feline sarcoma viruses

Summary

Summary: Species of GAMMARETROVIRUS isolated from fibrosarcoma in cats. The viruses are actually recombinant feline leukemia viruses (FeLV) where part of the genome has been replaced by cellular oncogenes. It is unique to individuals and not transmitted naturally to other cats. FeSVs are replication defective and require FeLV to reproduce.

Top Publications

  1. Cullen C, Haines D, Jackson M, Grahn B. Lack of detection of feline leukemia and feline sarcoma viruses in diffuse iris melanomas of cats by immunohistochemistry and polymerase chain reaction. J Vet Diagn Invest. 2002;14:340-3 pubmed
    ..Feline leukemia virus/feline sarcoma virus was not detected in any neoplasms and therefore was unlikely to play a role in the tumorigenesis of these feline diffuse iris melanomas...
  2. Hampe A, Laprevotte I, Galibert F, Fedele L, Sherr C. Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes. Cell. 1982;30:775-85 pubmed
  3. Lyman S, Rohrschneider L. Analysis of functional domains of the v-fms-encoded protein of Susan McDonough strain feline sarcoma virus by linker insertion mutagenesis. Mol Cell Biol. 1987;7:3287-96 pubmed
    ..Mutations that were introduced within the external domain had little effect on in vitro kinase activity, whereas mutations within the cytoplasmic domain all had strong inhibitory effects on this activity...
  4. Tronick S, Popescu N, Cheah M, Swan D, Amsbaugh S, Lengel C, et al. Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci U S A. 1985;82:6595-9 pubmed
    ..1-36.2 by in situ hybridization. Taken together, our findings establish that the fgr protooncogene is a unique member of the tyrosine kinase gene family...
  5. van Groningen J, van den Ouweland A, Verbeek J, Van Der Kemp A, Bloemers H, Van de Ven W. Structural analysis of a variant clone of Snyder-Theilen feline sarcoma virus. Virus Res. 1987;8:349-61 pubmed
    ..In addition, both clones differed also from each other with respect to genetic sequences deleted from their env gene regions...
  6. Barbacid M, Beemon K, Devare S. Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proc Natl Acad Sci U S A. 1980;77:5158-62 pubmed
    ..Thus, independent transforming virus isolates from birds, mice, and cats may utilize common pathways in exerting their oncogenic potential...
  7. Maruyama K, Fukushima T, Miyauchi M, Koshikawa N, Kawamura K, Mochizuki S. V-onc mutation associated with host cell growth in retroviral tumors. Leukemia. 1995;9 Suppl 1:S89-92 pubmed
  8. Kappes B, Ziemiecki A, Muller R, Theilen G, Bauer H, Barnekow A. The TP1 isolate of feline sarcoma virus encodes a fgr-related oncogene lacking gamma actin sequences. Oncogene. 1989;4:363-72 pubmed
  9. Maruyama K, Miyauchi M, Mochizuki S, Fukushima T, Koshikawa N, Kawamura K, et al. Suppression of retroviral tumors in hosts immune to viral oncogene product. Leukemia. 1994;8 Suppl 1:S190-3 pubmed
    ..These results indicate that tumors caused by perinatal retrovirus infection may be suppressed by efficient elicitation of cell-mediated immune response against the product of oncogene of the causative virus...

