allolevivirus

Summary

Summary: A bacteriophage genus of the family LEVIVIRIDAE, whose viruses contain the longer version of the genome and have no separate cell lysis gene.

Top Publications

  1. Gatto D, Ruedl C, Odermatt B, Bachmann M. Rapid response of marginal zone B cells to viral particles. J Immunol. 2004;173:4308-16 pubmed
  2. Maurer P, Jennings G, Willers J, Rohner F, Lindman Y, Roubicek K, et al. A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity. Eur J Immunol. 2005;35:2031-40 pubmed
    ..These data suggest that antibodies induced by NicQb may prevent relapses by sequestering nicotine in the blood of immunized smokers...
  3. Tsukada K, Okazaki M, Kita H, Inokuchi Y, Urabe I, Yomo T. Quantitative analysis of the bacteriophage Qbeta infection cycle. Biochim Biophys Acta. 2009;1790:65-70 pubmed publisher
    ..An average of 90 infectious phage particles per infected cell was released during a single infection cycle up to 105 min...
  4. Schuppli D, Barrera I, Weber H. Identification of recognition elements on bacteriophage Q beta minus strand RNA that are essential for template activity with Q beta replicase. J Mol Biol. 1994;243:811-5 pubmed
    ..They confirm the absence of any role of S1 protein in the interaction of replicase with minus strand RNA and further emphasize the profound difference in the interactions of replicase with the plus and minus strand...
  5. García Villada L, Drake J. The three faces of riboviral spontaneous mutation: spectrum, mode of genome replication, and mutation rate. PLoS Genet. 2012;8:e1002832 pubmed publisher
    ..These results are contrasted with those previously reported for other riboviruses to depict the current state of the art in riboviral mutagenesis...
  6. Bernhardt T, Wang I, Struck D, Young R. A protein antibiotic in the phage Qbeta virion: diversity in lysis targets. Science. 2001;292:2326-9 pubmed
    ..Thus, the two small phages characterized for their lysis strategy, Qbeta and the small DNA phage phiX174, effect host lysis by targeting different enzymes in the multistep, universally conserved pathway of cell wall biosynthesis...
  7. Takeshita D, Tomita K. Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts. Proc Natl Acad Sci U S A. 2010;107:15733-8 pubmed publisher
  8. Beekwilder J, Nieuwenhuizen R, Poot R, van Duin J. Secondary structure model for the first three domains of Q beta RNA. Control of A-protein synthesis. J Mol Biol. 1996;256:8-19 pubmed
    ..This long-distance interaction, which was recently shown to be required for minus-strand replication, is strongly supported by our comparative data...
  9. Kundig T, Senti G, Schnetzler G, Wolf C, Prinz Vavricka B, Fulurija A, et al. Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults. J Allergy Clin Immunol. 2006;117:1470-6 pubmed
    ..In this study we covalently coupled a synthetic 16-amino-acid sequence of the allergen Der p 1 to a virus-like particle derived from the bacteriophage Qbeta (Qbeta-Der p 1)...
  10. Schuppli D, Georgijevic J, Weber H. Synergism of mutations in bacteriophage Qbeta RNA affecting host factor dependence of Qbeta replicase. J Mol Biol. 2000;295:149-54 pubmed
    ..It appears to contribute little to the Hfq independence but may enhance RNA stability by re-establishing the possibility of forming a long-range base-pairing interaction involving the immediate 3'-terminal sequence...

Detail Information

Publications86

  1. Gatto D, Ruedl C, Odermatt B, Bachmann M. Rapid response of marginal zone B cells to viral particles. J Immunol. 2004;173:4308-16 pubmed
  2. Maurer P, Jennings G, Willers J, Rohner F, Lindman Y, Roubicek K, et al. A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity. Eur J Immunol. 2005;35:2031-40 pubmed
    ..These data suggest that antibodies induced by NicQb may prevent relapses by sequestering nicotine in the blood of immunized smokers...
  3. Tsukada K, Okazaki M, Kita H, Inokuchi Y, Urabe I, Yomo T. Quantitative analysis of the bacteriophage Qbeta infection cycle. Biochim Biophys Acta. 2009;1790:65-70 pubmed publisher
    ..An average of 90 infectious phage particles per infected cell was released during a single infection cycle up to 105 min...
