bacteriophage m13

Summary

Summary: Temperate bacteriophage of the genus INOVIRUS which infects enterobacteria, especially E. coli. It is a filamentous phage consisting of single-stranded DNA and is circularly permuted.

Top Publications

  1. Molenaar T, Michon I, de Haas S, Van Berkel T, Kuiper J, Biessen E. Uptake and processing of modified bacteriophage M13 in mice: implications for phage display. Virology. 2002;293:182-91 pubmed
    Internalization and degradation of filamentous bacteriophage M13 by a specific target cell may have major consequences for the recovery of phage in in vivo biopanning of phage libraries...
  2. Karlsson F, Malmborg Hager A, Albrekt A, Borrebaeck C. Genome-wide comparison of phage M13-infected vs. uninfected Escherichia coli. Can J Microbiol. 2005;51:29-35 pubmed
    ..Thus, global transcriptional analysis and functional analysis revealed previously unknown host responses to filamentous phage infection...
  3. Imai S, Mukai Y, Takeda T, Abe Y, Nagano K, Kamada H, et al. Effect of protein properties on display efficiency using the M13 phage display system. Pharmazie. 2008;63:760-4 pubmed
    ..These results indicate the usefulness in predicting a desired protein's compatibility with protein and peptide engineering using the phage display system...
  4. Lee Y, Yi H, Kim W, Kang K, Yun D, Strano M, et al. Fabricating genetically engineered high-power lithium-ion batteries using multiple virus genes. Science. 2009;324:1051-5 pubmed publisher
    ..This environmentally benign low-temperature biological scaffold could facilitate fabrication of electrodes from materials previously excluded because of extremely low electronic conductivity...
  5. Khalil A, Ferrer J, Brau R, Kottmann S, Noren C, Lang M, et al. Single M13 bacteriophage tethering and stretching. Proc Natl Acad Sci U S A. 2007;104:4892-7 pubmed
  6. Tsen K, Dykeman E, Sankey O, Lin N, Tsen S, Kiang J. Observation of the low frequency vibrational modes of bacteriophage M13 in water by Raman spectroscopy. Virol J. 2006;3:79 pubmed
    ..For example, rod-shaped viruses such as the M13 phage and tobacco mosaic virus have been successfully used as biological templates for the synthesis of semiconductor and metallic nanowires...
  7. Deng L, Perham R. Delineating the site of interaction on the pIII protein of filamentous bacteriophage fd with the F-pilus of Escherichia coli. J Mol Biol. 2002;319:603-14 pubmed
    ..These residues were found to cluster on the outer rim of the 3D structure of the D2 domain, unexpectedly identifying this as the F-pilus binding region on the pIII protein...
  8. Xu H, Cao B, George A, Mao C. Self-assembly and mineralization of genetically modifiable biological nanofibers driven by ?-structure formation. Biomacromolecules. 2011;12:2193-9 pubmed publisher
  9. Sitohy M, Chobert J, Karwowska U, Gozdzicka Jozefiak A, Haertle T. Inhibition of bacteriophage m13 replication with esterified milk proteins. J Agric Food Chem. 2006;54:3800-6 pubmed
    ..calf thymus histone and hen egg white lysozyme) were tested for their antiviral activity against the bacteriophage M13 and for their influence on its replication (except BCN)...

More Information

Publications73

  1. Houbiers M, Hemminga M. Protein-lipid interactions of bacteriophage M13 gene 9 minor coat protein. Mol Membr Biol. 2004;21:351-9 pubmed
    Gene 9 protein is one of the minor coat proteins of bacteriophage M13. The protein plays a role in the assembly process by associating with the host membrane by protein-lipid interactions...
  2. Hust M, Dubel S. Phage display vectors for the in vitro generation of human antibody fragments. Methods Mol Biol. 2005;295:71-96 pubmed
    ..Antibodies are expressed as scFV and Fab antibody fragments using various vector systems. This review offers a comprehensive overview of M13 phage display antibody vectors and discusses their applications...