More Information

Publications36

  1. Kopelovich L, Wang T. Histiocytic conversion of human adult skin fibroblasts by the Snyder-Theilen feline sarcoma virus. Eur Cytokine Netw. 1990;1:157-68 pubmed
  2. Kopelovich L. Conversion of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus (ST:FeSV(FeLV)): productive infection by Leishmania major. Immunol Lett. 1994;43:195-8 pubmed
    ..major. These results point to the utility of ST:FeSV-induced TM in studies that concern the role of human macrophages in T-cell differentiation during the course of infection by Leishmania...
  3. Ellis J, Jackson M, Bartsch R, McGill L, Martin K, Trask B, et al. Use of immunohistochemistry and polymerase chain reaction for detection of oncornaviruses in formalin-fixed, paraffin-embedded fibrosarcomas from cats. J Am Vet Med Assoc. 1996;209:767-71 pubmed
    ..To determine whether there was intralesional infection or expression of FeLV or feline sarcoma virus in suspected vaccine-associated fibrosarcomas in cats...
  4. Miyauchi M, Koshikawa N, Kowamura K, Fukushima T, Mochizuki S, Awaya A, et al. Augmentation with serum thymic factor of suppressive effects on retroviral tumor development in hosts immune to v-onc product. Leukemia. 1997;11 Suppl 3:213-5 pubmed
    ..All sera of animals that developed sarcomas were positive to P85 in Western blot analysis. These results showed that FTS augmented suppressive effects on sarcoma development in hosts immune to the viral oncogene product...
  5. Franchini G, Gelmann E, Dalla Favera R, Gallo R, Wong Staal F. Human gene (c-fes) related to the onc sequences of Snyder-Theilen feline sarcoma virus. Mol Cell Biol. 1982;2:1014-9 pubmed
    ..The human c-fes locus spans a region of 3.4 kilobases and contains 1.4 kilobases of DNA homologous to the viral onc sequence interspersed with three intervening sequences...
  6. Wesseling B, Kopelovich L. Differentiation of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus (ST:FeSV): growth modulation of human tumor cell lines in agar. Anticancer Res. 1997;17:2599-602 pubmed
    ..The ST:FeSV-induced macrophages demonstrate macrophage-mediated cytotoxicity (MTC) and antibody-dependent cellular cytotoxicity (ADCC), including growth modulation of tumor cells in agar (3,4,6)...
  7. Baker S, Cosenza S, Reddy E. The role of v-Fgr myristoylation and the Gag domain in membrane binding and cellular transformation. Virology. 1998;249:1-11 pubmed
  8. Kopelovich L. Conversion of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus (ST:FeSV) is associated with the de-novo expression of IL-1 alpha, IL-1 beta, IFN-alpha, TNF-alpha, GM-CSF, and CD4. Eur Cytokine Netw. 1991;2:99-106 pubmed
    ..These findings bear on the origin (heterogeneity) of TM, the nature of TM-induced cytokines, and the potential role of ST:FeSV-recruited TM during immune reactions in vivo...
  9. Tamura T, Hennig D, Grell M, Niemann H, Boschek B. Isolation of a transformation-defective mutant of the McDonough strain of feline sarcoma virus exhibiting tyrosine kinase activity in vitro but not in vivo. J Virol. 1988;62:2150-7 pubmed
    ..At low ATP concentrations (less than 5 microM) this in vitro tyrosine kinase activity was significantly reduced compared with that of the wild-type counterpart...
  10. Guilhot S, Hampe A, d Auriol L, Galibert F. Nucleotide sequence analysis of the LTRs and env genes of SM-FeSV and GA-FeSV. Virology. 1987;161:252-8 pubmed
    ..Comparison of these two FeSV sequences with the env sequences of each antigenic subgroup of FeLV (A, B, C) reveals that these two viruses can be assigned to the A/C subgroups...
  11. Nichols E, Manger R, Hakomori S, Rohrschneider L. Transformation by the oncogene v-fms: the effects of castanospermine on transformation-related parameters. Exp Cell Res. 1987;173:486-95 pubmed
    ..These results further characterize the reversion caused by castanospermine and indicate that cell surface expression coordinately controls anchorage independent growth, cell morphology, contact inhibition of growth, and hexose uptake...
  12. Heard J, Roussel M, Rettenmier C, Sherr C. Multilineage hematopoietic disorders induced by transplantation of bone marrow cells expressing the v-fms oncogene. Cell. 1987;51:663-73 pubmed
    ..Although expression of the c-fms product (CSF-1 receptor) is normally restricted to cells of the mononuclear phagocyte series, the v-fms-coded glycoprotein can contribute to proliferative abnormalities of multiple hematopoietic lineages...
  13. Trouliaris S, Hadwiger Fangmeier A, Heimann M, Tamura T. Influence of tyrosine residues Y705 and Y807 on the transforming potency of the v-fms oncogene product of feline sarcoma virus. Arch Virol. 1995;140:179-86 pubmed