  4. Schuppli D, Barrera I, Weber H. Identification of recognition elements on bacteriophage Q beta minus strand RNA that are essential for template activity with Q beta replicase. J Mol Biol. 1994;243:811-5 pubmed
    ..They confirm the absence of any role of S1 protein in the interaction of replicase with minus strand RNA and further emphasize the profound difference in the interactions of replicase with the plus and minus strand...
  5. García Villada L, Drake J. The three faces of riboviral spontaneous mutation: spectrum, mode of genome replication, and mutation rate. PLoS Genet. 2012;8:e1002832 pubmed publisher
    ..These results are contrasted with those previously reported for other riboviruses to depict the current state of the art in riboviral mutagenesis...
  6. Bernhardt T, Wang I, Struck D, Young R. A protein antibiotic in the phage Qbeta virion: diversity in lysis targets. Science. 2001;292:2326-9 pubmed
    ..Thus, the two small phages characterized for their lysis strategy, Qbeta and the small DNA phage phiX174, effect host lysis by targeting different enzymes in the multistep, universally conserved pathway of cell wall biosynthesis...
  7. Takeshita D, Tomita K. Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts. Proc Natl Acad Sci U S A. 2010;107:15733-8 pubmed publisher
  8. Beekwilder J, Nieuwenhuizen R, Poot R, van Duin J. Secondary structure model for the first three domains of Q beta RNA. Control of A-protein synthesis. J Mol Biol. 1996;256:8-19 pubmed
    ..This long-distance interaction, which was recently shown to be required for minus-strand replication, is strongly supported by our comparative data...
  9. Kundig T, Senti G, Schnetzler G, Wolf C, Prinz Vavricka B, Fulurija A, et al. Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults. J Allergy Clin Immunol. 2006;117:1470-6 pubmed
    ..In this study we covalently coupled a synthetic 16-amino-acid sequence of the allergen Der p 1 to a virus-like particle derived from the bacteriophage Qbeta (Qbeta-Der p 1)...
  10. Schuppli D, Georgijevic J, Weber H. Synergism of mutations in bacteriophage Qbeta RNA affecting host factor dependence of Qbeta replicase. J Mol Biol. 2000;295:149-54 pubmed
    ..It appears to contribute little to the Hfq independence but may enhance RNA stability by re-establishing the possibility of forming a long-range base-pairing interaction involving the immediate 3'-terminal sequence...
  11. Woody M, Cliver D. Replication of coliphage Q beta as affected by host cell number, nutrition, competition from insusceptible cells and non-FRNA coliphages. J Appl Microbiol. 1997;82:431-40 pubmed
    ..Competition from non-FRNA coliphages and insusceptible cells tended to reduce Q beta replication, as predicted, but phage yields unexpectedly increased significantly when Enterococcus faecalis was added to cultures...
  12. Golmohammadi R, Fridborg K, Bundule M, Valegård K, Liljas L. The crystal structure of bacteriophage Q beta at 3.5 A resolution. Structure. 1996;4:543-54 pubmed
    ..We have determined the crystal structure of phage Q beta with the aim of clarifying which factors are the most important for particle assembly and RNA interaction in the small phages...
  13. Cielens I, Ose V, Petrovskis I, Strelnikova A, Renhofa R, Kozlovska T, et al. Mutilation of RNA phage Qbeta virus-like particles: from icosahedrons to rods. FEBS Lett. 2000;482:261-4 pubmed
    ..It led to production in Escherichia coli cells of aberrant rod-like Qbeta VLPs, along with normal icosahedral capsids. The length of the rod-like particles exceeded 4-30 times the diameter of icosahedral Qbeta VLPs...
  14. Priano C, Arora R, Butke J, Mills D. A complete plasmid-based complementation system for RNA coliphage Q beta: three proteins of bacteriophages Q beta (group III) and SP (group IV) can be interchanged. J Mol Biol. 1995;249:283-97 pubmed
  15. Beekwilder M, Nieuwenhuizen R, van Duin J. Secondary structure model for the last two domains of single-stranded RNA phage Q beta. J Mol Biol. 1995;247:903-17 pubmed
    ..Close to the 3' end we find an additional conserved helix that meets the described consensus criteria for coat-protein binding...
  16. Kidmose R, Vasiliev N, Chetverin A, Andersen G, Knudsen C. Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins. Proc Natl Acad Sci U S A. 2010;107:10884-9 pubmed publisher
    ..The evolution of resistance by the host appears to be impaired because of the interactions of the beta-subunit with parts of EF-Tu essential in recognition of aminoacyl-tRNA...