  3. Mao C, Solis D, Reiss B, Kottmann S, Sweeney R, Hayhurst A, et al. Virus-based toolkit for the directed synthesis of magnetic and semiconducting nanowires. Science. 2004;303:213-7 pubmed
    ..Therefore, this system provides a genetic toolkit for growing and organizing nanowires from semiconducting and magnetic materials...
  4. Løset G, Bogen B, Sandlie I. Expanding the versatility of phage display I: efficient display of peptide-tags on protein VII of the filamentous phage. PLoS ONE. 2011;6:e14702 pubmed publisher
    ..Display on other coat proteins such as pVII allows for display of heterologous peptide sequences on the virions in addition to those displayed on pIII and pVIII. In addition, pVII display is an alternative to pIII or pVIII display...
  5. Dong D, Sutaria S, Hwangbo J, Chen P. A simple and rapid method to isolate purer M13 phage by isoelectric precipitation. Appl Microbiol Biotechnol. 2013;97:8023-9 pubmed publisher
    ..The yield curve is proportional to the growth curve of E. coli. On a 200-mL culture scale, 0.2 g L(-1) M13 phage (dry-weight) was produced by the isoelectric precipitation method. ..
  6. Nam Y, Magyar A, Lee D, Kim J, Yun D, Park H, et al. Biologically templated photocatalytic nanostructures for sustained light-driven water oxidation. Nat Nanotechnol. 2010;5:340-4 pubmed publisher
    ..Our results suggest that the biotemplated nanoscale assembly of functional components is a promising route to significantly improved photocatalytic water-splitting systems...
  7. Krumpe L, Atkinson A, Smythers G, Kandel A, Schumacher K, McMahon J, et al. T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries. Proteomics. 2006;6:4210-22 pubmed
    ..To demonstrate their utility, several of the T7-displayed peptide libraries were screened for streptavidin- and neutravidin-binding phage. Novel binding motifs were identified for each protein...
  8. Sum S, Wong D, Yuen M, Yuan H, Yu J, Lai C, et al. Real-time PCR assay using molecular beacon for quantitation of hepatitis B virus DNA. J Clin Microbiol. 2004;42:3438-40 pubmed
  9. Hagens S, Blasi U. Genetically modified filamentous phage as bactericidal agents: a pilot study. Lett Appl Microbiol. 2003;37:318-23 pubmed
    ..To evaluate the ability of a filamentous phage encoding lethal proteins to kill bacteria without host-cell lysis...
  10. Chung W, Oh J, Kwak K, Lee B, Meyer J, Wang E, et al. Biomimetic self-templating supramolecular structures. Nature. 2011;478:364-8 pubmed publisher
    ..Our assembly approach provides insight into the complexities of hierarchical assembly in nature and could be expanded to other chiral molecules to engineer sophisticated functional helical-twisted structures...
  11. Fosså A, Alsøe L, Crameri R, Funderud S, Gaudernack G, Smeland E. Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display. Cancer Immunol Immunother. 2004;53:431-8 pubmed
    ..Furthermore, candidate TAAs for vaccine development of PC were identified...
  12. Szardenings M. Phage display of random peptide libraries: applications, limits, and potential. J Recept Signal Transduct Res. 2003;23:307-49 pubmed
    ..This review summarizes the current state and the technical progress of the application of random peptide libraries using filamentous phage for ligand identification...
  13. Kügler J, Nieswandt S, Gerlach G, Meens J, Schirrmann T, Hust M. Identification of immunogenic polypeptides from a Mycoplasma hyopneumoniae genome library by phage display. Appl Microbiol Biotechnol. 2008;80:447-58 pubmed publisher
  14. Tsen K, Dykeman E, Sankey O, Tsen S, Lin N, Kiang J. Probing the low-frequency vibrational modes of viruses with Raman scattering--bacteriophage M13 in water. J Biomed Opt. 2007;12:024009 pubmed
    ..It is expected that the detection and characterization of this low-frequency vibrational mode can be used for applications in biomedical nanotechnology such as for monitoring the process of virus functionalization and self-assembly...
  15. Monjezi R, Tey B, Sieo C, Tan W. Purification of bacteriophage M13 by anion exchange chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:1855-9 pubmed publisher
    ..SDS-PAGE revealed that the purity of particles was comparable to that of CsCl gradient density ultracentrifugation method. Plaque forming assay showed that the purified phages were still infectious...