    ..Four phosphoproteins of 190, 120, 55 and 50 kDa were detected in cells expressing the wild-type but were absent in cells expressing the mutant Y807F-v-fms gene...
  14. Trouliaris S, Smola U, Chang J, Parsons S, Niemann H, Tamura T. Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP. J Virol. 1995;69:6010-20 pubmed
  15. Besmer P, Murphy J, George P, Qiu F, Bergold P, Lederman L, et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature. 1986;320:415-21 pubmed
    ..The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus...
  16. Majumder S, Ray P, Besmer P. Tyrosine protein kinase activity of the HZ4-feline sarcoma virus P80gag-kit-transforming protein. Oncogene Res. 1990;5:329-35 pubmed
    ..In addition, potential in vivo protein substrates for tyrosine-specific phosphorylation mediated by the P80gag-kit kinase were identified in HZ4-FeSV-transformed cells...
  17. Riedel H. Epidermal growth factor (EGF) modulation of feline sarcoma virus fms tyrosine kinase activity, internalization, degradation, and transforming potential in an EGF receptor/v-fms chimera. J Virol. 1994;68:411-24 pubmed
    ..Despite its ligand-inducible kinase activity, EFR was partly EGF independent in mediating mitogenesis and cell transformation, while ESR appeared biologically inactive...
  18. Kopelovich L. Conversion of human fibroblasts to tissue macrophages by the Snyder-Theilen sarcoma virus (ST:FeSV): tumouricidal effects on K-562 and Daudi tumour cell lines in monolayers and in agar suspensions. Eur Cytokine Netw. 1993;4:263-8 pubmed
    ..The results indicate that ST:FeSV-induced TM are potent oncocytotoxic agents of K-562 tumour cells, but are considerably less effective against the Daudi tumour cells...
  19. Coussens L, Van Beveren C, Smith D, Chen E, Mitchell R, Isacke C, et al. Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus. Nature. 1986;320:277-80 pubmed
    ..Comparison of the feline v-fms and human c-fms sequences reveals that the proteins share extensive homology but have different carboxyl termini...
  20. Conway J, Pink H, Bergquist M, Han B, Depee S, Tadepalli S, et al. Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J Pharmacol Exp Ther. 2008;326:41-50 pubmed publisher
    ..In conclusion, GW2580 was effective in preserving joint integrity in the adjuvant arthritis model while showing minimal effects in normal rats...
  21. Kopelovich L. Conversion of human fibroblasts to tissue macrophages by the Snyder-Theilen feline sarcoma virus (ST:FeSV): tumoricidal potential in monolayers and in agar suspensions. Eur Cytokine Netw. 1992;3:63-9 pubmed
    ..The results indicate that ST:FeSV-induced macrophages are potent oncocytolytic agents of LS-180 tumor cells in the absence and in the presence of direct contact between effector and target cells...
  22. Tamura T, Hadwiger Fangmeier A, Boschek B, Niemann H. Transformation of chicken fibroblasts by the v-fms oncogene. Virology. 1990;178:401-9 pubmed
    ..In contrast, CSF-1 had none of the above effects on cells that expressed the SC2 v-fms deletion mutant...
  23. Miyoshi J, Miyoshi Y, Sasai H, Sakai N, Katsumata T, Kakunaga T. Differential requirements of gag and gamma-actin domains for transforming potential of Gardner-Rasheed feline sarcoma virus. J Virol. 1989;63:1174-80 pubmed
  24. Weyrauch G, Barnekow A. Characterization of the transforming domain of a feline sarcoma virus encoding a fgr-related tyrosine kinase. Arch Virol. 1994;134:141-55 pubmed
    ..This suggests that the gag portion of the fusion protein from TP1-FeSV is not necessary for the transformation of fibroblasts...
  25. Sugita K, Gutkind J, Katamine S, Kawakami T, Robbins K. The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities. J Virol. 1989;63:1715-20 pubmed
    ..Our findings demonstrate that the actin domain inhibits focus formation and impairs protein-tyrosine kinase activity...
  26. Shore S, La Cava M, Yendapalli S, Reddy E. Structural alterations in the carboxyl-terminal domain of the BCRABL gene product activate its fibroblastic transforming potential. J Biol Chem. 1994;269:5413-9 pubmed
  27. Borzillo G, Sherr C. Early pre-B-cell transformation induced by the v-fms oncogene in long-term mouse bone marrow cultures. Mol Cell Biol. 1989;9:3973-81 pubmed
    ..The ability of v-fms to induce transformation of early pre-B cells in vitro underscores the capacity of oncogenic mutants of the colony-stimulating factor-1 receptor to function outside the mononuclear phagocyte lineage...