  17. Kozlovska T, Cielens I, Dreilinņa D, Dislers A, Baumanis V, Ose V, et al. Recombinant RNA phage Q beta capsid particles synthesized and self-assembled in Escherichia coli. Gene. 1993;137:133-7 pubmed
  18. García Villada L, Drake J. Experimental selection reveals a trade-off between fecundity and lifespan in the coliphage Qß. Open Biol. 2013;3:130043 pubmed publisher
    ..Finally, genomic sequencing of the evolved populations pinpointed sequences likely to be involved in the evolution of Qß fecundity. ..
  19. Moody M, Burg J, DiFrancesco R, Lovern D, Stanick W, Lin Goerke J, et al. Evolution of host cell RNA into efficient template RNA by Q beta replicase: the origin of RNA in untemplated reactions. Biochemistry. 1994;33:13836-47 pubmed
    ..Sequence analysis of one of these RNAs shows that it arose by the evolution of Escherichia coli tRNA into a replicatable template and not by de novo synthesis from nucleoside triphosphates in the reaction. ..
  20. Röhn T, Ralvenius W, Paul J, Borter P, Hernandez M, Witschi R, et al. A virus-like particle-based anti-nerve growth factor vaccine reduces inflammatory hyperalgesia: potential long-term therapy for chronic pain. J Immunol. 2011;186:1769-80 pubmed publisher
    ..Thus, autovaccination targeting NGF using a VLP-based approach may represent a novel modality for the treatment of chronic pain. ..
  21. Chetverin A, Chetverina H. Molecular colony technique: a new tool for biomedical research and clinical practice. Prog Nucleic Acid Res Mol Biol. 2008;82:219-55 pubmed publisher
  22. Kazama F. Inactivation of coliphage Q beta by potassium ferrate. FEMS Microbiol Lett. 1994;118:345-9 pubmed
  23. Lau J, Baksh M, Fiedler J, Brown S, Kussrow A, Bornhop D, et al. Evolution and protein packaging of small-molecule RNA aptamers. ACS Nano. 2011;5:7722-9 pubmed publisher
    ..The system therefore comprises a general approach to the production and sequestration of functional RNA molecules, characterized by a convenient label-free analytical technique. ..
  24. Beerli R, Bauer M, Buser R, Gwerder M, Muntwiler S, Maurer P, et al. Isolation of human monoclonal antibodies by mammalian cell display. Proc Natl Acad Sci U S A. 2008;105:14336-41 pubmed publisher
    ..The human nicotine-specific mAbs were validated preclinically in a mouse model. Thus, the technology presented here allows for rapid isolation of high-affinity, fully human antibodies with therapeutic potential from human volunteers. ..
  25. Sonnleitner E, Napetschnig J, Afonyushkin T, Ecker K, Vecerek B, Moll I, et al. Functional effects of variants of the RNA chaperone Hfq. Biochem Biophys Res Commun. 2004;323:1017-23 pubmed
    ..These functional studies provided insights into the interaction of Hfq with RNA and suggested a role for the C-terminus of Hfq in DsrA stability. ..
  26. Urabe H, Ichihashi N, Matsuura T, Hosoda K, Kazuta Y, Kita H, et al. Compartmentalization in a water-in-oil emulsion repressed the spontaneous amplification of RNA by Q beta replicase. Biochemistry. 2010;49:1809-13 pubmed publisher
    ..This result indicates that the replication rate in vivo is largely explained by the presence of Hfq. This easy method paves the way for the study of genomic RNA replication without special care for the undesired RQ RNA amplification. ..
  27. Ugarov V, Demidenko A, Chetverin A. Qbeta replicase discriminates between legitimate and illegitimate templates by having different mechanisms of initiation. J Biol Chem. 2003;278:44139-46 pubmed
    ..Triggering the GTP-dependent conformational transition at the initiation step could serve as a discriminative feature of legitimate templates providing for the high template specificity of Qbeta replicase. ..
  28. Van Rompay K, Hunter Z, Jayashankar K, Peabody J, Montefiori D, LaBranche C, et al. A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251. J Virol. 2014;88:2011-24 pubmed publisher
    ..In conclusion, vaccination against CCR5 was associated with dramatic suppression of virus replication in a subset (25%) of macaques. These data support further research of vaccination against CCR5 to combat HIV infection. ..