  16. Zhu H, Cao B, Zhen Z, Laxmi A, Li D, Liu S, et al. Controlled growth and differentiation of MSCs on grooved films assembled from monodisperse biological nanofibers with genetically tunable surface chemistries. Biomaterials. 2011;32:4744-52 pubmed publisher
    ..This work will advance our understanding on the interaction between stem cells and proteins...
  17. Hust M, Meysing M, Schirrmann T, Selke M, Meens J, Gerlach G, et al. Enrichment of open reading frames presented on bacteriophage M13 using hyperphage. Biotechniques. 2006;41:335-42 pubmed
    ..Together these data show that the Hyperphage-based enrichment system significantly improves the enrichment of ORFs and directly allows the display of the corresponding polypeptide on bacteriophage M13.
  18. Kwaśnikowski P, Kristensen P, Markiewicz W. Multivalent display system on filamentous bacteriophage pVII minor coat protein. J Immunol Methods. 2005;307:135-43 pubmed
    ..Our results demonstrate that the small size of pVII (33 amino acids) is not structurally compromised by fusion of scFv antibody fragments at their N-terminus, thus demonstrating the feasibility of utilizing pVII as a fusion partner...
  19. Marvin D, Welsh L, Symmons M, Scott W, Straus S. Molecular structure of fd (f1, M13) filamentous bacteriophage refined with respect to X-ray fibre diffraction and solid-state NMR data supports specific models of phage assembly at the bacterial membrane. J Mol Biol. 2006;355:294-309 pubmed
    ..Here we show that reinterpreted NMR data are also consistent with the model derived from X-ray fibre diffraction studies, and discuss models of virion assembly...
  20. Mi Z, Lu X, Mai J, Ng B, Wang G, Lechman E, et al. Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol Ther. 2003;8:295-305 pubmed
    ..Moreover, the results demonstrate the feasibility of identifying tissue-specific transduction peptides capable of mediating efficient transduction in vivo...
  21. Tornetta M, Reddy R, Wheeler J. Selection and maturation of antibodies by phage display through fusion to pIX. Methods. 2012;58:34-9 pubmed publisher
    ..A receptor extracellular domain and chemokine were subjected to this method of binning and affinity maturation. Parental clones demonstrated improvement in affinity from 1-100nM to 10-500pM...
  22. Rodi D, Soares A, Makowski L. Quantitative assessment of peptide sequence diversity in M13 combinatorial peptide phage display libraries. J Mol Biol. 2002;322:1039-52 pubmed
  23. Li K, Chen Y, Li S, Nguyen H, Niu Z, You S, et al. Chemical modification of M13 bacteriophage and its application in cancer cell imaging. Bioconjug Chem. 2010;21:1369-77 pubmed publisher
    ..Such dual-modified M13 particles showed very good binding affinity to human KB cancer cells, which demonstrated the potential applications of M13 bacteriophage in bioimaging and drug delivery...
  24. Nam K, Kim D, Yoo P, Chiang C, Meethong N, Hammond P, et al. Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes. Science. 2006;312:885-8 pubmed
  25. Chasteen L, Ayriss J, Pavlik P, Bradbury A. Eliminating helper phage from phage display. Nucleic Acids Res. 2006;34:e145 pubmed
  26. Gonzalez E, Robles Y, Govezensky T, Bobes R, Gevorkian G, Manoutcharian K. Isolation of neurocysticercosis-related antigens from a genomic phage display library of Taenia solium. J Biomol Screen. 2010;15:1268-73 pubmed publisher
    ..The described antigen discovery strategy may be used for the direct identification of antigens useful for host-pathogen interaction studies as well as for the development of molecular vaccines and diagnostics...
  27. Thomas C, Sharma S, Kumar G, Visweswariah S, Surolia A. Biopanning of endotoxin-specific phage displayed peptides. Biochem Biophys Res Commun. 2003;307:133-8 pubmed
    ..At a structural level, asymmetric distribution of the charged polar residues on one face of the helix and non-polar residues on the opposite face appears to correlate with their activity...
