..Our results reveal the extent to which each of the segments of the packaging sequence contribute to packaging efficiency...
  58. Salman A, Ramesh J, Erukhimovitch V, Talyshinsky M, Mordechai S, Huleihel M. FTIR microspectroscopy of malignant fibroblasts transformed by mouse sarcoma virus. J Biochem Biophys Methods. 2003;55:141-53 pubmed
    ..Preliminary results suggested that the cluster analysis performed on the FTIR-MSP spectra yielded 100% accuracy in classifying both types of cells...
  59. Scadden D, Fuller B, Cunningham J. Human cells infected with retrovirus vectors acquire an endogenous murine provirus. J Virol. 1990;64:424-7 pubmed
    ..This RNA is transcribed from a defective mink cell focus-forming provirus and copackaged into virions and integrated into human target cell DNA at a frequency comparable to that of the recombinant retrovirus genome...
  60. Tagliaferri P, Katsaros D, Clair T, Neckers L, Robins R, Cho Chung Y. Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs. J Biol Chem. 1988;263:409-16 pubmed
    ..It is concluded that the observed growth inhibition and phenotypic reversion of 13-3B-4 cells is most likely mediated through the cellular effector, the RII cAMP receptor protein...
  61. Manly K, Anderson G, Stoler D. Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras. J Virol. 1988;62:3540-3 pubmed
    ..The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences...
  62. Fraser C, Sykes M, Lee R, Sachs D, LeGuern C. Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway. J Immunol. 1995;154:1587-95 pubmed
    ..Tolerance to Kb induced by this approach may therefore be restricted to T helper cell lineages...
  63. Millauer B, Shawver L, Plate K, Risau W, Ullrich A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature. 1994;367:576-9 pubmed
    ..Our results emphasize the central role of the Flk-1/VEGF system in angiogenesis in general and in the development of solid tumours in particular...
  64. Xia W, Bringmann P, McClary J, Jones P, Manzana W, Zhu Y, et al. High levels of protein expression using different mammalian CMV promoters in several cell lines. Protein Expr Purif. 2006;45:115-24 pubmed
    ..Using the CMV driven constitutive promoters in the presence of intron A, we have been able to generate >10 microg/ml of recombinant protein using transient transfections...
  65. Zarudnaya M, Kolomiets I, Potyahaylo A, Hovorun D. Dimer linkage structure in retroviruses: models that include both duplex and quadruplex domains. Ukr Biokhim Zh (1999). 2005;77:5-15 pubmed
    ..A model of dimer linkage structure in Moloney murine sarcoma virus (MuSV) is also presented. The structure includes a duplex formed by the palindromic sequences and several quadruplexes...
  66. Kamata N, Jotte R, Holt J. Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein. Mol Cell Biol. 1991;11:765-72 pubmed
    ..These findings demonstrate that protein myristylation can modulate gene regulation by a DNA-binding protein...
  67. Hamelin R, Honore N, Sergiescu D, Singh B, Gerfaux J, Arlinghaus R. Reversion of thermosensitive splicing defect of Moloney murine sarcoma virus ts110 by oversplicing of viral RNA. J Virol. 1990;64:1378-82 pubmed
    ..This change also appears to alter the mechanism regulating the efficiency of the genomic RNA-splicing reaction...
  68. Klinken S, Nicola N, Johnson G. In vitro-derived leukemic erythroid cell lines induced by a raf- and myc-containing retrovirus differentiate in response to erythropoietin. Proc Natl Acad Sci U S A. 1988;85:8506-10 pubmed
  69. Itoh K, Friel J, Kluge N, Kina T, Kondo Takaori A, Kawamata S, et al. A novel hematopoietic multilineage clone, Myl-D-7, is stromal cell-dependent and supported by an alternative mechanism(s) independent of stem cell factor/c-kit interaction. Blood. 1996;87:3218-28 pubmed
    ..Myl-D-7 can thus be used as an indicator cell for unknown factors that may provide stromal cell support...
  70. Holy A, Dvorakova H, Jindrich J, Masojidkova M, Budesinsky M, Balzarini J, et al. Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity. J Med Chem. 1996;39:4073-88 pubmed
    ..04-0.4 microgram/mL, and MSV (at 0.3-0.6 microgram/mL). PME-8-azaguanine (65) and (R)-PMP-8-azaguanine (71a) protected MT-4 and CEM cells against HIV-1- and HIV-2-induced cytopathicity at a concentration of approximately 2 micrograms/mL...
  71. Schott B, Kandel E, Roninson I. Efficient recovery and regeneration of integrated retroviruses. Nucleic Acids Res. 1997;25:2940-2 pubmed
    ..This procedure is suitable for expression cloning from retroviral libraries and should be applicable to the analysis of natural retrovirus populations...
  72. Balzarini J, De Clercq E, Kaminska B, Orzeszko A. Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues. Antivir Chem Chemother. 2003;14:139-44 pubmed
    ..They did not inhibit recombinant HIV-1 reverse transcriptase. All compounds were inactive against HIV in thymidine kinase-deficient cells, pointing to the compounds' requirement to release free AZT to afford antiviral efficacy...
  73. Shih T, Weeks M, Young H, Scholnick E. Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus. Virology. 1979;96:64-79 pubmed
    ..Therefore, it is concluded that the p21 of Ha-MuSV and Ki-MuSV are homologous proteins coded for bv homologous sequences found in the recombinant genomes of Ha-MuSV and Ki-MuSV...
  74. Germann U, Chin K, Pastan I, Gottesman M. Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene. FASEB J. 1990;4:1501-7 pubmed
    ..The replication-defective, recombinant MDR-ADA retrovirus should be useful to stably introduce the chimeric MDR-ADA gene into a variety of cell types for biological experiments in vitro and in vivo...
  75. Sipes N, Lyons R, Moses H. Isolation and characterization of Kirsten murine sarcoma virus-transformed mouse keratinocytes resistant to transforming growth factor beta. Mol Carcinog. 1990;3:12-9 pubmed
  76. Sadowski I, Pawson T. Catalytic and non-catalytic domains of the Fujinami sarcoma virus P130gag-fps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli. Oncogene. 1987;1:181-91 pubmed
    ..More N-terminal non-catalytic sequences appear to functionally interact with the catalytic domain...
  77. Klinken S, Hartley J, Fredrickson T, Rapp U, Morse H. Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci. J Virol. 1989;63:2411-4 pubmed
    ..From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait...
  78. Le Bousse Kerdiles M, Fernandez Delgado R, Smadja Joffe F, Massier E, Degiorgis V, Bertoli A, et al. Abnormal splenic megakaryopoiesis in MPSV-induced myeloproliferative disease. Leuk Res. 1987;11:781-7 pubmed
  79. Kas K, Schoenmakers E, Van de Ven W, Weber G, Nordenskjold M, Michiels L, et al. Assignment of the human FAU gene to a subregion of chromosome 11q13. Genomics. 1993;17:387-92 pubmed
    ..This fine mapping assigned FAU close to the skeletal muscle glycogen phosphorylase gene (PYGM), in a region that contains several oncogenes as well as the putative tumor suppressor genes MEN1 and ST3...
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