  29. Yin Z, Dulaney S, McKay C, Baniel C, Kaczanowska K, Ramadan S, et al. Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies. Chembiochem. 2016;17:174-80 pubmed publisher
    ..Thus, bacteriophage Qβ is a suitable platform to boost antibody responses towards GM2, a representative member of an important class of TACA: the ganglioside. ..
  30. Schmitz N, Dietmeier K, Bauer M, Maudrich M, Utzinger S, Muntwiler S, et al. Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy. J Exp Med. 2009;206:1941-55 pubmed publisher
    ..Moreover, Qbeta-Fel d1 did not induce degranulation of basophils derived from human volunteers with cat allergies. These data suggest that vaccination with Qbeta-Fel d1 may be a safe and effective treatment for cat allergy. ..
  31. Hirao I, Spingola M, Peabody D, Ellington A. The limits of specificity: an experimental analysis with RNA aptamers to MS2 coat protein variants. Mol Divers. 1998;4:75-89 pubmed
    ..Aptamer pharmaceuticals may therefore better resist the evolution of resistance. ..
  32. Lindemann B, Klug C, Schwienhorst A. Evolution of bacteriophage in continuous culture: a model system to test antiviral gene therapies for the emergence of phage escape mutants. J Virol. 2002;76:5784-92 pubmed
    ..In addition, the strategy proved to be a valuable tool for observing virus-specific molecular targets under the impact of antiviral drugs. ..
  33. Schneider J, Tabatabaie T, Maidt L, Smith R, Nguyen X, Pye Q, et al. Potential mechanisms of photodynamic inactivation of virus by methylene blue. I. RNA-protein crosslinks and other oxidative lesions in Q beta bacteriophage. Photochem Photobiol. 1998;67:350-7 pubmed
    ..Due to its close correlation with Q beta inactivation and its expected lethality, RNA-protein crosslink formation may be important as an inactivating lesion in bacteriophage Q beta following MB + L exposure. ..
  34. Udit A, Everett C, Gale A, Reiber Kyle J, Ozkan M, Finn M. Heparin antagonism by polyvalent display of cationic motifs on virus-like particles. Chembiochem. 2009;10:503-10 pubmed publisher
  35. Sunada K, Minoshima M, Hashimoto K. Highly efficient antiviral and antibacterial activities of solid-state cuprous compounds. J Hazard Mater. 2012;235-236:265-70 pubmed publisher
    ..Furthermore, we found that Cu(2)O adsorbed and denatured more proteins than CuO, which suggests the difference of the inhibitory activity between Cu(2)O and CuO...
  36. Gmyl A, Agol V. [Variable mechanisms of RNA-recombination]. Mol Biol (Mosk). 2005;39:618-32 pubmed
    ..It is conceivable that RNA-recombination has contributed, and perhaps is still contributing, to the evolution of DNA genomes...
  37. Ruokoranta T, Grahn A, Ravantti J, Poranen M, Bamford D. Complete genome sequence of the broad host range single-stranded RNA phage PRR1 places it in the Levivirus genus with characteristics shared with Alloleviviruses. J Virol. 2006;80:9326-30 pubmed publisher
    ..A fourth protein has a lysis function. Comparison of PRR1 with other members of the Leviviridae family places PRR1 in the genus Levivirus with some characteristics more similar to those of members of the genus Allolevivirus.
  38. Jegerlehner A, Wiesel M, Dietmeier K, Zabel F, Gatto D, Saudan P, et al. Carrier induced epitopic suppression of antibody responses induced by virus-like particles is a dynamic phenomenon caused by carrier-specific antibodies. Vaccine. 2010;28:5503-12 pubmed publisher
  39. Avota E, Berzins V, Grens E, Vishnevsky Y, Luce R, Biebricher C. The natural 6 S RNA found in Q beta-infected cells is derived from host and phage RNA. J Mol Biol. 1998;276:7-17 pubmed
    ..RNA generated in vitro in template-free synthesis is therefore not derived from RNA species found in vivo, and replicable RNA found in vitro is generated by a mechanism fundamentally different from the one operating in vivo...
  40. Spohn G, Keller I, Beck M, Grest P, Jennings G, Bachmann M. Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis. Eur J Immunol. 2008;38:877-87 pubmed publisher
  41. Fiedler J, Higginson C, Hovlid M, Kislukhin A, Castillejos A, Manzenrieder F, et al. Engineered mutations change the structure and stability of a virus-like particle. Biomacromolecules. 2012;13:2339-48 pubmed publisher
    ..Interdimer interactions were found to be less important for VLP assembly than intradimer interactions. Finally, a single point mutation in the CP resulted in a population of smaller VLPs in three distinct structural forms...