  28. Estephan E, Larroque C, Bec N, Martineau P, Cuisinier F, Cloitre T, et al. Selection and mass spectrometry characterization of peptides targeting semiconductor surfaces. Biotechnol Bioeng. 2009;104:1121-31 pubmed publisher
    ..We demonstrate that with increasing the dielectric constants of the employed solvents, adhesion of the SVSVGMKPSPRP peptide onto GaN(0001) is hindered...
  29. Stopar D, Spruijt R, Wolfs C, Hemminga M. Protein-lipid interactions of bacteriophage M13 major coat protein. Biochim Biophys Acta. 2003;1611:5-15 pubmed
    During the past years, remarkable progress has been made in our understanding of the replication cycle of bacteriophage M13 and the molecular details that enable phage proteins to navigate in the complex environment of the host cell...
  30. Nuraje N, Dang X, Qi J, Allen M, Lei Y, Belcher A. Biotemplated synthesis of perovskite nanomaterials for solar energy conversion. Adv Mater. 2012;24:2885-9 pubmed publisher
    ..Genetically engineered viruses provide effective templates for perovskite nanomaterials. The virus-templated nanocrystals are small in size, highly crystalline, and show photocatalytic and photovoltaic properties...
  31. Lee S, Mao C, Flynn C, Belcher A. Ordering of quantum dots using genetically engineered viruses. Science. 2002;296:892-5 pubmed
    ..In addition, suspensions were prepared in which the lyotropic liquid crystalline phase behavior of the hybrid material was controlled by solvent concentration and by the use of a magnetic field...
  32. Scholle M, Kriplani U, Pabon A, Sishtla K, Glucksman M, Kay B. Mapping protease substrates by using a biotinylated phage substrate library. Chembiochem. 2006;7:834-8 pubmed
    We describe a bacteriophage M13 substrate library encoding the AviTag (BirA substrate) and combinatorial heptamer peptides displayed at the N terminus of the mature form of capsid protein III...
  33. Nagler C, Nagler G, Kuhn A. Cysteine residues in the transmembrane regions of M13 procoat protein suggest that oligomeric coat proteins assemble onto phage progeny. J Bacteriol. 2007;189:2897-905 pubmed
    ..This inhibition of the leader peptidase results in death of the cell and shows that there are distinct amino acid residues in the M13 procoat protein involved at specific steps of the phage assembly process...
  34. Lin A, Jimenez J, Derr J, VERA P, Manapat M, Esvelt K, et al. Inhibition of bacterial conjugation by phage M13 and its protein g3p: quantitative analysis and model. PLoS ONE. 2011;6:e19991 pubmed publisher
  35. Sweeney R, Park E, Iverson B, Georgiou G. Assembly of multimeric phage nanostructures through leucine zipper interactions. Biotechnol Bioeng. 2006;95:539-45 pubmed
    ..This resulted in 3D assembly with three individual phages attached at a single point. These ordered phage structures should provide a foundation for self-assembly of virally templated nanomaterials into useful devices...
  36. Kehoe J, Kay B. Filamentous phage display in the new millennium. Chem Rev. 2005;105:4056-72 pubmed
  37. Sartorius R, Pisu P, D Apice L, Pizzella L, Romano C, Cortese G, et al. The use of filamentous bacteriophage fd to deliver MAGE-A10 or MAGE-A3 HLA-A2-restricted peptides and to induce strong antitumor CTL responses. J Immunol. 2008;180:3719-28 pubmed
  38. Spruijt R, Meijer A, Wolfs C, Hemminga M. Localization and rearrangement modulation of the N-terminal arm of the membrane-bound major coat protein of bacteriophage M13. Biochim Biophys Acta. 2000;1509:311-23 pubmed
    During infection the major coat protein of the filamentous bacteriophage M13 is in the cytoplasmic membrane of the host Escherichia coli...
  39. Rodi D, Makowski L. Phage-display technology--finding a needle in a vast molecular haystack. Curr Opin Biotechnol. 1999;10:87-93 pubmed
    ..Over the past year, it has been used to solve an increasing diversity of problems, including identification of binding motifs for much smaller targets and the use of novel screening methods to identify chemical activities...
  40. Sidhu S. Engineering M13 for phage display. Biomol Eng. 2001;18:57-63 pubmed
    ..These improvements expand the utility of phage display as a powerful tool in modern biotechnology...
  41. Stopar D, Spruijt R, Wolfs C, Hemminga M. Structural characterization of bacteriophage M13 solubilization by amphiphiles. Biochim Biophys Acta. 2002;1594:54-63 pubmed
    The structural properties of bacteriophage M13 during disassembly were studied in different membrane model systems, composed of a homologue series of the detergents sodium octyl sulfate, sodium decyl sulfate, and sodium dodecyl sulfate...
  42. Baek H, Suk K, Kim Y, Cha S. An improved helper phage system for efficient isolation of specific antibody molecules in phage display. Nucleic Acids Res. 2002;30:e18 pubmed
  43. Hussein A, Davis E, Halperin S, Lee S. Construction and characterization of single-chain variable fragment antibodies directed against the Bordetella pertussis surface adhesins filamentous hemagglutinin and pertactin. Infect Immun. 2007;75:5476-82 pubmed
    ..BALB/c mice who received recombinant phage-treated B. pertussis had reduced bacterial counts in the nasal cavity, trachea, and lungs compared to the control groups. ..
  44. Antonara S, Chafel R, Lafrance M, Coburn J. Borrelia burgdorferi adhesins identified using in vivo phage display. Mol Microbiol. 2007;66:262-76 pubmed
    ..The use of in vivo phage display is one approach to the identification of adhesins in pathogenic bacteria that are not easily grown in the laboratory, or for which genetic manipulations are not straightforward. ..
  45. Knurr J, Benedek O, Heslop J, Vinson R, Boydston J, McAndrew J, et al. Peptide ligands that bind selectively to spores of Bacillus subtilis and closely related species. Appl Environ Microbiol. 2003;69:6841-7 pubmed
    ..Finally, we discuss the use of peptide ligands for bacterial detection and the use of short peptide sequences for targeting proteins during spore formation. ..
  46. Johnson J, Nettikadan S, Vengasandra S, Henderson E. Analysis of solid-phase immobilized antibodies by atomic force microscopy. J Biochem Biophys Methods. 2004;59:167-80 pubmed
    ..As the number and complexity of chip-based analytical platforms in proteomics increases, rapid selection/screening processes such as that described here will become invaluable. ..
  47. Rossetti L, Giraffa G. Rapid identification of dairy lactic acid bacteria by M13-generated, RAPD-PCR fingerprint databases. J Microbiol Methods. 2005;63:135-44 pubmed
    ..The same approach could also be applied to identify LAB strains isolated from other food ecosystems. ..
  48. Thapa N, Kim S, So I, Lee B, Kwon I, Choi K, et al. Discovery of a phosphatidylserine-recognizing peptide and its utility in molecular imaging of tumour apoptosis. J Cell Mol Med. 2008;12:1649-60 pubmed publisher
    ..This application would clearly be relevant to assessments of the efficacy of anticancer therapy in tumours. ..
  49. García Villada L, Drake J. Mutational clusters generated by non-processive polymerases: A case study using DNA polymerase betain vitro. DNA Repair (Amst). 2010;9:871-8 pubmed publisher
  50. Krishnan R, Tsubery H, Proschitsky M, Asp E, Lulu M, Gilead S, et al. A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies. J Mol Biol. 2014;426:2500-19 pubmed publisher
    ..Taken together, our studies show that g3p(N1N2) acts as a general amyloid interaction motif. ..
  51. Nam K, Wartena R, Yoo P, Liau F, Lee Y, Chiang Y, et al. Stamped microbattery electrodes based on self-assembled M13 viruses. Proc Natl Acad Sci U S A. 2008;105:17227-31 pubmed publisher
    ..This versatile approach for fabricating and positioning electrodes may provide greater flexibility for implementing advanced battery designs such as those with interdigitated microelectrodes or 3D architectures. ..