  42. Ugarov V, Morozov IYu -, Jung G, Chetverin A, Spirin A. Expression and stability of recombinant RQ-mRNAs in cell-free translation systems. FEBS Lett. 1994;341:131-4 pubmed
    ..The enhancement is due to protection of the recombinant mRNAs against endogenous ribonucleases and to an increased initial rate of translation in the case of the RQ-CAT mRNA...
  43. Basnak G, Morton V, Rolfsson O, Stonehouse N, Ashcroft A, Stockley P. Viral genomic single-stranded RNA directs the pathway toward a T=3 capsid. J Mol Biol. 2010;395:924-36 pubmed publisher
  44. Storni T, Ruedl C, Schwarz K, Schwendener R, Renner W, Bachmann M. Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. J Immunol. 2004;172:1777-85 pubmed
    ..Thus, packaging CpGs into VLPs improves both their immunogenicity and pharmacodynamics...
  45. Usui K, Ichihashi N, Kazuta Y, Matsuura T, Yomo T. Effects of ribosomes on the kinetics of Q? replication. FEBS Lett. 2014;588:117-23 pubmed publisher
    ..This expanded model and the knowledge obtained in this study provide useful frameworks to understand the precise replication mechanism of Q? replicase with ribosomes and to design amplifiable RNA genomes in translation-coupling systems. ..
  46. Matsushita T, Shirasaki N, Matsui Y, Ohno K. Virus inactivation during coagulation with aluminum coagulants. Chemosphere. 2011;85:571-6 pubmed publisher
    ..We subsequently revealed that the viruses lost their infectivity after being mixed with hydrolyzing aluminum species during the coagulation process...
  47. Bollback J, Huelsenbeck J. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (family Leviviridae). J Mol Evol. 2001;52:117-28 pubmed
    ..the coliphage species are a monophyletic group consisting of two clades representing the genera Levivirus and Allolevivirus. The Pseudomonas species PP7 diverged from its common ancestor with the coliphage prior to the ancient split ..
  48. Biebricher C. Quantitative analysis of mutation and selection in self-replicating RNA. Adv Space Res. 1992;12:191-7 pubmed
    ..In a first step, nucleoside triphosphates are condensed randomly; self-replicating templates produced by chance are amplified and optimized...
  49. Gatto D, Pfister T, Jegerlehner A, Martin S, Kopf M, Bachmann M. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J Exp Med. 2005;201:993-1005 pubmed
    ..These results suggest that complement receptors maintain antibody responses by delivery of differentiation and survival signals to precursors of bone marrow plasma cells...
  50. Chetverin A, Kopein D, Chetverina H, Demidenko A, Ugarov V. Viral RNA-directed RNA polymerases use diverse mechanisms to promote recombination between RNA molecules. J Biol Chem. 2005;280:8748-55 pubmed
    ..The data favor an RNA transesterification reaction catalyzed by a conformation acquired by Qbeta replicase during RNA synthesis and provide a likely explanation for the very low frequency of homologous recombination in Qbeta phage...
  51. Chen Z, Boyd S, Calvo J, Murray K, Mejia G, Benjamin C, et al. Fluorescent Functionalization across Quaternary Structure in a Virus-like Particle. Bioconjug Chem. 2017;28:2277-2283 pubmed publisher
  52. Cui Z, Gorzelnik K, Chang J, Langlais C, Jakana J, Young R, et al. Structures of Q? virions, virus-like particles, and the Q?-MurA complex reveal internal coat proteins and the mechanism of host lysis. Proc Natl Acad Sci U S A. 2017;114:11697-11702 pubmed publisher
    ..For the canonical Allolevivirus Q? the maturation protein, A2, has an additional role as the lysis protein, by its ability to ..
  53. Udit A, Hollingsworth W, Choi K. Metal- and metallocycle-binding sites engineered into polyvalent virus-like scaffolds. Bioconjug Chem. 2010;21:399-404 pubmed publisher
    ..The versatility of the particles is further underscored by their multivalent nature, permitting simultaneously a range of activities for applications demanding polyfunctionality...
  54. Inokuchi Y, Kajitani M, Hirashima A. A study on the function of the glycine residue in the YGDD motif of the RNA-dependent RNA polymerase beta-subunit from RNA coliphage Q beta 1. J Biochem. 1994;116:1275-80 pubmed
    ..These results suggest that the Gly residue in this motif of Q beta replicase is involved in Mg(2+)-catalyzed polymerization. In the Mn(2+)-catalyzed polymerization, A357 and S357 replicases can act as well as the wild-type replicase...
  55. Kaminski P, Desnoues N, Elmerich C. The expression of nifA in Azorhizobium caulinodans requires a gene product homologous to Escherichia coli HF-I, an RNA-binding protein involved in the replication of phage Q beta RNA. Proc Natl Acad Sci U S A. 1994;91:4663-7 pubmed
    ..A null mutant, constructed by disruption of nrfA, exhibited the same phenotype as the missense mutant. Thus, an additional factor can be added to the already complex system of nifA regulation in A. caulinodans...
  56. Muffler A, Fischer D, Hengge Aronis R. The RNA-binding protein HF-I, known as a host factor for phage Qbeta RNA replication, is essential for rpoS translation in Escherichia coli. Genes Dev. 1996;10:1143-51 pubmed
    ..HF-I is the first factor known to be specifically involved in rpoS translation, and this role is the first cellular function to be identified for this abundant ribosome-associated RNA-binding protein in E. coli...
  57. Klovins J, Berzins V, van Duin J. A long-range interaction in Qbeta RNA that bridges the thousand nucleotides between the M-site and the 3' end is required for replication. RNA. 1998;4:948-57 pubmed
    ..We propose that, when replicase is bound to the internal recognition site, the 3' terminus of the template is juxtaposed to the enzyme's active site...
  58. Schuppli D, Miranda G, Qiu S, Weber H. A branched stem-loop structure in the M-site of bacteriophage Qbeta RNA is important for template recognition by Qbeta replicase holoenzyme. J Mol Biol. 1998;283:585-93 pubmed
    ..We therefore believe that the M-site interaction explains most of the role of S1 protein in the replication of Qbeta RNA by replicase...
  59. Schuster P. Polynucleotide evolution, hypercycles and the origin of the genetic code. Adv Space Res. 1984;4:143-51 pubmed
    ..Experiments on polynucleotide replication are described within the frame of a kinetic theory of molecular evolution. Four principles of early evolution are discussed and illustrated by means of a model for the origin of translation...
  60. Astronomo R, Kaltgrad E, Udit A, Wang S, Doores K, Huang C, et al. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds. Chem Biol. 2010;17:357-70 pubmed publisher
    ..The results presented reveal important design considerations for a carbohydrate-based vaccine component for HIV...
  61. Davis B. On producing more complexity than entropy in replication. Proc Natl Acad Sci U S A. 1994;91:6639-43 pubmed
    ..Some implications of kinetic irreversibility are considered in relation to the second law of thermodynamics and to the processing and translation of mRNA...
  62. Kajitani M, Kato A, Wada A, Inokuchi Y, Ishihama A. Regulation of the Escherichia coli hfq gene encoding the host factor for phage Q beta. J Bacteriol. 1994;176:531-4 pubmed
    ..The intracellular level of HF-I is about 30,000 to 60,000 molecules per cell, the majority being associated with ribosomes as one of the salt wash proteins. Taken together, we suggest that HF-I is one of the growth-related proteins...
  63. Miranda G, Schuppli D, Barrera I, Hausherr C, Sogo J, Weber H. Recognition of bacteriophage Qbeta plus strand RNA as a template by Qbeta replicase: role of RNA interactions mediated by ribosomal proteins S1 and host factor. J Mol Biol. 1997;267:1089-103 pubmed
    ..Qbeta RNA molecules with 3'-truncations formed 3'-terminal loops with similar efficiency as wild-type RNA, indicating that recognition of the 3'-end by host factor is not dependent on a specific 3'-terminal base sequence...
  64. Vasiljeva I, Kozlovska T, Cielens I, Strelnikova A, Kazaks A, Ose V, et al. Mosaic Qbeta coats as a new presentation model. FEBS Lett. 1998;431:7-11 pubmed
    ..A model insertion, short preS1 epitope 31-DPAFR-35 of hepatitis B surface antigen, demonstrated superficial location on the mosaic Qbeta particles and ensured specific antigenicity and immunogenicity...