  52. Holmqvist P, Ratajczyk M, Meier G, Wensink H, Lettinga M. Supersaturated dispersions of rodlike viruses with added attraction. Phys Rev E Stat Nonlin Soft Matter Phys. 2009;80:031402 pubmed
    ..Surprisingly, the experiments showed that also the absolute induction time, the critical nucleus, and the growth rate are insensitive of the attraction if the concentration is scaled to the distance to the phase boundaries. ..
  53. Blanch E, Hecht L, Syme C, Volpetti V, Lomonossoff G, Nielsen K, et al. Molecular structures of viruses from Raman optical activity. J Gen Virol. 2002;83:2593-600 pubmed
    ..This information is not available from the X-ray crystal structure of cowpea mosaic virus since no nucleic acid is visible...
  54. Park H, Kim J, Cho J, Moon J, Lee S, Yoon M. Phage display screen for peptides that bind Bcl-2 protein. J Biomol Screen. 2011;16:82-9 pubmed publisher
    ..These peptides can be used to develop novel diagnostic probes or potent inhibitors with diverse polyvalencies...
  55. Danilova I, Shevelev I, Isaev Ivanov V, Noskin L. [Molecular reasons for the regulation of the enzymatic activity of bovine pancreatic deoxyribonuclease I as studied by dynamic light scattering and fluorescent spectroscopy]. Biofizika. 2005;50:49-61 pubmed
    ..The results provide evidence that conformational changes of the protein molecule in all cases are more substantial that it could be expected from X-ray data published earlier...
  56. Kalarical Janardhanan S, Narayan S, Abbineni G, Hayhurst A, Mao C. Architectonics of phage-liposome nanowebs as optimized photosensitizer vehicles for photodynamic cancer therapy. Mol Cancer Ther. 2010;9:2524-35 pubmed publisher
    ..This study highlights the ability of phage-liposome nanowebs to serve as efficient carriers in the transport of photosensitizers to cancer cells...
  57. Tombolato F, Ferrarini A, Grelet E. Chiral nematic phase of suspensions of rodlike viruses: left-handed phase helicity from a right-handed molecular helix. Phys Rev Lett. 2006;96:258302 pubmed
    ..This hypothesis is supported by calculations based on a coarse-grained representation of the virus...
  58. Kappen L, Xi Z, Jones G, Goldberg I. Stimulation of DNA strand slippage synthesis by a bulge binding synthetic agent. Biochemistry. 2003;42:2166-73 pubmed
  59. Gaitanis G, Velegraki A, Alexopoulos E, Kapsanaki Gotsi E, Zisova L, Ran Y, et al. Malassezia furfur fingerprints as possible markers for human phylogeography. ISME J. 2009;3:498-502 pubmed publisher
    ..These initial data address the hypothesis that M. furfur could be a eukaryotic candidate eligible for phylogeographic studies...
  60. Kuzmicheva G, Jayanna P, Sorokulova I, Petrenko V. Diversity and censoring of landscape phage libraries. Protein Eng Des Sel. 2009;22:9-18 pubmed publisher
  61. Matamoros T, Kim B, Menendez Arias L. Mechanistic insights into the role of Val75 of HIV-1 reverse transcriptase in misinsertion and mispair extension fidelity of DNA synthesis. J Mol Biol. 2008;375:1234-48 pubmed
    ..Altogether, these data suggest that Val75 interactions with the 5' template overhang are important determinants of fidelity...
  62. Ahmed N, Dhanapala P, Sadli N, Barrow C, Suphioglu C. Mimtags: the use of phage display technology to produce novel protein-specific probes. J Immunol Methods. 2014;405:121-9 pubmed publisher
  63. Vijayakumar P, Prasad B. Intracellular biogenic silver nanoparticles for the generation of carbon supported antiviral and sustained bactericidal agents. Langmuir. 2009;25:11741-7 pubmed publisher
    ..The bactericidal effects were noticed even after washing and repeated exposure of these carbon supported silver nanoparticles to fresh bacterial cultures, revealing their sustained activity...
  64. Jakob R, Schmid F. Molecular determinants of a native-state prolyl isomerization. J Mol Biol. 2009;387:1017-31 pubmed publisher
    ..Such interrelations between local folding and prolyl isomerization and the potential modulation by prolyl isomerases might also be used to break and reestablish slow communication pathways in proteins...