  65. Takeshita D, Yamashita S, Tomita K. Mechanism for template-independent terminal adenylation activity of Q? replicase. Structure. 2012;20:1661-9 pubmed publisher
    ..Thus, the template for the template-independent 3'-adenylation by Q? replicase is the RNA and protein ribonucleoprotein complex...
  66. Mathu S, Knudsen C, van Duin J, Kraal B. Isolation of Qbeta polymerase complexes containing mutant species of elongation factor Tu. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;786:279-86 pubmed
    ..Thus, we were able to show a direct link between the vital tRNA binding property of EF-Tu and polymerase activity...
  67. Bacher J, Bull J, Ellington A. Evolution of phage with chemically ambiguous proteomes. BMC Evol Biol. 2003;3:24 pubmed
    ..The evolution of a small bacteriophage proteome to accommodate an unnatural amino acid analogue can provide insights into the number and type of substitutions that individual proteins will require to retain functionality...
  68. Nishihara T, Fujisaki S, Nishimura Y, Minami Y, Yubisui T. Analysis of six new genes encoding lysis proteins and coat proteins in Escherichia coli group A RNA phages. Microbiol Immunol. 2006;50:61-6 pubmed
    ..The phylogenetic analysis shows that the sub-groups A-I and A-II of E. coli RNA phages were clearly dispersed into two clusters...
  69. Blatchley E, Shen C, Scheible O, Robinson J, Ragheb K, Bergstrom D, et al. Validation of large-scale, monochromatic UV disinfection systems for drinking water using dyed microspheres. Water Res. 2008;42:677-88 pubmed
  70. Brown S, Fiedler J, Finn M. Assembly of hybrid bacteriophage Qbeta virus-like particles. Biochemistry. 2009;48:11155-7 pubmed publisher
    ..These results illustrate that cellular conditions should be taken into account even in apparently simple systems when natural or engineered protein nanoparticles are made...
  71. Rhee J, Baksh M, Nycholat C, Paulson J, Kitagishi H, Finn M. Glycan-targeted virus-like nanoparticles for photodynamic therapy. Biomacromolecules. 2012;13:2333-8 pubmed publisher
    ..This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet oxygen-generating payload...
  72. Ishiguro H, Nakano R, Yao Y, Kajioka J, Fujishima A, Sunada K, et al. Photocatalytic inactivation of bacteriophages by TiO2-coated glass plates under low-intensity, long-wavelength UV irradiation. Photochem Photobiol Sci. 2011;10:1825-9 pubmed publisher
    ..Furthermore, we showed that the ISO methodology for standard testing of antibacterial activity by TiO(2) photocatalysis can be applied to assess antiviral activity...
  73. Rumnieks J, Tars K. Crystal structure of the read-through domain from bacteriophage Q? A1 protein. Protein Sci. 2011;20:1707-12 pubmed publisher
    ..The N-terminal part of the read-through domain contains a prominent polyproline type II helix. The overall fold of the domain is not similar to any published structure in the Protein Data Bank...
  74. Arribas M, Cabanillas L, Lázaro E. Identification of mutations conferring 5-azacytidine resistance in bacteriophage Q?. Virology. 2011;417:343-52 pubmed publisher
  75. Simonet J, Gantzer C. Inactivation of poliovirus 1 and F-specific RNA phages and degradation of their genomes by UV irradiation at 254 nanometers. Appl Environ Microbiol. 2006;72:7671-7 pubmed
    ..Finally, extrapolation of inactivation and UV-induced RNA degradation kinetics highlights that genome degradation could fully explain UV-induced viral inactivation...
  76. Spohn G, Guler R, Johansen P, Keller I, Jacobs M, Beck M, et al. A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis. J Immunol. 2007;178:7450-7 pubmed
  77. Gale A, Elias D, Averell P, Teirstein P, Buck M, Brown S, et al. Engineered virus-like nanoparticles reverse heparin anticoagulation more consistently than protamine in plasma from heparin-treated patients. Thromb Res. 2011;128:e9-13 pubmed publisher
    ..These results provide the first step towards validation of heparin antagonist VLPs as viable alternatives to protamine...
  78. Udit A, Brown S, Baksh M, Finn M. Immobilization of bacteriophage Qbeta on metal-derivatized surfaces via polyvalent display of hexahistidine tags. J Inorg Biochem. 2008;102:2142-6 pubmed publisher
    ..These results illustrate the potential of metal-NTA surfaces for the self-assembled presentation of multi-functionalized particles to interrogate systems ranging from small molecule binding to whole cell interactions...